É uma doença rara que afeta o cérebro, caracterizada por muita sonolência, músculos muito moles, dificuldade para mamar, postura com o corpo arqueado para trás e um choro agudo e diferente. Isso acontece porque uma substância, a bilirrubina, se acumula em algumas regiões do cérebro. A causa é uma icterícia (o "amarelão") grave em recém-nascidos, com níveis muito altos de bilirrubina no sangue. Os primeiros sintomas geralmente aparecem entre o terceiro e o quinto dia de vida. Outros sinais que podem surgir são febre, paradas na respiração, convulsões e coma. Principalmente a dificuldade grave para respirar ou convulsões que não melhoram com o tratamento podem ser fatais.
Introdução
O que você precisa saber de cara
É uma doença rara que afeta o cérebro, caracterizada por muita sonolência, músculos muito moles, dificuldade para mamar, postura com o corpo arqueado para trás e um choro agudo e diferente. Isso acontece porque uma substância, a bilirrubina, se acumula em algumas regiões do cérebro. A causa é uma icterícia (o "amarelão") grave em recém-nascidos, com níveis muito altos de bilirrubina no sangue. Os primeiros sintomas geralmente aparecem entre o terceiro e o quinto dia de vida. Outros sinais que podem surgir são febre, paradas na respiração, convulsões e coma. Principalmente a dificuldade grave para respirar ou convulsões que não melhoram com o tratamento podem ser fatais.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Entender a doença
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 9 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 20 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Nenhum gene associado encontrado
Os dados genéticos desta condição ainda estão sendo catalogados.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Encefalopatia devido a hiperbilirrubinemia aguda
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1 ensaios clínicos encontrados.
Publicações mais relevantes
Predominance of Rh-mediated haemolytic disease driving exchange transfusions in rural north India: A five-year retrospective analysis revealing critical prevention gaps.
Exchange transfusion remains the definitive treatment for severe neonatal hyperbilirubinaemia; yet its aetiology and outcomes in rural tropical settings are poorly characterised. This five-year retrospective analysis of 58 neonates at a North Indian rural tertiary centre reveals that Rh incompatibility accounted for 76% of cases - a striking divergence from high income-country patterns where ABO incompatibility predominates - indicating critical gaps in antenatal Rh immuno-prophylaxis. The procedure achieved a mean bilirubin reduction of 50% (424 ± 106 to 212 ± 70&mu/L, p < 0.001) with no procedure-related mortality, though clinically significant adverse events occurred in 19% of neonates. Notably, 10.2% presented with acute bilirubin encephalopathy at the time of intervention, representing potentially preventable neurological injury. These findings make a compelling case for urgent, systematic improvements in antenatal screening, Rh immuno-prophylaxis access, and early jaundice recognition in tropical resource-limited settings.
Computer-aided diagnosis of neonatal acute bilirubin encephalopathy with multi-modal MRI images and convolutional neural networks.
Acute bilirubin encephalopathy (ABE) is a serious complication of hyperbilirubinemia (HB). Efficiently detecting ABE in non-ABE neonates with HB by magnetic resonance imaging (MRI) techniques remains a great challenge in clinical practice, as both groups may exhibit similar MRI features of T1 hyperintensity in specific brain regions. To this end, a computer-aided (CAD) diagnosis system based on multi-modal MRI images and convolutional neural networks (CNNs) was proposed in this study. A total of 150 patients were included in the study, half of whom were ABE neonates, and the other half were non-ABE neonates with HB. During the hospitalization, each patient underwent a 3 Tesla whole-brain MRI examination, generating a T1-weighted image (T1WI), a T2-weighted image (T2WI), and an apparent diffusion coefficient map (ADC), respectively. These 3 types of MRI images and their combinations were fed into 2 CNNs, i.e., EfficientNetB0 and InceptionV3. A traditional machine learning method, as a baseline, named support vector machine was also applied and its performance was then compared with CNNs. The classifiers’ performance with multi-modal MRI images was superior to that with any single-modal MRI image. Both 2 CNNs outperformed SVM. The best performance was achieved by InceptionV3 with the fusion images of T1WI, T2WI, and ADC, with an accuracy of 0.9622 AUC of 0.9978, and F1-score of 0.9617. The proposed CAD system for automatically diagnosing neonatal ABE based on multi-modal MRI images and CNNs showed an outstanding performance and is potentially applicable in actual clinical practice.
High- versus low-dose phototherapy for neonatal jaundice.
Phototherapy is the mainstay of treatment for neonatal hyperbilirubinaemia. Increasing the dosage or intensity of phototherapy by various means is commonly practised for infants with high levels of serum bilirubin. It is unclear whether these measures of increasing phototherapy dosage are beneficial and safe for neonates. To assess the effects of high-dose versus low-dose phototherapy on bilirubin level and associated clinical outcomes that constitute the major conditions in kernicterus spectrum disorder (KSD), such as acute bilirubin encephalopathy and kernicterus, as well as cerebral palsy and neurodevelopmental disabilities in infants with hyperbilirubinaemia; and to assess the effects of high-dose phototherapy, defined as the use of high levels of measured spectral irradiance greater than 30 μW/cm²/nm over the same bandwidth, as well as low-dose phototherapy, defined as measured levels of spectral irradiance below 30 μW/cm²/nm. Searches were conducted up to 09 June 2025 in MEDLINE, Embase, CENTRAL, and two trial registries. We checked reference lists of related reviews and included studies. We included randomised controlled trials (RCTs), quasi-RCTs and clustered RCTs of term (≥ 37 weeks' gestation) and preterm (˂ 37 weeks' gestation) infants with hyperbilirubinaemia, and requiring any type of phototherapy. We compared high- to low-dose phototherapy. High- and low-dose phototherapy are achieved in various ways: by the use of multiple devices; different levels of light intensity (irradiance); or positioning of the devices closer to the skin. We compared these different methods of delivering phototherapy to each other. We specified no exclusion criteria for the infants. We excluded cross-over studies. Our critical outcomes were incidence of acute bilirubin encephalopathy and kernicterus, the proportion of infants with moderate or severe cerebral palsy, all-cause mortality before discharge and serum bilirubin levels at the latest periods of measurements, which included 24, 48 and 72 hours after treatment commencement. We used the Cochrane RoB 2 tool to assess bias in the RCTs. We synthesised results for each outcome with data using meta-analysis, where possible, with a random-effects model. For outcomes with a high degree of heterogeneity, we explored study characteristics and performed meta-regression. We used GRADE to assess the certainty of evidence for critical and selected important outcomes. We included 41 studies (6927 infants) of preterm, late preterm and term gestations with different birth weights. The phototherapy treatment in the studies lasted from 16 to 60 hours. Thirty-four studies were parallel RCTs, six were quasi-RCTs and one had unclear allocation methods. The studies were published between 1972 and 2025 and conducted in 21 lower-, lower-middle, upper-middle and high-income countries. Thirty-eight studies (n = 6508) contributed data to the meta-analysis. We identified one ongoing study. A single overall comparison of high-versus low-dose phototherapy was evaluated with various means of achieving high and low dosages. One-third of the studies had a high risk of bias, and another third had some concerns about the randomisation process, while most studies had low risk of bias in all the other domains. There was a very high degree of heterogeneity in several outcomes, including serum bilirubin levels at various time points, which was inadequately explained and resulted in the downgrading of evidence certainty. Evidence certainty was also downgraded for imprecision for the critical outcomes of the incidence of acute bilirubin encephalopathy, proportions with moderate-to-severe cerebral palsy and all-cause mortality before hospital discharge. From a single study, no infants developed acute bilirubin encephalopathy (Not estimable; 1 study, 80 participants; very low-certainty evidence) and no studies assessed kernicterus. It is very uncertain whether high-dose phototherapy reduces moderate or severe cerebral palsy (RR 0.69, 95% CI 0.46 to 1.02; I² = 0%; 2 studies, 1927 participants; very low-certainty evidence). High-dose phototherapy may result in little to no difference in all-cause mortality before hospital discharge (RR 1.05, 95% CI 0.89 to 1.23; I² = 0%; 2 studies, 1985 participants; low-certainty evidence). High-dose phototherapy may result in a small reduction in serum bilirubin (in micromol/L) at 24 and 48 hours after commencement: at 24 hours (MD -22.76, 95% CI -32.02 to -13.50; I² = 97%; 35 studies, 5025 participants; low-certainty evidence); at 48 hours (MD -23.63, 95% CI -40.76 to -6.50; I² = 91%; 8 studies, 776 participants; low-certainty evidence), with very uncertain effects at 72 hours (MD -9.00, 95% CI -19.53 to 1.53; I² not applicable; 1 study, 144 participants; very low-certainty evidence). The low- to very low-certainty evidence precluded firm conclusions about the effects of high-dose compared to low-dose phototherapy on acute bilirubin encephalopathy, moderate or severe cerebral palsy and all-cause mortality. No studies evaluated kernicterus. It is unclear how small reductions in serum bilirubin at 12 to 48 hours translate to clinically important benefits. Further RCTs with robust randomisation methods and detailed documentation of population and intervention, with inclusion of patient-important outcomes are needed to improve the certainty of the evidence. This Cochrane review had no dedicated funding. Protocol (2001) DOI: 10.1002/14651858.CD0033; Protocol (2020) DOI: 10.1002/14651858.CD003308.pub2.
Evidence That Cerebral Visual Impairment May Evolve after Initial Brain Injury.
An initial insult to an infant’s developing brain can set off a chain reaction. This singular, damaging CNS event can cause subsequent injuries to the extrastriate cortex, which manifest later in childhood.
Filtered-sunlight phototherapy for newborns with moderate-to-severe hyperbilirubinemia: a randomized trial.
Filtered-sunlight phototherapy (FSPT) is safe and non-inferior to conventional phototherapy for treating mild-to-moderate hyperbilirubinemia during birth hospitalization. We evaluated the performance of FSPT among newborns with moderate-to-severe hyperbilirubinemia. Newborns were randomized to FSPT or intensive electric phototherapy (IEPT). Primary outcomes were safety, defined as the absence of hyperthermia, hypothermia, dehydration, or sunburn; and efficacy, defined as the rate of increase in total serum or plasma bilirubin (TSB) < 3.4 µmol/L/h for newborns aged ≤72 h or a decrease in TSB for newborns aged >72 h who received ≥4 h of phototherapy. Secondary outcomes were night-time phototherapy, exchange transfusion (ET), and neonatal mortality rates. Some 104 newborns were assigned to FSPT (n = 52) or IEPT (n = 52). Mean irradiance was 27.7 ± 7.3μW/cm²/nm under FSPT and 36.1 ± 8.3μW/cm²/nm under IEPT. FSPT and IEPT were 93.4% and 93.3% efficacious in all treatment days, respectively. No newborn developed controlled hyperthermia or met the criteria for withdrawal for safety reasons under FSPT. Night-time phototherapy was more frequent under FSPT (52.5%) than IEPT (43.4%). Three neonates (FSPT = 2 and IEPT = 1) had ET. No baby died. Where practicable, FSPT is safe and non-inferior to IEPT for treating neonates with moderate-to-severe hyperbilirubinemia during birth hospitalization when there is no effective IEPT. NCT02612727 (24/11/2015). Filtered-sunlight phototherapy (FSPT) is safe and efficacious for treating newborns with moderate-to-severe hyperbilirubinemia during birth hospitalization. Compared to intensive electric phototherapy, FSPT is not associated with higher rates of exchange transfusion or mortality. The incidence of hazardous hyperbilirubinemia with or without acute bilirubin encephalopathy is rare within 72 h of life in a population with high prevalence of G6PD deficiency and ABO incompatibility risk. In settings where intensive electric phototherapy that meets the recommended minimum irradiance threshold of 30 μW/cm²/nm cannot be assured, FSPT should be considered for at least 4 h for newborns with moderate-to-severe hyperbilirubinemia when practicable.
Publicações recentes
Predominance of Rh-mediated haemolytic disease driving exchange transfusions in rural north India: A five-year retrospective analysis revealing critical prevention gaps.
Computer-aided diagnosis of neonatal acute bilirubin encephalopathy with multi-modal MRI images and convolutional neural networks.
High- versus low-dose phototherapy for neonatal jaundice.
Evidence That Cerebral Visual Impairment May Evolve after Initial Brain Injury.
Diagnosing acute bilirubin encephalopathy in neonates using MRI-based deep learning model.
📚 EuropePMC53 artigos no totalmostrando 129
Predominance of Rh-mediated haemolytic disease driving exchange transfusions in rural north India: A five-year retrospective analysis revealing critical prevention gaps.
Tropical doctorComputer-aided diagnosis of neonatal acute bilirubin encephalopathy with multi-modal MRI images and convolutional neural networks.
Scientific reportsHigh- versus low-dose phototherapy for neonatal jaundice.
The Cochrane database of systematic reviewsEvidence That Cerebral Visual Impairment May Evolve after Initial Brain Injury.
OphthalmologyDiagnosing acute bilirubin encephalopathy in neonates using MRI-based deep learning model.
BMC pediatricsFiltered-sunlight phototherapy for newborns with moderate-to-severe hyperbilirubinemia: a randomized trial.
Pediatric researchQuality Improvement Reduces Excessive Serum Bilirubin Laboratory Draws in a Community Hospital Nursery.
Hospital pediatricsDetecting acute bilirubin encephalopathy in neonates based on multimodal MRI images and non-image clinical data.
BMC pediatricsEffect of education program regarding pathological jaundice on nurses' performance and neonates' bilirubin-induced neurological dysfunction.
European journal of pediatricsShrill cry, opisthotonus, and sun setting sign in a yellow neonate.
Tropical doctorReal-world use of the CarestartTM glucose-6-phosphate dehydrogenase rapid diagnostic test to determine G6PD deficiency in Nigerian neonates.
Journal of tropical pediatricsHeliotherapy for neonates with severe-to-hazardous hyperbilirubinemia: a randomized controlled, non-inferiority trial.
Scientific reportsAssessment of Knowledge and Attitudes of Parents Regarding Neonatal Jaundice in Abia State Children's Specialist Hospital, Umuahia, Nigeria: A Cross-Sectional Study.
CureusResolution of Canine Acute Bilirubin Encephalopathy and Immune-Mediated Hemolytic Anemia Following Four Plasmapheresis Treatments.
Journal of the American Animal Hospital AssociationExchange Transfusion Trends and Risk Factors for Extreme Neonatal Hyperbilirubinemia over 10 Years in Shiraz, Iran.
Iranian journal of medical sciencesManagement of Neonatal Hyperbilirubinemia: Shedding Light on the American Academy of Pediatrics 2022 Clinical Practice Guideline Revision.
Pediatric annalsDynamic whole-transcriptome landscape of acute bilirubin encephalopathy in newborns.
Journal of pharmaceutical and biomedical analysisTranscutaneous bilirubinometry for detecting jaundice in term or late preterm neonates.
The Cochrane database of systematic reviewsMore than Meets the Eye: Exchange Transfusion in Neonates with Acute Bilirubin Encephalopathy.
The Journal of pediatricsExchange Transfusions in Late Preterm and Term Neonates with Acute Bilirubin Encephalopathy.
The Journal of pediatricsEffectiveness of phototherapy with and without probiotics for the treatment of indirect hyperbilirubinaemia in preterm neonates: a randomised controlled trial.
Paediatrics and international child healthUnbound Bilirubin and Acute Bilirubin Encephalopathy in Infants Born Late Preterm and Term with Significant Hyperbilirubinemia.
The Journal of pediatricsDemystifying non-invasive approaches for screening jaundice in low resource settings: a review.
Frontiers in pediatricsAntenatal jaundice instruction and acute bilirubin encephalopathy in Nigeria.
Pediatric researchMagnetic resonance spectroscopy and auditory brain-stem response audiometry as predictors of bilirubin-induced neurologic dysfunction in full-term jaundiced neonates.
European journal of pediatricsGlobus pallidus/putamen T1WI signal intensity ratio in grading and predicting prognosis of neonatal acute bilirubin encephalopathy.
Frontiers in pediatricsAutomated ABR screening for hearing loss and its clinical determinants among newborns with hyperbilirubinemia in National Hospital, Abuja, Nigeria.
Nigerian journal of clinical practiceProspective cohort study of neurodevelopmental outcomes following extreme neonatal hyperbilirubinaemia in Australia.
Journal of paediatrics and child healthPredictive and diagnostic measures for kernicterus spectrum disorder: a prospective cohort study.
Pediatric researchThe differential value of radiomics based on traditional T1-weighted sequences in newborns with hyperbilirubinemia.
BMC medical imagingRetracted: Establishment and Evaluation of Influencing Factors and Risk Prediction Model of Severe Neonatal Hyperbilirubinemia Complicated with Acute Bilirubin Encephalopathy.
Evidence-based complementary and alternative medicine : eCAMThe use of transcutaneous bilirubin nomograms for the prevention of bilirubin neurotoxicity in the neonates.
Frontiers in public healthEtiology analysis and G6PD deficiency for term infants with jaundice in Yangjiang of western Guangdong.
Frontiers in pediatricsGlobal Prevalence of Severe Neonatal Jaundice among Hospital Admissions: A Systematic Review and Meta-Analysis.
Journal of clinical medicineDeep Learning Network with Spatial Attention Module for Detecting Acute Bilirubin Encephalopathy in Newborns Based on Multimodal MRI.
Diagnostics (Basel, Switzerland)Diagnostics Value of Quantitative Magnetic Resonance Imaging (MRI) in Neonatal Acute Bilirubin Encephalopathy.
Journal of child neurologyImaging of nerve injury in neonatal acute bilirubin encephalopathy using 1H-MRS and Glu-CEST techniques.
Frontiers in neuroscienceIncidence and risk factors of acute bilirubin encephalopathy in neonates with hyperbilirubinemia presenting at secondary care hospital.
Pakistan journal of medical sciencesDevelopment and evaluation clinical-radiomics analysis based on T1-weighted imaging for diagnosing neonatal acute bilirubin encephalopathy.
Frontiers in neurologyBetter assessment of neonatal jaundice at home (BEAT Jaundice @home): protocol for a prospective, multicentre diagnostic study.
BMJ openCorrigendum: Analysis on the MRI and BAEP results of neonatal brain with different levels of bilirubin.
Frontiers in pediatricsA Metadecomposition of Clinical Value Assessed Using aEEG in Severe Neonatal Hyperbilirubinemia.
Contrast media & molecular imagingDeterminants of neonatal jaundice in Ethiopia: a systematic review and meta-analysis.
World journal of pediatrics : WJPRole of transcranial Doppler in assessment of cerebral blood flow in full term neonates with extreme unconjugated hyperbilirubinemia.
Journal of ultrasoundEstablishment and Evaluation of Influencing Factors and Risk Prediction Model of Severe Neonatal Hyperbilirubinemia Complicated with Acute Bilirubin Encephalopathy.
Evidence-based complementary and alternative medicine : eCAMBilirubin Encephalopathy.
Current neurology and neuroscience reportsIntravenous Immunoglobulin Use in Hemolytic Disease Due to ABO Incompatibility to Prevent Exchange Transfusion.
Frontiers in pediatricsClinical Assessment of Neuroinflammatory Markers and Antioxidants in Neonates with Hyperbilirubinemia and Their Association with Acute Bilirubin Encephalopathy.
Children (Basel, Switzerland)Trends and Resource Utilization for Neonatal Jaundice Hospitalizations in the United States.
Hospital pediatricsAnalysis on the MRI and BAEP Results of Neonatal Brain With Different Levels of Bilirubin.
Frontiers in pediatricsNeonatal hyperbilirubinemia: recommendations for diagnosis and management in the emergency department.
Pediatric emergency medicine practiceHigh levels of pathological jaundice in the first 24 hours and neonatal hyperbilirubinaemia in an epidemiological cohort study on the Thailand-Myanmar border.
PloS oneHigh levels of unbound bilirubin are associated with acute bilirubin encephalopathy in post-exchange transfusion neonates.
Italian journal of pediatricsMagnetic Resonance Image of Neonatal Acute Bilirubin Encephalopathy: A Diffusion Kurtosis Imaging Study.
Frontiers in neurologyPattern of serum bilirubin changes following double volume exchange blood transfusion in neonates at a tertiary health facility in Nigeria.
The Pan African medical journalExchange transfusion for neonatal hyperbilirubinemia: A multicenter, prospective study of Turkish Neonatal Society.
Turkish archives of pediatricsSunlight for the prevention and treatment of hyperbilirubinemia in term and late preterm neonates.
The Cochrane database of systematic reviewsAmplitude of low-frequency fluctuation may be an early predictor of delayed motor development due to neonatal hyperbilirubinemia: a fMRI study.
Translational pediatricsDetecting neonatal acute bilirubin encephalopathy based on T1-weighted MRI images and learning-based approaches.
BMC medical imagingDetecting acute bilirubin encephalopathy in neonates based on multimodal MRI with deep learning.
Pediatric researchChildhood neurodevelopmental outcomes of survivors of acute bilirubin encephalopathy: A retrospective cohort study.
Early human developmentAmplitude-integrated electroencephalography improves the predictive ability of acute bilirubin encephalopathy.
Translational pediatricsKnowledge, Observation and Practices Related to Neonatal Jaundice in a Rural Community in Kano, Nigeria.
Journal of tropical pediatricsEarly Neurodevelopmental Outcome of Neonates with Gestation 35 Weeks or More with Serum Bilirubin in Exchange Range Without Encephalopathy: A Prospective Observational Study.
Neonatal network : NNEconomic evaluation of point of care universal newborn screening for glucose-6-Phosphate dehydrogenase deficiency in United States.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal ObstetriciansNeonatal Severe Hyperbilirubinemia Online Registry in Jiangsu Province: protocol for a multicentre, prospective, open, observational cohort study.
BMJ openHyperbilirubinemia in Preterm Infants Admitted to Neonatal Intensive Care Units in Ethiopia.
Global pediatric healthNomogram for Acute Bilirubin Encephalopathy Risk in Newborns With Extreme Hyperbilirubinemia.
Frontiers in neurologyAcute bilirubin encephalopathy: Some lessons learned.
Seminars in perinatologyBIND score: A system to triage infants readmitted for extreme hyperbilirubinemia.
Seminars in perinatology[Remote monitoring of neonatal jaundice in newborns with ABO hemolytic disease].
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciencesTraditional African remedies induce hemolysis in a glucose-6-phopshate dehydrogenase deficient zebrafish model.
Scientific reportsExchange blood transfusion in neonates with severe hyperbilirubinemia in a lower-middle-income country: can we minimise the incidence?
Tropical doctorAcute bilirubin encephalopathy and its associated risk factors in a tertiary care hospital, Pakistan.
Pakistan journal of medical sciencesGlucose-6-Phosphate Dehydrogenase Deficiency and the Benefits of Early Screening.
Neonatal network : NN[An investigation of severe neonatal hyperbilirubinemia in 13 hospitals of Jiangsu Province, China].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatricsCombating the Hidden Health Disparity of Kernicterus in Black Infants: A Review.
JAMA pediatricsExtreme neonatal hyperbilirubinaemia in refugee and migrant populations: retrospective cohort.
BMJ paediatrics openEarly prediction of adverse outcomes in infants with acute bilirubin encephalopathy.
Annals of clinical and translational neurologyQuantitative proteomic characterization of microvesicles/exosomes from the cerebrospinal fluid of patients with acute bilirubin encephalopathy.
Molecular medicine reportsSupporting Breastfeeding in Infants Hospitalized for Jaundice.
Hospital pediatricsInfants affected by Rh sensitization: A 2-year Canadian National Surveillance Study.
Paediatrics & child healthMaternal Instruction About Jaundice and the Incidence of Acute Bilirubin Encephalopathy in Nigeria.
The Journal of pediatricsA clinical prediction rule for acute bilirubin encephalopathy in neonates with extreme hyperbilirubinemia: A retrospective cohort study.
MedicineManagement of neonatal jaundice in low- and middle-income countries.
Paediatrics and international child healthSevere neonatal hyperbilirubinemia in the southeast region of Turkey.
Turkish journal of medical sciencesMachine Learning Assisted MRI Characterization for Diagnosis of Neonatal Acute Bilirubin Encephalopathy.
Frontiers in neurologyReview of bilirubin neurotoxicity II: preventing and treating acute bilirubin encephalopathy and kernicterus spectrum disorders.
Pediatric researchA Gunn rat model of preterm hyperbilirubinemia.
Pediatric researchPrebiotics for the prevention of hyperbilirubinaemia in neonates.
The Cochrane database of systematic reviewsSuccessful management of acute bilirubin encephalopathy in a dog with immune-mediated hemolytic anemia using therapeutic plasma exchange.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)Early Amplitude-Integrated Electroencephalography Predicts Long-Term Outcomes in Term and Near-Term Newborns With Severe Hyperbilirubinemia.
Pediatric neurologyTurkish Neonatal Society guideline to the approach, follow-up, and treatment of neonatal jaundice.
Turk pediatri arsiviThe Neonatal Acute Bilirubin Encephalopathy Registry (NABER): Background, Aims, and Protocol.
NeonatologyA Novel Whole Spectrum-Based Non-Invasive Screening Device for Neonatal Hyperbilirubinemia.
IEEE journal of biomedical and health informaticsCharacteristics and outcome of newborn admitted with acute bilirubin encephalopathy to a tertiary neonatal intensive care unit.
World journal of pediatrics : WJPNeonatal hyperbilirubinaemia: a global perspective.
The Lancet. Child & adolescent healthPrevalence of Hearing Impairment Among High-Risk Newborns in Ibadan, Nigeria.
Frontiers in pediatricsEmergency release uncross-matched packed red blood cells for immediate double volume exchange transfusion in neonates with intermediate to advanced acute bilirubin encephalopathy: timely but insufficient?
Journal of perinatology : official journal of the California Perinatal AssociationExtreme neonatal hyperbilirubinemia, acute bilirubin encephalopathy, and kernicterus spectrum disorder in children with galactosemia.
Pediatric researchAcute neonatal bilirubin encephalopathy in the State of Utah 2009-2018.
Blood cells, molecules & diseasesBurden of severe neonatal jaundice: a systematic review and meta-analysis.
BMJ paediatrics openPatterns of acute bilirubin encephalopathy in Nigeria: a multicenter pre-intervention study.
Journal of perinatology : official journal of the California Perinatal AssociationThe Neuroprotective Effects of Hypothermia on Bilirubin-Induced Neurotoxicity in vitro.
NeonatologyA nurse-initiated jaundice management protocol improves quality of care in the paediatric emergency department.
Paediatrics & child healthThe Turkish Neonatal Jaundice Online Registry: A national root cause analysis.
PloS oneEvaluation of transcutaneous bilirubinometer (DRAEGER JM 103) use in Zimbabwean newborn babies.
Maternal health, neonatology and perinatologyMaternal Empowerment - An Underutilized Strategy to Prevent Kernicterus?
Current pediatric reviewsSevere neonatal hyperbilirubinaemia is frequently associated with long hospitalisation for emergency care in Nigeria.
Acta paediatrica (Oslo, Norway : 1992)The Neurological Sequelae of Neonatal Hyperbilirubinemia: Definitions, Diagnosis and Treatment of the Kernicterus Spectrum Disorders (KSDs).
Current pediatric reviewsReport about term infants with severe hyperbilirubinemia undergoing exchange transfusion in Southwestern China during an 11-year period, from 2001 to 2011.
PloS oneFollow-up of Children with Kernicterus in Kano, Nigeria.
Journal of tropical pediatricsA neurologic dysfunction scoring protocol for jaundiced neonates requiring exchange transfusion.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal ObstetriciansSpectrum and outcome of neonatal emergencies seen in a free health-care program in South-Western Nigeria.
Nigerian journal of clinical practicePrediction of 3- to 5-Month Outcomes from Signs of Acute Bilirubin Toxicity in Newborn Infants.
The Journal of pediatricsBilirubin-Induced Neurotoxicity in the Preterm Neonate.
Clinics in perinatologyFacility-based constraints to exchange transfusions for neonatal hyperbilirubinemia in resource-limited settings.
World journal of clinical pediatricsMagnetic Resonance Imaging Abnormalities in Advanced Acute Bilirubin Encephalopathy Highlight Dentato-Thalamo-Cortical Pathways.
The Journal of pediatricsHeliotherapy for Neonatal Hyperbilirubinemia in Southwest, Nigeria: A Baseline Pre-Intervention Study.
PloS oneA decision-making tool for exchange transfusions in infants with severe hyperbilirubinemia in resource-limited settings.
Journal of perinatology : official journal of the California Perinatal AssociationPredictors of Repeat Exchange Transfusion for Severe Neonatal Hyperbilirubinemia.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care SocietiesThe burden and management of neonatal jaundice in Nigeria: A scoping review of the literature.
Nigerian journal of clinical practiceRevisiting the Criteria for Exchange Transfusion for Severe Neonatal Hyperbilirubinemia in Resource-Limited Settings.
NeonatologySpontaneous improvement in sensorineural hearing loss developed as a complication of neonatal hyperbilirubinemia.
JPMA. The Journal of the Pakistan Medical AssociationManagement of late-preterm and term infants with hyperbilirubinaemia in resource-constrained settings.
BMC pediatricsA modified Bilirubin-induced neurologic dysfunction (BIND-M) algorithm is useful in evaluating severity of jaundice in a resource-limited setting.
BMC pediatricsParoxysmal nonepileptic motor phenomena in newborn.
Brain & developmentGalactosaemia: an unusual cause of chronic bilirubin encephalopathy.
BMJ case reportsRisk factors for acute bilirubin encephalopathy on admission to two Myanmar national paediatric hospitals.
Maternal health, neonatology and perinatologyAssociações
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Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Predominance of Rh-mediated haemolytic disease driving exchange transfusions in rural north India: A five-year retrospective analysis revealing critical prevention gaps.
- Computer-aided diagnosis of neonatal acute bilirubin encephalopathy with multi-modal MRI images and convolutional neural networks.
- High- versus low-dose phototherapy for neonatal jaundice.
- Evidence That Cerebral Visual Impairment May Evolve after Initial Brain Injury.
- Filtered-sunlight phototherapy for newborns with moderate-to-severe hyperbilirubinemia: a randomized trial.
- Diagnosing acute bilirubin encephalopathy in neonates using MRI-based deep learning model.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:529799(Orphanet)
- MONDO:0035344(MONDO)
- GARD:22197(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
