A displasia broncopulmonar é uma doença respiratória crônica que surge de complicações relacionadas a danos nos pulmões durante o tratamento da síndrome do desconforto respiratório agudo infantil em bebês prematuros com baixo peso ao nascer, ou devido ao desenvolvimento anormal dos pulmões em bebês mais velhos. Os sinais que podem ser observados incluem respiração rápida, coração acelerado e sinais de dificuldade respiratória, como o afundamento entre as costelas, gemidos ao respirar e narinas que se alargam.
Introdução
O que você precisa saber de cara
A displasia broncopulmonar é uma doença respiratória crônica que surge de complicações relacionadas a danos nos pulmões durante o tratamento da síndrome do desconforto respiratório agudo infantil em bebês prematuros com baixo peso ao nascer, ou devido ao desenvolvimento anormal dos pulmões em bebês mais velhos. Os sinais que podem ser observados incluem respiração rápida, coração acelerado e sinais de dificuldade respiratória, como o afundamento entre as costelas, gemidos ao respirar e narinas que se alargam.
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
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Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 27 características clínicas mais associadas, ordenadas por frequência.
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Genética e causas
O que está alterado no DNA e como passa nas famílias
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Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
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Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Displasia broncopulmonar
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Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 6.652
Modulation of Alveolar Macrophages by Sex as a Biological Variable.
Este estudo revela que as células imunes dos pulmões (macrófagos) de recém-nascidos respondem de forma diferente ao estresse por oxigênio – um fator comum na Displasia Broncopulmonar (DBP) – dependendo do sexo biológico. Notavelmente, os macrófagos pulmonares de neonatos masculinos mostram um impacto mais significativo na sua função energética (mitocondrial) sob alta concentração de oxigênio em comparação com os femininos, que demonstram maior resiliência metabólica. Isso sugere que a susceptibilidade à DBP pode variar entre meninos e meninas devido a essas diferenças biológicas intrínsecas, indicando a necessidade futura de estratégias de tratamento personalizadas para cada sexo.
🇧🇷 traduzidoWhat is the role of diuretics in the prevention and management of bronchopulmonary dysplasia?
Este artigo analisa o papel dos diuréticos na prevenção e manejo da displasia broncopulmonar (DBP), concluindo que seu benefício é incerto. Apesar do uso comum, a maioria das evidências é antiga ou não demonstra benefícios claros na prevenção da DBP ou na redução da mortalidade, embora possa haver melhorias transitórias na função respiratória. Portanto, sugere-se que médicos minimizem o uso rotineiro e considerem tratamentos seletivos de curto prazo com objetivos claros, devido à falta de provas robustas.
🇧🇷 traduzidoImpact of a Structured Brain Care Bundle on Severe Germinal Matrix Hemorrhage-Intraventricular Hemorrhage in Very Preterm Neonates: A Retrospective Cohort Study.
Este estudo avaliou a implementação de um "Pacote de Cuidados Cerebrais" (BCBs) em recém-nascidos muito prematuros, focando na prevenção de problemas neurológicos. Ele demonstrou uma redução significativa na hemorragia intraventricular grave (sangramentos cerebrais) e na sepse de início tardio. No entanto, para pacientes e médicos preocupados com a displasia broncopulmonar (DPB), o estudo não encontrou diferenças significativas nas taxas de DPB após a implementação deste pacote de cuidados. Isso sugere que, embora o BCBs seja benéfico para o cérebro e para reduzir infecções, não impacta diretamente a incidência de DPB.
🇧🇷 traduzidoRebalancing the Neurovascular Axis: NTRK2 Isoform Equilibrium as a Determinant of Pulmonary Endothelial Regeneration.
Uma nova pesquisa identifica que o equilíbrio entre as diferentes formas de uma proteína específica (NTRK2) desempenha um papel fundamental na regeneração dos vasos sanguíneos e alvéolos pulmonares, cruciais na Displasia Broncopulmonar (DBP). Para pacientes e médicos, isso significa que entender e, potencialmente, modular esse equilíbrio pode abrir caminhos para novas estratégias de tratamento, visando promover uma melhor cicatrização e desenvolvimento pulmonar em bebês prematuros afetados pela DBP.
🇧🇷 traduzidoFlavin adenine dinucleotide increases antioxidant availability and protects neonatal C57Bl6 lungs from high oxygen induced lung injury.
Este estudo investiga o potencial do Flavin Adenine Dinucleotide (FAD) como uma nova terapia para a displasia broncopulmonar (DBP), uma condição grave em recém-nascidos prematuros decorrente de lesão pulmonar induzida por alta concentração de oxigênio. Em modelos pré-clínicos, a administração intranasal de FAD demonstrou proteger os pulmões neonatais ao aumentar a disponibilidade de antioxidantes, reduzir o estresse oxidativo e a inflamação, e diminuir significativamente os escores de lesão pulmonar. Esses achados sugerem que o FAD pode ser uma estratégia promissora para modular a inflamação e proteger os pulmões de recém-nascidos da DBP.
🇧🇷 traduzidoPublicações recentes
NAVA use in infants with established bronchopulmonary dysplasia, congenital diaphragmatic hernia, and those on ECMO: a narrative literature review.
Association between route of furosemide administration and diuretic response in very preterm infants with bronchopulmonary dysplasia.
Pediatric Pulmonary Vein Stenosis and Treatment.
Non-invasive nitric oxide use for pulmonary hypertension and pulmonary vascular disease associated with bronchopulmonary dysplasia in preterm infants.
Postnatal cytomegalovirus infection and bronchopulmonary dysplasia in very low birth weight infants: Influence of diagnostic criteria and viral load in a propensity score-matched cohort study.
📚 EuropePMC4.490 artigos no totalmostrando 196
Modulation of Alveolar Macrophages by Sex as a Biological Variable.
American journal of physiology. Lung cellular and molecular physiologyWhat is the role of diuretics in the prevention and management of bronchopulmonary dysplasia?
Current treatment options in pediatricsMaternal hypertension and survival without bronchopulmonary dysplasia in preterm infants: a meta-analysis of cohort studies.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal ObstetriciansCoordinating Tracheostomy and Gastrostomy in Infants with Bronchopulmonary Dysplasia.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck SurgeryLetter regarding Pini, A., Nardini, P., Zizi, V., Molino, M., Calvani, M., Carrozzo, F., … Filippi, L. (2026). β3-adrenoceptor agonism exerts lung protection in a rat model of bronchopulmonary dysplasia. Br J Pharmacol, in press.
British journal of pharmacologyPatent Ductus Arteriosus Persistence and Neurodevelopmental Outcomes: A Restrictive Treatment Approach Does Not Compromise Neurological Development.
Acta paediatrica (Oslo, Norway : 1992)Trends in Survival and Short-Term Outcomes Among Preterm Infants Less Than 32 Weeks From 2016 to 2022: A Retrospective Cohort Study at a Tertiary Medical Center in the UAE.
CureusLongitudinal data analysis of lung aeration and gas exchange trajectories in bronchopulmonary dysplasia: the devil is in the details-authors' reply.
The Lancet regional health. EuropeImpact of a Structured Brain Care Bundle on Severe Germinal Matrix Hemorrhage-Intraventricular Hemorrhage in Very Preterm Neonates: A Retrospective Cohort Study.
Pediatric neurologyNeonatal brain abnormalities predict preschool executive functioning performance in children born very preterm.
Developmental psychologyRespiratory Outcomes in Infants and Children With Bronchopulmonary Dysplasia Living in Rural Areas.
Pediatric pulmonologyRebalancing the Neurovascular Axis: NTRK2 Isoform Equilibrium as a Determinant of Pulmonary Endothelial Regeneration.
Cell proliferationElevated Driving Pressure in Pressure-Controlled Ventilation: An Independent Risk Factor for Adverse Outcomes in Mechanically Ventilated Neonates.
Lung[Low levels of vitamin D at one month of age and its association with bronchopulmonary dysplasia in premature newborns under 32 weeks and/or under 1500 g].
Andes pediatrica : revista Chilena de pediatriaDevelopment of an interdisciplinary tool to assess severe BPD phase of illness and application evaluating impact of tracheostomy.
Journal of perinatology : official journal of the California Perinatal AssociationOffering a Potential Route to Better Neonatal ICU to PICU Transitions.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care SocietiesExtracellular vesicle-mediated transcellular mitophagy as a modulatory target for moderate hyperoxia-induced alveolar developmental arrest in bronchopulmonary dysplasia.
Free radical biology & medicineRelationships between lung ultrasound, chest CT, and echocardiographic findings in children with bronchopulmonary dysplasia: A multimodal imaging study.
Respiratory medicineUse of Aflibercept to Treat Retinopathy of Prematurity in Children with Extremely Low Birth Weight.
Journal of clinical medicineTrajectory of lung ultrasound scores in preterm infants at risk for bronchopulmonary dysplasia.
Journal of perinatology : official journal of the California Perinatal AssociationAssociation between risk-adjusted mortality and severe morbidity in very low birth weight infants: a multicenter study from the NEOCOSUR network.
Journal of perinatology : official journal of the California Perinatal AssociationThe impact of Assisted Reproductive Technology on the neonatal prognosis of newborns < 29 weeks gestational age: a retrospective case-control study.
Journal of gynecology obstetrics and human reproductionExamining the role of biologic sex on kidney outcomes in preterm neonates: A secondary analysis of the PENUT/REPAIReD study.
Pediatric nephrology (Berlin, Germany)BPD-Neo: An MRI Dataset for Lung-Trachea Segmentation with Clinical Data for Neonatal Bronchopulmonary Dysplasia.
Scientific dataOmics approaches to bronchopulmonary dysplasia: a first step in the right direction?
ThoraxFlavin adenine dinucleotide increases antioxidant availability and protects neonatal C57Bl6 lungs from high oxygen induced lung injury.
American journal of physiology. Cell physiologyThe Value of Cord Blood CXCL10 and MMP8 as Biomarkers in Predicting Bronchopulmonary Dysplasia- A Retrospective Cohort Study.
International journal of general medicineMitochondria-derived peptide MOTS-c alleviates hyperoxia-induced bronchopulmonary dysplasia in neonatal mice by activating Nrf2 pathway.
European journal of pharmacologyEuropean Consensus Guidelines on the Management of Respiratory Distress Syndrome - 2025.
NeonatologyHigh-Frequency Oscillation vs Mechanical Ventilation for Neonatal Acute Respiratory Distress Syndrome: A Randomized Clinical Trial.
JAMA network openPrevalence, perinatal risk factors and clinical outcomes of respiratory Ureaplasma species colonization in hospitalized preterm infants.
Frontiers in pediatricsECMO use in infants with bronchopulmonary dysplasia: a literature review.
Journal of perinatology : official journal of the California Perinatal AssociationBeyond bronchopulmonary dysplasia: impact of human milk feeding on long-term respiratory morbidity in very preterm infants.
European journal of pediatricsRandomised al.Phase 2b trial of rhIGF-1/rhIGFBP-3 (OHB-607) for bronchopulmonary dysplasia prevention in preterm neonates: study protocol.
BMJ paediatrics openInhibition of mitochondrial integrated stress response ameliorates ibuprofen-induced endothelial dysfunction in neonatal hyperoxia-induced lung injury.
Biochemical pharmacologyDrying Very Preterm Infants Before Plastic Wrapping at Birth: A Randomized Clinical Trial.
JAMA network openA Narrative Review of Gene-Environment Interactions in Pediatric Pulmonology.
Pediatric pulmonologyImpact of timing from last dose of dexamethasone administration to delivery, different steroid courses, and fetal number on preterm neonatal outcomes.
PloS one[A real-world study on the association between treatment of patent ductus arteriosus in extremely preterm infants and the risk of bronchopulmonary dysplasia].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatricsNeonatal Hyperoxia Induces Metabolic Reprogramming in Senescent Alveolar Macrophages, Leading to Persistent Lung Injury.
Frontiers in bioscience (Landmark edition)Decrease in intestinal microbiome diversity at birth is related to moderate and severe bronchopulmonary dysplasia in premature infants.
Pediatrics and neonatologyEarly lung ultrasound score combined with umbilical cord-blood procalcitonin improves 1-year prognostic stratification in preterm neonates with respiratory distress syndrome.
Frontiers in pediatricsElectrical Activity of the Diaphragm (Edi) Metrics in Premature Infants Receiving Invasive Mechanical Ventilation Versus Noninvasive Respiratory Support.
CureusTailoring Therapy to Bronchopulmonary Dysplasia Phenotype: A Ten-Year Experience in Precision Medicine.
Children (Basel, Switzerland)Physiology-Based Diagnosis and Management of Bronchopulmonary Dysplasia Associated Pulmonary Hypertension (BPD-PH).
Children (Basel, Switzerland)Pulse Oximetry Histogram Profiles Before and After Red Blood Cell Transfusion in Very Preterm Infants: A Prospective Observational Cohort.
Children (Basel, Switzerland)Novel translational pulmonary MRI in pediatrics: A Review of the last 10 years.
The European respiratory journalNEC-Associated Bronchopulmonary Dysplasia and the Gut-Lung Axis in Preterm Infants.
American journal of perinatologyEarly predictors of cognitive trajectories from birth to adolescence in children born extremely preterm.
Developmental medicine and child neurologyPlasma Extracellular Vesicles from Bronchopulmonary Dysplasia Infants Initiate Inflammation and Abnormal Angiogenesis in Neonatal Murine Retinas.
CellsLabel-free optical fingerprints of hyperoxia-induced lung alterations in preterm rabbits.
Respiratory researchTitrating cumulative neonatal hyperoxia in mice to model bronchopulmonary dysplasia severities.
American journal of respiratory cell and molecular biologyCD44 is critical for TLR4-mediated NLRP3 inflammasome activation and the development of BPD.
American journal of respiratory cell and molecular biologyPulmonary Vascular Growth in Bronchopulmonary Dysplasia Using Magnetic Resonance Imaging.
American journal of respiratory and critical care medicineImpaired Taurine Transport Contributes to Bronchopulmonary Dysplasia: A Systems Biology Analysis.
American journal of respiratory cell and molecular biologyIGF1/IGFBP3 as a therapy to decrease the incidence and severity of Bronchopulmonary Dysplasia: A journey from basic science to bedside and back.
American journal of respiratory and critical care medicineRecombinant human IGF-1 complex preserves lung development in mechanically ventilated preterm lambs.
American journal of respiratory and critical care medicineEarly prediction of bronchopulmonary dysplasia using new classification in high-risk preterm infants.
Clinical and experimental pediatricsElectrical impedance tomography reveals ventilation and perfusion heterogeneity in infants with bronchopulmonary dysplasia.
Journal of perinatology : official journal of the California Perinatal AssociationEffects of higher caffeine dosing on rates of bronchopulmonary dysplasia and neurodevelopmental outcomes.
Journal of perinatology : official journal of the California Perinatal AssociationDexmedetomidine and midazolam usage and association with BSRI scores in preterm infants with chronic respiratory failure.
Journal of perinatology : official journal of the California Perinatal AssociationClinical utility of echocardiography in bronchopulmonary dysplasia: a retrospective cohort study.
Jornal de pediatriaIn-Hospital Outcomes of Very Preterm and Very Low Birth Weight Neonates: A Multicenter Retrospective Study from India.
Indian pediatricsAngiogenic factors and fetal Doppler for predicting adverse pregnancy outcome in early-onset small fetuses with and without pre-eclampsia.
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and GynecologyOutcomes of children after initiation of home mechanical ventilation via tracheostomy: a single center retrospective study.
BMC pulmonary medicineKD-SqueezeNet: an efficient deep learning strategy for the multi-task diagnosis of neonatal lung diseases.
Pediatric radiologyDo different lipid emulsions affect brain development? A single-center retrospective analysis.
Frontiers in nutritionPharmacokinetics, safety and preliminary efficacy study of montelukast in critically ill infants with developing bronchopulmonary dysplasia (PRISM).
Contemporary clinical trials communicationsEarly Prophylactic Hydrocortisone and Bronchopulmonary Dysplasia-Free Survival in Extremely Preterm Infants.
JAMA network openPeri and Neonatal Risk Factors and Structural Lung Abnormalities Predict Hypoxic Challenge Test Failure in Infants With Severe Bronchopulmonary Dysplasia.
Pediatric pulmonologyOutcomes and complications of invasive versus non-invasive respiratory support in extremely preterm infants: a retrospective study.
BMC pediatricsAn automated morphometric approach to evaluate distal lung patterning in mouse models of bronchopulmonary dysplasia.
PloS onePredicting pulmonary hypertension in infants with bronchopulmonary dysplasia.
Journal of perinatology : official journal of the California Perinatal AssociationResults of a pulmonary hypertension screening program for premature infants with bronchopulmonary dysplasia.
Journal of perinatology : official journal of the California Perinatal AssociationA non-invasive diagnostic tool for the assessment of optimal positive-end expiratory pressure (PEEPOPT) in infants receiving prolonged invasive ventilation.
Journal of perinatology : official journal of the California Perinatal AssociationPKM2 Promotes Glycolysis in Alveolar Macrophages and Induces Inflammation in Bronchopulmonary Dysplasia.
InflammationCommon Biomarkers in Chronic Obstructive Pulmonary Disease and Bronchopulmonary Dysplasia: A Narrative Review of an Intriguing Interplay.
International journal of molecular sciencesFOXF2 regulates pericyte-endothelial signaling required for vascular homeostasis after neonatal hyperoxic lung injury.
Nature communicationsAutomatic versus manual control of oxygen and neonatal clinical outcomes in extremely preterm infants: a multicentre, parallel-group, randomised, controlled, superiority trial.
The Lancet. Child & adolescent healthTrends and Contributing Factors Affecting Survival and Neurodevelopmental Outcomes in Infants Born at ≤25 Weeks' Gestation: A Retrospective Single-Center Study.
American journal of perinatologyEarly Maturation of Heart Rate Variability in Very Preterm Infants Depends on Neonatal Factors and Is Associated With Neurodevelopmental Risk.
Acta paediatrica (Oslo, Norway : 1992)Differential Trajectories of Airway and Parenchymal Function in Infants Born Preterm.
The Journal of pediatricsStress exposure, stress responses, and short-term outcomes in very preterm neonates: a national cohort study.
European journal of pediatricsElective HFOV vs CMV as Early Intervention: A Clinical Trial in Neonates with Acute Respiratory Distress Syndrome.
Advanced biomedical researchDisease Spectrum of Human Metapneumovirus Infections in Infants and Young Children: Data From a Prospective Multicenter Study in Germany.
The Pediatric infectious disease journalThe association between bronchopulmonary dysplasia severity and neurodevelopmental disorders.
Journal of perinatology : official journal of the California Perinatal AssociationNeighborhood Opportunity and Early Life Indicators of Respiratory Health in Children Born Very Preterm.
Pediatric pulmonologyOutcome after Selective early treatment for Closure of patent ductus ARteriosus in preterm babies, a multicentre, masked, randomised placebo-controlled parallel group trial (Baby-OSCAR trial).
Health technology assessment (Winchester, England)Macrolides for the prevention of bronchopulmonary dysplasia in preterm neonates.
The Cochrane database of systematic reviewsPerinatal outcomes in neonates referred to social services in a tertiary neonatal intensive care unit from a resource-limited setting: a five-year study.
Frontiers in pediatricsThe Effectiveness of Respiratory Syncytial Virus Prophylaxis Programme using Palivizumab in Preterm Infants: A single institute retrospective study.
Sultan Qaboos University medical journalExercise Capacity and Ventilatory Response in Children Who Were Born Preterm, With and Without Bronchopulmonary Dysplasia.
Pediatric pulmonologyBeyond the Echocardiogram: Cardiac Catheterization in Infants with Bronchopulmonary Dysplasia Associated Pulmonary Hypertension.
The Journal of pediatricsIndole-3-Propionic Acid Improves Alveolar Development Impairment via Targeting VAMP8-mediated SNAREs Complex Formation in Bronchopulmonary Dysplasia.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)Apgar Score Plus Umbilical Artery pH and Adverse Neonatal Outcomes in Very Preterm Infants.
JAMA network openGut microbiota and metabolomic changes across preterm stages: potential associations with bronchopulmonary dysplasia.
Microbiology spectrumVariable clinical and hemodynamic effect of sildenafil in extreme premature infants with bronchopulmonary dysplasia-associated pulmonary hypertension.
Journal of perinatology : official journal of the California Perinatal AssociationFrom Pathway to Practice: Implementing Evidence-Based Quality Improvement for ELBW Care.
American journal of perinatologyDiagnostic potential of serum miR-197 and IL-18 levels in predicting bronchopulmonary dysplasia: a prospective cohort study.
BMC pediatricsReversible Airway Obstruction on Impulse Oscillometry in Preschool Children with Bronchopulmonary Dysplasia.
The Journal of pediatricsEarly-onset preeclampsia: gestational age threshold of potential benefits.
European journal of obstetrics, gynecology, and reproductive biologyIFN-γ and TNF-α Impair Lung Development by Upregulating SMAD7 to Inhibit TGF-β Signaling Pathway and ECM Dysregulation.
InflammationCo-occurrence network analysis reveals novel associations between the neonatal airway microbiome and bronchopulmonary dysplasia risk: an observational, population-based study.
mSphereBreathe Easier: Optimizing Continuous Positive Airway Pressure in the Neonatal Intensive Care Unit.
Advances in neonatal care : official journal of the National Association of Neonatal NursesPatient-derived lung organoids from bronchoalveolar lavage capture epithelial heterogeneity and disease biology in bronchopulmonary dysplasia.
Redox biologySodium propionate alleviates bronchopulmonary dysplasia by inhibiting ferroptosis through the SLC7A11/GPX4 pathway in pulmonary endothelial cells.
Respiratory researchSurvival without bronchopulmonary dysplasia in extremely preterm infants: an external, population-based validation, comparison and optimisation study of recent prediction models at baseline.
Archives of disease in childhood. Fetal and neonatal editionPerinatal and Maternal Outcomes by Indication for Delivery in the Second Trimester.
American journal of perinatologyDesaturations with or without Bradycardia Are Associated with Cerebral and Abdominal Hypoxemia: Secondary Analysis of a Randomized Clinical Trial.
NeonatologyAnalysis of the Role of Gene Variants in Matrix Metalloproteinases and Their Tissue Inhibitors in Bronchopulmonary Dysplasia (BPD): A Study in the Polish Population.
Current issues in molecular biologyDietary and complementary oral supplements for the management of chronic diseases in children: a systematic review.
Frontiers in pediatricsPrevalence and early-life risk factors of asthma in preterm adolescents: a cohort study.
Frontiers in pediatricsImmune profiles and growth outcomes in very and extremely preterm infants with bronchopulmonary dysplasia: A prospective cohort study.
Pediatrics and neonatologyEndothelial MLKL Inhibition Reduces Hyperoxia-Induced Bronchopulmonary Dysplasia in Neonatal Mice.
Journal of cellular and molecular medicineVariations in bronchopulmonary dysplasia prevalence and outcomes by definition: a multicentre cohort study from the Chinese Neonatal Network.
BMJ openPostnatal Cytomegalovirus Infection in a Neonatal Intensive Care Unit: A Retrospective Study.
CureusLung Ultrasound in Bronchopulmonary Dysplasia: A Comparative Diagnostic Study With CT, Chest x-Ray and Pulmonary Function Tests.
Journal of paediatrics and child healthRisk Factors for Postnatal Growth Faltering and Undernutrition at Discharge in Very Preterm Infants: A Retrospective Study Applying the ESPGHAN Consensus Definitions.
NutrientsThe Impact of Enteral Nutrition Type, Volume, and Time of Introduction on the Risk of Growth Failure and Bronchopulmonary Dysplasia in Preterm Infants.
NutrientsEndotracheal Intubation in Early Life and Its Association with Mental Health Disorders from Childhood to Adolescence: A National Longitudinal Cohort Study up to Age 18.
Journal of clinical medicineNon-Invasive Surfactant Administration in Preterm Infants.
Children (Basel, Switzerland)Respiratory Sequelae of Prematurity in School-Age Children: Is Bronchopulmonary Dysplasia Still the Primary Risk Factor?
Children (Basel, Switzerland)Association of Bach1 Gene Polymorphisms with Susceptibility to Bronchopulmonary Dysplasia in Preterm Infants.
BiomedicinesPharmacologic Inhibition of S-Nitrosoglutathione Reductase Prevents Hyperoxic Alveolar and Airway Disease in Newborn Mice.
BiomedicinesBPD prediction model for very preterm infants integrating chest X-ray scores within 7 days: a retrospective case-control study.
BMJ openEstablishment of a rat model of bronchopulmonary dysplasia complicated with pulmonary hypertension and its potential applications.
Human & experimental toxicologyIdentifying the risk factors of autism spectrum disorders in infants born preterm: a systematic review and meta-analysis.
European child & adolescent psychiatryComplications of Interventional Versus Surgical Closure of Patent Ductus Arteriosus in Very Preterm Infants-A Retrospective Analysis.
Journal of cardiovascular development and diseasePostnatal corticosteroids and bronchopulmonary dysplasia: balancing pulmonary and neurologic effects to enable individualized decision-making.
Current opinion in pediatricsTransfusion of blood products and neonatal outcomes in preterm infants: A retrospective cohort study.
TransfusionThe Effect of Vitamin A and Retinol-Binding Protein Levels in Cord Blood of Very Low Birth Weight Infants on Mortality and Morbidity.
Klinische PadiatrieMaternal inflammatory biomarkers and neonatal characteristics as predictors of bronchopulmonary dysplasia in preterm infants: a retrospective cohort study.
Frontiers in medicineLow hyper-oxygen exposure induces p21-dependent p53-independent senescence in alveolar cells.
International journal of medical sciencesDexmedetomidine attenuates hyperoxia-induced lung injury in BPD mice via regulation of the mitophagy-NLRP3-pyroptosis pathway.
Archives of biochemistry and biophysicsβ3-adrenoceptor agonism exerts lung protection in a rat model of bronchopulmonary dysplasia.
British journal of pharmacologyRespiratory Practices to Prevent or Treat Evolving Bronchopulmonary Dysplasia: A European Survey.
The Journal of pediatricsTherapeutic potential and translational challenges of extracellular vesicles in neonatal medicine.
Bioengineering & translational medicineHigh-flow nasal cannula versus CPAP for the prevention of bronchopulmonary dysplasia in preterm infants: a systematic review with meta-analysis and trial sequential analysis.
Respiratory medicineDeep Learning-Based Prediction of Cardiopulmonary Disease in Retinal Images of Premature Infants.
JAMA ophthalmologyUtilization of integrated lung ultrasound and targeted neonatal echocardiography in preterm infant follow-up: is it feasible? Assessing value and practical challenges.
European journal of pediatricsPatent ductus arteriosus: emerging trial evidence firmly supports conservative management in preterm infants.
Current opinion in pediatricsStudy protocol for the volume targeted mask ventilation versus pressure ventilation in preterm infants-the VOLT-trial.
Frontiers in pediatricsLung aeration and gas exchange in preterm infants developing moderate-to-severe bronchopulmonary dysplasia: a multicentre prospective study from the PATH-BPD cohort.
The Lancet regional health. EuropeValidation of a new Japanese classification for predicting severe bronchopulmonary dysplasia in preterm infants.
Clinical and experimental pediatricsImpact of Nonhemodynamically Significant Patent Ductus Arteriosus on Pulmonary Function in Premature Neonates.
The Journal of pediatricsTime-Series Machine Learning for Prediction of Bronchopulmonary Dysplasia.
The Journal of pediatricsQuantitative assessment of neonatal health using dried blood spot metabolite profiles and deep learning.
Science translational medicineSuccessful perinatal management of a large placental chorio-angioma: a case report demonstrating the effectiveness of a public-private partnership model.
Paediatrics and international child healthMachine learning integrated extracellular vesicle proteome analysis for early markers of bronchopulmonary dysplasia.
Function (Oxford, England)Development and validation of a nomogram to predict bronchopulmonary dysplasia in very preterm, very low birth weight infants.
American journal of translational researchOverview of extracellular vesicles as biomarkers and therapeutic tools in pediatric diseases: focus on the gut-lung axis.
Extracellular vesicles and circulating nucleic acidsFetal hemoglobin fraction is correlated to the risk of prematurity complications.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal ObstetriciansHemodynamically significant PDA impacts adverse outcomes in infants with BPD: a multicenter study.
Pediatric researchStratified Comparison of Risk Factors for Mild Versus Moderate-to-Severe Bronchopulmonary Dysplasia in Very Preterm Infants (< 32 Weeks Gestational Age).
LungInhibition of Rho-kinase restores impaired relaxation of airway smooth muscle in rat pups exposed to neonatal hyperoxia.
Physiological reportsAssociation of birth weight Z-score with bronchopulmonary dysplasia or mortality in very preterm infants: a cohort study.
BMJ open respiratory researchImpact of early parenteral amino acid on preterm infant: A multicenter study.
Pediatrics and neonatologyEvidence-based early-post natal approaches to limiting pulmonary disease in extremely low birth weight infants.
Current opinion in pediatricsDevelopmental dynamics of bronchioalveolar stem cells revealed by dual-reporter lineage tracing.
Respiratory researchAssociations of Community Material Neighborhood Deprivation With the Diagnosis of Asthma Among Infants With Bronchopulmonary Dysplasia (BPD).
Pediatric pulmonologyAn Interventional Study on the Late Treatment of Severe Bronchopulmonary Dysplasia in Preterm Infants Using Mesenchymal Stromal Cells.
Stem cells internationalThe Use of Treprostinil for Bronchopulmonary Dysplasia Associated Pulmonary Hypertension.
Pediatric pulmonologyLung trajectories into adulthood of preterm born survivors and the influence of sex.
Paediatric respiratory reviewsRespiratory Physiotherapy in Preterm Neonates with Bronchopulmonary Dysplasia or Respiratory Distress Syndrome: A Comprehensive Review of Clinical Evidence and Therapeutic Implications.
Journal of clinical medicineTwo isoforms, two outcomes: How NTRK2 shapes vascular regeneration.
Cell stem cell3-Mercaptopyruvate Sulfurtransferase (MPST) Regulates Mitochondrial Metabolism and Epithelial Differentiation in Neonatal Patient-derived Airway Cells.
bioRxiv : the preprint server for biologyLung ultrasound features during the evolution of BPD: a study from an animal model.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal ObstetriciansThe characteristics of pulmonary fibrosis in a neonatal rat model of chronic hyperoxia lung injury.
Translational pediatricsFollow-up of neonatal chronic respiratory disease: an update based on the current evidence.
European journal of pediatricsUnilateral absence of pulmonary artery presenting with pulmonary hypertension in two adults.
BMJ case reportsHospitalization Outcomes of Full-Term and Premature Children Aged Less Than 2 Years Hospitalized With RSV.
PediatricsGeneral movements and neurodevelopmental outcomes at 2 years of age in infants born very preterm.
Developmental medicine and child neurologyToward precision for bronchopulmonary dysplasia: Moving past current definitions.
Journal of perinatology : official journal of the California Perinatal AssociationThe relationship of p50 with clinical outcomes in ventilated preterm infants.
Frontiers in pediatricsThe utility of caffeine citrate as a neuroprotectant in the early life of premature newborns: a literature review of the effects on neurodevelopmental outcomes.
Frontiers in pediatricsSubglottic cysts as an uncommon cause of upper airway obstruction: a 12-year retrospective study.
Therapeutic advances in respiratory diseaseIs small for gestational age associated with reduced oxygen saturation to FiO2 ratio at 36 weeks postmenstrual age in preterm infants, independent of bronchopulmonary dysplasia? A retrospective Italian two-center cohort study.
European journal of pediatricsIn-hospital and 12-24-month neurodevelopmental outcomes in periviable infants across two epochs: a cohort study from a tertiary neonatal unit in India.
Journal of tropical pediatricsEffectiveness and feasibility of orogastric tube for surfactant delivery in moderate or very preterm neonates with respiratory distress syndrome: an open-label randomized controlled trial.
Journal of tropical pediatricsDiagnostic accuracy of lung ultrasound score for bronchopulmonary dysplasia in preterm neonates: a systematic review and meta-analysis.
Frontiers in pediatricsClinical characteristics and risk factors of severe bocavirus-positive pneumonia in children and a literature review.
Pediatric discoveryImproving Platelet Transfusion Practice.
NeoReviewsUnraveling the mechanism of alleviating hyperoxia-induced Bronchopulmonary dysplasia: miR-93-5p-mediated regulation of TNFRSF21.
Pediatrics and neonatologyNeonatologist-Performed Echocardiography in Neonatal Pulmonary Hypertension: A Narrative Review of the Literature.
Diagnostics (Basel, Switzerland)Caffeine Protects Against Hyperoxia-Induced Structural Lung Injury and Restores Alveolar Development in Neonatal Rats.
Antioxidants (Basel, Switzerland)Oxidant Stress, Hyperoxia/Hypoxia and Neonatal Respiratory Disorders.
Antioxidants (Basel, Switzerland)Analysis of the Correlation Between Serum Procalcitonin (PCT), C-Reactive Protein (CRP) Levels and the Occurrence/Severity of Bronchopulmonary Dysplasia in ELBW/VLBW Neonates.
International journal of general medicineToo Few and Far Between: The Need for New Therapies to Treat Bronchopulmonary Dysplasia and the Potential of TFF3.
Pediatric pulmonologyMitochondrial quality control mechanisms as molecular targets for impaired lung development: from fetuses to neonates.
Respiratory researchRebalancing NTRK2 isoforms promotes vascular regeneration in bronchopulmonary dysplasia.
Cell stem cellAzithromycin for the eradication of respiratory tract Ureaplasma infection and prevention of bronchopulmonary dysplasia in preterm infants: what is the current evidence?
Archives of disease in childhood. Fetal and neonatal editionOutcomes in extremely preterm neonates after the introduction of early low-dose hydrocortisone treatment: A retrospective case-control study.
Early human developmentEarly Biomedical and Environmental Factors Associated with Developmental Coordination Disorder in a Brazilian Preterm Cohort.
Brain sciences5-HT promotes bronchopulmonary dysplasia via TGM2-mediated serotonylation.
iScienceGolden hour(s) quality improvement protocols and their effect on outcomes in preterm infants ≤ 32 weeks of gestation: a scoping review.
BMC pediatricsDeterminants of volatile organic compound exposure among children with bronchopulmonary dysplasia.
Pediatric researchAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Modulation of Alveolar Macrophages by Sex as a Biological Variable.American journal of physiology. Lung cellular and molecular physiology· 2026· PMID 41874349mais citado
- What is the role of diuretics in the prevention and management of bronchopulmonary dysplasia?
- Impact of a Structured Brain Care Bundle on Severe Germinal Matrix Hemorrhage-Intraventricular Hemorrhage in Very Preterm Neonates: A Retrospective Cohort Study.
- Rebalancing the Neurovascular Axis: NTRK2 Isoform Equilibrium as a Determinant of Pulmonary Endothelial Regeneration.
- Flavin adenine dinucleotide increases antioxidant availability and protects neonatal C57Bl6 lungs from high oxygen induced lung injury.
- NAVA use in infants with established bronchopulmonary dysplasia, congenital diaphragmatic hernia, and those on ECMO: a narrative literature review.
- Association between route of furosemide administration and diuretic response in very preterm infants with bronchopulmonary dysplasia.
- Pediatric Pulmonary Vein Stenosis and Treatment.
- Non-invasive nitric oxide use for pulmonary hypertension and pulmonary vascular disease associated with bronchopulmonary dysplasia in preterm infants.
- Postnatal cytomegalovirus infection and bronchopulmonary dysplasia in very low birth weight infants: Influence of diagnostic criteria and viral load in a propensity score-matched cohort study.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:70589(Orphanet)
- MONDO:0019091(MONDO)
- GARD:5962(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
- Q922640(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
