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Ependimoma anaplásico
ORPHA:251646CID-10 · C71.9CID-11 · 2A00.0YDOENÇA RARA

Ependimoma anaplásico é um tipo raro e agressivo de ependimoma que geralmente surge na parte superior do cérebro de crianças e adultos jovens, e que se manifesta com sintomas variados, incluindo dores de cabeça, náuseas, problemas de visão, perda de memória e dificuldade para andar.

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Introdução

O que você precisa saber de cara

📋

Ependimoma anaplásico é um tipo raro e agressivo de ependimoma que geralmente surge na parte superior do cérebro de crianças e adultos jovens, e que se manifesta com sintomas variados, incluindo dores de cabeça, náuseas, problemas de visão, perda de memória e dificuldade para andar.

Pesquisas ativas
5 ensaios
91 total registrados no ClinicalTrials.gov
Publicações científicas
410 artigos
Último publicado: 2026 Mar 17

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
<1 / 1 000 000
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.04
United States
Início
Adolescent
+ adult, childhood
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: C71.9
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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Características mais comuns

Início na idade adulta
1sintomas
Sem dados (1)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 1 características clínicas mais associadas, ordenadas por frequência.

Início na idade adultaAdult onset

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico410PubMed
Últimos 10 anos198publicações
Pico201832 papers
Linha do tempo
2026Hoje · 2026🧪 1966Primeiro ensaio clínico📈 2018Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

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Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

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Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
3Fase 31
2Fase 27
1Fase 19
·Pré-clínico3
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 20 ensaios
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Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Ependimoma anaplásico

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Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

3 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

Outros ensaios clínicos

91 ensaios clínicos encontrados, 5 ativos.

Distribuição por fase
NCT04978727 · A Pilot Study of SurVaxM in Children Progressive or Relapsed…Ativo
PHASE1
NCT01096368 · Maintenance Chemotherapy or Observation Following Induction …Ativo
PHASE3
NCT01165632 · Fluorine F 18 Fluorodopa-Labeled PET Scan in Planning Surger…Concluído
EARLY_PHASE1
NCT01295944 · Carboplatin and Bevacizumab for Recurrent EpendymomaConcluído
PHASE2
NCT02186509 · Alisertib and Fractionated Stereotactic Radiosurgery in Trea…Concluído
PHASE1
NCT02722512 · Trial of Heat Shock Protein Peptide Complex-96 (HSPPC-96) Va…Encerrado
PHASE1
NCT02101905 · Lapatinib Ditosylate Before Surgery in Treating Patients Wit…Concluído
PHASE1
NCT04521946 · Chemotherapy and Donor Stem Transplant for the Treatment of …Cancelado
PHASE1
NCT03434262 · SJDAWN: St. Jude Children's Research Hospital Phase 1 Study …Concluído
PHASE1
NCT01721577 · Phase I/II Trial of AXL1717 in the Treatment of Recurrent Ma…Encerrado
PHASE1, PHASE2
NCT03727841 · Marizomib for Recurrent Low-Grade and Anaplastic Supratentor…Encerrado
PHASE2
NCT00003479 · Antineoplaston Therapy in Treating Patients With EpendymomaEncerrado
PHASE2
NCT01478321 · Efficacy of Hypofractionated XRT w/Bev. + Temozolomide for R…Encerrado
PHASE2
NCT01836549 · Imetelstat Sodium in Treating Younger Patients With Recurren…Encerrado
PHASE2
NCT01234805 · Yoga Therapy in Treating Patients With Malignant Brain Tumor…Encerrado
NA
NCT01234740 · Bafetinib in Treating Patients With Recurrent High-Grade Gli…Concluído
PHASE1
NCT02194452 · Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) …Cancelado
NA
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
198 papers (10 anos)
#1

Thoracic tanycytic ependymoma with anaplastic progression after subtotal resection and repeated radiotherapy: A 17-year follow-up case report.

Surgical neurology international2026

Tanycytic ependymomas (TEs) are rare spindle-cell variants of spinal ependymomas. They are classified as central nervous system World Health Organization grade II, and they usually behave like ordinary spinal ependymomas especially following gross total resection (GTR). A 43-year-old male presented with a progressive paraparesis and sensory level at T4 (pain/ temperature loss). The magnetic resonance imaging showed an intradural intramedullary tumor extending from Th2 to Th5. Only a subtotal resection was performed as a central portion was tightly adherent to the spinal cord itself. Histology revealed a predominantly grade II TE; the main component showed a low proliferative index, whereas the anaplastic focus had a markedly elevated index. Despite craniospinal tomotherapy (36 Gy), tumor recurred 6 years 7 months later. Local tomotherapy was repeated 3 times (41.4, 40, and 30 Gy), but each treatment produced only transient shrinkage followed by regrowth at shorter intervals. Further irradiation was contraindicated due to cumulative dose constraints. Seventeen years after the first surgery, rapid enlargement over 3 months caused paraplegia and bladder-bowel dysfunction. Reoperation achieved GTR, and at this point the pathology showed a diffuse anaplastic ependymoma; the MR 6 months later showed no tumor recurrence. Although TE is usually indolent, it can harbor an anaplastic subclone and progress to malignancy after subtotal resection. Long-term surveillance and early reoperation when regrowth is first observed should be considered and is likely due to the development of anaplastic features.

#2

Nivolumab-Associated Autoimmune Encephalopathy in a Child With Multiply Relapsed Anaplastic Ependymoma.

Pediatric blood &amp; cancer2026 Mar 17
#3

Recurrent pediatric posterior fossa anaplastic ependymoma managed with multiple resections: illustrative case.

Journal of neurosurgery. Case lessons2026 Jan 19

Maximal safe resection of ependymoma should be attempted whenever feasible. To clarify the potential and limits of surgery in recurrent pediatric ependymoma, the authors report a posterior fossa anaplastic ependymoma in a boy who ultimately underwent 18 resections. After initial multimodal therapy, resection with no detectable contrast-enhancing tumor on imaging and/or no visually apparent residual tumor intraoperatively was achieved at each operation from the 5th through the 16th, yielding 8 years 8 months of surgery-only local control. At the 17th surgery, a small remnant invading the right dorsolateral medulla was unavoidable; 7 months later, an 18th procedure achieved only partial resection and was followed by reirradiation. Recurrences arose from varying ependymal sites along the floor of the fourth ventricle rather than a single fixed locus, and a normal-appearing ependymal lining re-formed after sequential resections. Across all 18 operations, no infectious complications occurred. The tumor later progressed to circumferential brainstem involvement, and the patient died of respiratory failure 16 years 8 months after initial therapy. Repeated resections achieving no radiographic and intraoperative residual tumor may contribute to long-term survival in ependymoma; however, durable survival appears to depend on the persistence of locally resectable relapse. https://thejns.org/doi/10.3171/CASE25834.

#4

Clinical Features and Prognostic Indicators for Brainstem Ependymomas : A Population-Based Retrospective Surveillance, Epidemiology, and End Results Database Analysis.

Journal of Korean Neurosurgical Society2026 Mar

Ependymomas is a rare brain tumor. Accumulative evidence has revealed that there are differences between pediatric and adult patients. However, the clinical features and survival prognosis of pediatric and adult patients with brainstem ependymomas remain unclear. Pediatric and adult patients with brainstem ependymomas diagnosed between 2000 and 2021 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. The clinical characteristics (age, sex, race, tumor size treatment methods, etc.) of the included patients were reviewed, and the survival analysis was estimated via the Kaplan-Meier method. A total of 701 patients, including 269 pediatric patients and 432 adult patients, were identified. The median age of pediatric patients is 3.0 years old and the adult patients is 46.0 years old. Compared with adult brainstem ependymomas, pediatric patients showed a higher prevalence of anaplastic ependymoma, larger tumor size, and more frequent receipt of gross total resection (GTR), radiation, and chemotherapy (all P<0.001). Cox regression analysis identified that black race (P=0.032), and chemotherapy (P=0.048) are independent risk factors for pediatric brainstem ependymomas, and aging (P<0.001), male (P=0.034), and black race (P=0.002) for adult brainstem ependymomas. Survival analysis showed that GTR combined with radiation had significant overall survival advantage compared with other treatment regimens in both pediatric and adult cohorts (P=0.045 and P=0.034, respectively). This study comprehensively investigated the clinical features and survival outcomes of patients with brainstem ependymomas, and identified several independent prognostic variables. The best recommended treatment method was GTR combined with radiation.

#5

Characteristics and therapeutic profile of the patients with upper cervical spinal cord ependymoma from the medulla oblongata to C4: A cohort of 108 cases.

Clinical neurology and neurosurgery2025 Feb

Upper cervical spinal ependymomas (uCSE) is routinely identified as intramedullary ependymomas located from the oblongata medulla to C4 level. Our study aimed to report the outcomes and treatment profiles of uCSE from our cohort of uCSE patients. This retrospective observational study included 108 patients with upper cervical spinal ependymomas (uCSE) who underwent surgery at Huashan Hospital from 2008 to 2022. Demographic and clinical data were collected to identify risk factors may associated with post-operative spinal cord function, quality of life and respiratory function. The mean age of included patients was 44.30 ± 12.71 years old. The most common uCSE was ependymoma (103 of 108, 95.37 %), followed by subependymoma (3 of 108, 2.78 %) and anaplastic Ependymoma (2 of 108, 1.85 %). Age (P = 0.003), sex (P = 0.004), duration of symptoms (P = 0.010), pre-operative bladder functions (P = 0.012), post-operative pneumonia (P = 0.013) and Carbon Dioxide Retention (CDR) (P = 0.004) could independently correlate with Iiving quality of uCSE patients. Post-operative spinal cord function was associated with pneumonia immediately after operation (P = 0.017). In addition, post-operative pneumonia correlated with tumor location (P = 0.048), pre-operative McCormick scores (P = 0.008)/ motor functions (P = 0.022)/ NRS scores (P = 0.020), and tracheotomy immediately after operation (P < 0.001). Tracheotomy immediately after operation was associated with tumor location (P = 0.023), unsteady walking (P = 0.033), pre-operative NRS scores (P = 0.029), post-operative pneumonia (P < 0.001) and CDR (P < 0.001). Within uCSE patients, post-operative quality of life is associated with pre-operative spinal cord function and symptom duration, which emphasizing the importance of early intervention. Their post-operative respiratory dysfunctions also correlated with post-operative spinal cord function and quality of life.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC159 artigos no totalmostrando 196

2026

Nivolumab-Associated Autoimmune Encephalopathy in a Child With Multiply Relapsed Anaplastic Ependymoma.

Pediatric blood &amp; cancer
2026

Thoracic tanycytic ependymoma with anaplastic progression after subtotal resection and repeated radiotherapy: A 17-year follow-up case report.

Surgical neurology international
2026

Recurrent pediatric posterior fossa anaplastic ependymoma managed with multiple resections: illustrative case.

Journal of neurosurgery. Case lessons
2025

Extraspinal sacrococcygeal anaplastic ependymoma: A case report.

International journal of surgery case reports
2026

Clinical Features and Prognostic Indicators for Brainstem Ependymomas : A Population-Based Retrospective Surveillance, Epidemiology, and End Results Database Analysis.

Journal of Korean Neurosurgical Society
2025

Ascending Transtentorial Herniation: A Rare Complication of Posterior Cranial Fossa Tumors and Review of Literature.

Asian journal of neurosurgery
2025

Targeted Therapy with Dalpiciclib in a Pediatric Patient with Anaplastic Ependymoma: A Case Study and Literature Review.

Recent patents on anti-cancer drug discovery
2025

An anaplastic ependymoma with chondroid metaplasia after stereotactic radiosurgery: illustrative case.

Journal of neurosurgery. Case lessons
2024

Case Report: Clinical awareness about the effect of laser interstitial thermal therapy on pediatric high-grade brain tumors after radiotherapy.

Frontiers in surgery
2025

Characteristics and therapeutic profile of the patients with upper cervical spinal cord ependymoma from the medulla oblongata to C4: A cohort of 108 cases.

Clinical neurology and neurosurgery
2024

Pediatric skull base tumors: Clinical features and surgical outcomes; a single center retrospective study with a review of literature.

Brain &amp; spine
2024

Anaplastic Ependymoma and Atypical Refractory Longitudinal Expansive Transverse Myelitis Due to Immune Reaction After COVID-19 - A Case Discussion That Raises Many Unknown Questions About Covid-19.

Noro psikiyatri arsivi
2024

Anaplastic cortical ependymoma in 10 months girl: A case report.

International journal of surgery case reports
2024

Transcranial motor-evoked potentials disappear with pons transection.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2024

Adult supratentorial extraventricular anaplastic ependymoma with cerebrospinal fluid dissemination metastases: a case report.

Frontiers in neurology
2024

Imaging of Adult Malignant Soft Tissue Tumors of the Spinal Canal: A Guide for Spine Surgeons.

World neurosurgery
2024

Single-cell RNA sequencing of anaplastic ependymoma and H3K27M-mutant diffuse midline glioma.

BMC neurology
2024

Stereotactic radiosurgery for the treatment of a distant recurrence of ependymoma on the optic nerve: illustrative case.

Journal of neurosurgery. Case lessons
2024

A case of disseminated spinal astroblastoma harboring a MAMLD1::BEND2 fusion.

Neuropathology : official journal of the Japanese Society of Neuropathology
2023

Recurrent intracranial anaplastic ependymoma with late-onset giant scalp metastasis.

Clinical case reports
2023

C11orf95-RELA, YAP1-MAMLD1, and YAP1-FAM118B Fusion Negative Anaplastic Ependymoma with Lipogenic Differentiation.

Neurology India
2023

Supratentorial extra-axial anaplastic ependymoma: a rare case report.

Annals of medicine and surgery (2012)
2023

Dorsal cervical approach for recurrent intradural anaplastic ependymoma.

Neurosurgical focus: Video
2023

[Ependymoma in WHO Classification of Tumours 5th Edition].

No shinkei geka. Neurological surgery
2023

Combined cytotoxic and immune-stimulatory gene therapy for primary adult high-grade glioma: a phase 1, first-in-human trial.

The Lancet. Oncology
2023

Dry Field Technique and Ultrasonic Aspirator in Endoscopic Removal of a Hemorrhagic Intraventricular Tumor in a 2-Year-Old Girl.

World neurosurgery
2023

Prostate-Specific Membrane Antigen (PSMA) Expression in The Neovasculature of High Grade Gliomas (Histopathological and Immunohistochemical Study).

Asian Pacific journal of cancer prevention : APJCP
2023

Efficacy of the pedicle trapezius muscle flap for the multisurgical removal of pediatric posterior fossa anaplastic ependymoma.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2023

Recombinant polio-rhinovirus immunotherapy for recurrent paediatric high-grade glioma: a phase 1b trial.

The Lancet. Child &amp; adolescent health
2023

Primary spinal anaplastic ependymoma: A single-institute retrospective cohort and systematic review.

Frontiers in oncology
2023

High-grade neuroepithelial tumor with EP300::BCOR fusion and negative BCOR immunohistochemical expression: a case report.

Brain tumor pathology
2023

Spontaneous intracerebral haemorrhage secondary to 5-ALA-induced thrombocytopaenia in a paediatric patient: case report and literature review.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2023

Supratentorial tumor resembling anaplastic ependymoma in an adolescent.

Brain pathology (Zurich, Switzerland)
2022

The Positive Impact of a Chemotherapeutic Approach on Relapse Ependymoma or WHO Grade III Anaplastic Ependymoma: Report of a Rare Case.

Cureus
2023

A Nomogram for Prediction of Patients with Anaplastic Ependymoma in the Brain and Spinal Cord Survival.

Turkish neurosurgery
2022

Photodynamic therapy for malignant brain tumors in children and young adolescents.

Frontiers in oncology
2023

A cystic anaplastic ependymoma mimicking a pilocytic astrocytoma.

Radiology case reports
2022

Posterior Reversible Encephalopathy Syndrome Developing after Aggressive Posterior Fossa Tumor Surgery.

Asian journal of neurosurgery
2023

Unusual Case of Multilevel Spinal Anaplastic Ependymoma.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
2022

Oligomicrodontia in a Pediatric Cancer Survivor after Chemotherapy: A Case Report.

Healthcare (Basel, Switzerland)
2022

Supratentorial extra-axial RELA fusion-positive ependymoma misdiagnosed as meningioma by intraoperative histological and cytological examinations: a case report.

Journal of medical case reports
2022

Extra-Axial supratentorial anaplastic ependymoma: Unusual location of an aggressive tumor, A case report.

Indian journal of pathology &amp; microbiology
2022

Metronomic Cyclophosphamide With Cisplatin and Bevacizumab for Refractory Anaplastic Ependymoma: A Retrospective Study.

Anticancer research
2021

Management of intractable chronic cough during awake craniotomy: illustrative case.

Journal of neurosurgery. Case lessons
2022

Magnetic Resonance Imaging of Unusual Neoplasms Related to Foramen of Luschka: A Review for Differential Diagnosis.

The Indian journal of radiology &amp; imaging
2022

Diffusely infiltrating glioma with CREBBP-BCORL1 fusion showing overexpression of not only BCORL1 but BCOR: A case report.

Brain tumor pathology
2022

Epidemiological characteristics of central nervous system tumors in children: a 5-year review of 3180 cases from Beijing Tiantan Hospital.

Chinese neurosurgical journal
2022

Supratentorial ependymoma, zinc finger translocation-associated fusion positive, with extensive synaptophysin immunoreactivity arising from malignant transformation of clear cell ependymoma: A case report.

Surgical neurology international
2022

Clinical Profile and Outcomes of Primary Immunodeficiency and Malignancy in Childhood at a Tertiary Oncology Center in Developing Country.

Pediatric hematology and oncology
2021

Refined Temporal-to-Frontal Horn Shunt for Treatment of Trapped Temporal Horn After Surgery of Peri- or Intraventricular Tumor: A Case Series Study.

Frontiers in oncology
2021

An Overview of Intracranial Ependymomas in Adults.

Cancers
2022

Adult Posterior Fossa Anaplastic Ependymoma, Case Series and Literature Review.

World neurosurgery
2021

What Happens after Therapy? Quality of Life and Neurocognitive Functions of Children with Malignant Posterior Fossa Tumors after Adjuvant Therapy.

Neurology India
2022

Clinical-pathological study of 28 glial and mixed neuronal-glial tumors diagnosed within the first year of life.

Clinical neuropathology
2022

Severe Pneumonia Caused by Methicillin-Resistant Staphylococcus pseudintermedius in an Oncology Patient: Case Report and Literature Review.

Microbial drug resistance (Larchmont, N.Y.)
2022

Bicentric Treatment Outcomes After Proton Therapy for Nonmyxopapillary High-Grade Spinal Cord Ependymoma in Children.

International journal of radiation oncology, biology, physics
2021

Extra-Ventricular C11orf95-RELA Fusion Positive Anaplastic Ependymoma with Divergent Histological and Immunohistochemical Features: Report of a Rare Case.

Neurology India
2021

Pineal Anaplastic Ependymoma - A Rare Entity.

Neurology India
2021

Supratentorial extraventricular ependymoma presenting calvarial erosion: A report of 3 cases.

Radiology case reports
2021

Cytology of Extraneural Metastases of Nonhematolymphoid Primary Central Nervous System Tumors: Six Cases with Histopathological Correlation and Literature Update.

Acta cytologica
2021

Anaplastic myxopapillary ependymoma of the sacrum: A case report.

Surgical neurology international
2021

Epidemiology and Survival of Patients With Brainstem Gliomas: A Population-Based Study Using the SEER Database.

Frontiers in oncology
2022

PAX6 is frequently expressed in ependymal tumours and associated with prognostic relevant subgroups.

Journal of clinical pathology
2021

Differential expression of stem cell markers in proliferating cells in glioma.

Journal of cancer research and clinical oncology
2021

Nimotuzumab therapy in the treatment of pediatric central nervous system tumors: single-center experience.

Naunyn-Schmiedeberg's archives of pharmacology
2021

Ependymoma Presenting as a -Rim-Enhancing Lesion in the Brainstem.

Pediatric neurosurgery
2021

Image-Guided Robotic Radiosurgery for the Management of Spinal Ependymomas.

Frontiers in oncology
2021

Diffusion MRI in Evaluation of Pediatric Posterior Fossa Tumors.

Asian Pacific journal of cancer prevention : APJCP
2021

Mediastinal Anaplastic Ependymoma.

Journal of chest surgery
2021

The Spectrum of Underlying Diseases in Children with Torticollis.

Turkish neurosurgery
2021

High-grade neuroepithelial tumor with BCL6 corepressor-alteration presenting pathological and radiological calcification: A case report.

Pathology international
2021

RELA Fusion-Positive Ependymoma in a Child with Down Syndrome: A Case Report.

Pediatric neurosurgery
2021

Intracranial ependymomas: The role of advanced neuroimaging in diagnosis and management.

The neuroradiology journal
2021

Intracytoplasmic dot-like inclusions as cytopathologically useful findings of ependymoma: Case report of adolescent supratentorial anaplastic ependymoma with clear cell morphology.

Clinical case reports
2021

Grade III intradural extramedullary anaplastic ependymoma managed with near-complete resection and adjuvant radiotherapy: a case report.

Spinal cord series and cases
2020

[Visual fluorescence combined with laser spectroscopy in surgery for intramedullary spinal cord tumors].

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko
2021

Ependymoma with C11orf95-MAML2 fusion: presenting with granular cell and ganglion cell features.

Brain tumor pathology
2021

Cervicodorsal extramedullary anaplastic ependymoma with intracranial metastasis.

Neuro-Chirurgie
2021

Long-term outcomes of spinal ependymomas: an institutional experience of more than 60 cases.

Journal of neuro-oncology
2021

A phase II study of dose-dense temozolomide and lapatinib for recurrent low-grade and anaplastic supratentorial, infratentorial, and spinal cord ependymoma.

Neuro-oncology
2020

Ependymoma, NOS and anaplastic ependymoma incidence and survival in the United States varies widely by patient and clinical characteristics, 2000-2016.

Neuro-oncology practice
2021

The potentially therapeutic targets of pediatric anaplastic ependymoma by transcriptome profiling.

Neoplasma
2023

Fahr's disease associated with anaplastic ependymoma: a case report and review of the literature.

British journal of neurosurgery
2020

Comparison of Conventional, Diffusion, and Perfusion MRI Between Low-Grade and Anaplastic Extraventricular Ependymoma.

AJR. American journal of roentgenology
2020

RELA fusion-positive ependymoma accompanied by extensive desmoplasia: a case report.

Brain tumor pathology
2021

Recurring pediatric anaplastic ependymoma with rare peritoneal carcinomatosis: a case report and hypothesis of mechanism.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2020

Corrigendum to 'Anaplastic ependymoma metastases through a ventriculoperitoneal shunt' [Radiology Case Reports 15 (2020) 650-654].

Radiology case reports
2020

Extraneural metastatic anaplastic ependymoma: a systematic review and a report of metastases to bilateral parotid glands.

Neuro-oncology practice
2020

Myalgia and Hematuria in Association with Clonidine and Arginine Administration for Growth Hormone Stimulation Tests.

Case reports in medicine
2020

cIMPACT-NOW update 7: advancing the molecular classification of ependymal tumors.

Brain pathology (Zurich, Switzerland)
2021

Extensive craniospinal disseminated metastasis after the resection of intradural extramedullary ependymoma in the craniocervical junction: a case report and literature review.

The International journal of neuroscience
2020

Anaplastic ependymoma metastases though a ventriculoperitoneal shunt.

Radiology case reports
2020

Treatment outcome of anaplastic ependymoma under the age of 3 treated by intensity-modulated radiotherapy.

Radiation oncology journal
2020

Cancer treatment in disabled children.

European journal of pediatrics
2020

Contralateral Ventriculostomy for Intraoperative Brain Relaxation in Supratentorial Brain Tumors.

Neurology India
2019

[Turcot syndrome and Gardner's syndrome in a female patient with familial colon adenomatosis. A case report and literature review].

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko
2020

TSC2 alterations in anaplastic ependymoma progression to ependymosarcoma.

Clinical neuropathology
2019

Charcot-Marie-Tooth 1A concurrent with anaplastic ependymoma in a toddler: when an acute event unmasks a chronic condition.

The Turkish journal of pediatrics
2019

World Health Organization Grade III Supratentorial Extraventricular Ependymomas in Adults: Case Series and Review of Treatment Modalities.

Asian journal of neurosurgery
2020

Acute and chronic hemorrhage from radiation-induced cavernous malformation associated with late-delayed radiation necrosis in long surviving glioma patients: A case report.

Oncology letters
2020

Utility of copy number variants in the classification of intracranial ependymoma.

Cancer genetics
2019

Stroke-Like Migraine Attacks after Radiation Therapy Syndrome: Clinical and Imaging Characteristics.

Journal of clinical imaging science
2019

MYCN amplification drives an aggressive form of spinal ependymoma.

Acta neuropathologica
2019

Spinal Cord Ependymomas With MYCN Amplification Show Aggressive Clinical Behavior.

Journal of neuropathology and experimental neurology
2019

Anaplastic Ependymoma and Posterior Fossa Grouping in a Patient With H3K27ME3 Loss of Expression but Chromosomal Imbalance.

Advances in radiation oncology
2019

New therapeutic target for pediatric anaplastic ependymoma control: study of anti-tumor activity by a Kunitz-type molecule, Amblyomin-X.

Scientific reports
2019

A Case of Recurrent Supratentorial Extraventricular Anaplastic Ependymoma in Adult.

Brain tumor research and treatment
2019

Anaplastic ependymoma arising from the lower segment of the uterine corpus: Case report and literature review.

The journal of obstetrics and gynaecology research
2019

Mutation profiling of anaplastic ependymoma grade III by Ion Proton next generation DNA sequencing.

F1000Research
2019

5-ALA fluorescence-guided surgery in pediatric brain tumors-a systematic review.

Acta neurochirurgica
2019

Sudden Unexpected Death in a Child From an Anaplastic Ependymoma.

The American journal of forensic medicine and pathology
2019

Diagnostic errors during intramedullar processes.

Wiadomosci lekarskie (Warsaw, Poland : 1960)
2019

Freiburg Neuropathology Case Conference : Posterior Fossa Mass in an Infant.

Clinical neuroradiology
2018

Unedited microneurosurgery of a pineal region ependymoma.

Surgical neurology international
2019

Telovelar Approach to Pediatric Fourth Ventricle Tumors: Feasibility and Outcome.

Turkish neurosurgery
2019

Individualized treatment for a case of recurrent ovarian ependymoma.

OncoTargets and therapy
2019

Radiosurgery or hypofractionated stereotactic radiotherapy after craniospinal irradiation in children and adults with medulloblastoma and ependymoma.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2018

[Radicalness and complications of repeated surgery for malignant neuroepithelial tumors of the posterior cranial fossa in children].

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko
2019

Microsurgical Resection of Anaplastic Ependymoma of the Cerebellopontine Angle in an Adult: 3-Dimensional Operative Video.

Operative neurosurgery (Hagerstown, Md.)
2018

Myxopapillary ependymoma with anaplastic features: A case report with review of the literature.

Surgical neurology international
2018

Treatment Outcomes in Children and Adolescents with Relapsed or Progressed Solid Tumors: a 20-year, Single-Center Study.

Journal of Korean medical science
2019

L1CAM Immunopositivity in Anaplastic Supratentorial Ependymomas: Correlation With Clinical and Histological Parameters.

International journal of surgical pathology
2018

Pediatric Case of Li-Fraumeni Syndrome Complicated with Supratentorial Anaplastic Ependymoma.

World neurosurgery
2018

[Implantation of VPS in the early postoperative period following removal of posterior cranial fossa tumors in children].

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko
2018

[A Surgical Case of Anaplastic Ependymoma Involving a Bridging Vein that Drained Directly into the Occipital Sinus].

No shinkei geka. Neurological surgery
2018

Preoperative and intraoperative perfusion magnetic resonance imaging in a RELA fusion-positive anaplastic ependymoma: A case report.

Surgical neurology international
2018

Pineal Anaplastic Ependymoma With Multifocal Intradural Extramedullary Metastases on MRI and 18FDG-PET.

Clinical nuclear medicine
2018

DNA methylation-based classification of ependymomas in adulthood: implications for diagnosis and treatment.

Neuro-oncology
2018

Gastroparesis Following Resection of a Fourth-Ventricle Ependymoma in a Child.

World neurosurgery
2018

Primary diffuse large B-cell lymphoma of the choroid plexus: A case report and review of the literature.

Surgical neurology international
2018

Poliovirus Receptor (CD155) Expression in Pediatric Brain Tumors Mediates Oncolysis of Medulloblastoma and Pleomorphic Xanthoastrocytoma.

Journal of neuropathology and experimental neurology
2018

A Missed Differential in an Extra-Axial Lesion with Calvarial Involvement.

Annals of neurosciences
2018

Simultaneous cerebrospinal fluid and hematologic metastases in a high-grade ependymoma.

Surgical neurology international
2018

Supratentorial Pure Cortical Ependymoma: An Unusual Lesion Causing Focal Motor Aware Seizure.

Journal of neurosciences in rural practice
2018

Prognostic Implications of Histological Clear Cells in High-Grade Intracranial Ependymal Tumors: A Retrospective Analysis from a Tertiary Care Hospital in Pakistan.

Asian journal of neurosurgery
2018

Radiation necrosis following proton therapy successfully treated by low-dose bevacizumab in a patient with relapsed anaplastic ependymoma.

Pediatric blood &amp; cancer
2019

Intracranial Neoplasms in the First Year of Life: Results of a Third Cohort of Patients From a Single Institution.

Neurosurgery
2018

Neuroendoscopic Cylinder Surgery and 5-Aminolevulinic Acid Photodynamic Diagnosis of Deep-Seated Intracranial Lesions.

World neurosurgery
2018

Advantages of high b-value diffusion-weighted imaging for preoperative differential diagnosis between embryonal and ependymal tumors at 3 T MRI.

European journal of radiology
2018

Pediatric Isolated Cortical (Ectopic) Anaplastic Ependymoma.

Asian journal of neurosurgery
2018

Adult Supratentorial Extraventricular Anaplastic Ependymoma: Therapeutic Approach and Clinical Review.

Asian journal of neurosurgery
2018

Multimodal treatment including tandem high-dose chemotherapy and autologous stem cell transplantation in children with anaplastic ependymomas.

Pediatric transplantation
2018

Supratentorial Cortical Ependymomas: A Retrospective Series of 13 Cases at a Single Center.

World neurosurgery
2017

Multifocal intradural extramedullary anaplastic ependymoma of the spine.

Journal of spine surgery (Hong Kong)
2018

Surgical Treatment of Spinal Ependymomas: Experience in 49 Patients.

World neurosurgery
2018

Supratentorial extraventricular ependymomas: A retrospective study focused on long-term outcomes and prognostic factors.

Clinical neurology and neurosurgery
2018

EANO guidelines for the diagnosis and treatment of ependymal tumors.

Neuro-oncology
2017

Aggressive Supratentorial Ependymoma, RELA Fusion-Positive with Extracranial Metastasis: A Case Report.

Journal of pathology and translational medicine
2018

RELA fusion-positive anaplastic ependymoma: molecular characterization and advanced MR imaging.

Brain tumor pathology
2018

Ependymomas arising outside of the central nervous system: A case series and literature review.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
2018

Rapid autopsy of a patient with recurrent anaplastic ependymoma.

Palliative &amp; supportive care
2018

Epidemiology, molecular classification and WHO grading of ependymoma.

Journal of neurosurgical sciences
2017

[Radiation Necrosis in the Upper Cervical Spinal Cord in a Patient Treated with Proton Therapy after Radical Resection of the Fourth Ventricle Ependymoma].

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti
2017

Encouraging option of multi-staged gross total resection for a C11orf-RelA fusion-positive supratentorial anaplastic ependymoma.

Brain tumor pathology
2017

Clinical Features of a Family with Multiple Endocrine Neoplasia Type 2A Caused by the D631Y RET Mutation.

Thyroid : official journal of the American Thyroid Association
2018

Surgery for spinal intramedullary tumors: technique, outcome and factors affecting resectability.

Neurosurgical review
2017

Systemic metastases from central nervous system ependymoma: case report and review of the literature.

The neuroradiology journal
2017

Spinal cord anaplastic ependymoma induced by radiation treatment of breast cancer.

Journal of neurosurgical sciences
2017

Anaplastic Ependymoma With Ganglionic Differentiation: Report of a Rare Case and Implications in Diagnosis.

International journal of surgical pathology
2017

Pediatric Basal Ganglia Region Tumors: Clinical and Radiologic Features Correlated with Histopathologic Findings.

World neurosurgery
2017

Hormonal based treatment of ovarian anaplastic ependymoma with anastrozole.

Gynecologic oncology reports
2017

Multiple intradural-extramedullary spinal ependymomas including tumors with different histological features.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
2017

Lipomatous/Extensively Vacuolated Ependymoma with Signet-Ring Cell-Like Appearance: Analysis of a Case with Extensive Literature Review.

Case reports in pathology
2017

"Drop" Metastases from an Operated Case of Intracranial Anaplastic Ependymoma Identified on Fluoro-2-deoxyglucose Positron Emission Tomography/Computed Tomography.

Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India
2016

Extra-axial giant falcine ependymoma with ultra-rapid growth in child: Uncommon entity with literature review.

Journal of pediatric neurosciences
2017

Feline glioma: a retrospective study and review of the literature.

Journal of feline medicine and surgery
2016

Update on malignancies in children with juvenile idiopathic arthritis in the German BIKER Registry.

Clinical and experimental rheumatology
2016

Angiocentric glioma transformed into anaplastic ependymoma: Review of the evidence for malignant potential.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
2016

Magnetic resonance imaging findings of extraventricular anaplastic ependymoma: A report of 11 cases.

Oncology letters
2016

Novel fusion genes and chimeric transcripts in ependymal tumors.

Genes, chromosomes &amp; cancer
2016

Altered MicroRNA Expression Is Associated with Tumor Grade, Molecular Background and Outcome in Childhood Infratentorial Ependymoma.

PloS one
2016

Brain Tumor in an In Vitro Fertilization-Facilitated Pregnancy: Fourth Ventricle Anaplastic Ependymoma in the Second Trimester.

Journal of neurological surgery reports
2017

Supratentorial extraventricular WHO grade III (anaplastic) ependymoma 17 years after total removal of WHO grade II ependymoma of the fourth ventricle.

British journal of neurosurgery
2016

Pure extra-axial supratentorial anaplastic ependymoma with no cortical attachment: A rare case.

Neurology India
2016

Primary Intracranial Extra-Axial Anaplastic Ependymomas.

World neurosurgery
2016

Radiation-induced anaplastic ependymoma mimicking a skull base meningioma: A case report.

Experimental and therapeutic medicine
2016

Re-irradiation of recurrent anaplastic ependymoma using radiosurgery or fractionated stereotactic radiotherapy.

Japanese journal of radiology
2016

Autonomic dysfunction elicited by a medulla oblongata injury after fourth ventricle tumor surgery in a pediatric patient.

Autonomic neuroscience : basic &amp; clinical
2015

Anaplastic extramedullary cervical ependymoma with leptomeningeal metastasis.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
2015

An extraneural primary anaplastic ependymoma at the subcutaneous inguinal region: Report of a rare case.

Indian journal of pathology &amp; microbiology
2016

Anaplastic Ependymoma in a Child With Sickle Cell Anemia: A Case Report Highlighting Treatment Challenges for Young Children With Central Nervous System Tumors and Underlying Vasculopathy.

Pediatric blood &amp; cancer
2016

Multiomics approach showing genome-wide copy number alterations and differential gene expression in different types of North-Indian pediatric brain tumors.

Gene
2015

A rare case of malignant pediatric ectomesenchymoma arising from the cerebrum.

International journal of clinical and experimental pathology
2016

Temozolomide Treatment for Pediatric Refractory Anaplastic Ependymoma with Low MGMT Protein Expression.

Pediatric blood &amp; cancer
2015

Role of Evaluating MGMT Status and 1p36 Deletion in Radiosurgery-Induced Anaplastic Ependymoma That Rapidly and Completely Resolved by Temozolomide Alone: Case Report and Review of the Literature.

Journal of neurological surgery reports
2015

Malignant Transformation of Grade II Ependymoma in a 2-Year-Old Child: Case Report.

Journal of neurological surgery reports
2015

Qualitative analysis of spinal intramedullary lesions using PET/CT.

Journal of neurosurgery. Spine
2015

An 11 Year Old Child with a Right Parieto-Occipital Lesion. Anaplastic Ependymoma (WHO Grade III) with Granular Cell Features.

Brain pathology (Zurich, Switzerland)
2015

Predictors of survival in patients with spinal ependymoma.

Neurological research
2015

Paediatric intracranial anaplastic ependymoma: the role of multiple surgical resections for disease relapse in maintaining quality of life and prolonged survival.

Pediatric neurosurgery
2015

An open-label, two-stage, phase II study of bevacizumab and lapatinib in children with recurrent or refractory ependymoma: a collaborative ependymoma research network study (CERN).

Journal of neuro-oncology
2015

Anaplastic ependymoma of spinal cord presented with low back pain.

The spine journal : official journal of the North American Spine Society
2015

Infratentorial ependymomas--a study of the centre in Katowice.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2015

An integrative analysis of treatment, outcomes and prognostic factors for primary spinal anaplastic ependymomas.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
2015

Neoadjuvant chemotherapy for brain tumors in infants and young children.

Journal of neurosurgery. Pediatrics
2016

Evaluating the apparent diffusion coefficient in MRI studies as a means of determining paediatric brain tumour stages.

Neurologia (Barcelona, Spain)

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Thoracic tanycytic ependymoma with anaplastic progression after subtotal resection and repeated radiotherapy: A 17-year follow-up case report.
    Surgical neurology international· 2026· PMID 41660332mais citado
  2. Nivolumab-Associated Autoimmune Encephalopathy in a Child With Multiply Relapsed Anaplastic Ependymoma.
    Pediatric blood &amp; cancer· 2026· PMID 41846303mais citado
  3. Recurrent pediatric posterior fossa anaplastic ependymoma managed with multiple resections: illustrative case.
    Journal of neurosurgery. Case lessons· 2026· PMID 41569674mais citado
  4. Clinical Features and Prognostic Indicators for Brainstem Ependymomas : A Population-Based Retrospective Surveillance, Epidemiology, and End Results Database Analysis.
    Journal of Korean Neurosurgical Society· 2026· PMID 41461149mais citado
  5. Characteristics and therapeutic profile of the patients with upper cervical spinal cord ependymoma from the medulla oblongata to C4: A cohort of 108 cases.
    Clinical neurology and neurosurgery· 2025· PMID 39889612mais citado
  6. Extraspinal sacrococcygeal anaplastic ependymoma: A case report.
    Int J Surg Case Rep· 2025· PMID 41541159recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:251646(Orphanet)
  2. MONDO:0016700(MONDO)
  3. GARD:10634(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Q19000645(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Ependimoma anaplásico
Compêndio · Raras BR

Ependimoma anaplásico

ORPHA:251646 · MONDO:0016700
Prevalência
<1 / 1 000 000
Herança
Not applicable
CID-10
C71.9 · Neoplasia maligna do encéfalo, não especificado
CID-11
Ensaios
5 ativos
Início
Adolescent, Adult, Childhood
Prevalência
0.04 (United States)
MedGen
UMLS
C0280788
Repurposing
1 candidato
carmustineDNA alkylating agent|DNA inhibitor
EuropePMC
Wikidata
Papers 10a
DiscussaoAtiva

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