Introdução
O que você precisa saber de cara
Acromegalia é um distúrbio que resulta no crescimento excessivo de certas partes do corpo humano. É causada pelo excesso de hormônio do crescimento (GH) após o fechamento das placas de crescimento. O sintoma inicial é tipicamente o aumento das mãos e dos pés. Pode também haver um aumento da testa, mandíbula e nariz. Outros sintomas podem incluir dor nas articulações, espessamento da pele, aprofundamento da voz, dores de cabeça e problemas de visão. As complicações da doença podem incluir diabetes tipo 2, apneia do sono e pressão alta.
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Entender a doença
Do básico ao detalhe, leia no seu ritmo
Preparando trilha educativa...
Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 27 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 60 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Genética e causas
O que está alterado no DNA e como passa nas famílias
Nenhum gene associado encontrado
Os dados genéticos desta condição ainda estão sendo catalogados.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Adenoma hipofisário funcional misto
Selecione um estado ou use sua localização para ver resultados.
Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Pesquisa e ensaios clínicos
Nenhum ensaio clínico registrado para esta condição.
Publicações mais relevantes
Clinical and radiological features of Rathke's cleft cysts with inflammatory change: Multivariable analysis of 262 surgically treated cases.
To characterize clinical and MRI features of Rathke's cleft cysts (RCCs) with inflammatory change and assess their associations with endocrine and surgical outcomes. We retrospectively reviewed 262 surgically treated RCCs at a single institution (1998-2023). All patients underwent preoperative MRI and endocrine testing. Postoperative pathology classified cases as with inflammatory change (Group A, n = 56) or without (Group B, n = 206). Group comparisons used standard statistics; key MRI signs were circumferential rim enhancement and mixed T2 signal. Compared with Group B, Group A had more impaired pituitary axes (mean 3.9 vs. 1.1; p < 0.001) and higher rates of diabetes insipidus (33.9 % vs. 1.5 %; p < 0.0001) and visual field defects (62.5 % vs. 31.6 %; p < 0.0001). Circumferential rim enhancement (71.4 % vs. 6.3 %; p < 0.0001) and mixed T2 signal (66.1 % vs. 6.8 %; p < 0.0001) were strongly associated with inflammatory change. Postoperative endocrine recovery was less frequent in Group A (21.7 % vs. 64.6 %; p < 0.0001), and reoperation for recurrence was more common (14.3 % vs. 2.4 %; p = 0.001). Two illustrative cases demonstrated concordance between inflammation severity, MRI features, and outcomes. RCCs with inflammatory change are associated with severe preoperative pituitary dysfunction, poorer endocrine recovery, and higher recurrence. Simple MRI signs-especially circumferential rim enhancement and mixed T2 signal-may help identify inflammatory cases preoperatively and support consideration of earlier surgical intervention to preserve pituitary function.
Redefining Pituitary Neuroendocrine Tumors in MEN1: Prevalence, Clinical Behavior, and Implications for Long-Term Surveillance.
Pituitary neuroendocrine tumors (PitNETs) are a core manifestation of multiple endocrine neoplasia type 1 (MEN1), yet their true prevalence, biological behavior, and optimal management remain debated. Earlier reports suggested increased aggressiveness compared with sporadic PitNETs, while more recent surveillance-based studies indicate a predominantly indolent phenotype. We conducted a retrospective single-center study including all patients with clinical, familial, or genetic MEN1 referred to the Endocrinology Unit of the University of Naples "Federico II", ENETS Center of Excellence, between January 2004 and June 2025. Demographic, clinical, radiological, hormonal, and therapeutic data were systematically collected. PitNETs were classified by size and hormonal activity. Among 103 MEN1 patients (61 women), 50 (48.5%) were diagnosed with PitNETs at a mean age of 35.1 years. Microadenomas predominated (60%), and tumors were equally distributed between functioning and non-functioning lesions. Prolactin-secreting PitNETs were the most common functioning subtype (42%), followed by rare GH-, ACTH-, or mixed-secreting PitNETs. Dopamine agonists, mainly cabergoline, were prescribed in 38% of cases, while neurosurgical intervention was required in 14%, exclusively for macroadenomas. During follow-up, recurrence occurred in 8% of patients. No significant sex-related differences were observed in prevalence, tumor size, functional status, treatment approach, or outcomes. In our MEN1 cohort, PitNETs were frequent but largely indolent, with a predominance of microadenomas and limited need for surgery. Our findings support individualized, subtype-driven surveillance strategies, with conservative management for clinically non-functioning microadenomas and closer monitoring of prolactin-secreting PitNETs due to variable medical responsiveness.
Proton versus photon radiotherapy in adults with primary brain tumors evaluating functional survival: a phase 3 randomized controlled trial study protocol (PRIDE).
Radiation therapy (RT) plays a significant role in the multimodal management of primary brain tumors, improving oncological outcomes. However, despite advances such as Intensity-Modulated Radiation Therapy (IMRT), photon-based RT inevitably exposes normal organs to low-dose radiation, leading to long-term functional morbidities like cognitive decline, endocrine dysfunction, auditory toxicity. These late effects are particularly concerning in patients with favorable prognoses and protracted survival. Proton beam therapy (PBT), owing to its unique physical properties, holds promise for better functional preservation, but robust clinical data in adults are lacking. The PRIDE study is a prospective, open-label, phase 3 randomized controlled trial enrolling adults aged 18-70 years undergoing focal cranial RT with conventional fractionation for primary brain tumors with expected survival > 5 years at Tata Memorial Centre, Mumbai. Participants will be randomized 1:1 to receive either photon-IMRT (standard arm) or PBT (experimental arm), stratified by age, tumor type, proximity to the hypothalamic-pituitary axis, and radiation dose. The primary endpoint is 5-year functional survival, defined as survival without functional deterioration (neurocognitive decline, significant ototoxicity, new or worsening endocrine dysfunction, neurological impairment, severe radio-necrosis, disease progression, or death). Secondary endpoints include patient-reported quality of life and health economic analysis. Survival outcomes will be analyzed using Kaplan-Meier methods with log-rank test. Neurocognitive and quality-of-life data will be evaluated using linear mixed-effects and non-parametric tests. A total of 156 patients will be enrolled, accounting for 20% attrition, to detect a 25% absolute improvement in 5-year functional survival favoring PBT (65% vs 40%, HR 0.47, α=0.05, power=80%). An interim analysis has been planned using the O'Brien-Fleming rule after 50% of the events (n=28). This trial will provide level 1 evidence investigating the role of PBT in functional outcomes among adults with primary brain tumors. If study endpoint is achieved, PBT will be considered as standard of care guiding contemporary neuro-oncology practice. The trial has been approved by the Institutional Ethics Committee of Tata Memorial Centre, Mumbai. The trial has been registered with the Clinical Trial Registry of India (CTRI/2025/03/082568) and Clinicaltrials.gov (study identifier NCT06831461).
Mixed gangliocytoma-pituitary neuroendocrine tumour: clinical, immunohistochemical, and molecular genetic profiles in a series of four patients.
The vast majority of tumours in the sellar region are pituitary neuroendocrine tumours, also called pituitary adenomas. Sellar gangliocytomas (GCs), benign tumours that originate from neuronal ganglionic cells, account for less than 1% of sellar tumours. Even rarer are mixed gangliocytoma-pituitary neuroendocrine tumours (GC-PitNET). These tumours are often associated with hormone hypersecretion, most commonly resulting in acromegaly. The histogenesis of mixed GC-PitNET is currently unclear. In this paper, we present comprehensive clinical, immunohistochemical, targeting enrichment next generation DNA sequencing, and genome-wide methylation data from four patients with mixed GC-PitNETs, three with acromegaly and one with Cushing's disease. Transcriptomic data are also included for two of the patients. Our findings indicate that mixed GC-PitNETs have different clinical course, with the acromegaly patients showing greater resistance to pharmacological therapy, as well as different protein expression and molecular features compared to respective pure PitNETs. The transcriptomic data on two patients with somatotroph GC-PitNET show involvement of mitochondrial and ribosomal genes, suggesting a distinct gene expression pattern, in comparison with pure somatotroph tumours. Furthermore, the expression pattern of selected stem cell markers, mainly SOX9, supports a common origin of the neuroendocrine and ganglionic tumour components, suggesting the involvement of stem cells in tumorigenesis.
Cabergoline monotherapy in GH- and PRL-cosecreting pituitary adenomas.
Functional pituitary tumours, also called pituitary neuroendocrine tumours (PitNETs), typically produce a single hormone, based on the cell lineage from which they arise in the anterior pituitary. Pituitary adenoma dual hypersecretion is less common and may present management dilemmas. Prolactin (PRL) and growth hormone (GH) co-secreting pituitary adenomas (GH and PRL-PA) are the most common form of pituitary adenoma dual hypersecretion, arising from PIT1-lineage PitNETs, most commonly mammosomatotroph and mixed somatotroph-lactotroph adenomas. Pharmacotherapies employed in prolactinoma (i.e. dopamine agonists) and acromegaly (e.g. somatostatin analogues) may be used in GH and PRL-PA, in addition to transsphenoidal surgery. However, the ideal treatment of this rare PA subtype is unknown, reflected by a lack of specific treatment recommendations in both acromegaly and prolactinoma guidelines. Herein, we present an individual with a giant GH and PRL-PA with complete biochemical (GH and PRL), and partial structural, ophthalmological and clinical, responses to upfront cabergoline monotherapy. This case, along with previous data showing GH and structural responses to cabergoline in individuals with acromegaly and hyperprolactinaemia, argue for a role for cabergoline monotherapy in the treatment armamentarium of GH and PRL-PAs, noting that some tumours may exhibit a significant treatment response as observed here. GH and PRL-PA is a typically aggressive form of pituitary adenoma.Cabergoline monotherapy can be an effective treatment option for select case of GH and PRL-PA, resulting in both biochemical and structural responses.Some GH and PRL-PAs may exhibit a 'hyper-response' to cabergoline with rapid, profound hormone reduction and/or tumour shrinkage.
Publicações recentes
Mixed gangliocytoma-pituitary neuroendocrine tumour: clinical, immunohistochemical, and molecular genetic profiles in a series of four patients.
Clinical and radiological features of Rathke's cleft cysts with inflammatory change: Multivariable analysis of 262 surgically treated cases.
Brain injury biomarkers and intraoperative hypotension: associations with pituitary hormone deficiency following transsphenoidal endoscopic surgery for non-functioning pituitary adenomas.
Transcriptomic classification of prolactinomas and somatotropinomas identifies subtypes with variable resistance to treatment.
Comprehensive Comparison of Visual Outcomes in Macro and Giant Prolactinoma Cohorts Managed With Medical Versus Surgical Treatment.
📚 EuropePMCmostrando 119
Redefining Pituitary Neuroendocrine Tumors in MEN1: Prevalence, Clinical Behavior, and Implications for Long-Term Surveillance.
Current oncology (Toronto, Ont.)Proton versus photon radiotherapy in adults with primary brain tumors evaluating functional survival: a phase 3 randomized controlled trial study protocol (PRIDE).
Radiation oncology (London, England)Mixed gangliocytoma-pituitary neuroendocrine tumour: clinical, immunohistochemical, and molecular genetic profiles in a series of four patients.
Acta neuropathologica communicationsCabergoline monotherapy in GH- and PRL-cosecreting pituitary adenomas.
Endocrine oncology (Bristol, England)Clinical and radiological features of Rathke's cleft cysts with inflammatory change: Multivariable analysis of 262 surgically treated cases.
Clinical neurology and neurosurgeryBrain injury biomarkers and intraoperative hypotension: associations with pituitary hormone deficiency following transsphenoidal endoscopic surgery for non-functioning pituitary adenomas.
PituitaryAcromegaly and breast cancer risk: evidence from a systematic review and meta-analysis.
Frontiers in endocrinologyTranscriptomic classification of prolactinomas and somatotropinomas identifies subtypes with variable resistance to treatment.
European journal of endocrinologyProspectively assessed hypothalamic-pituitary dysfunction after proton therapy in adults with head and neck, skull base and brain tumors.
Scientific reportsComprehensive Comparison of Visual Outcomes in Macro and Giant Prolactinoma Cohorts Managed With Medical Versus Surgical Treatment.
NeurosurgeryEpidemiologic Profile and Clinical Outcomes of Adult Patients with Prolactinoma at the Philippine General Hospital.
Acta medica PhilippinaMinimally Invasive Cyst Drainage for Cystic Craniopharyngioma: Neuroendoscopic Fenestration or Stereotactic Cyst Drainage?
World neurosurgeryEndoscopic endonasal surgery using indocyanine green fluorescence endoscope for Cushing's disease caused by mixed intrasellar gangliocytoma and adrenocorticotropin adenoma: illustrative case.
Journal of neurosurgery. Case lessonsIntegrative Machine Learning Approach for Predicting Resistance to First-generation Receptor Ligands in Acromegaly.
The Journal of clinical endocrinology and metabolismPrevalence, risk factors, and impacts of sleep disturbances in patients with primary brain tumors: a systematic review.
Neurosurgical reviewExpanding the phenotype of multiple endocrine neoplasia type 5 (MEN5): Pituitary gigantism, myelolipoma and familial pheochromocytoma due to a germline pathogenic MAX variant.
EndocrineThe oxytocin system in patients with craniopharyngioma: A systematic review.
Frontiers in neuroendocrinologyFugitive Acromegaly: A Historical, Clinical, and Translational Perspective.
Frontiers of hormone researchGH-Secreting Adenoma or Tumor? Issues in Pituitary Neoplasms Nomenclature, Classification, and Characterization.
Frontiers of hormone researchMixed Gangliocytoma-Pituitary Adenoma: A Systematic Review of Diagnostic Features, Clinical Management, and Surgical Outcomes.
World neurosurgeryB2R-D2R Interaction in Prolactinomas and Nonfunctional Adenomas: Impact on Dopamine Resistance.
EndocrinologyDeleterious effects of social isolation on neuroendocrine-immune status, and cancer progression in rats.
Brain, behavior, and immunityA multicenter study of clinical outcomes and volumetric trends in suspected microprolactinomas.
Neurosurgical review[Clinical case of plurihormonal pituitary adenoma (STH/ACTH/TSH/FSH/LH-secreting), diagnostic pitfalls].
Problemy endokrinologiiGenome-Wide DNA Methylation Profiling as a Prognostic Marker in Pituitary Adenomas-A Pilot Study.
CancersMixed pituitary adenoma/pituitary neuroendocrine tumor-gangliocytoma: Immunohistochemical insights.
Journal of neuropathology and experimental neurologyShaping the curve from the microscopic transsphenoidal to the endoscopic endonasal approach for the sellar region.
Cirugia y cirujanosEndoscopic endonasal transsphenoidal approach improves endocrine function and surgical outcome in primary craniopharyngioma resection: a systematic review and meta-analysis.
World journal of surgical oncologyComplete Shrinking of Mixed Growth Hormone and Prolactin-Secreting Pituitary Adenoma With Bromocriptine Therapy Alone.
The Journal of craniofacial surgeryPatient reported outcomes and patient experiences of immune checkpoint modulators for advanced or recurrent melanoma: a mixed methods study.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in CancerThe Genetic Pathophysiology and Clinical Management of the TADopathy, X-Linked Acrogigantism.
Endocrine reviewsHistopathology of growth hormone-secreting pituitary tumors: State of the art and new perspectives.
Best practice & research. Clinical endocrinology & metabolismEnhanced outcomes in residual or recurrent craniopharyngioma: evaluating combined gamma knife and phosphorus-32 brachytherapy.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of MexicoDifferences Between GH- and PRL-Cosecreting and GH-Secreting Pituitary Adenomas: a Series of 604 Cases.
The Journal of clinical endocrinology and metabolismClinical Characteristics of Childhood-Onset Craniopharyngioma.
Alternative therapies in health and medicineClinical Characteristics, Diagnosis, and Treatment of Thyroid Stimulating Hormone-Secreting Pituitary Neuroendocrine Tumor (TSH PitNET): A Single-Center Experience.
Endocrinology and metabolism (Seoul, Korea)PAM variants in patients with thyrotrophinomas, cyclical Cushing's disease and prolactinomas.
Frontiers in endocrinologyThe Value of ER∝ in the Prognosis of GH- and PRL-Secreting PitNETs: Clinicopathological Correlations.
International journal of molecular sciencesProlactin and Growth Hormone Signaling and Interlink Focused on the Mammosomatotroph Paradigm: A Comprehensive Review of the Literature.
International journal of molecular sciencesDetermination of PDK1, SLC2A1, EGFR, PTEN, CD276 Gene Expression Levels and IDH1 Gene R132H Polymorphism in Brain Tumor Tissues.
Turkish neurosurgeryGermline loss-of-function PAM variants are enriched in subjects with pituitary hypersecretion.
Frontiers in endocrinologyAltered hemispheric asymmetry of attentional networks in patients with pituitary adenoma: an event-related potential study.
Frontiers in neuroscienceRefractory Pit1 plurihormonal tumours and thyrotroph adenomas.
PituitarySocial determinants of cognitive outcomes in survivors of pediatric brain tumors treated with conformal radiation therapy.
Neuro-oncologyComparison of neurocognitive and quality-of-life outcomes in pediatric craniopharyngioma patients treated with partial resection and radiotherapy versus gross-total resection only.
Journal of neurosurgery. PediatricsA rare pituitary tumor associated with hyperthyroidism and acromegaly.
Frontiers in endocrinology[New pathological classification and clinical implications of pituitary neuroendocrine tumors of the 2022 WHO version].
Zhonghua yi xue za zhiTranscriptomic Classification of Pituitary Neuroendocrine Tumors Causing Acromegaly.
CellsPituitary-testis axis dysfunction following adjuvant androgen deprivation therapy.
Endocrine-related cancerAspirin Mediates Its Antitumoral Effect Through Inhibiting PTTG1 in Pituitary Adenoma.
The Journal of clinical endocrinology and metabolismPathological and Prognostic Characterization of Craniopharyngioma Based on the Expression of TrkA, β-Catenin, Cell Cycle Markers, and BRAF V600E Mutation.
Frontiers in endocrinologyObservation of Clinicopathologic Features of Pituitary Adenoma With Neuronal Differentiation.
Frontiers in endocrinologyOverview of the 2022 WHO Classification of Neuroendocrine Neoplasms.
Endocrine pathologyOsilodrostat oral tablets for adults with Cushing's disease.
Expert review of endocrinology & metabolismMixed gangliocytoma-pituitary adenoma in MEN1 syndrome: A case report and literature review.
Neuropathology : official journal of the Japanese Society of NeuropathologyEquivalent outcomes in nasal symptoms following microscopic or endoscopic transsphenoidal surgery: results from multi-centre, prospective study.
Acta neurochirurgicaGamma knife radiosurgery in pituitary adenomas. A single-center experience.
MedicinaNovel Classification of Acromegaly in Accordance with Immunohistochemical Subtypes: Is There Really a Clinical Relevance?
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolismeEndocrine Disrupting Chemicals and Reproductive Health in Boys and Men.
Frontiers in endocrinologySleep disturbances in craniopharyngioma: a challenging diagnosis.
Journal of neurologyMultiple roles for peptidylglycine α-amidating monooxygenase in the response to hypoxia.
Journal of cellular physiologyAltered endocannabinoid-dynamics in craniopharyngioma patients and their association with HPA-axis disturbances.
European journal of endocrinologyA Potential Concomitant Sellar Embryonic Remnant-Associated Collision Tumor: Systematic Review.
Frontiers in oncologyPD-L1 Is Preferentially Expressed in PIT-1 Positive Pituitary Neuroendocrine Tumours.
Endocrine pathologyThe impact of socioeconomic status (SES) on cognitive outcomes following radiotherapy for pediatric brain tumors: a prospective, longitudinal trial.
Neuro-oncologyPrimary intrasellar schwannoma with intratumoral hemorrhage mimicking pituitary apoplexy: A case report.
Neuro-ChirurgieCraniopharyngioma in the Elderly: A Multicenter and Nationwide Study in Spain.
NeuroendocrinologyCystic appearance on magnetic resonance imaging in bihormonal growth hormone and prolactin tumors in acromegaly.
PituitaryPediatric pituitary adenoma with mixed FSH and TSH immunostaining and FSH hypersecretion in a 6 year-old girl with precocious puberty: case report and multidisciplinary management.
The International journal of neurosciencePituitary Gangliocytoma Producing TSH and TRH: A Review of "Gangliocytomas of the Sellar Region".
The Journal of clinical endocrinology and metabolismMixed Sparsely Granulated Lactotroph and Densely Granulated Somatotroph Pituitary Neuroendocrine Tumor Expands the Spectrum of Neuroendocrine Neoplasms in Ovarian Teratomas: the Role of Pituitary Neuroendocrine Cell Lineage Biomarkers.
Endocrine pathologyPrior smoking and nasoseptal flap usage adversely impact quality of life and healing after endoscopic pituitary surgery.
Neurosurgical focusPrimary papillary epithelial tumour of the sella: expanding the spectrum of TTF-1-positive sellar lesions.
Neuropathology and applied neurobiologyDiagnosing Thyrotropin-Secreting Pituitary Adenomas by Short-Term Somatostatin Analogue Test.
Thyroid : official journal of the American Thyroid AssociationAdult craniopharyngioma: The role of extent of resection in tumor recurrence and long-term functional outcome.
Clinical neurology and neurosurgeryPatients with true mixed growth hormone and prolactin-secreting pituitary adenoma: a case series of 12 patients.
British journal of neurosurgery10 Years' Experience of Using Low-Field Intraoperative MRI in Transsphenoidal Surgery for Pituitary Adenoma: Results of the Swiss Pituitary Registry (SwissPit).
World neurosurgeryA Novel, Hybrid, Stereotactic Approach (Radiosurgery and Dual Ommaya Reservoirs) for the Treatment of Mixed (Polycystic and Solid) Craniopharyngioma.
Stereotactic and functional neurosurgeryFunctioning Pituitary Adenoma with Xanthogranulomatous Features: Review of Literature and Case Report.
Journal of neurological surgery. Part B, Skull baseSellar/Suprasellar Ganglioglioma: Clinical Image.
World neurosurgeryComprehensive Evaluation of Rare Pituitary Lesions: A Single Tertiary Care Pituitary Center Experience and Review of the Literature.
Endocrine pathologyPrediction of calcification tendency in pediatric cystic adamantinomatous craniopharyngioma by using inflammatory markers, hormone markers, and radiological appearances.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryPrimary tumors of the posterior pituitary: A systematic review.
Reviews in endocrine & metabolic disordersEx Vivo 1H NMR study of pituitary adenomas to differentiate various immunohistochemical subtypes.
Scientific reportsPGAM5-CypD pathway is involved in bromocriptine-induced RIP3/MLKL-dependent necroptosis of prolactinoma cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapiePediatric pituitary adenomas in Northeast Mexico. A follow-up study.
EndocrinePredicting parental distress among children newly diagnosed with craniopharyngioma.
Pediatric blood & cancerPituitary adenomas in children and young adults.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryEpidemiology and biomarker profile of pituitary adenohypophysial tumors.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, IncA prospective longitudinal study of Pasireotide in Nelson's syndrome.
PituitarySilent somatotroph pituitary adenomas: an update.
PituitaryHMGA2 cooperates with either p27kip1 deficiency or Cdk4R24C mutation in pituitary tumorigenesis.
Cell cycle (Georgetown, Tex.)Editor's Highlight: Structure-Based Investigation on the Binding and Activation of Typical Pesticides With Thyroid Receptor.
Toxicological sciences : an official journal of the Society of ToxicologyUnusual presentations of Carney Complex in patient with a novel PRKAR1A mutation.
Neuro endocrinology lettersAdrenal Cushing's syndrome during pregnancy.
European journal of endocrinologyAn FSH and TSH pituitary adenoma, presenting with precocious puberty and central hyperthyroidism.
Endocrinology, diabetes & metabolism case reportsX-LAG: How did they grow so tall?
Annales d'endocrinologieEpigenetic Pathways in Human Disease: The Impact of DNA Methylation on Stress-Related Pathogenesis and Current Challenges in Biomarker Development.
EBioMedicineHigh Ki-67 expression is associated with prolactin secreting pituitary adenomas.
Bosnian journal of basic medical sciencesScreening for genetic causes of growth hormone hypersecretion.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research SocietyA Case of Mixed Germ Cell Tumor in the Intramedullary Spinal-cord.
The Tokai journal of experimental and clinical medicineSelection and validation of reliable reference genes for RT-qPCR analysis in a large cohort of pituitary adenomas.
Molecular and cellular endocrinologyTREM-1 expression in craniopharyngioma and Rathke's cleft cyst: its possible implication for controversial pathology.
OncotargetIn vitro impact of pegvisomant on growth hormone-secreting pituitary adenoma cells.
Endocrine-related cancerNogo-A inhibits the migration and invasion of human malignant glioma U87MG cells.
Oncology reportsThree-dimensional Alginate-bead Culture of Human Pituitary Adenoma Cells.
Journal of visualized experiments : JoVE[Misleading diagnosis of hyperprolactinemia in women].
Gynecologie, obstetrique & fertiliteUnicystic Ameloblastomatoid Cystic Craniopharyngioma: Pathological Discussion and Clinical Significance of Cyst Formation in Adamantinomatous Craniopharyngioma.
Pediatric neurosurgeryGHRH excess and blockade in X-LAG syndrome.
Endocrine-related cancerLocally produced estrogen through aromatization might enhance tissue expression of pituitary tumor transforming gene and fibroblast growth factor 2 in growth hormone-secreting adenomas.
EndocrineStereotactic intracavitary brachytherapy with P-32 for cystic craniopharyngiomas in children.
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]GHRH Receptor Expression in Malignant Mixed Müllerian Tumors: A Potentially Targetable Biopredictor.
International journal of gynecological pathology : official journal of the International Society of Gynecological PathologistsGanglion cell tumours in the sella turcica in close morphological connection with pituitary adenomas.
Folia neuropathologicaMonomorphous Plurihormonal Pituitary Adenoma of Pit-1 Lineage in a Giant Adolescent with Central Hyperthyroidism.
Endocrine pathologySellar gangliocytoma with adrenocorticotropic and prolactin adenoma.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of AustralasiaPrimary Medical Treatment of Thyrotropin-Secreting Pituitary Adenomas by First-Generation Somatostatin Analogs: A Case Study of Seven Patients.
Thyroid : official journal of the American Thyroid AssociationNeuropsychiatric and cardiometabolic comorbidities in patients with previously diagnosed Cushing's disease: a longitudinal observational study.
BMJ openReduced sleep quality and depression associate with decreased quality of life in patients with pituitary adenomas.
European journal of endocrinologyA semi-mechanistic integrated pharmacokinetic/pharmacodynamic model of the testosterone effects of the gonadotropin-releasing hormone agonist leuprolide in prostate cancer patients.
Clinical pharmacokineticsAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
Ainda não temos associações cadastradas para Adenoma hipofisário funcional misto.
É de uma associação que acompanha esta doença? Fale com a gente →
Comunidades
Grupos ativos de quem convive com esta doença aqui no Raras
Ainda não existe comunidade no Raras para Adenoma hipofisário funcional misto
Pacientes, familiares e cuidadores se organizam em comunidades pra compartilhar experiências, fazer perguntas e se apoiar. Você pode ser o primeiro.
Tire suas dúvidas
Perguntas, dicas e experiências compartilhadas aqui na página
Participe da discussão
Faça login para postar dúvidas, compartilhar experiências e interagir com especialistas.
Fazer loginDoenças relacionadas
Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico
Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Clinical and radiological features of Rathke's cleft cysts with inflammatory change: Multivariable analysis of 262 surgically treated cases.
- Redefining Pituitary Neuroendocrine Tumors in MEN1: Prevalence, Clinical Behavior, and Implications for Long-Term Surveillance.
- Proton versus photon radiotherapy in adults with primary brain tumors evaluating functional survival: a phase 3 randomized controlled trial study protocol (PRIDE).
- Mixed gangliocytoma-pituitary neuroendocrine tumour: clinical, immunohistochemical, and molecular genetic profiles in a series of four patients.
- Cabergoline monotherapy in GH- and PRL-cosecreting pituitary adenomas.
- Brain injury biomarkers and intraoperative hypotension: associations with pituitary hormone deficiency following transsphenoidal endoscopic surgery for non-functioning pituitary adenomas.
- Transcriptomic classification of prolactinomas and somatotropinomas identifies subtypes with variable resistance to treatment.
- Comprehensive Comparison of Visual Outcomes in Macro and Giant Prolactinoma Cohorts Managed With Medical Versus Surgical Treatment.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:314759(Orphanet)
- MONDO:0017822(MONDO)
- GARD:21390(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Q55787418(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
