Neoplasia mieloproliferativa crônica caracterizada pela expressão do gene de fusão BCR-ABL1. Apresenta leucocitose neutrofílica. Pode aparecer em qualquer idade, mas afeta principalmente indivíduos de meia idade e mais velhos. Os pacientes geralmente apresentam fadiga, perda de peso, anemia, sudorese noturna e esplenomegalia. Se não for tratada, segue um curso natural bifásico ou trifásico; uma fase crônica indolente inicial que é seguida por uma fase acelerada, uma fase blástica ou ambas. O transplante alogênico de células-tronco e os inibidores da tirosina quinase atrasam a progressão da doença e prolongam a sobrevida global.
Introdução
O que você precisa saber de cara
Neoplasia mieloproliferativa crônica caracterizada pela expressão do gene de fusão BCR-ABL1. Apresenta leucocitose neutrofílica. Pode aparecer em qualquer idade, mas afeta principalmente indivíduos de meia idade e mais velhos. Os pacientes geralmente apresentam fadiga, perda de peso, anemia, sudorese noturna e esplenomegalia. Se não for tratada, segue um curso natural bifásico ou trifásico; uma fase crônica indolente inicial que é seguida por uma fase acelerada, uma fase blástica ou ambas. O transplante alogênico de células-tronco e os inibidores da tirosina quinase atrasam a progressão da doença e prolongam a sobrevida global.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 8 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 15 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
3 genes identificados com associação a esta condição. Padrão de herança: Not applicable.
Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:17116687, PubMed:1903516, PubMed:7479768). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modul
Postsynaptic densityCell projection, dendritic spineCell projection, axonSynapse
Leukemia, chronic myeloid
A clonal myeloproliferative disorder of a pluripotent stem cell with a specific cytogenetic abnormality, the Philadelphia chromosome (Ph), involving myeloid, erythroid, megakaryocytic, B-lymphoid, and sometimes T-lymphoid cells, but not marrow fibroblasts.
Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, inc
Nucleus
Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENA
Cytoplasm, cytoskeletonNucleusMitochondrionNucleus membrane
Leukemia, chronic myeloid
A clonal myeloproliferative disorder of a pluripotent stem cell with a specific cytogenetic abnormality, the Philadelphia chromosome (Ph), involving myeloid, erythroid, megakaryocytic, B-lymphoid, and sometimes T-lymphoid cells, but not marrow fibroblasts.
Medicamentos aprovados (FDA)
2 medicamentos encontrados nos registros da FDA americana.
Variantes genéticas (ClinVar)
684 variantes patogênicas registradas no ClinVar.
Classificação de variantes (ClinVar)
Distribuição de 6 variantes classificadas pelo ClinVar.
Vias biológicas (Reactome)
41 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Leucemia mieloide crônica
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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
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Outros ensaios clínicos
Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 7.544
Safety and Efficacy of Flumatinib in Patients with Chronic Phase Chronic Myeloid Leukemia: A Real-Life Cohort Observational Study.
This study aims to comprehensively evaluate the safety and effectiveness of flumatinib in both first-line and subsequent-line therapies in 244 chronic-phase chronic myeloid leukemia (CML-CP) patients. Response criteria were applied according to the European LeukemiaNet. Adverse events (AEs) occurring after flumatinib treatment were documented and graded for severity. The study encompassed 244 patients with CML-CP, stratified by treatment lines: first-line (1L, N=138), second-line (2L, N=63), and third-line or above (≥3L, N=43). First-line flumatinib therapy resulted in a major molecular response achieved by 50.7% at 6 months and 66.7% at 12 months, with a deep molecular response (DMR) achieved by 20.3% at 6 months and 35.5% at 12 months. In subsequent treatment lines, those with baseline MR2 had a DMR rate of 42.9%, compared to 23.3% for those without it. Significant differences in molecular response rates were observed based on treatment line and prior tyrosine kinase inhibitors (TKI) resistance (p<0.05). However, subgroup analyses showed no significant differences in treatment responses between the warning and resistance groups after flumatinib therapy. Dose reduction strategies, implemented in 19.3% of patients, have proven feasible without compromising efficacy. Eight patients subsequently attempted treatment cessation, with five maintaining treatment-free remission. AEs were predominantly grade 1-2, with diarrhea (27.0%), fatigue (12.3%), and thrombocytopenia (11.5%) being the most frequent. Grade 3/4 AEs were infrequent, highlighting flumatinib's manageable safety profile. Flumatinib displays significant clinical efficacy and a superior safety profile compared to other second-generation TKI, whether administered in first-line or subsequent treatment settings.
Transcriptional readthrough precedes alternative splicing programs triggered in CML cells by imatinib.
Cellular stresses regulate transcriptional readthrough, whereby RNA polymerase II elongates past a gene's polyadenylation cleavage site without RNA cleavage. Readthrough has been reported in several cancer types. Here, we use long-read sequencing of nascent RNA to quantify transcriptional readthrough in chronic myeloid leukemia (CML) cells and characterize early responses to the targeted therapeutic, imatinib. We show that the amount, length, and gene specificity of readthrough increase within 1 hour, before gene expression and alternative splicing alterations emerge. Notably, imatinib-dependent messenger RNA (mRNA) isoform changes involved "readthrough chimeras," in which exons from an upstream gene are alternatively spliced to exons in a downstream gene. Altered mRNA isoforms and chimera levels were detected in imatinib-resistant K562 cells as well as cells of patients with CML. Thus, imatinib can provoke a cascade of early changes to transcription and splicing fidelity that may lead to longer-term adjustments in gene expression, cancer cell differentiation, and the development of therapy resistance.
FBXO3-mediated DUSP9 ubiquitination promotes leukemia stem cell maintenance and tyrosine kinase inhibitor resistance in chronic myeloid leukemia.
Eradicating leukemia stem cells (LSCs) and overcoming tyrosine kinase inhibitor (TKI) resistance is urgent for chronic myeloid leukemia (CML) treatment. We find that F-box protein 3 (FBXO3) is highly upregulated in CD34+ CML stem cells from TKI-resistant patients and identify it as an innovative CML-LSC marker via single-cell RNA sequencing (scRNA-seq). FBXO3 deficiency induces apoptosis and reduces proliferation of CML cell lines and LSCs in vitro and in vivo, with minimal effects on normal CD34+ hematopoietic stem cells (HSCs). Mechanistically, FBXO3 interacts with DUSP9 to promote its ubiquitination and activate the MAPK pathway, critical for CML cell activity. DUSP9 knockdown partially reverses FBXO3-deficiency-mediated LSC elimination. Furthermore, FBXO3 inhibitor monotherapy or combination with imatinib effectively eradicates CML-LSCs, overcomes TKI resistance, and spares normal hematopoiesis. Collectively, our findings highlight FBXO3's role in CML progression and support combining FBXO3 inhibitors with TKIs for durable LSC elimination.
Nonclassical Philadelphia-positive FISH signal patterns in CML and seven cases with variant Philadelphia.
Chronic myeloid leukemia (CML) is characterized by the Philadelphia chromosome (Ph), which occurs as a result of t(9;22). In 5%-10% of CML cases, variant t(9;22)s are observed. Additionally, while t(9;22) is formed, deletions can be observed in chromosomes 9 and 22. These deletions are observed more frequently in variant t(9;22). There is conflicting information in the literature about the prognostic effects of variant t(9;22) and deletions of 9q and 22q. There is also limited information about the frequency and breakpoints of other chromosomes involved in the variant t(9;22). Signal patterns other than the classical signal pattern of FISH analysis indicate deletions and variant translocations. In this study, we aimed to investigate the clinical significance of nonclassical FISH signal patterns and to determine the frequency of variant translocations. Bone marrow samples from 231 newly diagnosed CML patients were analyzed by conventional cytogenetics and FISH. As a result of FISH analysis, nonclassical FISH signal patterns were detected in 49/231 cases, and variant t(9;22) was detected in seven cases by conventional cytogenetics. It was determined that chromosomes 1, 3, 5, 7, 8, and 21 were involved in variant t(9;22). When cases with classical and nonclassical signal patterns were compared in terms of 6th- and 12th-month treatment responses, survival times, and treatment changes, it was found that cases with classical signal patterns had significantly higher treatment responses at the 6th month (p < 0.001). Because variant translocations are extremely rare and involve many different chromosomal breaks, a large number of cases are needed to clearly understand their prognostic implications. Due to the limitations of conventional cytogenetic analyses, it should be considered in patient follow-up that nonclassical FISH signal patterns indicating deletions and/or variant translocations may cause a delay in obtaining a complete cytogenetic response at the 6th month.
From mutational signatures to practice: Artificial intelligence-guided repurposing for blast crisis chronic myeloid leukemia.
This article of discusses blast crisis chronic myeloid leukemia (CML), which is the most aggressive CML phase marked by rapid progression, substantial mutational complexity, and resistance to standard tyrosine kinase therapies. The methodology combines whole exome sequencing and machine learning to identify the molecular subtypes of blast crisis-CML and repurpose existing Food and Drug Administration-approved drugs on the basis of the Catalogue of Somatic Mutations in Cancer mutational patterns. In a pilot cohort (n = 7), three exploratory genomic clusters were identified: Breast cancer gene 2/tumor protein p53; isocitrate dehydrogenases (IDH) 1 and IDH 2 ten eleven translocation 2; and Janus kinase (JAK) 2/colony stimulating factor 3 receptor. The results present an opportunity to evaluate poly(ADP ribose) polymerase inhibitors (breast cancer gene 2/tumor protein p53), IDH inhibitors (IDH1/2 or ten eleven translocation 2), and JAK inhibitors (JAK2 or colony stimulating factor 3 receptor) as actionable therapeutics. Moreover, this e article presents as a strategic framework for mutation-targeted therapy targeting treatment-resistant leukemias, highlighting the potential of artificial intelligence-driven molecular stratification and uncovering clinically relevant therapeutic options for malignancies. However, limitations should be acknowledged, such as the limited cohort size and the necessity for validation in larger multicenter investigations. Prospective registries and trial enrollment should test signature-defined micro-cohorts with versioned and auditable reporting. These mappings are designed to provide hypotheses and depend on independent functional validation, prioritizing safety in combination methods with tyrosine kinase inhibitors, and allows for practical implementation in rapid turnaround environments.
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Safety and Efficacy of Flumatinib in Patients with Chronic Phase Chronic Myeloid Leukemia: A Real-Life Cohort Observational Study.
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Frontiers in oncologyHyperoside impairs mitochondrial respiration in chronic myeloid leukemia by promoting STUB1-mediated ubiquitination and degradation of NOX4.
Toxicology and applied pharmacologyShared Identity and Patient Care: Adherence to Guideline-Recommended Biomarker Testing in Chronic Myeloid Leukemia.
Journal of the National Comprehensive Cancer Network : JNCCNChronic Myeloid Leukemia (CML): historical perspective, pathophysiology, and treatment advances.
Acta haematologica[New ways in interdisciplinarity: internal medicine meets human genetics : When frequent conditions become rare and rare conditions become frequent].
Innere Medizin (Heidelberg, Germany)Management of chronic myeloid leukemia with tyrosine kinase inhibitors: adverse events, toxicities and therapy dosing.
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Biochimica et biophysica acta. General subjectsFrom mutational signatures to practice: Artificial intelligence-guided repurposing for blast crisis chronic myeloid leukemia.
World journal of clinical oncologyOlverembatinib-Based Therapy in Patients With Transformed Chronic Myeloid Leukemia in Lymphoid Blast Phase or Relapsed or Refractory Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: A Multicenter Retrospective Study.
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Turkish journal of chemistryUnderreported and underreviewed: Addressing the gaps in TKI tolerability literature for chronic myeloid leukemia.
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International journal of oncologyCase Report: Co-existence of BCR::PDGFRA gene fusion and PDGFRA variants in myeloid neoplasm with persistent leukocytosis, large splenomegaly, and eosinophilia.
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BMJ case reports[The challenge of achieving treatment-free remission for chronic myeloid leukemia].
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[Rinsho ketsueki] The Japanese journal of clinical hematology[Key points in second-line therapy for chronic myeloid leukemia].
[Rinsho ketsueki] The Japanese journal of clinical hematology[Key points in selecting first-line therapy for chronic myeloid leukemia].
[Rinsho ketsueki] The Japanese journal of clinical hematologyBCR::ABL1 Mutational Profiling in US Patients With Chronic-phase Chronic Myeloid Leukemia on Tyrosine Kinase Inhibitors.
Cancer diagnosis & prognosisThe oncogenic role of ecotropic viral integration site 1 in hematological malignancies: mechanisms of activation and leukemogenesis.
Frontiers in immunologyDifferentially expressed proteins in plasma-derived extracellular vesicles from chronic myeloid leukemia patients.
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Clinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaPotential utility of PPARγ agonists in targeting chronic myeloid leukemia stem cells.
Annals of hematologySecondary Chronic Myeloid Leukemia in the Blast Phase With Mixed Phenotype After Radiation Therapy: A Case Report.
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Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood TransfusionIs asciminib an effective tyrosine kinase inhibitor for chronic myeloid leukemia patients with tyrosine kinase inhibitor resistance?
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International journal of analytical chemistryHyperleukocytosis in a Patient With Chronic Myeloid Leukemia and HIV: A Case Report.
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Therapeutic advances in hematologyConvergent Multistage Evidence Implicates the CCR2-Artemin Immune-Inflammation Axis in Acute Myeloid Leukemia.
Mediators of inflammation[Relapse of chronic myeloid leukemia presenting with blurred vision after allogeneic hematopoietic stem cell transplantation].
[Rinsho ketsueki] The Japanese journal of clinical hematologyAn ultrasensitive FEN1-aided LCR-electrochemical biosensor enables detection of BCR/ABL1 fusion transcripts in clinical samples for early diagnosis and minimal residual monitoring of CML.
Biosensors & bioelectronicsDistribution of ABO/Rh Blood Types Across Childhood Leukemia Subtypes: A Retrospective Cohort Study of 540 Pediatric Patients.
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Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical ImmunologyProlonging the anti-tumor effects of cold atmospheric plasma via exosome-mediated signaling.
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CancerChronic Myeloid Leukemia as a Secondary Malignancy in a Child Treated for T Cell Acute Lymphoblastic Leukemia.
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Molecular biology reportsTreatment-free remission after two nilotinib consolidation durations in chronic myeloid leukemia treated with imatinib: Phase 3 ENESTPath results.
LeukemiaInfluence of pharmacokinetics-related polymorphisms on asciminib exposure in patients with Japanese chronic myeloid leukemia.
European journal of clinical pharmacologyDasatinib-Associated Recurrent Symptomatic Bilateral Pleural Effusions in an Elderly Patient With End-Stage Renal Disease on Maintenance Hemodialysis.
CureusOlverembatinib (HQP1351): a third-generation tyrosine kinase inhibitor in the treatment of hematologic and solid malignancies-a comprehensive review of clinical outcomes.
Discover oncologyA Framework for Locally Imputing and Predicting Biomarker Trajectories Under Irregular Monitoring: Application to Chronic Myeloid Leukemia.
Research squarePonatinib for CML patients in routine clinical practice: the PONDEROSA study.
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Theory in biosciences = Theorie in den BiowissenschaftenAssessing trends in conditional survival for non-Hodgkin lymphoma and chronic myeloid leukemia via novel extensions to the joinpoint survival model.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive OncologyAn Overview of Chronic Myeloid Leukemia Treatment: From Tyrosine Kinase Inhibitors to Novel and Emerging Therapies.
European journal of haematologyRandomized phase 3 trial of Ropeginterferon alfa-2b versus surveillance after tyrosine kinase inhibitor discontinuation in chronic myeloid leukemia (ENDURE/CML-IX).
Leukemia[Extramedullary blast crisis limited to the lymph nodes in chronic myeloid leukemia with a T/myeloid mixed phenotype].
[Rinsho ketsueki] The Japanese journal of clinical hematologyEvaluating the Safety of Combining Tyrosine Kinase Inhibitors with Anticoagulants in Chronic Myeloid Leukemia: A Systematic Review.
OncologyLeukemia epidemiology in China: Burden, trends, and determinants in the 21st century.
Chinese journal of cancer research = Chung-kuo yen cheng yen chiuImpact of Bone Marrow Fibrosis on the Outcome of Chronic Myeloid Leukemia Treated with Second Generation Tyrosine Kinase Inhibitors.
Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood TransfusionHypoxic conditions confer chemoresistance to crizotinib but not to imatinib in chronic myeloid leukemia cells.
Hematology, transfusion and cell therapyCorrigendum to "Aleukemic Chronic Myeloid Leukemia Without Neutrophilia and Thrombocytosis: A Report From the BCR::ABL1 Pathology Group" [Modern Pathology. 2024;37(2):100406].
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, IncA selenium-containing selective estrogen receptor modulator to overcome drug resistance of chronic myeloid leukemia.
Apoptosis : an international journal on programmed cell deathTrilineage Extramedullary Hematopoiesis in Pleural Effusion: A Rare Phenomenon.
Diagnostic cytopathologyReal-World Outcomes With Low-Dose Dasatinib (50 mg) in Imatinib-Resistant Chronic Myeloid Leukemia in Chronic Phase: A Retrospective Analysis of Efficacy and Safety.
Cancer reports (Hoboken, N.J.)[Total flavonoids from Sarcandra glabra promote apoptosis in leukemia K562 cells via sphingolipid metabolism and PI3K/Akt signaling pathway based on cellular metabolomics].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medicaBiological Features of KLC2 Mutations in Chronic Myeloid Leukemia and Their Contribution to Inducing Drug Resistance.
Oncology researchMPN-FIT: a randomized controlled pilot trial of supervised exercise in myeloproliferative neoplasms.
Blood advancesSpecifically targeting the ABL myristoyl pocket: STAMP inhibitors for chronic myeloid leukemia.
Expert review of hematologyAssociation of fibronectin 1 deregulation with tyrosine kinase inhibitor resistance in chronic myeloid leukemia.
Frontiers in cell and developmental biologyLigand Valency and Linker Design Dictate the Efficacy of CI-M6PR-Mediated Targeted Delivery of M6P-siRNA Conjugates.
ACS omega[Guideline for the diagnosis and treatment of chronic myeloid leukemia in China (2025)].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhiCaffeic acid phenethyl ester induced apoptosis in chronic myeloid leukemia cells by inhibiting mitochondrial complex I.
Scientific reportsIntersection of Tyrosine Kinase Inhibition and Sepsis-Induced Cardiomyopathy.
Case reports in pathologyTyrosine Kinase Inhibitors as Risk Factors for Cerebral Vascular Disease: Report of Two Cases and Literature Review.
Case reports in neurological medicineBMP-7 Treatment Ameliorates PTEN-Akt Mediated Apoptosis and Adverse Cardiac Remodeling in Ponatinib-Induced Cardiotoxicity.
Pharmaceuticals (Basel, Switzerland)MUTATIONAL STATUS AND TREATMENT EFFICACY IN PATIENTS WITH CHRONIC MYELOID LEUKEMIA.
Problemy radiatsiinoi medytsyny ta radiobiolohiiBCR::ABL1 kinase domain mutations and their predictive value for treatment outcomes in patients with chronic myeloid leukemia treated with first-line imatinib in a low-income setting: Experience from Côte d'Ivoire.
Leukemia research reportsBone Marrow Edema and Tyrosine Kinase Inhibitors Treatment in Chronic Myeloid Leukemia.
Diagnostics (Basel, Switzerland)Early BCR::ABL1 Reduction as a Predictor of Deep Molecular Response in Pediatric Chronic-Phase Chronic Myeloid Leukemia.
CancersNeuropsychiatric Symptoms Mimicking Dementia in a Patient Treated With Imatinib.
Annals of clinical and translational neurologyWhat is the role of asciminib in chronic myeloid leukemia?
Clinical advances in hematology & oncology : H&OAddressing unmet needs in chronic myeloid leukemia in chronic phase treated with two or more tyrosine kinase inhibitors: insights from literature and Indian clinical practice.
Expert review of hematologyHsp70-Bim interaction mediated mitophagy as a potential therapeutic target for CML stem cells.
Stem cell reportsInterindividual variability in imatinib metabolism in human liver microsomes and primary human hepatocytes: Impact of CYP2C8 and CYP3A phenotypes.
Drug metabolism and disposition: the biological fate of chemicalsUSP8-EIF2S1 signaling enhances CML cell survival under TKI-induced stress.
The FEBS journalA Case of Synchronous Primary Pancreatic DLBCL and Incipient CML.
Journal of the Association of Genetic TechnologistsPrevalence of Chronic Myeloid Leukemia in the United States: A Cross-Sectional Study Using the SEER Database.
South Asian journal of cancerEfficacy and safety of flumatinib in adults with Ph-positive ALL: a prospective observational study.
Frontiers in oncologyIntestinal low-abundant bacteria drive MyD88/Trif-dependent CD8+ T cell exhaustion in chronic myeloid leukemia.
Cell reportsExtracellular vesicles-derived non-coding RNA in leukemias and pre-leukemic syndromes: a systematic review.
Journal of cancer research and clinical oncologyBehcet's disease in a patient with chronic myeloid leukemia.
Indian journal of sexually transmitted diseases and AIDSExosome and BCR-ABL mediated molecular alterations in endothelial cells in chronic myeloid leukemia: identification of seven genes and their regulatory network.
PeerJp38 MAPK-mediated suppression of Nrf2-MPC2 axis drives metabolic reprogramming which confers imatinib resistance in blast crisis phase of chronic myeloid leukemia.
Experimental cell researchExploring phytochemical inhibitors of fatty acid elongase ELOVL6 for targeted treatment of chronic myeloid leukemia: A comprehensive network-based drug discovery approach.
Computers in biology and medicineImmune Surveillance in Chronic Myeloid Leukemia: Tumor Antigen Expression and CD8+ T Cell Function in the Context of Treatment- Free Remission.
Archivum immunologiae et therapiae experimentalisTreatment expectations and goals among patients with chronic myeloid leukemia in Germany: a patient-centered perspective.
LeukemiaTargeting myeloid cell leukemia-1 protein to identify potential compounds for chronic myeloid leukemia treatment: Molecular docking and molecular dynamics simulation approaches.
Biochemical and biophysical research communicationsInnate CD8 T-cells as a potential predictive biomarker for deep molecular response in chronic myeloid leukemia patients.
Cancer immunology, immunotherapy : CIIIdentification of N-tert-butyloxycarbonyl protected amino acids as novel hydrophobic tags to induce targeted protein degradation.
European journal of medicinal chemistryReal-world efficacy and adverse events of frontline nilotinib in pediatric chronic myeloid leukemia in chronic phase: A prospective multicenter study from SCCCG[PLUS]-CML 2023.
CancerThe role of the bone marrow microenvironment in leukemic stem cell resistance: Pathways of persistence and selection.
Critical reviews in oncology/hematologyHigher HLA-DRB1 Evolutionary Divergence Is Associated with Reduced Relapse and Improved Survival after Matched Unrelated Hematopoietic Cell Transplantation.
Transplantation and cellular therapyAsciminib Demonstrates Superior Efficacy and Safety in Newly Diagnosed Chronic Myeloid Leukemia in the ASC4FIRST Trial.
BloodSingle-cell disentangled representations for perturbation modeling and treatment effect estimation.
bioRxiv : the preprint server for biologyReshape memory T cell landscape in CML patients' blood by tyrosine kinase inhibitors.
Caspian journal of internal medicineDiagnosis, treatment, and monitoring of cytomegalovirus pneumonia in a hematopoietic stem cell transplantation child.
Frontiers in cellular and infection microbiologySimultaneous chromatographic quantification of upadacitinib, nilotinib, and tryptophan decoding myeloid leukemia and liver cancer integrated with ELISA and Flow cytometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciencesDevelopment of a blood test-based predictive scoring tool for treatment response in chronic myeloid leukemia.
International journal of hematologyDisarming the Hsp70-Bim Alliance: Small-Molecule and Peptidic Disruptors of a Chaperone-Apoptotic Switch in Cancer.
ChemistryOpenGenetic Variations in BCL3, MDM4, KLF14, and miR-146a and Their Associations with the Predisposition and Progression of Myeloproliferative Disorder and Chronic Myeloid Leukemia Patients.
Molecular syndromologyAtypical chronic myeloid leukemia: From diagnosis to molecular features and therapeutic options.
HemaSphereImproving quality of life for patients with chronic myeloid leukemia through supportive care, low-dose therapy, switching, and treatment-free remission.
HaematologicaIs there a best frontline therapy in chronic myeloid leukemia?
HaematologicaCombined asciminib and olverembatinib in blast-phase chronic myeloid leukemia.
HaematologicaNCIVISION: A Siamese Neural Network for Molecular Similarity Prediction MEP and RDG Images.
Molecules (Basel, Switzerland)Identification of a Novel miR-122-5p/CDC25A Axis and Potential Therapeutic Targets for Chronic Myeloid Leukemia.
International journal of molecular sciencesChronic Myeloid Leukemia and the T315I BCR::ABL1 Mutation.
International journal of molecular sciencesIdentification and characterization of peptidyl-prolyl isomerase Pin1 as a new regulatory component of BCR::ABL1 degradation.
Leukemia researchPeripheral blood CD26+ leukemic stem cells in chronic myeloid leukemia and tyrosine kinase inhibitor response: Questions remain!
CancerHeterocyclic Compounds as Bcr-Abl Tyrosine Kinase Inhibitors Against Chronic Myeloid Leukemia.
Medicinal chemistry (Shariqah (United Arab Emirates))Do genetic polymorphisms influence imatinib trough concentrations in patients with chronic myeloid leukemia? A systematic review and meta-analysis.
Expert review of anticancer therapyOlverembatinib for 8p11 myeloproliferative syndrome with a positive BCR-FGFR1 fusion gene: a case report.
Annals of hematologyInvestigating chronic myeloid leukemia therapeutics: AI-optimized design and synthesis of 4-methylthiazole-2-amine derivatives with translocation control activity.
RSC advancesOmics and artificial intelligence integration for stratifying blast crisis CML using COSMIC signatures and pan-cancer precision drug repurposing.
World journal of clinical oncologyAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Safety and Efficacy of Flumatinib in Patients with Chronic Phase Chronic Myeloid Leukemia: A Real-Life Cohort Observational Study.
- Transcriptional readthrough precedes alternative splicing programs triggered in CML cells by imatinib.
- FBXO3-mediated DUSP9 ubiquitination promotes leukemia stem cell maintenance and tyrosine kinase inhibitor resistance in chronic myeloid leukemia.
- Nonclassical Philadelphia-positive FISH signal patterns in CML and seven cases with variant Philadelphia.
- From mutational signatures to practice: Artificial intelligence-guided repurposing for blast crisis chronic myeloid leukemia.
- Multifocal Posterior Pigment Epitheliopathy Complicated by Circumferential Choroidal Detachment Treated With Fluorescein Angiography-Guided Focal Laser Photocoagulation: A Case Report.
- Case Report: Chronic myeloid leukemia in a 13-year-old-a rare pediatric case of extreme hyperleukocytosis in chronic phase.
- Concurrent SF3B1 Mutation and BCR::ABL1 Demonstrating a Myelodysplastic Syndrome Phenotype: A Case Report.
- [Variables associated with severe cytopenia in adult chronic phase chronic myeloid leukemia patients receiving initial tyrosine kinase inhibitors].
- An unusual case of basophilic meningitis revealing a chronicphase chronic myeloid leukemia: a report after almost three years of follow-up.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:521(Orphanet)
- OMIM OMIM:608232(OMIM)
- MONDO:0011996(MONDO)
- GARD:6105(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
- Q729735(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
