Processo inflamatório agudo que afeta o parênquima cerebral. As causas incluem infecções virais e, menos frequentemente, infecções bacterianas, toxinas e processos imunomediados.
Introdução
O que você precisa saber de cara
Processo inflamatório agudo que afeta o parênquima cerebral. As causas incluem infecções virais e, menos frequentemente, infecções bacterianas, toxinas e processos imunomediados.
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 176 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 335 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
7 genes identificados com associação a esta condição.
Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites (PubMed:20538056, PubMed:24780397). Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters (PubMed:20538056)
Mitochondrion inner membrane
Carnitine palmitoyltransferase 2 deficiency, myopathic, stress-induced
An autosomal recessive disorder of mitochondrial long-chain fatty acid oxidation, characterized by recurrent myoglobinuria, episodes of muscle pain, stiffness, and rhabdomyolysis. These symptoms are exacerbated by prolonged exercise, fasting, cold, or viral infection. CPT2DM affects most frequently children or young adults, and severity of attacks is highly variable. Myoglobinuria can cause kidney failure and death.
E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific dockin
NucleusNucleus membraneNucleus, nuclear pore complexNucleus envelope
Encephalopathy, acute, infection-induced, 3
A rapidly progressive encephalopathy manifesting in susceptible individuals with seizures and coma. It can occur within days in otherwise healthy children after common viral infections such as influenza and parainfluenza, without evidence of viral infection of the brain or inflammatory cell infiltration. Brain T2-weighted magnetic resonance imaging reveals characteristic symmetric lesions present in the thalami, pons and brainstem.
Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:10581243, PubMed:11839743, PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:15485837, PubMed:18583960, PubMed:21138416, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:25636800, PubMed:26611359, PubMed:32404352, PubMed:34363755, PubMed:32298923). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 a
Cytoplasm
Glaucoma 1, open angle, P
A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. GLC1P is characterized by early onset, thin central corneas and low intraocular pressure.
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response
Endoplasmic reticulum membraneEndosome membraneEarly endosome
Immunodeficiency 83, susceptibility to viral infections
An immunologic disorder characterized by increased susceptibility to severe viral infections, including herpes simplex virus (HSV), varicella zoster virus (VZV), influenza A virus (IAV), hantavirus, and possibly respiratory syncytial virus (RSV). IMD83 clinical manifestations include acute infection-induced encephalitis and pneumonitis. The susceptibility to encephalitis or pneumonitis appears to result from impaired TLR3-dependent interferon production by nonhematopoietic cells that reside within the central nervous system or lung epithelial cells. IMD83 transmission pattern is consistent with autosomal dominant or autosomal recessive inheritance with incomplete penetrance.
Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis (PubMed:12471095, PubMed:12539043, PubMed:14739303, PubMed:28747347, PubMed:35215908). Ligand binding to these receptors results in TRIF recruitment through its TIR domain (PubMed:12471095, PubMed:12539043, PubMed:14739303). Distinct protein-interaction motifs allow recruitment of the effector
Cytoplasmic vesicle, autophagosomeCytoplasm, cytosolMitochondrion
Encephalopathy, acute, infection-induced, 6, herpes-specific
A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. It is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome.
Cytoplasmic E3 ubiquitin ligase that regulates various signaling pathways, such as the NF-kappa-B, mitogen-activated protein kinase (MAPK) and interferon regulatory factor (IRF) pathways, and thus controls a lot of biological processes in both immune and non-immune cell types (PubMed:33148796, PubMed:33608556). In TLR and RLR signaling pathways, acts as an E3 ubiquitin ligase promoting the synthesis of 'Lys-63'-linked polyubiquitin chains on several substrates such as ASC that lead to the activa
CytoplasmEndosomeMitochondrion
Immunodeficiency 132A
An autosomal dominant immunologic disorder characterized by increased susceptibility to infection with certain pathogens, including Herpes simplex virus and Mycobacterium abscessus. Immunologic work-up shows impaired production of cytokines, including INFB and IL6.
Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal
Endoplasmic reticulum membraneEndosomeLysosomeCytoplasmic vesicle, phagosome
Encephalopathy, acute, infection-induced, 1, herpes-specific
A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. It is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome.
Medicamentos e terapias
Mecanismo: IL6Ralpha/GP130 antagonist
Mecanismo: Glucocorticoid receptor agonist
Mecanismo: Glucocorticoid receptor agonist
Mecanismo: Programmed cell death protein 1 inhibitor
Mecanismo: B-lymphocyte antigen CD20 binding agent
Mecanismo: Inosine-5'-monophosphate dehydrogenase 1 inhibitor
Mecanismo: B-lymphocyte antigen CD19 binding agent
Mecanismo: B-lymphocyte antigen CD20 binding agent
Mecanismo: Interleukin-2 receptor agonist
Variantes genéticas (ClinVar)
734 variantes patogênicas registradas no ClinVar.
Classificação de variantes (ClinVar)
Distribuição de 1,799 variantes classificadas pelo ClinVar.
Vias biológicas (Reactome)
71 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
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Outros ensaios clínicos
418 ensaios clínicos encontrados, 27 ativos.
Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 23.325
Fixel-Based Analysis of Pretreatment MRI Identifies White Matter Abnormalities in Pediatric Anti-NMDAR Encephalitis.
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is an autoimmune disorder in which conventional MRI often appears normal, leading to clinical-radiologic dissociation and hindering early diagnosis and monitoring. We retrospectively studied five pediatric patients with anti-NMDAR encephalitis and compared their pretreatment diffusion MRI to age- and sex-matched controls. Using fixel-based analysis (FBA), we quantified tract-specific white matter abnormalities at the individual level. All patients showed significantly reduced fiber density and cross-section, with patterns ranging from focal to widespread involvement. In two patients, FBA abnormalities corresponded to seizure lateralization on EEG despite normal MRI, emphasizing FBA's added value in detecting seizure-concordant injury. One patient, exhibiting the highest disease burden and marked CSF pleocytosis, demonstrated extensive white matter tract disruption. These findings indicate that FBA derived from pretreatment MRI can identify clinically significant white matter injury at disease onset in pediatric anti-NMDAR encephalitis. Future large-scale studies should explore its potential as an individualized biomarker, which may offer diagnostic and prognostic value beyond conventional imaging.
[18F]Fluorodeprenyl-D2 PET as a Tool to Monitor Disease Activity in GAD65-Ab Autoimmune Encephalitis.
To evaluate [18F]fluorodeprenyl-D2 ([18F]F-DED) positron-emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. [18F]F-DED PET was performed in 25 GAD65-AIE patients and 8 controls using dynamic (0-60 min) and static (30-60 min) acquisitions. Global astrogliosis was assessed by volumes of distribution (VT; 1-tissue-compartment model with carotid input) and standardized uptake values (SUV). Regional cerebellar and mesiotemporal (MT) uptake was normalized to global uptake (SUVr). PET measures were correlated with clinical phenotypes, MRI findings, and serum biomarkers (neurofilament light chain [sNfL], GAD65-Ab titers, and glial fibrillary acidic protein [sGFAP]). Clinical phenotypes included limbic encephalitis/temporal lobe epilepsy (LE/TLE; n = 17), stiff-person syndrome (n = 4), and cerebellar ataxia (CA; n = 4), with overlap in nine patients. Global [18F]F-DED uptake was higher in patients than controls. VT analysis showed increased cortical and MT uptake, while SUVr analysis demonstrated elevated MT uptake across the cohort. LE/TLE patients exhibited increased MT uptake, and CA patients showed higher cerebellar uptake. [18F]F-DED uptake did not correlate with sNfL or GAD65-Ab titers, but sGFAP showed associations with cerebellar and white-matter uptake. Regional uptake correlated with clinical severity in LE/TLE (MT lobe) and CA (cerebellar white matter). [18F]F-DED PET reveals region-specific astrogliosis corresponding to clinical manifestations and disease severity in GAD65-AIE, supporting its potential as a monitoring tool for disease activity.
Population-Based Epidemiology of Autoimmune Seizures and Epilepsies.
To estimate the prevalence, incidence, and disease burden of autoimmune seizures and epilepsies in Olmsted County. We conducted a retrospective, population-based study using the Rochester Epidemiology Project (1996-2019). Age- and sex-standardized rates (2019 United States standard population) per 100,000 were calculated with 95% confidence intervals (95% CIs). Temporal trends in incidence were assessed over 3 consecutive 8-year intervals (1996-2003, 2004-2011, and 2012-2019) using Poisson regression to estimate rate ratios per period and trend. Disability-adjusted life years (DALYs), years of life lost (YLL), and years lived with disability (YLD) and 95% uncertainty intervals (95% UIs) were estimated for 2019. Twenty-three patients were identified between 1996 and 2019. In 2019, the standardized prevalence of all autoimmune seizures and epilepsies was 9.81 (95% CI, 5.59-15.21) per 100,000, including autoimmune-associated epilepsy (AAE) 7.27 (3.74-11.95) and acute symptomatic seizures secondary to autoimmune encephalitis (ASSAE) 2.55 (0.69-5.60). From 1996 to 2019, the standardized incidence was 0.50 (0.29-0.77) per 100,000 person-years overall, with AAE 0.36 (0.19-0.59) and ASSAE 0.15 (0.05-0.30). By period, the standardized incidence of all autoimmune seizures and epilepsies suggested a rising trend from 0.28 (95% CI, 0.06-0.68) in 1996 to 2003 to 0.60 (95% CI, 0.24-1.12) in 2004-2011, then plateaued at 0.53 (95% CI, 0.21-1.00) in 2012 to 2019 (rate ratio per 8-year interval 1.30, 95% CI, 0.71-2.38), largely driven by the seropositive subgroup. The standardized DALY rate was 26.27 (95% Uncertainly intervals [UI], 5.30-67.09) per 100,000 (YLL 20.07 [0.00-60.21] and YLD 6.20 [5.06-7.39]). Although autoimmune seizures and epilepsies remain rare, they result in a disproportionately high disease burden. ANN NEUROL 2026.
Inactivated Japanese encephalitis virus vaccination imprints fusion loop-biased antibody responses that are attenuated by repeated live-attenuated dengue vaccination.
Immune imprinting, also known as immune history, is a core aspect of adaptive immunity that influences antibody responses to future antigen exposures. Nevertheless, the impact of sequential flavivirus vaccinations on epitope targeting and antibody activity in humans remains incompletely understood. This question is particularly important in regions where the inactivated Japanese encephalitis virus (JEV) vaccines and the live-attenuated dengue virus (DENV) vaccines are used, as both have been associated with an increased risk of symptomatic dengue infection and severe illness. We studied the impact of prior inactivated JEV IXIARO vaccination and simultaneous vaccination on humoral immunity following live-attenuated dengue CYD-TDV vaccination. Long-term analysis showed that JEV IXIARO priming guides the dengue vaccine-induced antibody response toward conserved fusion loop epitopes (FLEs) of the DENV envelope protein, as indicated by 4G2 FLE-bias. This imprinting was characterized by higher levels of 4G2 FLE-like antibodies, rapid recall responses after dengue vaccination, and broad but low-potency neutralization across dengue serotypes and Zika virus. Notably, 4G2 FLE-focused responses correlated with higher FcγRIIa-mediated antibody-dependent enhancement relative to neutralization potency, suggesting functional effects beyond neutralization. To better understand epitope dominance within the native envelope, we used a structurally defined fusion loop epitope mutant (FLE-mut) envelope dimer assay. Disrupting fusion loop accessibility significantly decreased antibody binding, confirming that FLE-specific antibodies are a major component of the response after sequential vaccination. Importantly, a complete series of live-attenuated dengue vaccine reduced 4G2 FLE bias, encouraged the recruitment of non-fusion-loop epitopes, and lessened FcγRIIa-biased antibody activity. Overall, these results show that vaccination platform, timing, and regimen are critical determinants of epitope dominance and antibody quality following flavivirus vaccination.
Clinico-etiological profile and prognostic factors of acute febrile encephalopathy in children: a prospective study from Indian subcontinent.
Acute febrile encephalopathy (AFE) is a common neurological emergency in all age groups. In tropical regions, long-standing infections such as Japanese encephalitis and bacterial meningitis continue to be major causes of AFE, while changing presentations of familiar infections and newly emerged diseases like COVID-19 are also becoming increasingly notable. To describe various clinical presentations, etiology and mortality of AFE in pediatric age group. This prospective observational study was undertaken in a tertiary care institute of Northern India from April 2022 to April 2023. Children aged 1 month to 18 years presenting to the pediatric emergency department with fever of <2 weeks duration and altered sensorium lasting >24 hours were eligible for inclusion. A total of 100 patients (49% males) with AFE were enrolled. The mean (SD) duration of encephalopathy was 1.39 (0.69) days. The most frequent etiologies were viral encephalitis (17%), dengue encephalopathy (12%), and hepatic encephalopathy (9%). The peak incidence occurred between August and November. The overall case fatality rate was 33%. Under-5 children with severe acute malnutrition (SAM) had the highest fatality rate (56%, 9/16). Among survivors, 16% (11/67) had poor functional outcomes. Higher odds of mortality were observed in patients with a Glasgow coma scale score <8, hypoglycemia at admission, requirement for mechanical ventilation or inotropic support, and presence of multiorgan dysfunction. AFE demonstrates a predictable seasonal pattern and is associated with high mortality and morbidity, particularly in under-5 children with SAM, who represent the most vulnerable group.
Publicações recentes
Anti-Glutamic Acid Decarboxylase 65 (Anti-GAD65) Autoimmune Encephalopathy: A Case of Diagnostic and Treatment Challenge.
Evidence of West Nile virus exposure in healthy donors and a clinical case in an immunocompromised child: emerging public health implications.
Intraventricular hemorrhage, suspected EBV reactivation, and TBA-positive epilepsy after deep cervical lymphovenous anastomosis in Alzheimer's disease: a case report.
One health perspectives on the epidemiological features and changing incidence of natural focus and vector-borne infectious diseases in China: An observational trend study.
Human antibodies against West Nile and related orthoflaviviruses.
📚 EuropePMC31.530 artigos no totalmostrando 199
Fixel-Based Analysis of Pretreatment MRI Identifies White Matter Abnormalities in Pediatric Anti-NMDAR Encephalitis.
Journal of child neurologyCase Report: Immune checkpoint inhibitor-triggered anti-Ma2 paraneoplastic encephalitis in sarcomatoid pleural mesothelioma: a fatal case.
Frontiers in oncologyAnalysis of the Clinical Features of HSV-2 Encephalitis Confirmed by the mNGS Technique: Insights Derived from Seven Patient Studies.
Infection and drug resistanceKnockdown resistance (kdr) mutations in the Japanese encephalitis virus vector Culex tritaeniorhynchus from the Republic of Korea.
Tropical medicine and health[18F]Fluorodeprenyl-D2 PET as a Tool to Monitor Disease Activity in GAD65-Ab Autoimmune Encephalitis.
Annals of clinical and translational neurologyPopulation-Based Epidemiology of Autoimmune Seizures and Epilepsies.
Annals of neurology[A cohort study on the association between lactate to albumin ratio and 28-day in-hospital all-cause mortality in critically ill children].
Zhonghua wei zhong bing ji jiu yi xueConfusion beyond the usual suspects.
Journal of infection and public healthClinical characteristics and surgical outcomes of Rasmussen encephalitis: A retrospective dual-center cohort study.
EpilepsiaInfection and Vaccination-Induced Tick-Borne Encephalitis Virus IgG Antibody Prevalence in the Austrian Federal State of Upper Austria, a High-Risk Region for TBEV.
Epidemiologia (Basel, Switzerland)Concurrent Detection of Streptococcus pneumoniae and Herpes Simplex Virus Type 1 (HSV-1) in Cerebrospinal Fluid: Clinical Interpretation Beyond Molecular Positivity.
CureusSporadic Creutzfeldt-Jakob Disease With Spinal Cord Lesions: A Case Report.
CureusAcute Necrotizing Encephalopathy of Childhood: A Report of Two Cases.
CureusProjecting tick-borne encephalitis risk in Sweden under climate change scenarios: a high-resolution spatio-temporal modeling approach.
Environmental health : a global access science sourceCase Report: Dual response to efgartigimod in myasthenia gravis and comorbid autoimmune disorders: a case series.
Frontiers in immunologyInfluenza A-Associated Acute Necrotizing Encephalitis With Complete Recovery Following Early Immunomodulatory Therapy.
CureusVaricella-Zoster Virus Infection in an Immunocompromised Patient With Seizure-Like Activity and Septic Shock: A Case Report.
CureusUmbelliferone Inhibits Zika Virus (ZIKV) NS5 Activity and Replication In Vitro.
ACS omegaCases of Septic Arthritis During Meningitis Infection at Zinder National Hospital, Niger Republic.
International medical case reports journalInactivated Japanese encephalitis virus vaccination imprints fusion loop-biased antibody responses that are attenuated by repeated live-attenuated dengue vaccination.
medRxiv : the preprint server for health sciencesGlymphatic system dysfunction in epilepsy: a review of mechanisms and clinical evidence.
Encephalitis (Seoul, Korea)Development and evaluation of an assay for the detection of tick-borne encephalitis virus RNA via real-time PCR with reverse transcription.
Parasites & vectorsClinico-etiological profile and prognostic factors of acute febrile encephalopathy in children: a prospective study from Indian subcontinent.
Journal of tropical pediatricsExperimental modeling of Acanthamoeba keratitis in mice: Isolation and cultivation of Acanthamoeba castellanii.
Experimental eye researchRecommendations for a Pediatric Catatonia Clinical Pathway in Acute Medical Care Settings: A Delphi Consensus Study.
Journal of the Academy of Consultation-Liaison PsychiatrySingle-institution experience with efgartigimod in patients with GFAP astrocytopathy: Treatment response and adverse events.
Multiple sclerosis and related disordersTowards national guidance on dengue and chikungunya vaccination in travellers: Lessons from global recommendations.
Travel medicine and infectious diseaseSevere Varicella-Zoster Virus Encephalitis with Extreme Cerebrospinal Fluid Protein Elevation and Delayed Hydrocephalus in an Immunocompetent Patient in Shanghai.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious DiseasesComplications, outcomes, and implications of a prolonged vegetative state in anti-NMDA receptor encephalitis: a retrospective international cohort study.
The Lancet. NeurologyTherapeutic perspectives in refractory anti-NMDA receptor encephalitis.
The Lancet. NeurologyPost-marketing safety evaluation of the live-attenuated chikungunya vaccine (IXCHIQ).
VaccineGlobal burden shift from infectious to non-communicable neurological disorders in adolescents and young adults (10-24 years): findings from the global burden of disease study 1990-2021.
International journal of clinical pharmacyPituitary abscess, plexus-choroiditis and encephalitis by Helcococcus ovis in a calf.
Veterinary research communicationsProgress and Innovation in Japanese Encephalitis Vaccines: Toward Global Immunization.
Recent advances in anti-infective drug discoveryEndoplasmic reticulum stress inhibitor 4-PBA alleviates immune damage in mice with enteroviral encephalitis by inhibiting ferroptosis.
Virology journalClinical characteristics of autoimmune GFAP astrocytopathy with concomitant Epstein-Barr virus positivity: a case series of 12 patients and literature review.
Journal of neurologyVenezuelan equine encephalitis virus: novel live-attenuated vaccines for inducing complete protective immunity.
Npj virusesAn Atypical Presentation of Autoimmune Encephalitis.
The primary care companion for CNS disordersA time-varying geospatial model of habitat suitability for Japanese encephalitis virus vectors and vertebrate hosts in Australia.
PLoS neglected tropical diseasesAnti-NMDA receptor encephalitis in the setting of inherited chromosomally integrated human herpesvirus 6B (iciHHV-6B): A case report.
IDCasesCombination Versus Monotherapy in Acute Anti-LGI1 Encephalitis: A Real-World Dose Optimization Analysis.
Neuropsychopharmacology reportsRegenerative Nodule as a Diagnostic Dilemma in the Neonate With Acute Liver Failure and a Focal Liver Lesion.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology SocietyMyelin-oligodendrocyte glycoprotein antibody-associated cerebral cortical encephalitis initially considered viral meningitis.
QJM : monthly journal of the Association of PhysiciansCentral nervous system pericytes express soluble ST2 in inflammation and injury.
Molecular brainIsolation and characterization of Japanese encephalitis virus genotype I from pig provides evidence for the presence of the virus in nasal secretion and co-circulation of JEV genotypes in Assam, India.
Frontiers in cellular and infection microbiologyClinical profile and treatment outcomes of patients with chronic presentations of autoimmune encephalitis: expanding the spectrum.
BMJ neurology openCat Scratch Disease as an Under-recognised Cause of Subacute Meningitis.
Emerging microbes & infectionsEnterovirus 71: The Emerging Threat of Encephalitis in Nepal.
Journal of Nepal Health Research CouncilAcute cerebral blood flow and its connectivity in patients with anti-LGI1 autoimmune encephalitis: an arterial spin labeling study.
Brain imaging and behaviorVital Prognosis and Causes of Death in Adults with Encephalitis.
Neurocritical careClinical characteristics, laboratory findings, and risk factors for severe tick-borne encephalitis (TBE) in northeastern Poland: analysis of 1654 hospitalized cases between 1993 and 2023.
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Memorias do Instituto Oswaldo CruzClinical Profiles and Outcomes of Adult Patients With Central Nervous System Infections: A Descriptive Cross-Sectional Study at a Single Private Tertiary Hospital in Quezon City, Philippines.
CureusHigh burden of autochthonous arboviral infections during the summer season in Verona province, Italy, during 2025.
The Journal of infectionPathogens of the Human Central Nervous System- the Major Bacterial Pathogens.
Molecular neurobiologySpatial transcriptomics uncovers vasculature-centered cellular interactions driving Japanese encephalitis progression in a mouse model.
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PLoS neglected tropical diseasesSignal peptide variation in cyst lectins as a potential marker for pathogenic Acanthamoeba spp.
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Presse medicale (Paris, France : 1983)Genistein mitigates estrogen deficiency and chronic stress-induced neuronal dysfunction via targeting ER-β, oxidative stress, inflammation, and apoptosis.
Neuromolecular medicineRefractory anti-NMDA receptor encephalitis driven by a contralateral ovarian teratoma following unilateral oophorectomy: a case report.
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Experimental neurologyGAD65 encephalitis presenting with isolated refractory vomiting: a pivotal mimic of functional disorder.
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FASEB journal : official publication of the Federation of American Societies for Experimental BiologyFaster Results, Better Care? Impact of Meningitis/Encephalitis Syndromic Panel Testing on Pathogen Detection and Hospital Outcomes Beyond CSF Culture: A Literature Search for Diagnosticians.
Diagnostics (Basel, Switzerland)The Role of Viral Load in COVID-19-Induced Encephalitis.
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Critical care (London, England)Synaptic dysfunction and adaptation after NMDA receptor ablation in the mouse medial prefrontal cortex.
Neuropsychopharmacology : official publication of the American College of NeuropsychopharmacologyEfficient use of the BioFire® FilmArray® Meningitis/Encephalitis Panel: a diagnostic stewardship approach.
Internal medicine journalDETECTION OF WEST NILE VIRUS AND ST. LOUIS ENCEPHALITIS VIRUS IN THE TEXAS PANHANDLE AND HIGH PLAINS REGION, USA, IN 2024.
Journal of the American Mosquito Control AssociationNon-polio enterovirus infection and electrophysiological changes in human iPSC-derived neural networks.
EBioMedicineEnucleated cells with Nectin-1 overexpression capture HSV-1 and promote viral elimination for herpes simplex encephalitis therapy.
Cell reportsNeuroanatomical localization of faciobrachial dystonic seizures in LGI1-antibody encephalitis.
EpilepsiaModelling Aedes albopictus management, incorporating immigration and bi-directional Wolbachia interactions.
Journal of pest scienceCAR T cell therapy in autoantibody-mediated neurological disorders: a promising strategy.
Journal of neuroinflammationIncidence of Childhood Stroke and Association With Recent Infection: A Population-Based Study Using Linked Data.
NeurologyNeonatal Listeria Meningitis Showing the Limits of the FilmArray Meningitis/Encephalitis Panel® and the Potential Use of Serum.
Indian journal of pediatricsRadiological Features of Encephalitis of Chlamydia psittaci.
Neurology IndiaVisual Disturbance and Elevated Glutamic Acid Decarboxylase Antibody Levels as Manifestations of Central Nervous System Lymphoma.
Neurology IndiaEvaluation of the vector competence of Ixodes persulcatus in the maintenance and transmission of Alongshan virus under laboratory conditions.
Frontiers in cellular and infection microbiologyImprovement of Mycoplasma pneumoniae-Associated Acute Cerebellar Ataxia and Possible Encephalopathy After Intravenous Immunoglobulin.
Case reports in infectious diseasesProteomic Analysis of Serum and Cerebrospinal Fluid in Children with Encephalopathy Associated with Human Betaherpesvirus 6B.
Open forum infectious diseasesBefore status epilepticus in epilepsy patients is attributed to the SARS-CoV-2 vaccination, alternative causes must be ruled out: Status epilepticus after COVID-19 vaccination.
SeizureAlternative diagnoses of suspected paraneoplastic neurological syndromes: a population-based study.
Journal of neurologyCase Report: PET/CT assessment of immunomodulatory therapy in anti-IgLON5 encephalitis with sleep apnea.
Frontiers in neuroscienceMachine learning-based prognostic analysis of patients with status epilepticus in the neurological intensive care unit.
Journal of critical careAdult Japanese encephalitis in a non-endemic area: A case highlighting diagnostic limitations of targeted next-generation sequencing.
Diagnostic microbiology and infectious diseaseJapanese encephalitis virus envelope protein activates the TLR4/NF‑κB pathway to induce testicular inflammation.
Veterinary microbiologyThe Treatment of Antibody-Mediated Encephalitis: Current, Future Therapies, Unmet Need and Patient Management.
Advances in therapyEngineering of cell line assembled enteric organoid for enterovirus infection.
Archives of virologyPost-infectious Basal Ganglia Encephalitis Caused by Mumps: A Case Series.
Journal of child neurologyObservations of the developmental stages of Coquillettidia perturbans (Diptera: Culicidae) with special reference to the pupal trumpets.
Journal of insect science (Online)A Case of Fulminant West Nile Virus Encephalitis Presenting With Non-ST-Segment Elevation Myocardial Infarction (NSTEMI) and Diagnostic Discordance.
CureusLangat Virus Biology and Infection.
Reviews in medical virologyCaffeine for the Treatment of Aseptic Immune Checkpoint Inhibitor-Induced Encephalitis.
The primary care companion for CNS disordersMorvan Syndrome Masquerading as Anxiety Disorder: A Case Report Highlighting the Importance of Recognizing Organic Signs in Psychiatric Settings.
International medical case reports journalReal-World Evaluation of the BioFire FilmArray ME Panel: Diagnostic Accuracy and Clinical Utility.
The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicaleBiosensors for the detection of arthropod-borne veterinary viruses: A comprehensive review.
Veterinary and animal scienceIntrathecal immunoglobulin production in the diagnosis, prognosis, and monitoring of autoimmune diseases of the central nervous system.
Journal of translational autoimmunityNeuropsychiatric Presentation of Non-paraneoplastic Voltage-Gated Calcium Channel Autoimmune Encephalitis: A Case Report.
CureusHerpes Simplex Virus Encephalitis With Cerebellar Infarction and Cortical Laminar Necrosis.
CureusOverview of Immunotherapy Administration for Miller Fisher Syndrome in Japan: A Nationwide Retrospective Cohort Study.
Annals of clinical epidemiologyClinical features, prognosis, and influencing factors of relapse in autoimmune encephalitis associated with antibodies against cell surface antigens: a single-center retrospective study.
European journal of medical researchA human cerebral organoid model of West Nile virus encephalitis shows innate immunocompetency.
Nature communicationsVaricella zoster virus-related myelitis: a case series and literature review.
Virology journalClinico-virological investigation of measles complications in immunocompromised pediatric patients.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseasesMorvan syndrome associated with prominent Tau pathology: A clinicopathological case report.
Journal of neuroimmunologyNon-invasive Assessment of Glymphatic System Function in Patients with Anti-LGI1 Encephalitis.
Multiple sclerosis and related disordersMolecular evidence of Japanese encephalitis virus in poultry: Need to further elucidate JEV epidemiology.
Comparative immunology, microbiology and infectious diseasesAnti-GAD65 Encephalitis: A Cryptic Case Requiring a Multidisciplinary Approach.
Harvard review of psychiatryLRP8-dependent neurotropism of tick-borne encephalitis virus: From species-specific entry gateway to zoonotic spillover and receptor-mimetic therapy.
Innovation (Cambridge (Mass.))Interplay between flaviviruses and the interferon response: mechanisms of immune evasion and therapeutic implications.
Frontiers in pharmacologyNeurological Infections in HIV: A Case-Based Review for Clinicians.
Le infezioni in medicinaClinical characteristics of community acquired pneumonia due to Mycoplasma pneumoniae: experience from an outbreak.
Le infezioni in medicinaAntibody-Negative Nivolumab-Induced Autoimmune Encephalitis: A Case Report and Review of Seronegative Presentations.
CureusIn silico Exploration of Aegle Marmelos-Derived Compounds as Potential Inhibitors of NS5 RdRp in Japanese Encephalitis Virus.
Combinatorial chemistry & high throughput screeningPreliminary evidence of cardiac dysfunction in subacute sclerosing panencephalitis: a systematic review and meta-analysis.
Encephalitis (Seoul, Korea)Clinical utility of a cerebrospinal fluid multiplex PCR meningitis/encephalitis panel in children: a retrospective review of positive results.
BMC infectious diseasesSevere sleep-related hypoventilation in antibody-positive and antibody-negative autoimmune encephalitis: an emergency.
The European respiratory journalWest Nile virus encephalitis in a kidney transplant recipient: a case report and review of the literature.
Clinical transplantation and researchMinimally Clinically Important Difference of the Clinical Assessment Scale in Autoimmune Encephalitis.
Annals of clinical and translational neurologyCentral nervous system disorders following haematopoietic stem cell transplantation: a prospective case-control observational study from the Infectious Diseases Working Party and the Transplant Complications Working Party of EBMT.
EClinicalMedicineSuccessful fresh formulation CD19 CAR-T cell therapy for GAD65 antibody-mediated cerebellar ataxia. A Case Report.
Frontiers in immunologyModulation of innate immune responses by virus-host interactions in Orthoflavivirus.
VirologyEvaluation of the Ultima Genomics UG 100 sequencer for low-cost, high-sensitivity metagenomic pathogen detection from cerebrospinal fluid.
Microbiology spectrumTick-borne encephalitis in the Åland Islands, Finland: incidence and disease course since the implementation of a general TBE vaccination programme.
Emerging microbes & infectionsListeria rhombencephalitis in an alcoholic man; A case report and review of literature.
eNeurologicalSciNivolumab-induced Limbic Encephalitis in Gastric Cancer: A Case Report and Literature Review.
Cancer diagnosis & prognosisRetrospective analysis of the clinical features of 12 cases of MOG antibody-associated aseptic meningitis.
Frontiers in medicineDevelopment and validation of a DNA-launched, intron-stabilized Langat virus infectious clone and reporter viruses.
Virology[Cognitive and psychiatric evolution in autoimmune encephalitis in a school-aged child: Clinical case].
Revista medica del Instituto Mexicano del Seguro SocialInvestigation of tick-borne encephalitis virus in raw ruminant milk in Turkiye using real-time PCR.
Archives of virologyDeciphering Involuntary Movements: A Case of Seronegative Autoimmune Encephalitis With a Kaleidoscopic Presentation.
CureusBrainstem encephalitis and anti-GQ1b antibody syndrome triggered by varicella-zoster virus presenting as intractable hiccups: a first reported case.
BMC neurologyNeuropathogenesis of Usutu virus-associated disease in Eurasian blackbirds (Turdus merula) involves apoptosis through the extrinsic pathway.
Journal of neurovirologyChronic granulomatosis with persistent HSV intrathecal synthesis over three years: a rare complication of HSV encephalitis in adult.
Journal of neurovirologySingle-cell transcriptomics reveal heat shock protein dysregulation in severe SARS-CoV-2-associated pediatric encephalopathy.
Scientific reportsSjögren Syndrome Associated Limbic Encephalitis and Its Longitudinal Brain FDG PET Manifestations.
Clinical nuclear medicineOptimization of lytic herpes simplex virus infection in human induced pluripotent stem cell-derived cortical neurones.
The Journal of general virologyChandipura Virus: A Neglected Sandfly-Borne Neurotropic Virus in Children - Insights From Seven Decades of Evidence.
Reviews in medical virologyNeuropsychiatric Systemic Lupus Erythematosus Diagnosed Following Treatment Initiated for Acute Encephalitis.
CureusHHV-6 Encephalitis in an Immunocompetent Child: A Steroid-Responsive Case Complicated by Cerebral Venous Sinus Thrombosis.
Sage open pediatricsFunctional Hemispherectomy for Rasmussen Encephalitis in a Patient with Systemic Lupus Erythematosus and Type 1 Diabetes Mellitus: A Case Report.
International medical case reports journalGlobal, regional, and national burden of encephalitis from 1990 to 2021: result from the global burden of disease study 2021.
Frontiers in neurologyMagnetic Resonance and Computed Tomographic Findings in a Case of Encephaloclastic Porencephaly in a Sulawesi Crested Macaque.
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology AssociationHeadache in a Patient with Anti-Leucine-Rich Glioma Inactivated 1 Autoimmune Encephalitis Responding to Rituximab.
Annals of Indian Academy of NeurologyNeuropsychiatric Complications of Allopurinol-Induced DRESS syndrome.
Journal of the Academy of Consultation-Liaison PsychiatryHerpetic panophthalmitis in a patient with a history of neonatal herpetic encephalitis.
Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and StrabismusUse of tocilizumab in acute necrotising encephalitis secondary to influenza A.
NeurologiaAssessment of lipid mediators in the urine of patients with Lyme disease, tick-borne encephalitis and human granulocytic anaplasmosis.
Scientific reportsNeuronal autoantibodies in neurodegenerative dementia: From evidence to clinical framework.
The journal of prevention of Alzheimer's diseaseMachine learning model predicts prognosis in SARS-CoV-2-infected autoimmune encephalitis patients.
Multiple sclerosis and related disordersRethinking rituximab in neuroimmunology: Real-world efficacy, cost-effectiveness, and long-term remission.
Journal of neuroimmunologyRocio virus sustained circulation in Brazil: first infection case in a horse highlights the need for enhanced arbovirus surveillance.
Archives of virologySpillover of pseudorabies virus variants to humans: an urgent call for pseudorabies eradication in domestic pigs.
The Lancet. MicrobePost-mortem characterisation of HIV-associated under-5 deaths in the CHAMPS network: population-based mortality surveillance.
The lancet. HIVDurable protection against lethal Rift Valley fever hepatitis and encephalitis following low-dose ΔNSsΔNSm vaccination in mice.
mSphereTwo cases of estazolam poisoning presenting to an emergency department in Western Australia.
Clinical toxicology (Philadelphia, Pa.)Herpes simplex virus genomes from an under-sampled population in Namibia reveal novel genetic diversity.
medRxiv : the preprint server for health sciencesInnate immune signalling, neuroinflammation and network plasticity in temporal lobe epilepsy.
Frontiers in pharmacologyAnti-IgLON5 encephalitis is associated with anti-retinal immunological reactivity without retinal alteration.
Journal of translational autoimmunityJapanese Encephalitis: Understanding Its Impact, Prevention, and the Role of Vaccination.
Reviews in medical virologyJamestown Canyon Virus Disease: An Analytic Review of Human Cases Reported from 1982 Through 2022.
Viruses1'- and 4'-Cyano Modified Adenosine Analogs Against Prototypic Flavivirus RNA-Dependent RNA Polymerases.
VirusesHuman Herpesvirus 6-Associated Miller-Fisher Syndrome in a 5-Year-Old Child: A Case-Based Narrative Review of Pediatric Cases with Infectious Triggers.
VirusesCombined Glycoprotein Mutations in Rabies Virus Promote Astrocyte Tropism and Protective CNS Immunity in Mice.
VirusesmRNA Vaccine Against Japanese Encephalitis Virus Genotype IV Protects Against Lethal Infection.
VirusesA Bovine Cell Line Resistant to Japanese Encephalitis Virus Entry but Permissive to Post-Entry Replication.
VirusesFrom Respiratory Pathogen to Systemic Threat: Rethinking Mycoplasma pneumoniae Infections.
MicroorganismsExperience of a Romanian Lyme Borreliosis Centre in the Multidisciplinary Management of Patients Evaluated for Suspected Lyme Neuroborreliosis.
MicroorganismsDivergent Inflammatory Profiles but No Predictive Biomarkers of Psychiatric Sequelae After Viral Infection: A 12-Month Cohort Study.
International journal of molecular sciencesRegion-Specific NRF2 Signaling in HIV-Associated Neurocognitive Disorders: A Transcriptomic and Computational Histology Study.
GenesCAR T-Cell Immunotherapy in Neuroautoimmune Diseases: Focus on the Central Nervous System.
BiomedicinesIntegrating Syndromic Molecular Assays into Routine Diagnostic Microbiology: Benefits and Challenges.
Antibiotics (Basel, Switzerland)Clinical features and outcomes of anti-NMDAR autoimmune-related central nervous system involvement in patients with teratoma: a retrospective cohort study.
BMC neurologyPreoperative predictors of seizure freedom after hemispheric surgery for rasmussen's encephalitis: An individual participant data meta-analysis.
Neurosurgical reviewCocrystals of telmisartan with ascorbic acid: Enhanced solubility and antiviral potency against Japanese encephalitis virus.
Journal of pharmaceutical sciencesRare demyelinating diseases of the central nervous system: A diagnostic and therapeutic challenge - based on the case of a young woman with MOGAD.
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Fixel-Based Analysis of Pretreatment MRI Identifies White Matter Abnormalities in Pediatric Anti-NMDAR Encephalitis.
- [18F]Fluorodeprenyl-D2 PET as a Tool to Monitor Disease Activity in GAD65-Ab Autoimmune Encephalitis.
- Population-Based Epidemiology of Autoimmune Seizures and Epilepsies.
- Inactivated Japanese encephalitis virus vaccination imprints fusion loop-biased antibody responses that are attenuated by repeated live-attenuated dengue vaccination.
- Clinico-etiological profile and prognostic factors of acute febrile encephalopathy in children: a prospective study from Indian subcontinent.
- Anti-Glutamic Acid Decarboxylase 65 (Anti-GAD65) Autoimmune Encephalopathy: A Case of Diagnostic and Treatment Challenge.
- Evidence of West Nile virus exposure in healthy donors and a clinical case in an immunocompromised child: emerging public health implications.
- Intraventricular hemorrhage, suspected EBV reactivation, and TBA-positive epilepsy after deep cervical lymphovenous anastomosis in Alzheimer's disease: a case report.
- One health perspectives on the epidemiological features and changing incidence of natural focus and vector-borne infectious diseases in China: An observational trend study.
- Human antibodies against West Nile and related orthoflaviviruses.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:97275(Orphanet)
- MONDO:0019956(MONDO)
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
- Q199615(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
