A Síndrome Serotoninérgica é caracterizada por um excesso de serotonina no cérebro e na medula espinhal, geralmente associada ao uso de diversos medicamentos, incluindo os antidepressivos da classe dos ISRSs (inibidores seletivos de recaptação de serotonina).
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A Síndrome Serotoninérgica é caracterizada por um excesso de serotonina no cérebro e na medula espinhal, geralmente associada ao uso de diversos medicamentos, incluindo os antidepressivos da classe dos ISRSs (inibidores seletivos de recaptação de serotonina).
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Mostrando amostra de 200 publicações de um total de 751
Serotonin syndrome presenting as severe reversible cerebral vasoconstriction syndrome.
Serotonin syndrome is a life-threatening adverse drug reaction caused by excessive serotonergic activity from therapeutic use, overdose or drug interactions. Its recognition is challenging, as manifestations range from subtle to severe and fatal. Key diagnostic features are autonomic dysfunction, motor hyperactivity and exaggerated reflexes, including clonus. We report a young woman with severe serotonin syndrome due to serotonergic polypharmacy who developed reversible cerebral vasoconstriction syndrome and overlapping posterior reversible encephalopathy syndrome. The diagnosis was initially delayed because attention had focused on her prominent vascular features with severe focal neurological deficits rather than the underlying toxidrome. We diagnosed serotonin syndrome as she developed more characteristic features. This case highlights the importance of considering serotonin syndrome in patients receiving serotonergic medications who develop motor findings, autonomic dysfunction or unexplained neurological deterioration.
The effect of fentanyl combined with linezolid on in-hospital mortality in mechanically ventilated patients: A retrospective cohort study.
The combination of linezolid and opioid drugs such as fentanyl may increase the risk of serotonin syndrome, but its impact on in-hospital mortality is not yet clear. The aim of this study is to investigate the effect of simultaneous use of fentanyl and linezolid on in-hospital mortality in mechanically ventilated patients. Based on the MIMIC-IV database, 3339 patients receiving mechanical ventilation were enrolled and divided into three groups: the group receiving linezolid simultaneously (n = 43), the group receiving linezolid within 14 days (n = 22) and the group that did not use linezolid (n = 3274). Use multivariate Cox regression analysis to analyze in-hospital mortality rates and adjust for confounding factors. The in-hospital mortality rate of the group receiving linezolid simultaneously was 37.2% (16/43), the group receiving linezolid within 14 days was 40.9% (9/22), and the group that did not use linezolid was 22.9% (751/3274). The in-hospital mortality rate of the group receiving linezolid simultaneously was significantly higher than that of the group that did not use linezolid (hazard ratio [HR], 1.56; 95% CI, 1 ~ 2.43; P = 0.049). There was no statistically significant difference in in-hospital mortality rate among the group receiving linezolid within 14 days and the group that did not use linezolid (hazard ratio [HR], 1.01; 95% CI, 0.5 ~ 2.05; P = 0.968). Subgroup analysis showed that there was no interaction between different groups at baseline (age, gender, race, BMI, liver disease, and kidney disease) (interaction p-value > 0.05). In this post-hoc analysis, we found an association between the combined use of fentanyl and linezolid and increased in-hospital mortality among mechanically ventilated patients. However, this finding is based on studies with small sample sizes and requires further validation through larger, multicenter investigations. In clinical practice, the potential risks of this drug interaction should be carefully evaluated.
Comment on "Selective Serotonin Reuptake Inhibitors and Risk of Serotonin Syndrome as a Consequence of Drug-Drug Interactions".
Chronic tramadol abuse as a cause of serotonin syndrome.
Serotonin syndrome is characterized by autonomic hyperactivity, altered mental status, and neuromuscular abnormalities, ranging from mild to life-threatening manifestations. Tramadol has been associated with serotonin syndrome, predominantly in combination with other serotonergic agents or following acute overdose. Reports describing serotonin syndrome caused by chronic high-dose tramadol use as a single serotonergic agent are scarce. A case of serotonin syndrome in a young adult with chronic high-dose tramadol dependence in the absence of co-ingested serotonergic drugs is presented. A 22-year-old man with tramadol dependence (800 mg daily) presented to the emergency department with anxiety and agitation. Physical examination revealed diaphoresis, mydriasis, tachycardia (130 beats/min), hypertension (140/100 mmHg), hyperreflexia, and inducible ankle clonus. Laboratory investigations, head computed tomography, and urine toxicology screening were unremarkable. Based on the presence of inducible clonus and hyperreflexia in the setting of serotonergic exposure, the Hunter Serotonin Toxicity Criteria were fulfilled. Tramadol was discontinued and replaced with methadone. The patient recovered completely within 48 h. This case illustrates that chronic high-dose tramadol use alone may precipitate serotonin syndrome. Clinicians should remain alert to this potentially life-threatening complication, even in the absence of concomitant serotonergic medication.
The interplay between serotonin syndrome and syndrome of inappropriate antidiuresis: a fatal case of acute hyponatremia during treatment with duloxetine, chlorphenamine, amitriptyline, and L-tryptophan.
Serotonin syndrome (SS) and hyponatremia are severe, potentially life-threatening adverse reactions to serotonergic medications. Their concurrent manifestation is rare but clinically significant due to overlapping pathophysiological mechanisms. This report describes the fatal outcome of a 30-year-old female who presented to the Emergency Department with agitation following self-administration of duloxetine 60 mg, in addition to ongoing amitriptyline therapy and possible L-tryptophan supplementation. During hospitalization, she was treated with intravenous chlorphenamine for a suspected allergic reaction. Subsequently, she developed severe neurological deterioration, malignant arrhythmia, and profound acute hyponatremia (serum sodium 114 mmol/L), culminating in brain death within 48 h. The synergistic pharmacodynamic and pharmacokinetic interactions between duloxetine, amitriptyline, and chlorphenamine-three agents with serotonin reuptake inhibition properties-were implicated in precipitating SS and syndrome of inappropriate antidiuresis (SIAD)-induced hyponatremia. This combination resulted in extensive cerebral edema and cardiopulmonary arrest. The case highlights the diagnostic challenge posed by overlapping SS and hyponatremia manifestations, particularly when compounded by incomplete pharmacological histories and inappropriate drug administration. Clinicians should maintain high vigilance for SS and hyponatremia in patients receiving serotonergic agents, especially when multiple such drugs are co-administered. Comprehensive medication anamnesis, prompt electrolyte monitoring, and avoidance of pharmacodynamic duplication are essential to prevent similar outcomes.
Publicações recentes
Anticholinergic burden in fibromyalgia treatment analysis: Guidelines adherence and pharmacological alerts.
Case Report: Pharmacogenetically-triggered fatal serotonin syndrome following sequential serotonergic therapy in Parkinson's disease: a case highlighting the role of CYP2D6*10/*10 genotype and multifactorial drug interactions.
Serotonin syndrome risk with concomitant opioid and serotonergic antidepressant use: a multinational pharmacovigilance study.
Uveal Effusion and Exudative Macular Detachment Secondary to SSRI and Dexamphetamine Overdose.
Efficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative Action: A Review of Clinical Data and Toxicological Risks.
📚 EuropePMC989 artigos no totalmostrando 194
Chronic tramadol abuse as a cause of serotonin syndrome.
Toxicology reportsThe interplay between serotonin syndrome and syndrome of inappropriate antidiuresis: a fatal case of acute hyponatremia during treatment with duloxetine, chlorphenamine, amitriptyline, and L-tryptophan.
Therapeutic advances in psychopharmacologySevere 3,4-Methylenedioxymethamphetamine (MDMA)-Associated Rhabdomyolysis in Crohn's Disease: Direct Toxicity and Inflammatory Susceptibility in the Absence of Hyperthermia.
CureusSerotonin syndrome presenting as severe reversible cerebral vasoconstriction syndrome.
Practical neurologyCocaine-Induced Rhabdomyolysis With Acute Kidney Injury in the Absence of Serotonin Syndrome: A Case Report.
CureusSertraline and quetiapine induced Serotonin Syndrome and Neuroleptic Malignant Syndrome: a case report.
BMC psychiatrySafety Concerns, Mechanistic Pathways, and Knowledge Gaps in the Clinical Use of Selective Serotonin Reuptake Inhibitors.
CureusSurvival Following a Tricyclic Antidepressant Overdose Presenting With Serotonin Syndrome-Like Symptoms and Critical Illness Polyneuropathy: A Case Report.
CureusAdverse events related to buspirone: a real-world pharmacovigilance study using the FAERS database.
Journal of affective disordersQuestion: How Is it Possible That Phenelzine Combined With Dextromethorphan Could Cause Serotonin Syndrome?
Journal of clinical psychopharmacologyThe effect of fentanyl combined with linezolid on in-hospital mortality in mechanically ventilated patients: A retrospective cohort study.
PloS oneMethylene Blue and Serotonin Syndrome: A Caution Against Intravenous Use.
Urogynecology (Philadelphia, Pa.)Triggers of highly lethal seizures induced by novel stimulants: A systematic review focused on synthetic cathinones and phenethylamines.
NeurotoxicologyVenlafaxine-induced serotonin syndrome causing bilateral cerebral strokes: a case report.
Frontiers in strokeCross-national differences in methylphenidate utilization in primarily adult psychiatric inpatients.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological PsychiatryThe evolving serotonin syndrome spectrum: from acute syndrome to smoldering presentations and personalized risk management.
Expert opinion on drug metabolism & toxicologySerotonin Syndrome Versus Neuroleptic Malignant Syndrome in a Pediatric Patient Receiving Fluoxetine and Haloperidol: A Case Report.
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAGKnowledge, attitudes, and practices toward linezolid-serotonergic drug interactions: a cross-sectional study.
Frontiers in pharmacologySerotonin Syndrome With Quetiapine, Rizatriptan, Gabapentin, and Propranolol.
The primary care companion for CNS disordersCarisoprodol poisoning with serotonin toxicity.
BMJ case reportsTime Course of Serum Dextromethorphan Concentrations in a Case of Serotonin Syndrome After Massive Overdose.
The American journal of case reportsSerotonin syndrome induced by Bromfed DM in a patient on sertraline.
SAGE open medical case reportsEvaluation of clinical findings in predicting the development of serotonin syndrome: can the Hunter's criteria be used in children?
Postgraduate medicineWhen Parkinson's disease encounters high fever: two case reports and literature review.
American journal of translational researchSerotonin syndrome: understanding pathophysiological bases and managing a growing clinical challenge.
Neurologia i neurochirurgia polskaReal-world pharmacovigilance and clinical risks of fluvoxamine: A disproportionality analysis based on FAERS data.
Journal of affective disordersDrug-associated serotonin syndrome in elderly patients: a comprehensive disproportionality analysis based on the FAERS database.
Frontiers in pharmacologyDelayed Serotonin Syndrome Following the Concurrent Use of an Unregulated Supplement and Selective Serotonin Reuptake Inhibitors (SSRIs): A Case Report.
CureusAnesthetic implications of psychotropic medications: a narrative review.
Journal of Yeungnam medical scienceIdentifying Early Presentation of Serotonin Syndrome in a 20-Year-Old Man Prescribed Clomipramine and Quetiapine: A Case Report.
CureusFatal outcome of severe serotonin syndrome and acute respiratory distress syndrome after self-poisoning with paroxetine: a case report.
Journal of medical case reportsA Real-World Pharmacovigilance study of FAERS Database for Fluvoxamine: Perspectives from Physicians and Pharmacists.
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Polypharmacy-induced serotonin syndrome revealing underlying neurocognitive impairment and cervical myelopathy.
BMJ case reportsExploring drug interactions between newer antidepressants and medications used to treat neurological disorders.
Expert opinion on drug metabolism & toxicologyIntracranial Pressure-Guided Therapy in 3,4-Methylenedioxymethamphetamine (MDMA)-Induced Cerebral Edema: A Case Report.
CureusTrauma-induced Catatonia in Pediatric Patients: Case Series and Literature Review.
Journal of child & adolescent traumaThree Distinct Neuropsychiatric Syndromes Following Pineal Teratoma Resection.
Journal of child and adolescent psychopharmacologyA Narrative Review on Toxidromes in the Psychiatric Population: Implications for Overdose Prevention.
Journal of clinical medicineConcomitant use of antidepressants and classic psychedelics: A scoping review.
Journal of psychopharmacology (Oxford, England)Discordance in Drug-Drug Interaction Alerts for Antidotes: Comparative Analysis of Electronic Databases and Interpretive Insights from AI Tools.
Drug design, development and therapyNeuroleptic Malignant Syndrome in an Institutionalized Geriatric Patient Following Antipsychotic Switch to Quetiapine: A Fatal Outcome.
CureusSerotonin Syndrome Masquerading as Alcohol Withdrawal: A Case Report.
Journal of addictive diseasesThe Overlap of Posterior Reversible Encephalopathy Syndrome and Reversible Cerebral Vasoconstriction Syndrome: A Report of a Complex Case and Challenges With Its Management.
CureusSerotonin syndrome following spinal anaesthesia for elective caesarean delivery: a case report.
International journal of obstetric anesthesiaAn Analytic Review of Neuropsychiatric Syndromes in the Intensive Care Unit.
Journal of intensive care medicineNeurological adverse events associated with antidepressants: a comprehensive 22-year analysis of the FDA adverse event reporting system.
Frontiers in pharmacologySafety of antidepressants commonly used in 6-17-year-old children and adolescents: A disproportionality analysis from 2014-2023 on the basis of the FAERS database.
PloS oneA practical approach to managing agitated toxidromes.
Tropical doctorInvestigation into the Effects of Tramadol, Citalopram, Tianeptine, and Their Combinations on Rat Brain Tissue.
BiomedicinesGeneralized Myoclonus in an Elderly Patient on Risperidone: A Rare but Important Adverse Effect.
Case reports in psychiatryMAO inhibitors for treatment-resistant depression: Bringing an updated perspective on pioneering drugs.
Pharmacological researchSerotonin Syndrome Without Overdose: Polypharmacy-Induced Toxicity in a Medically Stable Young Adult.
CureusLinezolid in combination with pentazocine causes serotonin syndrome: A case report.
MedicineA case of serotonin syndrome following the reintroduction of aripiprazole after dextromethorphan overdose.
PCN reports : psychiatry and clinical neurosciencesFatalities following DMT use: two case reports and a review of the literature.
Journal of analytical toxicologyThe Effect of Antibiotics on the Nervous System: Importance for Anesthesiology and Intensive Care.
Antibiotics (Basel, Switzerland)Posterior Reversible Encephalopathy Syndrome Induced by Mirtazapine Overdose: A Case Report.
Case reports in neurological medicineA case of bupropion overdose: Bupropion intoxication and/or serotonin syndrome?
Psychiatria DanubinaProlonged Serotonergic Symptoms in a Pediatric Patient: Suspected Interaction Between Prescription Medications and Kava Supplement.
CureusFrom Theory to Therapy: Methylene Blue's Emerging Role in the Management of Septic Shock.
Journal of pharmacy practiceDisproportionality analysis of serotonin syndrome associated with selective serotonin reuptake inhibitors: a pharmacovigilance analysis.
European journal of clinical pharmacologyDefinitive urine drug testing in emergency medicine: Recreational and psychiatric drug findings.
Journal of mass spectrometry and advances in the clinical labCase Report: Neuroleptic malignant syndrome in a 15-year-old female following of psychotropic drugs.
Frontiers in psychiatryRisk Assessment of Linezolid-Associated Neurological Adverse Drug Reactions Based on the Food and Drug Administration Adverse Event Reporting System Database.
Journal of multidisciplinary healthcareAdverse events associated with four atypical antipsychotics used as augmentation treatment for major depressive disorder: A pharmacovigilance study based on the FAERS database.
Journal of affective disordersAcute Febrile Encephalopathy with Rigidity.
Journal of intensive care medicinePostoperative Serotonin Syndrome Triggered by Propofol in a Patient on Chronic Serotonergic Medications and Bupropion: A Case Report.
CureusDevelopment and Validation of an Approach to Assessing Clinical Relevance of Potential Drug-Drug Interactions Inducing Rare but Serious Adverse Events.
Clinical and translational scienceIsoniazid-Associated Serotonin Toxicity in the Critical Care Setting: A Case Report.
CureusCatatonia: American Psychiatric Association Resource Document.
Journal of the Academy of Consultation-Liaison PsychiatrySingle-Substance SSRI Intoxication: A Clinical and Outcome Profile Presentation in a Poisoning Referal Center.
Emergency medicine internationalOpsoclonus-Myoclonus: Not Always Paraneoplastic.
Movement disorders clinical practiceA Translational Model-Based Meta-Analysis to Predict Tremor Incidence Associated with Serotonin Reuptake Transporter Inhibition.
Clinical pharmacology and therapeuticsSelective Serotonin Reuptake Inhibitors and Risk of Serotonin Syndrome as Consequence of Drug-Drug Interactions: Analysis of the FDA Adverse Event Reporting System.
Medical principles and practice : international journal of the Kuwait University, Health Science CentrePrevalence of Serotonergic Drug Use in Patients Exposed to Perioperative Methylene Blue: A Cross-Sectional Study.
CureusSerotonin syndrome induced through a combination of oxycodone and amitriptyline: A case report.
Psychiatry and clinical neurosciencesSerotonin syndrome as a cause of delirium.
BMJ supportive & palliative careAntidepressant and antiobesity drug-induced serotonin syndrome complicated by multiple organ injury: A case report.
MedicineRhabdomyolysis and Acute Kidney Injury: Exploring the Potential Causes in a Hospitalized Patient.
CureusCombinations of compound cold medicines should be used with caution: a case series.
Frontiers in medicineClinical effects of acute lamotrigine overdose (ATOM-10).
Clinical toxicology (Philadelphia, Pa.)Postoperative Serotonin Syndrome: A Case Report Highlighting Dexmedetomidine for Refractory Symptoms.
CureusA fatal intoxication case due to the serotonin syndrome induced by dextromethorphan and moclobemide overdose.
Legal medicine (Tokyo, Japan)Serotonin Syndrome Associated With High-dose Diphenhydramine Use Complicating Abdominoplasty and Mastopexy.
Plastic and reconstructive surgery. Global openAnaesthetic implications of psilocybin and lysergic acid diethylamide: what is old is now new: A narrative review on psychedelics and anaesthesia.
European journal of anaesthesiologyTramadol and mental health: A systematic review of case reports describing psychological side-effects.
International journal of psychiatry in medicineLinezolid and serotonin syndrome.
The Journal of international medical researchNoticeable changes in diaphoresis severity following pain management medication adjustments in a complex regional pain syndrome patient.
Anesthesia and pain medicineLinezolid and tedizolid adverse effects: a review on serotonin syndrome, myelosuppression, neuropathies, and lactic acidosis.
Antimicrobial stewardship & healthcare epidemiology : ASHESerotonin Syndrome With Concomitant Antidepressant and Tramadol: A Case Report.
CureusMitigative and neuroprotective effects of Lavandula angustifolia essential oil on serotonin syndrome-induced neurotoxicity in male albino rats.
Drug and chemical toxicologyConcomitant Use of Etrasimod With Opioids or Antidepressants in Patients With Ulcerative Colitis-A Safety Analysis.
United European gastroenterology journalPreparation and pharmacokinetic evaluation of a sertraline-methylpropyphenazone prodrug: a comparative metabolic study on the plasma and brain tissues of rats using LC-MS/MS analysis.
RSC advancesComparison of clinicodemographic characteristics in patients with selective serotonin reuptake inhibitors poisoning: A cross-sectional study.
Medical journal, Armed Forces IndiaEvaluating the risk of mild serotonin syndrome in primary care: a retrospective case series of patients with treatment-resistant depression.
AME case reportsDrug-Induced Myoclonus: A Systematic Review.
Medicina (Kaunas, Lithuania)Challenges in the Management of Severe Serotonin Syndrome: A Case Report.
CureusThe impact of borneolum on Citalopram hydrobromide pharmacokinetics and serotonin levels in the hypothalamus of conscious rats.
Natural product researchReview article: Efficacy of cyproheptadine in the management of serotonin toxicity following deliberate self-poisoning - A systematic review.
Emergency medicine Australasia : EMANeurological Insights: Transient Unilateral Relative Afferent Pupillary Defect in the Context of Serotonin Syndrome.
CureusContemporary Perspectives in Critical Care of Neuroleptic Malignant Syndrome.
Neurocritical careAn Older Man with Clonus, Rigidity, Hyperreflexia, and Hand Tremors.
Journal of pain & palliative care pharmacotherapySerotonin Syndrome in Parkinson's Disease: Don't Get It Confused by a Tremor.
CureusInvestigation of Pharmacokinetic and Pharmacodynamic Interactions between Citalopram and Duloxetine: An Integrated Analytical, Computational, Behavioral, and Biochemical Approach.
ACS pharmacology & translational scienceChronic Serotonin Syndrome Masquerading as Anxiety and Agitation in a Patient With Mood Disorder: A Clinical Dilemma!
Bipolar disordersSerotonin Syndrome with Propofol and Remifentanil: Mechanistic Concern and Alternative Diagnosis.
A&A practiceDelayed diagnosis of basilar artery occlusion in a 28-year-old postpartum woman.
BMC neurologyStructural Conversion of Serotonin into Amyloid-like Nanoassemblies Conceptualizes an Unexplored Neurotoxicity Risk.
ACS nanoLARGE-SCALE BRAIN NETWORKS IN CHRONIC AND SMOLDERING SEROTONIN SYNDROME.
Psychiatria Danubina[Serotonin syndrome secondary to the association of paroxetine and amitriptyline: a case report].
The Pan African medical journalManagement of Suspected α-Pyrrolidinoisohexanophenone (α-PiHP)-Related Hyperthermia in a Young Adult: A Case Report.
CureusMedication-overuse headache overlapping with serotonin syndrome.
Drug and therapeutics bulletinBipolar Disorder in a Young Adult With Thalassemia Major With Sequential Development of Neuroleptic Malignant Syndrome and Serotonin Syndrome.
Journal of clinical psychopharmacologyRecognizing serotonin syndrome in the intensive care unit: a case report of serotonin syndrome in a patient taking amitriptyline, buprenorphine, pregabalin, and fentanyl.
AME case reportsPsychiatric Etiologies and Approaches in Altered Mental Status Presentations: Insights from Consultation Liaison Psychiatry.
Seminars in neurologyA False-positive Diagnosis of a Lethal Serotonin Syndrome Based on Postmortem Whole-blood Levels of Sertraline: How Forensic Detective Work Uses Medical Knowledge and Clinical Pharmacology to Solve Cases.
Journal of psychiatric practiceCyproheptadine is preferable to benzodiazepines in mild cases of serotonin syndrome (toxicity).
British journal of clinical pharmacologyAdvising patients on serotonin syndrome in General Practice.
British journal of clinical pharmacologySerotonin syndrome caused by escitalopram in Parkinson's disease psychosis: a case report.
BMC geriatricsIncidence of serotonin syndrome in patients receiving tedizolid and concomitant serotonergic agents.
Antimicrobial agents and chemotherapyAn Unexpected Presentation of Serotonin Syndrome in a Patient Receiving ECT.
Case reports in psychiatryPredictors of Serotonin Syndrome in Acute Poisoning with 5-Hydroxytryptamine Modulators.
ToxicsSerotonin syndrome: A rare yet crucial diagnosis.
JAAPA : official journal of the American Academy of Physician AssistantsSerotonin Syndrome Induced by Fentanyl Alone in an Adult Patient After Cardiac Surgery: A Case Report.
CureusBronchial carcinoid: a neuroendocrine manifestation-presented as bronchospasm and hypertension during resection.
Indian journal of thoracic and cardiovascular surgeryAnalytically Confirmed Intentional Overdose of the Antidepressant Vortioxetine.
Journal of medical toxicology : official journal of the American College of Medical ToxicologyPrevalence of contraindicated combinations amid behavioral and mental health medications filled in a pediatric population.
BMC primary careA Case study of polypharmacy-induced serotonin syndrome in a cancer patient.
Journal of the American Association of Nurse PractitionersAcute clomipramine exposure elicits dose-dependent surfacing behavior in adult zebrafish (Danio rerio).
PeerJConcomitant Administration of Ozanimod and Serotonergic Antidepressants in Patients With Ulcerative Colitis or Relapsing Multiple Sclerosis.
Inflammatory bowel diseasesAnalgesic treatment for refractory cancer pain caused by gastric cancer bone metastasis: A case report and literature review.
MedicineSerotonin Syndrome-Mimicking Manifestations in a Patient with Systemic Lupus Erythematosus.
Journal of clinical medicineSerotonin syndrome controversies: A need for consensus.
World journal of critical care medicineHypertensive Crisis Associated with Serotonin Syndrome Following Linezolid Administration: Report of Two Cases.
Current drug safetySerotonin Syndrome After Prolonged Remifentanil and Propofol Infusion for Craniotomy: A Case Report.
A&A practiceIdiopathic Serotonin Syndrome - Does It Exist?
Annals of Indian Academy of NeurologyCaution for psychiatrists: malignant hyperthermia risks with the anesthetic agent succinylcholine (Suxamethonium) during electroconvulsive therapy.
BMC psychiatryCyproheptadine in serotonin syndrome: A retrospective study.
Journal of family medicine and primary careNeuroleptic malignant syndrome and serotonin syndrome: a comparative bibliometric analysis.
Orphanet journal of rare diseasesRecurrent Serotonin Syndrome After Ketamine-assisted Electroconvulsive Therapy: A Case Report and Review of the Literature.
Journal of psychiatric practicePost-marketing safety concerns with lumateperone: a pharmacovigilance analysis based on the FDA adverse event reporting system (FAERS) database.
Frontiers in pharmacologyOff-label higher doses of serotonin reuptake inhibitors in the treatment of obsessive-compulsive disorder: Safety and tolerability.
Comprehensive psychiatryAltered Mental Status in an Octogenarian: How Frequently Should Serotonin Syndrome Be Considered?
CureusHaloperidol-Induced Neuroleptic Malignant Syndrome: A Case Report.
CureusAdverse reactions caused by high serum concentration of linezolid: Two case reports and literature review.
Clinical case reportsFrom Evidence to Practice: A Comprehensive Analysis of Side Effects in Synthetic Anti-Depressant Therapy.
Current drug safetyA fatal case of desvenlafaxine and paroxetine poisoning.
Journal of pharmaceutical and biomedical analysisDelayed Serotonin Syndrome and Non-cardiogenic Pulmonary Edema Following Bupropion Overdose in a Seven-Year-Old Female: A Case Report and Review of Literature.
CureusTake It Easy! Serotonin Syndrome Precipitated by the Rapid Titration of Sertraline and Trazodone in the Setting of Risperidone Use.
Journal of pharmacy practiceSerious adverse drug events associated with psychotropic treatment of bipolar or schizoaffective disorder: a 17-year follow-up on the LiSIE retrospective cohort study.
Frontiers in psychiatrySerotonin syndrome presenting as acute dizziness with supine hypertension and orthostatic hypotension.
BMJ case reportsConcomitant treatment with safinamide and antidepressant drugs: Safety data from real clinical practice.
NeurologiaSerotonin syndrome treated with cyproheptadine using NPi from a digital pupillometer as a therapeutic indicator: A case report.
MedicineLinezolid Toxicity: A Clinical Case Report.
CureusSerotonin Syndrome and Dextromethorphan Toxicity Caused by Drug-Drug Interaction Between Fluoxetine and Bupropion-Dextromethorphan: A Case Report.
The Journal of clinical psychiatryTransient Fever Response After ECT in a Patient with Catatonic Schizophrenia: A Case Report.
Turk psikiyatri dergisi = Turkish journal of psychiatryBlack Cohosh Interactions with Prescription Medications Associated with Serotonin Toxicity and Rhabdomyolysis: A Case Report.
The Journal of emergency medicineAdministration of Intravenous Lipid Emulsion for Dextromethorphan Poisoning with Serotonin Syndrome: A Case Report.
Journal of personalized medicineTizanidine: Advances in Pharmacology & Therapeutics and Drug Formulations.
Journal of pain researchPotential Dextromethorphan-Induced Serotonin Syndrome Leading to Homicide and Suicide.
Academic forensic pathologyZopiclone-Induced Methemoglobinemia: A Case Report Highlighting How the Treatment Differs in Patients on Serotonergic Medication.
CureusMultiple Medication Use Resulting in Serotonin Syndrome With Deprescribing Resulting in Acute Dystonia.
Journal of clinical psychopharmacologySuccessful treatment of a severe 5-hydroxytrytophan intoxication using carbon hemoperfusion, hemodiafiltration, and mechanical ventilation in a dog.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)Serotonin syndrome: An often-neglected medical emergency.
Journal of family & community medicineSerotonin syndrome induced by amoxicillin-clavulanic acid.
NeurologiaSerotonin Syndrome and Catatonia in the Absence of a Serotonergic Agent Following Abrupt Withdrawal of Clozapine.
The Canadian journal of hospital pharmacySerotonin syndrome and neuroleptic malignant syndrome: A case report of intersecting symptomatology.
The mental health clinicianUnexpectedly Prolonged Serotonin Syndrome and Fatal Complications Following a Massive Overdose of Paroxetine Controlled-Release.
CureusSerotonin Syndrome With the Concomitant Use of Triptans and SSRIs/Serotonergic Medications: Is It Time to Revisit FDA Warning?
Journal of clinical psychopharmacologyRetrospective analysis of venlafaxine-induced hypoglycemia in patients with overdose.
Medicina clinicaKnowledge, Attitude, and Practice of Saudi Medical, Nursing, and Pharmacy Students and Interns Regarding Antidepressant Drugs and Drug-Induced Serotonin Syndrome.
CureusSerotonin Syndrome From the Complex Drug Interactions of Second-Generation Antipsychotics in Older Patients: Case Report and Literature Review.
American journal of therapeuticsConcurrent administration of serotonergic antidepressants and ozanimod in participants with relapsing multiple sclerosis from the open-label extension DAYBREAK trial.
Multiple sclerosis (Houndmills, Basingstoke, England)The Critical Role of Lambda-Shaped QRS-ST-T Wave Fusion ST-Elevation in Diagnosing and Managing Takotsubo Cardiomyopathy: A Case Report and Review of Literature.
CureusClonus, Hyperreflexia, and Hypertension: Serotonin Syndrome or Preeclampsia?
Journal of the Academy of Consultation-Liaison PsychiatrySerotonin syndrome and cannabis: A case report.
Australasian psychiatry : bulletin of Royal Australian and New Zealand College of PsychiatristsSerotonergic Medication Error: A Case Report of Serotonin Syndrome.
CureusEvaluation of neuroleptic malignant syndrome induced by antipsychotic drugs using spontaneous reporting system.
HeliyonSerotonin syndrome: A pharmacovigilance comparative study of drugs affecting serotonin levels.
European journal of clinical pharmacologyPrevalence and Correlates of Serotonin Syndrome in Real-World Inpatients.
Journal of clinical psychopharmacologySerotonin Syndrome Triggered by an Interaction Between Opioid Analgesics and Cobicistat: A Challenging Diagnostic Case Report.
CureusChallenges in the Clinical Diagnosis of Lithium Toxicity: A Case Report.
CureusSerotonin Syndrome: An Emerging Reality in the Emergency Department.
CureusClinical and Laboratory Factors Related to Seizure and Serotonin Toxicity in Tramadol Intoxication: An Egyptian Study.
Clinical drug investigationThe Association of Serotonin Toxicity with Combination Linezolid-Serotonergic Agent Therapy: A Systematic Review and Meta-Analysis.
Pharmacy (Basel, Switzerland)Serotonin syndrome in the acute treatment landscape of migraine: the lasmiditan experience.
Frontiers in neurologySOX1 Antibody in a Patient With Serotonin Syndrome.
CureusDrug-drug interactions between COVID-19 drug therapies and antidepressants.
Expert opinion on drug metabolism & toxicologyFentanyl-Induced Serotonin Syndrome 5 Days After Cessation of Serotonergic Agents: A Case Report.
A&A practiceA suspected case of serotonin syndrome induced by palonosetron and ramosetron administration.
Journal of exercise rehabilitationA Case Series of 11 Patients With Subacute Serotonin Syndrome.
Journal of the Academy of Consultation-Liaison PsychiatryThe G protein biased serotonin 5-HT2A receptor agonist lisuride exerts anti-depressant drug-like activities in mice.
Frontiers in molecular biosciencesCough elixir overdose causing toxic leuco-encephalopathy and serotonin syndrome.
Tropical doctorSerotonin syndrome caused by a CYP2C19-mediated interaction between low-dose escitalopram and clopidogrel: a case report.
Frontiers in psychiatryAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Serotonin syndrome presenting as severe reversible cerebral vasoconstriction syndrome.
- The effect of fentanyl combined with linezolid on in-hospital mortality in mechanically ventilated patients: A retrospective cohort study.
- Comment on "Selective Serotonin Reuptake Inhibitors and Risk of Serotonin Syndrome as a Consequence of Drug-Drug Interactions".Medical principles and practice : international journal of the Kuwait University, Health Science Centre· 2026· PMID 41632745mais citado
- Chronic tramadol abuse as a cause of serotonin syndrome.
- The interplay between serotonin syndrome and syndrome of inappropriate antidiuresis: a fatal case of acute hyponatremia during treatment with duloxetine, chlorphenamine, amitriptyline, and L-tryptophan.
- Anticholinergic burden in fibromyalgia treatment analysis: Guidelines adherence and pharmacological alerts.
- Case Report: Pharmacogenetically-triggered fatal serotonin syndrome following sequential serotonergic therapy in Parkinson's disease: a case highlighting the role of CYP2D6*10/*10 genotype and multifactorial drug interactions.
- Serotonin syndrome risk with concomitant opioid and serotonergic antidepressant use: a multinational pharmacovigilance study.
- Uveal Effusion and Exudative Macular Detachment Secondary to SSRI and Dexamphetamine Overdose.
- Efficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative Action: A Review of Clinical Data and Toxicological Risks.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:43116(Orphanet)
- MONDO:0018546(MONDO)
- GARD:18828(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
- Q616181(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar