Prolactinoma é um tipo de tumor geralmente benigno que se forma na glândula hipófise e causa um excesso de prolactina no sangue. Os sintomas mais comuns são: em mulheres, a ausência de menstruação e a dificuldade para engravidar; e, em homens, a dificuldade de ereção, a diminuição do desejo sexual e a dificuldade para ter filhos.
Introdução
O que você precisa saber de cara
Prolactinoma é um tipo de tumor geralmente benigno que se forma na glândula hipófise e causa um excesso de prolactina no sangue. Os sintomas mais comuns são: em mulheres, a ausência de menstruação e a dificuldade para engravidar; e, em homens, a dificuldade de ereção, a diminuição do desejo sexual e a dificuldade para ter filhos.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 25 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 50 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
3 genes identificados com associação a esta condição. Padrão de herança: Autosomal dominant.
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for norma
Cell membrane
Usher syndrome 1D
USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa with sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness.
Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates
Nucleus
Familial multiple endocrine neoplasia type I
Autosomal dominant disorder characterized by tumors of the parathyroid glands, gastro-intestinal endocrine tissue, the anterior pituitary and other tissues. Cutaneous lesions and nervous-tissue tumors can exist. Prognosis in MEN1 patients is related to hormonal hypersecretion by tumors, such as hypergastrinemia causing severe peptic ulcer disease (Zollinger-Ellison syndrome, ZES), primary hyperparathyroidism, and acute forms of hyperinsulinemia.
May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation
Mitochondrion matrixNucleus
Variantes genéticas (ClinVar)
2,365 variantes patogênicas registradas no ClinVar.
Vias biológicas (Reactome)
13 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Prolactinoma
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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
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31 ensaios clínicos encontrados, 5 ativos.
Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 1.235
The Spectrum of Serum Prolactin Levels in Patients with Non-Functioning Sellar Masses: A Retrospective Analysis.
Differentiating prolactinomas from non-functioning sellar masses causing hyperprolactinemia due to stalk effect is a common diagnostic challenge. While both can result in elevated serum prolactin, accurate discrimination is essential for appropriate management. To determine the upper limit of serum prolactin in non-functioning sellar masses attributable to stalk effect. This retrospective study was conducted at a tertiary care center in South India from January 2015 to December 2024. Patients with both non-pituitary sellar masses and pituitary tumors with negative prolactin immunohistochemistry were included. Patients with functioning pituitary adenomas, hyperprolactinemia-inducing drugs, chronic kidney disease, severe hepatic dysfunction, and PCOS were excluded. The primary objective was to determine the upper limit of serum prolactin levels attributable to stalk effect in patients with non-functioning sellar masses. Preoperative serum prolactin levels were measured using a chemiluminescent immunoassay. The 97th percentile value was taken as the upper limit. Of 288 cases of non-functioning sellar masses, 57 met inclusion criteria. Most of them (87.7%, 50/57) were >1 cm, with 68% (39/57) classified as pituitary adenomas-49% (19/39) being gonadotroph adenomas and 41% (16/39) null cell adenomas. Hyperprolactinemia was observed in 32% of patients. The median serum prolactin level was 14.8 ng/mL, and the 97th percentile was 70 ng/ml. No significant correlation was found between tumor size and serum prolactin level (r = 0.13, P = 0.35). Gender did not significantly affect serum prolactin levels. A serum prolactin threshold of 70 ng/mL was identified, above which non-functioning sellar masses are highly unlikely. In patients with non-functioning sellar masses, serum prolactin levels rarely exceed 70 ng/ml. This threshold may serve as a useful diagnostic marker to distinguish stalk effect from prolactinomas. Prospective validation in larger cohorts is warranted.
A novel germline CDH23 variant as a likely cause of an ultra-giant prolactinoma.
Giant prolactinomas are defined as pituitary adenomas (PAs) ≥ 4 cm with plasma prolactin level > 1000 ng/ml with no other co-secretory component. The reasons for development of giant prolactinomas are not clear but genetics play an important pathogenic mechanism in some PAs. In this report, we describe a middle-aged woman who incidentally was found to have an infiltrative giant prolactinoma involving the sellar, supra- and parasellar regions and occupying most of the middle fossae of the skull extending all the way to the occipital and upper cervical regions. Anteriorly, it extends to the sphenoid and parasellar sinuses, nasopharynx and nasal cavities. It was initially thought to be a nasopharyngeal cancer but biopsy from a protruding component from the right nostril showed that it was a prolactinoma. Prolactin level after several dilutions was extremely high at 277,500 ng/ml (normal range 3.4–24.1 ng/ml). Surprisingly, her pituitary function evaluation showed only mild central hypothyroidism [(FT4 11.4 pmol/l (normal range 12–22) and TSH 1.9 mU/l (normal range 0.27–4.2)] and hypogonadotropic hypogonadism (E2 47 pmol/l, LH 1.9 u/l, FSH 5.9 u/l). Cosyntropin stimulation test was normal suggesting normal pituitary adrenal axis but insulin-induced hypoglycaemia test was not performed. In retrospect, the patient reported chronic nasal congestion and snoring, headaches on/off and deterioration in her hearing and visual acuity over the last few years. She ascribed these symptoms to sinusitis and advancing age, respectively. Whole exome sequencing revealed a novel variant in CDH23 (NM_022124.6:c.2621C > A, p.Ala874Asp), a gene that has been previously reported to be associated with PAs. The patient was treated with small doses of cabergoline (0.5 mg twice weekly) and reported remarkable improvement in her symptoms. Radiological evaluation confirmed the significant response of this giant prolactinoma to cabergoline.
Prolactinoma in males: a single center experience in Northern Africa.
Male prolactinoma remains a singular entity. Our study represents the first reported experience of male prolactinoma in Northern Africa. Our work aimed to characterize prolactinomas in the male population, an entity known for its aggressive features, and also to highlight the specific challenges encountered in a North African clinical context. This is a retrospective descriptive study of male patients presenting with prolactinoma at the endocrinology, diabetology and nutrition department of a university hospital center over a 10-year period. The mean age at diagnosis was 37 ± 11 years. Mass effect related symptoms were present in 83% of cases. Decreased visual acuity was found in 60% of cases. Galactorrhea was found in 13% of cases, decreased libido in 60% of cases, and gynecomastia in 20% of cases. At the time of diagnosis, the mean prolactin level was 4,685 ng/ml (79-33,000). All patients had hypogonadotropic hypogonadism. Among our patients, 66% had undergone dopaminergic agonists as monotherapy, and pituitary surgery was performed in 33% of cases in conjunction with dopaminergic agonists. After a 30-month average follow-up, medical treatment achieved prolactin control in 83% of cases and tumor shrinkage in 70%, while surgery achieved prolactin control in 85% and tumor shrinkage in 70% of cases. Prolactinoma in men is usually invasive and of considerable volume, putting patients at risk of mass effect related symptoms, especially ophthalmologic complications. Hence the importance of early, multidisciplinary and personalized management.
Familial prolactinomas.
Prolactinomas are among the most common pituitary tumours, with a small but clinically significant subset occurring on a familial or inherited basis. This review examines the spectrum of genetic conditions associated with familial prolactinoma, including both isolated familial forms and complex syndromic disorders. The clinical features that should raise suspicion for an underlying genetic predisposition are outlined, along with the appropriate steps for genetic evaluation and counselling. The implications of a genetic diagnosis for both the management of the individual patient and the screening of at-risk family members are highlighted. Through the integration of genetics into clinical practice, a more personalized and preventive approach to the care of patients with prolactinomas and their families can be achieved.
The clinical value of [18F]-fluoro-ethyl-L-tyrosine PET ([18F]FET-PET) correlated with MRI in patients with functioning pituitary adenomas: an observational cohort study.
To assess the clinical value of [18F]fluoroethyl-L-tyrosine PET ([18F]FET-PET) correlated with MRI in patients with functioning pituitary adenoma (FPA) with negative or equivocal conventional MRIs during diagnosis, persistent disease and recurrence. Retrospective observational cohort study of 34 patients with FPAs who underwent a total of 37 [18F]FET-PETs (Cushing’s disease: n = 19, acromegaly: n = 14, prolactinoma: n = 3, and TSH producing adenoma: n = 1) between January 2022 and April 2025. The clinical performance was assessed in the surgically treated cohort, using confirmative histopathology and/or postoperative remission as reference standard. [18F]FET-PET identified a single lesion in 28 scans (76%), two lesions in 1 scan (3%), and no lesion in 8 scans (22%). [18F]FET-PET and MRI were concordant positive in 14/37 scans, concordant negative in 1/37, discordant MRI+/[18F]FET-PET + different location in 2/37, discordant MRI-/[18F]FET-PET + in 8/37, discordant MRI+/[18F]FET-PET- in 7/37 and partly concordant in 5/37 scans. In 14 cases surgery resulted in confirmative histopathology and/or postoperative remission, 12 of those had a positive [18F]FET-PET. In 6 cases surgery did not result in confirmative histopathology and/or postoperative remission, of whom 5 had a positive [18F]FET-PET. Overall, the sensitivity was 86% and the positive predictive value 71%. In three patients with acromegaly, [18F]FET-PET was able to localize a lesion, despite biochemical control under continued somatostatin analogue treatment. [18F]FET-PET enhances lesion detection and improves personalized treatment in patients with FPA and negative or equivocal conventional MRIs throughout the disease course. Consensus on the timing of [18F]FET-PET with respect to medication and biochemical status is warranted. The online version contains supplementary material available at 10.1007/s11102-025-01634-w.
Publicações recentes
Prolactinomas treated with dopaminergic agonists: behavior in different moments of life.
Amyloidogenic pituitary prolactinoma.
📖 RevisãoEvaluation of incretin levels in patients with prolactinoma.
📖 RevisãoThe cross-talk between prolactin and growth hormone in pituitary adenomas.
🥉 Relato de casoPituitary Apoplexy With Marked Hyperprolactinemia in a 19-Year-Old Woman: A Case Report of Diagnostic Challenges and Surgical Management.
📚 EuropePMC1.212 artigos no totalmostrando 197
Prolactinoma in males: a single center experience in Northern Africa.
Medicine and pharmacy reportsThe Spectrum of Serum Prolactin Levels in Patients with Non-Functioning Sellar Masses: A Retrospective Analysis.
Neurology IndiaThe clinical value of [18F]-fluoro-ethyl-L-tyrosine PET ([18F]FET-PET) correlated with MRI in patients with functioning pituitary adenomas: an observational cohort study.
PituitarySex differences in the clinical presentation, management and long-term outcomes of pituitary tumors in children and adolescents.
PituitarySurgery for prolactinoma.
Best practice & research. Clinical endocrinology & metabolismMultiple endocrine neoplasia with an atypical clinical course and a MEN1 gene variant of uncertain pathogenicity: A case report.
Medicinep300-mediated histone H3K18 lactylation promotes mitochondrial ROS accumulation via mitophagy inhibition to potentiate dopamine agonists efficacy in prolactinomas.
Redox biologyEfficacy and long-term outcomes of dopamine agonist treatment in prolactinomas.
Best practice & research. Clinical endocrinology & metabolismDopamine agonist withdrawal in patients with prolactinoma.
Best practice & research. Clinical endocrinology & metabolismLATE DIAGNOSIS OF ACROMEGALY IN THE SETTING OF A SOMATOPROLACTINOMA.
Georgian medical newsSex-related differences in healthcare utilization and costs among patients with pituitary adenomas.
PituitaryImpact of sex on mortality in patients with pituitary adenomas.
PituitaryHypopituitarism in patients with prolactinomas: a narrative review.
Best practice & research. Clinical endocrinology & metabolismCavernous Sinus Medial Wall Resection: A Retrospective Single-Institution Study on Outcomes in Functional Pituitary Adenomas.
Operative neurosurgery (Hagerstown, Md.)Cabergoline and impulse control disorders: Screening patients with pituitary adenomas in an endocrinology clinic.
Journal of psychiatric researchDopamine Agonist Therapy Induced Fatal Pneumocephalus in Giant Prolactinoma.
JCEM case reportsA novel germline CDH23 variant as a likely cause of an ultra-giant prolactinoma.
Orphanet journal of rare diseasesThe Differences Between Dopamine Agonist-Resistant and -Non-Resistant Prolactinomas: Are There Any Predictors of a Good Response?
BiomedicinesSurgical Outcomes in Knosp Grade 3 or 4 Macroprolactinomas: What Role Does Debulking Surgery Play?
World neurosurgeryWidespread invasion of a giant prolactinoma via valveless venous channels: illustrative case.
Journal of neurosurgery. Case lessonsClass III Obesity as a Presenting Syndrome in Prolactinoma Patients: Insights Into Obesity and Metabolic Dysfunction in This Unique Group.
Clinical obesityEndoscopic Endonasal Transsphenoidal Surgery (EETS) for PitNETs: Outcomes in a Single Institution Over a Decade.
Neuro endocrinology lettersFertility and pregnancy in patients with prolactinoma.
Best practice & research. Clinical endocrinology & metabolismEndoscopic surgery for noninvasive prolactinomas: A large multicenter, single-arm, retrospective study (PRLomaSaR).
EndocrineCabergoline monotherapy in GH- and PRL-cosecreting pituitary adenomas.
Endocrine oncology (Bristol, England)Long-term cabergoline use does not predict degree of prolactinoma fibrosis nor significantly impact surgical outcomes.
PituitaryThe usefulness of cannulated prolactin test in mild hyperprolactinemia: case series and systematic review of the literature.
PituitaryGiant Prolactinoma: Challenges in Management.
AACE endocrinology and diabetesManagement for prolactinomas of postmenopausal female patients: a retrospective single-center study.
BMC endocrine disordersThe diagnostic dilemma of idiopathic granulomatous mastitis with an emphasis on histopathologic findings.
Diagnostic pathologyPituitary Apoplexy: A Case Series.
CureusRising burden of PRL-PitNETs: patterns across tumour sizes and incidentalomas.
European journal of endocrinologyAggressive Macroprolactinoma Refractory to Multiple Lines of Localized and Systemic Therapy.
JCEM case reportsCorrelation between serum endocrine hormone levels and malignancy degree of prolactinoma and their predictive value for patient prognosis.
Scientific reportsCerebrospinal fluid fistula following dopamine agonist therapy in giant prolactinomas: A case series and review of the literature.
Neurologia i neurochirurgia polskaEndoscopic endonasal surgery for prolactin-secreting adenoma: a retrospective multicenter study by the neuroendoscopy section of the Italian Society of Neurosurgery.
Journal of neurosurgeryLong-term survival in a patient with metastatic prolactinoma: a 12-year follow-up.
Proceedings (Baylor University. Medical Center)High-Risk Prostate Cancer in a Patient with Untreated Prolactinoma and Castrate-Level Testosterone Suppression: A Case Report.
Case reports in oncologyGiant Prolactinoma Resistant to High-Dose Cabergoline in a Young Male Lost to Follow-Up.
CureusCase Report: Management of a pregnancy complicated by a symptomatic macroprolactinoma.
Frontiers in medicineTherapeutic challenges of giant invasive cystic macroprolactinoma.
Endocrinology, diabetes & metabolism case reportsPituitary hormone deficiencies in prolactinomas: prevalence, predictors, and functional recovery.
Frontiers in endocrinologyEndocrine Comorbidities in Fibromyalgia.
Clinical endocrinologyAutonomic balance and cardiovascular hemodynamic function in men with prolactinoma.
Frontiers in endocrinologyApproach to the Patient With Dopamine-Resistant Microprolactinoma.
The Journal of clinical endocrinology and metabolismLoss of heterozygosity and absence of MAX immunostaining in a prolactinoma associated with multiple endocrine neoplasia type 5 (MEN5).
PituitaryAggressive prolactinomas in men are associated with visual disturbances and pituitary hormone deficiencies.
Scientific reports[Consensus on the diagnosis and treatment of pituitary prolactinoma (2025 edition)].
Zhonghua yi xue za zhi[Clinical management of pituitary prolactinoma from the perspective of obstetrics and gynecology: from reproductive health to lifespan care].
Zhonghua yi xue za zhi[Clinical practice considerations on cabergoline in the treatment of pituitary prolactinoma].
Zhonghua yi xue za zhi[Refractory pituitary prolactinoma:current treatment status and challenges].
Zhonghua yi xue za zhi[The evolving role of surgery in the management of pituitary prolactinomas].
Zhonghua yi xue za zhi[Interpretation of key updates in the "Consensus on the diagnosis and treatment of pituitary prolactinoma (2025 edition)"].
Zhonghua yi xue za zhiMultiparameter MRI-based clinical-radiomic model to differentiate prolactinoma from hyperprolactinemic nonfunctioning pituitary adenoma.
Journal of neurosurgeryManagement of a mixed ACTH- and prolactin-secreting pituitary adenoma during pregnancy.
Endocrinology, diabetes & metabolism case reportsCystic versus non-cystic prolactinoma: clinical, hormonal, radiological, and remission outcomes in Basrah.
Frontiers in endocrinologySomatostatin 5 receptor expression in prolactinomas: Is there a role for Pasireotide in the management of prolactinomas?
PituitaryDeguelin inhibits growth and prolactin synthesis in prolactinomas by targeting the PI3K/AKT/CREB3L1 pathway and ornithine decarboxylase.
Acta pharmacologica SinicaManagement outcomes of prolactinoma: a retrospective study from Southern Iraq.
Journal of medicine and lifePrevalence and Risk Factors of Dopamine Agonists Induced Impulse Control Disorders in Patients With Prolactinoma.
International journal of psychiatry in medicineImmunohistochemical Comparison of Dopamine-2 Receptor Expression in Resistant and Non-Resistant Prolactinomas.
Journal of clinical medicineStiff-person syndrome mimic secondary to hypopituitarism: a case report and literature review.
Frontiers in endocrinologyChallenges in the Management of Silent Lactotroph Pituitary Adenoma.
JCEM case reportsTranscriptomic classification of prolactinomas and somatotropinomas identifies subtypes with variable resistance to treatment.
European journal of endocrinologyMortality in patients with dopamine agonist-treated hyperprolactinemia: a large matched-cohort study.
PituitaryDynamic changes in IGF-1 levels during cabergoline therapy in prolactinoma.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research SocietySecondary Loss of Response to Dopamine Receptor Agonists in the Treatment of Macroprolactinoma.
CureusRare Occurrence of Distant Metastases in Prolactinoma: Insights From 2 Cases and Review of the Literature.
AACE endocrinology and diabetesProfile of pituitary adenoma in patients from rural areas: A study at Dr. Saiful Anwar hospital, Indonesia, 2024.
Surgical neurology internationalDebate: Surgery as Initial Therapy for Microprolactinoma.
The Journal of clinical endocrinology and metabolismHow to Define Success in Prolactinoma Treatment-A Systematic Review and Theoretical Framework.
The Journal of clinical endocrinology and metabolismAn 18-year Odyssey: navigating the complex path of prolactinoma management: a case report.
Cardiovascular diabetology. Endocrinology reportsRisk-Stratifying Pituitary Adenoma Treatment: A Cohort Analysis and Risk Prediction of Hypopituitarism.
Journal of clinical medicineProlactin secreting pituitary neuroendocrine tumors treated by dopamine agonists: predictors of response.
Frontiers in endocrinologyLong-term primary pharmacotherapy of giant prolactinomas: A comparison of different cabergoline dosages.
Journal of clinical & translational endocrinologyFollow-up of hypogonadotropic hypogonadism recovery in Chinese male prolactinoma patients treated with dopamine agonists.
EndocrineA new and useful tool for differentiating prolactinomas from non-functioning pituitary adenomas: a pilot study of the cabergoline disconnection test.
Einstein (Sao Paulo, Brazil)Paeoniflorin attenuates hyperprolactinemia by targeting the pituitary mPRα-mediated, dopamine receptor-independent signaling in vivo and in vitro.
Toxicology and applied pharmacologyProlactinomas and Knosp grade: when is surgery the appropriate choice? A systematic review and meta-analysis.
Journal of neurosurgeryThe clinicopathological PANOMEN-3 classification predicts pituitary adenoma prognosis: a real-world retrospective single center study of a surgically treated cohort.
PituitaryIdentifying Hub Genes Associated with Sex Disparities in Prolactinomas.
Genetic testing and molecular biomarkersCabergoline-induced prolactinoma treatment and subsequent estrogen-driven vascular smooth muscle tumorigenesis in a middle-aged female: A case report.
International journal of surgery case reportsUrinary incontinence as a novel and underrecognized clinical manifestation of prolactinoma in women.
PituitaryProlactin-secreting adenomas: pathogenesis, diagnosis, and management.
The lancet. Diabetes & endocrinologyLipid Profile Differences in Monomeric Hyperprolactinemia, Macroprolactinemia, and Healthy Controls: A Comparative Analysis.
NeuroendocrinologyProlactin impairs erectile function via eNOS suppression independently of testosterone.
Toxicology and applied pharmacologyEvaluating pituitary tumor management: aligning with pituitary tumor centers of excellence criteria.
PituitaryHypogonadism in men with prolactinoma: Diagnosis, treatment, and management of persistent hypogonadism.
Vitamins and hormonesWhen the fog lingers: persistent cognitive and emotional burden in patients with a prolactinoma despite disease control.
The Journal of clinical endocrinology and metabolismComprehensive Comparison of Visual Outcomes in Macro and Giant Prolactinoma Cohorts Managed With Medical Versus Surgical Treatment.
NeurosurgeryEpidemiologic Profile and Clinical Outcomes of Adult Patients with Prolactinoma at the Philippine General Hospital.
Acta medica PhilippinaThyroid Scan Conundrum in a Rare Case of McCune-Albright Syndrome.
Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, IndiaNovel germline likely pathogenic frameshift variant of the MEN1 gene contributes to multiple endocrine neoplasia type 1: a case report with review of literature.
Endocrine journalDifferential expression of PTEN, pAKT1, pRPS6, and mismatch repair proteins in pituitary neuroendocrine tumors.
Virchows Archiv : an international journal of pathologyGiant Pituitary Adenoma Presenting with Craniovertebral Junction Instability: A Case Report and Review of Literature.
Neurology IndiaSafety of Cabergoline for Prolactinoma in Pregnancy: A Systematic Review and Meta-Analysis.
Clinical endocrinologyProlactinoma Resection in a Transgender Woman on Gender-affirming Hormone Therapy.
JCEM case reportsAnemia in Patients With Pituitary Adenomas: Prevalence and Correlation With Hypopituitarism.
Cureus"Just Got Diagnosed; What Worked for You?": A Mixed-Methods Analysis of Treatment Experiences in the Prolactinoma Subreddit.
Journal of neurological surgery. Part B, Skull baseMicrobiome and metabolic disorder in prolactinoma: intrinsic gender differences and extrinsic therapy effects.
PituitaryGiant Prolactin-Secreting Pituitary Adenoma: A Case Report and Literature Review.
CureusEndoscopic endonasal transcavernous surgery for a contemporary series of 59 prolactinomas.
PituitaryHigh-dose Hook Effect in a Case of Giant Prolactinoma Confounded by Acute Kidney Injury.
JCEM case reportsEstimating diagnostic delay in patients with pituitary adenomas in Sweden: a cross-sectional study.
BMJ openBaseline testosterone levels as a predictor of hypogonadism resolution in male patients with isolated hyperprolactinemia.
PituitaryCabergoline counteracts adipose and skeletal muscle lipid accumulation: A novel therapeutic approach to obesity?
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieHyperprolactinemia caused by extra-pituitary prolactin secretion: a systematic review.
Endocrine connectionsTreatments for MEN1-associated endocrine tumours: three systematic reviews and a meta-analysis.
The lancet. Diabetes & endocrinologySubtle Cognitive Impairments and Psychological Complaints in Patients With Prolactinoma Despite Biochemical Control.
The Journal of clinical endocrinology and metabolismAdvances in Drug Treatments for Male Patients with Prolactinomas.
NeuroendocrinologyGenetic association of AIP gene variant c.910C>T with pituitary adenomaacromegaly patients of Pakistani origin.
JPMA. The Journal of the Pakistan Medical AssociationLights or shadows, a promising future for positron emission tomography in pituitary tumors: a systematic review.
Reviews in endocrine & metabolic disordersSuccessful diagnosis and monitoring of giant prolactinomas: the role of sample dilutions.
Laboratory medicineImpulse control disorders in prolactinoma patients treated with dopamine agonists: a systematic review and meta-analysis with trial sequential analysis.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of AustralasiaExamining the viability of modern endoscopic endonasal surgery as a first-line treatment for macroprolactinomas: a multicentric study on the results and significance of the highest preoperative prolactin level in predicting long-term surgical outcomes.
Journal of neurosurgeryHyperprolactinemia and cancer risk: a Swedish population-based cohort study.
Endocrine connectionsImpulse control disorders in pituitary adenoma: What do we know and what we still don't know in almost two decades?
PituitaryWogonin inhibits the proliferation of prolactinoma through the PI3K/AKT signaling pathway.
Frontiers in pharmacologyAtherosclerosis enhances the efficacy of liposome-encapsulated bromocriptine in reducing the incidence of prolactinemia in pituitary tumors.
Journal of nanobiotechnologyHyperprolactinemia in children and adolescents: clinical characteristics and etiological spectrum.
European journal of pediatricsThe effect of hyperprolactinemia and its treatment on oxidative stress.
Endocrine researchImpact of Tumor Size on Prolactinoma Characteristics and Treatment Outcomes: A Study of a Tunisian Cohort.
BiomedicinesCabergoline monotherapy in polycystic ovary syndrome patients with elevated prolactin: a viable option?
EndocrineSpatial transcriptomics reveal PI3K-AKT and metabolic alterations in aggressive, treatment-resistant lactotroph pituitary neuroendocrine tumors.
Acta neuropathologica communicationsElevated Dehydroepiandrosterone Sulfate Levels in 2 Patients With Prolactinomas: An Underrecognized Association.
JCEM case reportsMicroRNA Is Downregulated in Invasive Non-Functioning Pituitary Adenomas.
International journal of molecular sciencesSoluble alpha klotho-impact of biological variables and reference intervals for adults.
European journal of endocrinologyCabergoline-induced cerebrospinal fluid fistulae in macroprolactinomas.
Langenbeck's archives of surgeryPediatric Pituitary Adenomas and Cysts: A 46-Year Population-Based Analysis.
Journal of the Endocrine SocietyImpulse Control Disorders in Patients With Hyperprolactinemia on Dopamine Agonist Therapy-How Concerned Should We Be?
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical EndocrinologistsCholesterol-activated stress granules reduce the membrane localization of DRD2 and promote prolactinoma dopamine agonists resistance.
Acta neuropathologica communicationsNavigating prognostic strategies for GH- and PRL-secreting pituitary neuroendocrine tumors: key insights from a clinicopathological study.
Frontiers in endocrinologyIntracavitary Yttrium-90 Colloid Therapy for Cystic Sellar Masses: A Phase II Clinical Trial With 5-Year Follow-Up.
NeurosurgeryFunctional Suppression of a Prolactinoma by a Dopamine-Secreting Paraganglioma.
JCEM case reportsImpulse control disorders in patients with pituitary adenoma managed with or without dopamine agonists: a cross-sectional study from a UK centre.
PituitaryThe contribution of prolactin in the occurrence of premature cardiovascular disease predominantly through modulating the inflammatory cascade.
European journal of clinical investigationPulmonary Fibrosis in a Patient With a Prolactinoma on Dopamine Agonists: Coincidence or Consequence.
JCEM case reportsDouble pituitary adenoma associated with acromegaly and hyperprolactinemia: a case report.
Archives of endocrinology and metabolismTranscriptomic analysis of the anti-tumor effects of leflunomide in prolactinoma.
Scientific reportsCirculating miR-20a-5p as a biomarker associated with cabergoline responsiveness in patients with hyperprolactinemia and pituitary adenomas.
European journal of endocrinologyResistant PRL-secreting PitNET associated with breast carcinoma: a case report and literature review.
International cancer conference journalMultiple endocrine neoplasia type 1 in childhood and description of a novel variant.
Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao PauloCabergoline Use and Pregnancy Outcomes: A Systematic Review.
Birth defects researchGender differences in prolactin thresholds and their association with lactotroph adenoma invasiveness for potential treatment considerations.
Scientific reportsEctopic dopamine agonist-resistant macroprolactinoma to the clivus masquerading as a chordoma - A case report.
Endocrine regulationsReassessing the role of the p.(Arg304Gln) missense AIP variant in pituitary tumorigenesis.
European journal of endocrinologyGood response rates and predictors during the first year of cabergoline treatment in large invasive prolactinomas.
PituitaryMenopause Has a Beneficial Influence on the Evolution of Prolactinomas. A Study of 99 Patients.
The Journal of clinical endocrinology and metabolismDopamine agonists and weight changes in prolactinoma patients.
PituitaryRecovery of hypopituitarism in macroprolactinomas: a comparison of medical vs. surgical treatment. Results from a European multicenter study.
Journal of endocrinological investigationA Narrative Review of Surgery for Prolactinomas: Considerations and Controversies.
Journal of clinical medicineDouble PitNETs: A Case Report and Literature Review.
CancersmiR-21-5p Targets PIK3R1 to Regulate the NF-κB Signaling Pathway, Inhibiting the Invasion and Progression of Prolactinoma.
International journal of endocrinologyArrested Puberty in a Young Adult With a Macroprolactinoma: Case Report and Literature Review.
Case reports in endocrinologyMultiple Endocrine Neoplasia Type 1 With Adrenal Cortical Adrenocortical Carcinoma: A 25-Year Follow-Up and Family Report.
JCEM case reportsOvarian cancer causing hyperprolactinemia: A case report and narrative review.
MedicineIschemic stroke risk in patients with dopamine agonist-treated hyperprolactinemia.
Journal of neuroendocrinologyHeadache in pituitary adenomas: frequency, characteristics and outcome after treatment.
PituitaryProlactin-secreting pituitary carcinomas with intra- and extracranial metastasis: case report and review.
Zhurnal voprosy neirokhirurgii imeni N. N. BurdenkoAripiprazole use as a cause of dopamine agonist failure in the treatment of prolactinomas.
Endocrine oncology (Bristol, England)Predictors of favorable long-term outcomes in first-line surgery for microprolactinomas.
Journal of neuro-oncologyOutcomes in surgical management of microprolactinomas: an international multi-institutional series.
PituitaryExploring sex-specific hematological changes and their impact on quality of life in patients with prolactinoma.
PituitaryHypogonadism in a Man With Cystic Fibrosis and an Unusually Low Serum Testosterone: A Cautionary Tale.
AACE clinical case reportsEtiology, presentation, and outcomes of hyperprolactinemia due to pituitary masses in children and adolescents.
EndocrineCabergoline-induced NDFIP1 upregulation in pituitary neuroendocrine tumor cells activates mTOR signaling and contributes to cabergoline resistance.
Journal of neuro-oncologyConservative medical therapy for a macroprolactinoma presenting with obstructive hydrocephalus.
BMJ case reportsPsychological burden in patients with sellar masses under conservative and surgical management.
Neurosurgical reviewA rare case of double pituitary prolactinomas: the diagnostic application of intraoperative ultrasonography and DNA methylation markers.
Archives of endocrinology and metabolismCabergoline Induced Pathological Gambling in an Adolescent with Prolactinoma.
Journal of clinical research in pediatric endocrinologyDeterminants of cerebrospinal fluid leakage in a large cohort of macroprolactinomas.
Annales d'endocrinologieGonadotropic axis following endoscopic surgery for pituitary neuroendocrine tumor in patients of reproductive age.
Annales d'endocrinologieHyperprolactinemia complicated with peliosis hepatis: One case report and review of literature.
MedicineCorrelation between MRI findings of pituitary gland and prolactin level among hyperprolactinemia adult female Saudi patients in rural areas: A retrospective multicentric study.
MedicineScreening with Metoclopramide Test to Reduce Unnecessary Pituitary Magnetic Resonance Studies in Moderate Hyperprolactinemia.
The journal of applied laboratory medicineRET signalling in the pituitary: a double-edged sword for differentiation, apoptosis and therapeutic strategies in acromegaly.
Endocrine-related cancerGenotype-negative multiple endocrine neoplasia type 1 with prolactinoma, hyperparathyroidism, and subclinical Cushing's syndrome accompanied by hyperglycemia: a case report.
Frontiers in endocrinologyPharmacological management of pituitary adenomas - what is new on the horizon?
Expert opinion on pharmacotherapyPolycystic Ovary Syndrome in the Context of Pituitary Adenomas: Prevalence, Pathophysiology and Clinical Management.
Clinical endocrinologyGiant prolactinoma with progressive cranial settling and central herniation: a case report.
Journal of medical case reportsPituitary adenomas in children: surgical course and functional outcome. Lille cohort retrospective study.
Neuro-ChirurgieIncidence of postoperative cerebrospinal fluid leaks in endoscopic endonasal transsphenoidal surgery for pituitary adenomas without sellar floor reconstruction: A retrospective observational study from a low-middle-income country.
Pakistan journal of medical sciencesMicroRNA networks in prolactinoma tumorigenesis: a scoping review.
Cancer cell internationalMultiple Eyelid Apocrine Hidrocystomas in a Patient With Prolactinoma.
Ophthalmic plastic and reconstructive surgeryThe Activation of p300 Enhances the Sensitivity of Pituitary Adenomas to Dopamine Agonist Treatment by Regulating the Transcription of DRD2.
International journal of molecular sciencesZuyangping formula promotes skin wound healing in diabetic rats.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen panAssessment of the initial results of pituitary tumor registry at a tertiary hospital of Iran: 2009-2022.
Journal of diabetes and metabolic disordersDisease Activity and Maternal-fetal Outcomes in Pregnant Women With Prolactinoma: A Systematic Review and Meta-analysis.
The Journal of clinical endocrinology and metabolismSpontaneous Cerebrospinal Fluid Rhinorrhea in Pre-operative Pituitary Adenoma: A Report of Two Cases.
CureusDiagnostic Utility of the Prolactin Decrease Rate in the Diagnosis of Mild Hyperprolactinemia.
CureusClinical Features and Hormonal Profile of Macroprolactinomas Presenting With the Hook Effect: A Systematic Review.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical EndocrinologistsModern approach to bone comorbidity in prolactinoma.
Pituitary[Efficacy of standard methods in the treatment of prolactin-secreting pituitary carcinoma].
Problemy endokrinologiiMass Spectrometric and Immunologic Detection of Prolactin-Derived Vasoinhibin in Human Serum.
Clinical laboratoryReframing the Paradigm: A Nuanced Approach to Prolactinoma Management.
Endocrinology and metabolism (Seoul, Korea)Clinical parameters and postoperative outcomes of pituitary adenomas in children: Analysis according to size of adenomas and adopted surgical procedures.
Molecular and clinical oncologyB2R-D2R Interaction in Prolactinomas and Nonfunctional Adenomas: Impact on Dopamine Resistance.
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- The Spectrum of Serum Prolactin Levels in Patients with Non-Functioning Sellar Masses: A Retrospective Analysis.
- A novel germline CDH23 variant as a likely cause of an ultra-giant prolactinoma.
- Prolactinoma in males: a single center experience in Northern Africa.
- Familial prolactinomas.Best practice & research. Clinical endocrinology & metabolism· 2026· PMID 41850963mais citado
- The clinical value of [18F]-fluoro-ethyl-L-tyrosine PET ([18F]FET-PET) correlated with MRI in patients with functioning pituitary adenomas: an observational cohort study.
- Prolactinomas treated with dopaminergic agonists: behavior in different moments of life.
- Amyloidogenic pituitary prolactinoma.
- Evaluation of incretin levels in patients with prolactinoma.
- The cross-talk between prolactin and growth hormone in pituitary adenomas.
- Pituitary Apoplexy With Marked Hyperprolactinemia in a 19-Year-Old Woman: A Case Report of Diagnostic Challenges and Surgical Management.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:2965(Orphanet)
- OMIM OMIM:600634(OMIM)
- MONDO:0010911(MONDO)
- GARD:4508(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
- Q954831(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
