Produção baixa dos hormônios da camada externa das glândulas suprarrenais (também chamadas de adrenais). Isso ocorre porque o próprio sistema de defesa do corpo ataca e destrói essas glândulas.
Introdução
O que você precisa saber de cara
Produção baixa dos hormônios da camada externa das glândulas suprarrenais (também chamadas de adrenais). Isso ocorre porque o próprio sistema de defesa do corpo ataca e destrói essas glândulas.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Entender a doença
Do básico ao detalhe, leia no seu ritmo
Preparando trilha educativa...
Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 27 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 56 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Genética e causas
O que está alterado no DNA e como passa nas famílias
Nenhum gene associado encontrado
Os dados genéticos desta condição ainda estão sendo catalogados.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Doença de Addison
Selecione um estado ou use sua localização para ver resultados.
Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
🟢 Recrutando agora
1 pesquisa recrutando participantes. Converse com seu médico sobre a possibilidade de participar.
Outros ensaios clínicos
41 ensaios clínicos encontrados, 3 ativos.
Publicações mais relevantes
GDF15 in Patients with Autoimmune Primary Adrenal Insufficiency.
Growth differentiation factor 15 (GDF15) is a stress-response protein that conveys cellular distress signals to the brain and activates neural pathways leading to weight loss. GDF15 levels are increased in glucocorticoid deficiency; however, multiple factors may influence its levels in patients with primary adrenal insufficiency (PAI). The objective of this study was to determine circulating GDF15 levels in patients with PAI compared with a control group and to assess their associations with other clinical parameters. We included 37 patients (22 females) with autoimmune PAI and 47 healthy controls. Serum GDF15 levels, together with anthropometrical, hormonal and biochemical parameters, were assessed. Patients with PAI had significantly higher circulating GDF15 levels than controls did (1276.8 ± 952.1 vs. 682.8 ± 270.2 pg/mL, p < 0.001). In both groups, GDF15 levels were positively correlated with age (p < 0.001). In patients with PAI, GDF15 showed positive correlations with disease duration and duration of autoimmune thyroid disease, gonadotropin levels, waist-to-hip ratio, and body fat percentage, and negative correlations with DHEAS and sex hormone levels. In conclusion, GDF15 levels are increased in patients with PAI compared with healthy controls and correlate with age and the duration of autoimmune disease. The cosyntropin stimulation test is a dynamic endocrine test used to evaluate adrenal cortical function and assess the integrity of the hypothalamic–pituitary–adrenal (HPA) axis. Cosyntropin is a synthetic analog of adrenocorticotropic hormone (ACTH) that stimulates the adrenal cortex to produce cortisol. By measuring serum cortisol levels before and after cosyntropin administration, clinicians can determine whether the adrenal glands respond appropriately to ACTH stimulation. This test is most commonly used to evaluate suspected adrenal insufficiency, including primary adrenal insufficiency (Addison disease) and certain cases of secondary or tertiary adrenal insufficiency. The test is critical in differentiating causes of cortisol deficiency, supporting timely diagnosis, and guiding appropriate glucocorticoid replacement therapy to prevent adrenal crisis.
Clinical features, investigation, and management of Addison's disease.
Addison's disease is the manifestation of adrenal glucocorticoid and mineralocorticoid deficiency from T-cell mediated destruction of the adrenal cortex, and is the commonest cause of primary adrenal insufficiency in adults. Due to its vague presentation, diagnosis of Addison's disease is often delayed, and in some cases, individuals present in adrenal crisis. Despite the use of corticosteroid replacement therapy, people with Addison's disease have increased mortality and reduced quality of life. Multiple features are thought to contribute to these outcomes, including inadequacy of adrenal crisis management and the inability of existing therapies to mimic circadian and ultradian rhythms of cortisol release. Current research strategies focus on understanding social and behavioural factors that contribute to adrenal crises, developing therapies that more closely mimic rhythms of physiological cortisol secretion, and developing interventions to restore adrenal steroidogenesis. This Review discusses the clinical features, investigation, and management of Addison's disease.
Addison-like Clinical Phenotype Without Adrenal Insufficiency: A Rare Manifestation of Pernicious Anemia.
Severe vitamin B12 deficiency can clinically mimic Addison disease, with hyperpigmentation despite preserved adrenal function. We report a 34-year-old woman presenting with fatigue, an unintended weight loss of about 20 kg, and mucocutaneous hyperpigmentation raising concern for primary adrenal insufficiency. Examination showed pallor, mild scleral icterus, and elevated blood pressure. Laboratory testing demonstrated severe cobalamin deficiency with macrocytic anemia and biochemical evidence of intramedullary hemolysis, whereas morning cortisol and ACTH levels excluded adrenal failure. Intrinsic factor antibodies confirmed pernicious anemia. Notably, cancer antigen 15-3 was elevated at presentation but normalized after intramuscular vitamin B12 replacement, indicating a benign hematologic rather than oncologic etiology. Treatment triggered an appropriate reticulocyte response with subsequent hematologic recovery and gradual resolution of the hyperpigmentation. Pernicious anemia should be considered in the differential diagnosis of Addison-like pigmentation without adrenal insufficiency. Recognizing that tumor marker elevation may occur in severe megaloblastic anemia is essential to prevent unnecessary oncologic workup.
Allgrove syndrome with early neurodegeneration in a child: A case report from Syria.
Allgrove syndrome (AS), or "Triple A" syndrome, is a rare autosomal recessive disorder first described in 1978. It affects approximately 1 in a million individuals and is caused by mutations in the AAAS gene on chromosome 12q13. This gene encodes the ALADIN protein, essential for cellular function in various tissues. The syndrome is defined by a triad of clinical features: alacrima (absence of tears), achalasia (esophageal dysfunction), and adrenocorticotropic hormone-resistant adrenal insufficiency. Neurological involvement, including autonomic and peripheral neuropathies, is more commonly observed later in life, making early diagnosis challenging. A 4-year-old girl presented with vomiting, dysphagia, generalized weakness, alacrima, and skin hyperpigmentation. Addison disease was confirmed by elevated adrenocorticotropic hormone levels, and achalasia was diagnosed via a barium swallow test showing a bird's beak sign. Although treatment was initiated, surgery was initially delayed due to the patient's condition. Later, she developed seizures and neurological deterioration. Magnetic resonance imaging revealed cerebral atrophy, confirming the diagnosis of AS with neurological involvement. Treatment included medications targeting adrenal insufficiency and symptom management; however, there was no significant improvement in neurological symptoms or oral intake. Surgical intervention with Heller myotomy and gastrostomy led to improved feeding. AS can lead to serious complications, including life-threatening adrenal crises if undiagnosed. Early identification of glucocorticoid deficiency is vital to prevent mortality and long-term morbidity. Timely recognition and a multidisciplinary approach are essential. Regular follow-ups are necessary to manage neurological progression and support normal development in affected children.
Severe Hyperpigmentation in the Emergency Department.
Cortisol, widely recognized as the principal stress hormone, exerts extensive influence over numerous physiological processes throughout the body. This hormone functions as the primary glucocorticoid synthesized and released by the zona fasciculata of the adrenal cortex. The hypothalamic-pituitary-adrenal (HPA) axis governs cortisol production and secretion, and disruption of this regulatory system results in cortisol excess disorders such as Cushing syndrome or deficiency states such as Addison disease (see Image. Hypothalamic-Pituitary-Adrenal Axis). Cortisol influences metabolism, immune activity, cardiovascular tone, and the stress response by modulating glucose availability, protein catabolism, lipolysis, and inflammatory signaling. Excessive cortisol exposure, such as in Cushing syndrome, produces central obesity, muscle wasting, hypertension, and glucose intolerance. Cortisol deficiency, such as in Addison disease, causes fatigue, hypotension, weight loss, and hyperpigmentation. Understanding cortisol physiology enables clinicians to recognize deviations from normal regulation, interpret diagnostic findings accurately, and design targeted therapeutic strategies for endocrine and systemic disorders involving the HPA axis.
Publicações recentes
Between Crisis and Clarity: Steroid-Induced Psychosis in Addison Disease.
Adrenocorticotropic Hormone (Cosyntropin) Stimulation Test.
Addison-like Clinical Phenotype Without Adrenal Insufficiency: A Rare Manifestation of Pernicious Anemia.
Allgrove syndrome with early neurodegeneration in a child: A case report from Syria.
Dizziness and orthostatic hypotension in a college student.
📚 EuropePMC134 artigos no totalmostrando 196
GDF15 in Patients with Autoimmune Primary Adrenal Insufficiency.
International journal of molecular sciencesAddison-like Clinical Phenotype Without Adrenal Insufficiency: A Rare Manifestation of Pernicious Anemia.
JCEM case reportsClinical features, investigation, and management of Addison's disease.
The lancet. Diabetes & endocrinologyAllgrove syndrome with early neurodegeneration in a child: A case report from Syria.
MedicineCo-existence of Myasthenia Gravis and Addison's Disease Without Thymoma: A Case Report.
Neuro endocrinology lettersAdrenal insufficiency presenting with psychosis.
BMJ case reportsDizziness and orthostatic hypotension in a college student.
Journal of American college health : J of ACHSevere Hyperpigmentation in the Emergency Department.
JCEM case reportsPrimary adrenocortical insufficiency in patients with AIDS in Wuhan, China: 3 cases report and literature review.
BMC infectious diseasesInflammation-Mediated Lipid Metabolism in Endocrine Autoimmune Diseases: A Genetic Distance-Based PRS Approach Integrating HLA Region.
GenesUnmasking adrenal insufficiency: the overlooked role of gastrointestinal symptoms.
The American journal of medicine[A case report of delayed-onset diabetes mellitus complicated with primary adrenal insufficiency induced by immune checkpoint inhibitors].
Zhonghua nei ke za zhiA practical approach to diagnosis and treatment in children with primary adrenal insufficiency.
European journal of endocrinologyThe impact of age on the Na:K ratio: observations from a general canine population.
Frontiers in veterinary scienceHypoglycaemia and other risks of ramadan fasting in patients with primary adrenal insufficiency: A prospective controlled trial using 24-hour glucose monitoring.
Journal of endocrinological investigationRare causes of pediatric primary adrenal insufficiency: Data from a large nationwide Tunisian cohort.
Annales d'endocrinologieGlucocorticoid receptor polymorphisms and bone mineral density in patients receiving conventional glucocorticoid replacement.
Endokrynologia PolskaA DESCRIPTION OF ADDISON'S DISEASE, AND ITS NEUROPSYCHIATRIC MANIFESTATIONS COMPARING THE DISEASE AS IT IS NOW TO THE DISEASE AS EXPERIENCED BY SAINT ELIZABETH OF THE TRINITY IN 1906.
Psychiatria DanubinaAn unusual case of remission of clinically overt autoimmune Addison's disease in a Pakistani girl.
Pakistan journal of medical sciencesIncreased mortality in primary adrenal insufficiency: a systematic review and meta-analysis.
European journal of endocrinologyGenetic association and potential mediators between subjective well-being and cardiovascular events: A bidirectional two-sample, two-step Mendelian randomization study.
MedicineThe mask of deficiency: A rare case of facial hyperpigmentation in vitamin B12 deficiency - a case report and review of literature.
Tropical doctorUnmasking Addison's Disease: A Case of Acute Adrenal Crisis.
The Journal of the Association of Physicians of IndiaMineralocorticoid effects of fludrocortisone and hydrocortisone in primary adrenal insufficiency: EU-AIR patient data.
Journal of endocrinological investigation[Two cases of X-linked adrenoleukodystrophy presenting with Addison's disease as the initial manifestation and analysis of novel ABCD1 variants].
Zhonghua nei ke za zhiOnset of Addison Disease in a Patient Using the Advanced Hybrid Closed-Loop MiniMed 780G: Diagnostic Challenges.
JCEM case reportsAddison's disease due to adrenal insufficiency in an immunocompetent patient with disseminated cryptococcosis. Case report.
Revista peruana de medicina experimental y salud publicaThe Relationship Between Sleep, Fatigue and Quality of Life in Young Adults With Autoimmune Addison's Disease.
Clinical endocrinologyAn Intriguing Case Report of Type 2 Autoimmune Polyendocrine Syndrome Post-SARS-CoV-2: Cause or Coincidence?
Endocrine, metabolic & immune disorders drug targets[A rare case of autoimmune polyglandular syndrome type 2 in an elderly patient].
MedicinaIncidental diagnosis of primary adrenal insufficiency precipitated by positive ABCD1 gene mutation detected on cascade screening.
BMJ case reportsPsychotropic drug use in patients with autoimmune Addison's disease: a Swedish population-based cohort study.
European journal of endocrinologyAdrenal crisis: incidence, clinical presentation and risk factors in patients with Addison's disease.
EndocrineSevere cutaneous adverse reactions and risk of autoimmune disease, including psoriasis and inflammatory bowel disease: a cohort study.
Clinical and experimental dermatologyIdentifying Knowledge Gaps in Individuals With Primary Adrenal Insufficiency: A Critical Step in Preventing Adrenal Crisis.
Clinical endocrinologyFemale fertility and pregnancy in autoimmune Addison's disease - a mini review.
Frontiers in endocrinologyTwo Hurt More Than One: Severe Hyponatraemia and Rhabdomyolysis as Presenting Features of Addison's Disease.
Acta medica (Hradec Kralove)Prevalence of Various Systemic and Organ-Specific Autoimmune Markers in Addison's Disease Patients Compared to Healthy Controls.
Journal of clinical medicinePrimary adrenal insufficiency and systemic tuberculosis in a 10-year-old boy: case report.
Revista peruana de medicina experimental y salud publica[Hypoglycaemic ketoacidosis - an endocrine emergency].
Deutsche medizinische Wochenschrift (1946)[Adrenal Insufficiency: Etiology and Characterization of Patients Attended at a University Center].
Revista medica de ChileEating Disorder vs Addison's Disease: A Case Report and Review of the Published Case Reports.
Actas espanolas de psiquiatria[Xp21 contiguous gene deletion syndrome].
Zhurnal nevrologii i psikhiatrii imeni S.S. KorsakovaPrimary adrenal insufficiency caused by pseudo-neonatal adrenoleukodystrophy associated with biallelic ACOX1 mutations.
European journal of endocrinologyPrimary adrenal insufficiency in patients with CPOX gene mutations.
European journal of endocrinologyAutoimmune Primary Adrenal Insufficiency: Understanding the Past, Present, and Future.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical EndocrinologistsCase Report: Primary adrenal insufficiency due to bilateral adrenal infarction and antiphospholipid syndrome in Covid19 - A complicate case of cardiogenic shock.
Frontiers in endocrinologyIncreased risk of osteoporotic fractures and osteoporosis in patients with Addison's disease in Sweden: A nationwide population-based cohort study.
Journal of internal medicinePregnancy Outcomes in Women With Primary Adrenal Insufficiency: Data From a Multicentre Cohort Study.
BJOG : an international journal of obstetrics and gynaecologyChanges in Adrenal Function and Insufficiency Symptoms After Cessation of Prednisolone.
JAMA network openProgressive Disseminated Histoplasmosis with Primary Adrenal Insufficiency in Immunocompetent Person: A Case Report.
The Journal of the Association of Physicians of IndiaPregnancy-Induced Hypertension and Association With Future Autoimmune Diseases.
Obstetrics and gynecologyIncome and work loss in patients with Addison's disease: a nationwide population-based study.
European journal of endocrinologyAnti-perilipin-1 autoantibodies in autoimmune Addison's disease and related endocrine disorders.
AutoimmunitySubject-Specific Dosage Estimation for Primary Hypothyroidism Using Sparse Data.
Journal of computational biology : a journal of computational molecular cell biologyChallenges of diagnosing and managing Addison's disease in a resource-limited setting.
BMJ case reportsAdrenal Insufficiency Due to Adrenal Insult Following Acute Pancreatitis in a Child.
JCEM case reportsDual-release hydrocortisone treatment improves serum and peripheral blood mononuclear cell inflammatory and immune profiles in patients with autoimmune primary adrenal insufficiency.
Frontiers in immunologyInsights in non-CAH pediatric primary adrenal insufficiency: a single-center experience from India.
Journal of pediatric endocrinology & metabolism : JPEMGenetics of Primary Adrenal Insufficiency Beyond CAH in Saudi Arabian Population.
Molecular genetics & genomic medicine[Addison's disease: looking to the past and the future].
Revue medicale de LiegeThe Causes and Diagnosis of Non-congenital Adrenal Hyperplasia Primary Adrenal Insufficiency in Children.
Journal of clinical research in pediatric endocrinologyPrimary adrenal insufficiency: case study IN 5 tertiary hospitals.
Anales de pediatriaTrio-based exome sequencing and high-resolution HLA typing in families of patients with autoimmune adrenal insufficiency and autoimmune polyglandular syndrome.
PloS oneCirculatory collapse requiring mechanical circulatory support in a child with autoimmune adrenal insufficiency: a case report.
BMC pediatricsA Rare Presentation of a Common Disease: A Case Report.
The Journal of the Association of Physicians of IndiaThe multiple faces of autoimmune Addison's disease in children.
Frontiers in endocrinologyBrain activity during working memory in patients with autoimmune Addison's disease.
PsychoneuroendocrinologyHypoadrenocorticism in cats: a 40-year update.
Journal of feline medicine and surgerySchmidt´s syndrome found by tan: a case report.
The Pan African medical journalPrimary adrenal insufficiency with normal male external genitalia in a boy with CYP11A1 deficiency.
BMJ case reportsIncreased prevalence of negative pregnancy and fetal outcomes in women with primary adrenal insufficiency. A systematic review and meta-analysis.
EndocrinePrimary adrenal insufficiency in adults: When to suspect, how to diagnose and manage.
Cleveland Clinic journal of medicinePrimary hyperaldosteronism associated with type 3 autoimmune polyendocrine syndrome: A rare case report.
Clinical case reportsDiagnostic Role of Tomography in Addison's Disease due to Adrenal Tuberculosis: A Case Report.
Endocrine, metabolic & immune disorders drug targetsStokes-Adams Syndrome as a Presenting Feature of Hypoadrenalism: A Rare Presentation.
Annals of African medicineDermatological Conundrum: Puzzling Pigmentation in Vitamin B12 Deficiency and Addison's Disease.
The Journal of the Association of Physicians of IndiaEasily misdiagnosed X-linked adrenoleukodystrophy.
Italian journal of pediatricsImmune Checkpoint Inhibitors-Induced Endocrinopathies: Assessment, Management and Monitoring in a Comprehensive Cancer Centre.
Endocrinology, diabetes & metabolismSecondary adrenocortical insufficiency after treatment with retifanlimab: a case report.
Frontiers in immunologyCardiac tamponade - a rare cause of sudden death in autoimmune polyglandular syndrome.
Forensic science, medicine, and pathologyPrimary adrenal insufficiency due to lymphomatoid granulomatosis in a 32-year-old man.
Lancet (London, England)Autoimmune polyglandular syndrome with shock and high anion gap metabolic acidosis.
The American journal of the medical sciencesAdherence to glucocorticoid replacement therapy in Addison's disease: Association with patients' disease knowledge and quality of life.
Endocrinologia, diabetes y nutricionDisseminated tuberculosis in PLWHIV presenting as primary adrenal insufficiency.
BMJ case reportsPrimary adrenal insufficiency developed 22 years after the diagnosis of light and heavy chain deposition disease: a case report.
CEN case reportsAddison's disease in metastatic neuroendocrine prostate cancer.
Endocrinologia, diabetes y nutricionToxic Epidermal Necrolysis Secondary to Iodine Versus Methimazole in a Pediatric Patient With Complex Autoimmune Disease.
CureusExcessive pickle consumption: beware of adrenal crisis.
Archives de pediatrie : organe officiel de la Societe francaise de pediatrieMonitoring adrenal insufficiency through salivary steroids: a pilot study.
European journal of endocrinology[Diagnosis and etiology of primary adrenal insufficiency].
Revue medicale suisseRare copy number variation in autoimmune Addison's disease.
Frontiers in immunologyAssessment of bidirectional relationships between autoimmune diseases and primary ovarian insufficiency: insights from a bidirectional two-sample Mendelian randomization analysis.
Archives of gynecology and obstetricsAdrenal Hemorrhage: A Comprehensive Analysis of a Heterogeneous Entity-Etiology, Presentation, Management, and Outcomes.
Mayo Clinic proceedingsChallenges and pitfalls in the management of endocrine toxicities from immune checkpoint inhibitors: a case presentation of synchronous thyrotoxicosis and primary adrenal insufficiency in a melanoma patient.
Hormones (Athens, Greece)Follow up of a rare case of adrenal insufficiency due to NNT mutation.
BMJ case reportsHyperpigmentation at diabetes technology sites may be indicative of evolving Addison's disease.
Archives of disease in childhoodPredictors of bone mineral density in patients receiving glucocorticoid replacement for Addison's disease.
EndocrineLack of NAD(P)+ transhydrogenase activity in patients with primary adrenal insufficiency due to NNT variants.
European journal of endocrinologyClinical presentation and outcomes in patients with antiphospholipid syndrome-associated adrenal hemorrhage. A multicenter cohort study and systematic literature review.
Clinical immunology (Orlando, Fla.)Posaconazole-induced primary adrenal insufficiency: A rare but real risk.
Annales d'endocrinologie[Case Report of a 14-Year-Old Girl with Addison's Disease Under Initial Presumptive Diagnosis of Anorexia Nervosa: Confusingly Similar and Yet so Different?].
Zeitschrift fur Kinder- und Jugendpsychiatrie und PsychotherapieFamilial Glucocorticoid Deficiency: the changing landscape of an eponymous syndrome.
Frontiers in endocrinologyPrimary adrenal insufficiency induced by immune checkpoint inhibitors: biological, clinical, and radiological aspects.
Seminars in oncologyPrimary Adrenal Insufficiency due to Cryptococcus With Persistent Adrenal Enlargement and Insufficiency.
AACE clinical case reportsMajor immunophenotypic abnormalities in patients with primary adrenal insufficiency of different etiology.
Frontiers in immunologyX-linked adrenoleukodystrophy and primary adrenal insufficiency.
Frontiers in endocrinologyAutoimmune primary adrenal insufficiency -current diagnostic approaches and future perspectives.
Frontiers in endocrinologyPredisposing factors for adrenal crisis in chronic adrenal insufficiency: a case-control study.
European journal of endocrinologyOn Primary Adrenal Insufficiency with Normal Concentrations of Cortisol - Early Manifestation of Addison's Disease.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolismeRole of the NLRP1 inflammasome in skin cancer and inflammatory skin diseases.
The British journal of dermatologyA case-control survey study of environmental risk factors for primary hypoadrenocorticism in dogs.
Journal of veterinary internal medicineMorbidity in Patients with Chronic Adrenal Insufficiency - Cardiovascular Risk Factors and Hospitalization Rate Compared to Population Based Controls.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolismeIncreased Resting-State Functional Connectivity in Patients With Autoimmune Addison Disease.
The Journal of clinical endocrinology and metabolismAltered biomarkers for cardiovascular disease and inflammation in autoimmune Addison's disease - a cross-sectional study.
European journal of endocrinologyBone safety of dual-release hydrocortisone in patients with autoimmune primary adrenal insufficiency.
Frontiers in endocrinologyAutoimmune Disease in Turner Syndrome in Sweden: An up to 25 Years' Controlled Follow-up Study.
The Journal of clinical endocrinology and metabolismA Patient with Addison Disease (Primary Adrenal Insufficiency) Presenting for Surgical Extraction of Third Molars.
Dental clinics of North AmericaA First Presentation of Autoimmune Primary Adrenal Insufficiency.
The American journal of medicineAutoimmune Addison's disease in the preclinical period mimics malignancy on 18F-FDG PET/CT.
Annales d'endocrinologieSimultaneous diagnosis of primary adrenal insufficiency and Type 1 diabetes mellitus.
Journal of paediatrics and child healthMelanonychia with pseudo-Hutchinson sign may assist in diagnosis of Addison's disease.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)Serological Screening for Celiac Disease and Gastrointestinal Absorption Disorders in Patients with Autoimmune Endocrine Diseases.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolismeGenetic and phenotypic spectrum of non-21-hydroxylase-deficiency primary adrenal insufficiency in childhood: data from 111 Chinese patients.
Journal of medical geneticsRegulatory T cells in autoimmune primary adrenal insufficiency.
Clinical and experimental immunologyPrimary Adrenal Insufficiency Masked by an Eating Disorder Diagnosis in an Adolescent Male.
JCEM case reportsA "Grasp Heart" Situation: Managing Heart Failure with Reduced Ejection Fraction in Primary Adrenal Insufficiency.
Arquivos brasileiros de cardiologiaRelation between HLA and copy number variation of steroid 21-hydroxylase in a Swedish cohort of patients with autoimmune Addison's disease.
European journal of endocrinologyAutoimmune adrenal insufficiency in children: a hint for polyglandular syndrome type 2?
Italian journal of pediatricsApproach to the Patient: Diagnosis of Primary Adrenal Insufficiency in Adults.
The Journal of clinical endocrinology and metabolismPrimary adrenal insufficiency due to bilateral adrenal hemorrhage-adrenal infarction in a patient with systemic lupus erythematosus and antiphospholipid syndrome: case presentation and review of the literature.
Hormones (Athens, Greece)Association of vitiligo with multiple cutaneous and extra-cutaneous autoimmune diseases: a nationwide cross-sectional study.
Archives of dermatological researchA novel mutation in the NNT gene causing familial glucocorticoid deficiency, with a literature review.
Annales d'endocrinologieAddison's Disease: Diagnosis and Management Strategies.
International journal of general medicineAn unusual cause of adrenal insufficiency with elevation of 17-hydroxyprogesterone: case report.
BMC endocrine disordersTesticular adrenal rest tumors in Addison's disease.
Endocrinologia, diabetes y nutricionEpidemiology and Causes of Primary Adrenal Insufficiency in Children: A Population-Based Study.
The Journal of clinical endocrinology and metabolismAcute Mania in a Patient With Primary Adrenal Insufficiency Due to Autoimmune Adrenalitis: A Case Report.
Journal of psychiatric practicePulsatile Subcutaneous Hydrocortisone Replacement in Primary Adrenal Insufficiency.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolismeA polygenic risk score to help discriminate primary adrenal insufficiency of different etiologies.
Journal of internal medicineAdrenal insufficiency after curative-intent gastric cancer treatment: a case report.
Journal of medical case reportsAcute Mania and Psychosis in the Context of Primary Adrenal Insufficiency: A Systematic Review of the Literature.
Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive NeurologyTwo Single Nucleotide Deletions in the ABCD1 Gene Causing Distinct Phenotypes of X-Linked Adrenoleukodystrophy.
International journal of molecular sciencesSteroid supplementation before minor oral surgical procedures in patients taking long-term glucocorticoids: A triple-blinded, randomized, placebo-controlled trial.
Journal of the American Dental Association (1939)Diagnosis and management of adrenal insufficiency.
Clinical medicine (London, England)Complete heart block revealing adrenal tuberculosis.
Radiology case reportsAn 11-year-old girl with Autoimmune Polyglandular Syndrome (APS) type 2: a case report and review of literature.
Journal of pediatric endocrinology & metabolism : JPEMSex-disease dimorphism underpins enhanced motion sickness susceptibility in primary adrenal insufficiency: a cross-sectional observational study.
Experimental brain researchAcute Diarrhea Isn't Always Infectious: An Atypical Presentation of Adrenal Insufficiency.
Journal of community hospital internal medicine perspectivesClinical features and long-term management of cats with primary hypoadrenocorticism using desoxycorticosterone pivalate and prednisolone.
Journal of veterinary internal medicineEffects of the therapy shift from cortisone acetate to modified-release hydrocortisone in a group of patients with adrenal insufficiency.
Frontiers in endocrinologySelf-management and hospitalization in 615 Swedish patients with Addison's disease during the coronavirus disease 2019 pandemic: a retrospective study.
European journal of endocrinologyCoronary artery disease in a patient with Addison's disease: a case report and literature review.
BMC cardiovascular disordersAddison's Disease in the Course of Recurrent Microangiopathic Antiphospholipid Syndrome-A Clinical Presentation and Review of the Literature.
Medicina (Kaunas, Lithuania)Replication of association at the LPP and UBASH3A loci in a UK autoimmune Addison's disease cohort.
European journal of endocrinologyAdrenal Insufficiency in Peroxisomal Disorders: A Single Institution Case Series.
Hormone research in paediatricsFuture Directions for Adrenal Insufficiency: Cellular Transplantation and Genetic Therapies.
The Journal of clinical endocrinology and metabolismType 3 autoimmune polyglandular syndrome (APS-3) or type 3 multiple autoimmune syndrome (MAS-3): an expanding galaxy.
Journal of endocrinological investigationTwo siblings with non-classic P450scc deficiency resulted from a novel mutation in CYP11A1 gene misdiagnosed as familial glucocorticoid deficiency.
BMJ case reportsNewly diagnosed autoimmune Addison's disease in a patient with COVID-19 with autoimmune disseminated encephalomyelitis.
BMJ case reportsPrimary adrenal insufficiency and myocarditis in COVID-19 disease: a case report.
BMC endocrine disorders[Hyperpigmentation reveals Addison's disease in a pregnant woman].
Ugeskrift for laegerInsilico prediction and functional analysis of nonsynonymous SNPs in human CTLA4 gene.
Scientific reportsExtreme Hyponatremia Complicated by Osmotic Demyelination in a Previously Healthy Young Individual.
Canadian journal of kidney health and diseaseAddison's disease without hyperpigmentation in pediatrics: pointing towards specific causes.
Hormones (Athens, Greece)Commentary on An Unusual Presentation of Autoimmune Primary Adrenal Insufficiency.
Clinical chemistryAn Unusual Presentation of Autoimmune Primary Adrenal Insufficiency.
Clinical chemistryGrowth alterations in rare forms of primary adrenal insufficiency: a neglected issue in paediatric endocrinology.
EndocrineClinical manifestations and associated factors in acquired hypoaldosteronism in endocrinological practice.
Frontiers in endocrinologyAddison's disease triggered by infection with mycobacterium abscessus, but not by adrenal tuberculosis or MAC pulmonary disease, in a subject with type 2 diabetes mellitus: case report.
BMC endocrine disordersRepeatability assessment of sodium (23Na) MRI at 7.0 T in healthy human calf muscle and preliminary results on tissue sodium concentrations in subjects with Addison's disease.
BMC musculoskeletal disordersBrain structure in autoimmune Addison's disease.
Cerebral cortex (New York, N.Y. : 1991)Broad Complex Tachycardia, Addison's disease, and Ascending Flacid Paralysis: An Interesting Case on Cardiology Floor.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSPPrimary adrenal insufficiency masking as an adrenal B-cell lymphoma.
BMJ case reportsNew Approach to Addison Disease: Oral Manifestations Due to Endocrine Dysfunction and Comorbidity Burden.
Diagnostics (Basel, Switzerland)Intractable vomiting as a presentation of adrenal insufficiency - a case report.
Tropical doctorHigh incidence of null variants identified from newborn screening of X-linked adrenoleukodystrophy in Taiwan.
Molecular genetics and metabolism reportsHyperpigmentation as a clue to Addison disease.
Cleveland Clinic journal of medicineThe short synacthen test: Variations in methodology and protocols in KSA.
Journal of Taibah University Medical SciencesHyponatremia in a patient with diabetic ketosis: Answers.
Pediatric nephrology (Berlin, Germany)Recurrent episodes of vomiting and diarrhoea in a male child: a rare presentation of X-linked adrenoleukodystrophy.
BMJ case reportsHistory of Adrenal Research: From Ancient Anatomy to Contemporary Molecular Biology.
Endocrine reviewsRenin and electrolytes indicate the mineralocorticoid activity of fludrocortisone: a 6 year study in primary adrenal insufficiency.
Journal of endocrinological investigationGNAS mutation is an unusual cause of primary adrenal insufficiency: a case report.
BMC pediatricsLong-term outcomes of conventional and novel steroid replacement therapy on bone health in primary adrenal insufficiency.
Scientific reports[A Novel Pathogenic variant in NR0B1 gene associated with Congenital Adrenal Hypoplasia].
Andes pediatrica : revista Chilena de pediatriaNon-invasive assessment of tissue sodium content in patients with primary adrenal insufficiency.
European journal of endocrinologyPrimary adrenal insufficiency in a patient with biallelic QRSL1 mutations.
European journal of endocrinologyRoutine Screening for Central and Primary Adrenal Insufficiency during Immune-Checkpoint Inhibitor Therapy: An Endocrinology Perspective for Oncologists.
Current oncology (Toronto, Ont.)Lacrimo-auriculo-dento-digital syndrome with AIRE mutation: A case report.
Journal of stomatology, oral and maxillofacial surgeryImmune checkpoint inhibitor-associated new-onset primary adrenal insufficiency: a retrospective analysis using the FAERS.
Journal of endocrinological investigationImpact of hydrocortisone replacement on bone mineral density and bone turnover markers in patients with primary adrenal insufficiency.
Endocrine regulationsAdrenal hemorrhage following direct oral anticoagulant (DOAC) therapy: two case reports and literature review.
Thrombosis journalBilateral Primary Adrenal B-Cell Lymphoma Diagnosed by Workup for Primary Adrenal Deficiency.
The Gulf journal of oncologyThe Staunton case revisited.
The Medico-legal journalClinical Profile of Addison's Disease in a Tertiary Care Institute, Southern India - The Changing Landscape.
Indian journal of endocrinology and metabolismAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
Ainda não temos associações cadastradas para Doença de Addison.
É de uma associação que acompanha esta doença? Fale com a gente →
Comunidades
Grupos ativos de quem convive com esta doença aqui no Raras
Ainda não existe comunidade no Raras para Doença de Addison
Pacientes, familiares e cuidadores se organizam em comunidades pra compartilhar experiências, fazer perguntas e se apoiar. Você pode ser o primeiro.
Tire suas dúvidas
Perguntas, dicas e experiências compartilhadas aqui na página
Participe da discussão
Faça login para postar dúvidas, compartilhar experiências e interagir com especialistas.
Fazer loginDoenças relacionadas
Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico
Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- GDF15 in Patients with Autoimmune Primary Adrenal Insufficiency.
- Clinical features, investigation, and management of Addison's disease.
- Addison-like Clinical Phenotype Without Adrenal Insufficiency: A Rare Manifestation of Pernicious Anemia.
- Allgrove syndrome with early neurodegeneration in a child: A case report from Syria.
- Severe Hyperpigmentation in the Emergency Department.
- Between Crisis and Clarity: Steroid-Induced Psychosis in Addison Disease.
- Adrenocorticotropic Hormone (Cosyntropin) Stimulation Test.
- Dizziness and orthostatic hypotension in a college student.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:85138(Orphanet)
- MONDO:0100480(MONDO)
- Insuficiencia Adrenal Primaria — Doenca de Addison(PCDT · Ministério da Saúde)
- GARD:5740(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
- Q8282(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
