Raras
Buscar doenças, sintomas, genes...
Filariose linfática
ORPHA:2035CID-10 · B74.0CID-11 · 1F66.3DOENÇA RARA

Infestação parasitária do sistema linfático humano por wuchereria bancrofti ou brugia malayi. Também é chamada de filariose linfática.

Mantido por Agente Raras·Colaborar como especialista →

Introdução

O que você precisa saber de cara

📋

Infestação parasitária do sistema linfático humano por wuchereria bancrofti ou brugia malayi. Também é chamada de filariose linfática.

Pesquisas ativas
4 ensaios
94 total registrados no ClinicalTrials.gov
Publicações científicas
3.650 artigos
Último publicado: 2026

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
>1 / 1000
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Specific population
Início
All ages
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: B74.0
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🩸
Sangue
6 sintomas
🫘
Rins
5 sintomas
🛡️
Imunológico
3 sintomas
🧬
Pele e cabelo
2 sintomas
🦴
Ossos e articulações
2 sintomas
🫁
Pulmão
2 sintomas

+ 13 sintomas em outras categorias

Características mais comuns

90%prev.
Linfedema
Muito frequente (99-80%)
90%prev.
Linfadenopatia
Muito frequente (99-80%)
90%prev.
Anormalidade do sistema linfático
Muito frequente (99-80%)
90%prev.
Linfedema predominantemente de membros inferiores
Muito frequente (99-80%)
55%prev.
Hiperceratose
Frequente (79-30%)
55%prev.
Complexos imunes circulantes
Frequente (79-30%)
33sintomas
Muito frequente (4)
Frequente (7)
Ocasional (13)
Muito raro (9)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 33 características clínicas mais associadas, ordenadas por frequência.

LinfedemaLymphedema
Muito frequente (99-80%)90%
LinfadenopatiaLymphadenopathy
Muito frequente (99-80%)90%
Anormalidade do sistema linfáticoAbnormality of the lymphatic system
Muito frequente (99-80%)90%
Linfedema predominantemente de membros inferioresPredominantly lower limb lymphedema
Muito frequente (99-80%)90%
HiperceratoseHyperkeratosis
Frequente (79-30%)55%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico3.650PubMed
Últimos 10 anos200publicações
Pico2025159 papers
Linha do tempo
2026Hoje · 2026🧪 1991Primeiro ensaio clínico📈 2025Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
3Fase 37
1Fase 12
·Pré-clínico8
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 17 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Filariose linfática

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

2 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

Outros ensaios clínicos

94 ensaios clínicos encontrados, 4 ativos.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
1.800 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 1.800

#1

Emergence of a novel zoonotic brugian filarial infection during post-validation surveillance for lymphatic filariasis in Sri Lanka.

The Lancet regional health. Southeast Asia2026 Mar

Lymphatic filariasis (LF) affects approximately 120 million people globally and is caused by Wuchereria bancrofti, Brugia malayi and Brugia timori. Sri Lanka was historically endemic for both bancroftian and brugian filariasis, with B. malayi presumed eliminated by the late 1960s. The country achieved validation of LF elimination as a public health problem in 2016. However, sporadic Brugia infections have been detected in microfilaria surveys from the mid-2000s onwards; the sub-periodic periodicity of which is suggestive of a zoonotic origin and warrants further research. Night blood survey (NBS) surveillance was conducted by the Anti-Filariasis Campaign, Ministry of Health, Sri Lanka, from 2019 to 2023. Brugia-positive human samples and archived canine samples were analysed using a next-generation sequencing metabarcoding platform targeting mitochondrial and nuclear loci. Bayesian and neighbour-joining phylogenetic analyses and minimum-spanning network approaches were used to characterise lineage relationships. Among 1,855,165 individuals screened, 52 were identified with Brugia-like microfilariae. Metabarcoding generated 1.2 million high-quality reads with both mitochondrial cox1 and ribosomal DNA markers confirming a single Brugia lineage circulating in humans, mainly in children. Sequences of the c ox1 gene showed 99.4-100 percent nucleotide identity to the Brugia Sri Lanka (SL) genotype previously detected in dogs in Sri Lanka and Tamil Nadu (India). rDNA sequences showed low similarity to B. malayi or Brugia pahangi, indicating that the parasite represents a distinct Brugia taxon lacking a reference rDNA sequence. The findings provide evidence that human brugian filariasis in Sri Lanka is caused by a previously unrecognised zoonotic Brugia species maintained in dogs. This has important clinical and public health implications given that human infections have occurred in children despite LF being declared eliminated as a public health problem. Crucially, the incorrect classification of circulating filarioid species may lead to inappropriate clinical and programmatic responses. For example, the newly identified canine reservoir of this Brugia genotype means that human-only mass drug administration might not be sufficient to interrupt this species' transmission. These results underscore the need for integrated One Health surveillance to prevent re-establishment of LF and safeguard regional elimination goals. No specific funding was received for the present study. This study was supported by a consulting funding (PRJ_002971).

#2

Cross-sectional study to assess filarial infection among the never treated individuals in selected districts in India: a study protocol.

BMJ open2026 Mar 19

With the global lymphatic filariasis (LF) elimination goal set to 2030, it is necessary to address challenges hindering the last-mile efforts. Never treated individuals are those who self-report that they have never taken the drugs for LF during any mass drug administration (MDA) rounds. Hence, it is necessary to identify these individuals and assess if they can be potential reservoirs of infection and understand the reasons for non-compliance. This mixed method study, proposed for a period of 2 years, will assess the filarial infection status of never treated individuals from four LF-endemic districts in India. A multi-stage cluster sampling design will be followed to select the health subcentres from one highly endemic block in each of the selected districts. A random sample of 2535 never treated individuals from each block will be assessed for filarial infection by a cross-sectional blood survey. Qualitative surveys, including in-depth interviews and focus group discussions, will be conducted to elicit the reasons for their non-compliance. The prevalence of filarial infection will be summarised as frequencies and percentages. Univariate and multivariate logistic regression analysis will be performed to find the factors associated with filarial infection. Exploring the various reasons, such as sociocultural, behavioural and programmatic drivers of non-participation, will enable the programme to design tailored communication and community engagement strategies to bring them under the umbrella of MDA and thereby support the ongoing LF elimination efforts. This study has been approved by the institutional ethics committee (IHEC 07-0824/N/F, dated 25 September 2024). After completion of the study, a workshop will be held with all stakeholders to disseminate the study findings.

#3

Altitudinal and household breeding patterns of the medically important mosquitoes Aedes aegypti, Aedes albopictus and Culex quinquefasciatus in Nepal.

PloS one2026

Medically relevant mosquitoes have established populations across Nepal, adapting to diverse environmental conditions and altitudes. In addition to arbovirus vectors, the presence of Culex quinquefasciatus, a primary vector of lymphatic filariasis, underscores the need for comprehensive mosquito surveillance. This study investigated the presence, abundance, container preferences, and altitudinal distribution of Aedes aegypti, Aedes albopictus, and Cx. quinquefasciatus across selected districts in Nepal. We also examined the co-occurrence of Aedes species and their association with container type and location. An entomological survey was conducted along an altitudinal transect from 140 meters above sea level (m asl) (Chitwan) to 2340 m asl (Dolakha). Immatures were collected from 1,157 water-holding containers across 636 households using dipper and dropper techniques, while adults were captured using BG-Sentinel traps. Immatures were reared to adulthood for identification, while non-reared specimens were identified via microscopic slides. A total of 1,323 immature and 158 adult mosquitoes were recorded. Among immatures, Ae. albopictus (47.6%) was the most abundant, followed by Ae. aegypti (43.4%). Adults were predominantly Cx. quinquefasciatus (82.9%). Plastic bottles and drums were the most common larval habitats. Aedes species were found across the study transect, from 140 to 2066 m asl. The altitude did not have a statistically significant effect on the number of collected mosquitoes (p = 0.563). These findings highlight the widespread presence of Aedes and Culex species across different altitudes and breeding habitats. The predominance and co-occurrence of dengue vectors and Cx. quinquefasciatus in nearby households underscore the need for integrated vector surveillance and control strategies in Nepal.

#4

Noise and neglect: Social-media signals expose attention gaps for dengue, chikungunya, lymphatic filariasis and kala-azar in India's vector-borne NTDs.

PLoS neglected tropical diseases2026 Mar

Neglected tropical and vector-borne diseases, including dengue, chikungunya, lymphatic filariasis, and kala-azar, pose substantial public health burdens in India. Despite WHO recommendations for enhanced disease surveillance and targeted communication strategies, little is known about public perceptions and discussions of these diseases across digital platforms. Understanding these perceptions can guide evidence-based policy making and public health messaging. We conducted an in silico analysis of publicly accessible social and news media data related to dengue, chikungunya, filariasis, and kala-azar in India from January 2019 to December 2023. YouTube comments and Google News headlines were systematically retrieved, pre-processed, and analysed through sentiment analysis (VADER lexicon) and Latent Dirichlet Allocation (LDA) topic modelling. Facebook and Twitter data were not included due to Application programming interface (API) restrictions and their current subscription-based models, limiting free access even for research purposes. We visualized disease-specific digital attention in comparison to epidemiological burden and created chord, Sankey, and network diagrams to elucidate thematic and sentiment-based interactions. Across keyword-matched items (n = 330), dengue accounted for 173 (~52%) and also had the highest mean annual reported burden (163,679 cases/year; 2019-2023). Lymphatic filariasis showed disproportionately high attention (106 items/mentions vs 3,060 reported cases/year), while kala-azar had minimal visibility (5 items; none on YouTube). Sentiment was overall neutral-to-positive, with Google News more neutral and YouTube more positive. Topics emphasized outbreak alerts, public-health campaigns, and prevention/treatment, with recurring vaccine/innovation themes. Our study presents a novel approach combining digital surveillance, sentiment analysis, and topic modelling to provide insights into public perceptions of NTDs in India. The observed mismatch between epidemiological burden and online attention underscores the need for strategic public health messaging, aligning with WHO recommendations for community engagement and tailored disease-awareness campaigns. This research provides a valuable tool for policymakers to enhance the effectiveness of communication strategies and improve targeted intervention planning for neglected tropical diseases in India.

#5

The impact of the termination of Lymphatic Filariasis mass drug administration on Soil-transmitted Helminth prevalence in school children in Malawi.

PLoS neglected tropical diseases2026 Feb

Soil-transmitted helminths (STH) have been passively targeted through the implementation of mass drug administration (MDA), with the drugs ivermectin and albendazole, against the parasitic disease, lymphatic filariasis (LF). In Malawi, LF MDA was administered to communities between 2008 and 2014. The aim of this analysis was to estimate the impact of LF MDA and its termination on STH prevalence in school aged children (SAC). School survey data of STH prevalence in Malawi were obtained through the ESPEN website. The surveys spanned the periods before (1998-2004), during (2012-2014) and after LF MDA (2015-2019). Bayesian mixed-effects models were fitted to estimate the impact of LF MDA termination, and other STH risk factors, on the odds of infection, as well as generate predictions of nationwide STH prevalence during and after LF MDA. SAC after the termination of LF MDA had 1.8 times greater odds of A. lumbricoides infection compared to SAC during the implementation of LF MDA (95% credible interval (CI): 1.03 - 3.35), despite ongoing STH preventive chemotherapy (PC) targeting SAC. Predictions indicate majority of districts increased in their probability of exceeding 2% A. lumbricoides prevalence in SAC after the termination of LF MDA, with Chitipa, Mulanje and Nsanje districts estimated to have > 80% probability of exceeding 2% prevalence. An overall resurgence in A. lumbricoides infections after LF MDA was estimated in SAC, despite ongoing annual STH PC. This suggests STH PC could not sustain the prevalence levels achieved in SAC under community-wide LF MDA. The potential role of drug resistance in this resurgence calls for urgent investigation. Understanding how this resurgence corresponds to prevalence of moderate and heavy infections should be a priority for future research.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC1.783 artigos no totalmostrando 197

2026

Emergence of a novel zoonotic brugian filarial infection during post-validation surveillance for lymphatic filariasis in Sri Lanka.

The Lancet regional health. Southeast Asia
2026

Lived experiences, stigma and impacts of lymphatic filariasis: a scoping review.

International health
2026

Cross-sectional study to assess filarial infection among the never treated individuals in selected districts in India: a study protocol.

BMJ open
2026

Altitudinal and household breeding patterns of the medically important mosquitoes Aedes aegypti, Aedes albopictus and Culex quinquefasciatus in Nepal.

PloS one
2026

Noise and neglect: Social-media signals expose attention gaps for dengue, chikungunya, lymphatic filariasis and kala-azar in India's vector-borne NTDs.

PLoS neglected tropical diseases
2026

Circumferential Negative Pressure Lymphedema Therapy: A Novel Rapid Perioperative Decongestion Strategy for Advanced Stage III-IV Lymphedema.

Cureus
2026

High prevalence of bancroftian filariasis and comorbidities in the eastern coalfield regions of West Bengal, India following COVID-19 disruption.

Scientific reports
2026

Biochemical, molecular, and in silico insights into the effects of cyphenothrin on Culex quinquefasciatus mosquitoes.

Parasites &amp; vectors
2026

Cost-Effectiveness of Triple Versus Dual-Drug Therapy for Elimination of Lymphatic Filariasis in India.

Value in health regional issues
2026

Post elimination of lymphatic filariasis: a situation analysis of brugian filariasis and vector potentialities within the filarial transmission belt in Sri Lanka.

Parasites &amp; vectors
2026

From neglect to empowerment: impact of vocational rehabilitation on quality of life among disabled filarial lymphoedema patients in a brugian-endemic region of South India-a mixed methods evaluation.

Transactions of the Royal Society of Tropical Medicine and Hygiene
2026

Sociodemographic determinants of lymphatic filariasis knowledge among refugees in Cameroon.

Discover public health
2025

Design of an implementation research study for a digital omnichannel community engagement and risk communication intervention for the prevention and control of vector-borne diseases in India: the OMNIVEC-India study protocol.

Frontiers in public health
2026

High-Dose Rifampicin Plus Albendazole Rapidly Clears Lymphatic Filariasis Circulating Filarial Antigen in a Randomised Clinical Trial: A Promising Step Toward Short-Course Macrofilaricidal Therapy.

Pathogens (Basel, Switzerland)
2026

Enablers of Post-Validation Surveillance for Lymphatic Filariasis in the Pacific Islands: A Nominal Group Technique and Expert Elicitation.

Tropical medicine and infectious disease
2026

Integrated Approaches to Surveillance of Lymphatic Filariasis and Other Infectious Diseases in the Pacific Islands.

Tropical medicine and infectious disease
2026

The impact of the termination of Lymphatic Filariasis mass drug administration on Soil-transmitted Helminth prevalence in school children in Malawi.

PLoS neglected tropical diseases
2026

Measuring Progress of 2030 Skin-Related Neglected Tropical Diseases Sustainable Development Goals.

JAMA dermatology
2026

Deep phenotypic profiling uncovers cryptic effects of antifilarial drugs.

bioRxiv : the preprint server for biology
2026

Phytol from Sphaeranthus indicus: A Natural Insecticide Against Aedes aegypti and Culex quinquefasciatus.

Acta parasitologica
2026

Vulval Lymphedema: An Under-Recognized Clinical Manifestation of Lymphatic Filariasis.

The American journal of tropical medicine and hygiene
2026

Establishing a filarial clinical research platform in a resource-limited setting: Lessons and experiences from Tanzania.

PLoS neglected tropical diseases
2026

Defining onchocerciasis transmission zones: Integrating operational insights with genomic and ecological advances.

International health
2025

Review of selected mosquito-borne diseases: arboviruses (dengue, chikungunya, Zika, West Nile, Japanese encephalitis, yellow fever) and parasitic diseases (malaria, lymphatic Filariasis).

Frontiers in public health
2026

The Death to Onchocerciasis and Lymphatic Filariasis (DOLF) project: Accomplishments and ongoing research.

PLoS neglected tropical diseases
2026

Cross-sectional epidemiological assessment of lymphatic filariasis situation in areas under post-mass drug administration surveillance and the associated risk of transmission in the context of migrants in India: a study protocol.

BMJ open
2026

Global Lymphatic Filariasis Post-Validation Surveillance Activities in 2025: A Scoping Review.

Tropical medicine and infectious disease
2026

Barriers and Facilitators to Implementing Post-Validation Surveillance of Lymphatic Filariasis in Pacific Island Countries and Territories: A Conceptual Framework Developed from Qualitative Data.

Tropical medicine and infectious disease
2025

Finding the Gaps: Integrated Serosurveillance and Spatial Clustering of Vaccine Preventable Diseases in Samoa, 2018-2019.

Tropical medicine and infectious disease
2025

Spatial Risk Factors of Vector-Borne Diseases in Pacific Island Countries and Territories: A Scoping Review.

Tropical medicine and infectious disease
2025

Vitamin A and D levels in patients with filarial lymphedema and healthy volunteers in Puducherry, India.

Frontiers in nutrition
2026

Transmission status of lymphatic filariasis in hotspots of filarial infection, persistent districts of nepal during post-MDA surveillance.

PloS one
2026

Patient perspectives and barriers to effective home-based care in lymphatic filariasis: A mixed methods study from Puducherry, India.

PLoS neglected tropical diseases
2026

Exploring the landscape of lymphatic filariasis research in India: A scientometric analysis of two decades from 2000 to 2024.

PLoS neglected tropical diseases
2026

Do we have a match? Calculating the potential for integrating neglected tropical disease control programmes for sustainable public health policy.

Acta tropica
2025

Neglected by Design: Occupational Parasitic Infections in India's Lower Castes.

The Yale journal of biology and medicine
2025

Living with Filariasis: Unseen Struggles of a Neglected Disease.

The Yale journal of biology and medicine
2025

Meta-analysis of the prevalence of lymphatic filariasis infection in mosquito vectors.

Frontiers in cellular and infection microbiology
2025

Neglected tropical diseases elimination in Africa: lessons from regional control programmes.

Tropical medicine and health
2025

Assessment of mosquito species communities biting humans and their livestock in the forest hills of Karen state, Myanmar: a cross-sectional survey in six villages.

Parasites &amp; vectors
2025

Lymphatic Filariasis in India: A Historical and Contemporary Overview.

Journal of vector borne diseases
2026

Family quality of life and associated factors among people with leprosy or podoconiosis/lymphatic filariasis with visible disabilities and their family members in Ethiopia: a baseline study for a randomized controlled trial.

Transactions of the Royal Society of Tropical Medicine and Hygiene
2025

Reversal of filarial serpin Wb123-urokinase plasminogen activator receptor mediated alternative macrophage activation by monoclonal antibody.

PLoS neglected tropical diseases
2026

Larvicidal and macrofilaricidal efficacy of closantel and morantel against mosquito larvae and Setaria digitata nematodes.

Experimental parasitology
2025

Revisiting the epidemiology of schistosomiasis and soil-transmitted helminthiasis in Chad: insights for improved interventions.

International health
2025

The role of molecular xenomonitoring for assessing the impact of Ivermectin, Diethylcarbamazine Citrate and Albendazole triple-drug treatment against lymphatic filariasis: A cross-sectional study in the Kenyan coastal region.

PLOS global public health
2025

Diethylcarbamazine elicits calcium signals by activation of Brugia malayi TRP-2b channels heterologously expressed in HEK293 cells.

Scientific reports
2025

Wbm0152, an outer membrane lipoprotein of the Wolbachia endosymbiont of Brugia malayi, inhibits yeast ESCRT complex activity.

PLoS pathogens
2025

Two decades of filariasis in India: Insights into prevalence, diagnostic challenges, and strategies for elimination by 2027.

IJID regions
2025

Coverage evaluation of mass drug administration for lymphatic filariasis in four endemic districts of Jharkhand, India.

Journal of health, population, and nutrition
2025

Bayesian hierarchical spatial ecological model assessing the nexus of vegetation index, insecticide-treated bed-nets and livestock cattle density on lymphatic filariasis transmission.

BMC public health
2025

Risk factors of lymphatic filariasis in Asia: a systematic review.

BMC infectious diseases
2025

Semi-annual and annual mass drug administration of diethylcarbamazine and albendazole are equally effective regimens for eliminating lymphatic filariasis in Papua New Guinea.

PLoS neglected tropical diseases
2026

Elephantiasis and verrucous lesions in an Ethiopian man living in Italy.

Journal of infection and public health
2025

Community engagement in mass drug administration participatory interventions: A scoping review.

PLoS neglected tropical diseases
2025

Molecular Characterisation of Fungi Populations in the Chronic Wounds of Filarial Lymphedema Patients in Southern Ghana: A Cross-Sectional Study.

Health science reports
2025

Determining Etiology of Elephantiasis and Associated Factors in Hawella Tula, Sidama Region, Ethiopia.

Research and reports in tropical medicine
2025

A framework for guiding integrated disease control measures through multipathogen surveillance.

medRxiv : the preprint server for health sciences
2025

Field trial finds promising evidence on Spinosad: a bio-larvicide for mosquito control in urban settings in Bengaluru, India.

Malaria journal
2025

Achieving elimination of soil-transmitted helminthiasis as a public health problem in Mali.

BMJ global health
2025

Structure-based virtual screening of β-tubulin and thioredoxin reductase in Brugia malayi: a step toward novel anti-filarial agents.

In silico pharmacology
2025

Lymphatic filariasis remained silent until presentation with huge abdominal mass mimicking malignancy: a case report.

ASM case reports
2025

Blood parasitic diseases in India: Current landscape, challenges, and the road ahead.

Tropical parasitology
2025

Implementation of basic package of care improved socio-economic conditions of lymphedema patients in rural Mali after two years follow-up.

PLOS global public health
2025

Double Trouble in the Thyroid: Coexistence of Hurthle Cell Neoplasm and Microfilarial Infestation.

Discoveries (Craiova, Romania)
2025

Anopheles barbirostris in Indonesia: A more complex metapopulation than expected.

PloS one
2025

Brugia malayi miRNAs and potential targets within the feline host (Felis catus).

Current research in parasitology &amp; vector-borne diseases
2025

In silico screening of flavonoid-based inhibitors targeting UDP-galactopyranose mutase of Brugia malayi for lymphatic filariasis drug design.

Computers in biology and medicine
2025

Clinical Manifestations of Lymphatic Filariasis and Practice of Vector Control Measures after 15 Years of Mass Drug Administration: A Rapid Epidemiological Study from Odisha.

Indian journal of community medicine : official publication of Indian Association of Preventive &amp; Social Medicine
2025

COMET-LF: a compartmental model of dynamics of infection, disease, and elimination strategies for lymphatic filariasis.

BMC infectious diseases
2025

Patient journeys for neglected tropical diseases in rural sub-Saharan Africa: a scoping review.

Infectious diseases of poverty
2025

Prevalence of Malaria Among Individuals Living With Lymphedema in Kamwenge District, Western Uganda.

Cureus
2025

Investigating the resurgence of malaria in Rwanda: factors contributing to rising cases amidst near-eradication success and strategies for sustained control.

Annals of medicine and surgery (2012)
2025

Identification of key pharmacophore feature motifs from the potent leads of the major antioxidant enzymes of W. bancrofti and in vitro validation studies of the key enzyme WbPrx6 using the model organism S. digitata.

Computers in biology and medicine
2025

Acute Brugian filariasis in a German tourist after short-term travel to Sri Lanka, 2025.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
2025

Molecular xenomonitoring highlights post-MDA surveillance priorities for sustained Wuchereria bancrofti elimination in Burkina Faso.

Tropical medicine and health
2025

Comparison of Platelet Functions, Plasma Proteins and Lipids in Filarial and Non-Filarial Edema Patients.

Parasite immunology
2025

Zoonotic brugian filariasis past and present trends in malaysia: A systematic review and proportionate meta-analysis.

Scientific reports
2025

Moxidectin combination therapies for lymphatic filariasis-36-month follow-up.

The Lancet. Infectious diseases
2025

A Triple Regimen as an Alternative Treatment for Lymphatic Filariasis in a Non-endemic Area in Indonesia: A Case Report.

Cureus
2025

Structural Barriers and the Future of AI in Global Health: Lessons From Eradicable Diseases.

Cureus
2025

Piloting lymphoedema management for lymphatic filariasis: experiences and perceptions of patients and stakeholders from Kwale county, coastal Kenya.

BMC public health
2025

Brugia malayi and other filarial parasite species in animals in areas endemic for lymphatic filariasis in Belitung District, Indonesia.

PLoS neglected tropical diseases
2025

Global Epidemiology of Vector-Borne Parasitic Diseases: Burden, Trends, Disparities, and Forecasts (1990-2036).

Pathogens (Basel, Switzerland)
2025

No evidence of Wuchereria bancrofti infection in Anopheles species after 10 years without mass drug administration: a molecular xenomonitoring study in Hauts-Bassins, Burkina Faso.

Tropical medicine and health
2025

From Burden to Breakthrough: The Impact of Mass Drug Campaigns on Microfilaria Trends Based on Evidence From Sentinel Site Surveillance in Rural Nagpur, Maharashtra, India, Over Two Decades.

Cureus
2026

Active constituent nonacosane from Sphaeranthus indicus (Asterales: Asteraceae) leaves as a potent larvicidal agent against Aedes aegypti (Diptera: Culicidae) and Culex quinquefasciatus (Diptera: Culicidae).

Parasitology international
2025

Detection of potential transmission foci of lymphatic filariasis using molecular xenomonitoring in Huahine, French Polynesia.

PLoS neglected tropical diseases
2025

Assessing the need to implement mass drug administration against Wuchereria bancrofti infection using both human serology and xenomonitoring in the urban conurbation of Monrovia, Liberia.

PLoS neglected tropical diseases
2025

A multicenter evaluation of the Filariasis IgG4 Rapid Test for detection of lymphatic filariasis.

Acta tropica
2026

"String sign"- acute lymphangitis in the forearm following triple drug therapy for bancroftian filarial infection.

Journal of vector borne diseases
2025

Positive allosteric modulation of emodepside sensitive Brugia malayi SLO-1F and Onchocerca volvulus SLO-1A potassium channels by GoSlo-SR-5-69.

PLoS pathogens
2025

Harnessing the potential of phytochemicals to design anti-filarial molecules targeting the MurE enzyme of Brugia malayi: a hierarchical virtual screening and molecular dynamics simulation study.

SAR and QSAR in environmental research
2025

Impact of diabetes mellitus on adenolymphangitis episodes in patients with filarial lymphedema-Towards an integrated care approach.

PLoS neglected tropical diseases
2025

Unlocking the blueprint to eliminating neglected tropical diseases: A review of efforts in 50 countries that have eliminated at least 1 NTD.

PLoS neglected tropical diseases
2025

Larvicidal mechanism of the rare sesquiterpene ishwarol B from Piper alatipetiolatum (Piperaceae) against Aedes aegypti, Anopheles darlingi, and Culex quinquefasciatus (Culicidae): oxidative damage, defense enzyme modulation, and acetylcholinesterase inhibition.

Chemico-biological interactions
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The Impact of Displacement on Skin-Related Neglected Tropical Diseases in Sudan.

Clinical and experimental dermatology
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The Burden of Neglected Tropical Diseases in Rwanda: A Scoping Review.

Health science reports
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Clinical profile and Mass Drug Administration coverage in patients with lymphatic filariasis: A descriptive study.

Journal of family medicine and primary care
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A virtual screening strategy to repurpose antifolate compounds as W.bancrofti DHFR inhibitors.

Bioorganic &amp; medicinal chemistry letters
2025

Social and healthcare-seeking experiences of people affected with lymphedema in Bangladesh.

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Lymphoedema - Filariasis or soft tissue sarcoma? A case report.

Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia
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Confirmatory mapping for lymphatic filariasis a decade after baseline endemicity assessment in highly urbanized settings of Lagos, Nigeria.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
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Effects of doxycycline on prepatent and patent infections of Brugia pahangi in dogs and observations on the growth and survival of L3 in jirds and dogs.

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Acta parasitologica
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Detection of Filarial IgG and IgM Antibodies Among Individuals With Lymphedema in the Kamwenge District, Western Uganda.

Cureus
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Public health surveillance of tropical diseases in Madagascar: a scoping review of population burden, intervention strategies, and health system responses.

BMC public health
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Current Gaps in Survey Design and Analysis for Molecular Xenomonitoring of Vector-Borne Neglected Tropical Diseases: A Systematic Review.

Tropical medicine &amp; international health : TM &amp; IH
2025

Access and Awareness of Morbidity Management and Disability Prevention for Lower Limb Lymphatic Filariasis in Post-Mass Drug Administration Districts in Southern India.

The American journal of tropical medicine and hygiene
2025

Preliminary evaluation of inactivated antigens as diagnostic controls in molecular detection of vector-borne diseases in low-resource settings.

Journal of vector borne diseases
2025

Feasibility of interrupting the transmission of soil-transmitted helminths: the DeWorm3 community cluster-randomised controlled trial in Benin, India, and Malawi.

Lancet (London, England)
2025

Epidemiological monitoring survey to assess the impact of mass drug administration with triple-drug regimen in lymphatic filariasis elimination programme in an endemic district in Southern India.

PLoS neglected tropical diseases
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The changing neglected tropical disease landscape in Africa: implications for policy, practice, and strengthening health systems.

Health affairs scholar
2025

Influence of the physicochemical characteristics of mosquito breeding sites in domestic environments on the distributions of Anopheles, Aedes and Culex mosquitoes in Benin.

Tropical medicine and health
2025

Field evaluation of Standard Q Filariasis Antigen Test for Lymphatic Filariasis (LF) during a pre-transmission assessment survey in Sierra Leone, 2022.

PLoS neglected tropical diseases
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Sequence Localization of SeGPx in S. digitata Genome Contigs and Determination of its Presence in the Whole Worm Extract.

Acta parasitologica
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Averting collapse: Reimagining the NTDs ecosystem through G20 health diplomacy and science innovation.

Microbes and infection
2025

Acceptability of mass drug administration for lymphatic filariasis in Baglung Municipality of Nepal: A mixed-method study.

PLOS global public health
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Exploring the Antibacterial, Antioxidant and Larvicidal Effects against Culex quinquefasciatus of Nigella sativa Seeds and its Silver Nanoparticles.

Acta parasitologica
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Integrating geospatial tools is crucial for enhancing control strategies against human lymphatic filarial infections in Ghana: A comprehensive review.

Parasite epidemiology and control
2025

Testicular Lymphatic Filariasis.

Radiographics : a review publication of the Radiological Society of North America, Inc
2025

Host environment shapes filarial parasite fitness and Wolbachia endosymbionts dynamics.

PLoS pathogens
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Reactive case detection can improve the efficiency of lymphatic filariasis surveillance compared to random sampling, Samoa 2023.

PLoS neglected tropical diseases
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Global insights can accelerate India's journey towards the elimination of lymphatic filariasis as a public health problem.

BMJ global health
2025

Evaluating the effectiveness of mass drug administration on lymphatic filariasis transmission and assessment of post-mass drug administration surveillance in Nigeria's Federal Capital Territory.

Infectious diseases of poverty
2025

Healthcare Undergraduates' Perception and Practice Regarding Lymphatic Filariasis and Mass Drug Administration in a Tertiary Care Facility in Eastern India.

Cureus
2025

A mixed-method study to improve outcome of mass drug administration in two TAS failed districts of Uttar Pradesh, India.

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Prevalence and patterns of multiple long-term conditions among lymphatic filariasis patients in Odisha, India: a community-based cross-sectional study.

BMC public health
2026

Coverage and determinants of Mass Drug Administration against lymphatic filariasis in Southeast Asian regional countries during the end-game strategy: A systematic review and meta-analysis.

Journal of vector borne diseases
2025

Comparative analysis of skin microbiome of patients with filarial lymphedema and healthy individuals.

PloS one
2025

Assessment of the effectiveness of public art in improving knowledge, attitude, practices and mitigation of stigmatization regarding neglected tropical diseases in South Eastern, Nigeria.

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A Next-Generation Human Lymphatic Filariasis Vaccine Candidate, rBmHAXT, for Clinical Development.

Research square
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Structure-based designing of anti-filarial molecules targeting the key antioxidant enzyme glutathione peroxidase (GPx) of Wuchereria bancrofti: An integrated in silico and in vitro approach.

Computers in biology and medicine
2025

Examining the overlap in lymphatic filariasis prevalence and malaria insecticide-treated net access-use in endemic Africa.

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Evaluation of sampling strategies for assessing lymphatic filariasis endemic status of a non-MDA district in South India.

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Overexpression of cytochrome P450 and esterase genes in pyrethroid-resistant wild Culex quinquefasciatus populations from sub-Himalayan West Bengal, India.

Parasitology research
2025

Uncertainty quantification in cost-effectiveness analysis for stochastic-based infectious disease models: Insights from surveillance on lymphatic filariasis.

Journal of theoretical biology
2025

Lymphatic filariasis: from neglected tropical disease to national priority.

The Lancet. Infectious diseases
2025

Community views on mass drug administration for soil-transmitted helminths: a qualitative evidence synthesis.

The Cochrane database of systematic reviews
2025

The Feasibility of Using Telehealth for Training Health Care Workers and Persons with Disability on Integrated Rehabilitation and Prevention of Impairments and Disabilities of Leprosy, Lymphatic Filariasis, Diabetes, Pressure Ulcers, and Other Chronic Wounds (TeleRPOID Project).

Acta medica Philippina
2026

From genome to drug targets: computational subtractive genomics reveals novel anti-filarial targets in Wuchereria bancrofti and identifies plant-based inhibitors of β-1,4-mannosyltransferase, a high-priority target.

Molecular diversity
2025

Global Preventive and Management Strategies and Their Effectiveness in Patients With Secondary Lymphedema: A Scoping Review.

Cureus
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An Antibody Biomarker Associated with Onchocerca volvulus Microfilariae Identified by Proteomic Analysis of Parasite Tissues Isolated from Paraffin Embedded O. volvulus Nodules by Laser Capture Microdissection.

The American journal of tropical medicine and hygiene
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Geospatial analysis of Aedes poicilius, vector of Bancroftian Filariasis in the Philippines.

Journal of parasitic diseases : official organ of the Indian Society for Parasitology
2025

Wb5, a novel biomarker for monitoring efficacy and success of mass drug administration programs for Wuchereria bancrofti elimination.

PLoS neglected tropical diseases
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Breast Filariasis-Diagnosed by Fine Needle Aspiration Cytology: A Rare Case Report.

Cytopathology : official journal of the British Society for Clinical Cytology
2025

Antifilarial treatment strategies: a systematic review and network meta-analysis.

BMC infectious diseases
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Outcomes and cost-effectiveness of an integrated holistic care package on persons affected by podoconiosis, lymphatic filariasis and leprosy and community members in north-western Ethiopia: an implementation research study.

BMC medicine
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Urogenital Schistosomiasis Is Associated with an Increased Risk of Plasmodium falciparum Infection in Burkina Faso.

The American journal of tropical medicine and hygiene
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Adherence to mass drug administration and environmental factors related to lymphatic filariasis incidence: A case-control study in endemic area, Papua, Indonesia.

Narra J
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Quality of Life of Lower Limb Lymphatic Filariasis Patients in a North Indian Tertiary Care Center: A Prospective Observational Study.

Cureus
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Structural insights of WBmDapE and deciphering of potent anti-filarial inhibitors: a state-of-art computational approach.

Molecular diversity
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Moxidectin combination therapies for lymphatic filariasis: an open-label, observer-masked, randomised controlled trial.

The Lancet. Infectious diseases
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Impact of mass drug administration of ivermectin and albendazole on transmission of Wuchereria bancrofti lymphatic filariasis from 2001 to 2017 in Burkina Faso.

Tropical medicine &amp; international health : TM &amp; IH
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The psychosocial and emotional burden of lymphatic filariasis: A systematic review.

PLoS neglected tropical diseases
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What matters most in Cirebon, Indonesia: cultural nuances to health-related stigma.

Global public health
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Global, regional, and national disability-adjusted life years and prevalence of lymphatic filariasis from 1990 to 2021: A trend and health inequality analysis based on the global burden of disease study 2021.

PLoS neglected tropical diseases
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mGem: Decoding transmicrobe messaging-the growing impact of extracellular vesicles.

mBio
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Vector incrimination studies of lymphatic filariasis in rural areas of endemic Datia district of Madhya Pradesh, India.

Transactions of the Royal Society of Tropical Medicine and Hygiene
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Robust COVID-19 Vaccine Responses Despite Filarial Co-Infection: Insights from a Lymphatic Filariasis Cohort in Ghana.

Vaccines
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Xenomonitoring and Molecular Characterization of Brugia malayi from Mansonia annulifera in Alappuzha, Kerala, India.

Vector borne and zoonotic diseases (Larchmont, N.Y.)
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Persistent lymphatic filariasis transmission seven years after validation of elimination as a public health problem: a cross-sectional study in Tonga.

The Lancet regional health. Western Pacific
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Integrated serological surveillance for neglected tropical diseases, vaccine-preventable diseases, and arboviruses in Samoa, 2018.

Scientific reports
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Beyond business as usual for lymphatic filariasis mass drug administration in hotspot districts.

International health
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Community structure of artificial container-breeding mosquitoes (Diptera: Culicidae) and co-occurrence patterns of dengue vectors in mid-western Nepal.

Journal of vector borne diseases
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In vitro larvicidal activity of selected azabenzimidazole and diarylquinoline derivatives against Anopheles gambiae and in silico mechanistic analysis.

Molecular diversity
2024

Diagnostic task shifting for NTDs: outcome of a preliminary quasi-experimental study for microfilaria detection using a novel diagnostic device in Nigeria.

African health sciences
2025

Germline transformation of the West Nile virus and avian malaria vector Culex quinquefasciatus Say using the piggyBac transposon system.

Insect biochemistry and molecular biology
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Validation of routine lymphatic filariasis morbidity surveillance in the Upper West Region, Ghana.

PLOS global public health
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Current perspectives in the epidemiology and control of lymphatic filariasis.

Clinical microbiology reviews
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Brazil was certified by the World Health Organization for having eliminated lymphatic filariasis: what now?

Parasites &amp; vectors
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Microplanning improves stakeholders' perceived capacity and engagement to implement lymphatic filariasis mass drug administration.

PLoS neglected tropical diseases
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Adopting telehealth service for lymphedema care: Insights from a Filariasis Management Clinic, Puducherry, India.

Digital health
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PloS one
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Unraveling the Dynamics of Human Filarial Infections: Immunological Responses, Host Manifestations, and Pathogen Biology.

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Xenomonitoring as an epidemiological tool supporting post-stop surveillance of albendazole-ivermectin mass drug distribution in the Bougouni-Yanfolila evaluation unit, Sikasso, Mali, in 2023.

BMC infectious diseases
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Evaluation of Microfilaremic Individuals after Mass Drug Treatment with Ivermectin, Diethylcarbamazine, and Albendazole for Lymphatic Filariasis in Papua New Guinea.

The American journal of tropical medicine and hygiene
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Access, utilisation and barriers to lymphedema care: A mixed method study in Puducherry, India.

Acta tropica
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Prevalence of Lymphatic Filariasis based on Morbidity and Healthcare-seeking Practices of Patients in a Gram Panchayat of Paschim Burdwan District, West Bengal.

Indian journal of community medicine : official publication of Indian Association of Preventive &amp; Social Medicine
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Time to consider doxycycline in the standard treatment of lymphatic filariasis? Emerging evidence on use of doxycycline as an adjunct to hygiene protocols.

Tropical medicine and health
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The launch of the Pacific vector network: connecting Pacific Island Countries and areas to prevent and control vector-borne diseases.

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Priority knowledge gaps for schistosomiasis research and development in the World Health Organization Africa Region.

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Progression of lymphatic filariasis antigenaemia and microfilaraemia over 4.5 years in antigen-positive individuals, Samoa 2019-2023.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
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Circulating Cell-Free Nucleic Acid Detection for Wuchereria bancrofti Infections.

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Development and Assessment of a Multiple-Analysis System for Diagnosing Malaria and Other Blood Parasite Infections in Humans and Non-Human Primates.

Diagnostics (Basel, Switzerland)
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Malaria and filaria co-infection in a febrile patient.

Tropical doctor
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Impact of mass drug administration with ivermectin, diethylcarbamazine, and albendazole for lymphatic filariasis on hookworm and Strongyloides stercoralis infections in Papua New Guinea.

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The changing funding landscape for infectious disease research and control: implications for resource-limited countries.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
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Postelimination Cluster of Lymphatic Filariasis, Futuna, 2024.

Emerging infectious diseases
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Describing the interaction between Wuchereria bancrofti glutathione transferase and Bromosulphophthalein from an empirical and theoretical perspective.

International journal of biological macromolecules
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Addressing challenges in vector control: a review of current strategies and the imperative for novel tools in India's combat against vector-borne diseases.

BMJ public health
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Spreading awareness on lymphatic filariasis.

The Lancet. Infectious diseases
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Safety and effectiveness of triple-drug therapy with ivermectin, diethylcarbamazine, and albendazole in reducing lymphatic filariasis prevalence and clearing circulating filarial antigens in Mombasa, Kenya.

Infectious diseases of poverty
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Description of four cases of male genital schistosomiasis (MGS) in children and adolescents, with a scoping review.

Parasitology
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Prevalence of neglected tropical diseases among migrants living in Europe: A systematic review and meta-analysis.

Travel medicine and infectious disease
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Improving neglected tropical disease services and integration into primary healthcare in Southern Nations, Nationalities and People's Region, Ethiopia: Results from a mixed methods evaluation of feasibility, acceptability and cost effectiveness.

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A delayed diagnosis of lymphatic filariasis in a returned traveller from the Philippines.

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Emergence of a novel zoonotic brugian filarial infection during post-validation surveillance for lymphatic filariasis in Sri Lanka.
    The Lancet regional health. Southeast Asia· 2026· PMID 41868817mais citado
  2. Cross-sectional study to assess filarial infection among the never treated individuals in selected districts in India: a study protocol.
    BMJ open· 2026· PMID 41856581mais citado
  3. Altitudinal and household breeding patterns of the medically important mosquitoes Aedes aegypti, Aedes albopictus and Culex quinquefasciatus in Nepal.
    PloS one· 2026· PMID 41855226mais citado
  4. Noise and neglect: Social-media signals expose attention gaps for dengue, chikungunya, lymphatic filariasis and kala-azar in India's vector-borne NTDs.
    PLoS neglected tropical diseases· 2026· PMID 41849302mais citado
  5. The impact of the termination of Lymphatic Filariasis mass drug administration on Soil-transmitted Helminth prevalence in school children in Malawi.
    PLoS neglected tropical diseases· 2026· PMID 41739877mais citado
  6. Hotspot-based integrated serosurveillance of neglected tropical diseases, malaria, and vaccine-preventable diseases in urban Guyana.
    Rev Panam Salud Publica· 2026· PMID 41982851recente
  7. Public-Private Partnership offers a strategic opportunity for Lymphatic Filariasis Elimination in India by 2030.
    Acta Trop· 2026· PMID 41951149recente
  8. Tetracycline Resistance Pattern Among Lymphatic Filariasis-Hyperendemic Communities in Southern Ghana: A Mixed-Method Approach.
    Health Sci Rep· 2026· PMID 41948629recente
  9. The influence of human population movement on mass drug administration for neglected tropical diseases: a scoping review.
    Infect Dis Poverty· 2026· PMID 41947206recente
  10. Human Filariasis in Africa (2000-2025): Changing epidemiology, uneven diagnostic progress, and persistent neglect.
    PLoS Negl Trop Dis· 2026· PMID 41945600recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:2035(Orphanet)
  2. MONDO:0005761(MONDO)
  3. GARD:3321(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Artigo Wikipedia(Wikipedia)
  6. Q192100(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Filariose linfática
Compêndio · Raras BR

Filariose linfática

ORPHA:2035 · MONDO:0005761
Prevalência
>1 / 1000
Herança
Not applicable
CID-10
B74.0 · Filariose por Wuchereria bancrofti
CID-11
Ensaios
4 ativos
Início
All ages
Prevalência
0.0 (Specific population)
MedGen
UMLS
C0013884
Repurposing
1 candidato
diethylcarbamazinelipoxygenase inhibitor
EuropePMC
Wikidata
Wikipedia
Papers 10a
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