A hemocromatose neonatal é uma doença em que o corpo acumula ferro demais. Nesta forma de hemocromatose, o excesso de ferro começa antes do nascimento. Essa doença costuma piorar rapidamente e causa problemas no fígado que são visíveis no nascimento ou no primeiro dia de vida. Existem também outras formas de hemocromatose. Para saber mais sobre essas outras formas, clique nos nomes das doenças listadas abaixo: Hemocromatose tipo 1 Hemocromatose tipo 2 Hemocromatose tipo 3 Hemocromatose tipo 4
Introdução
O que você precisa saber de cara
A hemocromatose neonatal é uma doença em que o corpo acumula ferro demais. Nesta forma de hemocromatose, o excesso de ferro começa antes do nascimento. Essa doença costuma piorar rapidamente e causa problemas no fígado que são visíveis no nascimento ou no primeiro dia de vida. Existem também outras formas de hemocromatose. Para saber mais sobre essas outras formas, clique nos nomes das doenças listadas abaixo: Hemocromatose tipo 1 Hemocromatose tipo 2 Hemocromatose tipo 3 Hemocromatose tipo 4
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 11 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 24 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Nenhum gene associado encontrado
Os dados genéticos desta condição ainda estão sendo catalogados.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Hemocromatose neonatal
Centros de Referência SUS
21 centros habilitados pelo SUS para Hemocromatose neonatal
Centros para Hemocromatose neonatal
Detalhes dos centros
Hospital Universitário Prof. Edgard Santos (HUPES)
R. Dr. Augusto Viana, s/n - Canela, Salvador - BA, 40110-060 · CNES 0003808
Serviço de Referência
Hospital de Apoio de Brasília (HAB)
AENW 3 Lote A Setor Noroeste - Plano Piloto, Brasília - DF, 70684-831 · CNES 0010456
Serviço de Referência
Hospital Estadual Infantil e Maternidade Alzir Bernardino Alves (HIABA)
Av. Min. Salgado Filho, 918 - Soteco, Vila Velha - ES, 29106-010 · CNES 6631207
Serviço de Referência
Hospital das Clínicas da UFG
Rua 235 QD. 68 Lote Área, Nº 285, s/nº - Setor Leste Universitário, Goiânia - GO, 74605-050 · CNES 2338424
Serviço de Referência
Hospital das Clínicas da UFMG
Av. Prof. Alfredo Balena, 110 - Santa Efigênia, Belo Horizonte - MG, 30130-100 · CNES 2280167
Serviço de Referência
NUPAD / Faculdade de Medicina UFMG
Av. Prof. Alfredo Balena, 189 - 5 andar - Centro, Belo Horizonte - MG, 30130-100 · CNES 2183226
Serviço de Referência
Hospital Universitário João de Barros Barreto
R. dos Mundurucus, 4487 - Guamá, Belém - PA, 66073-000 · CNES 2337878
Serviço de Referência
Hospital de Clínicas da Universidade Federal de Pernambuco
Av. Prof. Moraes Rego, 1235 - Cidade Universitária, Recife - PE, 50670-901 · CNES 2561492
Atenção Especializada
Instituto de Medicina Integral Prof. Fernando Figueira (IMIP)
R. dos Coelhos, 300 - Boa Vista, Recife - PE, 50070-902 · CNES 0000647
Serviço de Referência
Hospital de Clínicas da UFPR
R. Gen. Carneiro, 181 - Alto da Glória, Curitiba - PR, 80060-900 · CNES 2364980
Serviço de Referência
Hospital Universitário Pedro Ernesto (HUPE-UERJ)
Blvd. 28 de Setembro, 77 - Vila Isabel, Rio de Janeiro - RJ, 20551-030 · CNES 2280221
Serviço de Referência
Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira (IFF/Fiocruz)
Av. Rui Barbosa, 716 - Flamengo, Rio de Janeiro - RJ, 22250-020 · CNES 2269988
Serviço de Referência
Hospital Universitário Onofre Lopes (HUOL)
Av. Nilo Peçanha, 620 - Petrópolis, Natal - RN, 59012-300 · CNES 2408570
Atenção Especializada
Hospital São Lucas da PUCRS
Av. Ipiranga, 6690 - Jardim Botânico, Porto Alegre - RS, 90610-000 · CNES 2232928
Serviço de Referência
Hospital de Clínicas de Porto Alegre (HCPA)
Rua Ramiro Barcelos, 2350 Bloco A - Av. Protásio Alves, 211 - Bloco B e C - Santa Cecília, Porto Alegre - RS, 90035-903 · CNES 2237601
Serviço de Referência
Hospital Universitário da UFSC (HU-UFSC)
R. Profa. Maria Flora Pausewang - Trindade, Florianópolis - SC, 88036-800 · CNES 2560356
Serviço de Referência
Hospital das Clínicas da FMUSP
R. Dr. Ovídio Pires de Campos, 225 - Cerqueira César, São Paulo - SP, 05403-010 · CNES 2077485
Serviço de Referência
Hospital de Clínicas da UNICAMP
R. Vital Brasil, 251 - Cidade Universitária, Campinas - SP, 13083-888 · CNES 2748223
Serviço de Referência
Hospital de Clínicas de Ribeirão Preto (HCRP-USP)
R. Ten. Catão Roxo, 3900 - Vila Monte Alegre, Ribeirão Preto - SP, 14015-010 · CNES 2082187
Serviço de Referência
Instituto da Criança e do Adolescente (ICr-HCFMUSP)
Av. Dr. Enéas Carvalho de Aguiar, 647 - Cerqueira César, São Paulo - SP, 05403-000 · CNES 2081695
Serviço de Referência
UNIFESP / Hospital São Paulo
R. Napoleão de Barros, 715 - Vila Clementino, São Paulo - SP, 04024-002 · CNES 2688689
Serviço de Referência
Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
Pesquisa e ensaios clínicos
1 ensaios clínicos encontrados.
Publicações mais relevantes
Gestational alloimmune liver disease reconsidered: Advocating for a new nomenclature and enhanced diagnosis accuracy.
Gestational alloimmune liver disease (GALD), previously known as neonatal hemochromatosis, is a rare antenatal immune condition in which maternal antibodies target the fetal liver, leading to a spectrum of liver injury. Although GALD in the leading cause of neonatal liver failure, recent evidence highlights its association with milder phenotypes. A maternal history of miscarriages or stillbirths may be present. GALD is characterized by hepatic and extrahepatic iron overload sparing the reticuloendothelial system. The transferrin saturation coefficient is the most reliable marker of iron overload, and salivary gland biopsy may assist in diagnosis. Early recognition is crucial, as GALD is treatable. Management involves both acute neonatal treatment and preventive strategies for future pregnancies. Recurrence may reach 90% but can be effectively prevented with antenatal intravenous immunoglobulin therapy. We report four cases of GALD managed in gastroenterology unit of the Sainte-Justine center in Montreal, Canada. A literature review was also conducted to explore the etiopathogenesis, diagnosis, treatment options, and outcomes of the GALD. A total of 39 studies published between 2008 and 2024 were identified through PubMed, Google Scholar, and EMBASE using the terms "gestational alloimmune liver disease" and "neonatal hemochromatosis".
Intrauterine high-dose intravenous immunoglobulin therapy during pregnancy for women with a history of pregnancy ending in documented neonatal haemochromatosis (NH001): study protocol.
Neonatal haemochromatosis, considered to be a gestational alloimmune liver disease (NH-GALD), is a rare but serious disease that results in fulminant hepatic failure. The recurrence rate of NH-GALD in a subsequent infant of a mother with an affected infant is 70%-90%. Recently, antenatal maternal high-dose intravenous immunoglobulin (IVIG) therapy has been reported as being effective for preventing recurrence of NH-GALD in a subsequent infant. However, no clinical trial has been conducted to date. This is a multicentre open-label, single-arm study of antenatal maternal high-dose IVIG therapy in pregnant women with a history of documented NH in a previous offspring. The objective of this study is to evaluate the efficacy and safety of antenatal maternal high-dose IVIG therapy in preventing or reducing the severity of alloimmune injury to the fetal liver. The clinical trial is being performed in accordance with the Declaration of Helsinki. The trial protocol was approved by the Clinical Research Review Board at four hospitals. Before enrolment, written informed consent would be obtained from eligible pregnant women. The results are expected to be published in a scientific journal. 28 October 2024, V.8.0. jRCT1091220353.
Correction: Neonatal Lupus presenting with neonatal hemochromatosis-like liver disease that responded to steroids: a case report.
Maternal Immunoglobulin Treatment of Gestational Alloimmune Liver Disease to Prevent Neonatal Liver Failure: A Single Center Case Series.
Gestational alloimmune liver disease (GALD), previously known as neonatal hemochromatosis, is a rare maternal-fetal alloimmune disease causing severe fetal-neonatal liver failure. Understanding the immunological origin resulted in the concept of treatment with high-dose intravenous immunoglobins (IVIG) during gestation. This retrospective single-center cohort study consists of seven women with index cases of GALD, followed by a total of ten IVIG-treated singleton pregnancies. Out of seven index pregnancies, five resulted in neonatal deaths. In a total of ten subsequent pregnancies all seven women at risk received antenatal IVIG (1g/kg body weight weekly) starting at median 14 weeks of gestation. Pregnancy courses were uneventful, except for one case of fetal growth restriction and preterm delivery due to severe preeclampsia. No severe maternal adverse effects of repetitive IVIG (median 23 applications) were observed. None of the infants from IVIG-treated women developed severe GALD. Two out of ten neonates displayed slightly abnormal laboratory parameters but did not require exchange transfusion or any other specific treatment. Based on standard laboratory data, we developed a scoring method to identify neonates at risk for GALD-associated liver failure. This case series indicates that weekly antenatal IVIG treatment is highly efficient to prevent GALD-associated neonatal liver failure. In contrast to other cases series, there were no major maternal side effects. An introduced novel laboratory scoring system to decide on early postnatal intervention requires validation in a larger number of neonates.
Successful IVIG Treatment in Neonatal Hemochromatosis Without Extrahepatic Siderosis: A Case Report.
Background and Clinical Significance: Neonatal hemochromatosis is a rare iron overload disorder that causes severe liver injury in newborns, typically with extrahepatic siderosis. Diagnosis of neonatal hemochromatosis is usually confirmed through a biopsy and MRI, demonstrating deposition of iron and liver failure. However, in severe patients who are not able to undergo biopsy, the diagnostic and management method remains unknown. Case Presentation: We present an unusual case of neonatal hemochromatosis without extrahepatic iron deposition in a 9-day-old male who showed signs of liver failure and respiratory distress. This case suggests that when the risks of biopsy outweigh its benefits, a diagnosis may be reached based on clinical evaluation and MRI findings. Early high-dose intravenous immunoglobulin therapy improved liver function and led to recovery, highlighting the need for early therapeutic intervention in neonatal hemochromatosis. Conclusions: This case highlights that the absence of extrahepatic siderosis cannot exclude a diagnosis of neonatal hemochromatosis, and high doses of IVIG should be administered promptly when neonatal hemochromatosis is suspected to maximize therapeutic effectiveness.
Publicações recentes
Severe Congenital Systemic Juvenile Xanthogranuloma With Neonatal Acute Liver Failure, Neonatal Hemochromatosis and Placental Infiltration.
A Non-Fetal Chronic Residual Inflammatory Liver Phenotype After Transient Abnormal Myelopoiesis in Down Syndrome.
Maternal Immunoglobulin Treatment of Gestational Alloimmune Liver Disease to Prevent Neonatal Liver Failure: A Single Center Case Series.
Gestational alloimmune liver disease reconsidered: Advocating for a new nomenclature and enhanced diagnosis accuracy.
📖 RevisãoSuccessful IVIG Treatment in Neonatal Hemochromatosis Without Extrahepatic Siderosis: A Case Report.
📚 EuropePMC146 artigos no totalmostrando 96
Maternal Immunoglobulin Treatment of Gestational Alloimmune Liver Disease to Prevent Neonatal Liver Failure: A Single Center Case Series.
Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und ImmunhamatologieGestational alloimmune liver disease reconsidered: Advocating for a new nomenclature and enhanced diagnosis accuracy.
World journal of clinical pediatricsIntrauterine high-dose intravenous immunoglobulin therapy during pregnancy for women with a history of pregnancy ending in documented neonatal haemochromatosis (NH001): study protocol.
BMJ openSuccessful IVIG Treatment in Neonatal Hemochromatosis Without Extrahepatic Siderosis: A Case Report.
Reports (MDPI)Novel SKIC3 variants in tricho-hepato-enteric syndrome with hemochromatosis.
Human genome variationThe Effect of Prolonged Antenatal Intravenous Immunoglobulin Treatment in Preventing Gestational Alloimmune Liver Disease-A Case Series with Literature Review.
AJP reportsNeonatal Liver Imaging: Techniques, Role of Imaging, and Indications.
Radiographics : a review publication of the Radiological Society of North America, IncA Rare Afferent Loop Syndrome Case in Adulthood Following Liver Transplantation in Neonatal Hemochromatosis.
Gastro hep advancesSuccessful living-donor liver transplantation for neonatal hemochromatosis due to transient abnormal myelopoiesis with Down syndrome: Case report and review of the literature.
Pediatric blood & cancerUnique presentation of neonatal liver failure: A case report.
World journal of clinical pediatricsClinical characteristics and outcomes of acute liver failure in neonates: a retrospective cohort in China.
European journal of pediatricsGestational alloimmune liver disease with alpha thalassaemia in a neonate.
BMJ case reportsCascade N2 Reduction Process with DBD Plasma Oxidation and Electrocatalytic Reduction for Continuous Ammonia Synthesis.
Environmental science & technology[Association of giant cell hepatitis and autoimmune hemolytic anemia in infancy].
Orvosi hetilapPostinfantile Giant Cell Hepatitis in Native and Allograft Livers: A Multi-Institutional Clinicopathologic Study of 70 Cases.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, IncStriking Cholestatic Giant Cell Hepatitis Resulting in Fulminant Liver Failure After Garcinia Cambogia Use.
International journal of surgical pathologyIdentifying the Aetiology of Acute Liver Failure Is Crucial to Impact Positively on Outcome.
Children (Basel, Switzerland)Neonatal Hemochromatosis: Systematic Review of Prenatal Ultrasound Findings-Is There a Place for MRI in the Diagnostic Process?
Journal of clinical medicinePremature birth associated with a favorable course in gestational alloimmune liver disease (GALD): A case report.
Frontiers in pediatricsA rare case of neonatal hemochromatosis.
Asian journal of surgeryGestational Alloimune Liver Disease-Case Report.
Children (Basel, Switzerland)Diagnostic Value of Serum Gamma Glutamyl Transpeptidase (GGT) for Early Diagnosis of Biliary Atresia.
Mymensingh medical journal : MMJEffectiveness of High-Volume Therapeutic Plasma Exchange for Acute and Acute-on-Chronic Liver Failure in Korean Pediatric Patients.
Pediatric gastroenterology, hepatology & nutritionNeonatal Lupus presenting with neonatal hemochromatosis-like liver disease that responded to steroids: a case report.
BMC pediatricsNeonatal hemochromatosis with εγδβ-thalassemia: a case report and analysis of serum iron regulators.
BMC pediatricsGestational alloimmune liver disease treated with exchange transfusion and intravenous immunoglobulin: A case study.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for HaemapheresisChelation therapy in liver diseases of childhood: Current status and response.
World journal of hepatologyHemolysis in Early Infancy: Still a Cause of Cholestatic Neonatal Giant Cell Hepatitis.
The American journal of surgical pathologyNon-invasive alloimmune risk stratification of long-term liver transplant recipients.
Journal of hepatologyPostinfantile giant cell hepatitis in the setting of autoimmune hepatitis: exclusively a histological pattern or a prognosis predictor?
BMJ case reportsAcute liver failure in newborns.
Turkish archives of pediatricsEfficacy of Intravenous Immunoglobulin/Exchange Transfusion Therapy on Gestational Alloimmune Liver Disease.
Frontiers in pediatricsThe Effect of Prenatal and Postnatal Treatment with Intravenous Immunoglobulin on Severity of Neonatal Hemochromatosis: The Tale of Two Brothers (Case Report).
AJP reportsThe clinical variations and diagnostic challenges of deoxyguanosine kinase deficiency: a descriptive case series.
Journal of pediatric endocrinology & metabolism : JPEMLiving donor liver transplantation for small infants aged less than 6 months: The experience of a single institute.
Journal of pediatric surgeryNeonatal hepatitis B vaccination protects mature adults from occult virus infection.
Hepatology internationalMagnetic resonance imaging of neonatal hemochromatosis.
Pediatric radiologyApplying an Age-specific Definition to Better Characterize Etiologies and Outcomes in Neonatal Acute Liver Failure.
Journal of pediatric gastroenterology and nutritionPIGA Mutations Can Mimic Neonatal Hemochromatosis.
Pediatrics[An updated advance of autoimmune hepatitis in children].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology[A case of idiopathic postinfantile giant cell hepatitis treated with a calcineurin inhibitor].
Deutsche medizinische Wochenschrift (1946)Intravenous Immune Globulin Uses in the Fetus and Neonate: A Review.
Antibodies (Basel, Switzerland)Usefulness of dual gradient-echo MR imaging for the prenatal diagnosis of gestational alloimmune disease.
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and GynaecologyMevalonate Kinase Deficiency as Cause of Periodic Fever in Two Siblings.
Indian pediatricsNeonatal hemochromatosis: A rare cause of liver failure in infancy.
Indian journal of pathology & microbiologyLiver Failure Among Young Saudi Infants: Etiology, Clinical Presentation, and Outcome.
Journal of pediatric gastroenterology and nutritionHepatitis B virus seroprevalence among HIV-infected patients receiving combination antiretroviral therapy three decades after universal neonatal hepatitis B immunization program in Taiwan.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhiThe fragmented red cell count can support the diagnosis of a microangiopathic neonatal condition.
Journal of perinatology : official journal of the California Perinatal AssociationLetter: decreased neonatal hepatitis B virus (HBV) viremia by maternal tenofovir treatment predicts reduced chronic HBV infection in children born to highly viremic mothers.
Alimentary pharmacology & therapeuticsManaging the Unusual Causes of Fetal Anemia.
Fetal diagnosis and therapyHemophagocytic lymphohistiocytosis mimicking neonatal hemochromatosis.
Pediatric hematology and oncologySub-acute neonatal hemochromatosis in an infant with hypoplastic left heart syndrome on ventricular assist device awaiting transplantation.
Pediatric transplantationNeonatal hemochromatosis associated with rupture of esophageal varices.
Pediatrics international : official journal of the Japan Pediatric SocietyNeonatal hemochromatosis in a newborn with Down syndrome.
Fetal and pediatric pathologyCLL associated giant cell hepatitis.
Leukemia researchManagement of giant cell hepatitis associated with chronic lymphocytic leukemia - a case series and review of the literature.
Cancer biology & therapyPediatric liver transplantation for neonatal-onset Niemann-Pick disease type C: Japanese multicenter experience.
Pediatric transplantationB-cell depletion induces prolonged remission in patients with giant cell hepatitis and autoimmune hemolytic anemia.
Clinics and research in hepatology and gastroenterologyA case of Niemann-Pick disease type C with neonatal liver failure initially diagnosed as neonatal hemochromatosis.
Brain & developmentGestational Alloimmune Liver Disease: A Case Study.
Neonatal network : NNPrenatal imaging features suggestive of liver gestational allo immune disease.
Journal of gynecology obstetrics and human reproductionHeterogeneous Presentation of Neonatal Hemochromatosis in Dichorionic Twins.
AJP reportsHemochromatosis associated with cholelithiasis as a cause of hydrops fetalis and stillbirth: Prenatal diagnosis.
Journal of clinical ultrasound : JCUPrognostic parameters of pediatric acute liver failure and the role of plasma exchange.
Pediatrics and neonatology[Neonatal haemochromatosis: 10 years into a paradigm shift].
Anales de pediatriaBiochemical profile in an infant with neonatal hemochromatosis shows evidence of impairment of mitochondrial long-chain fatty acid oxidation.
Clinical and molecular hepatologyBroadening the spectrum of neonatal hemochromatosis.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal ObstetriciansThe Japanese experience and pharmacokinetics of antenatal maternal high-dose immunoglobulin treatment as a prophylaxis for neonatal hemochromatosis in siblings.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal ObstetriciansLiver Failure and Conjugated Hyperbilirubinemia in a Preterm Neonate: Role of Early IVIG and Exchange Transfusion.
AJP reportsThe Effects of Gestational Alloimmune Liver Disease on Fetal and Infant Morbidity and Mortality.
The Journal of pediatricsDisparate clinical findings in monochorionic twins with neonatal hemochromatosis.
Pediatrics international : official journal of the Japan Pediatric SocietyMagnetic Resonance Imaging Findings in Neonatal Hemochromatosis.
Journal of pediatric gastroenterology and nutritionRescue case of low birth weight infant with acute hepatic failure.
World journal of gastroenterologyAntenatal Treatment with Intravenous Immunoglobulin to Prevent Gestational Alloimmune Liver Disease: Comparative Effectiveness of 14-Week versus 18-Week Initiation.
Fetal diagnosis and therapyPresenting Features and Prognosis of Ischemic and Nonischemic Neonatal Liver Failure.
Journal of pediatric gastroenterology and nutrition[Liver failure in neonatal children is a diagnostic challenge].
Ugeskrift for laegerNeonatal acute liver failure: a diagnosis challenge.
Archivos argentinos de pediatriaNeonatal Liver Failure and Congenital Cirrhosis due to Gestational Alloimmune Liver Disease: A Case Report and Literature Review.
Case reports in pediatricsNeonatal Hemochromatosis: Blitz Diagnosis Results in Favorable Outcome.
The Journal of pediatricsRelevance of C5b9 immunostaining in the diagnosis of neonatal hemochromatosis.
Pediatric researchAn immunohistochemical study of placental syncytiotrophoblasts in neonatal hemochromatosis.
Placenta[Gestational alloimmune liver disease: a case report].
Archivos argentinos de pediatriaAntenatal immunoglobulin for prevention of neonatal hemochromatosis.
Pediatrics international : official journal of the Japan Pediatric SocietyGestational Alloimmune Liver Disease: A Devastating Condition Preventable With Maternal Intravenous Immunoglobulin.
Obstetrics and gynecologyFetal Magnetic Resonance Imaging Detection of Liver Iron Deposition in Neonatal Hemochromatosis During Prenatal Therapy.
Journal of pediatric gastroenterology and nutritionLiving Related Liver Transplantation in an Infant with Neonatal Hemochromatosis.
Pediatric gastroenterology, hepatology & nutritionLiver Failure, Hepatic Siderosis, and Membrane Attack Complexes: Neonatal Hemochromatosis and/or Galactosemia?: RETRACTED.
Journal of pediatric gastroenterology and nutritionIron Overload Coordinately Promotes Ferritin Expression and Fat Accumulation in Caenorhabditis elegans.
GeneticsLiver Failure in Early Infancy: Aetiology, Presentation, and Outcome.
Journal of pediatric gastroenterology and nutritionCase 1: Oral Mucosal Bleeding in a 2-day-old Boy.
Pediatrics in reviewNeonatal hemochromatosis in monochorionic twins.
Journal of neonatal-perinatal medicineSuccessful treatment of hemochromatosis with renal tubular dysgenesis in a preterm infant.
Clinical case reports[Neonatal hemochromatosis: Another entity that is no longer orphan. Advances in the diagnosis and management of the main cause of neonatal acute liver failure].
Anales de pediatria (Barcelona, Spain : 2003)Gestational autoimmune disease in newborns with an indeterminate cause of death following a complete autopsy.
Journal of neonatal-perinatal medicineReview of fetal and neonatal immune cytopenias.
Clinical advances in hematology & oncology : H&OLiver transplantation for neonatal hemochromatosis: analysis of the UNOS database.
Pediatric transplantationAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Gestational alloimmune liver disease reconsidered: Advocating for a new nomenclature and enhanced diagnosis accuracy.
- Intrauterine high-dose intravenous immunoglobulin therapy during pregnancy for women with a history of pregnancy ending in documented neonatal haemochromatosis (NH001): study protocol.
- Correction: Neonatal Lupus presenting with neonatal hemochromatosis-like liver disease that responded to steroids: a case report.
- Maternal Immunoglobulin Treatment of Gestational Alloimmune Liver Disease to Prevent Neonatal Liver Failure: A Single Center Case Series.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie· 2025· PMID 41368233mais citado
- Successful IVIG Treatment in Neonatal Hemochromatosis Without Extrahepatic Siderosis: A Case Report.
- Severe Congenital Systemic Juvenile Xanthogranuloma With Neonatal Acute Liver Failure, Neonatal Hemochromatosis and Placental Infiltration.
- A Non-Fetal Chronic Residual Inflammatory Liver Phenotype After Transient Abnormal Myelopoiesis in Down Syndrome.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:446(Orphanet)
- OMIM OMIM:231100(OMIM)
- MONDO:0009275(MONDO)
- Sobrecarga de Ferro — Hemocromatose Hereditaria(PCDT · Ministério da Saúde)
- GARD:7172(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Q1627324(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
