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Síndrome dor regional complexa
ORPHA:83452CID-10 · G90.6CID-11 · MG30.04DOENÇA RARA
Esta doença tem causa genética. Recomendamos procurar um médico geneticista para diagnóstico, exames genéticos e aconselhamento familiar.
DermatológicoInício todas idadesHerança Unknown
Também conhecida comoCausalgiaDistrofia simpática reflexaSíndrome da dor regional complexaSíndrome dolorosa complexa regionalSDCR

A síndrome da dor regional complexa (SDCR) é uma doença neurológica rara, condição dolorosa e progressiva que corresponde a um grupo de distúrbios caracterizados por uma dor espontânea ou induzida por estímulo desproporcional, acompanhada por uma miríade mista de distúrbios autonômicos e motores, incluindo sintomas como inchaço, alodinia, suprimento sanguíneo da pele e distúrbios tróficos. A SDCR afeta mais frequentemente um dos braços, pernas, mãos ou pés e geralmente ocorre após uma lesão ou trauma nesse membro.

Em construçãohistóricoSugerir correção
Mantido por Agente Raras·Colaborar como especialista →

Introdução

O que você precisa saber de cara

💬
EM LINGUAGEM SIMPLES

A síndrome dor regional complexa é uma condição neurológica rara que causa dores intensas e contínuas em um braço, perna, mão ou pé, geralmente após um trauma ou lesão. A família costuma notar inchaço no membro, vermelhidão, pele seca e uma sensibilidade tão extrema que até toques leves provocam dor (alodinia). A doença não possui um Protocolo Clínico e Diretrizes Terapêuticas (PCDT) próprio nem medicamentos específicos fornecidos pelo SUS, mas o sistema público prevê atendimento em reabilitação para doenças raras. O acompanhamento multidisciplinar e a participação em pesquisas clínicas ajudam no cuidado contínuo e na busca por novas alternativas terapêuticas.

📋
Informacoes curadas por IA — podem conter imprecisoes

A síndrome da dor regional complexa (SDCR) é uma doença neurológica rara, condição dolorosa e progressiva que corresponde a um grupo de distúrbios caracterizados por uma dor espontânea ou induzida por estímulo desproporcional, acompanhada por uma miríade mista de distúrbios autonômicos e motores, incluindo sintomas como inchaço, alodinia, suprimento sanguíneo da pele e distúrbios tróficos. A SDCR afeta mais frequentemente um dos braços, pernas, mãos ou pés e geralmente ocorre após uma lesão ou trauma nesse membro.

Pesquisas ativas
43 ensaios
214 total registrados no ClinicalTrials.gov
Publicações científicas
4.231 artigos
Último publicado: 2026 Apr 17
Medicamentos
2 com registro
Lidotral Five Percent with Menthol (LIDOCAINE HYDROCHLORIDE, MENTHOL), LIDOTHOL (LIDOCAINE AND MENTHOL)

Tem tratamento?

✓ 2 medicamentos específicos desta doença (registro ANVISA, FDA ou SUS/CEAF)
Ver detalhes, fases e interações →
LIDOTRAL FIVE PERCENT WITH MENTHOL (LIDOCAINE HYDROCHLORIDE, MENTHOL)LIDOTHOL (LIDOCAINE AND MENTHOL)

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
Unknown
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Início
All ages
🏥
SUS: Cobertura mínimaScore: 15%
2 procedimentos SIGTAPCID-10: G90.6
🇧🇷Dados SUS / DATASUS
EXAMES E PROCEDIMENTOS RELACIONADOS (2)
•
Sequenciamento completo do exoma (WES)
•
Atendimento em reabilitação — doenças raras
Você se identifica com essa condição?
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🧬
Pele e cabelo
3 sintomas
🦴
Ossos e articulações
2 sintomas

+ 7 sintomas em outras categorias

Características mais comuns

90%prev.
Dor em membro
Muito frequente (99-80%)
55%prev.
Eritema
Frequente (79-30%)
55%prev.
Alterações tróficas relacionadas à dor
Frequente (79-30%)
55%prev.
Pele seca
Frequente (79-30%)
55%prev.
Alodinia
Frequente (79-30%)
55%prev.
Edema pedal
Frequente (79-30%)
12sintomas
Muito frequente (1)
Frequente (11)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 12 características clínicas mais associadas, ordenadas por frequência.

Dor em membroLimb pain
Muito frequente (99-80%)90%
EritemaErythema
Frequente (79-30%)55%
Alterações tróficas relacionadas à dorTrophic changes related to pain
Frequente (79-30%)55%
Pele secaDry skin
Frequente (79-30%)55%
AlodiniaAllodynia
Frequente (79-30%)55%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico4.231PubMed
Últimos 10 anos200publicações
Pico2025118 papers
Linha do tempo
2026Hoje · 2026🧪 2000Primeiro ensaio clínico📈 2025Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
✓Aprovado2
3Fase 36
2Fase 21
1Fase 13
·Pré-clínico88
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 100 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Síndrome dor regional complexa

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

Onde estão os ensaios

Com ensaio aberto em 17 países. O ponto verde marca onde há vaga agora.

🟢 Recrutando agora

32 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

NCT07791966 · Effects of Non-invasive Brain Stimulation on Pain Avoidance …Recrutando
NA🇺🇸 Estados Unidos
NCT07811362 · CRPS-RISE Outcomes RegistryRecrutando
🇺🇸 Estados Unidos
NCT07777081 · How the Brain and Body Recover After a Wrist FractureRecrutando
🇬🇧 Reino Unido
NCT07807852 · ESWT for CRPS-I After Distal Radius FractureRecrutando
NATurkey (Türkiye)
NCT07744269 · CRPS-Hand: Contrast + Compression vs WhirlpoolRecrutando
NATurkey (Türkiye)
NCT07210515 · Evaluation of IV AMBTX-01 (Neridronate) for Treatment of CRP…Recrutando
PHASE3🇺🇸 Estados Unidos
NCT07446712 · Hyperbaric Oxygen Therapy in Complex Regional Pain SyndromeRecrutando
NA🇨🇿 Tchéquia
NCT07361692 · Effectiveness of Transcranial Direct Current Stimulation (tD…Recrutando
NA🇫🇷 França
NCT07473635 · Perineural Incobotulinumtoxin-A for Complex Regional Pain Sy…Recrutando
NA🇩🇰 Dinamarca
NCT07349173 · Peripersonal Space Representation in Upper Limb Segmental Ex…Recrutando
🇫🇷 França
NCT07208825 · The Effectiveness of Conservative Treatment in Patients With…Recrutando
NA🇫🇮 Finlândia
NCT06769373 · The Effects of Whirlpool and Contrast Bath in Patients with …Recrutando
NATurkey (Türkiye)
NCT07129811 · Stellate Ganglion Block in Complex Regional Pain SyndromeRecrutando
NATurkey (Türkiye)
NCT06453447 · Prednisone for CRPS in Distal Radius FractureRecrutando
NA🇨🇦 Canadá
NCT06421350 · Closed Loop Spinal Cord Stimulation for Complex Regional Pai…Recrutando
NA🇺🇸 Estados Unidos
NCT06393101 · The Effects and Mechanisms of a High CBD Cannabis Extract (B…Recrutando
PHASE1🇺🇸 Estados Unidos
NCT05689944 · Dance-therapy and Chronic PainRecrutando
NA🇫🇷 França
NCT05814497 · Supraspinal Processing of Sensory Aspects of PainRecrutando
NA🇺🇸 Estados Unidos
NCT05777889 · Infrared Images for Spinal Cord Stimulation in Complex Regio…Recrutando
🇺🇸 Estados Unidos
NCT04909138 · Intermittent Dosing of Dorsal Root Ganglion Stimulation as a…Recrutando
NA🇺🇸 Estados Unidos
NCT05052736 · Non Invasive Neurostimulation Technology for the Treatment o…Recrutando
NA🇪🇸 Espanha
NCT05034835 · Impact of Compression Garments on Pain in Patients With Comp…Recrutando
NA🇫🇷 França
NCT04144972 · Closed-Loop Deep Brain Stimulation for Refractory Chronic Pa…Recrutando
NA🇺🇸 Estados Unidos
NCT03612193 · Role of the Gut Microbiome in Complex Regional Pain SyndromeRecrutando
🇺🇸 Estados Unidos
NCT03137472 · TMS for Complex Regional Pain SyndromeRecrutando
NA🇺🇸 Estados Unidos
NCT02753335 · Clinical and Cerebral Changes Following Multifaceted Rehabil…Recrutando
NA🇳🇴 Noruega
NCT02502162 · Low-Dose Naltrexone for the Treatment of Complex Regional Pa…Recrutando
NA🇺🇸 Estados Unidos
NCT07785362 · Neuro-modulation of Central Pain Pathways in Non Inflammator…Por convite
NA🇮🇹 Itália
NCT06798493 · CSS-SR Validation StudyPor convite
🇺🇸 Estados Unidos
NCT06306157 · Low Dose Naltrexone Therapy for Complex Regional Pain Syndro…Por convite
PHASE4🇺🇸 Estados Unidos
NCT05477004 · Observational Study of Ketamine Infusions for the Treatment …Por convite
🇺🇸 Estados Unidos
NCT05212571 · Long-term Pain Modulation by Intravenous Esketamine in CRPSPor convite
NA🇳🇱 Países Baixos

Outros ensaios clínicos

214 ensaios clínicos encontrados, 43 ativos.

Distribuição por fase
NCT07858812 · Validity and Reliability of the Turkish Version of the Revis…Em breve
Turkey (Türkiye)
NCT07857733 · Phase 3, Open-Label Extension Study of AMBTX-01 (Neridronate…Em breve
PHASE3
NCT07818174 · Graded Motor Imagery Effects on Body Perception Disturbance …Em breve
NA🇫🇷 França
NCT07636980 · Empowered Relief for CaregiversEm breve
NA🇺🇸 Estados Unidos
NCT07711392 · Transcutaneous Auricular Vagus Nerve Stimulation Added to Re…Em breve
NA
NCT06978608 · Ultrasound and Somatosensory Median Nerve Evaluation in CRPS…Em breve
NCT06987747 · Reducing Pain in Complex Regional Pain Syndrome Using Person…Em breve
NA🇨🇦 Canadá
NCT06470581 · Thoracic Sympathetic Ganglion Block With Botulinum Toxin Typ…Em breve
NA
NCT07838376 · Preceding Pain and Development of Additional Pain in Patient…Ativo
🇬🇧 Reino Unido
NCT05593237 · Transcranial Magnetic Stimulation for Chronic Neuropathic Pa…Ativo
NA🇺🇸 Estados Unidos
NCT03686748 · Two Point DiscriminationAtivo
EARLY_PHASE1🇺🇸 Estados Unidos
NCT07869667 · NEURO-MODULATORY EFFECT OF ELECTRO-ACUPUNCTURE ON COMPLEX RE…Concluído
NA🇪🇬 Egito
NCT07228949 · Complex Regional Pain Syndrome: Analgesic OutcomeConcluído
🇨🇦 Canadá
NCT07610889 · Effects of Motor Imagery Technique With and Without Virtual …Concluído
NAPakistan
NCT07147140 · Physiological Parameters in CRPS Patients Treated With Dorsa…Concluído
NA🇧🇪 Bélgica
NCT07170722 · Sub-threshold DRG Stimulation vs Sham in Established Respond…Concluído
NA🇸🇪 Suécia
NCT07093424 · Relationship Between Complex Regional Pain Syndrome and Magn…Concluído
Turkey (Türkiye)
NCT07332884 · Comparative Effects of Mirror Therapy and Standard Physiothe…Concluído
NAPakistan
NCT06523361 · Contribution of Immersive Virtual Reality to a Standardized …Concluído
NA🇫🇷 França
NCT07570199 · THE EFFECTS OF FUNCTIONAL ELECTRICAL STIMULATION-ASSISTED BI…Concluído
Turkey (Türkiye)
NCT06241820 · The Success of Lumbar Sympathetic Ganglion Block Using Lower…Concluído
NASouth Korea
NCT07370012 · Prism Adaptation Therapy for CRPS Type 1Concluído
NATurkey (Türkiye)
NCT05787119 · Benefit of Augmented Reality Mirror Therapy in Addition to C…Concluído
NA🇫🇷 França
NCT05998369 · Empowered Relief for YouthConcluído
NA🇺🇸 Estados Unidos
NCT05922618 · Pulsed Electromagnetic Fields (PEMFS) in Complex Regional Pa…Concluído
NA🇮🇹 Itália
NCT05852210 · Forward Looking InfraRed Imaging and Severity Score in Compl…Concluído
🇺🇸 Estados Unidos
NCT06587750 · Cognitive Multisensory Rehabilitation for CRPS TreatmentConcluído
NA🇬🇧 Reino Unido
NCT05693337 · Infrared Imaging in Complex Regional Pain SyndromeConcluído
🇺🇸 Estados Unidos
NCT05491499 · Assessing the Impact of Exercise Based Intensive Interdiscip…Concluído
🇺🇸 Estados Unidos
NCT07537465 · Mirror Therapy for Complex Regional Pain Syndrome in Stroke …Concluído
NATurkey (Türkiye)
NCT05888142 · Using Immersive Virtual Reality to Treat Complex Regional Pa…Concluído
NA🇺🇸 Estados Unidos
NCT05459324 · Intraoperative Neuromonitoring Recording With a Novel SCS Pa…Concluído
NA🇺🇸 Estados Unidos
NCT05188040 · Effectiveness of Virtual Reality in Hand TherapyConcluído
NA🇺🇸 Estados Unidos
NCT04650074 · Effectiveness of Ketamine Administered by Mesotherapy in Com…Concluído
PHASE2, PHASE3🇫🇷 França
NCT07062913 · Contrast Compression Therapy for Post-Stroke Complex Regiona…Concluído
NATurkey (Türkiye)
NCT05696587 · Physical and Psychological Changes in CRPS Patients Undergoi…Concluído
NA🇵🇱 Polônia
NCT04732325 · Sensory Testing of Multiple Forms of Spinal Cord Stimulation…Concluído
NA🇺🇸 Estados Unidos
NCT04876989 · The Comparison of Sympathetic Blockade of Stellate Ganglion …Concluído
NASouth Korea
NCT06229015 · Evaluation of Online Tool (E-TOOL SCS) in Spinal Cord Stimul…Concluído
🇮🇹 Itália
NCT04913051 · Interest of Day Hospital Care for Patients With Chronic Regi…Concluído
🇫🇷 França
NCT05160038 · Embodied Virtual Reality for Chronic PainConcluído
NA🇨🇭 Suíça
NCT04849897 · Virtual Reality Guided Imagery for Chronic PainConcluído
NA🇺🇸 Estados Unidos
NCT05108103 · Determination of Longus Colli Muscle Thickness by Ultrasonog…Concluído
Turkey (Türkiye)
NCT04767646 · Evaluation of the Relationship Between the Duration of the E…Concluído
NA🇫🇷 França
NCT04703348 · The Complex Regional Pain Syndrome (CRPS) is a Chronic Pain …Concluído
NA🇫🇷 França
NCT04597866 · Treatment of Complex Regional Pain Syndrome, a Long-term Fol…Concluído
🇸🇪 Suécia
NCT05045625 · Intraoperative Neuromonitoring Recording With a Novel SCS Pa…Concluído
NA🇺🇸 Estados Unidos
NCT03990649 · Study of TAK-935 as an Adjunctive Therapy in Adult Participa…Concluído
PHASE2🇬🇧 Reino Unido
NCT03879538 · Nitrous Oxide for the Treatment of Complex Regional Pain Syn…Concluído
PHASE3🇺🇸 Estados Unidos
NCT04703647 · Longitudinal Follow-up Study About Complex Regional Pain Syn…Concluído
🇨🇭 Suíça
NCT03762213 · Audio-Visual Relaxation Technology for Pediatric Amplified M…Concluído
NA🇺🇸 Estados Unidos
NCT02957240 · Graded Motor Imagery for Women at Risk for Developing Type I…Concluído
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NCT04769128 · THORACIC MANIPULATION and COMPLEX REGIONAL PAIN SYNDROMEConcluído
NA🇪🇬 Egito
NCT03445403 · Offset Analgesia as a Measure of Central Sensitization in Ch…Concluído
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NCT03291197 · Tolerability of Suprascapular and Median Nerve Blocks for th…Concluído
PHASE4🇨🇦 Canadá
NCT04060875 · Research Protocol for Karuna Labs Inc.: Safety and Efficacy …Concluído
🇺🇸 Estados Unidos
NCT04439669 · CRPS - Diagnostics, Pathophysiological Mechanisms, and Respo…Concluído
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NCT03285113 · A Study to Confirm the Safety of High Frequency DRG Stimulat…Concluído
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NCT03377504 · Clinical Evaluation of the Effects of Mirror Therapy in Pati…Concluído
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NCT02901002 · Body Perception and Complex Regional Pain SyndromeConcluído
🇫🇷 França
NCT02972359 · Safety of Intravenous Neridronic Acid in CRPSConcluído
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NCT02800863 · TARGET Post-Approval StudyConcluído
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NCT03203772 · Immersive Virtual Reality for Neuropathic PainConcluído
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NCT02912975 · A Clinical Trial of Mirror Treatment for Phantom PainConcluído
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Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
2.361 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 2.361

#1

A review of research progress of mirror therapy in peripheral nerve injury.

Frontiers in neurology2026

Mirror therapy, as a novel rehabilitation approach, has been widely applied in the treatment of various diseases, including post-stroke limb dysfunction, unilateral neglect, peripheral facial paralysis, complex regional pain syndrome, and childhood cerebral palsy. This study aims to investigate the effectiveness of mirror therapy in treating peripheral nerve injuries, expand the scope of diseases to which mirror therapy can be applied, and provide a novel treatment strategy for peripheral nerve injuries. This study conducted a comprehensive search and analysis of relevant clinical research on mirror therapy for peripheral nerve injuries, providing theoretical and clinical basis for the application of mirror therapy in the treatment of peripheral nerve injuries. Based on a comprehensive analysis of seven clinical studies, it can be concluded that mirror therapy (MT) has a positive effect on improving motor function. Mirror therapy is characterized by its simplicity, economy and non-invasiveness. It is an effective rehabilitation technique for treating peripheral nerve injuries and is suitable for low-cost, long-term home-based rehabilitation. It can be combined with conventional therapies to jointly promote the recovery of motor functions and accelerate the plastic regeneration of nerves.

#2

Long-term relief of CRPS-associated limb dystonia with ketamine infusion.

BMJ case reports2026 Mar 19

Complex regional pain syndrome (CRPS) with associated dystonia is a severely debilitating condition often refractory to conventional management. We present a case report of three patients with chronic, treatment-refractory CRPS-related limb dystonia. Patients were treated with multiday intravenous ketamine infusions (target dose 30 mg/hour) every 3-6 months, supplemented with oral ketamine troches. This treatment protocol resulted in the complete resolution of dystonia in two patients and significant functional improvement in the third. The treatment was well-tolerated, with transient and manageable adverse events including nausea and hypertension. While these findings are limited due to the small sample size and lack of randomisation, this case report presents a potentially promising therapeutic approach for the treatment of CRPS-related motor complications in carefully selected patients with appropriate monitoring.

#3

Beyond the Pain: Rethinking Chronic Pain Management Through Integrated Therapeutic Approaches-A Systematic Review.

International journal of molecular sciences2026 Jan 26

Chronic pain is inherently multifactorial, with biological, psychological, and social factors contributing to neuropathic pain (NP) and central sensitization (CS) syndromes. Comorbidity between functional disorders and the lack of clinical biomarkers adds to the challenge of diagnosis and treatment, leading to frustration for healthcare professionals and patients. Available treatments are limited, increasing patient suffering with personal and financial costs. This systematic review examined multisensory processing alterations in chronic pain and reviewed current pharmacological and non-pharmacological interventions. A structured search was conducted on the PubMed database using the keywords Central Sensitization, Fibromyalgia, Complex Regional Pain Syndrome, and Neuropathic Pain, combined with the keywords Vision, Audition, Olfaction, Touch, Taste, and Proprioception. Papers were then filtered to discuss current treatment approaches. Articles within the last five years, from 2018 to 2023, have been included. Papers were excluded if they were animal studies; investigated tissue damage, disease processes, or addiction; or were conference proceedings or non-English. Results were summarized in table form to allow synthesis of evidence. As this study is a systematic review of previously published research rather than a clinical trial or experimental investigation, the risk of bias was assessed independently by at least two reviewers. 138 studies were identified and analyzed. Of these, 96 focused primarily on treatment options for chronic pain and were analyzed for this systematic review. There were a few emerging themes. No one therapy is effective, so a multidisciplinary approach to diagnosis, including pharmacological, somatic, and psychological treatment, is generally predicted to achieve the best outcomes. Cranial neurovascular compromise, especially of the trigeminal, glossopharyngeal, and potentially the vestibulocochlear nerve, is being increasingly revealed with the advancement of neuroimaging. Cortical and deep brain stimulation to evoke neuroplasticity is an emerging and promising therapy and warrants further investigation. Finally, including patients in their treatment plan allows them control and offers the ability to self-manage their pain. Risk of bias limits the ability to judge the quality of evidence.

#4

The neuroimmune axis and chronic pain disorders.

iScience2026 Jan 16

Both the nervous system and the immune system alert and protect the body against pathogen invasion and damage, but the extent of their interactions have only truly been elaborated in the past few decades. Lymph nodes (LN) are essential immune command centers that modulate the adaptive immune response through the integration of a multitude of signals and activation of T and B lymphocytes. LN are also known to be innervated by sympathetic and sensory nerves. While sympathetic regulation of the immune system is well-established, the impact of sensory neurons has been overlooked. Recently, the sensory neuronal population that innervates popliteal LN has been described in detail, with most cells characterized as peptidergic nociceptors. Of further interest, patients suffering with pain disorders like fibromyalgia, complex regional pain syndrome (CRPS) and hereditary sensory and autonomic neuropathies (HSAN) display both immune and autonomic dysfunction. The localization of nociceptors on LN indicates that there may be a larger impact of sensory neuronal signaling on adaptive immunity than has been explored currently. Therefore, this paper investigates the impact of neural signaling on immunity, specifically the LN and its main cell populations, and aims to address the gaps in our understanding of immune problems featured in pain disorders with aberrant or absent pain.

#5

Efficacy and Safety of Bisphosphonates for Complex Regional Pain Syndrome : A Systematic Review and Meta-analysis.

Annals of internal medicine2026 Feb

Clinical guidelines recommend bisphosphonates for complex regional pain syndrome (CRPS) despite limited evidence of efficacy. To determine the efficacy and safety of bisphosphonates compared with placebo for CRPS. MEDLINE, Embase, Cochrane Central Register of Controlled Trials, and 3 trial registries from inception to 16 September 2025. Randomized controlled trials enrolling adults with CRPS (type I or II) to bisphosphonate treatment or placebo. Primary outcomes were pain intensity and adverse events. Data were synthesized with random-effects meta-analyses. Risk of bias and certainty of evidence were assessed using the Cochrane Risk of Bias 2 Tool and GRADE (Grading of Recommendations Assessment, Development and Evaluation). Eleven trials (754 participants; CRPS type I, 97%), evaluating alendronate (n = 2), clodronate (n = 1), neridronate (n = 5), pamidronate (n = 1), and zoledronate (n = 2), were included. Bisphosphonates may result in little to no difference in pain intensity in the immediate term (≤4 weeks; 0-to-100 scale; mean difference [MD], -9.1 [95% CI, -19.2 to 1.1]; low certainty). In the short term (>4 weeks to 3 months; primary time point), bisphosphonates may reduce pain intensity (MD, -10.0 [CI, -18.9 to -1.1]; low certainty), and in the medium term (>3 to 6 months), they may result in little to no difference in pain intensity (MD, 8.0 [CI, -15.4 to 31.4]; low certainty). The evidence is very uncertain about the effects of bisphosphonates on pain intensity in the long term (>6 months; MD, -2.5 [CI, -19.6 to 14.6]). Bisphosphonates probably increase risk for adverse events (risk ratio, 1.1 [CI, 1.0 to 1.2]; moderate certainty). High heterogeneity and uncertain medium- and long-term effects. Evidence mostly applies to CRPS type I and includes non-U.S.-approved formulations (neridronate, clodronate). Bisphosphonates may reduce CRPS pain intensity in the short term, but treatment is accompanied by adverse events. Future research should resolve uncertainty around which patients with CRPS are most likely to benefit from bisphosphonates. None. (PROSPERO: CRD42024559783).

Publicações recentes

Ver todas no PubMed

📚 EuropePMC2.603 artigos no totalmostrando 197

2026

A review of research progress of mirror therapy in peripheral nerve injury.

Frontiers in neurology
2026

Therapeutic dissociation of CGRP-targeted treatments in migraine and complex regional pain syndrome.

Cephalalgia : an international journal of headache
2026

Therapeutic dissociation of CGRP-targeted treatments in migraine and complex regional pain syndrome: Authors' reply.

Cephalalgia : an international journal of headache
2026

Long-term relief of CRPS-associated limb dystonia with ketamine infusion.

BMJ case reports
2026

Early sensory stabilization and metabolic modulation shape recovery in complex regional pain syndrome.

Pain
2026

Developments in dorsal root ganglion stimulation to treat pain of neuropathic origin.

Expert review of neurotherapeutics
2026

The Withered Arm: Thomas Hardy's chronicle of complex regional pain syndrome.

British journal of pain
2026

Practical tips for paediatricians: It hurts, swells and changes color, maybe its complex regional pain syndrome-Tips for early diagnosis and treatment.

Paediatrics &amp; child health
2026

Functional and radiological outcomes of the all-dorsal technique for scapholunate ligament reconstruction.

The Journal of hand surgery, European volume
2026

Two Case Reports of Tibial Avulsion Fractures of Both Cruciate Ligaments and the Medial Collateral Ligament: A Narrative Review of Current Literature.

Sportverletzung Sportschaden : Organ der Gesellschaft fur Orthopadisch-Traumatologische Sportmedizin
2026

Risk Factors for Spinal Cord Stimulator Explant After Implantation for Neuropathic Pain: A Systematic Review.

Neuromodulation : journal of the International Neuromodulation Society
2026

What Are the Patient-reported Outcomes After Elective Transtibial Amputation? A Comparison of CRPS, Neuropathic Pain, and Other Conditions That Lead to Late Amputation After Limb Salvage.

Clinical orthopaedics and related research
2026

The development of complex regional pain syndrome following distal radius fracture with or without concomitant carpal tunnel release.

Injury
2026

Painful nodules on the feet.

JAAD case reports
2026

Peripheral Nerve Stimulation for the Management of Chronic Pain Syndrome: A Case Study of Complex Regional Pain Syndrome Posttrauma and After Surgery in the Leg.

Pain medicine case reports
2026

Just the Facts: How to diagnose and treat complex regional pain syndrome.

CJEM
2025

Association Between Vitamin D Deficiency and the Development of Complex Regional Pain Syndrome: A Retrospective Case-Control Study.

Acta orthopaedica Belgica
2026

Finger Joint Releases in the Setting of Complex Regional Pain Syndrome: Worthwhile or Risky?

The Journal of hand surgery
2026

Substance Use Associated With Poor 90-Day and 2-Year Postoperative Outcomes After Surgical Fixation of Distal Radius Fracture.

Hand (New York, N.Y.)
2026

Preventive Effects of Avocado/Soybean Unsaponifiables on Complex Regional Pain Syndrome Type I in a Rat Model.

Biomedicines
2026

Intravenous Pamidronate in Persistent Complex Regional Pain Syndrome (CRPS): A Retrospective Observational Study on Effectiveness and Tolerability.

Journal of pain research
2026

Glucagon-Like Peptide-1 Receptor Agonist Use Is Associated With Decreased Incidence of Carpal Tunnel Syndrome in Patients With Type 2 Diabetes: A Propensity-Matched Analysis.

Hand (New York, N.Y.)
2026

Clinical effectiveness of spinal cord stimulation in managing refractory upper-extremity pain.

Neurosurgical review
2026

Incidence proportion of complex regional pain syndrome (CRPS) after distal radius fracture: a population-based register study.

Acta orthopaedica
2026

Long-term efficacy of neuromodulation in chronic pain management: a single-center retrospective study.

Frontiers in pain research (Lausanne, Switzerland)
2026

Double Crush Syndrome in Surgically-Treated Lumbosacral Radiculopathy: Prevalence, Risk Factors, and Clinical Implications.

Spine surgery and related research
2026

The nonhallucinogenic ketamine metabolite (2R,6R)-hydroxynorketamine is a novel analgesic in animal models of pain.

Frontiers in pain research (Lausanne, Switzerland)
2026

Treating CRPS and FNSD in an Adolescent: A Case Study.

Journal of clinical psychology in medical settings
2026

Beyond the Pain: Rethinking Chronic Pain Management Through Integrated Therapeutic Approaches-A Systematic Review.

International journal of molecular sciences
2026

How postmenopausal osteoporosis influences epidemiology and clinical features of CRPS-1.

Journal of bone and mineral metabolism
2026

Sciatic nerve compression as a cause of severe chronic pain after total knee replacement: a case report.

The Knee
2026

Spinal Cord Stimulation in Complex Regional Pain Syndrome: A Narrative Review.

Cureus
2026

Ketamine for acute and chronic pain: beyond anaesthesia.

Pain management
2026

Post-licensure safety surveillance of 9-valent human papillomavirus vaccine using the vaccine adverse event reporting system, 2014-2024.

Frontiers in public health
2026

Clinical Presentation of Shoulder-Hand Syndrome: A Systematic Review.

European journal of pain (London, England)
2025

Mechanisms and clinical progress of spinal cord stimulation in refractory chronic pain: an overview.

Frontiers in neurology
2026

The Emerging Crisis in Non-Prescribed Ketamine Use: A Rapid Attenuation of Depression in Face of Abuse and "Chill-out" or Escapism Drug.

Substance use &amp; misuse
2026

Complex regional pain syndrome should be aggressively treated as soon as it is diagnosed.

Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology
2026

Prescription of Graded Motor Imagery for People With Chronic Pain: A Scoping Review.

European journal of pain (London, England)
2026

Mirror Neurons and Pain: A Scoping Review of Experimental, Social, and Clinical Evidence.

Healthcare (Basel, Switzerland)
2026

Long-Term Outcome of Complex Regional Pain Syndrome versus Limb Pain of Other Origin: Results From a Telephone Survey With up to 5-year Follow-Up.

Pain research &amp; management
2026

Sex differences in pain-related behaviour and the endocannabinoid system following hind limb ischemia-reperfusion injury.

The journal of pain
2026

Combining Robotics and Microbiome Science to Treat Unusual Post-Herpetic Neuralgias Resembling Complex Regional Pain Syndrome.

Pain practice : the official journal of World Institute of Pain
2026

Effects of Motor Imagery on Movement-Based Fear in Musculoskeletal Conditions: A Critically Appraised Topic.

Journal of sport rehabilitation
2026

Weight management for chronic low back pain.

The Cochrane database of systematic reviews
2026

Identification of peripheral pain generators with sigma-1 receptor Positron Emission Tomography/Magnetic Resonance Imaging in complex regional pain syndrome: initial study in a prospective trial.

Pain
2026

Enhancing Functional Outcomes in Distal End Radius Fracture Rehabilitation.

Journal of orthopaedic case reports
2026

Practical Interpretation of Bone Scintigraphy: Metastases, Fractures, and Beyond.

Radiographics : a review publication of the Radiological Society of North America, Inc
2026

"Identifying Social Factors that Stratify Health Opportunities and Outcomes (ISSHOOs) in pain research": explanation and elaboration to support the standardized reporting of equity-relevant data.

Journal of clinical epidemiology
2025

Radiofrequency Ablation for Chronic Pain: Mechanistic Insights and Emerging Innovations.

Cureus
2026

Clodronate and Neridronate: cornerstones of Osteometabolic therapy.

La Clinica terapeutica
2026

The neuroimmune axis and chronic pain disorders.

iScience
2026

Quality matters: Interpreting amputation outcomes in CRPS - Authors reply.

The journal of pain
2025

Stingray Envenomation Resulting in Neuropathy and Complex Regional Pain Syndrome Treated With Peripheral Nerve Stimulation: A Case Report.

Cureus
2025

Altering visual feedback during reaching: no mitigating effect on pain for individuals with complex regional pain syndrome, but visuomotor adaptation is preserved.

Frontiers in human neuroscience
2025

Effective Adolescent Hand CRPS Type 1 Treatment Using Ketamine, Gabapentin, and Supraclavicular Nerve Block Catheter-A Case Report.

Children (Basel, Switzerland)
2025

Memantine and graded motor imagery for complex regional pain syndrome (MEMOIR): study protocol and statistical analysis plan for a decentralised, 2 × 2 factorial randomised trial.

Trials
2026

White Matter Structure in Complex Regional Pain Syndrome: A High Angular Resolution and Fixel-Based Study.

European journal of pain (London, England)
2025

Effect of the combination of acupuncture based on Yuan-Luo Da-Jie-Jing and repetitive transcranial magnetic stimulation on type 1 complex regional pain after stroke: a randomized controlled trial protocol.

Frontiers in neurology
2026

Repurposing osteoporosis medications for other diseases: a narrative review by the European Calcified Tissue Society (ECTS).

Bone
2025

Sustained symptom reduction in complex regional pain syndrome with a novel home-based virtual reality program: a pilot study.

Frontiers in neurology
2025

Revision of an Eight-lead Boston Scientific® Spinal Cord Stimulator With Epidural Migration: A Case Report.

Cureus
2025

Nociception level index as a tool of measuring pain objectively in patients with complex regional pain syndrome: a feasibility study.

Frontiers in pain research (Lausanne, Switzerland)
2026

Efficacy and Safety of Bisphosphonates for Complex Regional Pain Syndrome : A Systematic Review and Meta-analysis.

Annals of internal medicine
2026

Annals Video Summary - Efficacy and Safety of Bisphosphonates for Complex Regional Pain Syndrome: A Systematic Review and Meta-analysis.

Annals of internal medicine
2025

Bilateral Upper and Lower Limb Complex Regional Pain Syndrome (CRPS) in a Lung Cancer Survivor: Diagnostic and Interventional Challenges in the Setting of Radiculopathy and Prior Radiotherapy.

Cureus
2026

Unmasking the pain in a diabetic foot.

Diabetic medicine : a journal of the British Diabetic Association
2026

Evaluating the Statistical Robustness of Randomized Controlled Trials of Spinal Cord Stimulation for Pain through the Use of Fragility Index.

Anesthesiology
2025

Complex Regional Pain Syndrome.

The New England journal of medicine
2025

White matter tracts involved in complex regional pain syndrome after subcortical stroke.

Frontiers in neurology
2025

Complex regional pain syndrome and migraine: Clinical relationships and possible common aetiology.

Cephalalgia : an international journal of headache
2025

Peripheral Neuromodulation: Type 2 Complex Regional Pain Syndrome Secondary to an Excisional Biopsy.

Cureus
2025

Treatment of Chronic Achilles Tendon Ruptures by Endoscopic Flexor Hallucis Longus Transfer with Double Fixation: Results in 36 Patients at a mean follow-up of 38 Months (range, 12-58 Months).

Orthopaedics &amp; traumatology, surgery &amp; research : OTSR
2026

Exploring the Psychiatric Burden of Complex Regional Pain Syndrome Type I After Long-bone Fractures.

The Journal of the American Academy of Orthopaedic Surgeons
2026

Challenges in Diagnosis and Management of Complex Regional Pain Syndrome: Insights From a Retrospective 9-Year Review in an Academic Medical Center.

The American journal of occupational therapy : official publication of the American Occupational Therapy Association
2025

Assessment of Three Regimens of Ketamine Infusion in Complex Regional Pain Syndrome: A Randomized Prospective Comparative Study.

Pain physician
2026

Spatial imaging analysis of cutaneous nerve-myeloid cell interactions in chronic complex regional pain syndrome.

Pain
2025

Functional Bracing Versus Rigid Plaster Casting for the Immobilization of Colles Fractures in Adults: A Meta-Analysis of Randomized Controlled Trials.

Hand (New York, N.Y.)
2026

Heterogeneity matters: Interpretating amputation outcomes in CRPS.

The journal of pain
2025

Long-term outcomes of amputation in the treatment of complex regional pain syndrome : a case series.

The bone &amp; joint journal
2025

Bone marrow mesenchymal stem cells attenuate pain and modulate peripheral sodium channel activity in a rat model of complex regional pain syndrome type I.

Cell transplantation
2025

Effects of human papillomavirus (HPV) vaccination programmes on community rates of HPV-related disease and harms from vaccination.

The Cochrane database of systematic reviews
2025

Corrigendum: Complex Regional Pain Syndrome Following Distal Radius Fracture: Does Surgical Method Matter?

Journal of wrist surgery
2025

Effectiveness of contrast compression therapy for post-stroke complex regional pain syndrome: a randomized control trial.

Topics in stroke rehabilitation
2025

Neurological Phenotypes of SOCS1 Haploinsufficiency: Insights from Functional and Histological Investigations.

Journal of clinical immunology
2026

Item Reduction and Scoring of the Pediatric PainSCAN ©: A Screening Tool for Pediatric Neuropathic Pain and Complex Regional Pain Syndrome.

The Clinical journal of pain
2025

Intact endogenous pain inhibition in complex regional pain syndrome type 1.

Pain reports
2025

Association Between Chronic Pain and Jumping-to-Conclusions Behaviour.

Pain research &amp; management
2025

Novel approaches for drug development against chronic primary pain: A systematic review.

British journal of pharmacology
2025

Thoracic spinal cord compression due to excessive scarring around surgical paddle epidural electrodes. Report of two cases with literature review.

Folia neuropathologica
2025

Clinical Outcomes Associated with Stellate Ganglion Block Across Multiple Pain Phenotypes.

Journal of clinical medicine
2025

Intramedullary nailing versus plate fixation for humeral shaft fractures in geriatric patients: a retrospective cohort study assessing functional outcomes and complication rates.

BMC musculoskeletal disorders
2026

MRI has limited accuracy in diagnosing complex regional pain syndrome Type 1 - a systematic review of the literature.

European journal of radiology
2026

Altered cortical alpha modulations and connectivity in complex regional pain syndrome.

The journal of pain
2025

Immunological Therapy in Persistent Complex Regional Pain Syndrome: A Systematic Review and Narrative Synthesis.

European journal of pain (London, England)
2026

Cross-education after forearm fracture: a randomised controlled trial.

Irish journal of medical science
2025

Debunking Myths and Patient Education About Complex Regional Pain Syndrome Using Popular Generative Artificial Intelligence Chatbots.

A&amp;A practice
2025

TRPV4 Channel Participates in the Nociception and Spinal Neuroinflammation Involved in a Model of Complex Regional Pain Syndrome Type I (CPIP) in Mice.

Journal of neurochemistry
2026

Listening to the silence of pain narratives: A qualitative study of epistemic injustice in patient-clinician communication on medically unexplained chronic pain in Japan.

Patient education and counseling
2025

Retained Endovascular Catheter Causing Erosive Cyst Formation of the Cuboid After Embolization: A Case Report.

JBJS case connector
2025

Impaired bone mineral density in patients with complex regional pain syndrome.

Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry
2025

Identifying recommendations to improve therapy-led management of complex regional pain syndrome in England.

British journal of pain
2025

Complex Regional Pain Syndrome With Central and Peripheral Nervous System Involvement in a Patient With Metastatic Lung Cancer.

Cureus
2025

Pyrocarbon capitate resurfacing implant combined with proximal row carpectomy for advanced wrist osteoarthritis.

Hand surgery &amp; rehabilitation
2025

Mortality Outcomes After Spinal Cord Stimulation: A 10-Year Survival Analysis of 330 Patients With Chronic Neuropathic Pain.

Neurosurgery
2026

Small nerve fibre pathology in non-neuropathic chronic pain conditions: a systematic review and meta-analysis.

Pain
2025

New Zealand Survey of the Diagnosis and Treatment Experiences of People With Upper Limb Complex Regional Pain Syndrome.

Pain practice : the official journal of World Institute of Pain
2025

What's in a name? Complex Regional Pain Syndrome, the ICD-11, and the power of taxonomy.

Journal of psychosomatic research
2025

Comparison Between Surgical and Percutaneous Paddles in Spinal Cord Stimulation for Chronic Neuropathic Pain.

Journal of clinical medicine
2025

Neurocognitive Interventions Informed by Cognitive-Behavioral Therapy (CBT) Principles and Physical Exercise for Complex Regional Pain Syndrome: A Systematic Review.

Journal of clinical medicine
2025

Stage 2a IDEAL evaluation of a third-generation biocomposite suture anchor in arthroscopic rotator cuff repair: subgroup cohort analysis of the PRULO registry with 12-month follow up.

BMC musculoskeletal disorders
2025

Spinal Cord Stimulation for Painful Neuropathic Cauda Equina Syndrome Following Ballistic Penetrating Lumbar Spine Injury: Proof-of-Concept Case.

Military medicine
2025

Ultrasound-guided Percutaneous Ulnar Nerve Release at the Elbow: A Stepwise Approach.

Techniques in hand &amp; upper extremity surgery
2026

Reducing time from presentation to diagnosis of scaphoid fractures with cone beam CT: a before-and-after study.

Emergency medicine journal : EMJ
2025

Risk factors for complex regional pain syndrome after distal radius fracture following nonoperative management: A retrospective case-control study.

Injury
2026

Complex regional pain syndrome evolution is determined by both biological and psychosocial factors: a 1-year prospective observational study.

Pain
2025

Optimising clinical trial methods for complex regional pain syndrome: a methodological framework (OptiMeth-CRPS).

Pain reports
2025

Amputation for complex regional pain syndrome: A systematic review.

The journal of pain
2025

The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.

BMC musculoskeletal disorders
2025

An Unusual Challenging Case of Complex Regional Pain Syndrome Involving all 4 Limbs: A Case Report.

Pain medicine case reports
2025

Peripheral Neuromodulation for Treatment of Upper Extremity Complex Regional Pain Syndrome Following Peripherally Inserted Central Catheter Placement: A Case Report.

Pain medicine case reports
2026

Topical analgesics for neuropathic pain: an evidence-informed guide for the practicing clinician.

Pain medicine (Malden, Mass.)
2026

Evaluation of K-wires splinting of first and second metatarsals following proximal open wedge osteotomy for hallux valgus correction.

The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
2025

Battery Life of Pulse Generators in Spinal Cord Stimulation: Analysis and Comparison Between Surgical and Percutaneous Leads in Energy Efficiency.

Journal of clinical medicine
2025

The Warm Phase of CRPS Type-1: Is It Time to Review the Budapest Criteria?

Diagnostics (Basel, Switzerland)
2025

Brain biomarkers for CRPS.

Neuroscience and biobehavioral reviews
2025

Pain and lymphoedema: a challenging combination.

British journal of community nursing
2025

Prevalence and characteristics of neuropathic pain in adolescent survivors of childhood cancer.

Journal of cancer survivorship : research and practice
2025

Complex regional pain syndrome after transradial coronary intervention.

Kardiologia polska
2025

Balancing the controversy: long-term outcomes of amputation in patients with complex regional pain syndrome (CRPS) - an infographic.

Regional anesthesia and pain medicine
2025

Comprehensive Mechanisms and Non-Invasive Treatment for Complex Regional Pain Syndrome: A Narrative Review.

Journal of pain research
2025

High Radial Artery Puncture Reduces CRPS Risk for Women: A Retrospective Case Series.

Journal of clinical medicine
2025

Diagnostic Criteria and Technical Evaluation of Complex Regional Pain Syndrome: A Narrative Review.

Diagnostics (Basel, Switzerland)
2025

Interdisciplinary management of paediatric chronic and complex pain: the experience of a specialised outpatient clinic in Italy.

European journal of pediatrics
2025

Prophylaxis Against Complex Regional Pain Syndrome Recurrence with Vitamin C in Total Knee Arthroplasty: A Propensity Score-Matched Analysis of 960 Cases.

The Journal of bone and joint surgery. American volume
2025

A Model of Body Perception Disturbances in Chronic Limb Pain: The Predictive Role of Kinesiophobia, Depersonalization and Symptom Severity.

European journal of pain (London, England)
2025

The Analgesic Efficacy of Therapies Used for Complex Regional Pain Syndrome: A Systematic Review.

Cureus
2025

Patients with vitamin D deficiency are more likely to develop complex region pain syndrome after extremity fractures: a large database propensity-matched cohort study.

European journal of orthopaedic surgery &amp; traumatology : orthopedie traumatologie
2025

UK Medical Cannabis Registry: A Clinical Outcomes Analysis for Complex Regional Pain Syndrome.

Brain and behavior
2025

Feasibility study of a home-based sensory training system (STS) device for type 1 complex regional pain syndrome in England: Lessons learnt.

British journal of pain
2025

The Incidence of Eosinophilia in Refractory Chronic Pain Requiring Neuromodulation.

Neuromodulation : journal of the International Neuromodulation Society
2025

Managing Allodynia in Complex Regional Pain Syndrome: An Integrated Rehabilitation Approach.

Pain management nursing : official journal of the American Society of Pain Management Nurses
2025

Tailoring Treatment in Complex Regional Pain Syndrome: A Comparative Study of Therapeutic Approaches in Complex Rehabilitation.

Pharmaceuticals (Basel, Switzerland)
2026

Prediction of Response to Spinal Cord Stimulation Using Machine Learning Based on Radiomics and Patient-Reported Outcomes.

Neurosurgery
2025

Comparison of the therapeutic effects of modified 15-mm incision minimally invasive approach with the conventional approach in the treatment of AO 23-B3 distal radius fractures.

Injury
2025

[Vitamin C in Complex Regional Pain Syndrome in Patients with Distal Radius Fracture].

Revista brasileira de ortopedia
2025

Vitamin C in Complex Regional Pain Syndrome in Patients with Distal Radius Fracture.

Revista brasileira de ortopedia
2026

Progress in Diagnosis and Treatment of Limb Pain in Hemodialysis Patients With an Arteriovenous Fistula.

Hemodialysis international. International Symposium on Home Hemodialysis
2026

Invited Commentary: Refining the Role of Peripheral Nerve Surgery in Patients Labeled with Complex Regional Pain Syndrome.

Journal of the American College of Surgeons
2025

Long-term outcomes of amputation in patients with complex regional pain syndrome (CRPS): a mixed-methods study.

Regional anesthesia and pain medicine
2025

Ketamine and other NMDA receptor antagonists for chronic pain.

The Cochrane database of systematic reviews
2026

Peripheral Nerve Surgery in Patients with a Label of Complex Regional Pain Syndrome in the Extremities.

Journal of the American College of Surgeons
2025

A Case of Complex Regional Pain Syndrome With Hypermobile Ehlers-Danlos Syndrome and Mast Cell Activation Syndrome: The Role of Unconventional Therapies.

Cureus
2025

Resting-State Brain Activity in Acute and Chronic Complex Regional Pain Syndrome.

The European journal of neuroscience
2025

A narrative review of persistent pain and overall quality of life after temporomandibular joint replacement.

Journal of stomatology, oral and maxillofacial surgery
2026

Do nerve resection, amputation, and immunotherapy relieve causalgia in the long term?

Pain
2025

Open Lift, Drill, Fill, and Fix (LDFF) for Chronic Osteochondral Lesions of the Talus: Favorable 2-Year Clinical Outcomes.

Orthopaedic journal of sports medicine
2025

Novel Concepts in Headache Surgery: Case Report Incorporating Interdisciplinary Care for Complex Head and Neck Pain with Cervical Dystonia.

Plastic and reconstructive surgery. Global open
2025

Diagnostic Guidance for Chronic Complex Regional Pain Syndrome Type I and Type II from The American Society of Interventional Physicians (ASIPP).

Pain physician
2025

Beyond Anesthesia: Ketamine's Expanding Role in Chronic Pain and Psychiatric Disorders.

Journal of integrative neuroscience
2025

Neuronal Reg3β/macrophage TNF-α-mediated positive feedback signaling contributes to pain chronicity in a rat model of CRPS-I.

Science advances
2025

Complex regional pain syndrome in an adolescent with conservative treatment of a scaphoid distal pole fracture.

Radiology case reports
2025

Characterizing the neurophysiology of complex regional pain syndrome using transcranial magnetic stimulation.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
2025

The Multimodal Rehabilitation of Complex Regional Pain Syndrome and Its Contribution to the Improvement of Visual-Spatial Memory, Visual Information-Processing Speed, Mood, and Coping with Pain-A Nonrandomized Controlled Trial.

Brain sciences
2025

Supraspinal Mechanisms of Spinal Cord Stimulation in Pain Mitigation: A Systematic Review.

Cureus
2025

Intramuscular Botulinum Toxin for Complex Regional Pain Syndrome: A Narrative Review of Published Cases.

Toxins
2025

Complex regional pain syndrome of wrist and hand following distal radius fracture: A long-term follow-up study: 16 years (range 10-22 years).

Journal of hand and microsurgery
2025

Dorsal root ganglion stimulation for multifactorial refractory foot pain: A case report.

Interventional pain medicine
2025

Degenerative Cervical Myelopathy in a Patient With a Pre-existing Cervical Spinal Cord Stimulator: A Case Report.

Cureus
2025

Evaluation of the efficacy and tolerance of pamidronate in complex regional pain syndrom type 1.

Scientific reports
2025

Effects of transcutaneous electrical nerve stimulation in complex regional pain syndrome: a systematic review.

Pain management
2025

Arthroscopic techniques in ankle surgery.

Operative Orthopadie und Traumatologie
2025

Additional evidence from a case report supports a novel hypothesis on the association between complex regional pain syndrome and lymphedema.

Frontiers in pain research (Lausanne, Switzerland)
2025

Complex regional pain syndrome and use of psychotropic drugs as a proxy for psychological health.

Scientific reports
2025

Spinal Mechanisms of Pain Modulation by Spinal Cord Stimulation: A Systematic Review.

Cureus
2025

Lower Extremity Nerve Decompression to Treat Complex Regional Pain Syndrome: A Case Report in Pediatric Age Group.

Microsurgery
2025

Feasibility, acceptability, patient experience, and preliminary efficacy of a virtual reality guided imagery intervention for chronic pain.

Frontiers in digital health
2025

Spinal cord stimulation for chronic pain: a retrospective cohort study of patients from a Canadian tertiary centre.

Canadian journal of anaesthesia = Journal canadien d'anesthesie
2025

User-Driven Development of a Digital Behavioral Intervention for Chronic Pain: Multimethod Multiphase Study.

JMIR formative research
2025

Cognitive Function in Patients With Complex Regional Pain Syndrome (CRPS).

European journal of pain (London, England)
2025

Reliability and validity of the Pediatric PainSCAN: a screening tool for pediatric neuropathic pain and complex regional pain syndrome.

Pain
2025

Risk factors analysis of post-stroke complex regional pain syndrome in patients with first-ever subacute stroke.

Clinical neurology and neurosurgery
2025

Penile Pain With Allodynia Following Spinal Cord Stimulation (SCS) Implant: A Case Report.

Pain medicine case reports
2025

Cervical Spinal Cord Stimulator Malfunction Secondary to Lead Fracture.

Pain medicine case reports
2025

Outcome of Carpal Tunnel Release with Longitudinal Mini Incision: A Prospective Cohort.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
2025

Expanding Access to Minor Hand Surgery Procedures in Underrepresented Patient Populations: Safety and Efficacy of a Minor Procedure Clinic in an Urban Safety-Net Hospital.

Journal of the American Academy of Orthopaedic Surgeons. Global research &amp; reviews
2025

Living well with complex regional pain syndrome: a qualitative exploration of lived experiences.

Disability and rehabilitation
2024

Successful Pain Management of Uncontrollable Left Wrist Pain With Peripheral Nerve Stimulation Following Failed Surgeries: A Case Report.

Pain medicine case reports
2024

Long-Term Efficacy of a Novel Extraforaminal Approach for Nerve Root Stimulation in Complex Regional Pain Syndrome: A Case Report.

Pain medicine case reports
2024

Effective Sufentanil Intrathecal Pump Treatment in a Patient With Refractory Complex Regional Pain Syndrome: A Case Report.

Pain medicine case reports
2024

Dorsal Root Ganglion Stimulation as a Treatment for Chronic Refractory Groin Pain: A Case Series.

Pain medicine case reports
2025

A Linguistic Analysis of Future Perceptions of Parents of Adolescents With Complex Regional Pain Syndrome and Parents of Pain-Free Peers.

European journal of pain (London, England)
2025

Predictive Factors of Successful Spinal Cord Stimulation in Patients with Chronic Pain: A Retrospective Cohort Study.

Brain sciences
2025

Are Cannabis-Based Medicines a Useful Treatment for Neuropathic Pain? A Systematic Review.

Biomolecules
2026

Increased motor cortex excitability in chronic complex regional pain syndrome.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
2025

Bone mineral density is associated with pre-treatment pain levels of complex regional pain syndrome type 1 and predicts the response to N-containing bisphosphonates.

Clinical and experimental rheumatology
2025

Limited palmar fasciectomy combined with Z-plasty for Dupuytren's disease: A 56 cases review.

Hand surgery &amp; rehabilitation
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Associações

Organizações que acompanham esta doença — pra ter apoio e orientação

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Doença com base genética

Um médico geneticista pode ajudar no diagnóstico de Síndrome dor regional complexa e no aconselhamento genético da família.

Vai consultar um especialista? Confirme o registro dele no conselho.
Conselhos e sociedades

Doenças relacionadas

Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico

Perguntas frequentes

O que as famílias mais perguntam sobre esta doença — cada resposta com a fonte de onde saiu

Respostas geradas por IA a partir das fontes citadas

A síndrome dor regional complexa é caracterizada como uma condição neurológica crônica e progressiva nos registros médicos. O manejo concentra-se em procedimentos de reabilitação e controle dos sintomas, sem menção a cura definitiva nos catálogos clínicos.

Referências

Fontes citadas no texto, publicações do grafo e bases de dados usadas neste verbete

10 publicações do grafo RarasNet (PubMed) · 6 bases de dados. Títulos, periódicos e PMIDs vêm direto da fonte, sem intermediação de IA.

  1. ORPHA:83452
    Orphanet
  2. GARD:4647
    GARD (NIH)
  3. Q1066311
    Wikidata

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Citar este verbete

Raras. (s.d.). Síndrome dor regional complexa. Em Raras — Enciclopédia de Doenças Raras do Brasil. https://raras.org/doenca/sindrome-dor-regional-complexa

Formato APA. Conteúdo sob CC BY 4.0 — reuso livre com atribuição.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Síndrome dor regional complexa
Compêndio · Raras BR

Síndrome dor regional complexa

ORPHA:83452 · MONDO:0019369
🇧🇷 Brasil SUS
SIGTAP
2 procedimentos
Geral
Prevalência
Unknown
Herança
Not applicable
CID-10
G90.6 · Transtornos do sistema nervoso autônomo
CID-11
Ensaios
43 ativos
Início
All ages
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C0458219
EuropePMC
Wikidata
Wikipedia
Papers 10a

📋 Origem dos dados

Esta página agrega dados de fontes públicas e oficiais. Dados sobre cobertura no SUS (PCDT, CEAF) são verificados ativamente por agente proativo (ver badge no infobox). Demais dados têm atribuição de fonte + data da última sincronização — clique para abrir o original.

Doença rara (ontologia)
fonte: Orphanet
Identificador unificado
fonte: MONDO
Indexação biomédica
fonte: MeSH (NLM)
Dado público estruturado
fonte: Wikidata
Medicamentos aprovados FDA
fonte: FDA OpenFDA
Rara