IFI16 is essential to linking DNA damage and ferroptosis in acute kidney injury.

The Effect of AZD5153 on Radiosensitivity in Pancreatic Cancer Cells Through ATM-chk1 Pathway.

Aptamer-functionalized exosomes combined with doxorubicin suppress GBM progression and enhance chemoradiosensitivity by promoting pyroptosis.

Berzosertib enhances the sensitivity of pediatric diffuse midline glioma H3K27-altered cells to radiotherapy.

Discovery of GBA-16-24 as a highly potent, selective ATR inhibitor for the treatment of FLT3-mutated acute myeloid leukemia.

Microenvironmental acidosis drives PARP- and ATM inhibitor resistance in p53 deficient pancreatic cancer.

Richard Gatti: From concert pianist to bone marrow transplants and the DNA damage response syndrome, ataxia-telangiectasia.

Genomic Features and Response to Poly(ADP-ribose) Polymerase Inhibition in Metastatic Castration-Resistant Prostate Cancer.

Discovery of dihydrospiro[cyclopropane-1,7'-pyrrolo[3,4-d]pyrimidine] derivatives as novel ATR inhibitors.

Serum alpha fetoprotein in Ataxia Telangiectasia: New lessons about an old biomarker.

Case Report: Ataxia telangiectasia with severe hemorrhagic cystitis.

Rethinking Corticosteroid Therapy in Pediatric Neurology.

Hepatitis C Virus Core Induces p53 Ser-15 Phosphorylation to Facilitate E6-Associated Protein-Mediated Proteasomal Degradation of p53.

ATR Blockade Potentiates the Effects of Genotoxic Agents In Vitro and Promotes Antitumor Immunity in a Mouse Model of Non-Small Cell Lung Cancer.

POLQ promotes tumor progression and immunosuppression via ATM‑P53 signaling in endometrial cancer.

A phase 1 study of berzosertib (M6620, VX-970) in combination with cisplatin and radiation in patients with locally advanced head and neck squamous cell carcinoma (ETCTN 9950).

cGAS/STING-mediated upregulation of NKG2D ligands in LSCs contributes to enhanced sensitivity to NK cells.

Therapy With Doxycycline and Hydroxychloroquine Enables Surgical Excision of Ulcerated Cutaneous Granulomas in a Patient With Ataxia Telangiectasia.

Next Generation DNA Damage Response Inhibitors: Harnessing Nanocarriers and Tumor Microenvironment for Precision Cancer Therapy.

Prognostic Significance of DNA Repair Gene mRNA Expression in Early-Stage Breast Cancer: Insights into Clinical Relevance.

Physalin A interferes with cell cycle in human oral squamous carcinoma cells via DNA topoisomerase II/ATM/ATR/Chk signaling for G2/M phase arrest.

Differential modulation of haematopoietic and oxidative injury by PARP-1 and ATR kinase inhibition in a murine model of acute irradiation.

ZFP161 promotes colorectal cancer progression by transcriptionally activating c-MYC.

Inhibition of Autophagy Reveals ATR Protein Kinase as a Key Mediator of Cisplatin Sensitivity in Osteosarcoma.

Design and Synthesis of Pyrrolo[3,4-d]pyrimidine-Based ATR Degraders for Effective Treatment of Colorectal Cancer in Mouse Model.

Targeting ATR in Cancer therapy: A drug discovery perspective.

Molecular Effect of Tobacco on Genetic, Epigenetic, and Metabolic Pathways During Cancer Progression.

Targeting the FNIP2-SERCA2b axis improves metabolic and mitochondrial defects in Ataxia Telangiectasia.

GPI inactivation mediates pentose phosphate pathway flux switch-on inducing temozolomide resistance in glioma stem cell.

Neonatal Hyperoxia Induces Metabolic Reprogramming in Senescent Alveolar Macrophages, Leading to Persistent Lung Injury.

Dysregulation of the DNA damage response by phosphorothioate antisense oligonucleotides.

BRAT1 gene compound heterozygous mutations causing lethal neonatal rigidity and multifocal seizure syndrome: a case report.

First 2-year experience of nationwide newborn screening for severe forms of T and B cell immunodeficiency: 2.3 million newborns analyzed using TREC and KREC in Russia.

Esophageal Cancer Cells Exhibit Heterogeneity in DNA Double-Strand Break Repair and G2/M Checkpoint Arrest Associated With Cell Viability After Ionizing Radiation.

Pharmacodynamics, Efficacy, and Safety of Intraputaminal Eladocagene Exuparvovec Administered to Pediatric Patients With Aromatic L-Amino Acid Decarboxylase Deficiency Using an MR-Compatible Cannula: 48 Weeks of Follow-Up.

Endogenous inhibitors of PP2A activate oncogenic and DNA damage response kinases in glioblastoma.

All-trans retinoic acid enhances the anti-angiogenic effects of hemoporfin-mediated photodynamic therapy via the ATM-SerRS-VEGFA axis in endothelial cells.

Large-scale mapping of environmental-genetic interactions illustrates the dynamic nature of cell-cycle and DNA repair regulation.

Novel genetic variants identification and immune profiling in ataxia telangiectasia patients.

Analysis of the regulation of model parameters on delay time in the p53 dynamical response to single-stranded breaks.

Incorporating Patient Perspectives into a Composite Score for Measuring Disease Progression in Spinocerebellar Ataxia (SCA).

Computational and Experimental Verification of Cabozantinib Targeting DDX11 to Inhibit DNA Damage Repair in Liver Cancer.

Malignancies in the context of Inborn errors of immunity: an immunologist's view.

Energetically equivalent structural transitions in the Rad17-Rad9-Hus1-Rad1-Rhino complex underlie the sequential progression from activation through maintenance to inactivation of the ATR-dependent DNA damage response.

M1C mediates LINE-1 transcription in PARP inhibitor-treated prostate cancer cells.

Rewiring melanoma cell fate: TRPM8 modulators trigger apoptosis and boost NK cell cytotoxicity.

Targeting ATR-CHK1 and ATM-CHK2 Axes in Pancreatic Cancer-A Comprehensive Review of Literature.

RAD51 succinylation regulates homologous recombination and contributes to the chemosensitivity in cancer.

Comparing and combining xevinapant with ATR and PARP inhibition for the radiosensitization of HPV-negative HNSCC cells.

Ataxia-telangiectasia in pediatric neurology clinics: A retrospective multicenter study.

Ataxia-telangiectasia mutated kinase inhibition overcomes gemcitabine resistance in intrahepatic cholangiocarcinoma via DNA ligase I-dependent repair vulnerability.

Evaluation of protein expression and oxidative stress index in Duchenne muscular dystrophy.

ATM Inhibition Enhances Knock-in Efficiency by Suppressing AAV-Induced Activation of Apoptotic Pathways.

Targeting ATR signaling in sarcoma with homologous recombination deficiency.

Targeting Galectin-9 to overcome immunosuppression and potentiate ATR inhibitor therapy.

Immunotherapy response in microsatellite-stable poorly differentiated thyroid carcinoma with mismatch repair deficiency and high tumor mutational burden.

Orthogonally targeted tumor radiosensitization using cell penetrating peptide-ATM inhibitor conjugates to stimulate anti-tumor immune responses.

[Homologous recombination repair gene variants in hormone-sensitive prostate cancer].

Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability.

DGCR8 regulates multiple processes of transcription coupled nucleotide excision repair.

RPA-independent activation of the ATR/CHK1 pathway.

Novel radiation-activated N-oxide prodrugs for highly selective and synergistic tumor therapy to promote DNA damage and the ATM/ATR pathway.

The crosstalk between chaperone-mediated autophagy and apoptosis via ATM/p53-mitochondria-dependent signaling contributed to ischemia-induced cerebral injuries.

Activation of the ATM-Chk2 DNA damage response pathway by Newcastle disease virus enhances viral replication.

ATR inhibitors: from targeting the DNA damage response to exploiting synthetic lethality-A paradigm shift in Cancer therapy.

Hypoxia facilitates triple-negative breast cancer stem cells enrichment and stemness maintenance through oxidized ataxia telangiectasia mutated-induced one-carbon metabolism.

Recent advances in small molecule ATR kinase inhibitors as anticancer agents.

Novel Ataxia Telangiectasia and Rad3-Related Protein (ATR) Phenotype: Marfanoid Appearance, Generalized Hypermobility, Gait Imbalance, and Poor Wound Healing: A Case Report.

Daxx-Dependent H3.3 Deposition Promotes Double-Strand Breaks Repair by Homologous Recombination.

Chloroquine Potentiates the Chemotherapeutic Effect of Carboplatin and ATR/Chk1 Inhibitors by Increasing the Replication Stress.

Experimental Mis-Splicing Assessment and ACMG/AMP-Guided Classification of 47 ATM Splice-Site Variants.

Prevalence and Clinical Associations of Germline DDR Variants in Prostate Cancer: Real-World Evidence from a 122-Patient Turkish Cohort.

Transcriptional Profiling Reveals Lineage-Specific Characteristics in ATR/CHK1 Inhibitor-Resistant Endometrial Cancer.

Caffeine May Delay the Radiation-Induced Nucleoshuttling of the ATM Kinase and Reduce the Recognition of the DNA Double-Strand Breaks in Human Cells.

The multifaceted role of antimicrobial peptides in neurodegeneration: Insights from Drosophila and beyond.

Ex Vivo Immuno-Oncology Platform Reveals Spatial T Cell Infiltration Patterns Linked to ATR Inhibition Responses in High-Grade Serous Ovarian Cancer.

Camonsertib, an ATRi, in Combination with Low-Dose Gemcitabine in Solid Tumors with DNA Damage Response (DDR) Aberrations: Preclinical and Phase 1b Results.

REV7 associates with ATRIP and inhibits ATR kinase activity.

Increased sensitivity of etoposide-treated breast cancer cells with an ATM inhibitor.

Call for action: misinformation about Tourette syndrome from major media network.

Germline variants in ATM, BRCA2, other cancer predisposition and novel candidate genes are implicated in glioma risk in adult glioma patients with a familial or personal history of tumors.

Loss of ATM causes R-loop-associated transcriptional dysregulation and attenuates the related response to DNA damage.

Olaparib in Patients With Solid Tumors With ATM Alterations: Results From the Targeted Agent and Profiling Utilization Registry (TAPUR) Study.

Pathway for the Development of ATR Inhibitors in Pediatric Malignancies: An ACCELERATE Multistakeholder Analysis.

Visualization and quantification of rDNA instabilities in mammalian cells and mouse models.

ATM kinase phosphorylates HSP90 on T297 changing its conformation dynamics and promoting its interaction with HER2 receptor tyrosine kinase.

HMGB1 Assists in Overcoming Cisplatin Resistance in Chemoresistant Human Ovarian Cancer Cells.

The FANCD2-FANCI heterodimer coordinates chromatin openness and cell cycle progression throughout DNA double-strand break repair.

MRE11 deacetylation by SIRT2 promotes DNA binding to facilitate DNA end resection and ATM-dependent signaling.

Genetic Regulation of DNA Double-Strand Breaks and Repair Pathways.

Recent development of ATR inhibitors for cancer therapy.

Differential roles of type I topoisomerases in regulating HPV pathogenesis.

Replication-associated base excision repair/single-strand break repair regulates PARG inhibitor response via the PRMT1/PRMT5/ATR axis.

ISG15 dysregulates endoplasmic reticulum-mitochondrial contacts and calcium homeostasis in Ataxia telangiectasia.

Translational Aspects of DNA Damage Repair in Optimizing Cancer Chemotherapy.

Progressive cerebellar ataxia with extensive peripheral telangiectasias in ataxia-telangiectasia.

Phosphoregulation for Therapeutic Interventions in Cancer? Phosphoregulatory Map of Checkpoint Kinase 1 (CHK1) Uncovers Unexplored Regulatory Layers.

Stem cell models in ataxia-telangiectasia.

Paclitaxel-Loaded Polyelectrolyte Nanocarriers: Uptake Mechanisms, Cytotoxicity, and Genotoxicity in Human Endothelial and Breast Cancer Cells.

A 10-Year-Old Boy With Ataxia-Telangiectasia: A Rare Case Report From Yemen.

Rb1 deficiency induces synthetic lethality with ATR and PKMYT1 coinhibition in breast cancer cell lines and patient-derived xenografts.

A Novel ATRIP Mutation Detected in an Iranian Family with Familial Clustering of Breast Cancer: A Case Report.

Enhanced ELL Phase Separation Is Crucial for Efficient DNA Damage Repair to Restart Transcription and Cell Survival.

A phase II, multicenter, open-label, single-arm study of berzosertib plus topotecan in patients with relapsed platinum-resistant small-cell lung cancer (DDRiver SCLC 250).

Defects in DNA damage signaling and cell cycle checkpoints in a mouse model of Rhno1 deletion.

ATM interaction with GRP94 modulates oncogenic receptor expression and signaling and microglial activation.

The ATR inhibitor tuvusertib (M1774) sensitizes prostate carcinoma to natural killer cell-mediated cytotoxicity, which is further augmented by the IL-15 receptor superagonist N-803.

TNXB modulates radiosensitivity of esophageal cancer through the ATM/P53 pathway.

RB dependent transcriptional regulation at mitotic centromeres preserves genome stability.

The efficacy and safety of ATR inhibitors in the treatment of solid tumors: a systematic review and meta-analysis.

Auranofin attenuates TOPBP1-mediated ATR replication stress response and improves chemotherapeutic response in breast tumor models.

Small intestinal SMARCA4-deficient undifferentiated carcinoma with intussusception: A case report.

Targeting synthetic lethality: an effective therapeutic approach in ovarian and endometrial cancers.

A Parent's Perspective on Systemic Gaps in Supporting Complex Pediatric Care at Home.

ATR&RNASEL germline variants: novel findings in a case of familial cancer.

NRF1-mediated innate immune response drives inflammaging.

Ferroptosis at the intersection of radiotherapy and immunotherapy.

Ataxia-telangiectasia mutated activation mediates transforming growth factor beta signaling in acetaminophen-induced liver injury in mice.

Comparative analysis of molecular targeted radiosensitizers in 2D and 3D cancer cell line models.

Ceralasertib, an ATR kinase inhibitor, as monotherapy in Japanese patients with advanced solid malignancies: Results from a phase 1 study.

Manganese mediates antiviral effects by driving an ATM -TBK1 phosphorylation signaling pathway.

NCI 10211: a phase II, single-arm study of berzosertib in combination with irinotecan in patients with advanced TP53 mutant gastroesophageal cancer.

Inhibiting sirtuin-dependent DNA repair and oxidative stress responses impairs DIPG cell survival.

Nuclear actin and DNA replication stress regulate telomere maintenance by telomerase.

Attenuation of ATM signaling by ROS delays replicative senescence at physiological oxygen.

Immunodeficiency and hemolytic uremic syndrome: a case report.

ATM promotes bone metastatic propensity of breast cancer by inducing osteoclastogenesis via the NFκB-CCL2 pathway.

Hepatitis B viral DNA integration occurs within three days of infection and is enhanced by ATR inhibition.

When the unexpected strikes: hepatocellular carcinoma in a teen with ataxia-telangiectasia.

Aurora kinase B phosphorylates ZBP1 to drive PANoptosis following treatment with PARP and ATR inhibitors combination.

Rare Genetic Variants Underlying Primary Immunodeficiency: Clinical, Pulmonary, and Genetic Insights from Two Pediatric Cases.

Clinical and molecular variations in Burkitt lymphoma.

Identifying Distinct Tourette Disorder Subtypes using Clinical Data.

TIPIN coordinates ATM-dependent checkpoint and NF-κB signaling to counteract DNA replication damage from topoisomerase inhibition.

Computational modeling of ATM signaling: a predictive framework for drug repurposing in ataxia-telangiectasia.

ATR, a DNA damage kinase, modulates DNA replication timing in Leishmania major.

ATM promotes reversed fork processing during DNA interstrand cross-link repair.

AtMCM10 facilitates SDSA-mediated intermolecular homologous recombination repair via liquid-liquid phase separation in DNA damage response.

Ataxia Telangiectasia Mutated (ATM) gene alterations as biomarkers of response to immune checkpoint inhibitors.

PARP inhibitor BMN673 triggers PARylation-mediated ATF4-GDF15 pathway to drive autophagy and ferroptosis in ataxia telangiectasia mutated gene-deficient colorectal cancer cells.

Nuclear DAB2IP regulates DNA replication initiation through activating PLK1-mediated HBO1 phosphorylation.

Beyond the nucleus: the ATM-CHEK2 axis senses mtROS to orchestrate mitophagy.

Targeting DNA Damage Repair Pathways Beyond PARP Inhibition.

E0703 targets ERβ to facilitate the upregulation of GLI3, thereby alleviating irradiation-induced DNA damage on lymphocytes.

Proteomic sensors for quantitative multiplexed and spatial monitoring of kinase signaling.

Ultra-low background radiation inhibits head and neck tumor via ATM downregulation mediated mitochondrial dysfunction.

Generation of functional noncanonical donor splice sites by +2T variants in breast cancer susceptibility genes: impact on clinical interpretation.

Feedforward miR-181d degradation modulates population variance of methyl-guanine methyl transferase and temozolomide resistance.

Recent progress in developing ATR inhibitors as anticancer agents.

Phase Ib study of berzosertib, carboplatin, gemcitabine, and pembrolizumab in patients with squamous nonsmall lung cancer (ETCTN 10313).

The Relationship Between Insulin Resistance and Cancer in Humans.

The role of ATM in sodium butyrate-mediated inhibition of macrophage polarization.

WDFY2 promotes MRN complex formation required for homologous recombination-mediated DNA repair.

Functional genomics and tumor microenvironment analysis reveal prognostic biological subtypes in Mantle cell lymphoma.

Shining light on drug discovery: optogenetic screening for TopBP1 biomolecular condensate inhibitors.

Molecular Analysis through Whole Exome Sequencing in Ataxia Telangiectasia Patients: Beyond ATM.

Dual inhibition of ATR and PARP reverses acquired PARP inhibitor resistance in triple negative breast cancer.

Melatonin inhibits ferroptosis in myocardial ischemia/reperfusion injury by inhibiting the ATM/p53 signaling pathway.

Negative feedback regulation of CHK2 in VIN18 raft cultures naturally infected with HPV18.

Targeting the ATM-TGS1-BRCA1 Axis Overcomes Genotoxic Therapy Resistance in Pancreatic Adenocarcinoma.

Characteristics of Secondary Malignancy Among Children With Primary Immunodeficiency Disorders in Saudi Arabia.

Five Years of Combined Newborn Screening Quantifying TREC and KREC in Switzerland.

Lnk deficiency enhances translesion synthesis to alleviate replication stress and promote hematopoietic stem cell fitness.

Association of DDR pathway proteins and breast cancer risk in a Pakistani population.

Defect of MLH1 expression sensitized esophageal squamous cell carcinoma cells to Polθ inhibitor.

Environmental chromium and cadmium co-exposure induces GADD45A-mediated rDNA instability in human cohorts and cell models.

Phase 1 clinical trial of the ataxia telangiectasia and Rad3-related inhibitor berzosertib with irinotecan in patients with advanced solid tumors (ETCTN 9938).

Lets talk about ataxia-telangiectasia: Meeting report of the AT clinical research conference June 2025.

H2BK120ub and its reader RNF169 sequentially regulate replication fork remodeling and stability.

Chinese herbal prescription JZ-1 enhances host resistance to herpes simplex virus type 2 through regulating the MRN-ATM-CHK2 DNA damage response.

C1orf116 inhibits acquired resistance to EGFR inhibitors in EGFR mutant lung adenocarcinoma by suppressing the ATM/ATR pathways.

Diversity of oxidative stress and senescence phenotypes induced by chemotherapeutic agents in HUVECs.

Alpha-ketoglutarate mitigates insulin resistance and metabolic inflexibility in a mouse model of Ataxia-Telangiectasia.

Phosphorylation of RNF213 by ATM-mediated ubiquitination of RPA1 regulates homologous recombination repair and chemosensitivity.

TopBP1 biomolecular condensates as a new therapeutic target in advanced-stage colorectal cancer.

ZDHHC20-mediated S-palmitoylation of KAP1/TRIM28 promotes DNA damage repair.

Intractable thrombocytopenia in a patient with atypical ataxia-telangiectasia: a case report.

The ATR Inhibitor Elimusertib in Combination with Cisplatin in Patients with Advanced Solid Tumors: A California Cancer Consortium Phase I Trial (NCI 10404).

Ataxia-Telangiectasia in Resource-Limited Settings: A Diagnostic Challenge.

Senataxin promotes recombination fidelity during antigen receptor gene diversification.

Impact of SAMHD1 and phosphorylated ATM levels on the progression and prognosis of patients with soft tissue sarcoma.

Differential expression of a disease-associated MRE11 variant reveals distinct phenotypic outcomes.

Targeting the ATM-TRMT10A-BRCA1 axis confers synthetic lethality to PARP inhibition in metastatic castration-resistant prostate cancer.

Pathogenic Variants, Family History, and Cumulative Risk of Breast Cancer in US Women.

Mapping the non-coding RNA landscape in ataxia telangiectasia: a scoping review of ATM dependent miRNA and lncRNA dysregulation.

Prolactin and DNA damage trigger an anti-breast cancer cell immune response.

Allium sativum lectin as an immunotherapeutic agent: Eliciting IFN-γ production via "M1" macrophage polarization to trigger JAK1/STAT1 and DDR mediated lung cancer cell death.

Quantitative digital pathology reveals morphological and molecular correlates of tumor aggressiveness in prostate cancer.

Anti-colorectal cancer bioactive metabolites from endophytic fungi of Pyrola spp. targeting p-ATM/P53 pathway driven by in vitro experiments and network pharmacology.

Modelling-filtered drug repurposing and first-in-protein SPR validation of histone deacetylase 4 inhibitors for Ataxia-telangiectasia.

Expanding the clinical spectrum of pediatric ataxia-telangiectasia: a case series of novel genetic variants, lupus vulgaris, and hyper-IgM phenotypes.

Cell death mechanisms induced by gold nano-immunoconjugates-mediated photodynamic therapy against human oesophageal cancer stem cells.

IFI16 Enhances Chemosensitivity of Breast Cancer Cells by Inhibiting DNA Damage Response.

Nucleolar stress facilitates islet β cell senescence via hijacking the DNA damage response pathways.

Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway.

Fundamental prognostic difference of ATM gene mutation and deletion in newly diagnosed mantle cell lymphoma.

Orthopedic manifestations of ataxia telangiectasia in children.

Mortality rate and causes of death in inborn errors of immunity: A systematic review and meta-analysis.

DNA Damage and Repair in Ovarian Cancer: Focus on MicroRNAs.