Um tumor na hipófise que pode ou não produzir hormônios, e que não provoca nenhum sintoma relacionado a alterações hormonais.
Introdução
O que você precisa saber de cara
Um tumor na hipófise que pode ou não produzir hormônios, e que não provoca nenhum sintoma relacionado a alterações hormonais.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Entender a doença
Do básico ao detalhe, leia no seu ritmo
Preparando trilha educativa...
Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 26 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 58 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
2 genes identificados com associação a esta condição. Padrão de herança: Not applicable.
Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates
Nucleus
Familial multiple endocrine neoplasia type I
Autosomal dominant disorder characterized by tumors of the parathyroid glands, gastro-intestinal endocrine tissue, the anterior pituitary and other tissues. Cutaneous lesions and nervous-tissue tumors can exist. Prognosis in MEN1 patients is related to hormonal hypersecretion by tumors, such as hypergastrinemia causing severe peptic ulcer disease (Zollinger-Ellison syndrome, ZES), primary hyperparathyroidism, and acute forms of hyperinsulinemia.
May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation
Mitochondrion matrixNucleus
Variantes genéticas (ClinVar)
1,066 variantes patogênicas registradas no ClinVar.
Vias biológicas (Reactome)
11 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Adenoma hipofisário não-secretor
Selecione um estado ou use sua localização para ver resultados.
Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
🟢 Recrutando agora
3 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.
Outros ensaios clínicos
18 ensaios clínicos encontrados, 3 ativos.
Publicações mais relevantes
Oridonin regulates pituitary-derived folliculostellate cells apoptosis via the p38 MAPK/p53 signalling pathway.
Treatment of non-functioning pituitary adenoma remains challenging owing to a lack of effective pharmacological therapies. A previous study has shown that oridonin (ORI) induces apoptosis in pituitary-derived folliculostellate (PDFS) cells; therefore, this study further investigated the molecular mechanisms by which ORI-mediated regulates apoptosis in PDFS cells. To confirm the regulatory role of the p38 mitogen-activated protein kinase (MAPK)/p53 signalling pathway, molecular docking and the p38 MAPK inhibitor SB202190 were used to evaluate pathway modulation. Effects on cell viability, migration, invasion, and apoptosis were evaluated using Calcein-AM/Propidium Iodide (PI) double staining, Transwell migration and invasion assays, and Western blot analysis. To further assess the in vivo effects of ORI, a subcutaneous xenograft model in nude mice was established, and ORI was administered at 5 and 10 mg/kg to assess therapeutic efficacy and safety. Safety was evaluated by analysing histopathological changes in major organs using haematoxylin-eosin (H&E) staining. Western blot analysis of tumour tissues was conducted to assess activation of the p38 MAPK/p53 pathway and the expression of apoptosis-related proteins. Molecular docking and Western blot assays confirmed that ORI binds to p38 protein with an affinity of -7.3 kcal/mol, markedly increasing p38 phosphorylation and p53 expression. The p38 MAPK inhibitor SB202190 reversed ORI-induced effects on cell death, cell migration and invasion, and apoptosis, highlighting the critical role of the p38 MAPK/p53 pathway. ORI effectively suppressed subcutaneous tumour growth in nude mice without notable toxicity while upregulating apoptosis-related proteins Bax and cleaved caspase-3 and downregulating Bcl-2 through activation of the p38 MAPK/p53 pathway.
Sex-related differences in healthcare utilization and costs among patients with pituitary adenomas.
To systematically summarize and evaluate the current evidence regarding sex-based differences in healthcare utilization (HCRU), direct costs, and indirect socioeconomic burden in patients with pituitary adenomas. A systematic literature search of PubMed, EMBASE, and Web of Science identified studies reporting HCRU and/or cost data with sex-stratified analyses. Studies focusing on drug-specific cost-effectiveness, case reports, and scenario-based models were excluded. Eight studies met the inclusion criteria, including non-functioning pituitary adenoma, prolactinoma, acromegaly, Cushing's disease (CD), and perioperative pituitary tumor cohorts from Europe and the United States. Findings were synthesized narratively due to methodological heterogeneity and the scarcity of sex-specific cost estimates. Total and surgical costs did not differ between men and women across most settings in Europe. Only one U.S. acromegaly cohort showed lower adjusted annual costs in women, and one Chinese perioperative patient cohort reported lower inpatient charges among women. In contrast, sex-based differences in HCRU were consistent and clinically relevant: women with acromegaly demonstrated longer diagnostic delays, more pre-diagnostic visits, higher specialist engagement, and more treatment modifications. Perioperatively, sex was not a predictor of length of stay or cost, but several cohorts reported higher rates of cerebrospinal fluid leak, arginine-vasopressin deficiency, and late hyponatremia in women. The most pronounced disparity was observed in indirect socioeconomic burden, with women more frequently experiencing reduced work capacity, early retirement, psychosocial distress, and poorer quality-of-life in acromegaly and CD. Although sex-based differences in overall healthcare costs are limited, women face a disproportionately complex and burdensome care trajectory. Standardized, value-based care pathways may help mitigate these disparities, underscoring the need for prospective, sex-stratified studies.
Sex and Age Differences in Transcription Factor and Hormonal Immunostaining in Patients With Nonfunctioning Pituitary Adenomas.
Nonfunctioning pituitary adenomas (NFPAs) have historically been characterized histologically based on hormonal immunostaining. The 2017 World Health Organization guidelines for pituitary neuroendocrine tumors further delineated NFPA classification based on biologically relevant transcription factors (TFs), including T-PIT, PIT-1, and steroidogenic factor 1 (SF-1). We sought to evaluate differences in NFPA immunohistochemistry (IHC) associated with biological sex and age according to new TF immunostaining criteria. A retrospective review of data from a single institution was conducted to identify patients who had undergone NFPA resection from 2012 to 2023. Patients grouped based on their biological sex and then further divided into age categories. Univariable statistics were used to identify associations between patient demographics and NFPA IHC. A total of 416 patients were included in the IHC-hormone analysis, and 154 patients were included in the IHC-TF analysis. Men were significantly less likely to have NFPAs with positive immunostaining for T-PIT (odds ratio [OR] = 0.15, 95% CI: 0.06-0.37) or adrenocorticotropic hormone (OR = 0.38, 95% CI: 0.22-0.64) and significantly more likely to have NFPAs stain positive for SF-1 (OR = 4.87, 95% CI: 2.24-10.6), follicle-stimulating hormone (FSH) (OR = 2.46, 95% CI: 1.64-3.69), luteinizing hormone (OR = 2.28, 95% CI: 1.26-4.13), thyroid-stimulating hormone (OR = 2.56, 95% CI: 1.05-6.26), or the alpha subunit (OR = 2.01, 95% CI: 1.36-2.97). Compared with the youngest age group, women in the oldest age group were more likely to have an NFPA stain positive for SF-1 (OR = 6.88, 95% CI: 1.86-25.4), FSH (OR = 2.32, 95% CI: 1.02-5.27), or the alpha subunit (OR = 2.14, 95% CI: 1.02-4.47). Similarly, men in the oldest age group were more likely to have an NFPA staining positive for FSH (OR = 4.16, 95% CI: 1.90-9.11) and the alpha subunit (OR = 2.36, 95% CI: 1.10-5.05); they were less likely to have positive immunostaining for adrenocorticotropic hormone (OR = 0.19, 95% CI: 0.04-0.79). There were no age-related differences in TF staining for male patients. This study demonstrates that sex and age are important demographic factors associated with immunostaining patterns and TF lineage subtypes for NFPAs. Underlying endocrine factors dictated by age and sex may represent a role in tumorigenesis or progression of NFPAs.
Clinicopathological features and outcomes in non-functioning pituitary neuroendocrine tumors: a transcription factor-driven subtype analysis.
To assess the differences in clinicopathological features and outcomes of non-functioning pituitary neuroendocrine tumors (PitNETs) based on transcription factor expression. Clinical data were collected from patients diagnosed with non-functioning PitNETs at our hospital. Tumors were classified into transcription factor-based subgroups for comparison. Clinical characteristics were analyzed across these subgroups, and prognostic data were obtained through postoperative outpatient records and telephone follow-ups. A total of 409 patients were included, comprising 202 males (49.4%) and 207 females (50.6%). Of these, 245 (59.9%), 101 (24.7%), 39 (9.5%), and 24 (5.9%) patients were classified into the steroidogenic factor-1 (SF1), T-box transcription factor 19 (TPIT), POU class 1 homeobox 1 (PIT1), and no distinct lineage groups, respectively. The SF1 subgroup was associated with lipid metabolism disorders. The TPIT subgroup had the largest and most invasive tumors. Patients in the PIT1 and no distinct lineage groups were more likely to present with hyperprolactinemia and galactorrhea and showed a lower tendency to invade the cavernous sinus. The median follow-up duration was 801 days. The PIT1 and TPIT subgroups had shorter tumor-free survival, particularly the former. Further survival analysis revealed that patients with TPIT and PIT1 lineages had poorer prognoses. Transcription factor expression was associated with distinct clinical features and short-term outcomes. The PIT1 and TPIT lineages were linked to shorter tumor-free survival. Enhanced postoperative surveillance is recommended for these subgroups. These findings underscore the clinical and prognostic heterogeneity of non-functioning PitNETs.
Impact of sex on mortality in patients with pituitary adenomas.
Publicações recentes
Hypogonadotropic Hypogonadism Before and After Transsphenoidal Surgery for Non-Functioning Pituitary Adenoma.
The impact of a non-functioning pituitary adenoma on life - A qualitative study of patients' experiences.
Natural history of non-functioning pituitary neuroendocrine tumours: impact of baseline characteristics and gender-specific clinical presentations.
Risk factors for pituitary apoplexy: a meta-analysis and development of a clinical prediction nomogram.
Integrated proteomic and metabolomic profiling reveals molecular signatures underlying invasiveness in non-functioning pituitary adenomas.
📚 EuropePMC136 artigos no totalmostrando 198
Oridonin regulates pituitary-derived folliculostellate cells apoptosis via the p38 MAPK/p53 signalling pathway.
European journal of pharmacologySex-related differences in healthcare utilization and costs among patients with pituitary adenomas.
PituitaryImpact of sex on mortality in patients with pituitary adenomas.
PituitarySex and Age Differences in Transcription Factor and Hormonal Immunostaining in Patients With Nonfunctioning Pituitary Adenomas.
Operative neurosurgery (Hagerstown, Md.)Clinicopathological features and outcomes in non-functioning pituitary neuroendocrine tumors: a transcription factor-driven subtype analysis.
Journal of neuro-oncologyClinical, radiological, and pathological characteristics and long-term outcomes of silent corticotroph adenomas: a retrospective study.
BMC endocrine disordersManaging Atopic Dermatitis with Dupilumab in Special Populations: A Case Series Study.
Clinical, cosmetic and investigational dermatologyIntensity-Modulated Proton Therapy for an Unresectable Giant Non-functioning Pituitary Adenoma: A Case Report and Literature Review.
CureusNeurocognitive evaluation of patients with non-functioning pituitary adenoma.
PituitaryThe association between sleep quality and cognitive function in patients with non-functioning pituitary adenoma.
Endocrine connectionsAutoimmune thyroid disease and pituitary adenoma in a female patient with 18p deletion syndrome: a case report and review of the literature.
BMC endocrine disordersIsolated syndrome of inappropriate antidiuresis (SIAD) after Transphenoidal surgery of a non-functioning pituitary adenoma: clinical case report.
Oxford medical case reportsAnemia in Patients With Pituitary Adenomas: Prevalence and Correlation With Hypopituitarism.
CureusVenous thromboembolism in patients with pituitary adenoma: UK multicentre cohort study.
European journal of endocrinologyEEA for sellar chodrosarcomas: case series with literature review.
Chinese neurosurgical journalBaseline testosterone levels as a predictor of hypogonadism resolution in male patients with isolated hyperprolactinemia.
PituitaryPANOMEN-3 grading score is reliable in predicting pituitary adenoma behavior and prognosis: a single center cohort study.
EndocrineHeadache as an indication for surgery in non-functioning pituitary adenoma and Rathke's cleft cyst: A systematic review.
Clinical neurology and neurosurgerySoluble alpha klotho-impact of biological variables and reference intervals for adults.
European journal of endocrinologyConservatively managed non-functioning pituitary macroadenomas-cohort study from the UK Non-functioning Pituitary Adenoma Consortium.
European journal of endocrinologyMetformin induces apoptosis in pituitary-derived folliculostellate cells via the IL-6/ERK pathway.
Discover oncologyImpulse control disorders in patients with pituitary adenoma managed with or without dopamine agonists: a cross-sectional study from a UK centre.
PituitaryIncidental High-Grade Sellar Solitary Fibrous Tumor Mimicking Non-Functioning Pituitary Adenoma: A Case Report and Literature Review.
The American journal of case reportsCoexisting Non-functioning Pituitary Macroadenoma and Sellar-Suprasellar Lipoma: A Case Report and Literature Review.
Acta medica PhilippinaEtiology, presentation, and outcomes of hyperprolactinemia due to pituitary masses in children and adolescents.
EndocrinePerson-centered support for patients with a pituitary tumor following surgery.
Endocrine connectionsKnosp and revised Knosp classifications predict non-functioning pituitary adenoma outcomes: a single tertiary center experience.
Journal of medicine and lifeA case of non-functioning pituitary adenoma with calcification.
Asian journal of surgeryQuality of life in non-functioning pituitary adenoma: A systematic review.
Neurosurgical reviewCognitive decline in Cushing's syndrome: A systematic review.
Journal of neuroendocrinologyComparative mortality in pituitary adenomas subtypes: a tertiary referral center study.
EndocrineBrain Arteriovenous Malformation Hemorrhage and Pituitary Adenoma in a COVID-19-Positive Patient.
CureusPhenotypic presentation of MEN1 c.758delC (p.Ser253Cysfs *28) pathogenic variant: a case report.
Oxford medical case reportsSZ-685C inhibits the growth of non-functioning pituitary adenoma by down-regulating miR-340-3p and inducing autophagy.
HeliyonPituitary apoplexy: a comprehensive analysis of 93 cases across functioning and non-functioning pituitary adenomas from a single-center.
PituitaryLanreotide versus placebo for tumour reduction in patients with a 68Ga-DOTATATE PET-positive, clinically non-functioning pituitary macroadenoma (GALANT study): a randomised, multicentre, phase 3 trial with blinded outcome assessment.
The Lancet regional health. EuropeAmerican Association of Neurological Surgeons/Congress of the Neurological Surgeons Section on Tumors Guidelines: Assessing Their Impact on Brain Tumor Clinical Practice.
NeurosurgeryDifferential expression of cancer-related lncRNAs in different subtypes of pituitary adenomas.
Pathology, research and practiceStem cell-associated transcription factors in non-functioning pituitary neuroendocrine tumours.
Free neuropathologyCardiovascular risk in patients with acromegaly vs. non-functioning pituitary adenoma following pituitary surgery: an active-comparator cohort study.
PituitaryHigh prevalence of morphometric vertebral fractures opportunistically detected on thoracic radiograms in patients with non-functioning pituitary adenoma.
PituitaryGiant Clinically Non-Functioning Pituitary Adenoma Presenting as New Onset Generalized Tonic‒Clonic Seizures: A Case Report.
International medical case reports journalMagnetic Resonance Imaging Features of the Sphenoid Sinus in Patients with Non-Functioning Pituitary Adenoma.
Medicina (Kaunas, Lithuania)Headache in patients with non-functioning pituitary adenoma before and after transsphenoidal surgery - a prospective study.
PituitaryClinical and radiographic characteristics of patients with non-functioning pituitary adenomas categorized according to their serum prolactin concentration: novel predictors of postoperative transient diabetes insipidus following surgery.
EndocrineMedical and Surgical Approaches for a Non-functioning Pituitary Adenoma During Pregnancy.
CureusExcess mortality in patients with non-functioning pituitary adenoma: a systematic review and meta-analysis.
Journal of endocrinological investigationUnique case of lymphocytic hypophysitis with normal pituitary hormone serology mimicking a non-functioning pituitary adenoma.
BMC endocrine disordersPerioperative growth hormone levels as an early predictor of new-onset secondary adrenal insufficiency following transsphenoidal pituitary tumor resection.
Asian journal of surgeryThe correlation among Claudin-9, Tyrosine kinase-2, and Signal transducers and activators of transcription-3 expressions in non-functioning pituitary adenoma and invasiveness.
Neuro endocrinology lettersCabergoline treatment for surgery-naïve non-functioning pituitary macroadenomas.
PituitaryVisual acuity in patients with non-functioning pituitary adenoma: Prognostic factors and long-term outcome after surgery.
Brain & spineSkull Base Collision Tumors: Giant Non-functioning Pituitary Adenoma and Olfactory Groove Meningioma.
CureusNon-functioning pituitary macroadenoma following surgery: long-term outcomes and development of an optimal follow-up strategy.
Frontiers in surgeryExploring endocrinological pitfalls in pituitary surgery in the elderly.
HeliyonPituitary metastasis of hepatocellular carcinoma as the initial presentations: a case report and review of the literature.
Frontiers in oncologyPituitary function at presentation and following therapy in patients with non-functional pituitary macroadenomas: a single centre retrospective cohort study.
EndocrineNatural history of non-functioning pituitary microadenomas: results from the UK non-functioning pituitary adenoma consortium.
European journal of endocrinologyPost-Operative Medium- and Long-Term Endocrine Outcomes in Patients with Non-Functioning Pituitary Adenomas-Machine Learning Analysis.
CancersExpression of LINC00174 in different cancers: Review of the literature and bioinformatics analyses.
Pathology, research and practiceNatural history of pituitary apoplexy: a long-term follow-up study.
Postgraduate medical journalDysregulation of PVT1 and NEAT1 lncRNAs in pituitary adenomas.
Pathology, research and practiceSleep quality in patients with non-functioning pituitary adenoma: impact of replacement therapies with an emphasis on the time of hydrocortisone.
PituitaryHealthcare cost and survival in patients with non-functioning pituitary adenoma.
European journal of endocrinologyUpregulation of MAPKAPK5-AS1, PXN-AS1 and URB1-AS1 lncRNAs in non-functioning pituitary adenoma.
Journal of cellular and molecular medicinePsychiatric disorders and anger in patients with controlled acromegaly.
Minerva endocrinologyLow Bone Density and High Sclerostin in Non-Functioning Pituitary Adenoma.
Journal of clinical densitometry : the official journal of the International Society for Clinical DensitometryEvaluation of preoperative visual pathway impairment in patients with non-functioning pituitary adenoma using diffusion tensor imaging coupled with optical coherence tomography.
Frontiers in neuroscienceCollision of Two Tumors: A Case Report of a Lung Adenocarcinoma With Metastasis to a Pituitary Adenoma.
Journal of the ASEAN Federation of Endocrine SocietiesRisk Factors, Radiological and Clinical Outcomes in Subclinical and Clinical Pituitary Apoplexy.
Journal of clinical medicineChanges in Sinonasal and Overall Quality of Life Following Endoscopic Endonasal Surgery for Non-functioning Pituitary Adenomas: Results of A Prospective Observational Study.
Neurology IndiaSleep patterns in patients treated for non-secreting intra- and parasellar tumors: A self-report case-control study.
Frontiers in endocrinologyPost-operative surveillance for somatotroph, lactotroph and non-functional pituitary adenomas after curative resection: a systematic review.
PituitaryEffect of cabergoline on tumor remnant after surgery in nonfunctioning pituitary adenoma.
Journal of neuro-oncologyEpigenomic and transcriptomic landscaping unraveled candidate repositioned therapeutics for non-functioning pituitary neuroendocrine tumors.
Journal of endocrinological investigationImpact of histopathological classification of non-functioning adenomas on long term outcomes: comparison of the 2004 and 2017 WHO classifications.
PituitaryManagement after initial surgery of nonfunctioning pituitary adenoma: surveillance, radiotherapy or surgery?
Radiation oncology (London, England)DNA Methylation Profiling in Rare Sellar Tumors.
BiomedicinesA Factorial Analysis on Visual Outcomes of Transsphenoidal Surgery for Pituitary Macroadenoma.
Asian journal of neurosurgeryExpression pattern of non-coding RNAs in non-functioning pituitary adenoma.
Frontiers in oncologyEndoscopic transsphenoidal surgery for non-functioning pituitary adenoma: Learning curve and surgical results in a prospective series during initial experience.
Frontiers in surgeryTreatment of non-functioning pituitary adenoma with cabergoline: a systematic review and meta-analysis.
PituitaryA systematic review of molecular alterations in invasive non-functioning pituitary adenoma.
EndocrineSevoflurane anesthesia rather than propofol anesthesia is associated with 3-month postoperative hypocortisolism in patients undergoing endoscopic transsphenoidal surgery for non-functional pituitary adenoma with preoperative normal hypothalamic-pituitary-adrenal axis.
Acta neurochirurgicaAssociation between overweight and growth hormone secretion in patients with non-functioning pituitary tumors.
PloS oneDiscrimination between non-functioning pituitary adenomas and hypophysitis using machine learning methods based on magnetic resonance imaging‑derived texture features.
PituitaryEctopic Cushing's syndrome from an ACTH-producing pheochromocytoma with a non-functioning pituitary adenoma.
Endocrinology, diabetes & metabolism case reportsMultivariable Diagnostic Prediction Model to Detect Hormone Secretion Profile From T2W MRI Radiomics with Artificial Neural Networks in Pituitary Adenomas.
Medeniyet medical journalLate onset of pituitary apoplexy following gonadotropin-releasing hormone agonist for prostate cancer treatment.
BMJ case reportsDeterminants of Short-Term Weight Gain Following Surgical Treatment for Craniopharyngioma in Adults.
Journal of Korean Neurosurgical SocietyRole of microRNAs in non-functioning pituitary adenoma.
JPMA. The Journal of the Pakistan Medical AssociationMetachronous Double Pituitary Adenoma with Altered Transcriptional Factor Profile: A Case Report and Literature Review.
NMC case report journalHemostasis through Extended Transsphenoidal Route for Subarachnoid Hemorrhage after Conventional Transsphenoidal Surgery for a Pituitary Adenoma.
NMC case report journalGamma knife radiosurgery in pituitary adenomas. A single-center experience.
MedicinaAn Update on Silent Corticotroph Adenomas: Diagnosis, Mechanisms, Clinical Features, and Management.
CancersA Novel Three-LncRNA Signature Predicting Tumor Recurrence in Nonfunctioning Pituitary Adenomas.
Frontiers in geneticsPseudocapsular resection in elderly patients with non-functioning pituitary adenoma.
Clinical neurology and neurosurgeryMachine-Learning Prediction of Postoperative Pituitary Hormonal Outcomes in Nonfunctioning Pituitary Adenomas: A Multicenter Study.
Frontiers in endocrinologyBaseline MRI findings as predictors of hypopituitarism in patients with non-functioning pituitary adenomas.
Endocrine connectionsCardiovascular risk profile in growth hormone-treated adults with craniopharyngioma compared to non-functioning pituitary adenoma: a national cohort study.
European journal of endocrinologyIsolated Neuropsychiatric Features with Non-functioning Pituitary Adenoma: Association or Coincidence?
Journal of pediatric neurosciencesPseudo-Cushing's state in a patient with non-functioning pituitary adenoma.
BMJ case reportsStereotactic Radiosurgery and Hypofractionated Stereotactic Radiotherapy for Nonfunctioning Pituitary Adenoma.
Journal of neurological surgery. Part B, Skull baseSafety of growth hormone (GH) treatment in GH deficient children and adults treated for cancer and non-malignant intracranial tumors-a review of research and clinical practice.
PituitaryPredictive factors of postoperative diabetes insipidus in 333 patients undergoing transsphenoidal surgery for non-functioning pituitary adenoma.
PituitaryThe open sella technique for surgical treatment of pituitary macroadenomas: Safety and efficacy in a large clinical series.
British journal of neurosurgeryGiant Recurrence Pituitary Adenoma After Three Times Transphenoidal Removal Surgery, One Craniotomy Procedure, and 30 Doses of External Radiotherapy.
Acta medica IndonesianaSphenoid sinus mucosal thickening in patients with non-functioning pituitary adenoma.
International journal of clinical practicePituitary Hormonal Status after Endoscopic Endonasal Transphenoidal Removal of Nonfunctioning Pituitary Adenoma: 5 years' Experience in a Single Center.
Asian journal of neurosurgeryNon-functioning pituitary adenomas and pregnancy: one-center experience and review of the literature.
Archives of endocrinology and metabolismEarly hormonal recovery following endoscopic transsphenoidal surgery for silent non-functioning pituitary adenomas with hormone dysfunction.
Journal of neuro-oncologyScreening and Identification of Key Microenvironment-Related Genes in Non-functioning Pituitary Adenoma.
Frontiers in geneticsRapid resolution of a third nerve palsy from pituitary apoplexy.
BMJ case reportsQuality of Life and Sleep in Patients with Pituitary Adenoma in Relation to Tumor Type and Compression of the Optic Chiasm.
Journal of clinical medicineRole of pituitary stalk and gland radiological status on endocrine function and outcome after endoscopic transsphenoidal surgery for non-functioning pituitary adenomas.
EndocrineGH-induced LH hyporesponsiveness as a potential mechanism for hypogonadism in male patients with acromegaly.
Endocrine journalA comparative study of functioning and non-functioning pituitary adenomas.
MedicineNomogram predictive model of post-operative recurrence in non-functioning pituitary adenoma.
Gland surgeryIdentifying critical protein-coding genes and long non-coding RNAs in non-functioning pituitary adenoma recurrence.
Oncology lettersClinical Parameters of Silent Corticotroph Adenomas With Positive and Negative Adrenocorticotropic Hormone Immunostaining: A Large Retrospective Single-Center Study of 105 Cases.
Frontiers in endocrinologyPractice patterns in the management of recurrent and residual non-functioning pituitary adenomas: Results from a Canada-wide survey.
eNeurologicalSciDome-Shaped Pituitary Enlargement in Primary Hypothyroidism: Avoiding Neurosurgical Interventions.
Journal of the ASEAN Federation of Endocrine SocietiesESE audit on management of Adult Growth Hormone Deficiency in clinical practice.
European journal of endocrinologyPseudoacromegaly Associated with Non-Functioning Pituitary Adenoma.
European journal of case reports in internal medicineChromosomal and oxidative DNA damage in non-functioning pituitary adenomas.
Endokrynologia PolskaCephalocaudal tumor diameter is a predictor of diabetes insipidus after endoscopic transsphenoidal surgery for non-functioning pituitary adenoma.
PituitaryChiasmapexy for secondary empty sella syndrome: diagnostic and therapeutic considerations.
PituitaryCharacteristics and clinical outcomes in pituitary incidentalomas and non-incidental pituitary tumors treated with endoscopic transsphenoidal surgery.
MedicineIncidence, mortality, and cardiovascular diseases in pituitary adenoma in Korea: a nationwide population-based study.
PituitaryMRI radiomics for the prediction of recurrence in patients with clinically non-functioning pituitary macroadenomas.
Computers in biology and medicineThe GALANT trial: study protocol of a randomised placebo-controlled trial in patients with a 68Ga -DOTATATE PET-positive, clinically non-functioning pituitary macroadenoma on the effect of lan reotide on t umour size.
BMJ openFull Remission of Long-Term Premenstrual Dysphoric Disorder-Like Symptoms Following Resection of a Pituitary Adenoma: Case Report.
The American journal of case reportsThe quality of life after transnasal microsurgical and endoscopic resection of nonfunctioning pituitary adenoma.
Advances in clinical and experimental medicine : official organ Wroclaw Medical UniversityHealth-related quality of life in patients with non-functioning pituitary adenoma: a special focus on hydrocortisone replacement dose.
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitationCell proliferation, apoptosis, and angiogenesis in non-functional pituitary adenoma: association with tumor invasiveness.
EndocrineCurrent Status of Diagnosis and Management for Functioning Pituitary Tumors: Part I.
Neurology IndiaIdentification of a multidimensional transcriptome signature predicting tumor regrowth of clinically non‑functioning pituitary adenoma.
International journal of oncologyQuality of care evaluation in non-functioning pituitary adenoma with chiasm compression: visual outcomes and timing of intervention clinical recommendations based on a systematic literature review and cohort study.
PituitaryNON-FUNCTIONAL PITUITARY TUMORS: A MISLEADING PRESENTATION OF AN INTRASELLAR PLASMACYTOMA.
Acta endocrinologica (Bucharest, Romania : 2005)The coexistence of recurrent pituitary adenoma and meningioma: case report.
Translational cancer researchComparative analysis of rhinologic outcomes in Cushing disease and non-functioning pituitary adenoma in patients submitted to endoscopic endonasal transsphenoidal surgery.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck SurgeryContent and system development of a digital patient-provider communication tool to support shared decision making in chronic health care: InvolveMe.
BMC medical informatics and decision making68Ga-DOTATATE PET imaging in clinically non-functioning pituitary macroadenomas.
European journal of hybrid imagingIntegrated analysis of DNA methylation and mRNA expression profiles to identify key genes involved in the regrowth of clinically non-functioning pituitary adenoma.
AgingCut-off values for sufficient cortisol response to low dose Short Synacthen Test after surgery for non-functioning pituitary adenoma.
Acta neurochirurgicaGiant Non-Functioning Pituitary Adenoma: Clinical Characteristics and Therapeutic Outcomes.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes AssociationIdentification of key genes in invasive clinically non-functioning pituitary adenoma by integrating analysis of DNA methylation and mRNA expression profiles.
Journal of translational medicinePreoperative growth hormone (GH) peak values during a GH releasing peptide-2 test reflect the severity of hypopituitarism and the postoperative recovery of GH secretion in patients with non-functioning pituitary adenomas.
Endocrine journalMultimodal therapy in aggressive pituitary tumors.
Endocrinologia, diabetes y nutricionPostoperative expression of Cushing disease in a young male: metamorphosis of silent corticotroph adenoma?
Endocrinology, diabetes & metabolism case reportsIdentification of CDK6 and RHOU in Serum Exosome as Biomarkers for the Invasiveness of Non-functioning Pituitary Adenoma.
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chihCavernous sinus haemangioma with intrasellar extension mimicking non-functioning pituitary adenoma - A case report and review of literature.
Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation OncologyThe burden of disease for pituitary patients.
Best practice & research. Clinical endocrinology & metabolismSignificance of Elevated HMGB1 Expression in Pituitary Apoplexy.
Anticancer researchEndocrinological Outcome of Endoscopic Transsphenoidal Surgery for Functioning and Non-Functioning Pituitary Adenoma.
The Malaysian journal of medical sciences : MJMSUnexpected concomitant pituitary adenoma and suprasellar meningioma: a case report and review of the literature.
British journal of neurosurgeryThe pre- and postoperative illness trajectory in patients with pituitary tumours.
Endocrine connectionsPredicting the regrowth of clinically non-functioning pituitary adenoma with a statistical model.
Journal of translational medicineNon-functioning pituitary macroadenoma: surgical outcomes, tumor regrowth, and alterations in pituitary function-3-year experience from the Iranian Pituitary Tumor Registry.
Hormones (Athens, Greece)Identification of Important Invasion-Related Genes in Non-functional Pituitary Adenomas.
Journal of molecular neuroscience : MNQuality of Life but not Cognition is Impacted by Radiotherapy in Patients with Non-Functioning Pituitary Adenoma.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolismeEndocrinological Outcomes of Intraoperative MRI-Guided Endoscopic Transsphenoidal Surgery for Non-Functioning Pituitary Adenoma.
Turkish neurosurgeryIncidence rate and risk factors of early repolarization in patients with growth hormone-secreting pituitary adenoma: a cohort study.
Therapeutics and clinical risk managementAssociation of PTTG1 polymorphism rs1895320, rs2910200 and rs6882742 with non-functioning pituitary adenomas in Chinese Han population: a case-control study.
Metabolic brain diseaseRecurrence in silent corticotroph adenomas after primary treatment: A systematic review and meta-analysis.
The Journal of clinical endocrinology and metabolismA two‑circRNA signature predicts tumour recurrence in clinical non‑functioning pituitary adenoma.
Oncology reportsGenome-wide identification of lncRNAs and mRNAs differentially expressed in non-functioning pituitary adenoma and construction of an lncRNA-mRNA co-expression network.
Biology openSpindle cell oncocytoma of the neurohypophysis with metastasis to the sphenoparietal sinus and immunohistochemical negativity for S100 and epithelial membrane antigen (EMA).
British journal of neurosurgeryAutoimmune thyroid diseases are more common in patients with prolactinomas: a retrospective case-control study in an Italian cohort.
Journal of endocrinological investigationComorbidities in patients with non-functioning pituitary adenoma: influence of long-term growth hormone replacement.
European journal of endocrinologyFGFR2 gene polymorphism rs2981582 is associated with non-functioning pituitary adenomas in Chinese Han population: a case-control study.
Bioscience reportsSpectrum of Pituitary disorders: A retrospective study from Basrah, Iraq.
F1000ResearchPostoperative growth hormone dynamics in clinically nonfunctioning pituitary adenoma.
Endocrine journalGiant pituitary adenoma: histological types, clinical features and therapeutic approaches.
EndocrineData of phosphoproteomic analysis of non-functioning pituitary adenoma.
Data in briefClinical and epidemiological characteristics of pituitary tumours in a single centre in Saudi Arabia.
Hormones (Athens, Greece)Interpretation of Serum Gonadotropin Levels in Hyperprolactinaemia.
NeuroendocrinologyRecurrent non-functioning pituitary adenomas: a review on the new pathological classification, management guidelines and treatment options.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of MexicoNon-invasive radiomics approach potentially predicts non-functioning pituitary adenomas subtypes before surgery.
European radiologyEffects of active acromegaly on bone mRNA and microRNA expression patterns.
European journal of endocrinologyMortality in patients with non-functioning pituitary adenoma.
PituitaryManagement of NFAs: medical treatment.
PituitaryMid-term prognosis of non-functioning pituitary adenomas with high proliferative potential: really an aggressive variant?
Journal of neuro-oncologyHow non-functioning pituitary adenomas can affect health-related quality of life: a conceptual model and literature review.
PituitaryA novel "total pituitary hormone index" as an indicator of postoperative pituitary function in patients undergoing resection of pituitary adenomas.
OncotargetLimitations of high throughput methods for miRNA expression profiles in non-functioning pituitary adenomas.
Pathology oncology research : PORUtility of Pit-1 Immunostaining in Distinguishing Pituitary Adenomas of Primitive Differentiation from Null Cell Adenomas.
Endocrine pathologyAmelanotic melanocytoma of the sella mimicking pituitary adenoma.
Clinical neuropathologyPrevalence, Clinical Features, and Natural History of Incidental Clinically Non-Functioning Pituitary Adenomas.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolismeAll that glitters on PET is not cancer! 18F-deoxy-glucose avidity versus tumor biology: pituitary incidentaloma in a survivor of two previous unrelated malignancies.
Endokrynologia PolskaIn-frame seven amino-acid duplication in AIP arose over the last 3000 years, disrupts protein interaction and stability and is associated with gigantism.
European journal of endocrinologyHigher glucocorticoid replacement doses are associated with increased mortality in patients with pituitary adenoma.
European journal of endocrinologyEarly postoperative growth in non-functioning pituitary adenomas; A tool to tailor safe follow-up.
EndocrineThe impact on cognitive functions of patients with pituitary adenoma before and after surgery.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical NeurophysiologyNon-functioning pituitary adenoma underwent surgery: A multicenter retrospective study over the last four decades (1977-2015).
European journal of internal medicineNovel Biomarkers for Non-functioning Invasive Pituitary Adenomas were Identified by Using Analysis of microRNAs Expression Profile.
Biochemical geneticsPituitary Carcinoma in a Patient with an SDHB Mutation.
Endocrine pathologyIncidence of malignant tumours in patients with a non-functioning pituitary adenoma.
Endocrine-related cancerAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
Ainda não temos associações cadastradas para Adenoma hipofisário não-secretor.
É de uma associação que acompanha esta doença? Fale com a gente →
Comunidades
Grupos ativos de quem convive com esta doença aqui no Raras
Ainda não existe comunidade no Raras para Adenoma hipofisário não-secretor
Pacientes, familiares e cuidadores se organizam em comunidades pra compartilhar experiências, fazer perguntas e se apoiar. Você pode ser o primeiro.
Tire suas dúvidas
Perguntas, dicas e experiências compartilhadas aqui na página
Participe da discussão
Faça login para postar dúvidas, compartilhar experiências e interagir com especialistas.
Fazer loginDoenças relacionadas
Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico
Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Oridonin regulates pituitary-derived folliculostellate cells apoptosis via the p38 MAPK/p53 signalling pathway.
- Sex-related differences in healthcare utilization and costs among patients with pituitary adenomas.
- Sex and Age Differences in Transcription Factor and Hormonal Immunostaining in Patients With Nonfunctioning Pituitary Adenomas.
- Clinicopathological features and outcomes in non-functioning pituitary neuroendocrine tumors: a transcription factor-driven subtype analysis.
- Impact of sex on mortality in patients with pituitary adenomas.
- Hypogonadotropic Hypogonadism Before and After Transsphenoidal Surgery for Non-Functioning Pituitary Adenoma.
- The impact of a non-functioning pituitary adenoma on life - A qualitative study of patients' experiences.
- Natural history of non-functioning pituitary neuroendocrine tumours: impact of baseline characteristics and gender-specific clinical presentations.
- Risk factors for pituitary apoplexy: a meta-analysis and development of a clinical prediction nomogram.
- Integrated proteomic and metabolomic profiling reveals molecular signatures underlying invasiveness in non-functioning pituitary adenomas.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:91349(Orphanet)
- MONDO:0019613(MONDO)
- GARD:19159(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Q18556965(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
