Raras
Buscar doenças, sintomas, genes...
Doença de Marchiafava-Bignami
ORPHA:221074CID-10 · G37.1CID-11 · 8A46DOENÇA RARA

A Doença de Marchiafava-Bignami é definida por uma desmielinização típica do corpo caloso (que é o desgaste da camada protetora dos nervos que ligam os dois lados do cérebro). A doença parece afetar mais frequentemente pessoas com alcoolismo grave e de longa data, na meia-idade ou em idade mais avançada. Os primeiros sintomas podem incluir depressão, paranoia, psicose ou demência. Convulsões são comuns, e fraqueza de um lado do corpo (hemiparesia), dificuldade para falar (afasia), movimentos incomuns e falta de coordenação (ataxia) podem, às vezes, evoluir para coma e/ou morte. A causa da doença de Marchiafava-Bignami, incluindo o possível papel da deficiência nutricional, ainda é desconhecida. Já foram relatados casos de melhora e recuperação em algumas pessoas. O tratamento foca no apoio nutricional e na reabilitação do alcoolismo.

Mantido por Agente Raras·Colaborar como especialista →

Introdução

O que você precisa saber de cara

📋

A Doença de Marchiafava-Bignami é definida por uma desmielinização típica do corpo caloso (que é o desgaste da camada protetora dos nervos que ligam os dois lados do cérebro). A doença parece afetar mais frequentemente pessoas com alcoolismo grave e de longa data, na meia-idade ou em idade mais avançada. Os primeiros sintomas podem incluir depressão, paranoia, psicose ou demência. Convulsões são comuns, e fraqueza de um lado do corpo (hemiparesia), dificuldade para falar (afasia), movimentos incomuns e falta de coordenação (ataxia) podem, às vezes, evoluir para coma e/ou morte. A causa da doença de Marchiafava-Bignami, incluindo o possível papel da deficiência nutricional, ainda é desconhecida. Já foram relatados casos de melhora e recuperação em algumas pessoas. O tratamento foca no apoio nutricional e na reabilitação do alcoolismo.

Publicações científicas
322 artigos
Último publicado: 2026

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
<1 / 1 000 000
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Casos conhecidos
250
pacientes catalogados
Início
Adult
🏥
SUS: Cobertura mínimaScore: 15%
CID-10: G37.1
🇧🇷Dados SUS / DATASUS
PROCEDIMENTOS SIGTAP (2)
0202010694
Sequenciamento completo do exoma (WES)genetic_test
0301070040
Atendimento em reabilitação — doenças rarasrehabilitation
Você se identifica com essa condição?
O Raras está aqui pra te apoiar — com ou sem diagnóstico

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🧠
Neurológico
13 sintomas
👁️
Olhos
2 sintomas
🫘
Rins
2 sintomas
🫃
Digestivo
1 sintomas
😀
Face
1 sintomas

+ 31 sintomas em outras categorias

Características mais comuns

90%prev.
Morfologia anormal do corpo caloso
Muito frequente (99-80%)
90%prev.
Baixos níveis de vitamina B1
Muito frequente (99-80%)
90%prev.
Desnutrição
Muito frequente (99-80%)
90%prev.
Alcoolismo
Muito frequente (99-80%)
55%prev.
Disartria
Frequente (79-30%)
55%prev.
Distúrbio da marcha
Frequente (79-30%)
50sintomas
Muito frequente (4)
Frequente (11)
Ocasional (34)
Muito raro (1)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 50 características clínicas mais associadas, ordenadas por frequência.

Morfologia anormal do corpo calosoAbnormal corpus callosum morphology
Muito frequente (99-80%)90%
Baixos níveis de vitamina B1Low levels of vitamin B1
Muito frequente (99-80%)90%
DesnutriçãoMalnutrition
Muito frequente (99-80%)90%
AlcoolismoAlcoholism
Muito frequente (99-80%)90%
DisartriaDysarthria
Frequente (79-30%)55%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico322PubMed
Últimos 10 anos134publicações
Pico202419 papers
Linha do tempo
2026Hoje · 2026📈 2024Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Doença de Marchiafava-Bignami

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

Pesquisa e ensaios clínicos

Nenhum ensaio clínico registrado para esta condição.

🧪 Está conduzindo uma pesquisa?
Divulgue para pacientes e familiares que acompanham esta doença.
Divulgar pesquisa →

Publicações mais relevantes

Timeline de publicações
131 papers (10 anos)
#1

Marchiafava-Bignami disease mimicking acute corpus callosum infarction associated with chronic shochu consumption.

Surgical neurology international2026

Marchiafava-Bignami disease (MBD) is a rare alcohol-related disorder that predominantly affects the corpus callosum. Because MBD frequently demonstrates diffusion restriction on magnetic resonance imaging (MRI), it can closely mimic acute ischemic stroke (AIS), posing a diagnostic challenge in image-driven acute stroke evaluation. Early recognition is crucial, as timely thiamine therapy may result in complete clinical and radiologic recovery. A 38-year-old man with long-standing daily consumption of shochu, a Japanese distilled spirit, developed vertigo and vomiting on awakening, followed by mild right lower extremity weakness on day 5. MRI performed at a local clinic on day 6 revealed a diffusion-restricted lesion confined to the splenium of the corpus callosum, and corpus callosum infarction was initially suspected. On admission, the patient was fully conscious and exhibited horizontal gaze-evoked nystagmus with very mild right-sided weakness. MRI identified a splenial lesion of the corpus callosum exhibiting high signal intensity on diffusion-weighted imaging with corresponding low apparent diffusion coefficient values, accompanied by mild hyperintensity on T2-weighted and fluid-attenuated inversion recovery images. Given the patient's young age, absence of vascular risk factors, and the splenial distribution of the lesion, AIS was considered unlikely. Following consultation with a neurologist, MBD was suspected based on the patient's history of chronic alcohol consumption, and intravenous vitamin supplementation, including thiamine, was initiated. Neurological symptoms improved rapidly, and follow-up MRI on hospital day 8 demonstrated complete resolution of the splenial lesion. The patient was discharged without neurological sequelae on hospital day 10. A diffusion-restricted splenial lesion in patients with a history of chronic alcohol consumption and without vascular risk factors should prompt consideration of MBD rather than a reflexive diagnosis of AIS. Careful integration of imaging findings with clinical context is essential for identifying reversible stroke mimics and ensuring timely, appropriate treatment.

#2

Marchiafava-Bignami Disease with Hyperperfusion on Arterial Spin Labeling and Complete Recovery.

Neurology India2026 Jan 01

Marchiafava-Bignami disease (MBD) is a rare demyelinating disease, which mostly diagnosed among alcoholics. Previous studies on cerebral perfusion of patients with MBD mostly found hypoperfusion of corpus callosum and extra-callosal lesions. Nevertheless, hyperperfusion of corpus callosum in MBD has rarely been described.The aim of this study was to report a case of MBD with hyperperfusion on arterial spin labeling and completely recovered. We described a case of MBD with hyperperfusion in the corpus callosum on arterial spin labeling perfusion magnetic resonance imaging, presented with altered mental state. This MBD patient eventually achieved a complete recovery. We suppose that the hyperperfusion of corpus callosum in this patient may be associated with the vasodilation caused by the inflammatory response in the lesions. Future researches are needed to confirm our finding.

#3

Marchiafava-Bignami Disease and Pellagra in a Chronic Alcohol User: A Reversible Case of Cognitive Impairment.

Cureus2026 Jan

Marchiafava-Bignami disease (MBD) is a rare complication of chronic alcoholism characterized by demyelination of the corpus callosum. Pellagra, resulting from niacin (vitamin B3) deficiency, typically presents with dermatitis, diarrhea, and dementia. Both MBD and pellagra are often associated with severe nutritional deficiencies. We describe the case of a 56-year-old man with alcohol use disorder admitted after a syncopal episode, presenting with disorientation, apathy, and photosensitive desquamative lesions on sun-exposed skin. Brain MRI revealed T2 hyperintensity in the splenium and body of the corpus callosum, compatible with subacute MBS. Laboratory tests confirmed niacin deficiency, establishing concomitant pellagra. The patient received B-complex vitamin supplementation and was maintained in alcohol abstinence. His cognitive and dermatologic condition improved markedly, with near-complete recovery after six months. This case underlines the importance of recognizing nutritional deficiencies in alcohol-related neuropsychiatric presentations.

#4

Acute Marchiafava-Bignami Disease Linked to Tea and Toast Diet: A Case Report.

Acta neurologica Taiwanica2026 Jan 01

Marchiafava-Bignami disease (MBD) is a rare demyelinating disorder primarily associated with chronic alcoholism. We present a case of a nonalcoholic patient who developed acute cognitive decline secondary to severe dietary deficiency. Magnetic resonance imaging (MRI) demonstrated an isolated, symmetric lesion in the central corpus callosum, differentiating MBD from acute infarction. Rapid improvement followed Vitamin B supplementation, emphasizing the need for early recognition and treatment. This case expands the clinical spectrum of MBD and underscores the crucial role of MRI in diagnosis and prognosis.

#5

Initially Normal MRI, Delayed Splenial Lesion in Marchiafava-Bignami Disease.

Clinical case reports2026 Feb

Marchiafava-Bignami disease (MBD) may show normal findings on early MRI. In patients with alcohol use disorder or risk of thiamine deficiency, repeat imaging is important because splenial lesions can develop later. Recognizing this pattern is key to avoiding delayed diagnosis.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC272 artigos no totalmostrando 132

2026

Marchiafava-Bignami disease mimicking acute corpus callosum infarction associated with chronic shochu consumption.

Surgical neurology international
2026

Marchiafava-Bignami Disease and Pellagra in a Chronic Alcohol User: A Reversible Case of Cognitive Impairment.

Cureus
2026

Acute Marchiafava-Bignami Disease Linked to Tea and Toast Diet: A Case Report.

Acta neurologica Taiwanica
2026

Initially Normal MRI, Delayed Splenial Lesion in Marchiafava-Bignami Disease.

Clinical case reports
2026

Marchiafava-Bignami Disease with Hyperperfusion on Arterial Spin Labeling and Complete Recovery.

Neurology India
2025

[Ettore Marchiafava, A Roman Neurologist, and Marchiafava-Bignami Disease (MBD)].

Brain and nerve = Shinkei kenkyu no shinpo
2025

Entire corpus callosum and diffuse white matter involvement in acute Marchiafava-Bignami disease.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2025

Marchiafava-Bignami disease: A rare entity in chronic alcoholic with a poor prognosis.

Journal of family medicine and primary care
2025

Unraveling Dual Cognitive Disorders: A Case Report and Literature Review on Marchiafava-Bignami Disease and Possible Alzheimer's Disease.

Diseases (Basel, Switzerland)
2025

Marchiafava-Bignami Disease.

Neurology India
2025

Antemortem radiologic and histopathologic presentation of Marchiafava-Bignami disease.

Journal of neuropathology and experimental neurology
2025

A Rare Case of Marchiafava-Bignami Disease With Reversible Splenial Lesion.

Cureus
2025

A fatal case of acute Marchiafava-Bignami disease complicated by acute abdomen- a case report.

International journal of emergency medicine
2025

Co-occurrence of radiological signs of Marchiafava-Bignami disease and alcohol-related cerebellar degeneration.

Dementia &amp; neuropsychologia
2025

Alcohol and alcoholism associated neurological disorders: Current updates in a global perspective and recent recommendations.

World journal of experimental medicine
2025

Marchiafava-Bignami disease post-bariatric surgery: A case report and review of similar cases.

Neurosciences (Riyadh, Saudi Arabia)
2024

An Atypical Case of Marchiafava-Bignami Disease in a Young Chronic Alcoholic: Challenges in Diagnosis and Prognosis.

Cureus
2024

Marchiafava-Bignami Type A Disease: A Rare Neurological Manifestation in Oropharyngeal Cancer.

Cureus
2024

Marchiafava-Bignami Disease: A Case Report of a Reversible Cause of Dementia.

Cureus
2024

Marchiafava-Bignami Disease in a Postoperative Non-alcoholic Patient.

Cureus
2025

Marchiafava-Bignami disease with typical imaging findings: A case report.

Radiology case reports
2024

Relationship between alcohol consumption and cognitive impairment in the adult population over 60 years of age: A systematic review.

Revista Colombiana de psiquiatria
2024

Clinical analysis of Marchiafava-Bignami disease.

BMC neurology
2024

Marchiafava Bignami disease presenting as a cerebrovascular accident.

The American journal of emergency medicine
2024

Exploring Marchiafava-Bignami Disease: A Rare Presentation in a Young Pregnant Female.

Cureus
2024

Marchiafava-Bignami Disease in a Patient With Polysubstance Use Disorder.

Cureus
2024

Acute alcohol intoxication presenting acquired lesion of the corpus callosum in a young healthy woman: A case of possible Marchiafava-Bignami disease.

Acute medicine &amp; surgery
2024

Detection of Marchiafava Bignami disease using distinct deep learning techniques in medical diagnostics.

BMC medical imaging
2024

Marchiafava-Bignami disease: Prompt diagnosis made by magnetic resonance brain imaging.

Clinical case reports
2024

COVID-19-induced acute loss of consciousness in Marchiafava-Bignami disease: a case report.

The Journal of international medical research
2024

Oromandibular Dystonia After Low-Dose Olanzapine Treatment in a Patient With Marchiafava-Bignami Disease With Demyelinating Lesions in the Corpus Callosum: A Case Report.

Cureus
2024

Marchiafava-Bignami disease: why not Marchiafava-Bignami-Carducci disease?

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2024

Hand knob sign in Marchiafava-Bignami disease and Wernicke's encephalopathy.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2023

Clinico-radiologic subtypes and therapeutic observation of acute Marchiafava-Bignami disease.

Scientific reports
2023

Reversible hyperintensity in middle cerebellar peduncles. An infrequent finding in Marchiafava-Bignami disease.

Revista de neurologia
2023

Marchiafava-Bignami Disease in a Patient with Anorexia Nervosa.

Balkan medical journal
2023

A patient with Marchiafava-Bignami disease type A transported by ambulance with impaired consciousness and malnutrition was successfully treated after early diagnosis by MRI.

Journal of general and family medicine
2024

Marchiafava-Bignami disease(MBD) involving bilateral handknob area: neuroimages.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2023

Marchiafava-Bignami disease: Case presentation and radiological imaging.

Radiology case reports
2023

Risk factors and dynamic nomogram for unfavorable prognosis of Marchiafava-Bignami disease.

Annals of clinical and translational neurology
2024

Analysis of 21 Patients With Alcoholic Marchiafava-Bignami Disease in Chongqing, China.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
2023

Diagnosis and Management of Marchiafava-Bignami Disease, a Rare Neurological Complication of Long-term Alcohol Abuse.

Discoveries (Craiova, Romania)
2023

Marchiafava-Bignami Disease: A Rare Association With Dysdiadochokinesia and Ataxic Gait.

Cureus
2023

An Acute Presentation of Marchiafava-Bignami Disease.

Annals of neurology
2023

From Chronic Alcohol Consumption to Coma: Report of an Uncommon Cause.

Cureus
2023

Mild Encephalitis/Encephalopathy with a Reversible Lesion in The Splenium.

Noro psikiyatri arsivi
2023

Marchiafava-Bignami Disease: Report of a Subacute Case.

Cureus
2023

From Mild Gait Difficulties to a Sudden Coma: A Rare Case of Marchiafava-Bignami Disease.

Topics in magnetic resonance imaging : TMRI
2022

Clinical Presentation and Radiological Findings in Marchiafava-Bignami Disease.

Annals of Indian Academy of Neurology
2022

Marchiafava Bignami Disease: A Rare Neurological Complication of Long-Term Alcohol Abuse.

Cureus
2023

Acute necrosis of the corpus callosum.

European journal of internal medicine
2022

MRI Spectrum of Toxic Encephalopathy-An Institutional Experience.

Neurology India
2022

Intermediate Syndrome and Marchiafava-Bignami Syndrome: Double Trouble in Weaning Off.

Cureus
2022

Amantadine as a Potential Treatment for Marchiafava-Bignami Disease: Case Reports and a Possible Mechanism.

Case reports in neurological medicine
2022

Marchiafava-Bignami disease presenting as reversible coma.

BMJ case reports
2022

Marchiafava-Bignami disease concurrent with intracerebral hemorrhage: a case description.

Quantitative imaging in medicine and surgery
2022

Magnetic resonance spectroscopy and gadolinium enhancement assist in the diagnosis of nonalcoholic Marchiafava-Bignami disease with necrosis lesions: a case description.

Quantitative imaging in medicine and surgery
2021

Classical Imaging Finding in Marchiafava Bignami Disease.

Neurology India
2020

Neuropsychological Tests for Patients with Marchiafava-Bignami Disease: A Case Report.

Psychiatry investigation
2021

A rare MRI finding in a patient with Marchiafava-Bignami disease.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2021

Marchiafava-Bignami disease in a patient with schizophrenia and alcohol use disorder.

Actas espanolas de psiquiatria
2021

Disconnected Motor Intention and Spatial Attention in a Case of Probable Marchiafava-Bignami Disease.

Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology
2021

Marchiafava-Bignami Disease: A Case of Success.

The primary care companion for CNS disorders
2021

Co-occurrence of Marchiafava-Bignami Disease and Alcoholic Polyneuropathy in Chronic Alcoholic Patient Who Had Past History of Wernicke Encephalopathy: a Case Report.

Brain &amp; NeuroRehabilitation
2021

A Case of Cortical Involvement in Marchiafava-Bignami Disease Accompanying Wernicke's Encephalopathy.

Journal of clinical neurology (Seoul, Korea)
2021

A rare neurological manifestation of a malnourished alcohol-dependent acute pancreatitis patient with Marchiafava-Bignami disease.

Gastroenterology report
2021

[Mild Encephalopathy with Reversible Splenial Lesion(MERS)].

No shinkei geka. Neurological surgery
2020

Rare case of Marchiafava-Bignami disease due to thiamine deficiency and malnutrition.

BMJ case reports
2020

Marchiafava-Bignami Disease Associated with Spinal Involvement.

Case reports in neurological medicine
2021

Marchiafava-Bignami disease-like corpus callosum lesions due to moyamoya disease.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2021

Depression preceding Marchiafava-Bignami disease.

The Australian and New Zealand journal of psychiatry
2021

Diverse MRI findings and clinical outcomes of acute Marchiafava-Bignami disease.

Acta radiologica (Stockholm, Sweden : 1987)
2020

Simultaneous acute Marchiafava-Bignami disease and posterior reversible encephalopathy syndrome: a case almost misdiagnosed.

Quantitative imaging in medicine and surgery
2020

Reversible lesion in the splenium of the corpus callosum in a patient with chronic alcoholism.

Journal of general and family medicine
2020

Marchiafava-Bignami Disease: Two Chronologically Distinct Stages in the Same Patient.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
2021

Comprehensive neuropsychological findings in a case of Marchiafava-Bignami disease.

The Clinical neuropsychologist
2020

Marchiafava-Bignami disease: Report of three cases.

Ideggyogyaszati szemle
2020

Neuroimaging of Multiple Sclerosis Mimics.

Neurologic clinics
2019

Marchiafava-Bignami Disease in a Patient with No Alcohol Abuse.

Neurology India
2019

Marchiafava-Bignami disease with haemophagocytic lymphohistiocytosis as a postoperative complication of cardiac surgery.

BMJ case reports
2019

Intermittent alien hand syndrome caused by Marchiafava-Bignami disease: A case report.

Medicine
2019

"CHOICES": An acronym to aid in delineating potential causes of non-metabolic, non-infectious acute toxic leukoencephalopathy.

European journal of radiology open
2019

Clinical and neuroradiological features of 15 patients diagnosed with Marchiafava-Bignami disease.

Chinese medical journal
2019

Antemortem histopathology and imaging findings in a case of Marchiafava-Bignami disease.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
2019

Overreligious beliefs with neuropsychiatric manifestations in a young lady-Rule out Marchiafava-Bignami disease.

Medical journal, Armed Forces India
2019

Reversible MR Findings in Marchiafava-Bignami Disease.

Case reports in neurological medicine
2019

Refractory Nonconvulsive Status Epilepticus with Favorable Outcome in a Patient with Marchiafava-Bignami Disease.

Journal of clinical neurology (Seoul, Korea)
2019

Gadolinium Enhancement May Indicate a Condition at Risk of Developing Necrosis in Marchiafava-Bignami Disease: A Case Report and Literature Review.

Frontiers in human neuroscience
2019

MR imaging in the diagnosis of Marchiafava-Bignami syndrome.

Neurology India
2018

Left hemispatial neglect with a splenial lesion.

Neurocase
2019

Bilateral middle cerebellar peduncles involvement a malnourished man with Marchiafava-Bignami disease.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2018

A Case of Nonalcoholic Marchiafava-Bignami Disease with Left-Right Differential Agraphia of Chinese Characters.

Case reports in neurology
2018

Marchiafava-Bignami Disease Presenting as Acute Psychosis.

Indian journal of psychological medicine
2018

Rapidly Resolving Nonalcoholic Marchiafava-Bignami Disease in the Setting of Malnourishment After Gastric Bypass Surgery.

Journal of investigative medicine high impact case reports
2019

Reversible "ears of the lynx" sign in Marchiafava-Bignami disease.

Acta neurologica Belgica
2018

Marchiafava-Bignami Disease with Cortical Involvement.

Clinical laboratory
2018

Unilateral Apraxic Agraphia without Ideomotor Apraxia from a callosal lesion in a patient with Marchiafava-Bignami disease.

Neurocase
2018

Simultaneous acute Marchiafava-Bignami disease and central pontine myelinolysis: A case report of a challenging diagnosis.

Medicine
2018

Clinical and radiological features of Marchiafava-Bignami disease.

Medicine
2018

Fatal serotonin syndrome in a patient with Marchiafava-Bignami disease: Combined neurological and psychiatric emergency.

Neurologia i neurochirurgia polska
2017

Marchiafava Bignami disease.

Neurology India
2017

Demyelinating diseases as a result of cerebral edema?

Medical hypotheses
2017

Marchiafava-Bignami's Disease, as Etiologic Diagnosis of Athetosis.

Annals of neurosciences
2017

A rare case of Marchiafava-Bignami disease: Extracallosal lesions involving bilateral medipeduncle.

Neurology India
2017

Marchiafava-Bignami Disease: A Rare Clinical Dilemma.

The Journal of the Association of Physicians of India
2017

Clinical Reasoning: Corpus callosum lesion with multiple strokes.

Neurology
2017

Thiamine deficiency, oxidative metabolic pathways and ethanol-induced neurotoxicity: how poor nutrition contributes to the alcoholic syndrome, as Marchiafava-Bignami disease.

European journal of clinical nutrition
2017

Neuroimaging of chronic alcohol misuse.

Journal of medical imaging and radiation oncology
2016

Partial interhemispheric disconnection syndrome (P-IHDS) secondary to Marchiafava-Bignami disease type B (MBD-B).

BMJ case reports
2016

Altered Sensorium in a Young Male: Marchiafava Bignami Disease Revisited.

The Journal of the Association of Physicians of India
2016

Marchiafava-Bignami and Alcohol Related Acute Polyneuropathy: The Cooccurrence of Two Rare Entities.

Case reports in neurological medicine
2016

Mutism Caused by Severe Demyelination in a Patient With Marchiafava-Bignami Disease.

The Journal of emergency medicine
2016

Marchiafava-Bignami disease in chronic alcoholic patient.

Radiology case reports
2017

Vegetarian diet and excessive tea consumption: a dangerous association?

Metabolic brain disease
2015

Altered sensorium in a chronic alcoholic: pancreatic encephalopathy, Wernicke's encephalopathy or Marchiafava Biganami disease?

Tropical gastroenterology : official journal of the Digestive Diseases Foundation
2016

[Marchiafava-Bignami disease (Case-report)].

Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology
2016

Marchiafava-Bignami Disease with frontal cortex involvement and late onset, long-lasting psychiatric symptoms: a case report.

Rivista di psichiatria
2016

Marchiafava: Bignami Disease Treated with Parenteral Thiamine.

Indian journal of psychological medicine
2016

[A case of Marchiafava-Bignami disease suggesting vasogenic edema].

Rinsho shinkeigaku = Clinical neurology
2016

Marchiafava-Bignami disease in an AIDS patient.

Arquivos de neuro-psiquiatria
2015

Marchiafava-Bignami disease with asymmetric extracallosal lesions.

Archives of medical science : AMS
2015

Chronic stage of Marchiafava-Bignami disease.

Arquivos de neuro-psiquiatria
2015

Neurological and psychiatric findings of marchiafava-bignami disease in a nonalcoholic diabetic patient with high blood glucose levels.

The Journal of neuropsychiatry and clinical neurosciences
2015

Neurologic Manifestations of Chronic Liver Disease and Liver Cirrhosis.

Current problems in diagnostic radiology
2015

[Investigating the symptoms of white matter disorders].

Brain and nerve = Shinkei kenkyu no shinpo
2015

Marchiafava-Bignami disease as a cause of visual hallucinations.

Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
2015

Marchiafava-Bignami disease with rare etiology: A case report.

Experimental and therapeutic medicine
2015

Teaching NeuroImages: Reversible widespread brain MRI lesions in Marchiafava-Bignami disease.

Neurology
2016

Marchiafava-Bignami disease triggered by poorly controlled diabetes mellitus.

Neurologia (Barcelona, Spain)
2015

Marchiafava-Bignami disease in a trauma patient.

Journal of emergencies, trauma, and shock
2014

[Relationship between callosal lesions and cerebral microhemorrhage in Marchiafava-Bignami disease].

Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies &amp; drug dependence
2015

Spinal anesthesia in a patient with Marchiafava-Bignami disease.

Canadian journal of anaesthesia = Journal canadien d'anesthesie
Ver todos os 272 no EuropePMC

Associações

Organizações que acompanham esta doença — pra ter apoio e orientação

Ainda não temos associações cadastradas para Doença de Marchiafava-Bignami.

É de uma associação que acompanha esta doença? Fale com a gente →

Comunidades

Grupos ativos de quem convive com esta doença aqui no Raras

Ainda não existe comunidade no Raras para Doença de Marchiafava-Bignami

Pacientes, familiares e cuidadores se organizam em comunidades pra compartilhar experiências, fazer perguntas e se apoiar. Você pode ser o primeiro.

Tire suas dúvidas

Perguntas, dicas e experiências compartilhadas aqui na página

Participe da discussão

Faça login para postar dúvidas, compartilhar experiências e interagir com especialistas.

Fazer login

Doenças relacionadas

Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico

Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Marchiafava-Bignami disease mimicking acute corpus callosum infarction associated with chronic shochu consumption.
    Surgical neurology international· 2026· PMID 41783222mais citado
  2. Marchiafava-Bignami Disease with Hyperperfusion on Arterial Spin Labeling and Complete Recovery.
    Neurology India· 2026· PMID 41510871mais citado
  3. Marchiafava-Bignami Disease and Pellagra in a Chronic Alcohol User: A Reversible Case of Cognitive Impairment.
    Cureus· 2026· PMID 41732620mais citado
  4. Acute Marchiafava-Bignami Disease Linked to Tea and Toast Diet: A Case Report.
    Acta neurologica Taiwanica· 2026· PMID 41609123mais citado
  5. Initially Normal MRI, Delayed Splenial Lesion in Marchiafava-Bignami Disease.
    Clinical case reports· 2026· PMID 41584392mais citado
  6. Case Report: Marchiafava-Bignami disease: anti-parietal cell antibodies as a potential etiological factor in a novel case presentation.
    Front Mol Biosci· 2026· PMID 41930251recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:221074(Orphanet)
  2. MONDO:0016370(MONDO)
  3. GARD:6971(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Q94796(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Doença de Marchiafava-Bignami
Compêndio · Raras BR

Doença de Marchiafava-Bignami

ORPHA:221074 · MONDO:0016370
Prevalência
<1 / 1 000 000
Casos
250 casos conhecidos
CID-10
G37.1 · Desmielinização central do corpo caloso
CID-11
Início
Adult
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C0238265
EuropePMC
Wikidata
Papers 10a
DiscussaoAtiva

Nenhuma novidade ainda. O agente esta monitorando.

0membros
0novidades