Infestação parasitária do sistema linfático humano por wuchereria bancrofti ou brugia malayi. Também é chamada de filariose linfática.
Introdução
O que você precisa saber de cara
Infestação parasitária do sistema linfático humano por wuchereria bancrofti ou brugia malayi. Também é chamada de filariose linfática.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 13 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 33 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Nenhum gene associado encontrado
Os dados genéticos desta condição ainda estão sendo catalogados.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Filariose linfática
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Outros ensaios clínicos
94 ensaios clínicos encontrados, 4 ativos.
Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 1.800
Emergence of a novel zoonotic brugian filarial infection during post-validation surveillance for lymphatic filariasis in Sri Lanka.
Lymphatic filariasis (LF) affects approximately 120 million people globally and is caused by Wuchereria bancrofti, Brugia malayi and Brugia timori. Sri Lanka was historically endemic for both bancroftian and brugian filariasis, with B. malayi presumed eliminated by the late 1960s. The country achieved validation of LF elimination as a public health problem in 2016. However, sporadic Brugia infections have been detected in microfilaria surveys from the mid-2000s onwards; the sub-periodic periodicity of which is suggestive of a zoonotic origin and warrants further research. Night blood survey (NBS) surveillance was conducted by the Anti-Filariasis Campaign, Ministry of Health, Sri Lanka, from 2019 to 2023. Brugia-positive human samples and archived canine samples were analysed using a next-generation sequencing metabarcoding platform targeting mitochondrial and nuclear loci. Bayesian and neighbour-joining phylogenetic analyses and minimum-spanning network approaches were used to characterise lineage relationships. Among 1,855,165 individuals screened, 52 were identified with Brugia-like microfilariae. Metabarcoding generated 1.2 million high-quality reads with both mitochondrial cox1 and ribosomal DNA markers confirming a single Brugia lineage circulating in humans, mainly in children. Sequences of the c ox1 gene showed 99.4-100 percent nucleotide identity to the Brugia Sri Lanka (SL) genotype previously detected in dogs in Sri Lanka and Tamil Nadu (India). rDNA sequences showed low similarity to B. malayi or Brugia pahangi, indicating that the parasite represents a distinct Brugia taxon lacking a reference rDNA sequence. The findings provide evidence that human brugian filariasis in Sri Lanka is caused by a previously unrecognised zoonotic Brugia species maintained in dogs. This has important clinical and public health implications given that human infections have occurred in children despite LF being declared eliminated as a public health problem. Crucially, the incorrect classification of circulating filarioid species may lead to inappropriate clinical and programmatic responses. For example, the newly identified canine reservoir of this Brugia genotype means that human-only mass drug administration might not be sufficient to interrupt this species' transmission. These results underscore the need for integrated One Health surveillance to prevent re-establishment of LF and safeguard regional elimination goals. No specific funding was received for the present study. This study was supported by a consulting funding (PRJ_002971).
Cross-sectional study to assess filarial infection among the never treated individuals in selected districts in India: a study protocol.
With the global lymphatic filariasis (LF) elimination goal set to 2030, it is necessary to address challenges hindering the last-mile efforts. Never treated individuals are those who self-report that they have never taken the drugs for LF during any mass drug administration (MDA) rounds. Hence, it is necessary to identify these individuals and assess if they can be potential reservoirs of infection and understand the reasons for non-compliance. This mixed method study, proposed for a period of 2 years, will assess the filarial infection status of never treated individuals from four LF-endemic districts in India. A multi-stage cluster sampling design will be followed to select the health subcentres from one highly endemic block in each of the selected districts. A random sample of 2535 never treated individuals from each block will be assessed for filarial infection by a cross-sectional blood survey. Qualitative surveys, including in-depth interviews and focus group discussions, will be conducted to elicit the reasons for their non-compliance. The prevalence of filarial infection will be summarised as frequencies and percentages. Univariate and multivariate logistic regression analysis will be performed to find the factors associated with filarial infection. Exploring the various reasons, such as sociocultural, behavioural and programmatic drivers of non-participation, will enable the programme to design tailored communication and community engagement strategies to bring them under the umbrella of MDA and thereby support the ongoing LF elimination efforts. This study has been approved by the institutional ethics committee (IHEC 07-0824/N/F, dated 25 September 2024). After completion of the study, a workshop will be held with all stakeholders to disseminate the study findings.
Altitudinal and household breeding patterns of the medically important mosquitoes Aedes aegypti, Aedes albopictus and Culex quinquefasciatus in Nepal.
Medically relevant mosquitoes have established populations across Nepal, adapting to diverse environmental conditions and altitudes. In addition to arbovirus vectors, the presence of Culex quinquefasciatus, a primary vector of lymphatic filariasis, underscores the need for comprehensive mosquito surveillance. This study investigated the presence, abundance, container preferences, and altitudinal distribution of Aedes aegypti, Aedes albopictus, and Cx. quinquefasciatus across selected districts in Nepal. We also examined the co-occurrence of Aedes species and their association with container type and location. An entomological survey was conducted along an altitudinal transect from 140 meters above sea level (m asl) (Chitwan) to 2340 m asl (Dolakha). Immatures were collected from 1,157 water-holding containers across 636 households using dipper and dropper techniques, while adults were captured using BG-Sentinel traps. Immatures were reared to adulthood for identification, while non-reared specimens were identified via microscopic slides. A total of 1,323 immature and 158 adult mosquitoes were recorded. Among immatures, Ae. albopictus (47.6%) was the most abundant, followed by Ae. aegypti (43.4%). Adults were predominantly Cx. quinquefasciatus (82.9%). Plastic bottles and drums were the most common larval habitats. Aedes species were found across the study transect, from 140 to 2066 m asl. The altitude did not have a statistically significant effect on the number of collected mosquitoes (p = 0.563). These findings highlight the widespread presence of Aedes and Culex species across different altitudes and breeding habitats. The predominance and co-occurrence of dengue vectors and Cx. quinquefasciatus in nearby households underscore the need for integrated vector surveillance and control strategies in Nepal.
Noise and neglect: Social-media signals expose attention gaps for dengue, chikungunya, lymphatic filariasis and kala-azar in India's vector-borne NTDs.
Neglected tropical and vector-borne diseases, including dengue, chikungunya, lymphatic filariasis, and kala-azar, pose substantial public health burdens in India. Despite WHO recommendations for enhanced disease surveillance and targeted communication strategies, little is known about public perceptions and discussions of these diseases across digital platforms. Understanding these perceptions can guide evidence-based policy making and public health messaging. We conducted an in silico analysis of publicly accessible social and news media data related to dengue, chikungunya, filariasis, and kala-azar in India from January 2019 to December 2023. YouTube comments and Google News headlines were systematically retrieved, pre-processed, and analysed through sentiment analysis (VADER lexicon) and Latent Dirichlet Allocation (LDA) topic modelling. Facebook and Twitter data were not included due to Application programming interface (API) restrictions and their current subscription-based models, limiting free access even for research purposes. We visualized disease-specific digital attention in comparison to epidemiological burden and created chord, Sankey, and network diagrams to elucidate thematic and sentiment-based interactions. Across keyword-matched items (n = 330), dengue accounted for 173 (~52%) and also had the highest mean annual reported burden (163,679 cases/year; 2019-2023). Lymphatic filariasis showed disproportionately high attention (106 items/mentions vs 3,060 reported cases/year), while kala-azar had minimal visibility (5 items; none on YouTube). Sentiment was overall neutral-to-positive, with Google News more neutral and YouTube more positive. Topics emphasized outbreak alerts, public-health campaigns, and prevention/treatment, with recurring vaccine/innovation themes. Our study presents a novel approach combining digital surveillance, sentiment analysis, and topic modelling to provide insights into public perceptions of NTDs in India. The observed mismatch between epidemiological burden and online attention underscores the need for strategic public health messaging, aligning with WHO recommendations for community engagement and tailored disease-awareness campaigns. This research provides a valuable tool for policymakers to enhance the effectiveness of communication strategies and improve targeted intervention planning for neglected tropical diseases in India.
The impact of the termination of Lymphatic Filariasis mass drug administration on Soil-transmitted Helminth prevalence in school children in Malawi.
Soil-transmitted helminths (STH) have been passively targeted through the implementation of mass drug administration (MDA), with the drugs ivermectin and albendazole, against the parasitic disease, lymphatic filariasis (LF). In Malawi, LF MDA was administered to communities between 2008 and 2014. The aim of this analysis was to estimate the impact of LF MDA and its termination on STH prevalence in school aged children (SAC). School survey data of STH prevalence in Malawi were obtained through the ESPEN website. The surveys spanned the periods before (1998-2004), during (2012-2014) and after LF MDA (2015-2019). Bayesian mixed-effects models were fitted to estimate the impact of LF MDA termination, and other STH risk factors, on the odds of infection, as well as generate predictions of nationwide STH prevalence during and after LF MDA. SAC after the termination of LF MDA had 1.8 times greater odds of A. lumbricoides infection compared to SAC during the implementation of LF MDA (95% credible interval (CI): 1.03 - 3.35), despite ongoing STH preventive chemotherapy (PC) targeting SAC. Predictions indicate majority of districts increased in their probability of exceeding 2% A. lumbricoides prevalence in SAC after the termination of LF MDA, with Chitipa, Mulanje and Nsanje districts estimated to have > 80% probability of exceeding 2% prevalence. An overall resurgence in A. lumbricoides infections after LF MDA was estimated in SAC, despite ongoing annual STH PC. This suggests STH PC could not sustain the prevalence levels achieved in SAC under community-wide LF MDA. The potential role of drug resistance in this resurgence calls for urgent investigation. Understanding how this resurgence corresponds to prevalence of moderate and heavy infections should be a priority for future research.
Publicações recentes
Hotspot-based integrated serosurveillance of neglected tropical diseases, malaria, and vaccine-preventable diseases in urban Guyana.
Public-Private Partnership offers a strategic opportunity for Lymphatic Filariasis Elimination in India by 2030.
Tetracycline Resistance Pattern Among Lymphatic Filariasis-Hyperendemic Communities in Southern Ghana: A Mixed-Method Approach.
The influence of human population movement on mass drug administration for neglected tropical diseases: a scoping review.
Human Filariasis in Africa (2000-2025): Changing epidemiology, uneven diagnostic progress, and persistent neglect.
📚 EuropePMC1.783 artigos no totalmostrando 197
Emergence of a novel zoonotic brugian filarial infection during post-validation surveillance for lymphatic filariasis in Sri Lanka.
The Lancet regional health. Southeast AsiaLived experiences, stigma and impacts of lymphatic filariasis: a scoping review.
International healthCross-sectional study to assess filarial infection among the never treated individuals in selected districts in India: a study protocol.
BMJ openAltitudinal and household breeding patterns of the medically important mosquitoes Aedes aegypti, Aedes albopictus and Culex quinquefasciatus in Nepal.
PloS oneNoise and neglect: Social-media signals expose attention gaps for dengue, chikungunya, lymphatic filariasis and kala-azar in India's vector-borne NTDs.
PLoS neglected tropical diseasesCircumferential Negative Pressure Lymphedema Therapy: A Novel Rapid Perioperative Decongestion Strategy for Advanced Stage III-IV Lymphedema.
CureusHigh prevalence of bancroftian filariasis and comorbidities in the eastern coalfield regions of West Bengal, India following COVID-19 disruption.
Scientific reportsBiochemical, molecular, and in silico insights into the effects of cyphenothrin on Culex quinquefasciatus mosquitoes.
Parasites & vectorsCost-Effectiveness of Triple Versus Dual-Drug Therapy for Elimination of Lymphatic Filariasis in India.
Value in health regional issuesPost elimination of lymphatic filariasis: a situation analysis of brugian filariasis and vector potentialities within the filarial transmission belt in Sri Lanka.
Parasites & vectorsFrom neglect to empowerment: impact of vocational rehabilitation on quality of life among disabled filarial lymphoedema patients in a brugian-endemic region of South India-a mixed methods evaluation.
Transactions of the Royal Society of Tropical Medicine and HygieneSociodemographic determinants of lymphatic filariasis knowledge among refugees in Cameroon.
Discover public healthDesign of an implementation research study for a digital omnichannel community engagement and risk communication intervention for the prevention and control of vector-borne diseases in India: the OMNIVEC-India study protocol.
Frontiers in public healthHigh-Dose Rifampicin Plus Albendazole Rapidly Clears Lymphatic Filariasis Circulating Filarial Antigen in a Randomised Clinical Trial: A Promising Step Toward Short-Course Macrofilaricidal Therapy.
Pathogens (Basel, Switzerland)Enablers of Post-Validation Surveillance for Lymphatic Filariasis in the Pacific Islands: A Nominal Group Technique and Expert Elicitation.
Tropical medicine and infectious diseaseIntegrated Approaches to Surveillance of Lymphatic Filariasis and Other Infectious Diseases in the Pacific Islands.
Tropical medicine and infectious diseaseThe impact of the termination of Lymphatic Filariasis mass drug administration on Soil-transmitted Helminth prevalence in school children in Malawi.
PLoS neglected tropical diseasesMeasuring Progress of 2030 Skin-Related Neglected Tropical Diseases Sustainable Development Goals.
JAMA dermatologyDeep phenotypic profiling uncovers cryptic effects of antifilarial drugs.
bioRxiv : the preprint server for biologyPhytol from Sphaeranthus indicus: A Natural Insecticide Against Aedes aegypti and Culex quinquefasciatus.
Acta parasitologicaVulval Lymphedema: An Under-Recognized Clinical Manifestation of Lymphatic Filariasis.
The American journal of tropical medicine and hygieneEstablishing a filarial clinical research platform in a resource-limited setting: Lessons and experiences from Tanzania.
PLoS neglected tropical diseasesDefining onchocerciasis transmission zones: Integrating operational insights with genomic and ecological advances.
International healthReview of selected mosquito-borne diseases: arboviruses (dengue, chikungunya, Zika, West Nile, Japanese encephalitis, yellow fever) and parasitic diseases (malaria, lymphatic Filariasis).
Frontiers in public healthThe Death to Onchocerciasis and Lymphatic Filariasis (DOLF) project: Accomplishments and ongoing research.
PLoS neglected tropical diseasesCross-sectional epidemiological assessment of lymphatic filariasis situation in areas under post-mass drug administration surveillance and the associated risk of transmission in the context of migrants in India: a study protocol.
BMJ openGlobal Lymphatic Filariasis Post-Validation Surveillance Activities in 2025: A Scoping Review.
Tropical medicine and infectious diseaseBarriers and Facilitators to Implementing Post-Validation Surveillance of Lymphatic Filariasis in Pacific Island Countries and Territories: A Conceptual Framework Developed from Qualitative Data.
Tropical medicine and infectious diseaseFinding the Gaps: Integrated Serosurveillance and Spatial Clustering of Vaccine Preventable Diseases in Samoa, 2018-2019.
Tropical medicine and infectious diseaseSpatial Risk Factors of Vector-Borne Diseases in Pacific Island Countries and Territories: A Scoping Review.
Tropical medicine and infectious diseaseVitamin A and D levels in patients with filarial lymphedema and healthy volunteers in Puducherry, India.
Frontiers in nutritionTransmission status of lymphatic filariasis in hotspots of filarial infection, persistent districts of nepal during post-MDA surveillance.
PloS onePatient perspectives and barriers to effective home-based care in lymphatic filariasis: A mixed methods study from Puducherry, India.
PLoS neglected tropical diseasesExploring the landscape of lymphatic filariasis research in India: A scientometric analysis of two decades from 2000 to 2024.
PLoS neglected tropical diseasesDo we have a match? Calculating the potential for integrating neglected tropical disease control programmes for sustainable public health policy.
Acta tropicaNeglected by Design: Occupational Parasitic Infections in India's Lower Castes.
The Yale journal of biology and medicineLiving with Filariasis: Unseen Struggles of a Neglected Disease.
The Yale journal of biology and medicineMeta-analysis of the prevalence of lymphatic filariasis infection in mosquito vectors.
Frontiers in cellular and infection microbiologyNeglected tropical diseases elimination in Africa: lessons from regional control programmes.
Tropical medicine and healthAssessment of mosquito species communities biting humans and their livestock in the forest hills of Karen state, Myanmar: a cross-sectional survey in six villages.
Parasites & vectorsLymphatic Filariasis in India: A Historical and Contemporary Overview.
Journal of vector borne diseasesFamily quality of life and associated factors among people with leprosy or podoconiosis/lymphatic filariasis with visible disabilities and their family members in Ethiopia: a baseline study for a randomized controlled trial.
Transactions of the Royal Society of Tropical Medicine and HygieneReversal of filarial serpin Wb123-urokinase plasminogen activator receptor mediated alternative macrophage activation by monoclonal antibody.
PLoS neglected tropical diseasesLarvicidal and macrofilaricidal efficacy of closantel and morantel against mosquito larvae and Setaria digitata nematodes.
Experimental parasitologyRevisiting the epidemiology of schistosomiasis and soil-transmitted helminthiasis in Chad: insights for improved interventions.
International healthThe role of molecular xenomonitoring for assessing the impact of Ivermectin, Diethylcarbamazine Citrate and Albendazole triple-drug treatment against lymphatic filariasis: A cross-sectional study in the Kenyan coastal region.
PLOS global public healthDiethylcarbamazine elicits calcium signals by activation of Brugia malayi TRP-2b channels heterologously expressed in HEK293 cells.
Scientific reportsWbm0152, an outer membrane lipoprotein of the Wolbachia endosymbiont of Brugia malayi, inhibits yeast ESCRT complex activity.
PLoS pathogensTwo decades of filariasis in India: Insights into prevalence, diagnostic challenges, and strategies for elimination by 2027.
IJID regionsCoverage evaluation of mass drug administration for lymphatic filariasis in four endemic districts of Jharkhand, India.
Journal of health, population, and nutritionBayesian hierarchical spatial ecological model assessing the nexus of vegetation index, insecticide-treated bed-nets and livestock cattle density on lymphatic filariasis transmission.
BMC public healthRisk factors of lymphatic filariasis in Asia: a systematic review.
BMC infectious diseasesSemi-annual and annual mass drug administration of diethylcarbamazine and albendazole are equally effective regimens for eliminating lymphatic filariasis in Papua New Guinea.
PLoS neglected tropical diseasesElephantiasis and verrucous lesions in an Ethiopian man living in Italy.
Journal of infection and public healthCommunity engagement in mass drug administration participatory interventions: A scoping review.
PLoS neglected tropical diseasesMolecular Characterisation of Fungi Populations in the Chronic Wounds of Filarial Lymphedema Patients in Southern Ghana: A Cross-Sectional Study.
Health science reportsDetermining Etiology of Elephantiasis and Associated Factors in Hawella Tula, Sidama Region, Ethiopia.
Research and reports in tropical medicineA framework for guiding integrated disease control measures through multipathogen surveillance.
medRxiv : the preprint server for health sciencesField trial finds promising evidence on Spinosad: a bio-larvicide for mosquito control in urban settings in Bengaluru, India.
Malaria journalAchieving elimination of soil-transmitted helminthiasis as a public health problem in Mali.
BMJ global healthStructure-based virtual screening of β-tubulin and thioredoxin reductase in Brugia malayi: a step toward novel anti-filarial agents.
In silico pharmacologyLymphatic filariasis remained silent until presentation with huge abdominal mass mimicking malignancy: a case report.
ASM case reportsBlood parasitic diseases in India: Current landscape, challenges, and the road ahead.
Tropical parasitologyImplementation of basic package of care improved socio-economic conditions of lymphedema patients in rural Mali after two years follow-up.
PLOS global public healthDouble Trouble in the Thyroid: Coexistence of Hurthle Cell Neoplasm and Microfilarial Infestation.
Discoveries (Craiova, Romania)Anopheles barbirostris in Indonesia: A more complex metapopulation than expected.
PloS oneBrugia malayi miRNAs and potential targets within the feline host (Felis catus).
Current research in parasitology & vector-borne diseasesIn silico screening of flavonoid-based inhibitors targeting UDP-galactopyranose mutase of Brugia malayi for lymphatic filariasis drug design.
Computers in biology and medicineClinical Manifestations of Lymphatic Filariasis and Practice of Vector Control Measures after 15 Years of Mass Drug Administration: A Rapid Epidemiological Study from Odisha.
Indian journal of community medicine : official publication of Indian Association of Preventive & Social MedicineCOMET-LF: a compartmental model of dynamics of infection, disease, and elimination strategies for lymphatic filariasis.
BMC infectious diseasesPatient journeys for neglected tropical diseases in rural sub-Saharan Africa: a scoping review.
Infectious diseases of povertyPrevalence of Malaria Among Individuals Living With Lymphedema in Kamwenge District, Western Uganda.
CureusInvestigating the resurgence of malaria in Rwanda: factors contributing to rising cases amidst near-eradication success and strategies for sustained control.
Annals of medicine and surgery (2012)Identification of key pharmacophore feature motifs from the potent leads of the major antioxidant enzymes of W. bancrofti and in vitro validation studies of the key enzyme WbPrx6 using the model organism S. digitata.
Computers in biology and medicineAcute Brugian filariasis in a German tourist after short-term travel to Sri Lanka, 2025.
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletinMolecular xenomonitoring highlights post-MDA surveillance priorities for sustained Wuchereria bancrofti elimination in Burkina Faso.
Tropical medicine and healthComparison of Platelet Functions, Plasma Proteins and Lipids in Filarial and Non-Filarial Edema Patients.
Parasite immunologyZoonotic brugian filariasis past and present trends in malaysia: A systematic review and proportionate meta-analysis.
Scientific reportsMoxidectin combination therapies for lymphatic filariasis-36-month follow-up.
The Lancet. Infectious diseasesA Triple Regimen as an Alternative Treatment for Lymphatic Filariasis in a Non-endemic Area in Indonesia: A Case Report.
CureusStructural Barriers and the Future of AI in Global Health: Lessons From Eradicable Diseases.
CureusPiloting lymphoedema management for lymphatic filariasis: experiences and perceptions of patients and stakeholders from Kwale county, coastal Kenya.
BMC public healthBrugia malayi and other filarial parasite species in animals in areas endemic for lymphatic filariasis in Belitung District, Indonesia.
PLoS neglected tropical diseasesGlobal Epidemiology of Vector-Borne Parasitic Diseases: Burden, Trends, Disparities, and Forecasts (1990-2036).
Pathogens (Basel, Switzerland)No evidence of Wuchereria bancrofti infection in Anopheles species after 10 years without mass drug administration: a molecular xenomonitoring study in Hauts-Bassins, Burkina Faso.
Tropical medicine and healthFrom Burden to Breakthrough: The Impact of Mass Drug Campaigns on Microfilaria Trends Based on Evidence From Sentinel Site Surveillance in Rural Nagpur, Maharashtra, India, Over Two Decades.
CureusActive constituent nonacosane from Sphaeranthus indicus (Asterales: Asteraceae) leaves as a potent larvicidal agent against Aedes aegypti (Diptera: Culicidae) and Culex quinquefasciatus (Diptera: Culicidae).
Parasitology internationalDetection of potential transmission foci of lymphatic filariasis using molecular xenomonitoring in Huahine, French Polynesia.
PLoS neglected tropical diseasesAssessing the need to implement mass drug administration against Wuchereria bancrofti infection using both human serology and xenomonitoring in the urban conurbation of Monrovia, Liberia.
PLoS neglected tropical diseasesA multicenter evaluation of the Filariasis IgG4 Rapid Test for detection of lymphatic filariasis.
Acta tropica"String sign"- acute lymphangitis in the forearm following triple drug therapy for bancroftian filarial infection.
Journal of vector borne diseasesPositive allosteric modulation of emodepside sensitive Brugia malayi SLO-1F and Onchocerca volvulus SLO-1A potassium channels by GoSlo-SR-5-69.
PLoS pathogensHarnessing the potential of phytochemicals to design anti-filarial molecules targeting the MurE enzyme of Brugia malayi: a hierarchical virtual screening and molecular dynamics simulation study.
SAR and QSAR in environmental researchImpact of diabetes mellitus on adenolymphangitis episodes in patients with filarial lymphedema-Towards an integrated care approach.
PLoS neglected tropical diseasesUnlocking the blueprint to eliminating neglected tropical diseases: A review of efforts in 50 countries that have eliminated at least 1 NTD.
PLoS neglected tropical diseasesLarvicidal mechanism of the rare sesquiterpene ishwarol B from Piper alatipetiolatum (Piperaceae) against Aedes aegypti, Anopheles darlingi, and Culex quinquefasciatus (Culicidae): oxidative damage, defense enzyme modulation, and acetylcholinesterase inhibition.
Chemico-biological interactionsThe Impact of Displacement on Skin-Related Neglected Tropical Diseases in Sudan.
Clinical and experimental dermatologyThe Burden of Neglected Tropical Diseases in Rwanda: A Scoping Review.
Health science reportsClinical profile and Mass Drug Administration coverage in patients with lymphatic filariasis: A descriptive study.
Journal of family medicine and primary careA virtual screening strategy to repurpose antifolate compounds as W.bancrofti DHFR inhibitors.
Bioorganic & medicinal chemistry lettersSocial and healthcare-seeking experiences of people affected with lymphedema in Bangladesh.
PLoS neglected tropical diseasesLymphoedema - Filariasis or soft tissue sarcoma? A case report.
Malaysian family physician : the official journal of the Academy of Family Physicians of MalaysiaConfirmatory mapping for lymphatic filariasis a decade after baseline endemicity assessment in highly urbanized settings of Lagos, Nigeria.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious DiseasesEffects of doxycycline on prepatent and patent infections of Brugia pahangi in dogs and observations on the growth and survival of L3 in jirds and dogs.
Veterinary parasitologyLarvicidal and Pupicidal Activity of Neonicotinoid Insecticide Imidacloprid against Southern House Mosquito, Culex Quinquefasciatus (Say) (Diptera: Culicidae).
Acta parasitologicaDetection of Filarial IgG and IgM Antibodies Among Individuals With Lymphedema in the Kamwenge District, Western Uganda.
CureusPublic health surveillance of tropical diseases in Madagascar: a scoping review of population burden, intervention strategies, and health system responses.
BMC public healthCurrent Gaps in Survey Design and Analysis for Molecular Xenomonitoring of Vector-Borne Neglected Tropical Diseases: A Systematic Review.
Tropical medicine & international health : TM & IHAccess and Awareness of Morbidity Management and Disability Prevention for Lower Limb Lymphatic Filariasis in Post-Mass Drug Administration Districts in Southern India.
The American journal of tropical medicine and hygienePreliminary evaluation of inactivated antigens as diagnostic controls in molecular detection of vector-borne diseases in low-resource settings.
Journal of vector borne diseasesFeasibility of interrupting the transmission of soil-transmitted helminths: the DeWorm3 community cluster-randomised controlled trial in Benin, India, and Malawi.
Lancet (London, England)Epidemiological monitoring survey to assess the impact of mass drug administration with triple-drug regimen in lymphatic filariasis elimination programme in an endemic district in Southern India.
PLoS neglected tropical diseasesThe changing neglected tropical disease landscape in Africa: implications for policy, practice, and strengthening health systems.
Health affairs scholarInfluence of the physicochemical characteristics of mosquito breeding sites in domestic environments on the distributions of Anopheles, Aedes and Culex mosquitoes in Benin.
Tropical medicine and healthField evaluation of Standard Q Filariasis Antigen Test for Lymphatic Filariasis (LF) during a pre-transmission assessment survey in Sierra Leone, 2022.
PLoS neglected tropical diseasesSequence Localization of SeGPx in S. digitata Genome Contigs and Determination of its Presence in the Whole Worm Extract.
Acta parasitologicaAverting collapse: Reimagining the NTDs ecosystem through G20 health diplomacy and science innovation.
Microbes and infectionAcceptability of mass drug administration for lymphatic filariasis in Baglung Municipality of Nepal: A mixed-method study.
PLOS global public healthExploring the Antibacterial, Antioxidant and Larvicidal Effects against Culex quinquefasciatus of Nigella sativa Seeds and its Silver Nanoparticles.
Acta parasitologicaIntegrating geospatial tools is crucial for enhancing control strategies against human lymphatic filarial infections in Ghana: A comprehensive review.
Parasite epidemiology and controlTesticular Lymphatic Filariasis.
Radiographics : a review publication of the Radiological Society of North America, IncHost environment shapes filarial parasite fitness and Wolbachia endosymbionts dynamics.
PLoS pathogensReactive case detection can improve the efficiency of lymphatic filariasis surveillance compared to random sampling, Samoa 2023.
PLoS neglected tropical diseasesGlobal insights can accelerate India's journey towards the elimination of lymphatic filariasis as a public health problem.
BMJ global healthEvaluating the effectiveness of mass drug administration on lymphatic filariasis transmission and assessment of post-mass drug administration surveillance in Nigeria's Federal Capital Territory.
Infectious diseases of povertyHealthcare Undergraduates' Perception and Practice Regarding Lymphatic Filariasis and Mass Drug Administration in a Tertiary Care Facility in Eastern India.
CureusA mixed-method study to improve outcome of mass drug administration in two TAS failed districts of Uttar Pradesh, India.
PLoS neglected tropical diseasesPrevalence and patterns of multiple long-term conditions among lymphatic filariasis patients in Odisha, India: a community-based cross-sectional study.
BMC public healthCoverage and determinants of Mass Drug Administration against lymphatic filariasis in Southeast Asian regional countries during the end-game strategy: A systematic review and meta-analysis.
Journal of vector borne diseasesComparative analysis of skin microbiome of patients with filarial lymphedema and healthy individuals.
PloS oneAssessment of the effectiveness of public art in improving knowledge, attitude, practices and mitigation of stigmatization regarding neglected tropical diseases in South Eastern, Nigeria.
PLoS neglected tropical diseasesA Next-Generation Human Lymphatic Filariasis Vaccine Candidate, rBmHAXT, for Clinical Development.
Research squareStructure-based designing of anti-filarial molecules targeting the key antioxidant enzyme glutathione peroxidase (GPx) of Wuchereria bancrofti: An integrated in silico and in vitro approach.
Computers in biology and medicineExamining the overlap in lymphatic filariasis prevalence and malaria insecticide-treated net access-use in endemic Africa.
PLoS neglected tropical diseasesEvaluation of sampling strategies for assessing lymphatic filariasis endemic status of a non-MDA district in South India.
PLoS neglected tropical diseasesOverexpression of cytochrome P450 and esterase genes in pyrethroid-resistant wild Culex quinquefasciatus populations from sub-Himalayan West Bengal, India.
Parasitology researchUncertainty quantification in cost-effectiveness analysis for stochastic-based infectious disease models: Insights from surveillance on lymphatic filariasis.
Journal of theoretical biologyLymphatic filariasis: from neglected tropical disease to national priority.
The Lancet. Infectious diseasesCommunity views on mass drug administration for soil-transmitted helminths: a qualitative evidence synthesis.
The Cochrane database of systematic reviewsThe Feasibility of Using Telehealth for Training Health Care Workers and Persons with Disability on Integrated Rehabilitation and Prevention of Impairments and Disabilities of Leprosy, Lymphatic Filariasis, Diabetes, Pressure Ulcers, and Other Chronic Wounds (TeleRPOID Project).
Acta medica PhilippinaFrom genome to drug targets: computational subtractive genomics reveals novel anti-filarial targets in Wuchereria bancrofti and identifies plant-based inhibitors of β-1,4-mannosyltransferase, a high-priority target.
Molecular diversityGlobal Preventive and Management Strategies and Their Effectiveness in Patients With Secondary Lymphedema: A Scoping Review.
CureusAn Antibody Biomarker Associated with Onchocerca volvulus Microfilariae Identified by Proteomic Analysis of Parasite Tissues Isolated from Paraffin Embedded O. volvulus Nodules by Laser Capture Microdissection.
The American journal of tropical medicine and hygieneGeospatial analysis of Aedes poicilius, vector of Bancroftian Filariasis in the Philippines.
Journal of parasitic diseases : official organ of the Indian Society for ParasitologyWb5, a novel biomarker for monitoring efficacy and success of mass drug administration programs for Wuchereria bancrofti elimination.
PLoS neglected tropical diseasesBreast Filariasis-Diagnosed by Fine Needle Aspiration Cytology: A Rare Case Report.
Cytopathology : official journal of the British Society for Clinical CytologyAntifilarial treatment strategies: a systematic review and network meta-analysis.
BMC infectious diseasesOutcomes and cost-effectiveness of an integrated holistic care package on persons affected by podoconiosis, lymphatic filariasis and leprosy and community members in north-western Ethiopia: an implementation research study.
BMC medicineUrogenital Schistosomiasis Is Associated with an Increased Risk of Plasmodium falciparum Infection in Burkina Faso.
The American journal of tropical medicine and hygieneAdherence to mass drug administration and environmental factors related to lymphatic filariasis incidence: A case-control study in endemic area, Papua, Indonesia.
Narra JQuality of Life of Lower Limb Lymphatic Filariasis Patients in a North Indian Tertiary Care Center: A Prospective Observational Study.
CureusStructural insights of WBmDapE and deciphering of potent anti-filarial inhibitors: a state-of-art computational approach.
Molecular diversityMoxidectin combination therapies for lymphatic filariasis: an open-label, observer-masked, randomised controlled trial.
The Lancet. Infectious diseasesImpact of mass drug administration of ivermectin and albendazole on transmission of Wuchereria bancrofti lymphatic filariasis from 2001 to 2017 in Burkina Faso.
Tropical medicine & international health : TM & IHThe psychosocial and emotional burden of lymphatic filariasis: A systematic review.
PLoS neglected tropical diseasesWhat matters most in Cirebon, Indonesia: cultural nuances to health-related stigma.
Global public healthGlobal, regional, and national disability-adjusted life years and prevalence of lymphatic filariasis from 1990 to 2021: A trend and health inequality analysis based on the global burden of disease study 2021.
PLoS neglected tropical diseasesmGem: Decoding transmicrobe messaging-the growing impact of extracellular vesicles.
mBioVector incrimination studies of lymphatic filariasis in rural areas of endemic Datia district of Madhya Pradesh, India.
Transactions of the Royal Society of Tropical Medicine and HygieneRobust COVID-19 Vaccine Responses Despite Filarial Co-Infection: Insights from a Lymphatic Filariasis Cohort in Ghana.
VaccinesXenomonitoring and Molecular Characterization of Brugia malayi from Mansonia annulifera in Alappuzha, Kerala, India.
Vector borne and zoonotic diseases (Larchmont, N.Y.)Persistent lymphatic filariasis transmission seven years after validation of elimination as a public health problem: a cross-sectional study in Tonga.
The Lancet regional health. Western PacificIntegrated serological surveillance for neglected tropical diseases, vaccine-preventable diseases, and arboviruses in Samoa, 2018.
Scientific reportsBeyond business as usual for lymphatic filariasis mass drug administration in hotspot districts.
International healthCommunity structure of artificial container-breeding mosquitoes (Diptera: Culicidae) and co-occurrence patterns of dengue vectors in mid-western Nepal.
Journal of vector borne diseasesIn vitro larvicidal activity of selected azabenzimidazole and diarylquinoline derivatives against Anopheles gambiae and in silico mechanistic analysis.
Molecular diversityDiagnostic task shifting for NTDs: outcome of a preliminary quasi-experimental study for microfilaria detection using a novel diagnostic device in Nigeria.
African health sciencesGermline transformation of the West Nile virus and avian malaria vector Culex quinquefasciatus Say using the piggyBac transposon system.
Insect biochemistry and molecular biologyValidation of routine lymphatic filariasis morbidity surveillance in the Upper West Region, Ghana.
PLOS global public healthCurrent perspectives in the epidemiology and control of lymphatic filariasis.
Clinical microbiology reviewsBrazil was certified by the World Health Organization for having eliminated lymphatic filariasis: what now?
Parasites & vectorsMicroplanning improves stakeholders' perceived capacity and engagement to implement lymphatic filariasis mass drug administration.
PLoS neglected tropical diseasesAdopting telehealth service for lymphedema care: Insights from a Filariasis Management Clinic, Puducherry, India.
Digital healthNutritional predictors of lymphatic filariasis progression: Insights from a machine learning approach.
PloS oneUnraveling the Dynamics of Human Filarial Infections: Immunological Responses, Host Manifestations, and Pathogen Biology.
Pathogens (Basel, Switzerland)Xenomonitoring as an epidemiological tool supporting post-stop surveillance of albendazole-ivermectin mass drug distribution in the Bougouni-Yanfolila evaluation unit, Sikasso, Mali, in 2023.
BMC infectious diseasesEvaluation of Microfilaremic Individuals after Mass Drug Treatment with Ivermectin, Diethylcarbamazine, and Albendazole for Lymphatic Filariasis in Papua New Guinea.
The American journal of tropical medicine and hygieneAccess, utilisation and barriers to lymphedema care: A mixed method study in Puducherry, India.
Acta tropicaPrevalence of Lymphatic Filariasis based on Morbidity and Healthcare-seeking Practices of Patients in a Gram Panchayat of Paschim Burdwan District, West Bengal.
Indian journal of community medicine : official publication of Indian Association of Preventive & Social MedicineTime to consider doxycycline in the standard treatment of lymphatic filariasis? Emerging evidence on use of doxycycline as an adjunct to hygiene protocols.
Tropical medicine and healthThe launch of the Pacific vector network: connecting Pacific Island Countries and areas to prevent and control vector-borne diseases.
Parasites & vectorsPriority knowledge gaps for schistosomiasis research and development in the World Health Organization Africa Region.
Infectious diseases of povertyProgression of lymphatic filariasis antigenaemia and microfilaraemia over 4.5 years in antigen-positive individuals, Samoa 2019-2023.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious DiseasesCirculating Cell-Free Nucleic Acid Detection for Wuchereria bancrofti Infections.
The Journal of infectious diseasesDevelopment and Assessment of a Multiple-Analysis System for Diagnosing Malaria and Other Blood Parasite Infections in Humans and Non-Human Primates.
Diagnostics (Basel, Switzerland)Malaria and filaria co-infection in a febrile patient.
Tropical doctorImpact of mass drug administration with ivermectin, diethylcarbamazine, and albendazole for lymphatic filariasis on hookworm and Strongyloides stercoralis infections in Papua New Guinea.
PLoS neglected tropical diseasesThe changing funding landscape for infectious disease research and control: implications for resource-limited countries.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious DiseasesPostelimination Cluster of Lymphatic Filariasis, Futuna, 2024.
Emerging infectious diseasesDescribing the interaction between Wuchereria bancrofti glutathione transferase and Bromosulphophthalein from an empirical and theoretical perspective.
International journal of biological macromoleculesAddressing challenges in vector control: a review of current strategies and the imperative for novel tools in India's combat against vector-borne diseases.
BMJ public healthSpreading awareness on lymphatic filariasis.
The Lancet. Infectious diseasesSafety and effectiveness of triple-drug therapy with ivermectin, diethylcarbamazine, and albendazole in reducing lymphatic filariasis prevalence and clearing circulating filarial antigens in Mombasa, Kenya.
Infectious diseases of povertyDescription of four cases of male genital schistosomiasis (MGS) in children and adolescents, with a scoping review.
ParasitologyPrevalence of neglected tropical diseases among migrants living in Europe: A systematic review and meta-analysis.
Travel medicine and infectious diseaseImproving neglected tropical disease services and integration into primary healthcare in Southern Nations, Nationalities and People's Region, Ethiopia: Results from a mixed methods evaluation of feasibility, acceptability and cost effectiveness.
PLoS neglected tropical diseasesA delayed diagnosis of lymphatic filariasis in a returned traveller from the Philippines.
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Emergence of a novel zoonotic brugian filarial infection during post-validation surveillance for lymphatic filariasis in Sri Lanka.
- Cross-sectional study to assess filarial infection among the never treated individuals in selected districts in India: a study protocol.
- Altitudinal and household breeding patterns of the medically important mosquitoes Aedes aegypti, Aedes albopictus and Culex quinquefasciatus in Nepal.
- Noise and neglect: Social-media signals expose attention gaps for dengue, chikungunya, lymphatic filariasis and kala-azar in India's vector-borne NTDs.
- The impact of the termination of Lymphatic Filariasis mass drug administration on Soil-transmitted Helminth prevalence in school children in Malawi.
- Hotspot-based integrated serosurveillance of neglected tropical diseases, malaria, and vaccine-preventable diseases in urban Guyana.
- Public-Private Partnership offers a strategic opportunity for Lymphatic Filariasis Elimination in India by 2030.
- Tetracycline Resistance Pattern Among Lymphatic Filariasis-Hyperendemic Communities in Southern Ghana: A Mixed-Method Approach.
- The influence of human population movement on mass drug administration for neglected tropical diseases: a scoping review.
- Human Filariasis in Africa (2000-2025): Changing epidemiology, uneven diagnostic progress, and persistent neglect.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:2035(Orphanet)
- MONDO:0005761(MONDO)
- GARD:3321(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
- Q192100(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
