Uma síndrome mielodisplásica caracterizada pela presença de 5-19% de mieloblastos na medula óssea ou 2-19% de blastos no sangue periférico. Ela se divide em duas categorias: síndrome mielodisplásica com excesso de blastos-1 e síndrome mielodisplásica com excesso de blastos-2.
Introdução
O que você precisa saber de cara
Uma síndrome mielodisplásica caracterizada pela presença de 5-19% de mieloblastos na medula óssea ou 2-19% de blastos no sangue periférico. Ela se divide em duas categorias: síndrome mielodisplásica com excesso de blastos-1 e síndrome mielodisplásica com excesso de blastos-2.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 9 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 22 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
1 gene identificado com associação a esta condição. Padrão de herança: Not applicable.
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position
NucleusChromosome
Variantes genéticas (ClinVar)
233 variantes patogênicas registradas no ClinVar.
Vias biológicas (Reactome)
2 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Neoplasia mielodisplásica com excesso de blastos
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The mature plasmacytoid dendritic cell proliferation associated with myeloid neoplasm represents a clonal proliferation of plasmacytoid dendritic cells within myeloproliferative and myelodysplastic disorders. This entity was recently recognized as a distinct condition in the fifth edition of the World Health Organization classification of hematolymphoid tumors. It occurs in approximately 4.9% of acute myeloid leukemia cases. The pathogenic mechanisms underlying this proliferation and the role of these cells in disease progression remain poorly understood. Nevertheless, the plasmacytoid dendritic cell proliferation associated with acute myeloid leukemia is related to distinct genetic abnormalities, worse prognosis, reduced overall survival, lower sensitivity to conventional acute myeloid leukemia therapies, and an increased risk of relapse. It also displays distinct immunophenotypic features compared to other types of mature plasmacytoid dendritic cell proliferation, raising questions about its classification and diagnostic criteria. This review provides a comprehensive overview of current knowledge regarding the plasmacytoid dendritic cell proliferation associated with acute myeloid leukemia, including terminology inconsistencies; the role of plasmacytoid dendritic cells in this entity; associated genetic alterations; immunophenotypic and morphological characteristics of blasts and plasmacytoid dendritic cells; clinical outcomes and prognostic impact; and therapeutic approaches and perspectives. Synthesizing current evidence may help improve disease recognition and highlight gaps in knowledge to guide future research.
Aberrant CD25 and Increased CD123 Expression Are Common in Acute Myeloid Leukemia with KMT2A Partial Tandem Duplication and Are Associated with FLT3 Internal Tandem Duplication.
KMT2A partial tandem duplication (PTD) occurs in approximately 5-10% of acute myeloid leukemia (AML) cases and is associated with poor prognosis. While its cytogenetic and molecular features are well described, the immunophenotypic characteristics of AML with KMT2A-PTD remain incompletely defined. We identified 47 cases of AML with KMT2A-PTD by optical genome mapping. All cases underwent flow cytometric immunophenotypic analysis and next-generation sequencing using an 81-gene panel. The cohort included 32 men and 15 women with a median age of 67 years (range, 19-87). Thirty-eight cases were de novo AML, and nine were secondary to myelodysplastic syndrome and/or myeloproliferative neoplasm. Most cases (93%) demonstrated a normal or non-complex karyotype. The most frequent mutations involved FLT3-ITD (47%), DNMT3A (43%), and RUNX1 (23%). Thirty-one cases (66%) were granulocytic, while 16 (34%) showed granulocytic and/or monocytic differentiation. Blasts uniformly expressed HLA-DR and frequently expressed CD117 (91%) and CD34 (79%). Increased expression of CD123 (74%) and CD117 (43%) and decreased expression of HLA-DR (74%) and CD38 (69%) were common. Aberrant CD25 expression was observed in 51% of cases. Increased CD123 and aberrant CD25 expression were significantly associated with FLT3-ITD mutations (both p < 0.0001) but not with other recurrent mutations. There was no correlation between FLT3-ITD mutation and expression levels of CD117, CD38 or HLA-DR (all p > 0.05). AML with KMT2A-PTD shows distinctive immunophenotypic features with increased CD123 and aberrant CD25 expression, both associated with FLT3-ITD. These markers may have diagnostic and therapeutic relevance in this AML subtype.
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Myelodysplastic syndromes (MDSs) are a group of highly heterogeneous myeloid clonal diseases. Anemia is the most common clinical symptom, yet its pathogenesis remains incompletely understood. Preliminary evidence suggests an increase in macrophage infiltration and iron load in the bone marrow of patients with an MDS, alongside elevated interleukin-6 (IL-6) expression in bone marrow mesenchymal stem cells (BMSCs). The Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) pathway is a critical regulator of cellular antioxidant responses and inflammation, but its role in mediating the effects of iron overload in the microenvironment of patients with an MDS remains unclear. This study aims to investigate the hypothesis that iron-overloaded bone marrow macrophages promote BMSC senescence and IL-6 secretion via the Keap1-Nrf2-ARE pathway, thereby impairing the survival and differentiation of hematopoietic stem cells and hematopoietic progenitor cells and contributing to anemia. Specific objectives are to (1) quantify the macrophage iron load across major MDS subtypes and correlate it with anemia severity and prognosis; (2) define the phenotype of erythroid island macrophages (CD68+, CD169+, and vascular cell adhesion molecule 1+) and the expression of endothelial microparticles in bone marrow tissues of patients with an MDS; and (3) experimentally test whether iron-overloaded macrophages and their exosomes regulate IL-6 secretion and senescence in BMSCs via the Keap1-Nrf2-ARE pathway. Bone marrow samples will be collected from patients with key MDS subtypes (MDS with single-lineage dysplasia, refractory anemia with ring sideroblasts, MDS with multilineage dysplasia, and MDS with excess blasts; n=30 per subgroup) and control patients with iron-deficiency anemia (n=30). Methods will include histochemistry (Perls Prussian blue staining), immunohistochemistry and immunofluorescence (for macrophage and endothelial microparticle analysis), enzyme-linked immunosorbent assay, flow cytometry, quantitative polymerase chain reaction, and Western blotting. An in vitro model of iron-overloaded macrophages will be established using phorbol 12-myristate 13-acetate-differentiated THP-1 cells treated with ferric ammonium citrate. Exosomes will be isolated from these macrophages via ultracentrifugation. The effects of iron-overloaded macrophages and their exosomes on BMSC IL-6 secretion, senescence (senescence-associated β-galactosidase staining), and Keap1-Nrf2-ARE pathway activity will be assessed in coculture systems, with and without pharmacological inhibitors (5,6-dichloro-1-β-D-ribofuranosylbenzimidazole) or activators (dimethyl fumarate) of Nrf2. The study received ethics approval in December 2024. Patient recruitment and sample collection are in progress. As of December 2025, a total of 85 samples had been accrued. Pilot experiments to optimize macrophage differentiation and iron loading conditions have been completed. The full experimental workflow, including all sample analyses and in vitro experiments, is anticipated to be completed by May 2026. This study is expected to elucidate a novel molecular mechanism linking iron overload in macrophages to BMSC dysfunction and anemia in MDS. The findings could identify the Keap1-Nrf2-ARE pathway as a potential therapeutic target for managing MDS-related anemia. DERR1-10.2196/77936.
Blood biomarkers are altered in elderly hematological patients exhibiting a mosaic loss of the Y chromosome in bone marrow cells.
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Publicações recentes
Clinical Outcomes in Patients With Refractory Anemia With Excess Blasts (RAEB) Who Receive Hypomethylating Agents (HMAs).
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Evaluation of in vitro rat and human airway epithelial models for acute inhalation toxicity testing.
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📚 EuropePMCmostrando 161
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CancersThe Role of Iron-Overloaded Macrophages in Mesenchymal Stem Cell Senescence and Anemia in Myelodysplastic Syndromes: Protocol for an In Vitro Study.
JMIR research protocolsBlood biomarkers are altered in elderly hematological patients exhibiting a mosaic loss of the Y chromosome in bone marrow cells.
BMC cancerEffect of peritransplant measurable residual disease clearance in patients with myelodysplastic neoplasm: a referral center experience.
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Pathology oncology research : PORA comparison of WHO-5 and ICC classifications in a series of myeloid neoplasms, considerations for hematopathologists and molecular pathologists.
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[Rinsho ketsueki] The Japanese journal of clinical hematologyOutcome of Myelodysplastic Syndromes Over Time in the United States: A National Cancer Data Base Study From 2004-2013.
Mayo Clinic proceedings[Outcomes and prognostic factors of myelodysplastic syndrome patients with allogeneic hematopoietic stem cell transplantation].
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Medicina clinicaHistone Deacetylase Inhibition with Panobinostat Combined with Intensive Induction Chemotherapy in Older Patients with Acute Myeloid Leukemia: Phase I Study Results.
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International journal of laboratory hematologyGATA2 mutation in long stand Mycobacterium kansasii infection, myelodysplasia and MonoMAC syndrome: a case-report.
BMC medical geneticsDecitabine improves overall survival in myelodysplastic syndromes-RAEB patients aged ≥60 years and has lower toxicities: Comparison with low-dose chemotherapy.
Blood cells, molecules & diseases[Comparation of Clinical Efficacy between Two Regimens of Preexcitation Chemotherapy for MDS-RAEB Patients].
Zhongguo shi yan xue ye xue za zhiAzacitidine maintenance after intensive chemotherapy improves DFS in older AML patients.
BloodDecitabine for myelodysplastic syndromes: dose comparison in a real world clinical setting.
Leukemia & lymphomaIncreased cardiovascular comorbidities in patients with myelodysplastic syndromes and chronic myelomonocytic leukemia presenting with systemic inflammatory and autoimmune manifestations.
Seminars in hematologyAssociations of complementation group, ALDH2 genotype, and clonal abnormalities with hematological outcome in Japanese patients with Fanconi anemia.
Annals of hematologyDyserythropoiesis evaluated by the RED score and hepcidin:ferritin ratio predicts response to erythropoietin in lower-risk myelodysplastic syndromes.
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The Malaysian journal of pathologyPutative new childhood leukemia cancer predisposition syndrome caused by germline bi-allelic missense mutations in DDX41.
Genes, chromosomes & cancerHematopoietic cell transplant for acute myeloid leukemia and myelodysplastic syndrome: conditioning regimen intensity.
Blood advancesAn uncommon t(9;11)(p24;q22) with monoallelic loss of ATM and KMT2A genes in a child with myelodysplastic syndrome/acute myeloid leukemia who evolved from Fanconi anemia.
Molecular cytogeneticsConstitutional mutations of the CHEK2 gene are a risk factor for MDS, but not for de novo AML.
Leukemia researchPentraxin-3 polymorphisms and invasive mold infections in acute leukemia patients receiving intensive chemotherapy.
HaematologicaA rare case of an acquired factor V inhibitor in a patient with myelodysplastic syndrome during azacitidine treatment.
Annals of hematologyMoleculary Confirmed, Cytogenetic Remission in a Case with Myelodysplastic Syndrome Treated with Azacitidne.
Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)How I treat myelodysplastic syndromes of childhood.
BloodAssociation of red cell distribution width with clinical outcomes in myelodysplastic syndrome.
Leukemia researchHarnessing the PD-1 Pathway in Myelodysplastic Syndrome.
American journal of therapeutics[Gene mutations from 511 myelodysplastic syndromes patients performed by targeted gene sequencing].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhiThe prognostic value of circulating myeloblasts in patients with myelodysplastic syndromes.
Annals of hematology[Clinical Efficacy of Low-dose Decitabine Combined with CAG Regimen in Patients with Myelodysplastic Syndrome-refractory Anemia with Excess Blasts(MDS-RAEB)].
Zhongguo shi yan xue ye xue za zhiTranscriptome analysis of CD34+ cells from myelodysplastic syndrome patients.
Leukemia research[The efficacy and safety of the patients of myelodysplastic syndromes-refractory anemia with excess blasts treated with decitabine alone or CAG/HAG regimen].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhiAlloimmune hemolysis due to major RhE incompatibility after unrelated cord blood transplantation.
Leukemia & lymphomaBiologics in myelodysplastic syndrome-related systemic inflammatory and autoimmune diseases: French multicenter retrospective study of 29 patients.
Autoimmunity reviewsTP53 and IDH2 Somatic Mutations Are Associated With Inferior Overall Survival After Allogeneic Hematopoietic Cell Transplantation for Myelodysplastic Syndrome.
Clinical lymphoma, myeloma & leukemiaSevere atypical herpes zoster as an initial symptom of fatal myelodysplastic syndrome with refractory anemia and blast excess (RAEB II).
Clinical, cosmetic and investigational dermatologyp53 protein expression in patients with myelodysplasia treated with allogeneic bone marrow transplantation.
Molecular and clinical oncologyA phase 1 study of the CXCR4 antagonist plerixafor in combination with high-dose cytarabine and etoposide in children with relapsed or refractory acute leukemias or myelodysplastic syndrome: A Pediatric Oncology Experimental Therapeutics Investigators' Consortium study (POE 10-03).
Pediatric blood & cancerCytogenetics and comorbidity predict outcomes in older myelodysplastic syndrome patients after allogeneic stem cell transplantation using reduced intensity conditioning.
CancerEnhanced plasma protein carbonylation in patients with myelodysplastic syndromes.
Free radical biology & medicineErythrophagocytosis by blasts in a case of de novo acute monoblastic leukemia with rare but characteristic t(8;16).
Journal of postgraduate medicineClinical, hematological, and cytogenetic profile of adult myelodysplastic syndrome in a tertiary care center.
Journal of blood medicineErythrocytosis after allogeneic hematopoietic stem cell transplantation.
Clinical transplantationDecitabine priming prior to low-dose chemotherapy improves patient outcomes in myelodysplastic syndromes-RAEB: a retrospective analysis vs. chemotherapy alone.
Journal of cancer research and clinical oncology[Large vessel vasculitis with myelodysplastic syndrome: A rare association].
La Revue de medecine interneAcquired elliptocytosis in the setting of a refractory anemia with excess blasts and del(20q).
BloodBone marrow morphology and disease progression in congenital thrombocytopenia: a detailed clinicopathologic and genetic study of eight cases.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, IncThe effects of azacitidine on the response and prognosis of myelodysplastic syndrome and acute myeloid leukemia involving a bone marrow erythroblast frequency of >50.
Leukemia researchMyelodysplastic and myeloproliferative disorders of childhood.
Hematology. American Society of Hematology. Education ProgramAllogeneic haematopoietic stem cell transplant in patients with lower risk myelodysplastic syndrome: a retrospective analysis on behalf of the Chronic Malignancy Working Party of the EBMT.
Bone marrow transplantationPseudo-Chédiak-Higashi granules and other unusual cytoplasmic inclusions in refractory anaemia with excess blasts-2.
British journal of haematology[Analysis of the impact of decitabine treatment cycles on efficacy and safety in patients of myelodysplastic syndrome-refractory anemia with excess blasts].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhiCharacteristics of the phenotypic abnormalities of bone marrow cells in childhood myelodysplastic syndromes and juvenile myelomonocytic leukemia.
Pediatric blood & cancerChanges in the Updated 2016: WHO Classification of the Myelodysplastic Syndromes and Related Myeloid Neoplasms.
Clinical lymphoma, myeloma & leukemiaGermline variants in ETV6 underlie reduced platelet formation, platelet dysfunction and increased levels of circulating CD34+ progenitors.
HaematologicaComparative clinical effectiveness of azacitidine versus decitabine in older patients with myelodysplastic syndromes.
British journal of haematologySuccessful Allogenic Haematopoietic Stem Cell Transplantation in a Boy with Hemophilia A and MDS-RAEB.
Klinische PadiatrieModest improvement in survival of patients with refractory anemia with excess blasts in the hypomethylating agents era in the United States.
Leukemia & lymphomaRuxolitinib in steroid refractory graft-vs.-host disease: a case report.
Journal of hematology & oncologyAcute erythroid leukemia with <20% bone marrow blasts is clinically and biologically similar to myelodysplastic syndrome with excess blasts.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, IncConsidering Bone Marrow Blasts From Nonerythroid Cellularity Improves the Prognostic Evaluation of Myelodysplastic Syndromes.
Journal of clinical oncology : official journal of the American Society of Clinical OncologyMyelodysplastic Syndrome with concomitant t(5;21)(q15;q22) and del(5)(q13q33): case report and review of literature.
Stem cell investigationMonitoring of the Clonal Fraction by Fluorescence In Situ Hybridization in Myelodysplastic Syndrome: Comparison With International Working Group Treatment Response Criteria.
Archives of pathology & laboratory medicinePatients With a History of Chemotherapy and Isolated del(20q) With Minimal Myelodysplasia Have an Indolent Course.
American journal of clinical pathologyAzacitidine versus decitabine in patients with refractory anemia with excess blast-Results of multicenter study.
Leukemia researchEffects of decitabine on megakaryocyte maturation in patients with myelodysplastic syndromes.
Oncology lettersPaclitaxel Induced MDS and AML: A Case Report and Literature Review.
Case reports in oncological medicineTreatment of pyoderma gangrenosum with thalidomide in a myelodysplastic syndrome case.
International medical case reports journalSecretion and Expression of Matrix Metalloproteinase-2 and 9 from Bone Marrow Mononuclear Cells in Myelodysplastic Syndrome and Acute Myeloid Leukemia.
Asian Pacific journal of cancer prevention : APJCPSpectrum of the WHO Classification De Novo Myelodysplastic Syndrome: Experience from Southern Pakistan.
Asian Pacific journal of cancer prevention : APJCPAn Unexpected Innocent Complication Associated with Azacitidine Treatment of Myelodysplastic Syndrome: Erythema Annulare Centrifugum.
Turkish journal of haematology : official journal of Turkish Society of HaematologyRole of microRNA-29b in myelodysplastic syndromes during transformation to overt leukaemia.
PathologyLoss of B cells and their precursors is the most constant feature of GATA-2 deficiency in childhood myelodysplastic syndrome.
HaematologicaMyelodysplastic Syndrome Revealed by Systems Immunology in a Melanoma Patient Undergoing Anti-PD-1 Therapy.
Cancer immunology researchPredictors of survival in refractory anemia with ring sideroblasts and thrombocytosis (RARS-T) and the role of next-generation sequencing.
American journal of hematologyEfficacy and safety of homoharringtonine plus cytarabine and aclarubicin for patients with myelodysplastic syndrome-RAEB.
Oncology lettersInfusion of CD3/CD28 costimulated umbilical cord blood T cells at the time of single umbilical cord blood transplantation may enhance engraftment.
American journal of hematologyLow Dose Cytosine Arabinoside and Azacitidine Combination in Elderly Patients with Acute Myeloid Leukemia and Refractory Anemia with Excess Blasts (MDS-RAEB2).
Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood TransfusionGenomic loss of EZH2 leads to epigenetic modifications and overexpression of the HOX gene clusters in myelodysplastic syndrome.
Oncotarget[Lenalidomide treatment in myelodysplastic syndrome with 5q deletion--Czech MDS group experience].
Vnitrni lekarstviInteractions and relevance of blast percentage and treatment strategy among younger and older patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS).
American journal of hematologyPrimary cutaneous smoldering adult T-cell leukemia/ lymphoma.
Dermatology online journalPrognostic impact of chromosomal translocations in myelodysplastic syndromes and chronic myelomonocytic leukemia patients. A study by the spanish group of myelodysplastic syndromes.
Genes, chromosomes & cancerMyeloid Sarcoma of the Bladder in the Setting of Refractory Anemia with Excess Blasts-2 (RAEB-2).
The West Virginia medical journal[Unidentified Inflammatory Disease Induced by Azacitidine Therapy for Myelodysplastic Syndrome].
Gan to kagaku ryoho. Cancer & chemotherapy[Clinical and cytogenetic study of chromosome 1 abnormality in myelodysplastic syndrome].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhiOllier's Disease with Myelodysplastic Syndrome.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSPPlasma Protein Biomarker Candidates for Myelodysplastic Syndrome Subgroups.
BioMed research internationalSalvaged single-unit cord blood transplantation for 26 patients with hematologic malignancies not in remission.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicasDecitabine versus best supportive care in older patients with refractory anemia with excess blasts in transformation (RAEBt) - results of a subgroup analysis of the randomized phase III study 06011 of the EORTC Leukemia Cooperative Group and German MDS Study Group (GMDSSG).
Annals of hematologyA Case of Refractory Anemia with Excess Blast-2 with Sole Trisomy 13.
Clinical laboratoryMyelodysplastic syndromes in Chernobyl clean-up workers.
Annals of hematologyIsolated trisomy 13 in refractory anemia with excess blasts: report of two cases and a brief literature review of this possible association.
Leukemia & lymphomaMarked Hematopoiesis Masquerading Multiple Bone Metastasis in a Lung Cancer Patient With Myelodysplastic Syndrome.
Clinical nuclear medicineSF3B1 mutation identifies a distinct subset of myelodysplastic syndrome with ring sideroblasts.
Blood[Analysis of the karyotype abnormalities and its prognostic in 298 patients with myelodysplastic syndrome].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhiSurvey of expert opinions and related recommendations regarding bridging therapy using hypomethylating agents followed by allogeneic transplantation for high-risk MDS.
Critical reviews in oncology/hematology[Treatment of myelodysplastic syndrome by hematopoietic stem cell transplantation combined with Chinese medical syndrome typing: a clinical study].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicineThe level of bone marrow WT1 message is a useful marker to differentiate myelodysplastic syndromes with low blast percentage from cytopenia due to other reasons.
Internal medicine (Tokyo, Japan)Refractory thrombocytopenia and neutropenia: a diagnostic challenge.
Mediterranean journal of hematology and infectious diseasesEffects of 5-azacytidine on natural killer cell activating receptor expression in patients with refractory anemia with excess of blasts.
Leukemia research reportsMulticentric study underlining the interest of adding CD5, CD7 and CD56 expression assessment to the flow cytometric Ogata score in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms.
HaematologicaA nationwide non-interventional epidemiological data registry on myelodysplastic syndromes in Lebanon.
American journal of blood researchAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- The emerging role of plasmacytoid dendritic cell proliferation in acute myeloid leukemia.
- Aberrant CD25 and Increased CD123 Expression Are Common in Acute Myeloid Leukemia with KMT2A Partial Tandem Duplication and Are Associated with FLT3 Internal Tandem Duplication.
- The Role of Iron-Overloaded Macrophages in Mesenchymal Stem Cell Senescence and Anemia in Myelodysplastic Syndromes: Protocol for an In Vitro Study.
- Blood biomarkers are altered in elderly hematological patients exhibiting a mosaic loss of the Y chromosome in bone marrow cells.
- Effect of peritransplant measurable residual disease clearance in patients with myelodysplastic neoplasm: a referral center experience.
- Clinical Outcomes in Patients With Refractory Anemia With Excess Blasts (RAEB) Who Receive Hypomethylating Agents (HMAs).
- Single-unit unrelated cord blood transplantation versus HLA-matched sibling transplantation in adults with advanced myelodysplastic syndrome: A registry-based study from the adult MDS working group of the Japanese society for transplantation and cellular therapy.
- Evaluation of in vitro rat and human airway epithelial models for acute inhalation toxicity testing.
- The effect of granulocyte-colony stimulating factor, decitabine, and busulfan-cyclophosphamide versus busulfan-cyclophosphamide conditioning on relapse in patients with myelodysplastic syndrome or secondary acute myeloid leukaemia evolving from myelodysplastic syndrome undergoing allogeneic haematopoietic stem-cell transplantation: an open-label, multicentre, randomised, phase 3 trial.
- Prospective comparison of 5- and 7-day administration of azacitidine for myelodysplastic syndromes: a JALSG MDS212 trial.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:86839(Orphanet)
- MONDO:0019454(MONDO)
- GARD:19070(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Q7307573(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
