Raras
Buscar doenças, sintomas, genes...
Encefalite disseminada aguda
ORPHA:83597CID-10 · G04.0CID-11 · 8A42DOENÇA RARA

A Encefalomielite Disseminada Aguda (ADEM) é uma doença inflamatória do sistema nervoso central que surge de repente, afeta o cérebro e a medula espinhal em várias áreas e causa a destruição da mielina, a camada protetora dos nervos.

Mantido por Agente Raras·Colaborar como especialista →

Introdução

O que você precisa saber de cara

📋

A Encefalomielite Disseminada Aguda (ADEM) é uma doença inflamatória do sistema nervoso central que surge de repente, afeta o cérebro e a medula espinhal em várias áreas e causa a destruição da mielina, a camada protetora dos nervos.

Pesquisas ativas
11 ensaios
15 total registrados no ClinicalTrials.gov
Publicações científicas
2.521 artigos
Último publicado: 2026 Mar

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
Unknown
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Início
All ages
🏥
SUS: Cobertura mínimaScore: 15%
CID-10: G04.0
🇧🇷Dados SUS / DATASUS
PROCEDIMENTOS SIGTAP (2)
0202010694
Sequenciamento completo do exoma (WES)genetic_test
0301070040
Atendimento em reabilitação — doenças rarasrehabilitation
Você se identifica com essa condição?
O Raras está aqui pra te apoiar — com ou sem diagnóstico

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🧠
Neurológico
10 sintomas
🛡️
Imunológico
3 sintomas
👁️
Olhos
3 sintomas
🫃
Digestivo
3 sintomas
❤️
Coração
1 sintomas
🩸
Sangue
1 sintomas

+ 31 sintomas em outras categorias

Características mais comuns

100%prev.
Encefalopatia
90%prev.
EEG com atividade lenta generalizada
Muito frequente (99-80%)
90%prev.
Desmielinização do SNC
Muito frequente (99-80%)
90%prev.
Anormalidades difusas da substância branca
Muito frequente (99-80%)
55%prev.
Hipersonia
55%prev.
Sonolência diurna excessiva
Frequente (79-30%)
54sintomas
Muito frequente (4)
Frequente (24)
Ocasional (17)
Muito raro (9)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 54 características clínicas mais associadas, ordenadas por frequência.

EncefalopatiaEncephalopathy
Muito frequente100%
EEG com atividade lenta generalizadaEEG with generalized slow activity
Muito frequente (99-80%)90%
Desmielinização do SNCCNS demyelination
Muito frequente (99-80%)90%
Anormalidades difusas da substância brancaDiffuse white matter abnormalities
Muito frequente (99-80%)90%
HipersoniaHypersomnia
Frequente55%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico2.521PubMed
Últimos 10 anos200publicações
Pico2025115 papers
Linha do tempo
2026Hoje · 2026🧪 1995Primeiro ensaio clínico📈 2025Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
3Fase 31
·Pré-clínico14
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 15 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Encefalite disseminada aguda

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

8 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

Outros ensaios clínicos

15 ensaios clínicos encontrados, 11 ativos.

Distribuição por fase
Ver todos no ClinicalTrials.gov
🧪 Está conduzindo uma pesquisa?
Divulgue para pacientes e familiares que acompanham esta doença.
Divulgar pesquisa →

Publicações mais relevantes

Timeline de publicações
1.339 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 1.339

#1

Postmarketing safety surveillance for GSK's AS01E-adjuvanted respiratory syncytial virus prefusion F protein-based vaccine in the USA: protocol for a non-interventional postauthorisation safety study.

BMJ open2026 Mar 19

In May 2023, the US Food and Drug Administration (FDA) initially approved an AS01E-adjuvanted respiratory syncytial virus (RSV) prefusion F protein-based vaccine (adjuvanted RSVPreF3) for adults aged ≥60 years. The approval was expanded in June 2024 to include adults 50-59 years of age at increased risk for RSV-associated lower respiratory tract disease. In this paper, we describe the protocol of a postmarketing safety study evaluating the association between adjuvanted RSVPreF3 and new-onset Guillain-Barré syndrome (GBS), acute disseminated encephalomyelitis (ADEM) and atrial fibrillation (AF) among adults ≥50 years of age in the USA and provide our rationale for key methodological decisions. The potential associations between adjuvanted RSVPreF3 and GBS, ADEM and AF will be evaluated using secondary healthcare data and the self-controlled risk interval (SCRI) design. Data from five research partners in the USA spanning August 2023 through June 2030 will be used for the conduct of yearly monitoring queries and, sample size permitting, SCRI analyses. Claims-based definitions for new-onset outcomes (first diagnosis in 365 days) are: ≥1 inpatient diagnosis for GBS and ADEM; ≥1 inpatient or ≥2 ambulatory/emergency diagnoses for AF. The primary risk and control windows are 1-42 and 43-84 days, respectively, for GBS and ADEM; and 1-8 and 9-16 days for AF. SCRI analyses for GBS and ADEM will include chart-confirmed cases. SCRI analyses for AF will adjust for the positive predictive value obtained from validation against charts. Conditional Poisson regression will be used to calculate incidence rate ratios. This study was approved by the Institutional Review Boards (IRB) of Harvard Pilgrim Health Care Institute; WIRB-Copernicus Group, Inc and its affiliates (collectively, 'WCG'); WCG IRB, Inc; and Sterling IRB, with Federal Wide Assurance (FWA) numbers FWA00000100, FWA00033319 and FWA00025632, respectively, for all participating research partners. Study results will be shared with the US FDA and publicly disseminated through national or international clinical or scientific conferences and peer-reviewed publications. This protocol has been registered in the Heads of Medicines Agencies-European Medicines Agency Real World Data Catalogues (EUPAS1000000486).

#2

Acute Disseminated Encephalomyelitis (ADEM): Current View into Etiopathogenesis and Clinical Features.

Brain sciences2026 Feb 09

Acute disseminated encephalomyelitis (ADEM) is a rare, immune-mediated demyelinating disorder of the central nervous system (CNS) that predominantly affects children and young adults. ADEM typically follows an infectious or, less commonly, immunization-related trigger, and despite decades of clinical observation, its etiopathogenesis remains only partially understood. Clinically, the diagnosis of ADEM continues to pose significant challenges due to the absence of disease-specific biomarkers and its clinical and radiological overlap with other acquired demyelinating syndromes. This narrative review aims to summarize and critically discuss current knowledge on ADEM, with particular emphasis on its etiopathogenesis and clinical characteristics, highlighting the potential implications of recent research for clinical practice and management of this disease. Particular emphasis is placed on post-infectious immune mechanisms, including molecular mimicry, blood-brain barrier (BBB) disruption, loss of immune tolerance, and neuroinflammatory cascades. A wide spectrum of infectious triggers-viral, bacterial, parasitic-as well as post-vaccination, post-transplantation, paraneoplastic, metabolic, and host-related genetic factors are discussed in the context of immune dysregulation leading to CNS demyelination. We also highlight characteristic clinical and neuroimaging features that may aid in differentiating ADEM from other demyelinating syndromes, while acknowledging current diagnostic limitations. The integration of recent advances in ADEM immunopathogenesis with established clinical and radiological insights underscores the complexity of this disorder and highlights the evolving nature of current concepts regarding its diagnosis and clinical heterogeneity.

#3

Natural experiment on neuroinflammatory disease incidence and infection links pre- and post-COVID-19.

Brain : a journal of neurology2026 Mar 05

Infections are recognized triggers for several neuroinflammatory disorders. The coronavirus disease 2019 (COVID-19) pandemic's non-pharmaceutical interventions sharply curtailed pathogen exposure, creating a natural experiment to test infection-disease links. Using Japan's National Claims Database, we first validated the nationwide decline with two strictly infection-dependent conditions-epidemic keratoconjunctivitis and influenza-associated encephalopathy-whose monthly incidences fell by >60% after April 2020. Next, we applied an interrupted time series design, a causal-inference method for longitudinal data, to nine immune-mediated inflammatory diseases. Unsupervised clustering of model-derived level and slope changes identified three data-driven clusters. The first cluster, comprising Guillain-Barré syndrome and acute disseminated encephalomyelitis, showed large, statistically significant level reductions (P < 0.001), particularly in women, consistent with infection-susceptible pathophysiology. The second cluster, including myasthenia gravis and optic neuritis, exhibited transient declines followed by significant positive post-intervention slopes (P < 0.001), suggesting deferred diagnosis, treatment interruption or immune rebound. The third cluster, consisting of sarcoidosis, neuromyelitis optica, multiple sclerosis, Vogt-Koyanagi-Harada disease and Behçet's disease, remained stable, suggesting limited or complex infectious links. These data-driven trajectories mirror clinical pathophysiology and demonstrate that reduced pathogen exposure affects neuroinflammatory disease onset to varying degrees. This framework supports infection-related risk stratification, preventive strategies and continuity planning in neuroimmunology practice.

#4

Biomarkers to predict relapse in myelin oligodendrocyte glycoprotein antibody-associated disease: a systematic review and meta-analysis.

Journal of neurology, neurosurgery, and psychiatry2026 Jan 13

Detection of immunoglobulin G targeting myelin oligodendrocyte glycoprotein (MOG-IgG) is the mainstay of laboratory diagnosis of MOG antibody-associated disease. Laboratory biomarkers have the potential to predict disease course and activity, thus informing prompt therapeutic decisions to minimise relapse-associated disability accrual. This systematic review with meta-analysis was registered in PROSPERO (CRD42024554429). MEDLINE, Embase and Scopus databases were searched. Random-effects or mixed-effects modelling was performed and OR or HR with 95% CIs reported. 106 studies with ≥1710 individuals were included. A relapsing course was associated with persistent seropositivity on serial samples collected ≥3 months apart (OR 2.7 (95% CI 1.8 to 4.0), p<0.0001), lower likelihood of seroreversion to negative status (HR 0.19 (95% CI 0.14 to 0.26), p<0.0001) and delayed seroreversion compared with monophasic participants (median 19 years vs 2.5 years, p<0.0001). Acute disseminated encephalomyelitis was associated with a non-relapsing course (OR 0.049 (95% CI 0.0029 to 0.84), p=0.037). Serum MOG-IgG titre-negative, low positive or clear positive-discriminated disease state: attack was associated with clear positive titre (OR 3.6 (95% CI 2.6 to 5.0), p<0.0001), but not negative titre (OR 0.073 (95% CI 0.028 to 0.19), p<0.0001). Cerebrospinal fluid (CSF) leucocytosis (≥5 cells/µL) was associated with attack (OR 3.1 (95% CI 1.7 to 5.9), p=0.0004). Neither serum glial fibrillary acidic protein nor neurofilament light chain correlated with disease activity. Novel biomarkers of disease course and activity have also been assessed qualitatively. MOG-IgG serostatus and titre and CSF leucocytosis are biomarkers of disease course and activity. The findings provide rationale for serial serum MOG-IgG testing at an interval of 3-6 months in the first 12 months of disease to assist in relapse risk stratification. CRD42024554429.

#5

Post malaria neurological syndrome and acute disseminated encephalomyelitis: a case highlighting an ongoing debate.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026 Feb 02

Publicações recentes

Ver todas no PubMed

📚 EuropePMC1.168 artigos no totalmostrando 198

2026

Neuromelioidosis Causing Rapidly Progressing Neurological Syndromes Mimicking Stroke and Demyelination: Insights from a Case Series.

Travel medicine and infectious disease
2026

Feasibility of AI-driven multichannel FES-assisted gait and cycling training in chronic neurological disorders: a case series.

Journal of neuroengineering and rehabilitation
2026

Postmarketing safety surveillance for GSK's AS01E-adjuvanted respiratory syncytial virus prefusion F protein-based vaccine in the USA: protocol for a non-interventional postauthorisation safety study.

BMJ open
2026

Safety monitoring of health outcomes following RSVPreF3 + AS01 and RSVPreF vaccination among Medicare beneficiaries aged 65 years and older in the United States, 2023-2024.

Vaccine
2026

Acute Disseminated Encephalomyelitis (ADEM): Current View into Etiopathogenesis and Clinical Features.

Brain sciences
2026

Clinical response to therapeutic plasma exchange in patients with immune-mediated inflammatory diseases of the central nervous system.

Anales de pediatria
2026

Extensive neurological and functional recovery in an incomplete tetraplegic patient following transverse myelitis/ acute disseminated encephalomyelitis (ADEM) with rehabilitation: a challenging journey of a 17-Year-Old Girl.

Spinal cord series and cases
2026

First demyelinating attack in children: A twelve year single center cohort.

Multiple sclerosis and related disorders
2026

Post-licensure safety surveillance of 9-valent human papillomavirus vaccine using the vaccine adverse event reporting system, 2014-2024.

Frontiers in public health
2026

Post malaria neurological syndrome and acute disseminated encephalomyelitis: a case highlighting an ongoing debate.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2026

Recurrent severe viral infection in a child with inherited complete TBK1 deficiency.

Journal of human immunity
2026

Consensus Recommendations for the Diagnosis and Treatment of Neuromyelitis Optica Spectrum Disorders (NMOSD): The MENACTRIMS Guidelines.

CNS drugs
2025

Case Report: A rare pediatric case of hepatitis B virus infection with acute disseminated encephalomyelitis/Guillain-Barré syndrome spectrum diseases.

Frontiers in pediatrics
2026

Live-Cell-Based Assay Outperforms Fixed Assay in MOGAD Diagnosis: A Retrospective Validation Against the 2023 International Criteria.

Diagnostics (Basel, Switzerland)
2025

Late-onset myelin oligodendrocyte glycoprotein antibody-associated disease: an underrecognized entity in clinical practice; what does its course in later life teach us? A case report and narrative review.

Postepy psychiatrii neurologii
2025

Adult Onset of Type 2 Familial Hemophagocytic Lymphohistiocytosis After SARS-CoV-2 Vaccination with an Unusual Neurological Onset: The Great Mimic.

Diagnostics (Basel, Switzerland)
2025

Clinico‑Radiologic Probable Acute Haemorrhagic Leukoencephalitis Triggered by Legionella Pneumonia.

Cureus
2026

Natural experiment on neuroinflammatory disease incidence and infection links pre- and post-COVID-19.

Brain : a journal of neurology
2025

Pediatric Encephalomyeloradiculoneuropathy With High Lactate in Cerebrospinal Fluid and Magnetic Resonance Spectroscopy: A Case Report.

Journal of child neurology
2026

New-onset autoimmune disease following SARS-CoV-2 infection and mRNA vaccination in Norway: A retrospective cohort study.

Journal of internal medicine
2025

Bilateral thalamic encephalitis due to Epstein-Barr virus in an elderly patient: a case report and literature review.

BMC neurology
2025

Acute ataxia in children: etiological spectrum and clinical characteristics.

Frontiers in pediatrics
2025

Atypical Presentation of Myelin Oligodendrocyte Glycoprotein Antibody Disease as Pyrexia of Unknown Origin with Meningitis: A Case Report.

The Journal of the Association of Physicians of India
2025

Pediatric Neuroinflammatory Disorders: Patterns of Hospital Utilization and Population Burden.

Hospital pediatrics
2025

Acute Hemorrhagic Leukoencephalitis in Pregnancy.

The Neurohospitalist
2025

MRI cortical thickness in paediatric auto-immune encephalitis and acute disseminated encephalomyelitis.

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
2025

Herpes simplex virus type 2 implicated in a case of acute disseminated encephalomyelitis.

Access microbiology
2025

Diagnostic odyssey of opsoclonus-myoclonus syndrome and barriers to early detection.

Brain &amp; development
2025

Hyperperfusion Improvement: A Potential Therapeutic Marker in Neuromyelitis Optica Spectrum Disorder (NMOSD).

Diagnostics (Basel, Switzerland)
2026

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD): Practical recommendations for diagnosis and management.

Journal of neuroimmunology
2025

Silent triggers and symmetric peduncles - a rare presentation of adult-onset acute disseminated encephalomyelitis: A case report.

World journal of clinical cases
2025

Case Report: Autoimmune glial fibrillary acidic protein astrocytopathy complicated with Sjogren's syndrome and recurrent respiratory failure.

Frontiers in immunology
2025

Adult-Onset Acute Disseminated Encephalomyelitis in Elderly Filipino Patients: A Case Report and Review of the Literature.

Cureus
2025

Myelin-oligodendrocyte glycoprotein (MOG) antibody-associated acute disseminated encephalomyelitis (ADEM) in an adult with dengue.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2025

Acute disseminated encephalomyelitis mimicking brain tumor: about 2 pediatric cases: ADEM mimicking brain tumor.

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
2026

Biomarkers to predict relapse in myelin oligodendrocyte glycoprotein antibody-associated disease: a systematic review and meta-analysis.

Journal of neurology, neurosurgery, and psychiatry
2025

Pathophysiology and clinical implications of dengue-associated neurological disorders.

Frontiers in microbiology
2025

Changes in etiology, diagnostic challenges, and prognostic factors in pediatric acute encephalitis: Insights from an 18-year retrospective study.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2025

Case Report: severe Mycoplasma pneumoniae-associated acute disseminated encephalomyelitis in an adult: challenges in diagnosis and management.

Frontiers in medicine
2025

Listeria Brainstem Encephalitis With Myelitis Misdiagnosed as Acute Disseminated Encephalomyelitis:Report of One Case.

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
2025

Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease: Pathophysiology, Clinical Patterns, and Therapeutic Challenges of Intractable and Severe Forms.

International journal of molecular sciences
2025

Potential Causal Relationships Between Circulating Micronutrient Levels and Multiple Neuroimmune Diseases: A Genetic Association Analysis.

Brain and behavior
2025

Hydrocephalus as an Initial Presentation of Myelin Oligodendrocyte Glycoprotein (MOG) Antibody-Associated Disease: A Case Report and Review of Tumor-Mimicking Demyelination.

Cureus
2025

Mid-to long-term disability and functional outcomes in pediatric patients with monophasic acute disseminated encephalomyelitis.

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
2025

Acute symptomatic seizures and epilepsy in pediatric patients with central nervous system inflammatory demyelinating diseases.

Multiple sclerosis and related disorders
2025

Magnetic resonance imaging spectrum of acute hemorrhagic leukoencephalitis: Four case reports.

World journal of clinical cases
2025

Outcomes After Acute Plasma Exchange for Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.

Neurology
2025

[Estimation of pro-inflammatory cytokines and C-reactive protein levels in patients with acute demyelination episode].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
2025

[Highly beneficial outcome in a case of acute hemorrhagic leukoencephalitis (Hurst's encephalitis) treated with methylprednisolone pulse therapy and continuous hemodiafiltration].

Rinsho shinkeigaku = Clinical neurology
2025

Parvovirus B19-Associated Acute Disseminated Encephalomyelitis: A Rare Case with Multiple Cerebral Infarcts and Long-Segment Myelitis.

Annals of Indian Academy of Neurology
2025

Safety monitoring of health outcomes following influenza vaccination during the 2023-2024 season among U.S. Commercially-insured individuals aged 6 months through 64 years: Self-controlled case series analyses.

Vaccine
2025

Neurological manifestations of chronic graft versus host disease.

Internal medicine journal
2025

Application of the ADEM definition to cerebral attacks of MOG antibody-associated disease.

Multiple sclerosis (Houndmills, Basingstoke, England)
2025

Clinical, Radiologic, and Optical Coherence Tomographic Features of Pediatric Acute Disseminated Encephalomyelitis: Comparison of Myelin Oligodendrocyte Glycoprotein Antibody-Positive and -Negative Cases.

Pediatric neurology
2025

Distinct Inflammatory Profiles and Clinical Characteristics of NMOSD: A Comparative Analysis with NMOSD-like and Encephalitis-like MOG-AD.

Journal of proteome research
2025

Current imaging applications, radiomics, and machine learning modalities of CNS demyelinating disorders and its mimickers.

Journal of neurology
2025

Neuroimaging spectrum of myelin oligodendrocyte glycoprotein antibody-associated disease with brain involvement: description of various cerebral syndromes.

Pediatric radiology
2025

Multiphasic acute disseminated encephalomyelitis (MDEM) in a patient with systemic lupus erythematosus and C4A deficiency: case-based review.

Rheumatology international
2025

[Molecular mechanisms of acute disseminated encephalomyelitis].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
2025

Establishing a Multicenter Active Adverse Events Following Immunization Sentinel Surveillance Network Across 22 Tertiary Care Hospitals in India: Protocol for a Prospective Observational Study.

JMIR research protocols
2025

Acute haemorrhagic necrotizing encephalopathy and inflammatory demyelinating encephalopathy associated with COVID-19 in adults in Southern China.

BMC infectious diseases
2025

Clinical Reasoning: A 9-Year-Old Girl With CNS Immune Dysregulation.

Neurology
2025

Prolonged corticosteroid therapy and steroid-sparing maintenance immunotherapy lower relapse risk in pediatric and adult MOGAD.

Journal of neuroimmunology
2025

Autoantibodies against myelin oligodendrocyte glycoprotein in a subgroup of patients with psychotic symptoms.

Frontiers in neurology
2025

Immune checkpoint inhibitor-associated autoimmune encephalitis and other neurological immune-mediated adverse events: a pharmacovigilance study using the FAERS and JADER.

Frontiers in oncology
2024

ADEM as an Initial Presentation of SLE: A Case Report.

Reports (MDPI)
2025

Effects of coronavirus disease 2019 in patients with optic neuritis: a single-centre retrospective cohort study.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2025

Measles Matters: A Clinical Overview and Update.

The Nursing clinics of North America
2025

Interleukin-6 targeting antibodies for the treatment of Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease (MOGAD): A review of current literature.

AIMS neuroscience
2025

COVID-19 vaccines and neurological disorders: A narrative review of immune responses and adverse reactions.

AIMS neuroscience
2025

MOG-IgG detection in serum and cerebrospinal fluid: diagnostic implications and clinical correlates in adult-onset Chinese MOGAD patients.

Journal of neurology
2025

Painless ruptured pyomyoma causing an abdominal abscess in a postmenopausal woman with abdominal hypoesthesia.

The journal of obstetrics and gynaecology research
2025

VEXAS syndrome-associated tumefactive demyelination.

Journal of neurology
2025

Post anti-rabies vaccine encephalitis presenting as acute psychosis: Case reports.

IDCases
2025

Fatal levamisole-associated multifocal inflammatory leukoencephalopathy following levamisole-adulterated cocaine use.

Clinical toxicology (Philadelphia, Pa.)
2025

Relationship between cerebrospinal fluid cytokines/chemokines and clinical impact of myelin oligodendrocyte glycoprotein antibody-associated disorders in children.

Brain &amp; development
2025

Myelin oligodendrocyte glycoprotein antibody-associated cerebral cortical encephalitis: a case report highlighting diagnostic challenges and therapeutic implications.

Frontiers in immunology
2025

Anti-MOG Antibody Associated Disorders in Pakistan.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
2025

Complement factor I deficiency-associated neuroinflammatory disease among Old Order Amish.

The Journal of allergy and clinical immunology
2025

Understanding Mechanisms of Whole Brain and Regional Grey Matter Atrophy in Children With MOGAD.

Annals of clinical and translational neurology
2025

Paediatric Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD): A Case Report With Varied Clinical Manifestations.

Cureus
2025

Uncommon Non-MS Demyelinating Disorders of the Central Nervous System.

Current neurology and neuroscience reports
2026

Association of a giant developmental venous anomaly and acute disseminated encephalomyelitis: A case report and magnetic resonance perfusion study.

The neuroradiology journal
2025

From acute flaccid paralysis (AFP)-Guillain-Barre Syndrome (GBS) and myelitis to progressive encephalopathy : acute disseminated encephalomyelitis (ADEM) atypical presentation of rabies following dog bite.

BMJ case reports
2026

Interleukin-17 family in health and immune diseases: From origin to clinical implications.

Neural regeneration research
2025

French guidelines for the diagnosis and management of MOG antibody-associated disease.

Revue neurologique
2025

A Rare Case of Autoimmune Hemolytic Anemia and Suspected Acute Hemorrhagic Disseminated Encephalomyelitis Following Recent Vaccination.

Cureus
2025

Steroid refractory immune-related acute disseminated encephalomyelitis (ADEM) successfully treated with 2nd and 3rd line immunosuppressive therapy.

BMJ case reports
2025

Translational insights from EAE models : decoding MOGAD pathogenesis and therapeutic innovation.

Frontiers in immunology
2025

Clinical Spectrum of Acquired Demyelinating Syndromes in Children: A Tertiary Hospital Experience.

Neurology and therapy
2025

MOGAD treatment outcomes and relapse characteristics: Real world experience from a Low-Middle income country.

Multiple sclerosis and related disorders
2025

Clinical presentation, MR imaging and outcome in children with myelin oligodendrocyte glycoprotein antibody-negative acute disseminated encephalomyelitis.

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
2025

Acute disseminated encephalomyelitis - a monophonic illness.

International review of neurobiology
2025

Safety of nOPV2 administered during a supplementary immunisation activity in Uganda, 2022: data triangulation from a prospective cohort event monitoring programme and vaccine safety surveillance reports.

The Lancet. Global health
2025

Impact of Anti-MOG Antibody in Diagnosis of Autoimmune Diseases of the Central Nervous System in Children: A Case Series.

Neuropediatrics
2025

Clinical characteristics and factors associated with recurrence and long-term prognosis in patients with MOGAD.

Frontiers in immunology
2025

Adult-onset acute disseminated encephalomyelitis mimicking complex migraine: A CARE-compliant case report.

Medicine
2025

Coronavirus Disease 2019 Infection and Vaccination in Pediatric Demyelinating Diseases.

Pediatric neurology
2025

Acute Disseminated Encephalomyelitis in Children and Adolescents: A Multicenter Retrospective Study of Relapse and Outcome.

Journal of child neurology
2025

Performance of cryptogenic new onset refractory status epilepticus score in a Brazilian cohort after testing for antineuronal antibodies with tissue-based and cell-based assays.

Epilepsia
2025

Fatal Acute Necrotizing Encephalopathy in a 17-Year-Old Girl with COVID-19: A Case Report.

The American journal of case reports
2025

Subacute sclerosing panencephalitis (SSPE) masquerading as acute disseminated encephalomyelitis (ADEM).

BMJ case reports
2025

Modified zipper method in steroid-resistant ADEM: a case report.

Acta neurologica Belgica
2025

Gender and Age Differences in Seronegative Pediatric Acute Disseminated Encephalomyelitis Profiles: Results and Insights from a Tertiary Center.

Iranian journal of child neurology
2025

Clinical Reasoning: A Toddler With Acute-Onset Hypotonia, Areflexia, and Ataxia.

Neurology
2025

Safety monitoring of health outcomes following influenza vaccination during the 2023-2024 season among U.S. Medicare beneficiaries aged 65 years and older.

Vaccine
2025

MOG antibody non-P42 epitope is associated with a higher risk of relapse in paediatric MOGAD.

Journal of neurology, neurosurgery, and psychiatry
2025

Confusing Onset of MOGAD in the Form of Focal Seizures.

Neurology international
2025

Evaluating the Clinical Characteristics and Ophthalmic Manifestations in Children and Adolescents with Acquired Demyelinating Disorders in China.

British journal of hospital medicine (London, England : 2005)
2025

Unravelling the clinical complexity of myelin oligodendrocyte glycoprotein antibody-associated acute disseminated encephalomyelitis in children: a comprehensive analysis.

BMJ case reports
2025

Differentiating Pathology of Acute Disseminated Encephalomyelitis From Multiple Sclerosis in Children Using Diffusion Magnetic Resonance Biomarkers.

Pediatric neurology
2025

Scrub typhus masquerading as other conditions among the pediatric population in India: a case series.

Journal of tropical pediatrics
2025

Longitudinally Extensive Transverse Myelitis (LETM) and Meningoencephalitis Following Acute Epstein-barr Virus Infection in an Immunocompetent Male: Case Report and Review Literature.

Infectious disorders drug targets
2025

Strong association with remote EBV infection in children with MS as opposed to other acquired demyelinating disorders.

Journal of neurology, neurosurgery, and psychiatry
2025

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD): Insights into pathogenesis and biomarkers of prognosis.

Seminars in immunology
2025

Clinical characteristics of children with anti-N-methyl-D-aspartate receptor encephalitis with and without anti-myelin oligodendrocyte glycoprotein antibody.

European journal of pediatrics
2025

Case Report: Long-term suppression of relapses by dimethyl fumarate in a relapsing pediatric patient with myelin oligodendrocyte glycoprotein antibody-associated disease manifesting as acute disseminated encephalomyelitis, unilateral optic neuritis, and seizure episodes.

Frontiers in immunology
2025

A Brainstem-Dominant Acute Disseminated Encephalomyelitis Presenting With Magnetic Resonance Imaging Findings Similar to Those of Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive to Steroid Syndrome.

Clinical case reports
2024

Investigation of the association between circulating inflammatory proteins and encephalitis risk in Europeans by two-sample Mendelian randomization analysis.

Frontiers in neurology
2025

Neuroinflammatory disorders of the central nervous system associated with monkeypox virus: a systematic review and call to action.

BMC medicine
2025

Reviewing the Uncommon Extrahepatic Central Nervous System (CNS) Manifestations of Hepatitis C Virus (HCV) Infection: A Case Report.

Cureus
2025

Advances in Diagnosis and Management of Atypical Demyelinating Diseases.

The Medical clinics of North America
2025

Pseudotumoural optic neuritis in myelin oligodendrocyte glycoprotein antibody-associated disease in children: Pseudotumoural optic neuritis in MOG antibody-associated disease.

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
2024

Pediatric Acute Disseminated Encephalomyelitis Triggered by Concurrent Administration of Seasonal and H1N1 Influenza Vaccines: A Case Report and Review.

NeuroSci
2024

Ofatumumab successfully treats myelin oligodendrocyte glycoprotein antibody-associated disease accompanied by Epstein-Barr viral infection: a case series.

Frontiers in immunology
2024

Hyperintense lesions of the middle cerebellar peduncle and beyond: a pictorial essay.

Radiologia brasileira
2025

MOG antibody-associated disease epidemiology in Olmsted County, USA, and Martinique.

Journal of neurology
2025

Phenotype of Relapsing Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease in Children.

Journal of clinical neurology (Seoul, Korea)
2024

Clinical and immunological features in patients with neuroimmune complications of COVID-19 during Omicron wave in China: a case series.

Frontiers in immunology
2025

Distinguishing Transient From Persistent Brain Structural Changes in Pediatric Patients With Acute Disseminated Encephalomyelitis.

Neurology(R) neuroimmunology &amp; neuroinflammation
2024

[COVID-19 vaccine safety: results of active surveillance at a sentinel site in ArgentinaSegurança das vacinas contra COVID-19: resultados da vigilância ativa em uma unidade sentinela da Argentina].

Revista panamericana de salud publica = Pan American journal of public health
2024

A unique case report revealing the elusive clinical phenomenon of meningitis retention syndrome.

Urology case reports
2024

Management and outcomes of pediatric optic neuritis in a tertiary hospital in Riyadh, Saudi Arabia: a retrospective study.

BMC neurology
2025

Myelin oligodendrocyte glycoprotein antibodyassociated disease (MOGAD): a pediatric case report.

Archivos argentinos de pediatria
2024

Recurrent Acute Disseminated Encephalomyelitis (RADEM) Presenting Beyond "Sixteen-and-a-Half Syndromes".

Annals of Indian Academy of Neurology
2025

Sniffed levamisole-adulterated cocaine mimicking acute demyelinating encephalomyelitis.

Practical neurology
2024

ANTI -NMDA RECEPTOR ENCEPHALITIS: A POSSIBLE APPROACH TO DEVELOP A COST-EFFECTIVE TEST FOR ANTI NMDA RECEPTOR ANTIBODY DETECTION.

Journal of Ayub Medical College, Abbottabad : JAMC
2024

[Report of 3 cases of acute hemorrhagic leukoencephalitis in Mexico].

Revista medica del Instituto Mexicano del Seguro Social
2024

Adult Onset Acute Disseminated Encephalomyelitis: A Case Report.

Cureus
2024

Clinical characteristics of pediatric and adult myelin oligodendrocyte antibody-associated disease (MOGAD): A single-center study in the Northeast.

Multiple sclerosis and related disorders
2023

Characteristics and predictors of disease course in children initially presenting with ADEM.

Multiple sclerosis and related disorders
2024

Multiphasic Acute Disseminated Encephalomyelitis with a Temporal Gap of 26 Years: A Case Report with Novel Presentation.

Case reports in neurology
2024

Overview of emerging therapies for demyelinating diseases.

World journal of clinical cases
2024

Causal relationship between circulating inflammatory proteins and risk of different types of encephalitis: A two-sample Mendelian randomization study.

Cytokine
2024

Dengue-Associated Acute Necrotizing Encephalopathy Is an Acute Necrotizing Encephalopathy Variant Rather than a Mimic: Evidence From a Systematic Review.

Pediatric neurology
2024

Acute disseminated encephalomyelitis (ADEM) in a patient with post streptococcal glomerulonephritis (PSGN): A case report.

Clinical case reports
2024

[From influenza to white matter].

Orvosi hetilap
2025

A Case of Catatonia in a 37-Month-Old Child With Myelin Oligodendrocyte Glycoprotein-Antibody-Positive Acute Disseminated Encephalomyelitis.

Journal of the American Academy of Child and Adolescent Psychiatry
2025

Cognitive and academic outcomes in children with myelin oligodendrocyte glycoprotein antibody-associated disease.

Developmental medicine and child neurology
2024

Pediatric MOG-Ab-Associated Encephalitis: Supporting Early Recognition and Treatment.

Neurology(R) neuroimmunology &amp; neuroinflammation
2024

Cognitive Impairment, Associated Clinical Factors, and MR Volumetric Measures in Myelin Oligodendrocyte Glycoprotein-IgG-Associated Disease.

Neurology(R) neuroimmunology &amp; neuroinflammation
2024

Deciphering Proteomic Expression in Inflammatory Disorders: A Mass Spectrometry Exploration Comparing Infectious, Noninfectious, and Traumatic Brain Injuries in Human Cerebrospinal Fluid.

Neurotrauma reports
2024

Aggressive Course of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD): An Illustration of Two Cases and Review of Literature.

Cureus
2024

Recurrent simultaneous central nervous system demyelination with possible peripheral demyelination / nodopathy in a seronegative patient.

Ideggyogyaszati szemle
2024

Acute Disseminated Encephalomyelitis Presenting with Neuropsychiatric Symptoms.

Case reports in pediatrics
2024

Cerebral Cortical Encephalitis and Other Meningocortical Manifestations of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease in Children: Case Series and Review of the Literature.

Journal of child neurology
2024

Acute Hemorrhagic Leukoencephalitis in a Patient With Hepatitis B.

Cureus
2025

Changes in the Incidence of Optic Neuritis before and after the Coronavirus Disease 2019 Outbreak: A Nationwide Study 2017-2022.

Ophthalmology
2024

NMOSD and MOGAD: an evolving disease spectrum.

Nature reviews. Neurology
2024

Case report: The histopathological analyses of two myelin oligodendrocyte glycoprotein antibody-associated diseases with a distinctive linear radiating gadolinium enhancement on MRI.

Frontiers in immunology
2025

Radiological features in pediatric myelin oligodendrocyte glycoprotein antibody-associated disease-diagnostic criteria and lesion dynamics.

Pediatric radiology
2024

Acute hemorrhagic leukoencephalopathy: a case report and literature review.

Annals of medicine and surgery (2012)
2024

Thunderclap headache as a first manifestation of acute disseminated encephalomyelitis: case report and literature review.

BMC neurology
2025

Acute disseminated encephalomyelitis following herpesvirus encephalitis in an adult: a case report.

Acta neurologica Belgica
2024

[The central vein sign in the differential diagnosis of multiple sclerosis].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
2024

[Modern pathogenetic treatment of rare demyelinating diseases].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
2024

Bilateral Cerebellar Hemorrhages: An Atypical Presentation of Acute Hemorrhagic Encephalomyelitis.

Cureus
2024

Study of seasonality of attacks in MOG antibody-associated disease.

Multiple sclerosis and related disorders
2024

Evaluating Therapeutic Plasma Exchange in Pediatric Acute Disseminated Encephalomyelitis: A Comprehensive Review.

Cureus
2024

Examining cognition and brain networks using magnetoencephalography in paediatric autoimmune encephalitis and acute disseminated encephalomyelitis: a preliminary study.

Brain communications
2024

Homonymous hemianopia following yellow fever vaccination: a case of acute disseminated encephalomyelitis.

Journal of travel medicine
2024

Isolated Intracranial Hypertensions as Onset of Myelin Oligodendrocyte Glycoprotein Antibody Disease.

Journal of clinical medicine
2024

Recovery from acute haemorrhagic leucoencephalitis secondary to COVID-19.

BMJ case reports
2024

Acute hemorrhagic leukoencephalitis: a case report and systematic review of factors associated with severe disability and death.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2024

Clinical pattern, neuroimaging findings and outcome of Acute Disseminated Encephalomyelitis in children: A retrospective study.

Pakistan journal of medical sciences
2024

Successful treatment of a complete Susac syndrome in a 16-year-old boy: A case report.

Clinical case reports
2024

Parkinsonism Associated with Snakebite.

Annals of African medicine
2024

Bilateral optic neuritis and encephalopathy as the atypical presentations of multiple sclerosis following severe acute respiratory syndrome coronavirus 2 infection.

Taiwan journal of ophthalmology
2025

An Insight into Disseminated Acute Encephalomyelitis Pathogenesis and Treatment-A Review.

Current aging science
2024

Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD) Initially Presenting as Septic Meningoencephalitis in a 16-Year-Old Male.

European journal of case reports in internal medicine
2023

Bilateral Optic Neuritis in a Child with Acute Disseminated Encephalomyelitis: A Case Report.

Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH
2024

Acute disseminated encephalomyelitis in a young patient: A case report.

Experimental and therapeutic medicine
2024

Frequency of Asymptomatic Optic Nerve Enhancement in 203 Patients With MOG Antibody-Associated Disease.

Neurology(R) neuroimmunology &amp; neuroinflammation
2024

Dengue Fever Accompanied by Neurological Manifestations: Challenges and Treatment.

Cureus
2025

Acute Hemorrhagic Leukoencephalitis with Concurrent Retinal Vasculitis in an Elderly Japanese Patient.

Internal medicine (Tokyo, Japan)
2024

A meta-analysis of Chikungunya virus in neurological disorders.

Infectious diseases now
2024

A burning encephalitis: Fluid-attenuated inversion recovery-hyperintense lesions in Anti-myelin oligodendrocyte glycoprotein-associated encephalitis with seizures in anti-myelin oligodendrocyte glycoprotein-associated encephalitis with seizures-A case report and review of the literature.

SAGE open medical case reports
2024

Postdengue Acute Disseminated Encephalomyelitis.

The Journal of the Association of Physicians of India
2024

Long-term outcomes of ADEM-like and tumefactive presentations of CNS demyelination: a case-comparison analysis.

Journal of neurology
2024

Unravelling the Complexity of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.

Cureus
2024

Clinical, Demographic, and Radiological Characteristics of Patients Demonstrating Antibodies Against Myelin Oligodendrocyte Glycoprotein.

Balkan medical journal
2024

An Unusual Case of Cryoglobulinemic Vasculitis and Acute Disseminating Encephalomyelitis in a 21-Year-Old Caucasian Male.

Cureus
2024

Central nervous system manifestations following vaccination against COVID-19.

Brain, behavior, &amp; immunity - health
2024

Mimics of Guillain-Barré Syndrome in Pediatric Patients Admitted to the Neuro-Intensive Care Unit of a Tertiary Care Hospital-A Case Series.

Neurology India
2024

MOG Antibody Disease: Nuances in Presentation, Diagnosis, and Management.

Current neurology and neuroscience reports
2024

Myelin Oligodendrocyte Glycoprotein-Antibody Associated Disease: An Updated Review of the Clinical Spectrum, Pathogenetic Mechanisms and Therapeutic Management.

Antibodies (Basel, Switzerland)
2024

Novel Genetic Variants Distinguishing Myelin Oligodendrocyte Glycoprotein-IgG-Positive From Myelin Oligodendrocyte Glycoprotein-IgG-Negative Pediatric Acute Disseminated Encephalomyelitis in Northern China.

Pediatric neurology
2024

Catastrophic tumefactive acute disseminated encephalomyelitis in patient with dengue virus: a case report.

Journal of neurovirology
Ver todos os 1.168 no EuropePMC

Associações

Organizações que acompanham esta doença — pra ter apoio e orientação

Ainda não temos associações cadastradas para Encefalite disseminada aguda.

É de uma associação que acompanha esta doença? Fale com a gente →

Comunidades

Grupos ativos de quem convive com esta doença aqui no Raras

Ainda não existe comunidade no Raras para Encefalite disseminada aguda

Pacientes, familiares e cuidadores se organizam em comunidades pra compartilhar experiências, fazer perguntas e se apoiar. Você pode ser o primeiro.

Tire suas dúvidas

Perguntas, dicas e experiências compartilhadas aqui na página

Participe da discussão

Faça login para postar dúvidas, compartilhar experiências e interagir com especialistas.

Fazer login

Doenças relacionadas

Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico

Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Postmarketing safety surveillance for GSK's AS01E-adjuvanted respiratory syncytial virus prefusion F protein-based vaccine in the USA: protocol for a non-interventional postauthorisation safety study.
    BMJ open· 2026· PMID 41856590mais citado
  2. Acute Disseminated Encephalomyelitis (ADEM): Current View into Etiopathogenesis and Clinical Features.
    Brain sciences· 2026· PMID 41750202mais citado
  3. Natural experiment on neuroinflammatory disease incidence and infection links pre- and post-COVID-19.
    Brain : a journal of neurology· 2026· PMID 41359492mais citado
  4. Biomarkers to predict relapse in myelin oligodendrocyte glycoprotein antibody-associated disease: a systematic review and meta-analysis.
    Journal of neurology, neurosurgery, and psychiatry· 2026· PMID 41033784mais citado
  5. Post malaria neurological syndrome and acute disseminated encephalomyelitis: a case highlighting an ongoing debate.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology· 2026· PMID 41622363mais citado
  6. 후뇌염의 영상 소견 스펙트럼: 임상 화보.
    J Korean Soc Radiol· 2026· PMID 41971108recente
  7. Analysis of risk factors for relapse in pediatric MOG antibody-associated disease: a single-center retrospective cohort study.
    Front Neurol· 2026· PMID 41970046recente
  8. Neurological fallout of hyperglycemia: A case report of a rare presentation of osmotic demyelination syndrome.
    Qatar Med J· 2026· PMID 41953404recente
  9. The invisible emergencies: metabolic and neuro-critical disorders often missed in the pediatric ED - a narrative review.
    Int J Emerg Med· 2026· PMID 41917810recente
  10. Subtle Infantile Hemiparesis as a Presentation of Acute Disseminated Encephalomyelitis: The Value of Caregiver Video Documentation.
    Clin Case Rep· 2025· PMID 41909723recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:83597(Orphanet)
  2. MONDO:0019383(MONDO)
  3. GARD:8639(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Artigo Wikipedia(Wikipedia)
  6. Q424242(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Encefalite disseminada aguda
Compêndio · Raras BR

Encefalite disseminada aguda

ORPHA:83597 · MONDO:0019383
Prevalência
Unknown
Herança
Not applicable
CID-10
G04.0 · Encefalite aguda disseminada
CID-11
Ensaios
11 ativos
Início
All ages
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C0014059
Repurposing
1 candidato
tolperisonevoltage-gated sodium channel blocker
EuropePMC
Wikidata
Wikipedia
Papers 10a
DiscussaoAtiva

Nenhuma novidade ainda. O agente esta monitorando.

0membros
0novidades