Um linfoma não Hodgkin de linhagem de células T. Inclui o linfoma linfoblástico T e os linfomas de células T e NK maduras.
Introdução
O que você precisa saber de cara
Um linfoma não Hodgkin de linhagem de células T. Inclui o linfoma linfoblástico T e os linfomas de células T e NK maduras.
Tem tratamento?
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 19 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 54 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
13 genes identificados com associação a esta condição.
Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand (PubMed:24825777). Regulates macrophage activation (PubMed:11823861). Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance (PubMed:14556005). In CD8+ cells attenuates T
Cell membraneCell junction
Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system (PubMed:11121404, PubMed:11387242, PubMed:16317043, PubMed:17274988, PubMed:30061385, PubMed:34646012, PubMed:34819673). Also acts as a key thinness protein involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a nega
Cell membrane
Receptor with high affinity for TNFSF2/TNF and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF. Isoform 2 blocks TNF-induced apoptosis, which suggests that it regulates TNF function by antagonizing its biological activity
Cell membraneSecreted
Receptor that plays a role in T-cell activation, proliferation, survival and the maintenance of immune homeostasis (PubMed:1650475, PubMed:7568038). Functions not only as an amplifier of TCR signals but delivers unique signals that control intracellular biochemical events that alter the gene expression program of T-cells (PubMed:24665965). Stimulation upon engagement of its cognate ligands CD80 or CD86 increases proliferation and expression of various cytokines in particular IL2 production in bo
Cell membraneCell surface
Immunodeficiency 123 with HPV-related verrucosis
An autosomal recessive immunologic disorder characterized by susceptibility to human papilloma virus (HPV) infections and the development of HPV-related common verrucosis in the first decade of life. In some patients with HPV2 infection, warts may progress to severe generalized hyperkeratotic cutaneous papillomatosis with cutaneous horns ('tree-man' phenotype). In patients with HPV4 infection, warts remains stable and may even regress with age.
Inhibitory receptor acting as a major negative regulator of T-cell responses (PubMed:11279501, PubMed:11279502, PubMed:16551244, PubMed:1714933, PubMed:18641304, PubMed:28484017). Acts as a decoy receptor: the affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28 (PubMed:11279501, PubMed:11279502, PubMed:16551244, PubMed:1714933, PubMed:28484017)
Cell membrane
Systemic lupus erythematosus
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:16239216, PubMed:28111307, PubMed:32750333, PubMed:7615558, PubMed:8232552). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952). Kinase partner for the type I interferon receptor IFNAR2 (PubMed:16239216, PubMed:28111307, PubMed:32750333, PubMed:7615558, PubMed:8232552). In response to interferon-binding to IFNAR1-IFNAR2
Endomembrane system
Autoinflammation, immune dysregulation, and eosinophilia
An autosomal dominant disorder characterized by immune dysregulation, severe atopic dermatitis, and chronic gastrointestinal inflammation. Additional features include asthma, food or environmental allergies, as well as poor overall growth with short stature.
E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular path
NucleusChromosomeCytoplasm
Breast cancer
A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case.
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stran
Nucleus, nucleolusNucleus, nucleoplasmCytoplasm, cytoskeleton, microtubule organizing center, centrosome
Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:35618207, PubMed:36634798, PubMed:38653238, PubMed:9840937). Acts as a tumor suppressor in many tumor types; induces growth arrest or apop
CytoplasmNucleusNucleus, PML bodyEndoplasmic reticulumMitochondrion matrixCytoplasm, cytoskeleton, microtubule organizing center, centrosome
Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May
NucleusCytoplasm, cytoskeleton, microtubule organizing center, centrosome
Breast cancer
A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case.
Tyrosine kinase of the non-receptor type involved in numerous cytokines and interferons signaling, which regulates cell growth, development, cell migration, innate and adaptive immunity (PubMed:10542297, PubMed:10995743, PubMed:7657660, PubMed:7813427, PubMed:8232552). Plays both structural and catalytic roles in numerous interleukins and interferons (IFN-alpha/beta) signaling (PubMed:10542297). Associates with heterodimeric cytokine receptor complexes and activates STAT family members including
Immunodeficiency 35
A primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin receptor (MPL/TPOR); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and
Endomembrane systemCytoplasmNucleus
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:15653507, PubMed:16285960, PubMed:17344214, PubMed:18242580, PubMed:18782771, PubMed:22306293, PubMed:23084476, PubMed:28262505, PubMed:32929201, PubMed:38404237). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:15653507, Pu
CytoplasmNucleus
Hyper-IgE syndrome 1, autosomal dominant, with recurrent infections
A rare disorder of immunity and connective tissue characterized by immunodeficiency, chronic eosinophilia, distinctive coarse facial appearance, abnormal dentition, hyperextensibility of the joints, and bone fractures.
Medicamentos e terapias
Mecanismo: Tubulin inhibitor
Mecanismo: Glucocorticoid receptor agonist
Mecanismo: Glucocorticoid receptor agonist
Mecanismo: C-C chemokine receptor type 4 cross-linking agent
Mecanismo: Dihydrofolate reductase inhibitor
Mecanismo: Glucocorticoid receptor agonist
Mecanismo: Glucocorticoid receptor agonist
Mecanismo: Retinoid X receptor agonist
Mecanismo: Dihydrofolate reductase inhibitor
Mecanismo: Histone deacetylase inhibitor
Variantes genéticas (ClinVar)
4,925 variantes patogênicas registradas no ClinVar.
Vias biológicas (Reactome)
150 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Linfoma não-Hodgkin de células T
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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
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Outros ensaios clínicos
Publicações mais relevantes
Incidence of Hypertension During Induction Therapy in Children with Acute Lymphoblastic Leukemia.
To estimate the incidence of hypertension during induction therapy in children with acute lymphoblastic leukemia (ALL), comparing a systematically monitored prospective cohort to a retrospective cohort lacking regular blood pressure monitoring. This ambispective observational study was conducted at a pediatric hematology-oncology unit in Chandigarh, India. The prospective cohort included 46 children with B-/T-ALL or T-cell non-Hodgkin lymphoma enrolled between September 2023 and August 2024, whose blood pressure was monitored weekly during induction therapy using the auscultatory method with an aneroid sphygmomanometer. Hypertension was defined according to the 2017 American Academy of Pediatrics guidelines. The retrospective cohort comprised 160 children diagnosed between June 2022 and July 2023, whose case files were reviewed for documented hypertension or posterior reversible encephalopathy syndrome (PRES). In the retrospective cohort, blood pressure was not monitored systematically and was detected incidentally during routine care or at the time of admission for intercurrent illnesses. Hypertension was observed in 27 (58.7%) patients in the prospective cohort, compared to 20 (12.5%) in the retrospective (P < 0.001). Most (92.6%) cases of hypertension in the prospective cohort occurred within the first two weeks of induction. No case vs. two (1.3%) cases of PRES were reported in the prospective and retrospective cohorts. The incidence of hypertension during induction therapy in childhood ALL was 58.7%, with most cases occurring within the first two weeks. Incorporating blood pressure monitoring into routine care is essential for children with ALL receiving induction chemotherapy.
[Research Progress in ALK+/- Anaplastic Large Cell Lymphoma--Review].
Anaplastic large cell lymphoma (ALCL) is a rare CD30-positive T-cell non-Hodgkin lymphoma, primarily classified into two subtypes: ALK-positive ( ALK +) and ALK-negative ( ALK -). ALK + ALCL is commonly seen in younger patients and characterized by rapid progression, with the majority of patients achieving complete remission after chemotherapy. In contrast, ALK -ALCL generally affects older patients, presenting with similar clinical features but a poorer prognosis. Genetic rearrangements, such as DUSP22 and TP63, have a significant impact on patient survival. The current treatment regimen primarily involves CHOP, but its efficacy is limited, especially in relapsed cases. Consequently, there is an urgent need to improve frontline and salvage treatment options. Future research should focus on the integration of targeted therapies with molecular mechanisms to enhance therapeutic outcomes and survival rates. Understanding the subtypes and molecular characteristics of ALCL is essential for optimizing therapeutic strategies. Therefore, this review summarizes recent research advances on ALK +/- ALCL to provide insights for optimizing treatment approaches. ALK +/-间变性大细胞淋巴瘤的研究进展. 间变性大细胞淋巴瘤（ALCL）是一种罕见的CD30阳性T细胞非霍奇金淋巴瘤，主要分为 ALK基因重排阳性（ ALK +）和 ALK基因重排阴性（ ALK -）两种亚型。 ALK +ALCL常见于年轻患者，具有快速发展的特征，多数患者在化疗后可得到完全缓解。相比之下， ALK -ALCL患者年龄通常较大，虽然临床表现相似，但预后较差，相关基因重排（如DUSP22 和TP63）对患者生存率有显著影响。目前的治疗方案以CHOP为主，但疗效有限，特别是在复发病例中。因此，亟需改进一线治疗及挽救性方案。未来的研究应关注靶向治疗与分子机制的结合，以提高患者的治疗效果和生存 率。而理解ALCL的亚型和分子特征对于优化治疗策略至关重要，因此，本文对 ALK +/-ALCL的研究进展进行综述，以期为优化治疗策略提供参考。 .
Flaccid Lower Limb Paraparesis Despite Infiltration of the Spinal Cord by a Secondary Central Nervous System T-cell Non-Hodgkin Lymphoma With Syringomyelia: A Case Report.
Secondary central nervous system (CNS) lymphomas typically present with weakness, spasticity, exaggerated tendon reflexes, and pyramidal signs. A patient with progressive flaccid paraparesis of the lower extremities despite carcinomatosis and infiltration of T-cell non-Hodgkin lymphoma (NHL) into the spinal cord has not been described to date. A 71-year-old man was diagnosed with T-cell NHL not otherwise specified, stage 4B, and an international prognostic index of 5 based on a lymph node biopsy and bone marrow puncture. The patient received three cycles of cyclophosphamide, hydroxydaunorubicin, vincristine, and prednisone (CHOP) chemotherapy, which had to be discontinued due to thrombocytopenia and the onset of paraparesis of the lower extremities. Examination of the paraparesis revealed lymphoma infiltrates in the brain and spinal cord. Despite these CNS lesions, the patient did not exhibit spasticity, pyramidal signs, or increased reflexes; rather, hypotonia and a general absence of reflexes were observed. These were attributed to axonal motor neuropathy due to vincristine toxicity. T-cell NHL may not be suppressed by CHOP chemotherapy, may spread secondarily to the CNS, and may infiltrate the brain and spinal cord, manifesting as paraparesis, incontinence, muscle hypotonia, and decreased tendon reflexes. Secondary CNS lymphoma does not necessarily have to be accompanied by hyperreflexia, pyramidal signs, and spasticity if the peripheral nerves are severely affected by vincristine toxicity.
Retrospective analysis of clinical characteristics, treatment outcomes and prognosis of patients with natural killer/T-cell lymphoma.
Natural killer/T-cell lymphoma (NKTCL) is the most common T-cell non-Hodgkin lymphoma in China; however, the clinical characteristics and optimal treatment remain unclear. The present study aimed to retrospectively assess the clinical features of patients with NKTCL and to determine treatment strategies. A total of 200 patients who were diagnosed with NKTCL and admitted to the Cancer Center, Union Hospital (Wuhan, China) between June 2013 and June 2022 were identified. Clinical data from these patients were collected and analyzed to evaluate the clinical features, treatment outcomes and prognostic factors. A total of 171 patients diagnosed with NKTCL were ultimately enrolled. Patients were diagnosed at a median age of 45 years and had a male-to-female ratio of 2:1. Out of the 171 patients, 117 were in the early stage (stage I/II; 68.4%) and 54 were in the advanced stage (stage III/IV; 31.6%) of NKTCL. Among these patients, B symptoms were present in 60.2% of patients (103/171) and the Eastern Cooperative Oncology Group performance status was scored as 0-1 in 93.6% of patients (160/171). Most patients had a low-to-moderate risk of international prognostic index (147/171; 86.0%), prognostic index for NKTCL (PINK; 122/171; 71.3%) and PINK with extended features (112/171; 65.5%). At baseline, it was demonstrated that Epstein-Barr virus DNA was positive in the serum of 166/171 patients (2.9%). Combined chemotherapy and radiotherapy at 54 Gy revealed a promising effect with the highest overall response rate (ORR) of 98.2%, a 4-year progression-free survival (PFS) rate of 82.5% [95% confidence interval (CI), 75.1-89.9%] and an overall survival (OS) rate of 92.2% (95% CI, 86.9-97.5%) for the early-stage group. Pegasparase-based chemotherapy was used to treat advanced-stage patients, resulting in a 4-year PFS rate of 62.3% (95% CI, 47.4-77.2%) and an OS rate of 63.5% (95% CI, 48.2-78.8%). The regimen containing the programmed cell death protein 1 inhibitor camrelizumab demonstrated an ORR of 100% in both the early- and advanced-stage cohorts. Moreover, stage and an age of >60 years were independent prognostic factors for poor PFS, whilst stage and elevated lactate dehydrogenase were independent prognostic factors for poor OS. In conclusion, the results indicated promising efficacy for pegaspargase-based chemotherapy in terms of response rates and survival outcomes for both early- and advanced-stage patients. However, further refinement of treatment strategies is needed.
Advances and updates in pediatric anaplastic large cell lymphoma.
Anaplastic large cell lymphoma (ALCL) is a rare form of mature T-cell non-Hodgkin lymphoma. In pediatric patients, most cases are anaplastic lymphoma kinase (ALK) positive. Despite intensive multiagent chemotherapy regimens, treatment failure rates remain at 25% to 30%. Recent advancements in targeted therapies, notably ALK inhibitors and the anti-CD30 antibody-drug conjugate brentuximab vedotin have demonstrated substantial activity in relapsed and refractory settings. Molecular detection of minimal disseminated disease (MDD) and minimal residual disease (MRD) offers improved prognostic stratification. For patients with relapsed or refractory disease, targeted therapies have increased treatment options, but more work needs to be done to define optimal treatment regimens, duration, and need for hematopoietic stem cell transplantation in this group. Immune therapies such as checkpoint inhibitors or chimeric antigen receptor T-cell therapy provide additional therapeutic options. Incorporating targeted therapies and MDD/MRD assessments into clinical trials could significantly improve outcomes for pediatric and adolescent patients with ALCL.
Publicações recentes
Case Report: A case of jejunal T-cell non-Hodgkin lymphoma with secondary bone involvement presenting as gastrointestinal perforation.
[Research Progress in ALK(+/-) Anaplastic Large Cell Lymphoma--Review].
Flaccid Lower Limb Paraparesis Despite Infiltration of the Spinal Cord by a Secondary Central Nervous System T-cell Non-Hodgkin Lymphoma With Syringomyelia: A Case Report.
Case Report: diffuse entire gastrointestinal tract involvement of ALK-positive anaplastic large cell lymphoma harboring JAK-STAT pathway mutations in an adolescent with leukemoid reaction.
Anaplastic Lymphoma Kinase (ALK)-Positive Anaplastic Large Cell Lymphoma Presenting as an Axillary Breast Abscess in a Young Woman: A Case Report.
📚 EuropePMC80 artigos no totalmostrando 132
[Research Progress in ALK+/- Anaplastic Large Cell Lymphoma--Review].
Zhongguo shi yan xue ye xue za zhiFlaccid Lower Limb Paraparesis Despite Infiltration of the Spinal Cord by a Secondary Central Nervous System T-cell Non-Hodgkin Lymphoma With Syringomyelia: A Case Report.
CureusCase Report: diffuse entire gastrointestinal tract involvement of ALK-positive anaplastic large cell lymphoma harboring JAK-STAT pathway mutations in an adolescent with leukemoid reaction.
Frontiers in oncologyAnaplastic Lymphoma Kinase (ALK)-Positive Anaplastic Large Cell Lymphoma Presenting as an Axillary Breast Abscess in a Young Woman: A Case Report.
CureusRetrospective analysis of clinical characteristics, treatment outcomes and prognosis of patients with natural killer/T-cell lymphoma.
Oncology lettersIncidence trends and survival analysis of enteropathy-associated T-cell lymphoma.
Frontiers in immunologyIncidence of Hypertension During Induction Therapy in Children with Acute Lymphoblastic Leukemia.
Indian pediatricsSweet Syndrome-like Dermatosis as a Precursor to Overlapping Hematologic Malignancies: A Case Report and Review.
Journal of clinical medicineAdvances and updates in pediatric anaplastic large cell lymphoma.
Blood advancesBIA-ALCL diagnosis: the relevance of cytology and flow cytometry in periprosthetic fluid analysis.
Annales de biologie cliniqueCoexistence of T-Cell Lymphoblastic Lymphoma and Ichthyosis Vulgaris: A Case Report.
Case reports in oncological medicineLong-term survival and clinical implications of allogeneic stem cell transplantation in relapse/refractory lymphoma: A 20-year Singapore experience.
Annals of the Academy of Medicine, SingaporeHSP-CAR30 with a high proportion of less-differentiated T cells promotes durable responses in refractory CD30+ lymphoma.
BloodPeripheral T-cell lymphoma-NOS in children and adolescents: a review from the Children's Oncology Group NHL Committee.
Blood advancesEnhancement of High-Dose Chemotherapy and Autologous SCT with the PARP Inhibitor Olaparib for Refractory Lymphoma.
Clinical cancer research : an official journal of the American Association for Cancer ResearchSpontaneous regression in mature T-cell non-Hodgkin lymphoma.
Expert review of hematologyTumour assessment of ROR1 levels in various adult leukaemia and lymphoma types.
PloS oneBreast Implant-Associated Anaplastic Large Cell Lymphoma: Where Hematology and Plastic Surgery Meet.
Clinical lymphoma, myeloma & leukemiaFlow Cytometry Analysis in Breast Implant-Associated Anaplastic Large Cell Lymphoma: Three Case Reports.
International journal of molecular sciencesDisseminated Anaplastic Lymphoma Kinase (ALK)-Positive T-cell Lymphoma Involving the Uterus and Cervix: A Case Report.
CureusCase report: The utilization of crizotinib and brentuximab vedotin as a bridge to autologous stem cell transplantation and followed by CD30-directed CAR-T cell therapy in relapsed/refractory ALK+ ALCL.
Frontiers in immunologyIncidental Bystander or Essential Culprit: A Systematic Review of Bacterial Significance in the Pathogenesis of Breast Implant-Associated Anaplastic Large Cell Lymphoma.
International journal of molecular sciencesA pancreatic puzzle: A T-cell non-Hodgkin lymphoma in a 3-year-old child with acute pancreatitis.
Indian journal of gastroenterology : official journal of the Indian Society of GastroenterologyIntraoperative pathologic diagnosis of central nervous system lymphomas: A comparison of frozen and permanent section diagnoses, and the significance of preoperative imaging.
Annals of diagnostic pathologyUpdate on the Pathogenesis of Enteropathy-Associated T-Cell Lymphoma.
Diagnostics (Basel, Switzerland)Chimeric Antigen Receptor T Cells in Hodgkin and T-Cell Lymphomas.
Hematology/oncology clinics of North AmericaA phase 2 study of pembrolizumab after autologous stem cell transplantation in patients with T-cell non-Hodgkin lymphoma.
BloodZidovudine and Interferon Alfa based regimens for the treatment of adult T-cell leukemia/lymphoma (ATLL): a systematic review and meta-analysis.
Virology journalBrentuximab vedotin use in pediatric anaplastic large cell lymphoma.
Frontiers in immunologyTextured vs. Smooth Breast Implants Using the Jones Criteria-What Is the Currently Available Evidence for BIA-ALCL?: A Systematic Review.
Journal of personalized medicineMassive myocardial infiltration by primary anaplastic T-cell lymphoma: a case report.
European heart journal. Case reportsA Rare Case of Metachronous Peripheral T-cell Non-Hodgkin Lymphoma Following Epstein-barr Virus-positive Diffuse Large B-cell Lymphoma, Not Otherwise Specified.
Oman medical journalAre we there yet? cellular therapies for cutaneous T cell lymphoma.
Current research in translational medicineIncreasing Risk of Lymphoma Over Time in Crohn's Disease but Not in Ulcerative Colitis: A Scandinavian Cohort Study.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological AssociationFirst-Line Therapy for Nodal T-cell Non-Hodgkin Lymphomas: an Unmet Need in Hematology.
Current oncology reportsPotential miRNA-gene interactions determining progression of various ATLL cancer subtypes after infection by HTLV-1 oncovirus.
BMC medical genomicsPrimary Gastrointestinal T-cell Lymphoma Presenting as Spontaneous Perforation Peritonitis.
CureusSafety and efficacy of dual PI3K-δ, γ inhibitor, duvelisib in patients with relapsed or refractory lymphoid neoplasms: A systematic review and meta-analysis of prospective clinical trials.
Frontiers in immunologySBNO2 is a critical mediator of STAT3-driven hematological malignancies.
BloodSurgical management of monomorphic epitheliotropic intestinal T-cell lymphoma followed by chemotherapy and stem-cell transplant: A case report and review of the literature.
World journal of gastrointestinal oncologyInter-intra instrument comparison and standardization of a 10-color immunophenotyping for B and T cell non-Hodgkin lymphoma diagnosis and monitoring.
Journal of immunological methodsHepatosplenic T-Cell Non-Hodgkin Lymphoma Cured with Tandem Autologous and Allogeneic Stem Cell Transplantation.
ChemotherapyT-Cell Non-Hodgkin Lymphoma of the Ileum Presenting as Perforation and Peritonitis: A Case Report.
Frontiers in surgeryAn Updated Approach and Understanding of Breast Implant-Associated Anaplastic Large Cell Lymphoma.
Journal of the National Comprehensive Cancer Network : JNCCNSting Is Commonly and Differentially Expressed in T- and Nk-Cell but Not B-Cell Non-Hodgkin Lymphomas.
CancersImmunohistochemical evaluation and prognostic value of monocarboxylate transporter 1 (MCT1) and 4 (MCT4) in T-cell non-Hodgkin lymphoma.
Clinical and experimental medicineImpact of conditioning regimen intensity on the outcomes of peripheral T-cell lymphoma, anaplastic large cell lymphoma and angioimmunoblastic T-cell lymphoma patients undergoing allogeneic transplant.
British journal of haematologyCoexistence of T-Large Granular Lymphocyte Leukemia and Peripheral T Cell Lymphoma-NOS with Indolent Behavior.
Mediterranean journal of hematology and infectious diseasesSevere Generalized Weakness, Paraplegia following administration of Oxaliplatin in a patient with refractory T-cell non-Hodgkin lymphoma: A case report.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy PractitionersUkrainian prospective study in patients with T-cell non-Hodgkin lymphomas.
Experimental oncologyPrimary gastrointestinal anaplastic large cell lymphoma: A critical reappraisal with a systematic review of the world literature.
Journal of cancer research and therapeuticsPrognostic evaluation models for primary thyroid lymphoma, based on the SEER database and an external validation cohort.
Journal of endocrinological investigationMetagenomic analysis to identify novel infectious agents in systemic anaplastic large cell lymphoma.
Infectious agents and cancerBIA-ALCL diagnosis on CytoLyt fixed ThinPrep, cell block and immunohistochemistry.
Diagnostic cytopathologyBreast implant-associated anaplastic large cell lymphoma (BIA-ALCL): a good practice guide, pictorial review, and new perspectives.
Clinical radiologyFlow Cytometric Detection of the Double-Positive (CD4+CD8+)/PD-1bright T-Cell Subset Is Useful in Diagnosing Nodular Lymphocyte-Predominant Hodgkin Lymphoma.
Archives of pathology & laboratory medicineThe management of breast implant-associated anaplastic large cell lymphoma in the setting of pregnancy: seeking for clinical practice guidelines.
Archives of plastic surgeryEpstein-Barr virus positive diffuse large B-cell lymphoma transformed into angioimmunoblastic T-cell lymphoma after treatment.
Clinical case reportsMRI features of breast implant-associated anaplastic large cell lymphoma.
The British journal of radiologyPost-Chemotherapy Rebound Thymic Hyperplasia Mimicking Relapse in Breast Implant-Associated Anaplastic Large Cell Lymphoma: A Case Report.
Oncology research and treatmentHow I Diagnose Anaplastic Large Cell Lymphoma.
American journal of clinical pathologyTwo young patients with extranodal natural killer/T-cell non-Hodgkin lymphoma, nasal-type (ENKTL-NT) masquerading inflammatory processes: A case series.
Taiwan journal of ophthalmologyA randomized phase 3 trial of autologous vs allogeneic transplantation as part of first-line therapy in poor-risk peripheral T-NHL.
BloodUK Guidelines on the Diagnosis and Treatment of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) on behalf of the Medicines and Healthcare products Regulatory Agency (MHRA) Plastic, Reconstructive and Aesthetic Surgery Expert Advisory Group (PRASEAG).
Journal of plastic, reconstructive & aesthetic surgery : JPRASBreast implant-associated anaplastic large-cell lymphoma (BIA-ALCL).
Yeungnam University journal of medicineNK/T-cell non-Hodgkin lymphoma: Case report and review of the literature.
Experimental and therapeutic medicineUK Guidelines on the Diagnosis and Treatment of Breast Implant-Associated Anaplastic Large Cell Lymphoma on behalf of the Medicines and Healthcare products Regulatory Agency Plastic, Reconstructive and Aesthetic Surgery Expert Advisory Group.
British journal of haematologyThe effect of PD-1 expression on tumor-associated macrophage in T cell lymphoma.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of MexicoFANCA, TP53, and del(5q)/RPS14 alterations in a patient with T-cell non-Hodgkin lymphoma and concomitant Fanconi anemia and Li-Fraumeni syndrome.
Cancer geneticsA case of metachronous peripheral T-Cell non-Hodgkin lymphoma following chemotherapy for Hodgkin disease successfully treated with brentuximab vedotin.
Clinical case reportsHematopoietic Cell Transplantation and Adoptive Cell Therapy in Peripheral T Cell Lymphoma.
Current hematologic malignancy reportsImproved outcomes with allogeneic compared with autologous stem cell transplantation in aggressive T-cell lymphoma.
European journal of haematologyPredicting worse survival for newly diagnosed T cell lymphoma based on the decreased baseline CD16-/CD16 + monocyte ratio.
Scientific reportsGamma-Delta T-Cell Acute Lymphoblastic Leukemia/Lymphoma: Immunophenotype of Three Adult Cases.
Journal of hematologyAberrant CD3-Positive, CD8-Low, CD7-Negative Lymphocytes May Appear During Viral Infections and Mimic Peripheral T-Cell Lymphoma.
Diagnostics (Basel, Switzerland)Primary dural lymphomas: Clinical presentation, management, and outcome.
CancerDiagnostic utility of STAT6YE361 expression in classical Hodgkin lymphoma and related entities.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, IncRefined Disease Risk Index for Hematological Malignancies, Including Rare Disorders, After Allogeneic Stem Cell Transplantation.
Transplantation proceedingsA Diagnostic Dilemma of Sinonasal T Cell Lymphoma: Report of A Unique Case and Literature Review.
The Gulf journal of oncologyThe application of antigen receptor gene rearrangement of BIOMED-2 in the pathologic diagnosis of 348 cases with non-Hodgkin lymphoma in a single institution in Southwest of China.
Pathology, research and practiceIdentification of a new family of pyrazolo[3,4-d]pyrimidine derivatives as multitarget Fyn-Blk-Lyn inhibitors active on B- and T-lymphoma cell lines.
European journal of medicinal chemistryBeneficial effect of consolidative radiotherapy for patients with lymphoma and skeletal involvement.
MedicineCytological features of breast implant-associated anaplastic large cell lymphoma in pleural effusion.
Diagnostic cytopathologyPeripheral T-Cell Lymphoma: Moving Toward Targeted Therapies.
Hematology/oncology clinics of North AmericaOntogeny, Genetics, Molecular Biology, and Classification of B- and T-Cell Non-Hodgkin Lymphoma.
Hematology/oncology clinics of North AmericaChronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) associated with or without lymphoma: Comparison of clinical features and risk factors suggestive of underlying lymphomas.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of AustralasiaThe prognostic value of toll-like receptor5 and programmed cell death-ligand1 in patients with peripheral T-cell non-Hodgkin lymphoma.
Leukemia & lymphomaCharacteristics, treatment patterns, prognostic determinants and outcome of peripheral T cell lymphoma and natural killer/T cell non-Hodgkin Lymphoma in older patients: The result of the nationwide multi-institutional registry Thai Lymphoma Study Group.
Journal of geriatric oncologyGenetics of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL).
Aesthetic surgery journalFrom bench to bedside: the past, present and future of therapy for systemic paediatric ALCL, ALK.
British journal of haematologyAutologous transplantation as consolidation for high risk aggressive T-cell non-Hodgkin lymphoma: a SWOG 9704 intergroup trial subgroup analysis.
Leukemia & lymphomaA phase II study of a modified hyper-CVAD frontline therapy for patients with adverse risk diffuse large B-cell and peripheral T-cell non-Hodgkin lymphoma.
Leukemia & lymphomaAlteration of gene expression profile in CD3+ T-cells after downregulating MALT1.
ImmunoTargets and therapyPeripheral T-cell non-Hodgkin lymphoma manifesting as a primary lesion on the lip: A rare case report.
Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric DentistryCurrent Immunotherapeutic Approaches in T Cell Non-Hodgkin Lymphomas.
CancersHow I treat breast implant-associated anaplastic large cell lymphoma.
BloodExpression of PD-1 on peripheral blood Treg cells is related to the diagnosis, prognosis and treatment of T cell non-Hodgkin lymphoma.
Leukemia researchAggressive Angioimmunoblastic T Cell Lymphomas (AITL) with Soft Tissue Extranodal Mass Varied Histopathological Patterns with Peripheral Blood, Bone Marrow, and Splenic Involvement and Review of Literature.
Indian journal of surgical oncologyEvaluation of tenascin-C by tenatumomab in T-cell non-Hodgkin lymphomas identifies a new target for radioimmunotherapy.
OncotargetUmbralisib, a novel PI3Kδ and casein kinase-1ε inhibitor, in relapsed or refractory chronic lymphocytic leukaemia and lymphoma: an open-label, phase 1, dose-escalation, first-in-human study.
The Lancet. OncologyEosinophilic infiltrate resembling eosinophilic cellulitis (Wells syndrome) in a patient with mycosis fungoides.
Dermatology online journalBreast necrosis in a patient with primary T-cell non-Hodgkin lymphoma.
Cirugia espanolaA Phase I Dose-Escalation Study of Clofarabine in Patients with Relapsed or Refractory Low-Grade or Intermediate-Grade B-Cell or T-Cell Lymphoma.
The oncologistClinicopathological characteristics of T-cell non-Hodgkin lymphoma arising in patients with immunodeficiencies: a single-center case series of 25 patients and a review of the literature.
HaematologicaBlueprint unknown: a case for multidisciplinary management of advanced penile mycosis fungoides.
The Canadian journal of urologyCo-targeting aurora kinase with PD-L1 and PI3K abrogates immune checkpoint mediated proliferation in peripheral T-cell lymphoma: a novel therapeutic strategy.
OncotargetOccupational ultraviolet exposure and risk of non-Hodgkin's lymphomas: a meta-analysis.
OncotargetAutoimmune manifestations associated with lymphoma: characteristics and outcome in a multicenter retrospective cohort study.
Leukemia & lymphomaMyxoid variant of primary cutaneous anaplastic large cell lymphoma: First 2 cases.
Journal of cutaneous pathologyCardiac Hematological Malignancies: Typical Growth Patterns, Imaging Features, and Clinical Outcome.
AngiologyPatients with Fever of Unknown Origin and Splenomegaly: Diagnostic Value of Splenectomy and Preoperative Risk Factors Suggestive of Underlying Lymphomas.
Acta haematologicaDemodicosis in Pediatric Cancer.
Journal of pediatric hematology/oncologyThe prognostic value of 18-FDG positron emission tomography in T cell non-Hodgkin lymphoma.
Blood cancer journalAn audit of patients with mature T-cell non-Hodgkin lymphoma by transplant status in Tasmania.
Internal medicine journalAccuracy of 18-F FDG PET/CT to detect bone marrow clearance in patients with peripheral T-cell lymphoma - tissue remains the issue.
Leukemia & lymphomaThe Activating NKG2C Receptor Is Significantly Reduced in NK Cells after Allogeneic Stem Cell Transplantation in Patients with Severe Graft-versus-Host Disease.
International journal of molecular sciencesImmune Thrombocytopenia in a Child with T Cell Lymphoblastic Lymphoma.
Case reports in hematologyAn unusual extranodal T-cell non-Hodgkin lymphoma.
Lancet (London, England)[Intestinal infiltration of high-grade large T-cell non-Hodgkin lymphoma with cyclin-D1 overexpression and aberrant CD79a expression in a patient with a diagnosis of tumour stage mycosis fungoides].
Gastroenterologia y hepatologiaAdult systemic anaplastic large-cell lymphoma: recommendations for diagnosis and management.
Expert review of hematologyDose-Effect Relationship of Alkylating Agents on Testicular Function in Male Survivors of Childhood Lymphoma.
Pediatric hematology and oncologyIdentification of a new subclass of ALK-negative ALCL expressing aberrant levels of ERBB4 transcripts.
Blood[Constitutional mismatch repair deficiency syndrome].
Nederlands tijdschrift voor geneeskundeT-cell lymphoma with von Hippel-Lindau disease: a rare case report and review of literature.
International journal of clinical and experimental pathology[T-cell non-Hodgkin lymphoma as a rare mycosis fungoide complication].
Revista espanola de geriatria y gerontologiaGenetics of anaplastic large cell lymphoma.
Leukemia & lymphomaPrimary T-Cell Non-Hodgkin Lymphoma of the Vagina.
Case reports in obstetrics and gynecologyPhase II Intergroup Trial of Alisertib in Relapsed and Refractory Peripheral T-Cell Lymphoma and Transformed Mycosis Fungoides: SWOG 1108.
Journal of clinical oncology : official journal of the American Society of Clinical OncologyConstitutive control of AKT1 gene expression by JUNB/CJUN in ALK+ anaplastic large-cell lymphoma: a novel crosstalk mechanism.
LeukemiaEnteropathy-associated T-cell lymphoma: improving treatment strategies.
Digestive diseases (Basel, Switzerland)[Safety of polyethylene glycol conjugated L-asparaginase in patients with acute lymphoblastic leukemia and T cell non-Hodgkin lymphoma].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhiTreatment response in enteropathy associated T-cell lymphoma; survival in a large multicenter cohort.
American journal of hematologyAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Incidence of Hypertension During Induction Therapy in Children with Acute Lymphoblastic Leukemia.
- [Research Progress in ALK+/- Anaplastic Large Cell Lymphoma--Review].
- Flaccid Lower Limb Paraparesis Despite Infiltration of the Spinal Cord by a Secondary Central Nervous System T-cell Non-Hodgkin Lymphoma With Syringomyelia: A Case Report.
- Retrospective analysis of clinical characteristics, treatment outcomes and prognosis of patients with natural killer/T-cell lymphoma.
- Advances and updates in pediatric anaplastic large cell lymphoma.
- Case Report: A case of jejunal T-cell non-Hodgkin lymphoma with secondary bone involvement presenting as gastrointestinal perforation.
- Case Report: diffuse entire gastrointestinal tract involvement of ALK-positive anaplastic large cell lymphoma harboring JAK-STAT pathway mutations in an adolescent with leukemoid reaction.
- Anaplastic Lymphoma Kinase (ALK)-Positive Anaplastic Large Cell Lymphoma Presenting as an Axillary Breast Abscess in a Young Woman: A Case Report.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:171918(Orphanet)
- MONDO:0015760(MONDO)
- GARD:20133(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Q7667896(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
