Prognostic Significance of DNA Repair Gene mRNA Expression in Early-Stage Breast Cancer: Insights into Clinical Relevance.

Deficiency of Werner RecQ-type DNA helicase causes premature malnutrition in zebrafish.

Discovery and Preclinical Evaluations of Potent, Selective, and Allosteric Covalent WRN Inhibitors with Improved PK Properties.

Novel Werner Syndrome RecQ DNA Helicase (WRN) Inhibitors for Cancer Treatment.

Microsatellite instable cancer cells acquire on-target resistance mutations to WRN helicase inhibitors.

Unraveling syndrome-driven osteosarcoma: genetic insights and therapeutic frontiers.

Structural insights into WRN helicase reveal conformational states and opportunities for MSI-H cancer drug discovery.

Novel Homozygous Variants in CIDEC and WRN in a Young Female with Lipodystrophy and Thyroid Cancer.

The Werner syndrome RECQ helicase as a therapeutic target: new insights.

WRN structural flexibility showcased through fragment-based lead discovery of inhibitors.

Tumorigenic p53N236S balances aging and tumorigenesis via regulating DREAM/MMB and downstream telomere DNA replication pathways.

Efficacy and safety of SGLT2 inhibitor on insulin resistance and hyperglycemia in Werner syndrome-A case report.

Targeting DNA Damage Repair Pathways Beyond PARP Inhibition.

The Relationship Between Insulin Resistance and Cancer in Humans.

The bacterial MRE11-RAD50 and DNA2-WRN homologs process replication forks at distinct and separate loci on the chromosome.

DNA repair helicases: from mechanistic understanding to therapeutic implications.

AI-assisted delivery of novel covalent WRN inhibitors from a non-covalent fragment screen.

Editor's Note: Werner Syndrome Helicase Has a Critical Role in DNA Damage Responses in the Absence of a Functional Fanconi Anemia Pathway.

Molecular Mechanisms of Proliferative Senescence and Genomic Instability in Werner Syndrome and the WRN Gene Network.

Identification of VVD-214/RO7589831, a Clinical-Stage, Covalent Allosteric Inhibitor of WRN Helicase for the Treatment of MSI-High Cancers.

Targeted degradation of Werner syndrome helicase (WRN) via ligand-directed covalent hydrophobic tagging.

WRN and WRNIP1 ATPases impose high fidelity on translesion synthesis by Y-family DNA polymerases.

High-throughput evaluation of novel WRN inhibitors.

DNA double-strand break end resection factors and WRN facilitate mitotic DNA synthesis in human cells.

Targeting the Werner syndrome protein in microsatellite instability cancers: mechanisms and therapeutic potential.

A case of rapid-progressing liver cirrhosis complicated by Werner syndrome.

An overview of RecQ helicases and related diseases.

Targeting WRN helicase: Discovery and development of its selective inhibitors.

Werner syndrome due to homozygous WRN mutation through chromosome 8 region of homozygosity in a consanguineous family.

Quinazoline Derivative kzl052 Suppresses Prostate Cancer by Targeting WRN Helicase to Stabilize DNA Replication Forks.

Thioguanine-coordinated assembly for synthetic lethality of colorectal cancer with defective mismatch repair.

Post-Translational Modifications of the Werner Syndrome Protein WRN.

Whole Exome Sequencing Identifies a Novel Frameshift Mutation of the WRN Gene in a Werner Syndrome Family and Functional Analysis.

Synthetic Lethality as Emerging Treatment for Cancer: An Example by Using the Werner Syndrome Helicase (WRN) Inhibitors.

Targeting Werner Syndrome Helicase with Small Molecules in Mismatch Repair-Deficient Cancers.

WRN as a Novel Target of Synthetic Lethality: Current Advances and Future Perspectives.

Design and synthesis of 2-amino-4-(trifluoromethyl)pyrimidine derivatives as potential Werner-dependent antiproliferative agents.

Targeting Werner Helicase: A novel combination strategy for MSI colorectal cancer.

Validation, Key Pharmacophores, and X-ray Cocrystal Structures of Novel Biochemically and Cellularly Active WRN Inhibitors Derived from a DNA-Encoded Library Screen.

Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double-Blind Randomized Crossover Placebo-Controlled Trial.

Investigating telomere length in progeroid syndromes: implications for aging disorders.

CEBPA-associated familial acute myeloid leukemia mimicking Werner syndrome: a case report.

Werner syndrome exonuclease promotes gut regeneration and causes age-associated gut hyperplasia in Drosophila.

A Rare Cause of Acute Pancreatitis: Two Siblings With Werner Syndrome.

Werner helicase as a therapeutic target in mismatch repair deficient colorectal cancer.

Decreased mitochondrial NAD+ in WRN deficient cells links to dysfunctional proliferation.

Crystal-storing histiocytosis of multiple myeloma with a novel multi-exon deletion of WRN: A case report and mini review of literature.

Discovery of novel quinazoline derivatives containing trifluoromethyl against cell proliferation by targeting werner helicase.

PLK1 phosphorylates WRN at replication forks.

Extrachromosomal circular DNA: a double-edged sword in cancer progression and age-related diseases.

A Rare Presentation of Five Primary Cancers in a Patient With Werner Syndrome: A Case Report and Literature Review.

Discovery of novel WRN inhibitors for treating MSI-H colorectal cancers.

Genetic and Epigenetic Insights into Werner Syndrome.

Long-term follow-up of a case of bilateral elbow ulcers in a patient with Werner syndrome treated with pedicled radial forearm flaps.

For early diagnosis of young patients with Werner syndrome: Indication for genetic testing.

Establishment and application of a zebrafish model of Werner syndrome identifies sapanisertib as a potential antiaging drug.

Phosphorylation-dependent WRN-RPA interaction promotes recovery of stalled forks at secondary DNA structure.

Amelioration of premature aging in Werner syndrome stem cells by targeting SHIP/AKT pathway.

A Review of Telomere Attrition in Cancer and Aging: Current Molecular Insights and Future Therapeutic Approaches.

rDNA Copy Number Variation and Methylation During Normal and Premature Aging.

Synergistic protection of nascent DNA at stalled forks by MSANTD4 and BRCA1/2-RAD51.

Efficacy of eribulin monotherapy for bone marrow carcinomatosis of breast cancer in a patient with Werner syndrome.

Specific Monitoring the DNA Helicase Function via Anchor-Embedded DNA Probe.

Application and research progress of synthetic lethality in the development of anticancer therapeutic drugs.

Less frequent skin ulcers among patients with Werner syndrome treated with pioglitazone: findings from the Japanese Werner Syndrome Registry.

Quinazoline derivatives inhibit cell growth of prostate cancer as a WRN helicase dependent manner by regulating DNA damage repair and microsatellite instability.

Design, synthesis, and structure-activity relationship studies of triazolo-pyrimidine derivatives as WRN inhibitors for the treatment of MSI tumors.

Werner syndrome RECQ helicase participates in and directs maintenance of the protein complexes of constitutive heterochromatin in proliferating human cells.

p21 Regulates Wnt-Notch balance via DREAM/MMB/Rb-E2F1 and maintains intestinal stem cell homeostasis.

Switch-like phosphorylation of WRN integrates end-resection with RAD51 metabolism at collapsed replication forks.

Peri-operative considerations for a pregnant patient with Werner syndrome and pre-eclampsia.

USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication.

Interdependence between Nuclear Pore Gatekeepers and Genome Caretakers: Cues from Genome Instability Syndromes.

Promotion of DNA end resection by BRCA1-BARD1 in homologous recombination.

Mechanism of BRCA1-BARD1 function in DNA end resection and DNA protection.

PROTAC-mediated conditional degradation of the WRN helicase as a potential strategy for selective killing of cancer cells with microsatellite instability.

WRN Nuclease-Mediated EcDNA Clearance Enhances Antitumor Therapy in Conjunction with Trehalose Dimycolate/Mesoporous Silica Nanoparticles.

Recommendations for cancer screening and surveillance in patients with Werner syndrome.

SNORD88B-mediated WRN nucleolar trafficking drives self-renewal in liver cancer initiating cells and hepatocarcinogenesis.

WRN Helicase: Is There More to MSI-H than Immunotherapy?

WRN inhibition leads to its chromatin-associated degradation via the PIAS4-RNF4-p97/VCP axis.

James German and the Quest to Understand Human RECQ Helicase Deficiencies.

High-Throughput Covalent Modifier Screening with Acoustic Ejection Mass Spectrometry.

Genomic and Transcriptomic Analysis of a Patient with Early-Onset Colorectal Cancer and Therapy-Induced Focal Nodular Hyperplasia: A Case Report.

'Werner Syndrome foot'-A case series of four Irish Traveller siblings with Werner Syndrome, diabetes mellitus and complex foot disease.

KBM-mediated interactions with KU80 promote cellular resistance to DNA replication stress in CHO cells.

RecQ helicase expression in patients with telomeropathies.

Retrotransposons in Werner syndrome-derived macrophages trigger type I interferon-dependent inflammation in an atherosclerosis model.

Integrated liver and serum proteomics uncover sexual dimorphism and alteration of several immune response proteins in an aging Werner syndrome mouse model.

Development of a Prognostic Risk Model Based on Oxidative Stress-related Genes for Platinum-resistant Ovarian Cancer Patients.

Design and synthesis of N-aryl-2-trifluoromethyl-quinazoline-4-amine derivatives as potential Werner-dependent antiproliferative agents.

WRN inhibitors squeeze cancer cell vulnerability.

Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers.

Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.

DNA repair deficiencies and neurodegeneration.

Werner Syndrome and Diabetes: Opportunities for Precision Medicine.

Novel WRN Helicase Inhibitors Selectively Target Microsatellite-Unstable Cancer Cells.

Targeting ATP-binding site of WRN Helicase: Identification of novel inhibitors through pocket analysis and Molecular Dynamics-Enhanced virtual screening.

Discovering potential WRN inhibitors from natural product database through computational methods.

WRN exonuclease imparts high fidelity on translesion synthesis by Y family DNA polymerases.

Dietary restriction fails to extend lifespan of Drosophila model of Werner syndrome.

Premature aging in genetic diseases: what conclusions can be drawn for physiological aging.

Breast cancer in a Hispanic patient with Werner syndrome.

Challenges for the Discovery of Non-Covalent WRN Helicase Inhibitors.

Discovery of thiophen-2-ylmethylene bis-dimedone derivatives as novel WRN inhibitors for treating cancers with microsatellite instability.

A Novel Variant in the WRN Gene Detected in a Case of Early-Onset Severe Insulin Resistance Displaying Some but Not All Hallmarks of Progeroid Werner Syndrome.

WRN loss accelerates abnormal adipocyte metabolism in Werner syndrome.

CRL2APPBP2-mediated TSPYL2 degradation counteracts human mesenchymal stem cell senescence.

The function of Bazhen decoction in rescuing progeroid cell senescence via facilitating G-quadruplex resolving and telomere elongation.

Werner Syndrome Caused by Homozygous Frameshift Variant c.1578del in WRN.

Sclerosing epithelioid fibrosarcoma associated with WRN gene variant presenting as chronic dyspnea and pathologic cervical fracture: a case report and review of the literature.

The dual role of the DREAM/G2M pathway in non-tumorigenic immortalization of senescent cells.

Sex differences in symptom presentation and their impact on diagnostic accuracy in Werner syndrome.

Case of Werner syndrome complicated with Sjögren's syndrome and Hashimoto's thyroiditis presenting sclerosing panniculitis-like symptoms.

Werner helicase mediates the senescence and cell cycle of leukemia cells by regulating DNA repair pathways.

WRN Is a Promising Synthetic Lethal Target for Cancers with Microsatellite Instability (MSI).

Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR.

Flame-like Calcifications in Werner Syndrome.

The identification of a novel mutation (p.I223fs) in WRN associated with Werner syndrome.

Modified iPOND revealed the role of mutant p53 in promoting helicase function and telomere maintenance.

Early-onset diabetes mellitus as a presenting feature of Werner's syndrome in an Indian family.

Senescence-associated inflammation and inhibition of adipogenesis in subcutaneous fat in Werner syndrome.

Senescence, regulators of alternative splicing and effects of trametinib treatment in progeroid syndromes.

PHOSPHORYLATION-DEPENDENT ASSOCIATION OF WRN WITH RPA IS REQUIRED FOR RECOVERY OF REPLICATION FORKS STALLED AT SECONDARY DNA STRUCTURES.

ssDNA reeling is an intermediate step in the reiterative DNA unwinding activity of the WRN-1 helicase.

Brain and/or Spinal Cord Tumors Accompanied with Other Diseases or Syndromes.

Werner syndrome associated with poorly differentiated thyroid carcinoma and systemic sclerosis-like skin manifestations: A case report.

Identification of 2-Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay.

Cancer aneuploidies are shaped primarily by effects on tumour fitness.

Werner syndrome as a crossroads between lipodystrophy, escleroderma-like changes and torpid ulcers in lower limbs.

A rapid and highly sensitive immunosorbent assay to monitor helicases unwinding diverse nucleic acid structures.

Renal dysfunction, malignant neoplasms, atherosclerotic cardiovascular diseases, and sarcopenia as key outcomes observed in a three-year follow-up study using the Werner Syndrome Registry.

RecQ dysfunction contributes to social and depressive-like behavior and affects aldolase activity in mice.

Identification of Novel Senescent Markers in Small Extracellular Vesicles.

Case of Werner syndrome with significant improvement of refractory skin ulcer despite fibroblast cellular senescence.

Quality of life in Werner syndrome and associated subjective foot/ankle symptoms: A cross-sectional survey.

Combination of untargeted and targeted proteomics for secretome analysis of L-WRN cells.

A non-catalytic N-terminus domain of WRN prevents mitotic telomere deprotection.

WRN suppresses p53/PUMA-induced apoptosis in colorectal cancer with microsatellite instability/mismatch repair deficiency.

Targeting G-quadruplex for rescuing impaired chondrogenesis in WRN-deficient stem cells.

Werner syndrome protein works as a dimer for unwinding and replication fork regression.

RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells.

WRN helicase and mismatch repair complexes independently and synergistically disrupt cruciform DNA structures.

Werner helicase is required for proliferation and DNA damage repair in multiple myeloma.

Synthetical lethality of Werner helicase and mismatch repair deficiency is mediated by p53 and PUMA in colon cancer.

Optical coherence tomography findings in three patients with Werner syndrome.

Adult progeria: a new mutation in the WRN gene.

Biochemical and functional characterization of an exonuclease from Chaetomium thermophilum.

Research on Werner Syndrome: Trends from Past to Present and Future Prospects.

Werner syndrome associated with acroosteolysis.

A homozygous missense variant in the WRN gene segregating in a family with progressive pulmonary failure with recurrent spontaneous pneumothorax and interstitial lung disease.

Literature-based translation from synthetic lethality screening into therapeutics targets: CD82 is a novel target for KRAS mutation in colon cancer.

A rare syndrome mimicking scleroderma: Werner syndrome.

Peripheral neuropathies associated with DNA repair disorders.

WRN promotes bone development and growth by unwinding SHOX-G-quadruplexes via its helicase activity in Werner Syndrome.

DNA fiber analyses to study functional importance of helicases and associated factors during replication stress.

Case Report: A novel WRN mutation in Werner syndrome patient with diabetic foot disease and myelodysplastic syndrome.

Partial lipodystrophy, severe dyslipidaemia and insulin resistant diabetes as early signs of Werner syndrome.

WRN rescues replication forks compromised by a BRCA2 deficiency: Predictions for how inhibition of a helicase that suppresses premature aging tilts the balance to fork demise and chromosomal instability in cancer.

Lifetime extension and the recent cause of death in Werner syndrome: a retrospective study from 2011 to 2020.

XPG in the Nucleotide Excision Repair and Beyond: a study on the different functional aspects of XPG and its associated diseases.

Non-enzymatic function of WRN RECQL helicase regulates removal of topoisomerase-I-DNA covalent complexes and triggers NF-κB signaling in cancer.

Targeted long-read sequencing identifies missing pathogenic variants in unsolved Werner syndrome cases.

A Werner Syndrome with Psychiatric Symptoms: Case Report.

Radiotherapy and radiosensitivity syndromes in DNA repair gene mutations.

SHP2's gain-of-function in Werner syndrome causes childhood disease onset likely resulting from negative genetic interaction.

Combination immunotherapy of nivolumab plus ipilimumab in a lung cancer patient with Werner syndrome; a case report.

Treatment of osteoporosis associated with Werner syndrome: A three-case report.

A Patient with Werner's Syndrome Who Underwent Aortic Valve Replacement through Minimally Invasive Cardiac Surgery.

A high prevalence of myeloid malignancies in progeria with Werner syndrome is associated with p53 insufficiency.

R-Loop-Associated Genomic Instability and Implication of WRN and WRNIP1.

Paradoxical role of the major DNA repair protein, OGG1, in action-at-a-distance mutation induction by 8-oxo-7,8-dihydroguanine.

DNA methylation signatures in Blood DNA of Hutchinson-Gilford Progeria syndrome.

Werner syndrome in a Lebanese family.

Cancer-Predisposition Genetic Analysis in Children with Brain Tumors Treated at a Single Institution in Japan.

Calcification in Werner syndrome associated with lymphatic vessels aging.

Characterization of Stress Responses in a Drosophila Model of Werner Syndrome.

MUT-7 Provides Molecular Insight into the Werner Syndrome Exonuclease.

Examination of the body composition of patients with Werner syndrome using bioelectrical impedance analysis.

WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells.

CDK2 phosphorylation of Werner protein (WRN) contributes to WRN's DNA double-strand break repair pathway choice.

Werner syndrome presenting as early-onset diabetes: A case report.

Generalized lipoatrophy syndromes.

Atherosclerosis and Cardiovascular Diseases in Progeroid Syndromes.

[Basic science of Werner syndrome].

[Clinical advances in Werner syndrome].

Human RecQL4 as a Novel Molecular Target for Cancer Therapy.

Crosstalk among DNA Damage, Mitochondrial Dysfunction, Impaired Mitophagy, Stem Cell Attrition, and Senescence in the Accelerated Ageing Disorder Werner Syndrome.

Reactive Species in Progeroid Syndromes and Aging-Related Processes.

Type I Interferon Induction in Cutaneous DNA Damage Syndromes.

The WRN helicase: resolving a new target in microsatellite unstable cancers.

Action-at-a-distance mutations at 5'-GpA-3' sites induced by oxidised guanine in WRN-knockdown cells.

DNA Damage-Induced Neurodegeneration in Accelerated Ageing and Alzheimer's Disease.

Cerebral pathological findings in long-lived patient with Werner syndrome and dementia.

Mutations Involved in Premature-Ageing Syndromes.

Generation of disease-specific and CRISPR/Cas9-mediated gene-corrected iPS cells from a patient with adult progeria Werner syndrome.

Successful allogeneic stem cell transplantation of a patient with Werner syndrome and acute myeloid leukemia.

General anesthesia for old Werner syndrome patient: a case report.