Raras
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Displasia broncopulmonar
ORPHA:70589CID-10 · P27.1CID-11 · KB29.0DOENÇA RARA

A displasia broncopulmonar é uma doença respiratória crônica que surge de complicações relacionadas a danos nos pulmões durante o tratamento da síndrome do desconforto respiratório agudo infantil em bebês prematuros com baixo peso ao nascer, ou devido ao desenvolvimento anormal dos pulmões em bebês mais velhos. Os sinais que podem ser observados incluem respiração rápida, coração acelerado e sinais de dificuldade respiratória, como o afundamento entre as costelas, gemidos ao respirar e narinas que se alargam.

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Introdução

O que você precisa saber de cara

📋

A displasia broncopulmonar é uma doença respiratória crônica que surge de complicações relacionadas a danos nos pulmões durante o tratamento da síndrome do desconforto respiratório agudo infantil em bebês prematuros com baixo peso ao nascer, ou devido ao desenvolvimento anormal dos pulmões em bebês mais velhos. Os sinais que podem ser observados incluem respiração rápida, coração acelerado e sinais de dificuldade respiratória, como o afundamento entre as costelas, gemidos ao respirar e narinas que se alargam.

Pesquisas ativas
30 ensaios
356 total registrados no ClinicalTrials.gov
Publicações científicas
11.127 artigos
Último publicado: 2026 Apr 17
Medicamentos
11 registrados
BECLOMETHASONE DIPROPIONATE, NITRIC OXIDE, DEXAMETHASONE

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11 medicamentos registrados
Ver detalhes, fases e interações →
BECLOMETHASONE DIPROPIONATENITRIC OXIDEDEXAMETHASONEMETHYLPREDNISOLONECAFFEINEBUDESONIDEHYDROCORTISONEIBUPROFENSILDENAFILFUROSEMIDE

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
1-5 / 10 000
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
13.0
Europe
Início
Infancy
+ neonatal
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: P27.1
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Entender a doença

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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🫁
Pulmão
14 sintomas
❤️
Coração
3 sintomas

+ 10 sintomas em outras categorias

Características mais comuns

90%prev.
Hiperoxemia
Muito frequente (99-80%)
90%prev.
Tosse
Muito frequente (99-80%)
90%prev.
Insuficiência respiratória necessitando de ventilação assistida
Muito frequente (99-80%)
90%prev.
Enfisema
Muito frequente (99-80%)
90%prev.
Doença pulmonar crônica
Muito frequente (99-80%)
90%prev.
Dispneia
Muito frequente (99-80%)
27sintomas
Muito frequente (10)
Frequente (12)
Ocasional (5)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 27 características clínicas mais associadas, ordenadas por frequência.

HiperoxemiaHyperoxemia
Muito frequente (99-80%)90%
TosseCough
Muito frequente (99-80%)90%
Insuficiência respiratória necessitando de ventilação assistidaRespiratory failure requiring assisted ventilation
Muito frequente (99-80%)90%
EnfisemaEmphysema
Muito frequente (99-80%)90%
Doença pulmonar crônicaChronic lung disease
Muito frequente (99-80%)90%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico11.127PubMed
Últimos 10 anos200publicações
Pico2026167 papers
Linha do tempo
2026Hoje · 2026🧪 1984Primeiro ensaio clínico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
3Fase 39
2Fase 27
1Fase 12
·Pré-clínico12
Medicamentos catalogadosEnsaios clínicos· 10 medicamentos · 20 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Displasia broncopulmonar

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

15 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

Outros ensaios clínicos

356 ensaios clínicos encontrados, 30 ativos.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
6.652 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 6.652

#1

Modulation of Alveolar Macrophages by Sex as a Biological Variable.

American journal of physiology. Lung cellular and molecular physiology2026 Mar 24

Este estudo revela que as células imunes dos pulmões (macrófagos) de recém-nascidos respondem de forma diferente ao estresse por oxigênio – um fator comum na Displasia Broncopulmonar (DBP) – dependendo do sexo biológico. Notavelmente, os macrófagos pulmonares de neonatos masculinos mostram um impacto mais significativo na sua função energética (mitocondrial) sob alta concentração de oxigênio em comparação com os femininos, que demonstram maior resiliência metabólica. Isso sugere que a susceptibilidade à DBP pode variar entre meninos e meninas devido a essas diferenças biológicas intrínsecas, indicando a necessidade futura de estratégias de tratamento personalizadas para cada sexo.

🇧🇷 traduzido
#2

What is the role of diuretics in the prevention and management of bronchopulmonary dysplasia?

Current treatment options in pediatrics2026 Dec

Este artigo analisa o papel dos diuréticos na prevenção e manejo da displasia broncopulmonar (DBP), concluindo que seu benefício é incerto. Apesar do uso comum, a maioria das evidências é antiga ou não demonstra benefícios claros na prevenção da DBP ou na redução da mortalidade, embora possa haver melhorias transitórias na função respiratória. Portanto, sugere-se que médicos minimizem o uso rotineiro e considerem tratamentos seletivos de curto prazo com objetivos claros, devido à falta de provas robustas.

🇧🇷 traduzido
#3

Impact of a Structured Brain Care Bundle on Severe Germinal Matrix Hemorrhage-Intraventricular Hemorrhage in Very Preterm Neonates: A Retrospective Cohort Study.

Pediatric neurology2026 Feb 23

Este estudo avaliou a implementação de um "Pacote de Cuidados Cerebrais" (BCBs) em recém-nascidos muito prematuros, focando na prevenção de problemas neurológicos. Ele demonstrou uma redução significativa na hemorragia intraventricular grave (sangramentos cerebrais) e na sepse de início tardio. No entanto, para pacientes e médicos preocupados com a displasia broncopulmonar (DPB), o estudo não encontrou diferenças significativas nas taxas de DPB após a implementação deste pacote de cuidados. Isso sugere que, embora o BCBs seja benéfico para o cérebro e para reduzir infecções, não impacta diretamente a incidência de DPB.

🇧🇷 traduzido
#4

Rebalancing the Neurovascular Axis: NTRK2 Isoform Equilibrium as a Determinant of Pulmonary Endothelial Regeneration.

Cell proliferation2026 Mar 19

Uma nova pesquisa identifica que o equilíbrio entre as diferentes formas de uma proteína específica (NTRK2) desempenha um papel fundamental na regeneração dos vasos sanguíneos e alvéolos pulmonares, cruciais na Displasia Broncopulmonar (DBP). Para pacientes e médicos, isso significa que entender e, potencialmente, modular esse equilíbrio pode abrir caminhos para novas estratégias de tratamento, visando promover uma melhor cicatrização e desenvolvimento pulmonar em bebês prematuros afetados pela DBP.

🇧🇷 traduzido
#5

Flavin adenine dinucleotide increases antioxidant availability and protects neonatal C57Bl6 lungs from high oxygen induced lung injury.

American journal of physiology. Cell physiology2026 Mar 11

Este estudo investiga o potencial do Flavin Adenine Dinucleotide (FAD) como uma nova terapia para a displasia broncopulmonar (DBP), uma condição grave em recém-nascidos prematuros decorrente de lesão pulmonar induzida por alta concentração de oxigênio. Em modelos pré-clínicos, a administração intranasal de FAD demonstrou proteger os pulmões neonatais ao aumentar a disponibilidade de antioxidantes, reduzir o estresse oxidativo e a inflamação, e diminuir significativamente os escores de lesão pulmonar. Esses achados sugerem que o FAD pode ser uma estratégia promissora para modular a inflamação e proteger os pulmões de recém-nascidos da DBP.

🇧🇷 traduzido

Publicações recentes

Ver todas no PubMed

📚 EuropePMC4.490 artigos no totalmostrando 196

2026

Modulation of Alveolar Macrophages by Sex as a Biological Variable.

American journal of physiology. Lung cellular and molecular physiology
2026

What is the role of diuretics in the prevention and management of bronchopulmonary dysplasia?

Current treatment options in pediatrics
2026

Maternal hypertension and survival without bronchopulmonary dysplasia in preterm infants: a meta-analysis of cohort studies.

The journal of maternal-fetal &amp; neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
2026

Coordinating Tracheostomy and Gastrostomy in Infants with Bronchopulmonary Dysplasia.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
2026

Letter regarding Pini, A., Nardini, P., Zizi, V., Molino, M., Calvani, M., Carrozzo, F., … Filippi, L. (2026). β3-adrenoceptor agonism exerts lung protection in a rat model of bronchopulmonary dysplasia. Br J Pharmacol, in press.

British journal of pharmacology
2026

Patent Ductus Arteriosus Persistence and Neurodevelopmental Outcomes: A Restrictive Treatment Approach Does Not Compromise Neurological Development.

Acta paediatrica (Oslo, Norway : 1992)
2026

Trends in Survival and Short-Term Outcomes Among Preterm Infants Less Than 32 Weeks From 2016 to 2022: A Retrospective Cohort Study at a Tertiary Medical Center in the UAE.

Cureus
2026

Longitudinal data analysis of lung aeration and gas exchange trajectories in bronchopulmonary dysplasia: the devil is in the details-authors' reply.

The Lancet regional health. Europe
2026

Impact of a Structured Brain Care Bundle on Severe Germinal Matrix Hemorrhage-Intraventricular Hemorrhage in Very Preterm Neonates: A Retrospective Cohort Study.

Pediatric neurology
2026

Neonatal brain abnormalities predict preschool executive functioning performance in children born very preterm.

Developmental psychology
2026

Respiratory Outcomes in Infants and Children With Bronchopulmonary Dysplasia Living in Rural Areas.

Pediatric pulmonology
2026

Rebalancing the Neurovascular Axis: NTRK2 Isoform Equilibrium as a Determinant of Pulmonary Endothelial Regeneration.

Cell proliferation
2026

Elevated Driving Pressure in Pressure-Controlled Ventilation: An Independent Risk Factor for Adverse Outcomes in Mechanically Ventilated Neonates.

Lung
2025

[Low levels of vitamin D at one month of age and its association with bronchopulmonary dysplasia in premature newborns under 32 weeks and/or under 1500 g].

Andes pediatrica : revista Chilena de pediatria
2026

Development of an interdisciplinary tool to assess severe BPD phase of illness and application evaluating impact of tracheostomy.

Journal of perinatology : official journal of the California Perinatal Association
2026

Offering a Potential Route to Better Neonatal ICU to PICU Transitions.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2026

Extracellular vesicle-mediated transcellular mitophagy as a modulatory target for moderate hyperoxia-induced alveolar developmental arrest in bronchopulmonary dysplasia.

Free radical biology &amp; medicine
2026

Relationships between lung ultrasound, chest CT, and echocardiographic findings in children with bronchopulmonary dysplasia: A multimodal imaging study.

Respiratory medicine
2026

Use of Aflibercept to Treat Retinopathy of Prematurity in Children with Extremely Low Birth Weight.

Journal of clinical medicine
2026

Trajectory of lung ultrasound scores in preterm infants at risk for bronchopulmonary dysplasia.

Journal of perinatology : official journal of the California Perinatal Association
2026

Association between risk-adjusted mortality and severe morbidity in very low birth weight infants: a multicenter study from the NEOCOSUR network.

Journal of perinatology : official journal of the California Perinatal Association
2026

The impact of Assisted Reproductive Technology on the neonatal prognosis of newborns < 29 weeks gestational age: a retrospective case-control study.

Journal of gynecology obstetrics and human reproduction
2026

Examining the role of biologic sex on kidney outcomes in preterm neonates: A secondary analysis of the PENUT/REPAIReD study.

Pediatric nephrology (Berlin, Germany)
2026

BPD-Neo: An MRI Dataset for Lung-Trachea Segmentation with Clinical Data for Neonatal Bronchopulmonary Dysplasia.

Scientific data
2026

Omics approaches to bronchopulmonary dysplasia: a first step in the right direction?

Thorax
2026

Flavin adenine dinucleotide increases antioxidant availability and protects neonatal C57Bl6 lungs from high oxygen induced lung injury.

American journal of physiology. Cell physiology
2026

The Value of Cord Blood CXCL10 and MMP8 as Biomarkers in Predicting Bronchopulmonary Dysplasia- A Retrospective Cohort Study.

International journal of general medicine
2026

Mitochondria-derived peptide MOTS-c alleviates hyperoxia-induced bronchopulmonary dysplasia in neonatal mice by activating Nrf2 pathway.

European journal of pharmacology
2026

European Consensus Guidelines on the Management of Respiratory Distress Syndrome - 2025.

Neonatology
2026

High-Frequency Oscillation vs Mechanical Ventilation for Neonatal Acute Respiratory Distress Syndrome: A Randomized Clinical Trial.

JAMA network open
2026

Prevalence, perinatal risk factors and clinical outcomes of respiratory Ureaplasma species colonization in hospitalized preterm infants.

Frontiers in pediatrics
2026

ECMO use in infants with bronchopulmonary dysplasia: a literature review.

Journal of perinatology : official journal of the California Perinatal Association
2026

Beyond bronchopulmonary dysplasia: impact of human milk feeding on long-term respiratory morbidity in very preterm infants.

European journal of pediatrics
2026

Randomised al.Phase 2b trial of rhIGF-1/rhIGFBP-3 (OHB-607) for bronchopulmonary dysplasia prevention in preterm neonates: study protocol.

BMJ paediatrics open
2026

Inhibition of mitochondrial integrated stress response ameliorates ibuprofen-induced endothelial dysfunction in neonatal hyperoxia-induced lung injury.

Biochemical pharmacology
2026

Drying Very Preterm Infants Before Plastic Wrapping at Birth: A Randomized Clinical Trial.

JAMA network open
2026

A Narrative Review of Gene-Environment Interactions in Pediatric Pulmonology.

Pediatric pulmonology
2026

Impact of timing from last dose of dexamethasone administration to delivery, different steroid courses, and fetal number on preterm neonatal outcomes.

PloS one
2026

[A real-world study on the association between treatment of patent ductus arteriosus in extremely preterm infants and the risk of bronchopulmonary dysplasia].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
2026

Neonatal Hyperoxia Induces Metabolic Reprogramming in Senescent Alveolar Macrophages, Leading to Persistent Lung Injury.

Frontiers in bioscience (Landmark edition)
2026

Decrease in intestinal microbiome diversity at birth is related to moderate and severe bronchopulmonary dysplasia in premature infants.

Pediatrics and neonatology
2026

Early lung ultrasound score combined with umbilical cord-blood procalcitonin improves 1-year prognostic stratification in preterm neonates with respiratory distress syndrome.

Frontiers in pediatrics
2026

Electrical Activity of the Diaphragm (Edi) Metrics in Premature Infants Receiving Invasive Mechanical Ventilation Versus Noninvasive Respiratory Support.

Cureus
2026

Tailoring Therapy to Bronchopulmonary Dysplasia Phenotype: A Ten-Year Experience in Precision Medicine.

Children (Basel, Switzerland)
2026

Physiology-Based Diagnosis and Management of Bronchopulmonary Dysplasia Associated Pulmonary Hypertension (BPD-PH).

Children (Basel, Switzerland)
2026

Pulse Oximetry Histogram Profiles Before and After Red Blood Cell Transfusion in Very Preterm Infants: A Prospective Observational Cohort.

Children (Basel, Switzerland)
2026

Novel translational pulmonary MRI in pediatrics: A Review of the last 10 years.

The European respiratory journal
2026

NEC-Associated Bronchopulmonary Dysplasia and the Gut-Lung Axis in Preterm Infants.

American journal of perinatology
2026

Early predictors of cognitive trajectories from birth to adolescence in children born extremely preterm.

Developmental medicine and child neurology
2026

Plasma Extracellular Vesicles from Bronchopulmonary Dysplasia Infants Initiate Inflammation and Abnormal Angiogenesis in Neonatal Murine Retinas.

Cells
2026

Label-free optical fingerprints of hyperoxia-induced lung alterations in preterm rabbits.

Respiratory research
2026

Titrating cumulative neonatal hyperoxia in mice to model bronchopulmonary dysplasia severities.

American journal of respiratory cell and molecular biology
2026

CD44 is critical for TLR4-mediated NLRP3 inflammasome activation and the development of BPD.

American journal of respiratory cell and molecular biology
2026

Pulmonary Vascular Growth in Bronchopulmonary Dysplasia Using Magnetic Resonance Imaging.

American journal of respiratory and critical care medicine
2026

Impaired Taurine Transport Contributes to Bronchopulmonary Dysplasia: A Systems Biology Analysis.

American journal of respiratory cell and molecular biology
2026

IGF1/IGFBP3 as a therapy to decrease the incidence and severity of Bronchopulmonary Dysplasia: A journey from basic science to bedside and back.

American journal of respiratory and critical care medicine
2026

Recombinant human IGF-1 complex preserves lung development in mechanically ventilated preterm lambs.

American journal of respiratory and critical care medicine
2026

Early prediction of bronchopulmonary dysplasia using new classification in high-risk preterm infants.

Clinical and experimental pediatrics
2026

Electrical impedance tomography reveals ventilation and perfusion heterogeneity in infants with bronchopulmonary dysplasia.

Journal of perinatology : official journal of the California Perinatal Association
2026

Effects of higher caffeine dosing on rates of bronchopulmonary dysplasia and neurodevelopmental outcomes.

Journal of perinatology : official journal of the California Perinatal Association
2026

Dexmedetomidine and midazolam usage and association with BSRI scores in preterm infants with chronic respiratory failure.

Journal of perinatology : official journal of the California Perinatal Association
2026

Clinical utility of echocardiography in bronchopulmonary dysplasia: a retrospective cohort study.

Jornal de pediatria
2026

In-Hospital Outcomes of Very Preterm and Very Low Birth Weight Neonates: A Multicenter Retrospective Study from India.

Indian pediatrics
2026

Angiogenic factors and fetal Doppler for predicting adverse pregnancy outcome in early-onset small fetuses with and without pre-eclampsia.

Ultrasound in obstetrics &amp; gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
2026

Outcomes of children after initiation of home mechanical ventilation via tracheostomy: a single center retrospective study.

BMC pulmonary medicine
2026

KD-SqueezeNet: an efficient deep learning strategy for the multi-task diagnosis of neonatal lung diseases.

Pediatric radiology
2026

Do different lipid emulsions affect brain development? A single-center retrospective analysis.

Frontiers in nutrition
2026

Pharmacokinetics, safety and preliminary efficacy study of montelukast in critically ill infants with developing bronchopulmonary dysplasia (PRISM).

Contemporary clinical trials communications
2026

Early Prophylactic Hydrocortisone and Bronchopulmonary Dysplasia-Free Survival in Extremely Preterm Infants.

JAMA network open
2026

Peri and Neonatal Risk Factors and Structural Lung Abnormalities Predict Hypoxic Challenge Test Failure in Infants With Severe Bronchopulmonary Dysplasia.

Pediatric pulmonology
2026

Outcomes and complications of invasive versus non-invasive respiratory support in extremely preterm infants: a retrospective study.

BMC pediatrics
2026

An automated morphometric approach to evaluate distal lung patterning in mouse models of bronchopulmonary dysplasia.

PloS one
2026

Predicting pulmonary hypertension in infants with bronchopulmonary dysplasia.

Journal of perinatology : official journal of the California Perinatal Association
2026

Results of a pulmonary hypertension screening program for premature infants with bronchopulmonary dysplasia.

Journal of perinatology : official journal of the California Perinatal Association
2026

A non-invasive diagnostic tool for the assessment of optimal positive-end expiratory pressure (PEEPOPT) in infants receiving prolonged invasive ventilation.

Journal of perinatology : official journal of the California Perinatal Association
2026

PKM2 Promotes Glycolysis in Alveolar Macrophages and Induces Inflammation in Bronchopulmonary Dysplasia.

Inflammation
2026

Common Biomarkers in Chronic Obstructive Pulmonary Disease and Bronchopulmonary Dysplasia: A Narrative Review of an Intriguing Interplay.

International journal of molecular sciences
2026

FOXF2 regulates pericyte-endothelial signaling required for vascular homeostasis after neonatal hyperoxic lung injury.

Nature communications
2026

Automatic versus manual control of oxygen and neonatal clinical outcomes in extremely preterm infants: a multicentre, parallel-group, randomised, controlled, superiority trial.

The Lancet. Child &amp; adolescent health
2026

Trends and Contributing Factors Affecting Survival and Neurodevelopmental Outcomes in Infants Born at ≤25 Weeks' Gestation: A Retrospective Single-Center Study.

American journal of perinatology
2026

Early Maturation of Heart Rate Variability in Very Preterm Infants Depends on Neonatal Factors and Is Associated With Neurodevelopmental Risk.

Acta paediatrica (Oslo, Norway : 1992)
2026

Differential Trajectories of Airway and Parenchymal Function in Infants Born Preterm.

The Journal of pediatrics
2026

Stress exposure, stress responses, and short-term outcomes in very preterm neonates: a national cohort study.

European journal of pediatrics
2025

Elective HFOV vs CMV as Early Intervention: A Clinical Trial in Neonates with Acute Respiratory Distress Syndrome.

Advanced biomedical research
2026

Disease Spectrum of Human Metapneumovirus Infections in Infants and Young Children: Data From a Prospective Multicenter Study in Germany.

The Pediatric infectious disease journal
2026

The association between bronchopulmonary dysplasia severity and neurodevelopmental disorders.

Journal of perinatology : official journal of the California Perinatal Association
2026

Neighborhood Opportunity and Early Life Indicators of Respiratory Health in Children Born Very Preterm.

Pediatric pulmonology
2026

Outcome after Selective early treatment for Closure of patent ductus ARteriosus in preterm babies, a multicentre, masked, randomised placebo-controlled parallel group trial (Baby-OSCAR trial).

Health technology assessment (Winchester, England)
2026

Macrolides for the prevention of bronchopulmonary dysplasia in preterm neonates.

The Cochrane database of systematic reviews
2025

Perinatal outcomes in neonates referred to social services in a tertiary neonatal intensive care unit from a resource-limited setting: a five-year study.

Frontiers in pediatrics
2026

The Effectiveness of Respiratory Syncytial Virus Prophylaxis Programme using Palivizumab in Preterm Infants: A single institute retrospective study.

Sultan Qaboos University medical journal
2026

Exercise Capacity and Ventilatory Response in Children Who Were Born Preterm, With and Without Bronchopulmonary Dysplasia.

Pediatric pulmonology
2026

Beyond the Echocardiogram: Cardiac Catheterization in Infants with Bronchopulmonary Dysplasia Associated Pulmonary Hypertension.

The Journal of pediatrics
2026

Indole-3-Propionic Acid Improves Alveolar Development Impairment via Targeting VAMP8-mediated SNAREs Complex Formation in Bronchopulmonary Dysplasia.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
2026

Apgar Score Plus Umbilical Artery pH and Adverse Neonatal Outcomes in Very Preterm Infants.

JAMA network open
2026

Gut microbiota and metabolomic changes across preterm stages: potential associations with bronchopulmonary dysplasia.

Microbiology spectrum
2026

Variable clinical and hemodynamic effect of sildenafil in extreme premature infants with bronchopulmonary dysplasia-associated pulmonary hypertension.

Journal of perinatology : official journal of the California Perinatal Association
2026

From Pathway to Practice: Implementing Evidence-Based Quality Improvement for ELBW Care.

American journal of perinatology
2026

Diagnostic potential of serum miR-197 and IL-18 levels in predicting bronchopulmonary dysplasia: a prospective cohort study.

BMC pediatrics
2026

Reversible Airway Obstruction on Impulse Oscillometry in Preschool Children with Bronchopulmonary Dysplasia.

The Journal of pediatrics
2026

Early-onset preeclampsia: gestational age threshold of potential benefits.

European journal of obstetrics, gynecology, and reproductive biology
2026

IFN-γ and TNF-α Impair Lung Development by Upregulating SMAD7 to Inhibit TGF-β Signaling Pathway and ECM Dysregulation.

Inflammation
2026

Co-occurrence network analysis reveals novel associations between the neonatal airway microbiome and bronchopulmonary dysplasia risk: an observational, population-based study.

mSphere
2026

Breathe Easier: Optimizing Continuous Positive Airway Pressure in the Neonatal Intensive Care Unit.

Advances in neonatal care : official journal of the National Association of Neonatal Nurses
2026

Patient-derived lung organoids from bronchoalveolar lavage capture epithelial heterogeneity and disease biology in bronchopulmonary dysplasia.

Redox biology
2026

Sodium propionate alleviates bronchopulmonary dysplasia by inhibiting ferroptosis through the SLC7A11/GPX4 pathway in pulmonary endothelial cells.

Respiratory research
2026

Survival without bronchopulmonary dysplasia in extremely preterm infants: an external, population-based validation, comparison and optimisation study of recent prediction models at baseline.

Archives of disease in childhood. Fetal and neonatal edition
2026

Perinatal and Maternal Outcomes by Indication for Delivery in the Second Trimester.

American journal of perinatology
2026

Desaturations with or without Bradycardia Are Associated with Cerebral and Abdominal Hypoxemia: Secondary Analysis of a Randomized Clinical Trial.

Neonatology
2025

Analysis of the Role of Gene Variants in Matrix Metalloproteinases and Their Tissue Inhibitors in Bronchopulmonary Dysplasia (BPD): A Study in the Polish Population.

Current issues in molecular biology
2025

Dietary and complementary oral supplements for the management of chronic diseases in children: a systematic review.

Frontiers in pediatrics
2025

Prevalence and early-life risk factors of asthma in preterm adolescents: a cohort study.

Frontiers in pediatrics
2026

Immune profiles and growth outcomes in very and extremely preterm infants with bronchopulmonary dysplasia: A prospective cohort study.

Pediatrics and neonatology
2026

Endothelial MLKL Inhibition Reduces Hyperoxia-Induced Bronchopulmonary Dysplasia in Neonatal Mice.

Journal of cellular and molecular medicine
2026

Variations in bronchopulmonary dysplasia prevalence and outcomes by definition: a multicentre cohort study from the Chinese Neonatal Network.

BMJ open
2025

Postnatal Cytomegalovirus Infection in a Neonatal Intensive Care Unit: A Retrospective Study.

Cureus
2026

Lung Ultrasound in Bronchopulmonary Dysplasia: A Comparative Diagnostic Study With CT, Chest x-Ray and Pulmonary Function Tests.

Journal of paediatrics and child health
2026

Risk Factors for Postnatal Growth Faltering and Undernutrition at Discharge in Very Preterm Infants: A Retrospective Study Applying the ESPGHAN Consensus Definitions.

Nutrients
2026

The Impact of Enteral Nutrition Type, Volume, and Time of Introduction on the Risk of Growth Failure and Bronchopulmonary Dysplasia in Preterm Infants.

Nutrients
2026

Endotracheal Intubation in Early Life and Its Association with Mental Health Disorders from Childhood to Adolescence: A National Longitudinal Cohort Study up to Age 18.

Journal of clinical medicine
2026

Non-Invasive Surfactant Administration in Preterm Infants.

Children (Basel, Switzerland)
2025

Respiratory Sequelae of Prematurity in School-Age Children: Is Bronchopulmonary Dysplasia Still the Primary Risk Factor?

Children (Basel, Switzerland)
2025

Association of Bach1 Gene Polymorphisms with Susceptibility to Bronchopulmonary Dysplasia in Preterm Infants.

Biomedicines
2025

Pharmacologic Inhibition of S-Nitrosoglutathione Reductase Prevents Hyperoxic Alveolar and Airway Disease in Newborn Mice.

Biomedicines
2026

BPD prediction model for very preterm infants integrating chest X-ray scores within 7 days: a retrospective case-control study.

BMJ open
2026

Establishment of a rat model of bronchopulmonary dysplasia complicated with pulmonary hypertension and its potential applications.

Human &amp; experimental toxicology
2026

Identifying the risk factors of autism spectrum disorders in infants born preterm: a systematic review and meta-analysis.

European child &amp; adolescent psychiatry
2025

Complications of Interventional Versus Surgical Closure of Patent Ductus Arteriosus in Very Preterm Infants-A Retrospective Analysis.

Journal of cardiovascular development and disease
2026

Postnatal corticosteroids and bronchopulmonary dysplasia: balancing pulmonary and neurologic effects to enable individualized decision-making.

Current opinion in pediatrics
2026

Transfusion of blood products and neonatal outcomes in preterm infants: A retrospective cohort study.

Transfusion
2026

The Effect of Vitamin A and Retinol-Binding Protein Levels in Cord Blood of Very Low Birth Weight Infants on Mortality and Morbidity.

Klinische Padiatrie
2025

Maternal inflammatory biomarkers and neonatal characteristics as predictors of bronchopulmonary dysplasia in preterm infants: a retrospective cohort study.

Frontiers in medicine
2026

Low hyper-oxygen exposure induces p21-dependent p53-independent senescence in alveolar cells.

International journal of medical sciences
2026

Dexmedetomidine attenuates hyperoxia-induced lung injury in BPD mice via regulation of the mitophagy-NLRP3-pyroptosis pathway.

Archives of biochemistry and biophysics
2026

β3-adrenoceptor agonism exerts lung protection in a rat model of bronchopulmonary dysplasia.

British journal of pharmacology
2026

Respiratory Practices to Prevent or Treat Evolving Bronchopulmonary Dysplasia: A European Survey.

The Journal of pediatrics
2026

Therapeutic potential and translational challenges of extracellular vesicles in neonatal medicine.

Bioengineering &amp; translational medicine
2026

High-flow nasal cannula versus CPAP for the prevention of bronchopulmonary dysplasia in preterm infants: a systematic review with meta-analysis and trial sequential analysis.

Respiratory medicine
2026

Deep Learning-Based Prediction of Cardiopulmonary Disease in Retinal Images of Premature Infants.

JAMA ophthalmology
2026

Utilization of integrated lung ultrasound and targeted neonatal echocardiography in preterm infant follow-up: is it feasible? Assessing value and practical challenges.

European journal of pediatrics
2026

Patent ductus arteriosus: emerging trial evidence firmly supports conservative management in preterm infants.

Current opinion in pediatrics
2025

Study protocol for the volume targeted mask ventilation versus pressure ventilation in preterm infants-the VOLT-trial.

Frontiers in pediatrics
2026

Lung aeration and gas exchange in preterm infants developing moderate-to-severe bronchopulmonary dysplasia: a multicentre prospective study from the PATH-BPD cohort.

The Lancet regional health. Europe
2026

Validation of a new Japanese classification for predicting severe bronchopulmonary dysplasia in preterm infants.

Clinical and experimental pediatrics
2026

Impact of Nonhemodynamically Significant Patent Ductus Arteriosus on Pulmonary Function in Premature Neonates.

The Journal of pediatrics
2026

Time-Series Machine Learning for Prediction of Bronchopulmonary Dysplasia.

The Journal of pediatrics
2026

Quantitative assessment of neonatal health using dried blood spot metabolite profiles and deep learning.

Science translational medicine
2026

Successful perinatal management of a large placental chorio-angioma: a case report demonstrating the effectiveness of a public-private partnership model.

Paediatrics and international child health
2026

Machine learning integrated extracellular vesicle proteome analysis for early markers of bronchopulmonary dysplasia.

Function (Oxford, England)
2025

Development and validation of a nomogram to predict bronchopulmonary dysplasia in very preterm, very low birth weight infants.

American journal of translational research
2025

Overview of extracellular vesicles as biomarkers and therapeutic tools in pediatric diseases: focus on the gut-lung axis.

Extracellular vesicles and circulating nucleic acids
2026

Fetal hemoglobin fraction is correlated to the risk of prematurity complications.

The journal of maternal-fetal &amp; neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
2026

Hemodynamically significant PDA impacts adverse outcomes in infants with BPD: a multicenter study.

Pediatric research
2026

Stratified Comparison of Risk Factors for Mild Versus Moderate-to-Severe Bronchopulmonary Dysplasia in Very Preterm Infants (< 32 Weeks Gestational Age).

Lung
2026

Inhibition of Rho-kinase restores impaired relaxation of airway smooth muscle in rat pups exposed to neonatal hyperoxia.

Physiological reports
2026

Association of birth weight Z-score with bronchopulmonary dysplasia or mortality in very preterm infants: a cohort study.

BMJ open respiratory research
2026

Impact of early parenteral amino acid on preterm infant: A multicenter study.

Pediatrics and neonatology
2026

Evidence-based early-post natal approaches to limiting pulmonary disease in extremely low birth weight infants.

Current opinion in pediatrics
2026

Developmental dynamics of bronchioalveolar stem cells revealed by dual-reporter lineage tracing.

Respiratory research
2026

Associations of Community Material Neighborhood Deprivation With the Diagnosis of Asthma Among Infants With Bronchopulmonary Dysplasia (BPD).

Pediatric pulmonology
2026

An Interventional Study on the Late Treatment of Severe Bronchopulmonary Dysplasia in Preterm Infants Using Mesenchymal Stromal Cells.

Stem cells international
2026

The Use of Treprostinil for Bronchopulmonary Dysplasia Associated Pulmonary Hypertension.

Pediatric pulmonology
2025

Lung trajectories into adulthood of preterm born survivors and the influence of sex.

Paediatric respiratory reviews
2026

Respiratory Physiotherapy in Preterm Neonates with Bronchopulmonary Dysplasia or Respiratory Distress Syndrome: A Comprehensive Review of Clinical Evidence and Therapeutic Implications.

Journal of clinical medicine
2026

Two isoforms, two outcomes: How NTRK2 shapes vascular regeneration.

Cell stem cell
2025

3-Mercaptopyruvate Sulfurtransferase (MPST) Regulates Mitochondrial Metabolism and Epithelial Differentiation in Neonatal Patient-derived Airway Cells.

bioRxiv : the preprint server for biology
2026

Lung ultrasound features during the evolution of BPD: a study from an animal model.

The journal of maternal-fetal &amp; neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
2025

The characteristics of pulmonary fibrosis in a neonatal rat model of chronic hyperoxia lung injury.

Translational pediatrics
2026

Follow-up of neonatal chronic respiratory disease: an update based on the current evidence.

European journal of pediatrics
2026

Unilateral absence of pulmonary artery presenting with pulmonary hypertension in two adults.

BMJ case reports
2026

Hospitalization Outcomes of Full-Term and Premature Children Aged Less Than 2 Years Hospitalized With RSV.

Pediatrics
2026

General movements and neurodevelopmental outcomes at 2 years of age in infants born very preterm.

Developmental medicine and child neurology
2026

Toward precision for bronchopulmonary dysplasia: Moving past current definitions.

Journal of perinatology : official journal of the California Perinatal Association
2025

The relationship of p50 with clinical outcomes in ventilated preterm infants.

Frontiers in pediatrics
2025

The utility of caffeine citrate as a neuroprotectant in the early life of premature newborns: a literature review of the effects on neurodevelopmental outcomes.

Frontiers in pediatrics
2026

Subglottic cysts as an uncommon cause of upper airway obstruction: a 12-year retrospective study.

Therapeutic advances in respiratory disease
2026

Is small for gestational age associated with reduced oxygen saturation to FiO2 ratio at 36 weeks postmenstrual age in preterm infants, independent of bronchopulmonary dysplasia? A retrospective Italian two-center cohort study.

European journal of pediatrics
2026

In-hospital and 12-24-month neurodevelopmental outcomes in periviable infants across two epochs: a cohort study from a tertiary neonatal unit in India.

Journal of tropical pediatrics
2026

Effectiveness and feasibility of orogastric tube for surfactant delivery in moderate or very preterm neonates with respiratory distress syndrome: an open-label randomized controlled trial.

Journal of tropical pediatrics
2025

Diagnostic accuracy of lung ultrasound score for bronchopulmonary dysplasia in preterm neonates: a systematic review and meta-analysis.

Frontiers in pediatrics
2025

Clinical characteristics and risk factors of severe bocavirus-positive pneumonia in children and a literature review.

Pediatric discovery
2026

Improving Platelet Transfusion Practice.

NeoReviews
2025

Unraveling the mechanism of alleviating hyperoxia-induced Bronchopulmonary dysplasia: miR-93-5p-mediated regulation of TNFRSF21.

Pediatrics and neonatology
2025

Neonatologist-Performed Echocardiography in Neonatal Pulmonary Hypertension: A Narrative Review of the Literature.

Diagnostics (Basel, Switzerland)
2025

Caffeine Protects Against Hyperoxia-Induced Structural Lung Injury and Restores Alveolar Development in Neonatal Rats.

Antioxidants (Basel, Switzerland)
2025

Oxidant Stress, Hyperoxia/Hypoxia and Neonatal Respiratory Disorders.

Antioxidants (Basel, Switzerland)
2025

Analysis of the Correlation Between Serum Procalcitonin (PCT), C-Reactive Protein (CRP) Levels and the Occurrence/Severity of Bronchopulmonary Dysplasia in ELBW/VLBW Neonates.

International journal of general medicine
2026

Too Few and Far Between: The Need for New Therapies to Treat Bronchopulmonary Dysplasia and the Potential of TFF3.

Pediatric pulmonology
2025

Mitochondrial quality control mechanisms as molecular targets for impaired lung development: from fetuses to neonates.

Respiratory research
2026

Rebalancing NTRK2 isoforms promotes vascular regeneration in bronchopulmonary dysplasia.

Cell stem cell
2026

Azithromycin for the eradication of respiratory tract Ureaplasma infection and prevention of bronchopulmonary dysplasia in preterm infants: what is the current evidence?

Archives of disease in childhood. Fetal and neonatal edition
2026

Outcomes in extremely preterm neonates after the introduction of early low-dose hydrocortisone treatment: A retrospective case-control study.

Early human development
2025

Early Biomedical and Environmental Factors Associated with Developmental Coordination Disorder in a Brazilian Preterm Cohort.

Brain sciences
2025

5-HT promotes bronchopulmonary dysplasia via TGM2-mediated serotonylation.

iScience
2025

Golden hour(s) quality improvement protocols and their effect on outcomes in preterm infants ≤ 32 weeks of gestation: a scoping review.

BMC pediatrics
2025

Determinants of volatile organic compound exposure among children with bronchopulmonary dysplasia.

Pediatric research
Ver todos os 4.490 no EuropePMC

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Modulation of Alveolar Macrophages by Sex as a Biological Variable.
    American journal of physiology. Lung cellular and molecular physiology· 2026· PMID 41874349mais citado
  2. What is the role of diuretics in the prevention and management of bronchopulmonary dysplasia?
    Current treatment options in pediatrics· 2026· PMID 41869072mais citado
  3. Impact of a Structured Brain Care Bundle on Severe Germinal Matrix Hemorrhage-Intraventricular Hemorrhage in Very Preterm Neonates: A Retrospective Cohort Study.
    Pediatric neurology· 2026· PMID 41855703mais citado
  4. Rebalancing the Neurovascular Axis: NTRK2 Isoform Equilibrium as a Determinant of Pulmonary Endothelial Regeneration.
    Cell proliferation· 2026· PMID 41852197mais citado
  5. Flavin adenine dinucleotide increases antioxidant availability and protects neonatal C57Bl6 lungs from high oxygen induced lung injury.
    American journal of physiology. Cell physiology· 2026· PMID 41811728mais citado
  6. NAVA use in infants with established bronchopulmonary dysplasia, congenital diaphragmatic hernia, and those on ECMO: a narrative literature review.
    J Perinatol· 2026· PMID 41991674recente
  7. Association between route of furosemide administration and diuretic response in very preterm infants with bronchopulmonary dysplasia.
    J Perinatol· 2026· PMID 41991672recente
  8. Pediatric Pulmonary Vein Stenosis and Treatment.
    Semin Roentgenol· 2025· PMID 41991351recente
  9. Non-invasive nitric oxide use for pulmonary hypertension and pulmonary vascular disease associated with bronchopulmonary dysplasia in preterm infants.
    J Perinatol· 2026· PMID 41986669recente
  10. Postnatal cytomegalovirus infection and bronchopulmonary dysplasia in very low birth weight infants: Influence of diagnostic criteria and viral load in a propensity score-matched cohort study.
    PLoS One· 2026· PMID 41984860recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:70589(Orphanet)
  2. MONDO:0019091(MONDO)
  3. GARD:5962(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Artigo Wikipedia(Wikipedia)
  6. Q922640(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Displasia broncopulmonar
Compêndio · Raras BR

Displasia broncopulmonar

ORPHA:70589 · MONDO:0019091
Prevalência
1-5 / 10 000
Herança
Not applicable
CID-10
P27.1 · Displasia broncopulmonar originada no período perinatal
CID-11
Ensaios
30 ativos
Medicamentos
11 registrados
Início
Infancy, Neonatal
Prevalência
13.0 (Europe)
MedGen
UMLS
C0006287
EuropePMC
Wikidata
Wikipedia
Papers 10a
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