Survival in infants with trisomy 18, palliative care and ethical reflections: a single center considerations.

Clinical course and perinatal management of fetuses and newborns affected by trisomy 13 and 18: a retrospective single-centre cohort study.

Calculation of specific risk of trisomy 13: probably still a utopia.

An ethical issue in the prenatal and postnatal management of trisomy 18: a survey of obstetricians.

Epigenome-wide profiling of trisomy 18 specific DNA methylation signatures in first-trimester chorionic villi.

A case of primary cutaneous diffuse large B-cell lymphoma, leg type with MYC rearrangement and high BCL2 protein expression due to trisomy 18.

Multiple, bilateral choroidal macrovessels with visible pulsations in an infant with trisomy 18.

Trisomy 18 and Ambiguous Genitalia: A Case Report.

[Between ethics and practice : thoughts about the clinical management of an infant with trisomy 18 (Edwards syndrome)].

Cell-free DNA screening for trisomies 21, 18, and 13: Clinical application and accuracy evaluation.

Current prenatal counseling of congenital heart disease in trisomy 18, pediatric cardiologists' perspective: a Fetal Heart Society Research Collaborative Study.

Edwards syndrome: Neurocognitive and linguistic profile, diagnosis, overlaps and treatment.

Long-Term Survival Among Children With Trisomy 13 and Trisomy 18 by Cytogenetic Status.

Successful long-term survival of patients with trisomy 18 and hepatoblastoma after cardiac surgery.

Surviving trisomy 18: A case report of a 5-year-old girl.

Current Nationwide Landscape of Cardiac Surgery for Children With Trisomy 18 in Japan.

Predictive value of the maternal alpha-fetoprotein variant, L2, during the first trimester of pregnancy screening for fetal trisomy 21, trisomy 18, and neural tube defects.

Guidance for Caring for Infants and Children With Trisomy 13 and Trisomy 18: Clinical Report.

Pregnancy outcomes in patients with increased nuchal translucency using non-invasive prenatal testing and first trimester ultrasound.

Counseling prior to cfDNA screening: are we giving the right numbers?

[Development and application of a digital PCR-based assay for rapid diagnosis of common fetal chromosomal aneuploidies].

Comparative performance and health economic analysis of prenatal screening for down syndrome in Fujian province, China.

[Genetic etiology of trisomy].

Outcomes of heart surgery in neonates with trisomy 13 and 18: a systematic review with metanalysis.

Chorionic Villus Sampling for Rapid Confirmation of High-Risk NIPT Results for Trisomy 21, 18, and 13.

Ethical challenges and justice concerns for infants and children with life-limiting conditions and significant disability, including trisomy 13 and 18.

Maternal Age-Related Gender Bias in Trisomy 21 and Trisomy 18.

Establishment of human induced pluripotent stem cell line BAFYi001-A from a patient with Edwards syndrome.

Concomitant omphalocele, craniorachischisis and ectopic cordis associated with trisomy 18 diagnosed in first trimester.

Liveborn children with trisomy 18: A scoping review.

Gastrostomy Tube Placement in Patients With Trisomy 13 and 18: Surgical Decision Making and Outcomes.

Parental perspectives of trisomy 18: common threads of a life-limiting diagnosis.

Early assessment of clinical complexity and home care in patients affected by trisomy 13 and 18.

Advocating a specific risk calculation of trisomy 18 in case of low maternal serum markers during screening for fetal Down syndrome.

Trisomy 18 and the possibility of choice: The importance of Perinatal Hospice's support.

Accuracy of cell-free fetal DNA in detecting chromosomal anomalies in women experiencing miscarriage: systematic review and meta-analysis.

Family-Centered Antenatal Care With a Life-Limiting Fetal Condition: A Developmental Theory-Guided Approach.

Amniotic fluid glucose concentration as a predictor of fetal trisomy.

Parent Narratives Provide Perspectives on the Experience of Care in Trisomy 18.

Pregnancies with 'double-positive' multiple marker screening results: a population-based study in Ontario, Canada.

Surgery for hepatoblastoma in children with trisomy 18: a monocentric study.

Infertility following trisomic pregnancies: A nationwide cohort study.

Rapid detection of paternal origin of trisomy 18 by quantitative fluorescent polymerase chain reaction analysis in a fetus associated with increased nuchal translucency thickness and in a pregnancy without an advanced maternal age.

Potential efficacy of digital polymerase chain reaction for non-invasive prenatal screening of autosomal aneuploidies: a systematic review and meta-analysis.

Management and Outcomes of Hepatoblastoma in Patients With Trisomy 18: A Systematic Review and Pooled Analysis of 70 Patients.

Prevalence and clinical characterization of oral clefts in patients with chromosome trisomy 18.

Impact of definitive surgery for esophageal atresia on long-term outcomes in patients with trisomy 18.

Imaging Findings and MRI Patterns in a Cohort of 18q Chromosomal Abnormalities.

Pregnant women in UK offered extra opportunity to screen for Edwards' syndrome.

Therapeutic Management and Outcomes of Hepatoblastoma in a Pediatric Patient with Mosaic Edwards Syndrome.

Fetal trisomy 18 associated with congenital diaphragmatic hernia, choroid plexus cysts, clenched hands and a maternal origin of the extra chromosome 18.

Rapid detection of maternal origin of trisomy 18 by quantitative fluorescent polymerase chain reaction in a fetus associated with increased nuchal translucency thickness and omphalocele on first-trimester prenatal ultrasound.

False positive non-invasive prenatal testing (NIPT) for trisomy 12 in a pregnancy associated with a favorable fetal outcome and normal hemogram in the pregnant woman.

Performance of cell-free DNA testing for common fetal trisomies in triplet pregnancies.

Metastatic adrenal gland neuroblastoma in an infant with trisomy 18: A case report.

Cases of trisomy 21 and trisomy 18 among historic and prehistoric individuals discovered from ancient DNA.

Contemporary Trends in Cardiac Surgical Care for Trisomy 13 and 18 Patients Admitted to Hospitals in the United States.

A Long-Term Survivor of Trisomy 18.

The American Association for Thoracic Surgery (AATS) 2023 Expert Consensus Document: Recommendation for the care of children with trisomy 13 or trisomy 18 and a congenital heart defect.

3D ultrasound evaluation of fetal ears in prenatal syndrome diagnosis - a comparative study.

The outcome of trisomy 18 pregnancies following the legalisation of termination of pregnancy.

Double aneuploidy in a 2-month-old male with Edward syndrome and Klinefelter syndrome: a case report.

[Clinical application of non-invasive prenatal testing for twin pregnancies].

[Genetic analysis of the false positive trisomy 7 and false negative trisomy 18 by NIPT-PLUS].

[Prenatal diagnosis and outcome of pregnancy for women with high risks by screening of fetal free DNA from peripheral blood samples].

Troubleshooting Tips for Diagnosing Complex Fetal Genitourinary Malformations.

Atypicality index as an add-on to combined first-trimester screening for chromosomal aberrations.

Importance of a detailed anomaly scan after a cfDNA test indicating fetal trisomy 21, 18 or 13.

Patau and Edwards Syndromes in a University Hospital: beyond palliative care.

Recognizing the importance of adequate follow-up for hearing impairment in trisomy 18.

Treatment courses and outcomes of oesophageal atresia in patients with trisomy 18: a case series of 271 patients from a nationwide database in Japan.

Successful Treatment for Hepatoblastoma in Trisomy 18: A Case Report.

Cause, severity, and efficacy of treatment for hearing loss in children with Trisomy 18: A single institution-based retrospective study.

Significant improvement in survival outcomes of trisomy 18 with neonatal intensive care compared to non-intensive care: a single-center study.

Comprehensive phenotyping of fetuses with trisomy 18: a perinatal center experience.

False positive non-invasive prenatal testing (NIPT) for trisomy 21 in vanishing twin syndrome pregnancy: A comparison of the NIPT results performed in different gestations.

The correlation with abnormal fetal outcome and a high level of amniotic fluid alpha-fetoprotein in mid-trimester.

Artificial intelligence for prenatal chromosome analysis.

Maternal age and the risk of fetal aneuploidy: A nationwide cohort study of more than 500 000 singleton pregnancies in Denmark from 2008 to 2017.

Indications, types, and diagnostic implications of prenatal genetic testing in Sub-Saharan Africa: A descriptive study.

Economic cost of patients with trisomy 13, 18, and 21 in a tertiary hospital in Thailand.

Optimal Surgical Method and Timing for Low-birth-weight Esophageal Atresia Babies: Multi-institutional Observational Study.

The value of combined detailed first-trimester ultrasound-biochemical analysis for screening fetal aneuploidy in the era of non-invasive prenatal testing.

Airway findings in trisomy 13 and trisomy 18: A 10-year retrospective review.

Anesthetic Management of Inguinal Hernia Surgery Using a Second-Generation Supraglottic Airway in a Patient With Trisomy 18: A Case Report.

Causes of death in individuals with trisomy 18 after the first year of life.

A novel artificial intelligence model for fetal facial profile marker measurement during the first trimester.

Screen-positive rate in cell free DNA screening for trisomy 21.

Wilms Tumor in Child With Trisomy 18 and Horseshoe Kidney.

Effectiveness of cardiac palliative surgery for trisomy 18 patients with increased pulmonary blood flow.

Clinical Potential of Expanded Noninvasive Prenatal Testing for Detection of Aneuploidies and Microdeletion/Microduplication Syndromes.

Structured Framework for Multidisciplinary Parent Counseling and Medical Interventions for Fetuses and Infants with Trisomy 13 or Trisomy 18.

Analysis of the results of non-invasive prenatal testing (NIPT) in 545 pregnant women in advanced maternal age.

Effect of maternal polycystic ovary syndrome (PCOS) on screening of aneuploidy in the first and second trimesters.

The common trisomy syndromes, their cardiac implications, and ethical considerations in care.

[Retrospective analysis of cell-free fetal DNA prenatal testing of maternal peripheral blood].

Characteristics of hearing impairment in patients with trisomy 18.

[Contribution of cytogenetic in the diagnosis of Edwards's syndrome: about 9 cases].

Application of QF-PCR Technology Combined With Early Pregnancy Ultrasound in Prenatal Screening for Fetal Chromosomal Aneuploidy.

Variants in FREM1 and trisomy 18 identified in a neonatal progeria patient.

Syndromic congenital diaphragmatic hernia: Current incidence and outcome. Analysis from the congenital diaphragmatic hernia study group registry.

Prenatal diagnosis of mosaic trisomy 18 and maternal uniparental disomy 18 by amniocentesis in a pregnancy associated with cytogenetic discrepancy in various tissues and a favorable fetal outcome.

First Croatian Case of Double Aneuploidy: A Child With Klinefelter and Edwards Syndrome (48,XXY,+18) - Possible Causes and Contributing Factors.

Incidence and outcome of arrhythmias and electrical disease in patients with Trisomy 18.

Non-invasive prenatal testing (NIPT) in twin pregnancies affected by early single fetal demise: A systematic review of NIPT and vanishing twins.

Impact of COVID-19 and vaccination on first and second trimester screening results.

Survival of children with trisomy 18 associated with the presence of congenital heart disease and intervention in the Republic of Korea.

Prenatal diagnosis and molecular genetic analysis of recurrent trisomy 18 of maternal origin in two consecutive pregnancies.

Otolaryngologic Manifestations of Trisomy 13 and Trisomy 18 in Pediatric Patients.

Association between low fetal fraction in cell-free DNA screening and fetal chromosomal aberrations: A systematic review and meta-analysis.

[Prenatal diagnosis and pregnancy outcome of fetuses with rare autosomal trisomies indicated by non-invasive prenatal testing].

Prenatal screening tests and prevalence of fetal aneuploidies in a tertiary hospital in Thailand.

Prenatal echocardiography in Trisomy 18 - the key to diagnosis and further management in the second half of pregnancy.

Pregnancy outcomes and prenatal traditional karyotype analysis with fetal omphalocele.

Cell-free DNA screening for trisomy 21 in twin pregnancy: a large multicenter cohort study.

Difficult airway management in children with trisomy 18: a retrospective single-centre study of incidence, outcomes, and complications.

Ethical Implications of Cleft Lip and Palate Repair in Patients with Trisomy 13 and Trisomy 18.

Phenotypic Spectrum of Trisomy 18 Mosaicism: a New Patient and Literature Review.

Ten-year survival of children with trisomy 13 or trisomy 18: a multi-registry European cohort study.

Management and survival of foetuses with trisomy 18 in a French retrospective cohort.

Maternal prenatal screening programs that predict trisomy 21, trisomy 18, and neural tube defects in offspring.

Trisomy 18: disparities of care and outcomes in the State of Texas between 2009 and 2019.

A cross-country comparison of pregnant women's decision-making and perspectives when opting for non-invasive prenatal testing in the Netherlands and Belgium.

Fetal Tethered Spinal Cord: Diagnostic Features and Its Association with Congenital Anomalies.

[Clinical application and evaluation of health economics for non-invasive prenatal testing of fetuses in Tianjin].

Cytogenetic outcomes following a failed cell-free DNA screen: a population-based retrospective cohort study of 35,146 singleton pregnancies.

Seizures in trisomy 18: Prevalence, description, and treatment.

Fetal Cerebellar Growth Curves Based on Biomathematics in Normally Developing Japanese Fetuses and Fetuses with Trisomy 18.

Prenatal and fetal diagnosis of trisomy 18 after low-risk cell-free fetal DNA screening: A report of four cases.

Positive predictive values and outcomes for uninformative cell-free DNA tests: An Italian multicentric Cytogenetic and cytogenomic Audit of diagnOstic testing (ICARO study).

Survival rates and outcomes of pregnancies with prenatal diagnosis of trisomy 18: A 16-year experience from a public hospital in South Africa.

Surgical History and Outcomes in Trisomy 13 and 18: A Thirty-year Review.

Noninvasive Prenatal Screening for Trisomy 21 in Patients with a Vanishing Twin.

Positive predictive value of a single nucleotide polymorphism (SNP)-based NIPT for aneuploidy in twins: Experience from clinical practice.

[Clinical evaluation of true and false positive Z values among high-risk cases screened by non-invasive prenatal testing].

Clinical value of fetal facial profile markers during the first trimester.

Circulating Cell-free DNA and Screening for Trisomies.

The accuracy and feasibility of noninvasive prenatal testing in a consecutive series of 20,626 pregnancies with different clinical characteristics.

[Analysis of the factors influencing positive predictive value of noninvasive prenatal testing for chromosome aneuploidies].

Diagnostic value of maternal alpha-fetoprotein variants in second-trimester biochemical screening for trisomy 21 and 18.

Whole genome non-invasive prenatal testing in prenatal screening algorithm: clinical experience from 12,700 pregnancies.

Misdiagnosis of trisomy 13 and trisomy 18 is more common than anticipated.

The Use of Caffeine for Apnoea Associated with Trisomy 13 and Trisomy 18.

A rare case report of Edwards syndrome with immature teratoma in submandibular region and literature review.

Mosaic trisomy 18 at amniocentesis associated with a favorable fetal outcome in a pregnancy.

Cytogenetic discrepancy between uncultured amniocytes and cultured amniocytes in mosaic trisomy 18 at amniocentesis in a pregnancy with a favorable fetal outcome and maternal uniparental disomy 18.

[Early warning of low maternal unconjugated estriol level by prenatal screening for fetus with X-linked ichthyosis].

Very low birth weight infants with congenital heart disease: A multicenter cohort study in Japan.

An improved deep convolutional neural network architecture for chromosome abnormality detection using hybrid optimization model.

Noninvasive prenatal screening using cell-free DNA.

Survival Outcomes of Infants with the Trisomy 13 or Trisomy 18 Syndromes.

Systematic evidence-based review: The application of noninvasive prenatal screening using cell-free DNA in general-risk pregnancies.

Detection of maternal origin of fetal trisomy 18 in a pregnancy with incidental detection of low-level mosaicism for X aneuploidy in a 46-year-old woman.

Cell-free DNA analysis for noninvasive examination of trisomy: comparing 2 targeted methods.

Prenatal diagnosis of acrania/exencephaly/anencephaly sequence (AEAS): additional structural and genetic anomalies.

Trisomy 18-when the diagnosis is compatible with life.

Discordant cfDNA-NIPT result unraveling a trisomy 12 chronic lymphocytic leukemia in a 37 years old pregnant woman.

Cerebral white matter abnormalities associated with chromosome 18q duplication.

Perinatal Outcomes of Fetuses and Infants Diagnosed with Trisomy 13 or Trisomy 18.

Future Perspectives in Oxidative Stress in Trisomy 13 and 18 Evaluation.

[Retrospective and cost-effective analysis of the result of Changsha Municipal Public Welfare Program by Noninvasive Prenatal Testing].

A study on non-invasive prenatal screening for the detection of aneuploidy.

Implementation of non-invasive prenatal testing within a national UK antenatal screening programme: Impact on women's choices.

A machine learning technology to improve the risk of non-invasive prenatal tests.

Primary cell-free DNA screening or contingent screening for the common trisomies: a response.

Prenatal phenotypic spectrum of full trisomy 18 in an Indian cohort.

Morbidity and mortality following noncardiac surgical procedures among children with autosomal trisomy.

Cell-free DNA screening for trisomies 21, 18, and 13 in pregnancies at low and high risk for aneuploidy with genetic confirmation.

Unilateral internal carotid artery absence in trisomy 18.

The impact of prenatal screening tests on prenatal diagnosis in Taiwan from 2006 to 2019: a regional cohort study.

Cardiac Interventions for Patients With Trisomy 13 and Trisomy 18: Experience, Ethical Issues, Communication, and the Case for Individualized Family-Centered Care.

Improving survival in patients with trisomy 18.

Umbilical artery pulsatility index and half-peak systolic velocity in second- and third-trimester fetuses with trisomy 18 and 13.

Clinical Application of Noninvasive Prenatal Testing for Pregnant Women with Assisted Reproductive Pregnancy.

[Analysis to the failure rate and causes of noninvasive prenatal testing based on high-throughput sequencing].

Underestimation of Trisomy 18 and 13 Syndromes in Vital Statistics from Inadequate Death Certificates.

Neurosurgical Evaluation and Management of Patients with Chromosomal Abnormalities.

Effect of preexamination conditions in a centralized-testing model of non-invasive prenatal screening.

Caffeine for the Treatment of Central Apnea in Trisomy 18: A Case Study in the Novel Use of Methylxanthines in Palliative Transport.

Pulmonary vascular resistance and compliance in individuals with trisomy 18.

What are the ethical issues involved in noninvasive prenatal testing in Japan?

[Analysis of the results of chromosomal trisomies 21, 18 and 13 screening among 40 628 women by non-invasive prenatal testing].

[Congenital heart disease associated with the most prevalent chromosomal syndromes: a literature review].

Audit of the first > 7500 noninvasive prenatal aneuploidy tests in a Swiss genetics center.

[Is it necessary to choose NIPT-plus for pregnant women who opt for non-invasive prenatal testing? A study of 50 cases].

Assessment and Clinical Utility of a Non-Next-Generation Sequencing-Based Non-Invasive Prenatal Testing Technology.

Survival outcomes of very low birth weight infants with trisomy 18.

Trisomy 18 Trends over the Last 20 Years.

VACTERL Associated with a Rare Limb Anomaly Combined with Edward (Trisomy 18) Syndrome.

Management of Children with the Trisomy 18 and Trisomy 13 Syndromes: Is there a Shift in the Paradigm of Care?

Double outlet right ventricle in the setting of hypoplastic left ventricle, mitral atresia, interruption of aortic arch, and uncommon intra-atrial anomalies in Trisomy 18.

Application of Multiple Short Tandem Repeat Loci for Rapid Diagnosis of Down Syndrome and Edward Syndrome.

Contingent prenatal screening for frequent aneuploidies with cell-free fetal DNA analysis.

Single-cell chromatin accessibility landscape of human umbilical cord blood in trisomy 18 syndrome.

Society for Maternal-Fetal Medicine Consult Series #57: Evaluation and management of isolated soft ultrasound markers for aneuploidy in the second trimester: (Replaces Consults #10, Single umbilical artery, October 2010; #16, Isolated echogenic bowel diagnosed on second-trimester ultrasound, August 2011; #17, Evaluation and management of isolated renal pelviectasis on second-trimester ultrasound, December 2011; #25, Isolated fetal choroid plexus cysts, April 2013; #27, Isolated echogenic intracardiac focus, August 2013).

The introduction of clinical genetic testing in Ethiopia: Experiences and lessons learned.

A visual tool inclusive of fetal ultrasound and autopsy findings to reach a balanced approach to counseling on trisomy 18 in early second trimester.

Medical and surgical interventions and outcomes for infants with trisomy 18 (T18) or trisomy 13 (T13) at children's hospitals neonatal intensive care units (NICUs).