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Subependimoma
ORPHA:251639CID-10 · D43.2CID-11 · 2A00.0YDOENÇA RARA

Subependimoma é um tipo raro de ependimoma, que cresce devagar. Costuma surgir em adultos de meia-idade e é mais comum em homens do que em mulheres. Geralmente, ele se localiza nos ventrículos cerebrais (o quarto e os laterais) e pode causar sintomas variados, como dor de cabeça, náuseas e perda de equilíbrio. Em alguns casos, a pessoa não apresenta sintoma algum. Normalmente, este tipo de tumor tem um prognóstico melhor do que outras formas de ependimoma.

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Introdução

O que você precisa saber de cara

📋

Subependimoma é um tipo raro de ependimoma, que cresce devagar. Costuma surgir em adultos de meia-idade e é mais comum em homens do que em mulheres. Geralmente, ele se localiza nos ventrículos cerebrais (o quarto e os laterais) e pode causar sintomas variados, como dor de cabeça, náuseas e perda de equilíbrio. Em alguns casos, a pessoa não apresenta sintoma algum. Normalmente, este tipo de tumor tem um prognóstico melhor do que outras formas de ependimoma.

Publicações científicas
396 artigos
Último publicado: 2026 Feb

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
<1 / 1 000 000
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Europe
Início
Adult
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: D43.2
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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🫃
Digestivo
2 sintomas
🫁
Pulmão
1 sintomas
🧠
Neurológico
1 sintomas
💪
Músculos
1 sintomas

+ 10 sintomas em outras categorias

Características mais comuns

100%prev.
Ependimoma
55%prev.
Dor
Frequente (79-30%)
55%prev.
Morfologia celular anormal
Frequente (79-30%)
55%prev.
Enxaqueca
Frequente (79-30%)
17%prev.
Vômitos
Ocasional (29-5%)
17%prev.
Disestesia
Ocasional (29-5%)
15sintomas
Muito frequente (1)
Frequente (3)
Ocasional (7)
Muito raro (4)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 15 características clínicas mais associadas, ordenadas por frequência.

EpendimomaEpendymoma
Muito frequente100%
DorPain
Frequente (79-30%)55%
Morfologia celular anormalAbnormal cell morphology
Frequente (79-30%)55%
EnxaquecaMigraine
Frequente (79-30%)55%
VômitosVomiting
Ocasional (29-5%)17%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico396PubMed
Últimos 10 anos157publicações
Pico202328 papers
Linha do tempo
2026Hoje · 2026🧪 1993Primeiro ensaio clínico📈 2023Ano de pico
Publicações por ano (últimos 10 anos)

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Genética e causas

O que está alterado no DNA e como passa nas famílias

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Nenhum gene associado encontrado

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Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
1Fase 14
·Pré-clínico2
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 6 ensaios
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Ensaios clínicos abertos e novidades científicas recentes

Pesquisa e ensaios clínicos

45 ensaios clínicos encontrados.

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Publicações mais relevantes

🥉Melhor nível de evidência: Relato de caso
Timeline de publicações
157 papers (10 anos)
#1

Incidental Subependymoma of the Floor of the Fourth Ventricle: A Case Report.

Cureus2026 Feb

Subependymomas are rare, slow-growing intraventricular tumors that are typically discovered incidentally and seldom present with transient sensory symptoms in young adults. We report the case of a 22-year-old woman who presented with episodic migratory paresthesias and was found on brain MRI to have a small fourth-ventricular lesion radiographically consistent with subependymoma. The patient's sensory symptoms resolved spontaneously, and no further episodes occurred. Conservative management with serial imaging was pursued. At the six-month follow-up, the lesion remained stable, and the patient was asymptomatic. Subependymomas most commonly become symptomatic due to cerebrospinal fluid obstruction, whereas episodic migratory paresthesias are unusual. This case highlights the value of early MRI in young adults with atypical sensory symptoms, which may reveal incidental yet clinically significant findings and help avoid unnecessary invasive testing. Small, non-obstructive fourth-ventricle subependymomas can be safely managed with observation, demonstrating excellent short-term clinical and radiographic outcomes.

#2

Two pediatric supratentorial ependymal tumors with novel PLAG1 fusions.

Acta neuropathologica communications2026 Feb 04

The 2021 World Health Organization (WHO) Classification of Central Nervous System (CNS) classification formalized routine molecular profiling, and DNA-methylation studies have since delineated PLAG-family-altered CNS entities: PLAGL1 fusion-positive supratentorial neuroepithelial tumors (NET_PLAGL1) and embryonal tumors with PLAGL1/PLAGL2 amplification. PLAG1 fusions with diverse partners have been reported in CNS embryonal tumors, but have not been described in supratentorial neuroepithelial tumors to date. We describe two pediatric supratentorial ependymal tumors with novel PLAG1 fusions that do not match any 2021 WHO-defined entity or any PLAG-family-related entity recently reported in the literature. Case 1 (4-year-old boy) had a 7.6-cm left lateral ventricular mass with edema and heterogeneous enhancement; gross total resection was performed without adjuvant therapy (alive at 8 months). Histology showed diffusely low cellularity with small- to medium-sized round nuclei, minimal atypia, and focal calcifications; no ependymal rosettes, branching vessels, or clear-cell change. Tumor cells were positive for GFAP and H3K27me3, and negative for Desmin, EMA, OLIG2, L1CAM, NF-κB and H3K27M. The MIB-1 labeling index was ~ 5%. RNA-seq identified TNC::PLAG1 fusion; FISH showed PLAG1 rearrangement. DNA methylation clustered with spinal subependymoma, despite supratentorial location. Case 2 (4-year-old girl) had a 1.4 × 1.1 cm left parahippocampal lesion; resected without adjuvant therapy (alive at 4 months). Histology showed low-to-moderate cellularity with diffuse microcystic change, focal clear/vacuolated cells, and delicate branching vessels. Tumor cells were positive for GFAP, EMA, L1CAM, H3K27me3 and ATRX, and negative for EMA, Desmin, NF-κB, OLIG2, H3K27M, and CD34 (MIB-1 ~ 2%). RNA-seq identified TXNIP::PLAG1 fusion. Methylation did not reach a class threshold. Both cases ultimately warrant a final diagnosis of ependymal tumor, not elsewhere classified. To our knowledge, TNC::PLAG1 and TXNIP::PLAG1 are first-ever fusions reported in any tumor type. They also represent the first PLAG1 fusions identified in pediatric supratentorial ependymal tumors. These cases highlight the value of integrating histology, methylation profiling, and fusion detection, and suggest a new candidate supratentorial ependymal subtype with PLAG1 fusions, pending validation in larger series.

#3

Ependymal Tumors.

Neuroimaging clinics of North America2026 Feb

The 2021 WHO Brain Tumor classification update grouped ependymal tumors into 3 anatomic locations-supratentorial, posterior fossa, and spinal. Supratentorial ependymomas now include ZFTA-fusion tumors which are often cystic, hemorrhagic, and show marked edema and YAP1-fusion tumors which demonstrate garlanded peripheral solid enhancement and diffusion-restriction. Posterior fossa ependymomas are now grouped by methylation profile into category A-typical posterior fossa ependymoma and category B which present in older children with smaller lesions with a better prognosis. Spinal ependymoma is relatively unchanged by molecular characterization apart from the new MYCN-altered tumor which has poor prognosis and is often advanced/disseminated at presentation.

#4

Resection of a Cerebellopontine Angle Ependymoma Using a Far Lateral Approach: 2-Dimensional Operative Video.

Operative neurosurgery (Hagerstown, Md.)2026 Feb 01
#5

Aggressive biological behavior of benign central nervous system neoplasms: The case of hemorrhagic subependymomas - An illustrated review.

Surgical neurology international2025

Subependymomas (SEs) are low-frequency, histologically benign tumors. Their association with hemorrhagic phenomena is extremely unusual. This is a literature review of pathologically verified reports of hemorrhagic SE (hSE), analyzing their epidemiological, clinical, diagnostic, therapeutic, and outcome features. This review includes an original illustrating report. A total of 30 cases were analyzed. All but three patients presented unique hSEs growing predominantly within the lateral ventricles (86.6%). The pattern of associated hemorrhage was, in decreasing order of frequency, intratumoral (55.2%), mixed, and extratumoral. Symptoms at presentation, mainly of rapid onset (75%), derived from high intracranial pressure, meningeal irritation, and/or focal neurological impairment. Superficial siderosis was an exceptional complication, presumably produced after repeated bleeding. Most hSEs were misdiagnosed either as a more aggressive neoplasm (84.6%) or as a vascular malformation (7.7%) because of their invariably atypical, heterogeneous radiological appearance. Twenty-nine patients underwent surgical treatment, reaching total resection rates close to 80%. Nevertheless, high figures of both permanent disability (25%) and mortality (10.3%) were recorded at the last follow-up. Bleeding increases both the severity of initial clinical symptoms and the complexity of the radiological differential diagnosis of SEs but does not seem to influence strongly the degree of surgical resection of these otherwise histologically benign neoplasms. Both the exact topography of the hSE within the ventricular system and the presence of intraparenchymal extension of the neoplasm and/or the associated bleeding could negatively affect the final clinical outcome.

Publicações recentes

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📚 EuropePMC214 artigos no totalmostrando 152

2026

Incidental Subependymoma of the Floor of the Fourth Ventricle: A Case Report.

Cureus
2026

Two pediatric supratentorial ependymal tumors with novel PLAG1 fusions.

Acta neuropathologica communications
2025

Aggressive biological behavior of benign central nervous system neoplasms: The case of hemorrhagic subependymomas - An illustrated review.

Surgical neurology international
2025

Brainstem tumors with subependymoma-like morphology and H3K27M mutation are epigenetically distinct.

Journal of neuropathology and experimental neurology
2025

Multi-omics analysis delineates molecular signatures of spinal ependymal tumor.

Cellular oncology (Dordrecht, Netherlands)
2025

The Role of D-Wave Monitoring in Motor-Evoked Potential Loss During Intramedullary Spinal Cord Tumors Resection.

Neurospine
2025

A Rare Case of Bilateral Lateral Ventricular Subependymomas With Complete Resection of the Residual Tumor via Flexible Neuroendoscopy 20 Years After Initial Surgery.

Cureus
2025

Nationwide Brain Tumor Registry-based Study of Adult Intracranial Ependymoma in Japan.

Neurologia medico-chirurgica
2025

Microsurgical removal of a C1-C5 laterally located intramedullary subependymoma through a postero-lateral sulcus approach: case report, surgical video and critical review of diagnostic and surgical challenges.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
2025

Long-term follow-up after stereotactic radiosurgery for recurrent subependymoma.

Journal of radiosurgery and SBRT
2026

Resection of a Cerebellopontine Angle Ependymoma Using a Far Lateral Approach: 2-Dimensional Operative Video.

Operative neurosurgery (Hagerstown, Md.)
2025

Clinical characteristics and prognostic factors of primary spinal subependymoma: a single-center cohort study and systematic review.

Journal of neuro-oncology
2025

Characteristics and therapeutic profile of the patients with upper cervical spinal cord ependymoma from the medulla oblongata to C4: A cohort of 108 cases.

Clinical neurology and neurosurgery
2025

Low-grade gliomas presenting with hemorrhage: Are intratumoral blood products associated with malignant transformation?

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
2024

Supratentorial and Infratentorial Ependymoma.

Advances and technical standards in neurosurgery
2024

Concurrent ependymal and ganglionic differentiation in a subset of supratentorial neuroepithelial tumors with EWSR1-PLAGL1 rearrangement.

Acta neuropathologica communications
2025

Distinct relapse pattern across molecular ependymoma types.

Neuro-oncology
2024

Ependymal Tumors: Overview of the Recent World Health Organization Histopathologic and Genetic Updates with an Imaging Characteristic.

AJNR. American journal of neuroradiology
2024

Spinal Intradural Tumor Resection via Long-Segment Approaches and Clinical Long-Term Follow-Up.

Cancers
2024

CNS tumors with PLAGL1-fusion: beyond ZFTA and YAP1 in the genetic spectrum of supratentorial ependymomas.

Acta neuropathologica communications
2024

Ependymomas of the spinal region in adults: Clinical and pathological features and MYCN expression levels in spinal ependymomas and myxopapillary ependymomas.

Annals of diagnostic pathology
2024

Sentinel report of uniquely paired collision tumors: glioblastoma multiforme and coexistent intraventricular subependymoma. Illustrative case.

Journal of neurosurgery. Case lessons
2024

Intraventricular Subependymoma With Obstructive Hydrocephalus: A Case Report and Literature Review.

Cureus
2024

Intraoperative discovery of a radiographically occult subependymoma obstructing the obex in a patient with a Chiari malformation - A rare case.

Surgical neurology international
2023

Disappearance of a Ruptured Feeding Artery Fusiform Aneurysm After the Resection of a Large Subependymoma: A Case Report.

Cureus
2023

Spinal ependymoma in adults: from molecular advances to new treatment perspectives.

Frontiers in oncology
2023

Capgras Syndrome After Bifrontal Craniotomy for Excision of Right Lateral Intraventricular Subependymoma.

The primary care companion for CNS disorders
2023

Subependymomas of the fourth ventricle: To operate or not to operate?

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
2023

Surgical resection of recurrent intramedullary subependymoma of the cervical spinal cord.

Neurosurgical focus: Video
2023

Resection of intradural intramedullary subependymoma of the cervicothoracic spine: 2-dimensional operative video.

Neurosurgical focus: Video
2023

Intramedullary Subependymoma Of Lower Thoracic Cord.

JPMA. The Journal of the Pakistan Medical Association
2023

[Ependymoma in WHO Classification of Tumours 5th Edition].

No shinkei geka. Neurological surgery
2023

Lateral ventricle subependymoma resected with a transcallosal approach: illustrative case.

Journal of neurosurgery. Case lessons
2023

Bruns syndrome in a patient with intraventricular subependymoma: a case report.

Postepy psychiatrii neurologii
2024

Immunohistochemical analyses of neural stem cell lineage markers in normal feline brains and glial tumors.

Veterinary pathology
2023

Spinal Cord Subependymoma: A Subanalysis of the Neurospinal Society of Japan's Multicenter Study of Intramedullary Spinal Cord Tumors.

Neurospine
2023

Classification and neuroimaging of ependymal tumors.

Frontiers in pediatrics
2023

Predictors of Progression-Free Survival in Patients With Spinal Intramedullary Ependymoma: A Multicenter Retrospective Study by the Neurospinal Society of Japan.

Neurosurgery
2023

Epigenetic Alteration of H3K27me3 as a Possible Oncogenic Mechanism of Central Neurocytoma.

Laboratory investigation; a journal of technical methods and pathology
2023

The Ribbon Sign as a Radiological Indicator of Intramedullary Spinal Cord Subependymomas.

World neurosurgery
2023

Coexistence of Two Distinct Tumor Types Within One Posterior Fossa Mass Lesion in an Adult Patient Verified by DNA-Methylation Analysis: A Case Report.

Cureus
2023

Third Ventricular Subependymomas: Clinical Features and Outcomes Over Two Decades.

World neurosurgery
2023

Shunt dependency in supratentorial intraventricular tumors depends on the extent of tumor resection.

Acta neurochirurgica
2023

Clinical Characteristics, Management, and Outcomes of Intramedullary Spinal Cord Ependymomas in Adults: A Systematic Review.

World neurosurgery
2023

Adult intracranial ependymoma-relevance of DNA methylation profiling for diagnosis, prognosis, and treatment.

Neuro-oncology
2023

Balloon-Assisted Corpus Callosotomy. Reducing the Impact of Transcallosal Approaches.

Operative neurosurgery (Hagerstown, Md.)
2023

Microsurgical Resection of Fourth Ventricle Subependymoma: 3-Dimensional Operative Video.

Operative neurosurgery (Hagerstown, Md.)
2023

Possible association of trichorhinophalangeal syndrome I and intracranial subependymoma.

Clinical genetics
2022

Lateral Horizontal Head Position Approach for the Lateral and Anterior Third Ventricles: A Subependymoma Clinical Case and Literature Review.

Asian journal of neurosurgery
2023

A cystic anaplastic ependymoma mimicking a pilocytic astrocytoma.

Radiology case reports
2023

Intracranial germinoma in the lateral ventricle with polydipsia and polyuria: a case report and literature review.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2022

Pathological Classification of the Intramedullary Spinal Cord Tumors According to 2021 World Health Organization Classification of Central Nervous System Tumors, a Single-Institute Experience.

Neurospine
2023

Survival of patients and risk factors for subependymoma: a population-based study.

Neurological research
2022

Clinical independent prognostic factors and overall survival prognostic nomogram for intracranial subependymoma: A SEER population-based analysis 2004-2016.

Frontiers in oncology
2022

A Case of Lateral Ventricular Subependymoma with Intratumoral Hemorrhage via Neuroendoscopic Surgery.

NMC case report journal
2022

5-Aminolevulinic acid fluorescence-guided endoscopic surgery for intraventricular tumors.

Surgical neurology international
2022

Resection of brain lesions with a neuroendoscopic ultrasonic aspirator - a systematic literature review.

Neurosurgical review
2022

Diagnosis of symmetric bilateral lateral ventricular subependymomas: A case report.

Experimental and therapeutic medicine
2022

Subdural Direct Wave Intraoperative Neurophysiological Monitoring in Intramedullary Spinal Cord Tumor Resection: Case Report.

The Neurodiagnostic journal
2022

Coexistence of meningioma and other intracranial benign tumors in non-neurofibromatosis type 2 patients: A case report and review of literature.

World journal of clinical cases
2023

A Case of Cerebellar Intraparenchymal Subependymoma with Next-Generation Sequencing Analysis.

International journal of surgical pathology
2022

Imaging characteristics of 4th ventricle subependymoma.

Neuroradiology
2021

Superficial siderosis and nonobstructive hydrocephalus due to subependymoma in the ventricle: An illustrative case report.

Surgical neurology international
2022

Non-enhancing intraventricular tumours in adults.

JPMA. The Journal of the Pakistan Medical Association
2022

Clinical features and surgical outcomes of intracranial and spinal cord subependymomas.

Journal of neurosurgery
2022

Commentary: Step-by-Step Guide on How to Make a 2-Dimensional Operative Neurosurgical Video: Microsurgical Resection of Right Lateral Ventricle Subependymoma by an Anterior Interhemispheric Transcallosal Approach.

Operative neurosurgery (Hagerstown, Md.)
2022

Step-by-Step Guide on How to Make a 2-Dimensional Operative Neurosurgical Video: Microsurgical Resection of a Right Lateral Ventricle Subependymoma by an Anterior Interhemispheric Transcallosal Approach.

Operative neurosurgery (Hagerstown, Md.)
2021

Molecular Classification and Therapeutic Targets in Ependymoma.

Cancers
2021

Large Subependymoma Inferior to the Cerebellopontine Angle With Significant Obstructive Hydrocephalus: A Case Report on an Extremely Rare Tumor.

Cureus
2022

Tumor characteristics and surgical outcomes of intracranial subependymomas: a systematic review and meta-analysis.

Journal of neurosurgery
2022

PAX6 is frequently expressed in ependymal tumours and associated with prognostic relevant subgroups.

Journal of clinical pathology
2021

A case of chronic dysaesthesia in the torso and upper limbs: lessons from a cervical spinal cord subependymoma.

Spinal cord series and cases
2021

Intraparenchymal subependymoma: Case report and literature review.

Surgical neurology international
2021

Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion-Positive Supratentorial Ependymomas.

Cancer discovery
2021

TERT promoter mutation and chromosome 6 loss define a high-risk subtype of ependymoma evolving from posterior fossa subependymoma.

Acta neuropathologica
2021

Intraoperative contrast-enhanced ultrasound for intramedullary spinal neoplasms: patient series.

Journal of neurosurgery. Case lessons
2021

Iatrogenic Hypothalamus Injury After Resection of Subependymoma Within the Left Brain Ventricle.

Cureus
2020

Navigated Endoport in the Purely Endoscopic Microsurgery of Intraventricular and Other Deep-Seated Brain Lesions: A Case Report.

Acta medica academica
2020

Intraventricular neuroepithelial tumors: surgical outcome, technical considerations and review of literature.

BMC cancer
2021

Spinal cord subependymoma mimicking syringomyelia in a child: a case report.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2022

How I do it: minimally invasive resection of a sub-ependymoma of the fourth ventricle.

Acta neurochirurgica
2020

Different radioinducid tumors synchrony in an acute lymphoblastic leukemia survivor.

Neurocirugia
2021

Acute Hydrocephalus from Translocated Subependymoma.

Clinical neuroradiology
2020

An atypical presentation of primary central nervous system lymphoma: A case report.

Medicine
2021

A rare case of intraparenchymal subependymoma in a child.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2020

FROM ERECTILE DYSFUNCTION TO BRAIN SUBEPENDYMOMA: A CASE REPORT.

Acta clinica Croatica
2020

Intramedullary Masses of the Spinal Cord: Radiologic-Pathologic Correlation.

Radiographics : a review publication of the Radiological Society of North America, Inc
2020

cIMPACT-NOW update 7: advancing the molecular classification of ependymal tumors.

Brain pathology (Zurich, Switzerland)
2020

A Rare Case of Postinfectious Moyamoya Syndrome: Case Report and Review of the Literature.

World neurosurgery
2020

Short-term outcome following surgery for rare brain tumor entities in adults: a Swedish nation-wide registry-based study and comparison with SEER database.

Journal of neuro-oncology
2020

Collision Glial Neoplasms Arising in an Ovarian Mature Cystic Teratoma: A Rare Event.

Case reports in pathology
2020

Subependymoma of the Conus Medullaris with Cystic Formation: Case Report and a Literature Review.

World neurosurgery
2019

Infiltrative subependymoma of the brainstem: an uncommon presentation.

Radiologia brasileira
2020

Is This Truly A "Leave-Me-Alone" Lesion? An Unusual Case of Multiple Ring-shaped Lateral Ventricular Nodules.

World neurosurgery
2020

Microsurgical Resection of the IV Ventricle Subependymoma: 2-Dimensional Operative Video.

Operative neurosurgery (Hagerstown, Md.)
2019

A First Case Report of Subependymoma in PTPN11 Mutation-Associated Noonan Syndrome.

Case reports in neurological medicine
2019

Telovelar approach for microsurgical resection of fourth ventricular subependymoma arising from rhomboid fossa: operative video and technical nuances.

Neurosurgical focus: Video
2019

Minimizing cortical disturbance to access ventricular subependymoma - A novel approach utilizing spinal minimally invasive tubular retractor system.

Surgical neurology international
2020

Spinal subependymoma surgery: do no harm. Little may be more!

Neurosurgical review
2019

Unusual Exophytic Appearance of Spinal Cord Subependymoma.

World neurosurgery
2019

Subpial Cervical Subependymoma: Report of an Unusual Tumor with Review of Literature.

Asian journal of neurosurgery
2019

Subependymoma and dysembryoplastic neuroepithelial collision tumor in the foramen of Monro: case report.

Journal of neurosurgery. Pediatrics
2019

Subependymoma involving multiple spinal cord levels: A clinicopathological case series with chromosomal microarray analysis.

Neuropathology : official journal of the Japanese Society of Neuropathology
2019

Pneumatosis Intestinalis After Molecular-Targeted Therapy.

World neurosurgery
2018

Unedited microneurosurgery of a pineal region ependymoma.

Surgical neurology international
2019

High frequency of H3 K27M mutations in adult midline gliomas.

Journal of cancer research and clinical oncology
2018

[Intramedullary spinal cord tumour as differential diagnosis to bilateral muscle weakness].

Ugeskrift for laeger
2019

Detection of H3K27M mutation in cases of brain stem subependymoma.

Human pathology
2019

Flexible Fiber CO2 Laser in Microsurgical Treatment of Intraventricular Tumors: Usefulness and Limitations.

World neurosurgery
2019

Diagnostics of pediatric supratentorial RELA ependymomas: integration of information from histopathology, genetics, DNA methylation and imaging.

Brain pathology (Zurich, Switzerland)
2022

Cervical Spinal Ependymoma With Hemorrhage in a Renal Transplant Patient.

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation
2018

MRI of intracranial intraventricular lesions.

Clinical imaging
2019

A symptomatic large subependymoma with neuroradiological features mimicking a high-grade glioma: A case report.

Neurocirugia
2018

DNA methylation-based classification of ependymomas in adulthood: implications for diagnosis and treatment.

Neuro-oncology
2018

Heterogeneity within the PF-EPN-B ependymoma subgroup.

Acta neuropathologica
2018

Surgical management and long-term outcome of intracranial subependymoma.

Acta neurochirurgica
2018

Subependymomas - Characteristics of a "Leave me Alone" Lesion.

RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin
2018

Corrigendum to "Intratumoral Hemorrhage as an Unusual Manifestation of Intracranial Subependymoma" [World Neurosurg. (2018) 114:e647-e653].

World neurosurgery
2019

A Case of Rapidly-Progressing Cervical Spine Subependymoma with Atypical Features.

Spine surgery and related research
2018

Surgical outcomes of spinal cord and cauda equina ependymoma: Postoperative motor status and recurrence for each WHO grade in a multicenter study.

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
2018

Intratumoral Hemorrhage as an Unusual Manifestation of Intracranial Subependymoma.

World neurosurgery
2018

Spinal Cord Subependymoma Surgery : A Multi-Institutional Experience.

Journal of Korean Neurosurgical Society
2018

Recognizing intraventricular silicone.

Emergency radiology
2018

Squash cytology findings of subependymomas: A report of three cases and differential diagnosis.

Diagnostic cytopathology
2019

Apoplexy of a collision tumour composed of subependymoma and cavernous-like malformation in the lateral ventricle: a case report.

British journal of neurosurgery
2017

Deceptive morphologic and epigenetic heterogeneity in diffuse intrinsic pontine glioma.

Oncotarget
2017

Subependymomas Are Low-Grade Heterogeneous Glial Neoplasms Defined by Subventricular Zone Lineage Markers.

World neurosurgery
2017

Recent Advances in the Classification and Treatment of Ependymomas.

Current treatment options in oncology
2017

You're the Flight Surgeon.

Aerospace medicine and human performance
2018

Bilateral lateral ventricular subependymoma with extensive multiplicity presenting with hemorrhage.

The neuroradiology journal
2017

Characterization of gliomas: from morphology to molecules.

Virchows Archiv : an international journal of pathology
2018

A Case of Intracranial Subependymoma: Histopathological Confirmation of Ring-shaped Lateral Ventricular Nodule.

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine
2017

TRPS1 gene alterations in human subependymoma.

Journal of neuro-oncology
2017

Anti-NMDAR encephalitis combined with a subependymoma.

Neurology India
2017

Intracranial Subependymoma: A SEER Analysis 2004-2013.

World neurosurgery
2016

Bamboo Leaf Sign as a Sensitive Magnetic Resonance Imaging Finding in Spinal Subependymoma: Case Report and Literature Review.

Case reports in neurological medicine
2017

MR Spectroscopy to Distinguish between Supratentorial Intraventricular Subependymoma and Central Neurocytoma.

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine
2016

Conversion technique from neuroendoscopy to microsurgery in ventricular tumors: Technical note.

Surgical neurology international
2017

Supratentorial Parenchymal Ependymomas in Children: Experience with 14 Patients at a Single Institute.

Turkish neurosurgery
2016

Malignant Transformation in Glioma Steered by an Angiogenic Switch: Defining a Role for Bone Marrow-Derived Cells.

Cureus
2016

Ependymoma: a heterogeneous tumor of uncertain origin and limited therapeutic options.

Handbook of clinical neurology
2016

Neuroradiological features of cervical and cervicothoracic intraspinal subependymomas: a study of five cases.

Clinical radiology
2016

Minimally Invasive Transsulcal Resection of Intraventricular and Periventricular Lesions Through a Tubular Retractor System: Multicentric Experience and Results.

World neurosurgery
2015

Primary spinal primitive neuroectodermal tumor on MR imaging.

The Indian journal of radiology &amp; imaging
2015

[A Rare Case of Subependymoma of the Septum Pellucidum as Intratumoral Hemorrhage].

No shinkei geka. Neurological surgery
2016

Findings from frozen sections of spinal subependymomas: Is it possible to differentiate this diagnosis from other common spinal tumors?

Brain tumor pathology
2015

Water Channels Aquaporin 4 and -1 Expression in Subependymoma Depends on the Localization of the Tumors.

PloS one
2015

Recurrent subependymoma of fourth ventricle with unusual atypical histological features: A case report.

Pathology international
2015

Subependymoma with extensive microcystic transformation: a case report.

International journal of clinical and experimental pathology
2015

Fluorescence-guided resection with 5-aminolevulinic Acid of subependymomas of the fourth ventricle: report of 2 cases: technical case report.

Neurosurgery
2015

Cavernoma of the septum pellucidum in the region of foramen of Monro.

Neurology India
2016

Subependymoma of septum pellucidum presenting with cough and exertional headache: a case report of spontaneous regression after incomplete surgical removal.

Journal of neurosurgical sciences
Ver todos os 214 no EuropePMC

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Incidental Subependymoma of the Floor of the Fourth Ventricle: A Case Report.
    Cureus· 2026· PMID 41835777mais citado
  2. Two pediatric supratentorial ependymal tumors with novel PLAG1 fusions.
    Acta neuropathologica communications· 2026· PMID 41639901mais citado
  3. Ependymal Tumors.
    Neuroimaging clinics of North America· 2026· PMID 41274771mais citado
  4. Resection of a Cerebellopontine Angle Ependymoma Using a Far Lateral Approach: 2-Dimensional Operative Video.
    Operative neurosurgery (Hagerstown, Md.)· 2026· PMID 40298388mais citado
  5. Aggressive biological behavior of benign central nervous system neoplasms: The case of hemorrhagic subependymomas - An illustrated review.
    Surgical neurology international· 2025· PMID 41625122mais citado
  6. Brainstem tumors with subependymoma-like morphology and H3K27M mutation are epigenetically distinct.
    J Neuropathol Exp Neurol· 2025· PMID 41411016recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:251639(Orphanet)
  2. MONDO:0007667(MONDO)
  3. GARD:10070(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Q18556497(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Subependimoma
Compêndio · Raras BR

Subependimoma

ORPHA:251639 · MONDO:0007667
Prevalência
<1 / 1 000 000
CID-10
D43.2 · Neoplasia de comportamento incerto ou desconhecido do encéfalo, não especificado
CID-11
Início
Adult
Prevalência
0.0 (Europe)
MedGen
UMLS
C0206725
Repurposing
1 candidato
carmustineDNA alkylating agent|DNA inhibitor
EuropePMC
Wikidata
Papers 10a
Evidência
🥉 Relato de caso
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