Raras
Buscar doenças, sintomas, genes...
Síndrome da serotonina
ORPHA:43116CID-10 · T43.1CID-11 · 8D85DOENÇA RARA

A Síndrome Serotoninérgica é caracterizada por um excesso de serotonina no cérebro e na medula espinhal, geralmente associada ao uso de diversos medicamentos, incluindo os antidepressivos da classe dos ISRSs (inibidores seletivos de recaptação de serotonina).

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Introdução

O que você precisa saber de cara

📋

A Síndrome Serotoninérgica é caracterizada por um excesso de serotonina no cérebro e na medula espinhal, geralmente associada ao uso de diversos medicamentos, incluindo os antidepressivos da classe dos ISRSs (inibidores seletivos de recaptação de serotonina).

Publicações científicas
1.684 artigos
Último publicado: 2026 Apr 15

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
Unknown
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Início
All ages
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: T43.1
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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🧠
Neurológico
5 sintomas
🫃
Digestivo
3 sintomas
💪
Músculos
2 sintomas
❤️
Coração
2 sintomas
🫘
Rins
1 sintomas
👁️
Olhos
1 sintomas

+ 20 sintomas em outras categorias

Características mais comuns

90%prev.
Anormalidade do sistema nervoso autônomo
Muito frequente (99-80%)
55%prev.
Deterioração mental
Frequente (79-30%)
55%prev.
Náusea
Frequente (79-30%)
55%prev.
Irritabilidade
Frequente (79-30%)
55%prev.
Insônia
Frequente (79-30%)
55%prev.
Inquietação
Frequente (79-30%)
34sintomas
Muito frequente (1)
Frequente (11)
Ocasional (11)
Muito raro (11)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 34 características clínicas mais associadas, ordenadas por frequência.

Anormalidade do sistema nervoso autônomoAbnormality of the autonomic nervous system
Muito frequente (99-80%)90%
Deterioração mentalMental deterioration
Frequente (79-30%)55%
NáuseaNausea
Frequente (79-30%)55%
IrritabilidadeIrritability
Frequente (79-30%)55%
InsôniaInsomnia
Frequente (79-30%)55%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico1.684PubMed
Últimos 10 anos200publicações
Pico202590 papers
Linha do tempo
2026Hoje · 2026🧪 1992Primeiro ensaio clínico📈 2025Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

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Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
3Fase 31
2Fase 21
·Pré-clínico1
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 3 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Síndrome da serotonina

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Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

Pesquisa e ensaios clínicos

39 ensaios clínicos encontrados.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
751 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 751

#1

Serotonin syndrome presenting as severe reversible cerebral vasoconstriction syndrome.

Practical neurology2026 Feb 13

Serotonin syndrome is a life-threatening adverse drug reaction caused by excessive serotonergic activity from therapeutic use, overdose or drug interactions. Its recognition is challenging, as manifestations range from subtle to severe and fatal. Key diagnostic features are autonomic dysfunction, motor hyperactivity and exaggerated reflexes, including clonus. We report a young woman with severe serotonin syndrome due to serotonergic polypharmacy who developed reversible cerebral vasoconstriction syndrome and overlapping posterior reversible encephalopathy syndrome. The diagnosis was initially delayed because attention had focused on her prominent vascular features with severe focal neurological deficits rather than the underlying toxidrome. We diagnosed serotonin syndrome as she developed more characteristic features. This case highlights the importance of considering serotonin syndrome in patients receiving serotonergic medications who develop motor findings, autonomic dysfunction or unexplained neurological deterioration.

#2

The effect of fentanyl combined with linezolid on in-hospital mortality in mechanically ventilated patients: A retrospective cohort study.

PloS one2026

The combination of linezolid and opioid drugs such as fentanyl may increase the risk of serotonin syndrome, but its impact on in-hospital mortality is not yet clear. The aim of this study is to investigate the effect of simultaneous use of fentanyl and linezolid on in-hospital mortality in mechanically ventilated patients. Based on the MIMIC-IV database, 3339 patients receiving mechanical ventilation were enrolled and divided into three groups: the group receiving linezolid simultaneously (n = 43), the group receiving linezolid within 14 days (n = 22) and the group that did not use linezolid (n = 3274). Use multivariate Cox regression analysis to analyze in-hospital mortality rates and adjust for confounding factors. The in-hospital mortality rate of the group receiving linezolid simultaneously was 37.2% (16/43), the group receiving linezolid within 14 days was 40.9% (9/22), and the group that did not use linezolid was 22.9% (751/3274). The in-hospital mortality rate of the group receiving linezolid simultaneously was significantly higher than that of the group that did not use linezolid (hazard ratio [HR], 1.56; 95% CI, 1 ~ 2.43; P = 0.049). There was no statistically significant difference in in-hospital mortality rate among the group receiving linezolid within 14 days and the group that did not use linezolid (hazard ratio [HR], 1.01; 95% CI, 0.5 ~ 2.05; P = 0.968). Subgroup analysis showed that there was no interaction between different groups at baseline (age, gender, race, BMI, liver disease, and kidney disease) (interaction p-value > 0.05). In this post-hoc analysis, we found an association between the combined use of fentanyl and linezolid and increased in-hospital mortality among mechanically ventilated patients. However, this finding is based on studies with small sample sizes and requires further validation through larger, multicenter investigations. In clinical practice, the potential risks of this drug interaction should be carefully evaluated.

#3

Comment on "Selective Serotonin Reuptake Inhibitors and Risk of Serotonin Syndrome as a Consequence of Drug-Drug Interactions".

Medical principles and practice : international journal of the Kuwait University, Health Science Centre2026 Feb 03
#4

Chronic tramadol abuse as a cause of serotonin syndrome.

Toxicology reports2026 Jun

Serotonin syndrome is characterized by autonomic hyperactivity, altered mental status, and neuromuscular abnormalities, ranging from mild to life-threatening manifestations. Tramadol has been associated with serotonin syndrome, predominantly in combination with other serotonergic agents or following acute overdose. Reports describing serotonin syndrome caused by chronic high-dose tramadol use as a single serotonergic agent are scarce. A case of serotonin syndrome in a young adult with chronic high-dose tramadol dependence in the absence of co-ingested serotonergic drugs is presented. A 22-year-old man with tramadol dependence (800 mg daily) presented to the emergency department with anxiety and agitation. Physical examination revealed diaphoresis, mydriasis, tachycardia (130 beats/min), hypertension (140/100 mmHg), hyperreflexia, and inducible ankle clonus. Laboratory investigations, head computed tomography, and urine toxicology screening were unremarkable. Based on the presence of inducible clonus and hyperreflexia in the setting of serotonergic exposure, the Hunter Serotonin Toxicity Criteria were fulfilled. Tramadol was discontinued and replaced with methadone. The patient recovered completely within 48 h. This case illustrates that chronic high-dose tramadol use alone may precipitate serotonin syndrome. Clinicians should remain alert to this potentially life-threatening complication, even in the absence of concomitant serotonergic medication.

#5

The interplay between serotonin syndrome and syndrome of inappropriate antidiuresis: a fatal case of acute hyponatremia during treatment with duloxetine, chlorphenamine, amitriptyline, and L-tryptophan.

Therapeutic advances in psychopharmacology2026

Serotonin syndrome (SS) and hyponatremia are severe, potentially life-threatening adverse reactions to serotonergic medications. Their concurrent manifestation is rare but clinically significant due to overlapping pathophysiological mechanisms. This report describes the fatal outcome of a 30-year-old female who presented to the Emergency Department with agitation following self-administration of duloxetine 60 mg, in addition to ongoing amitriptyline therapy and possible L-tryptophan supplementation. During hospitalization, she was treated with intravenous chlorphenamine for a suspected allergic reaction. Subsequently, she developed severe neurological deterioration, malignant arrhythmia, and profound acute hyponatremia (serum sodium 114 mmol/L), culminating in brain death within 48 h. The synergistic pharmacodynamic and pharmacokinetic interactions between duloxetine, amitriptyline, and chlorphenamine-three agents with serotonin reuptake inhibition properties-were implicated in precipitating SS and syndrome of inappropriate antidiuresis (SIAD)-induced hyponatremia. This combination resulted in extensive cerebral edema and cardiopulmonary arrest. The case highlights the diagnostic challenge posed by overlapping SS and hyponatremia manifestations, particularly when compounded by incomplete pharmacological histories and inappropriate drug administration. Clinicians should maintain high vigilance for SS and hyponatremia in patients receiving serotonergic agents, especially when multiple such drugs are co-administered. Comprehensive medication anamnesis, prompt electrolyte monitoring, and avoidance of pharmacodynamic duplication are essential to prevent similar outcomes.

Publicações recentes

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📚 EuropePMC989 artigos no totalmostrando 194

2026

Chronic tramadol abuse as a cause of serotonin syndrome.

Toxicology reports
2026

The interplay between serotonin syndrome and syndrome of inappropriate antidiuresis: a fatal case of acute hyponatremia during treatment with duloxetine, chlorphenamine, amitriptyline, and L-tryptophan.

Therapeutic advances in psychopharmacology
2026

Severe 3,4-Methylenedioxymethamphetamine (MDMA)-Associated Rhabdomyolysis in Crohn's Disease: Direct Toxicity and Inflammatory Susceptibility in the Absence of Hyperthermia.

Cureus
2026

Serotonin syndrome presenting as severe reversible cerebral vasoconstriction syndrome.

Practical neurology
2026

Cocaine-Induced Rhabdomyolysis With Acute Kidney Injury in the Absence of Serotonin Syndrome: A Case Report.

Cureus
2026

Sertraline and quetiapine induced Serotonin Syndrome and Neuroleptic Malignant Syndrome: a case report.

BMC psychiatry
2026

Safety Concerns, Mechanistic Pathways, and Knowledge Gaps in the Clinical Use of Selective Serotonin Reuptake Inhibitors.

Cureus
2026

Survival Following a Tricyclic Antidepressant Overdose Presenting With Serotonin Syndrome-Like Symptoms and Critical Illness Polyneuropathy: A Case Report.

Cureus
2026

Adverse events related to buspirone: a real-world pharmacovigilance study using the FAERS database.

Journal of affective disorders
2026

Question: How Is it Possible That Phenelzine Combined With Dextromethorphan Could Cause Serotonin Syndrome?

Journal of clinical psychopharmacology
2026

The effect of fentanyl combined with linezolid on in-hospital mortality in mechanically ventilated patients: A retrospective cohort study.

PloS one
2026

Methylene Blue and Serotonin Syndrome: A Caution Against Intravenous Use.

Urogynecology (Philadelphia, Pa.)
2026

Triggers of highly lethal seizures induced by novel stimulants: A systematic review focused on synthetic cathinones and phenethylamines.

Neurotoxicology
2024

Venlafaxine-induced serotonin syndrome causing bilateral cerebral strokes: a case report.

Frontiers in stroke
2026

Cross-national differences in methylphenidate utilization in primarily adult psychiatric inpatients.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
2026

The evolving serotonin syndrome spectrum: from acute syndrome to smoldering presentations and personalized risk management.

Expert opinion on drug metabolism &amp; toxicology
2025

Serotonin Syndrome Versus Neuroleptic Malignant Syndrome in a Pediatric Patient Receiving Fluoxetine and Haloperidol: A Case Report.

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
2025

Knowledge, attitudes, and practices toward linezolid-serotonergic drug interactions: a cross-sectional study.

Frontiers in pharmacology
2025

Serotonin Syndrome With Quetiapine, Rizatriptan, Gabapentin, and Propranolol.

The primary care companion for CNS disorders
2025

Carisoprodol poisoning with serotonin toxicity.

BMJ case reports
2025

Time Course of Serum Dextromethorphan Concentrations in a Case of Serotonin Syndrome After Massive Overdose.

The American journal of case reports
2025

Serotonin syndrome induced by Bromfed DM in a patient on sertraline.

SAGE open medical case reports
2025

Evaluation of clinical findings in predicting the development of serotonin syndrome: can the Hunter's criteria be used in children?

Postgraduate medicine
2025

When Parkinson's disease encounters high fever: two case reports and literature review.

American journal of translational research
2025

Serotonin syndrome: understanding pathophysiological bases and managing a growing clinical challenge.

Neurologia i neurochirurgia polska
2026

Real-world pharmacovigilance and clinical risks of fluvoxamine: A disproportionality analysis based on FAERS data.

Journal of affective disorders
2025

Drug-associated serotonin syndrome in elderly patients: a comprehensive disproportionality analysis based on the FAERS database.

Frontiers in pharmacology
2025

Delayed Serotonin Syndrome Following the Concurrent Use of an Unregulated Supplement and Selective Serotonin Reuptake Inhibitors (SSRIs): A Case Report.

Cureus
2025

Anesthetic implications of psychotropic medications: a narrative review.

Journal of Yeungnam medical science
2025

Identifying Early Presentation of Serotonin Syndrome in a 20-Year-Old Man Prescribed Clomipramine and Quetiapine: A Case Report.

Cureus
2025

Fatal outcome of severe serotonin syndrome and acute respiratory distress syndrome after self-poisoning with paroxetine: a case report.

Journal of medical case reports
2025

A Real-World Pharmacovigilance study of FAERS Database for Fluvoxamine: Perspectives from Physicians and Pharmacists.

Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
2025

Polypharmacy-induced serotonin syndrome revealing underlying neurocognitive impairment and cervical myelopathy.

BMJ case reports
2025

Exploring drug interactions between newer antidepressants and medications used to treat neurological disorders.

Expert opinion on drug metabolism &amp; toxicology
2025

Intracranial Pressure-Guided Therapy in 3,4-Methylenedioxymethamphetamine (MDMA)-Induced Cerebral Edema: A Case Report.

Cureus
2025

Trauma-induced Catatonia in Pediatric Patients: Case Series and Literature Review.

Journal of child &amp; adolescent trauma
2025

Three Distinct Neuropsychiatric Syndromes Following Pineal Teratoma Resection.

Journal of child and adolescent psychopharmacology
2025

A Narrative Review on Toxidromes in the Psychiatric Population: Implications for Overdose Prevention.

Journal of clinical medicine
2025

Concomitant use of antidepressants and classic psychedelics: A scoping review.

Journal of psychopharmacology (Oxford, England)
2025

Discordance in Drug-Drug Interaction Alerts for Antidotes: Comparative Analysis of Electronic Databases and Interpretive Insights from AI Tools.

Drug design, development and therapy
2025

Neuroleptic Malignant Syndrome in an Institutionalized Geriatric Patient Following Antipsychotic Switch to Quetiapine: A Fatal Outcome.

Cureus
2025

Serotonin Syndrome Masquerading as Alcohol Withdrawal: A Case Report.

Journal of addictive diseases
2025

The Overlap of Posterior Reversible Encephalopathy Syndrome and Reversible Cerebral Vasoconstriction Syndrome: A Report of a Complex Case and Challenges With Its Management.

Cureus
2025

Serotonin syndrome following spinal anaesthesia for elective caesarean delivery: a case report.

International journal of obstetric anesthesia
2025

An Analytic Review of Neuropsychiatric Syndromes in the Intensive Care Unit.

Journal of intensive care medicine
2025

Neurological adverse events associated with antidepressants: a comprehensive 22-year analysis of the FDA adverse event reporting system.

Frontiers in pharmacology
2025

Safety of antidepressants commonly used in 6-17-year-old children and adolescents: A disproportionality analysis from 2014-2023 on the basis of the FAERS database.

PloS one
2025

A practical approach to managing agitated toxidromes.

Tropical doctor
2025

Investigation into the Effects of Tramadol, Citalopram, Tianeptine, and Their Combinations on Rat Brain Tissue.

Biomedicines
2025

Generalized Myoclonus in an Elderly Patient on Risperidone: A Rare but Important Adverse Effect.

Case reports in psychiatry
2025

MAO inhibitors for treatment-resistant depression: Bringing an updated perspective on pioneering drugs.

Pharmacological research
2025

Serotonin Syndrome Without Overdose: Polypharmacy-Induced Toxicity in a Medically Stable Young Adult.

Cureus
2025

Linezolid in combination with pentazocine causes serotonin syndrome: A case report.

Medicine
2025

A case of serotonin syndrome following the reintroduction of aripiprazole after dextromethorphan overdose.

PCN reports : psychiatry and clinical neurosciences
2025

Fatalities following DMT use: two case reports and a review of the literature.

Journal of analytical toxicology
2025

The Effect of Antibiotics on the Nervous System: Importance for Anesthesiology and Intensive Care.

Antibiotics (Basel, Switzerland)
2025

Posterior Reversible Encephalopathy Syndrome Induced by Mirtazapine Overdose: A Case Report.

Case reports in neurological medicine
2025

A case of bupropion overdose: Bupropion intoxication and/or serotonin syndrome?

Psychiatria Danubina
2025

Prolonged Serotonergic Symptoms in a Pediatric Patient: Suspected Interaction Between Prescription Medications and Kava Supplement.

Cureus
2026

From Theory to Therapy: Methylene Blue's Emerging Role in the Management of Septic Shock.

Journal of pharmacy practice
2025

Disproportionality analysis of serotonin syndrome associated with selective serotonin reuptake inhibitors: a pharmacovigilance analysis.

European journal of clinical pharmacology
2025

Definitive urine drug testing in emergency medicine: Recreational and psychiatric drug findings.

Journal of mass spectrometry and advances in the clinical lab
2025

Case Report: Neuroleptic malignant syndrome in a 15-year-old female following of psychotropic drugs.

Frontiers in psychiatry
2025

Risk Assessment of Linezolid-Associated Neurological Adverse Drug Reactions Based on the Food and Drug Administration Adverse Event Reporting System Database.

Journal of multidisciplinary healthcare
2025

Adverse events associated with four atypical antipsychotics used as augmentation treatment for major depressive disorder: A pharmacovigilance study based on the FAERS database.

Journal of affective disorders
2025

Acute Febrile Encephalopathy with Rigidity.

Journal of intensive care medicine
2025

Postoperative Serotonin Syndrome Triggered by Propofol in a Patient on Chronic Serotonergic Medications and Bupropion: A Case Report.

Cureus
2025

Development and Validation of an Approach to Assessing Clinical Relevance of Potential Drug-Drug Interactions Inducing Rare but Serious Adverse Events.

Clinical and translational science
2025

Isoniazid-Associated Serotonin Toxicity in the Critical Care Setting: A Case Report.

Cureus
2025

Catatonia: American Psychiatric Association Resource Document.

Journal of the Academy of Consultation-Liaison Psychiatry
2025

Single-Substance SSRI Intoxication: A Clinical and Outcome Profile Presentation in a Poisoning Referal Center.

Emergency medicine international
2025

Opsoclonus-Myoclonus: Not Always Paraneoplastic.

Movement disorders clinical practice
2025

A Translational Model-Based Meta-Analysis to Predict Tremor Incidence Associated with Serotonin Reuptake Transporter Inhibition.

Clinical pharmacology and therapeutics
2025

Selective Serotonin Reuptake Inhibitors and Risk of Serotonin Syndrome as Consequence of Drug-Drug Interactions: Analysis of the FDA Adverse Event Reporting System.

Medical principles and practice : international journal of the Kuwait University, Health Science Centre
2025

Prevalence of Serotonergic Drug Use in Patients Exposed to Perioperative Methylene Blue: A Cross-Sectional Study.

Cureus
2025

Serotonin syndrome induced through a combination of oxycodone and amitriptyline: A case report.

Psychiatry and clinical neurosciences
2025

Serotonin syndrome as a cause of delirium.

BMJ supportive &amp; palliative care
2025

Antidepressant and antiobesity drug-induced serotonin syndrome complicated by multiple organ injury: A case report.

Medicine
2025

Rhabdomyolysis and Acute Kidney Injury: Exploring the Potential Causes in a Hospitalized Patient.

Cureus
2025

Combinations of compound cold medicines should be used with caution: a case series.

Frontiers in medicine
2025

Clinical effects of acute lamotrigine overdose (ATOM-10).

Clinical toxicology (Philadelphia, Pa.)
2025

Postoperative Serotonin Syndrome: A Case Report Highlighting Dexmedetomidine for Refractory Symptoms.

Cureus
2025

A fatal intoxication case due to the serotonin syndrome induced by dextromethorphan and moclobemide overdose.

Legal medicine (Tokyo, Japan)
2025

Serotonin Syndrome Associated With High-dose Diphenhydramine Use Complicating Abdominoplasty and Mastopexy.

Plastic and reconstructive surgery. Global open
2025

Anaesthetic implications of psilocybin and lysergic acid diethylamide: what is old is now new: A narrative review on psychedelics and anaesthesia.

European journal of anaesthesiology
2025

Tramadol and mental health: A systematic review of case reports describing psychological side-effects.

International journal of psychiatry in medicine
2025

Linezolid and serotonin syndrome.

The Journal of international medical research
2025

Noticeable changes in diaphoresis severity following pain management medication adjustments in a complex regional pain syndrome patient.

Anesthesia and pain medicine
2025

Linezolid and tedizolid adverse effects: a review on serotonin syndrome, myelosuppression, neuropathies, and lactic acidosis.

Antimicrobial stewardship &amp; healthcare epidemiology : ASHE
2025

Serotonin Syndrome With Concomitant Antidepressant and Tramadol: A Case Report.

Cureus
2025

Mitigative and neuroprotective effects of Lavandula angustifolia essential oil on serotonin syndrome-induced neurotoxicity in male albino rats.

Drug and chemical toxicology
2025

Concomitant Use of Etrasimod With Opioids or Antidepressants in Patients With Ulcerative Colitis-A Safety Analysis.

United European gastroenterology journal
2025

Preparation and pharmacokinetic evaluation of a sertraline-methylpropyphenazone prodrug: a comparative metabolic study on the plasma and brain tissues of rats using LC-MS/MS analysis.

RSC advances
2025

Comparison of clinicodemographic characteristics in patients with selective serotonin reuptake inhibitors poisoning: A cross-sectional study.

Medical journal, Armed Forces India
2025

Evaluating the risk of mild serotonin syndrome in primary care: a retrospective case series of patients with treatment-resistant depression.

AME case reports
2025

Drug-Induced Myoclonus: A Systematic Review.

Medicina (Kaunas, Lithuania)
2024

Challenges in the Management of Severe Serotonin Syndrome: A Case Report.

Cureus
2025

The impact of borneolum on Citalopram hydrobromide pharmacokinetics and serotonin levels in the hypothalamus of conscious rats.

Natural product research
2025

Review article: Efficacy of cyproheptadine in the management of serotonin toxicity following deliberate self-poisoning - A systematic review.

Emergency medicine Australasia : EMA
2024

Neurological Insights: Transient Unilateral Relative Afferent Pupillary Defect in the Context of Serotonin Syndrome.

Cureus
2025

Contemporary Perspectives in Critical Care of Neuroleptic Malignant Syndrome.

Neurocritical care
2025

An Older Man with Clonus, Rigidity, Hyperreflexia, and Hand Tremors.

Journal of pain &amp; palliative care pharmacotherapy
2024

Serotonin Syndrome in Parkinson's Disease: Don't Get It Confused by a Tremor.

Cureus
2024

Investigation of Pharmacokinetic and Pharmacodynamic Interactions between Citalopram and Duloxetine: An Integrated Analytical, Computational, Behavioral, and Biochemical Approach.

ACS pharmacology &amp; translational science
2025

Chronic Serotonin Syndrome Masquerading as Anxiety and Agitation in a Patient With Mood Disorder: A Clinical Dilemma!

Bipolar disorders
2024

Serotonin Syndrome with Propofol and Remifentanil: Mechanistic Concern and Alternative Diagnosis.

A&amp;A practice
2024

Delayed diagnosis of basilar artery occlusion in a 28-year-old postpartum woman.

BMC neurology
2024

Structural Conversion of Serotonin into Amyloid-like Nanoassemblies Conceptualizes an Unexplored Neurotoxicity Risk.

ACS nano
2024

LARGE-SCALE BRAIN NETWORKS IN CHRONIC AND SMOLDERING SEROTONIN SYNDROME.

Psychiatria Danubina
2024

[Serotonin syndrome secondary to the association of paroxetine and amitriptyline: a case report].

The Pan African medical journal
2024

Management of Suspected α-Pyrrolidinoisohexanophenone (α-PiHP)-Related Hyperthermia in a Young Adult: A Case Report.

Cureus
2025

Medication-overuse headache overlapping with serotonin syndrome.

Drug and therapeutics bulletin
2024

Bipolar Disorder in a Young Adult With Thalassemia Major With Sequential Development of Neuroleptic Malignant Syndrome and Serotonin Syndrome.

Journal of clinical psychopharmacology
2024

Recognizing serotonin syndrome in the intensive care unit: a case report of serotonin syndrome in a patient taking amitriptyline, buprenorphine, pregabalin, and fentanyl.

AME case reports
2024

Psychiatric Etiologies and Approaches in Altered Mental Status Presentations: Insights from Consultation Liaison Psychiatry.

Seminars in neurology
2024

A False-positive Diagnosis of a Lethal Serotonin Syndrome Based on Postmortem Whole-blood Levels of Sertraline: How Forensic Detective Work Uses Medical Knowledge and Clinical Pharmacology to Solve Cases.

Journal of psychiatric practice
2024

Cyproheptadine is preferable to benzodiazepines in mild cases of serotonin syndrome (toxicity).

British journal of clinical pharmacology
2024

Advising patients on serotonin syndrome in General Practice.

British journal of clinical pharmacology
2024

Serotonin syndrome caused by escitalopram in Parkinson's disease psychosis: a case report.

BMC geriatrics
2024

Incidence of serotonin syndrome in patients receiving tedizolid and concomitant serotonergic agents.

Antimicrobial agents and chemotherapy
2024

An Unexpected Presentation of Serotonin Syndrome in a Patient Receiving ECT.

Case reports in psychiatry
2024

Predictors of Serotonin Syndrome in Acute Poisoning with 5-Hydroxytryptamine Modulators.

Toxics
2024

Serotonin syndrome: A rare yet crucial diagnosis.

JAAPA : official journal of the American Academy of Physician Assistants
2024

Serotonin Syndrome Induced by Fentanyl Alone in an Adult Patient After Cardiac Surgery: A Case Report.

Cureus
2024

Bronchial carcinoid: a neuroendocrine manifestation-presented as bronchospasm and hypertension during resection.

Indian journal of thoracic and cardiovascular surgery
2024

Analytically Confirmed Intentional Overdose of the Antidepressant Vortioxetine.

Journal of medical toxicology : official journal of the American College of Medical Toxicology
2024

Prevalence of contraindicated combinations amid behavioral and mental health medications filled in a pediatric population.

BMC primary care
2024

A Case study of polypharmacy-induced serotonin syndrome in a cancer patient.

Journal of the American Association of Nurse Practitioners
2024

Acute clomipramine exposure elicits dose-dependent surfacing behavior in adult zebrafish (Danio rerio).

PeerJ
2025

Concomitant Administration of Ozanimod and Serotonergic Antidepressants in Patients With Ulcerative Colitis or Relapsing Multiple Sclerosis.

Inflammatory bowel diseases
2024

Analgesic treatment for refractory cancer pain caused by gastric cancer bone metastasis: A case report and literature review.

Medicine
2024

Serotonin Syndrome-Mimicking Manifestations in a Patient with Systemic Lupus Erythematosus.

Journal of clinical medicine
2024

Serotonin syndrome controversies: A need for consensus.

World journal of critical care medicine
2025

Hypertensive Crisis Associated with Serotonin Syndrome Following Linezolid Administration: Report of Two Cases.

Current drug safety
2024

Serotonin Syndrome After Prolonged Remifentanil and Propofol Infusion for Craniotomy: A Case Report.

A&amp;A practice
2024

Idiopathic Serotonin Syndrome - Does It Exist?

Annals of Indian Academy of Neurology
2024

Caution for psychiatrists: malignant hyperthermia risks with the anesthetic agent succinylcholine (Suxamethonium) during electroconvulsive therapy.

BMC psychiatry
2024

Cyproheptadine in serotonin syndrome: A retrospective study.

Journal of family medicine and primary care
2024

Neuroleptic malignant syndrome and serotonin syndrome: a comparative bibliometric analysis.

Orphanet journal of rare diseases
2024

Recurrent Serotonin Syndrome After Ketamine-assisted Electroconvulsive Therapy: A Case Report and Review of the Literature.

Journal of psychiatric practice
2024

Post-marketing safety concerns with lumateperone: a pharmacovigilance analysis based on the FDA adverse event reporting system (FAERS) database.

Frontiers in pharmacology
2024

Off-label higher doses of serotonin reuptake inhibitors in the treatment of obsessive-compulsive disorder: Safety and tolerability.

Comprehensive psychiatry
2024

Altered Mental Status in an Octogenarian: How Frequently Should Serotonin Syndrome Be Considered?

Cureus
2024

Haloperidol-Induced Neuroleptic Malignant Syndrome: A Case Report.

Cureus
2024

Adverse reactions caused by high serum concentration of linezolid: Two case reports and literature review.

Clinical case reports
2025

From Evidence to Practice: A Comprehensive Analysis of Side Effects in Synthetic Anti-Depressant Therapy.

Current drug safety
2024

A fatal case of desvenlafaxine and paroxetine poisoning.

Journal of pharmaceutical and biomedical analysis
2024

Delayed Serotonin Syndrome and Non-cardiogenic Pulmonary Edema Following Bupropion Overdose in a Seven-Year-Old Female: A Case Report and Review of Literature.

Cureus
2024

Take It Easy! Serotonin Syndrome Precipitated by the Rapid Titration of Sertraline and Trazodone in the Setting of Risperidone Use.

Journal of pharmacy practice
2024

Serious adverse drug events associated with psychotropic treatment of bipolar or schizoaffective disorder: a 17-year follow-up on the LiSIE retrospective cohort study.

Frontiers in psychiatry
2024

Serotonin syndrome presenting as acute dizziness with supine hypertension and orthostatic hypotension.

BMJ case reports
2024

Concomitant treatment with safinamide and antidepressant drugs: Safety data from real clinical practice.

Neurologia
2024

Serotonin syndrome treated with cyproheptadine using NPi from a digital pupillometer as a therapeutic indicator: A case report.

Medicine
2024

Linezolid Toxicity: A Clinical Case Report.

Cureus
2024

Serotonin Syndrome and Dextromethorphan Toxicity Caused by Drug-Drug Interaction Between Fluoxetine and Bupropion-Dextromethorphan: A Case Report.

The Journal of clinical psychiatry
2024

Transient Fever Response After ECT in a Patient with Catatonic Schizophrenia: A Case Report.

Turk psikiyatri dergisi = Turkish journal of psychiatry
2024

Black Cohosh Interactions with Prescription Medications Associated with Serotonin Toxicity and Rhabdomyolysis: A Case Report.

The Journal of emergency medicine
2024

Administration of Intravenous Lipid Emulsion for Dextromethorphan Poisoning with Serotonin Syndrome: A Case Report.

Journal of personalized medicine
2024

Tizanidine: Advances in Pharmacology & Therapeutics and Drug Formulations.

Journal of pain research
2024

Potential Dextromethorphan-Induced Serotonin Syndrome Leading to Homicide and Suicide.

Academic forensic pathology
2024

Zopiclone-Induced Methemoglobinemia: A Case Report Highlighting How the Treatment Differs in Patients on Serotonergic Medication.

Cureus
2024

Multiple Medication Use Resulting in Serotonin Syndrome With Deprescribing Resulting in Acute Dystonia.

Journal of clinical psychopharmacology
2024

Successful treatment of a severe 5-hydroxytrytophan intoxication using carbon hemoperfusion, hemodiafiltration, and mechanical ventilation in a dog.

Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)
2024

Serotonin syndrome: An often-neglected medical emergency.

Journal of family &amp; community medicine
2024

Serotonin syndrome induced by amoxicillin-clavulanic acid.

Neurologia
2024

Serotonin Syndrome and Catatonia in the Absence of a Serotonergic Agent Following Abrupt Withdrawal of Clozapine.

The Canadian journal of hospital pharmacy
2024

Serotonin syndrome and neuroleptic malignant syndrome: A case report of intersecting symptomatology.

The mental health clinician
2023

Unexpectedly Prolonged Serotonin Syndrome and Fatal Complications Following a Massive Overdose of Paroxetine Controlled-Release.

Cureus
2024

Serotonin Syndrome With the Concomitant Use of Triptans and SSRIs/Serotonergic Medications: Is It Time to Revisit FDA Warning?

Journal of clinical psychopharmacology
2024

Retrospective analysis of venlafaxine-induced hypoglycemia in patients with overdose.

Medicina clinica
2023

Knowledge, Attitude, and Practice of Saudi Medical, Nursing, and Pharmacy Students and Interns Regarding Antidepressant Drugs and Drug-Induced Serotonin Syndrome.

Cureus
2024

Serotonin Syndrome From the Complex Drug Interactions of Second-Generation Antipsychotics in Older Patients: Case Report and Literature Review.

American journal of therapeutics
2024

Concurrent administration of serotonergic antidepressants and ozanimod in participants with relapsing multiple sclerosis from the open-label extension DAYBREAK trial.

Multiple sclerosis (Houndmills, Basingstoke, England)
2023

The Critical Role of Lambda-Shaped QRS-ST-T Wave Fusion ST-Elevation in Diagnosing and Managing Takotsubo Cardiomyopathy: A Case Report and Review of Literature.

Cureus
2023

Clonus, Hyperreflexia, and Hypertension: Serotonin Syndrome or Preeclampsia?

Journal of the Academy of Consultation-Liaison Psychiatry
2024

Serotonin syndrome and cannabis: A case report.

Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists
2023

Serotonergic Medication Error: A Case Report of Serotonin Syndrome.

Cureus
2023

Evaluation of neuroleptic malignant syndrome induced by antipsychotic drugs using spontaneous reporting system.

Heliyon
2024

Serotonin syndrome: A pharmacovigilance comparative study of drugs affecting serotonin levels.

European journal of clinical pharmacology
2024

Prevalence and Correlates of Serotonin Syndrome in Real-World Inpatients.

Journal of clinical psychopharmacology
2023

Serotonin Syndrome Triggered by an Interaction Between Opioid Analgesics and Cobicistat: A Challenging Diagnostic Case Report.

Cureus
2023

Challenges in the Clinical Diagnosis of Lithium Toxicity: A Case Report.

Cureus
2023

Serotonin Syndrome: An Emerging Reality in the Emergency Department.

Cureus
2023

Clinical and Laboratory Factors Related to Seizure and Serotonin Toxicity in Tramadol Intoxication: An Egyptian Study.

Clinical drug investigation
2023

The Association of Serotonin Toxicity with Combination Linezolid-Serotonergic Agent Therapy: A Systematic Review and Meta-Analysis.

Pharmacy (Basel, Switzerland)
2023

Serotonin syndrome in the acute treatment landscape of migraine: the lasmiditan experience.

Frontiers in neurology
2023

SOX1 Antibody in a Patient With Serotonin Syndrome.

Cureus
2023

Drug-drug interactions between COVID-19 drug therapies and antidepressants.

Expert opinion on drug metabolism &amp; toxicology
2023

Fentanyl-Induced Serotonin Syndrome 5 Days After Cessation of Serotonergic Agents: A Case Report.

A&amp;A practice
2023

A suspected case of serotonin syndrome induced by palonosetron and ramosetron administration.

Journal of exercise rehabilitation
2024

A Case Series of 11 Patients With Subacute Serotonin Syndrome.

Journal of the Academy of Consultation-Liaison Psychiatry
2023

The G protein biased serotonin 5-HT2A receptor agonist lisuride exerts anti-depressant drug-like activities in mice.

Frontiers in molecular biosciences
2024

Cough elixir overdose causing toxic leuco-encephalopathy and serotonin syndrome.

Tropical doctor
2023

Serotonin syndrome caused by a CYP2C19-mediated interaction between low-dose escitalopram and clopidogrel: a case report.

Frontiers in psychiatry
Ver todos os 989 no EuropePMC

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Serotonin syndrome presenting as severe reversible cerebral vasoconstriction syndrome.
    Practical neurology· 2026· PMID 41690768mais citado
  2. The effect of fentanyl combined with linezolid on in-hospital mortality in mechanically ventilated patients: A retrospective cohort study.
    PloS one· 2026· PMID 41604401mais citado
  3. Comment on "Selective Serotonin Reuptake Inhibitors and Risk of Serotonin Syndrome as a Consequence of Drug-Drug Interactions".
    Medical principles and practice : international journal of the Kuwait University, Health Science Centre· 2026· PMID 41632745mais citado
  4. Chronic tramadol abuse as a cause of serotonin syndrome.
    Toxicology reports· 2026· PMID 41853658mais citado
  5. The interplay between serotonin syndrome and syndrome of inappropriate antidiuresis: a fatal case of acute hyponatremia during treatment with duloxetine, chlorphenamine, amitriptyline, and L-tryptophan.
    Therapeutic advances in psychopharmacology· 2026· PMID 41732713mais citado
  6. Anticholinergic burden in fibromyalgia treatment analysis: Guidelines adherence and pharmacological alerts.
    Clinics (Sao Paulo)· 2026· PMID 41990485recente
  7. Case Report: Pharmacogenetically-triggered fatal serotonin syndrome following sequential serotonergic therapy in Parkinson's disease: a case highlighting the role of CYP2D6*10/*10 genotype and multifactorial drug interactions.
    Front Psychiatry· 2026· PMID 41987814recente
  8. Serotonin syndrome risk with concomitant opioid and serotonergic antidepressant use: a multinational pharmacovigilance study.
    Front Pharmacol· 2026· PMID 41971097recente
  9. Uveal Effusion and Exudative Macular Detachment Secondary to SSRI and Dexamphetamine Overdose.
    Retin Cases Brief Rep· 2026· PMID 41944631recente
  10. Efficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative Action: A Review of Clinical Data and Toxicological Risks.
    Pharmaceuticals (Basel)· 2026· PMID 41901246recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:43116(Orphanet)
  2. MONDO:0018546(MONDO)
  3. GARD:18828(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Artigo Wikipedia(Wikipedia)
  6. Q616181(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Compêndio · Raras BR

Síndrome da serotonina

ORPHA:43116 · MONDO:0018546
Prevalência
Unknown
Herança
Not applicable
CID-10
T43.1 · Intoxicação por antidepressivos inibidores da monoaminooxidase (MAO)
CID-11
Início
All ages
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C0699828
EuropePMC
Wikidata
Wikipedia
Papers 10a
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