Respiratory syncytial virus - from discovery to vaccines.

The quality of life of parents of children with disabilities in Saudi Arabia: a systematic review.

Educational attainment among primary school children with neurodisability: a population-based cohort study using linked education and health data from England.

Neuropathological measures of increased tau phosphorylation across the Down syndrome lifespan.

Preoperative pulmonary hemodynamics and clinical decision making to determine operability and risk of long-term pulmonary hypertension in infants with open shunt under 1 year.

Combining blood biomarkers and the German version of the Dementia Screening Questionnaire for Individuals with Intellectual Disabilities (DSQIID-G) for diagnosing cognitive decline in Down syndrome.

Targeting lncRNA DSCAM-AS1 for disease diagnosis and therapy.

The evolving landscape of CAR T cell therapy in children and young adults with B cell acute lymphoblastic leukemia.

Complications of Adenotonsillectomy Surgery: Analysis of Pediatric Down Syndrome Patients in a Tertiary Center.

Soft Tissue Surgical Technique for Obligate Dislocation of the Patella.

First-Trimester Down Syndrome Screening in Renal-Transplanted Pregnant Women: Blood Creatinine Levels Impact False-Positive Rate.

Patterns, survival, and mortality predictors in children with down syndrome and congenital heart disease in resource-limited settings: a follow-up study.

Sucking Patterns in Infants with Down Syndrome admitted to a Level 4 Neonatal Intensive Care Unit.

Quantitative analysis of DNA-GATA1 binding alterations linked to hematopoietic disorders.

Measurement of Tau Protein and Aβ Amyloid Plaques in Postmortem Human Brains of Down Syndrome and Alzheimer's Disease by Using [125I]IPPI and [125I]IBETA Autoradiography.

Strengthening Undergraduate Medical Education for Inclusive Health Care for People With Down Syndrome and Intellectual and Developmental Disabilities in Medical Schools: Protocol for a Scoping Review.

Identification of autosomal and sex chromosome aneuploidies using next generation sequencing.

Positron emission tomography of neuroinflammation in Down syndrome and Alzheimer's disease: Current status and future perspectives.

The Amyloid Plaque Proteomes of Alzheimer's Disease and Mild Cognitive Impairment.

Increased dendritic inhibition of dentate gyrus granule cells in a mouse model of Down syndrome.

Evaluation of [18F]MK-6240 binding to tau protein in postmortem human brains of Down syndrome and Alzheimer's disease and assessment of off-target (non-tau) binding.

Definitive ileostomy in Total Colonic Aganglionosis: results and considerations from a single-center experience.

Selective chr21 homolog silencing reveals polymorphisms influence the epigenetic silencing and functional dosage of RWDD2B.

Dietary Patterns and Lifestyle Factors as Determinants of Body Mass Index and Body Composition in Individuals with Down Syndrome-A Study Across Three Clinical Sites.

The Effects of Physical Therapy in the Rehabilitation of Motor Delays in Children with Down Syndrome: A Systematic Review.

Biologically Younger Individuals, as Identified by MARK-AGE Biological Age Scores, Display a Distinct Favourable Blood Chemistry Profile Regardless of Age.

Transient Abnormal Myelopoiesis in a Non-Down Syndrome Infant With Subsequent Evolution to Acute Myeloid Leukemia.

Prophylactic Levofloxacin Use in Oncology and Hematopoietic Stem Cell Transplants for Children Under 2 Years of Age.

Predicting down syndrome: a comparative evaluation of nasal bone length in mid-trimester pregnancy.

Nail Disorders in Children With Down Syndrome: A Multicenter Study.

Pediatric SleepNet: A Deep Learning Network for Reliable Pediatric Sleep Staging Across Developmental Stages.

Tinea Capitis and Down Syndrome: A Multi-Center Retrospective Cohort Study.

Validation of the sibling acceptance questionnaire among typically-developing emerging adult siblings of individuals with disabilities.

A Comparative Effectiveness Study of Lorazepam or IVIg Versus no Treatment for Down Syndrome Regression Disorder.

High Metabolic Syndrome Prevalence in Down Syndrome Children: Need for New Guidelines.

Values of Individuals With Rare Genetic Neurodevelopmental Disorders and Their Family/Caregivers in Healthcare: A Scoping Review to Inform Guideline Development.

Immediate Effect of LED Cluster on Masticatory Muscles in Children and Adolescents Diagnosed With Down Syndrome: A Pilot Study.

Acute kidney injury and chronic kidney disease in individuals with Down syndrome: a nationwide cohort study.

Genetic analysis of triplicated genes affecting sex-specific skeletal deficits in Down syndrome model mice.

Nucleoli-localized KANSL2 as an epigenetic regulator of ribosome biogenesis in glioblastoma cells.

Familial Robertsonian Translocation, rob(14;21), with high risk for Down syndrome.

Electroconvulsive Therapy in a Patient With Down Syndrome Regression Disorder and Inspire Device: A Case Report.

When the Wires Cross Twice: A Case Report of the Perioperative Management of a Pediatric Patient With Both Abdominal Cardiac and Diaphragm Pacemakers.

A Newborn With Down-Klinefelter Syndrome and Bilateral Congenital Cataracts Harboring a Novel MAPKAPK3 Mutation.

Differences in upper airway endotype among phenotypically different pediatric OSA patients.

Obstructive Sleep Apnea-Hypopnea Syndrome in Children With Down Syndrome Treated at a Tertiary Care Hospital in Northeastern Colombia.

Formative evaluation of PREPARE for Autistic Adults: An adult autism training for resident physicians designed with autistic adults and family members.

Between care and collapse: the hidden health and emotional struggles of Saudi mothers of children with Down syndrome.

Spontaneous remission of congenital acute megakaryoblastic leukemia in a neonate with down syndrome.

Estimation of the number of people with Down syndrome in Latin America and the Caribbean.

Medicaid home and community based services are vital for adults with intellectual and developmental disabilities: A descriptive study of service use among all adult enrollees, 2022.

Prognostic Value of Leuko-glycemic Index as a Marker of Immediate Postoperative Events After Repair of Complete Atrioventricular Septal Defect in Infants With Down Syndrome.

Efficacy of bumetanide for cognitive improvement in children and adolescents with Down syndrome: study protocol of a randomised, double-blind, placebo-controlled trial.

Tongue strength and endurance in relation to oral cavity morphology among children with Down syndrome in the permanent dentition period.

A Population-Based Study of U.S. Trends in Selected Congenital Anomalies (2016-2023) and Socio-Demographic Disparities: A CDC WONDER Analysis.

Educational Attainment of Children With Major Congenital Anomalies During Primary School in England: A Population Cohort Study.

Neuroinflammation as a driver of Down syndrome-associated Alzheimer's disease.

Socio-Ecological Factors of Physical Activity in Children and Adolescents With Down Syndrome: A Mixed-Methods Systematic Review.

Establishment and characterization of induced pluripotent stem cell lines from individuals with Down syndrome and age-matched euploid donors.

Infants ≤24 weeks are not just smaller extremely preterm infants.

Adults with Down syndrome display altered entrainment of occipital cortical neurons.

Experiences and Preferences With Pediatric Health Supervision Care Among Family Caregivers of Individuals With Down Syndrome.

Multi-omics investigation of thyroid development and dysfunction in down syndrome.

Ophthalmic screening in down syndrome: A DSMIG UK Best practice recommendation (Revised 2025).

Detection, imaging and quantification of phosphoinositides using ion chromatography suppressed conductivity and mass spectrometry imaging.

[A woman with a very itchy rash].

The cholinergic system exerts opposing effects on memory at different stages of disease progression in Alzheimer's and Down syndrome model systems.

Long-term outcome in children with infantile epileptic spasms syndrome: a multicenter retrospective study in Korea.

Prosodic Imitation in Children With Down Syndrome: Evidence From Sentence Repetition and Pitch Contour Modeling.

Directed Teaching of Clinical Reasoning in the Fourth Year of Medical School: A Structured Summary of Genetic Observations.

Searching for New Possible Peripheral Biomarkers of Cognitive Decline in Down Syndrome: The Role of IL-18 Pathway and its Interaction with TGF-β1 and TNF-α.

Surveying immune and inflammatory alterations in periodontitis among individuals with Down syndrome: A preliminary cross-sectional study.

A Rare Dual Atresia Case Report Introducing Gastric Distension-Assisted Esophageal Approximation (GDEA): A Hypothetical Novel Technique for Long-Gap Esophageal Atresia.

Decoding Alzheimer's disease through down syndrome: insights from a genetically defined population.

Habilitative and rehabilitative educational interventions as protective factors against cognitive decline in adults with Down syndrome: A retrospective study.

Communicative Development Inventories (CDIs) in etiologically diverse developmental conditions: A systematic review.

Cognitive Predictors of Adaptive Behaviour in Children With Down Syndrome: A Systematic Review.

Up-regulation of Minibrain/DYRK1A contributes to macrocephaly and brain overgrowth in a Drosophila model of fragile X syndrome.

Factors impacting survival in individuals with Down syndrome-associated Alzheimer's disease.

Incidence and risk factors of respiratory events after tonsillectomy for obstructive sleep apnea in children with a preoperative indication of intensive care unit admission.

Parents' Experiences and Expectations From Physiotherapy for Children With Down Syndrome: A Scoping Review.

A rare intersection: Oral carcinoma cuniculatum in the context of Down syndrome.

Assessment of cognitive function in individuals with Down syndrome and dementia: a systematic review.

Loss of cystathionine-β-synthase contributes to elevated OXPHOS, a vulnerability in Ara-C-resistant Myeloid Leukemia in Down syndrome.

Spatial abilities in aging adults with Down syndrome.

Obstructive sleep apnea in adults with Down syndrome: body composition, metabolic profile and cognitive status.

Multi-level surgery for obstructive sleep apnoea in syndromic and non-syndromic paediatric patients - A systematic review and meta-analysis.

Does First-Line Treatment Impact Outcomes in Trisomy 21-Associated Infantile Epileptic Spasms Syndrome? A Multicenter North American Analysis.

The Experience of Depression, Self-Efficacy, and Family Functioning Among Mothers of Children with Autism Spectrum Disorder: A Mixed Methods Study [Formula: see text].

Impact of National Screening Programs on Down syndrome prevalence and outcomes.

Second trimester quad test for fetal down syndrome screening as a predictor of spontaneous preterm birth in a developing country: a population-based study.

Case report: acute phosphine inhalation poisoning in a patient with down's syndrome.

Evolving Alzheimer's Disease Clinical Practice: Updated Diagnostic Criteria, Fluid Biomarkers, and Special Considerations for Anti-Amyloid Therapies.

Delirium and adverse clinical outcomes: a matched cohort study in the UK Biobank.

Probable cerebral amyloid angiopathy - related inflammation in a 32-year-old woman with down syndrome.

Trisomy 21 alters ciliary localization of Sonic Hedgehog signaling proteins.

Leucettinib-21 decreases dosage effects of DYRK1A in human trisomy 21 iPSC-derived neural cells.

Uptake of HPV vaccination and associated factors in France: a nationwide study from 2007 to 2023.

Levetiracetam prevents Aβ production through SV2a-dependent modulation of APP processing in Alzheimer's disease models.

Four women whose pioneering contributions to science have been largely overlooked.

Impaired BDNF-TrkB trafficking and signalling in Down syndrome basal forebrain neurons.

Transient Abnormal Myelopoiesis with Myeloid Cell Thrombus in a Case of Down Syndrome: A Rare Placental Finding.

Sod1 trisomy causes ENS developmental defects and susceptibility to Hirschsprung disease via neuronal Ret suppression and glial remodeling.

Oral hygiene and caries experience in children with down syndrome and autism spectrum disorder: a systematic review and meta-analysis.

Deep Learning-Based Eye Rubbing Detection Using Wrist-Based Wearable Devices to Enable Rigorous Study of Risk Factors for Ectasia Progression.

Swallowing characteristics in Down syndrome at an advanced age: a preclinical study in the Ts65Dn mouse model.

Gene dosage imbalance disrupts systemic metabolism in the Dp16 Down syndrome mouse model.

SOD1 at the Crossroads: Co-Overexpression of Canonical Antioxidant Response and Noncanonical Hydrogen Sulfide Generation Pathways in Down Syndrome, With Immune Cell Implications.

Transcranial Photobiomodulation for Neuromodulation of Brain Disorders: A Perspective.

Child Deictic Gesture Use and Maternal Labeling in Toddlers With Down Syndrome.

Parental perceptions and attitudes towards the inclusion of children with neurodevelopmental, physical and sensory disabilities.

Temporal dynamics of white matter hyperintensities related to Alzheimer's disease in adults with Down syndrome.

Life expectancy of people with intellectual disability: a retrospective cohort study from New South Wales, Australia.

Camp-based entertainment rehabilitation for young people with down syndrome in Saudi Arabia.

Does a TEOAE refer / AABR pass profile at the neonatal hearing screening indicate risk?

Caregiver-reported social impacts in down syndrome regression disorder.

Brain aging in neurodevelopmental disorders: a narrative review of oxidative, inflammatory, and mitochondrial mechanisms.

[Obstructive sleep apnoea in children with Down s syndrome: challenges and treatment strategies].

Validity and reliability of a scale of activities of daily living at home in children, youth and adults with Down syndrome in Chile.

Single cell analysis of developing Merkel cells reveals the emergence of non-coding RNA biotypes as a hallmark of terminal differentiation.

Outcomes of an Exercise Intervention in Adults With Down Syndrome and Congenital Heart Disease: A Secondary Analysis.

Generation of an induced pluripotent stem cell line (AHMUCNi004-A) from a 14-year-old male with Down syndrome.

Adjunctive cannabidiol in intractable pediatric epilepsy: A retrospective study on tolerability, efficacy, and safety across genetic and nongenetic etiologies.

Down syndrome birth rate post Dobbs decision: has it changed?

Attitudes Towards Medical Research Participation Among Those With Down Syndrome and Their Caregivers.

Muscle Thickness in Lower Extremity and Locomotor Functions in Children With Down Syndrome and Typical Developing Peers.

The Wnt/β-catenin pathway maintains homeostasis of amniocytes in Down syndrome.

Intracerebral age-independent reduction of endothelium-dependent hyperpolarization and nitric oxide signalling in the Dp16 mouse model of Down syndrome.

Associations between receptive and expressive vocabulary and early literacy in young students with intellectual disabilities using AAC.

DYRK1A Expression and Thyroid Dysfunction in Subjects With Down Syndrome.

Serum and cerebral folate are normal in Down Syndrome Regression Disorder.

miRNAs mediated Hsa21 gene suppression as potential therapeutic agent for Down syndrome: molecular dynamics and MM/PBSA-based study.

The characteristics and surgical outcomes of atlantoaxial instability in pediatric patients with Down syndrome: a case-match study.

Views of Facial Attractiveness of Faces of Individuals With and Without an Intellectual Disability.

Exploring behavioral dynamics: an in-depth analysis of adult students with disabilities.

Prevalence, Spectrum, and Management of Thyroid Dysfunction in Children with Down Syndrome: A Retrospective Study from Southern Saudi Arabia.

A New Hypothesis on the Etiology of Down Syndrome: The Role of Anti-Zona Pellucida Antibodies as an Age-Independent Factor.

Prevalence of Functional Constipation in Children with Down Syndrome: A Study Conducted at a General Pediatrics Service.

Moving Beyond Somatic Alterations: Uncovering the Germline Basis of Myeloid Malignancies.

Characterizing Autism Traits in Toddlers with Down Syndrome: Preliminary Associations with Language, Executive Functioning, and Other Developmental Domains.

Global and Local Processing of Letters and Faces in Children and Adolescents with Typical and Atypical Development.

The Effects of Cognitive-Motor Dual-Task Exercise and Exergaming on Balance and Functional Mobility in Children with Down Syndrome: A Comparative Randomized Trial.

Shared Disease Mechanisms in Neurodevelopmental Disorders: A Cellular and Molecular Biology Perspective.

Some Biomechanical and Anthropmetric Differences Between Elite Swimmers with Down Syndrome and Intellectual Disabilities.

New Digital Workflow for the Use of a Modified Stimulating Palatal Plate in Infants with Down Syndrome.

Technical nuances of a posterior transdural approach for resection of a compressive retro-odontoid cyst with 2D operative video and graphical illustration: illustrative case.

GATA1 N-terminus coordinates metabolic reprogramming in erythropoiesis.

Development of a novel MSRE-dPCR assay for non-invasive prenatal testing of trisomy 21.

The Dp16 Down syndrome mouse model does not exhibit oral interferon-gammopathy or susceptibility to oral candidiasis.

Evaluation of a Co-Research Program: optimising engagement in research.

Examining associations between foundational and complex mathematics skills in people with Down syndrome and typically developing children.

Generation and Exosomal Noncoding RNA Profiling of Down Syndrome-Specific Induced Pluripotent Stem Cells.

Vowel space change as a predictor of speech intelligibility gain in Down syndrome.

Synaptic and intrinsic membrane defects disrupt early neural network dynamics in Down syndrome.

The impact of congenital heart disease on the timing of Alzheimer's disease in Down syndrome.

Impact of a Pediatric Down Syndrome Clinic on the Identification of Celiac Disease in the Patient Population.

Orthodontic Appliance-Related Mucosal Ulcerations in Newborns and Infants With Craniofacial Disorders.

Moyamoya syndrome and persistent trigeminal artery: description of a case with Trisomy 21.

Single-beat method echocardiographic comparison of ventricular-arterial coupling in adults with and without Down syndrome.

Influence of posture during mastication on body composition and nutritional intake in individuals with Down syndrome.

Unravelling myelofibrosis in infants: A hidden pediatric challenge!

Dyggve-Melchior-Clausen syndrome in three siblings: a unique case series with dual diagnosis of Down syndrome and Hirschsprung disease.

Brain volume trajectories in Down syndrome and autosomal dominant Alzheimer's disease.

Incidence, patterns of clinical presentation, and haematological characteristics of paediatric acute myeloid leukaemia in Uganda: a retrospective analysis.

Single-cell atlas of the developing Down syndrome brain cortex.

Clinical Factors Associated with Postnatal Urinary Titin N-Fragment in Neonates.

Autism Observation Scale for Infants: Systematic Review and Meta-Analysis in Samples at Increased Likelihood of Autism Spectrum Disorders.

Caregiver-Reported Attainment of Developmental Skills in Down Syndrome.

Altered hepatic metabolism in Down syndrome.

Understanding of trisomy 21 prenatal screening among pregnant women in France: A cross-sectional study in light of 2019 guidelines.

ADHEAR in infants with Down syndrome and minimal hearing loss.

Is trisomy 21 a risk factor for postoperative complications after pediatric surgery for neonatal gastrointestinal disease? A retrospective study using a National Clinical Database in Japan.

[Dysfunction and premature aging of hematopoietic stem cells in Down syndrome].

What Motivates Parents of Young Children With Down Syndrome to Participate in Research: A Focus Group Analysis.

Identification of RALY as a novel regulator of DSCR1 transcription.

Concordance of Biological and Clinical Staging of Alzheimer Disease Pathology in Down Syndrome.

Relationship of cholinergic basal forebrain atrophy with the time course of Alzheimer's disease pathology and cognitive decline in adults with Down syndrome: a longitudinal cohort study.

Chronic suppression of monoacylglycerol lipase restores adult neurogenesis in the septal but not the temporal DG in Ts65Dn mouse model of Down syndrome.

A Novel Acetylcholine Nanosensor for Single Vesicle Storage and Sub-Quantal Exocytosis in Living Neurons and Organoids.

Adapted Judo as a Multidimensional Intervention: Effects on Physical Fitness and Psychosocial Well-Being in Adolescents with Down Syndrome.

A Critical Assessment of Antenatal Monitoring for Fetal Well-Being in Down Syndrome Pregnancies.

Shape and Morphology of the Sella Turcica in Patients with Trisomy 21-A Systematic Review.

THE EFFICACY OF SENSORY-ADAPTED DENTAL INTERVENTIONS FOR CHILDREN WITH DEVELOPMENTAL DISABILITIES AND SENSORY SENSITIVITIES.

Artificial intelligence application in the prediction of spontaneous preterm birth by cervical length in the first trimester of pregnancy: Comparison of three measurement methods.

A Review of Clinical Trials in Down Syndrome.

Epidemiology of congenital heart defects in live births: findings from a study in Southern Brazil.

Novel insights into Alzheimer's disease through the study of individuals with Down syndrome.

Explaining the Comprehension-Production Vocabulary Gap Through Neural Networks and Cross-Syndrome Evidence: Insights From Williams Syndrome.

Mothers' and Fathers' Recode Use With Young Children With Down Syndrome.

Review of early development in children with Down syndrome: family and clinician partnership.

A minimally invasive dried blood spot biomarker test for the detection of Alzheimer's disease pathology.

Elevated mortality and upregulated SARS-CoV-2-associated pathways in innate and adaptive immune cells from individuals with Down syndrome.

Understanding Keratoconus in Down Syndrome: From Etiology to Management - A Narrative Review.

Lingual Tonsillectomy for Resistant Obstructive Sleep Apnea in Children with Down Syndrome: A Systematic Review and Meta-Analysis.

Risk factors associated with hearing loss in neonates: A retrospective cross-sectional study from Qatar.

Association between trisomy 21 and 'puff of smoke' with an unusual presentation of transient ischaemic attack.