Metabolic reprogramming induced by CRP deficiency or human CRP transgenic in influenza-infected mice.

Integrated multi-omics analyses elucidate the key regulatory networks in response to Tomato brown rugose fruit virus infection in Solanum lycopersicum L.

Investigating the role of FKBP4 in testis germ cell tumor via integrated in silico approach.

Microglia cause HIV-induced transcriptional and metabolic changes in human neural organoids.

Fusarium oxysporum f. sp. cubense Race 4 Effector, Foc4-305, Targets a Proline-Rich Protein in Banana and Contributes to Virulence.

Bacillus amyloliquefaciens induces autophagy-mediated defense, phytohormonal modulation, and metabolic reprogramming in Oryza sativa to counteract Rhizoctonia solani sheath blight.

Elucidating the Anti-thrombotic Mechanism of Equiseti hiemalis Herba through Integrated Pharmacology.

The ROS-triggered antibacterial mechanism of zinc oxide nanoparticles against Xanthomonas citri subsp. citri for citrus canker management.

Arginine improves growth and health status of post-larval Litopenaeus vannamei by modulating amino acid metabolism and enhancing antioxidative defense.

Mass drug administration of praziquantel lowers the susceptibility of school-aged children to Schistosoma mansoni in endemic areas.

Fluorogenic Ligand Enables Identification of NSD3-Overexpressed Tumors by Targeting the PWWP1 Domain of NSD3.

Early administration of renin-angiotensin system inhibitors improves survival and cardiac remodeling in heart failure with preserved ejection fraction.

Integrated Genome-wide Association and Single-cell Transcriptomic Analysis Identifies OAT as Therapeutic Targets for Periodontitis.

Proteomic mapping of Rosa damascena nanovesicles reveals plastid mitochondrial metabolic convergence and antimicrobial peptides.

A synbiotic combination of arabinogalactan and Bacteroides thetaiotaomicron ameliorates ulcerative colitis in mice.

Chronic Pyraclostrobin Exposure-Induced Developmental Toxicity and ABC Transporter-Associated Metabolism Disorders during Zebrafish Embryo-Larval Stages.

Proline/serine-rich coiled-coil 1 alleviates atherosclerosis via remodeling tryptophan metabolism mediated by Akkermansia muciniphila.

Small proline-rich protein 1A is a novel target of peroxisome proliferator-activated receptor gamma in steatotic liver disease.

Evaluating the Impact of Phosphorylation on the Dynamics of the Tau Protein Proline-Rich Region.

Sex-based multiomics analysis uncovers metabolic and molecular mediators linking MASH and atherosclerosis.

Serum Prolidase Activity and its Association with Oxidative Stress and Inflammation in Silicosis.

Ultra-performance liquid chromatography-mass spectrometry analysis of post-mortem brain tissue reveals specific amino acid profile dysregulation in Parkinson's disease and Alzheimer's disease patients.

Red Blood Cell Metabolomic Signatures in β-Thalassemia Heterozygotes With Elevated HbA1c: Implications for Biomarkers and Personalized Medicine.

Multilayer Timing of Cardiac Circadian Regulation Informs Prevention and Treatment of Cardiovascular Disease.

Loss of Nonhematopoietic Osteopontin Weakens the Intestinal Barrier and Alters the Microbiome and Metabolome in Mice.

Metabolomics biomarkers for precision psychiatry.

Integrated pathological assessment and multi-omics analysis of the effects of Pinellia ternata aqueous extract on lung and spleen dysfunction in a rat model of phlegm-dampness obstruction.

Nontargeted screening identifies mixtures of environmental pollutants that are associated with perturbations to amino acid and fatty acid metabolic pathways during early pregnancy.

The causal association between plasma amino acid levels and abdominal aortic aneurysm: insights from Mendelian randomization and an experimental validation.

P4HA2 Participates in Pathogenesis of Refractive Error by Regulating Collagen Posttranslational Modification and Extracellular Matrix Balance.

Prolyl tRNA Synthetase Is Required for Mammarenavirus Multiplication.

Prolyl 3-Hydroxylase 2 Supports a Pro-Angiogenic Milieu Promoting Colorectal Cancer Progression and Metastasis.

Lower serum threonine and glutamine levels could be a predictor for multiple sclerosis in pregnancy.

Enhanced Biocontrol of Root-Knot Nematodes Through Co-Cultivation of Clonostachys rosea and Bacillus velezensis: Proline-Driven Bacterial Fitness and Synergistic Metabolite Production.

Proline-Mediated Inhibition of ATPIF1-mTOR Signaling Alleviates Radiation-Induced Macrophage Polarization and Colon Inflammation.

A gated hydrophobic funnel within BAX binds bioactive lipids to potentiate pro-apoptotic function.

Nutrient microenvironments reprogram RPE metabolism.

Microbiome- metabolome signatures and Behavioral alterations in a progressive MPTP-induced mouse model of Parkinson's disease.

Nontargeted metabolomics analysis of potential biomarkers for patients with chronic ischemic stroke in extremely cold rural regions: An exploratory case-control study.

Maternal Toxoplasma gondii Infection Perturbs Foetal and Maternal Foetal Interface Metabolism, Exposing the Foetus to Kynurenine.

Quantification of D-Amino Acids in Type 1 Diabetes-Affected Human Serum.

Targeted serum metabolomics reveals alterations in amino acid and neurotransmitter pathways in Parkinson's disease.

Gyrate atrophy of the choroid and retina: a tertiary center experience.

C9orf72-derived dipeptide repeat proteins poly-PR disrupt membrane excitability and synaptic function in cortical neurons.

2-Ethylhexanol inhibit Botrytis cinerea by interfering in sugar and amino acid metabolism.

Discovery of first-in-class melanostatin-based ago-allosteric modulators of the dopamine D2 receptors.

PRR15 suppresses renal cell carcinoma progression via the NF-κB/FDX1 axis to induce cuproptosis and mitochondrial dysfunction.

Echinoderm collagen as a neuromodulatory antioxidant: biochemical characterization and molecular interaction with NMDA receptor.

Optimal preclinical models for human dose projection of SARS-CoV-2 small molecule direct-acting antivirals.

Association Between Diet and Metabolome in Childhood and Adolescence: A Systematic Review.

Integrating virtual screening and molecular dynamics simulations to identify emodin as a PYCR1 inhibitor modulating docetaxel sensitivity in prostate cancer.

Rising Star: G Protein-coupled Receptors (GPCRs) in Microenvironment Pharmacology and Sensory Perception Pharmacology.

Targeted CSF metabolomics and conformal prediction improve diagnostic accuracy of normal pressure hydrocephalus.

Integrative metabolomic and single-cell transcriptomic analysis of recurrent condyloma acuminatum in humans.

Gut microbial ammonia as a mediator of PFOS neurotoxicity and its remediation by the flavonoid Icaritin.

Pharmacokinetics, pathology and efficacy of SARS-CoV-2 main protease inhibitor VPC285785 in a murine model of coronavirus infection.

Analysis of genetic mutation distribution and metabolic characteristics in patients with primary carnitine deficiency from the Ganzhou area, China.

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism.

The mechanism of acetyl-L-carnitine on colorectal cancer and its metabolomic study.

Plant-derived extracellular vesicles as a dual-function nanoplatform for synergistic neurovascular repair in ischemic stroke.

Bacillus velezensis Yao Suppresses Fusarium Solani-Induced Pepper Root Rot via Fengycin and Induces Systemic Resistance.

Case Report: Hyperprolinemia type II in a child with autism spectrum disorder and ALDH4A1 gene variant in a consanguineous family.

Alteration in Amino Acid Metabolism After Isocaloric, Energy-Restricted Ketogenic Diet in Women with Overweight and Obesity: Randomized KETO-MINOX Trial.

Seed Oil of Lycium barbarum L. from Qaidam Basin Prevents and Treats UV-Induced Photodamage in BABL/c Mice Skin by Modulating Skin Microbiome and Amino Acid Metabolism.

Metabolomic profiling of cocaine plus ethanol poly-consumption in young adult rats: Insights into the incubation of drug seeking.

The genetic fusion of thaumatin-like proteins with antimicrobial peptides or receptor-like kinases at different evolutionary time points contributes to plant resistance against Sclerotinia disease.

APM⁺ macrophages associated with plaque vulnerability via MIF-CD74 signaling: a multi-omics study.

Mutations in the Aβ42 Recognition Sequence KLVFF Afford New Pentapeptide Inhibitors of Aβ42 Fibrillation: Computation-Driven Rational Design and Experimental Validation.

The R451 site is critical for PTPN18 to exert tumor suppressive effects in breast cancer through the negative regulatory interacting protein fibrillarin.

Absorption, distribution, metabolism, and excretion tactics toward the expedited discovery and development of the severe acute respiratory syndrome coronavirus-2 main protease inhibitor nirmatrelvir.

Shifts in amino acids profile in chronic pancreatitis.

Metabolic Alterations Induced by a Seizure-Causing Sodium Channel Mutation and their Partial Normalization by Dietary α-Linolenic Acid in Drosophila.

SH3 domains selectively activate the PI3 kinase through non-conventional tertiary contacts.

Parental glyphosate exposure primes tomato offspring for enhanced growth and stress tolerance.

Rapid, non-invasive diagnosis of tuberculosis using desorption separation ionization mass spectrometry (DSI-MS) and urinary carbonyl metabolite fingerprints.

Integrated Proteomic and Metabolomic Profiling for Developing Novel Plasma-Based Diagnostic Models of Sarcopenia.

<p>Prolyl hydroxylase domain proteins: Localization, regulation, function and their role in erythropoiesis (Review)</p>.

Effect of the ACE inhibitor Zofenopril on the Oxidative Status of the Eye in Animals with Experimental Glaucoma.

Vasoactive Effects of Chronic Treatment with ACE Inhibitor Zofenopril in Zucker Obese Diabetic Rats: The Role of Nitroso and Sul?de Signalization.

Targeting SPAK suppresses progression and averts an immune exhaustive microenvironment in hepatocellular carcinoma.

Nitrilotriacetic acid functionalized gold nanopillars enable stochastic detection and deep learning analysis of prolines and hydroxyprolines by surface enhanced Raman spectroscopy.

Transcriptomic signature-guided depletion of intermediate alveolar epithelial cells ameliorates pulmonary fibrosis in mice.

Molecular basis and cellular effects of Janus-class-driven cytoplasmic PYK2 coacervates.

A mouse model of a patient derived P544L mutation in the Slc6a8 gene shows hypoactivity and cognitive deficits.

Investigating causal associations between serum metabolites and cataract by Mendelian randomization.

Executive Summary of the KDIGO 2026 Clinical Practice Guideline for the Management of Anemia in Chronic Kidney Disease (CKD).

Socioeconomic Differences in Nutrient Intake, Metabolite Profiles, and Blood Pressure: The African-PREDICT Study.

Qi-Fu-Yin ameliorates physiological frailty in male 5xFAD mice through remodeling the gut microbiota and modulating the cerebral cortex metabolism.

The metabolomic profile of psoriatic arthritis patients unveils the unbalance of disease-related molecules and pathways.

Development of the fluorescence polarization-based competition assay for the E3 ligase GID4.

Rhizosphere-derived Stutzerimonas stutzeri AUMC B-503: a promising biocontrol and plant growth-promoting strain for managing brown spot disease in rice (Oryza sativa).

Effect of IFN-τ on intestinal flora and metabolomics of Escherichia coli-mediated endometritis in mice.

NDRG1-HIF1α interaction in hypoxic signaling for pulmonary hypertension.

Gut microbiota combined with metabolomics approach to investigate the processing-based detoxification mechanism of processed cream of Croton tiglium L. seeds.

The effect of Tannic acid on colonic anastomosis in abdominal sepsis: An experimental study.

First exposure to second-generation antipsychotics alters gut microbiota and metabolic profiles in patients with glucose-lipid metabolism disorders.

Cross-species analysis of FcγRIIa/b (CD32a/b) polymorphisms at position 131: structural and functional insights into the mechanism of IgG- mediated phagocytosis in human and macaque.

Comparison of gastric mucosa microbiota in metabolically healthy and unhealthy obesity.

Roxadustat induces erythroid differentiation of erythroleukemia cells through the hypoxia inducible factor-α/GATA binding protein 1 axis.

Antiviral potential of crude extracts from two Streptomyces spp. against Cucumber Mosaic Virus infection under greenhouse conditions.

Localization of mutant huntingtin with HTT Exon1 P90 C-terminal neoepitope antibodies in relation to regional and neuronal vulnerability in forebrain in Q175 mice and human huntington's disease.

An interpretable metabolomic-driven machine learning model for early prediction of knee structural OA progression.

Metabolomic Changes After Bariatric Surgery Adjusted for Glomerular Filtration Rate Suggest Mechanisms of Kidney Protection.

Plasma untargeted metabolomics reveals the metabolic landscape of NKTCL and aids in liquid biopsy for disease detection.

Effects of alendronate and vitamin D on plasma metabolomic profiles in a rat model of osteoporosis.

Chronotype, serum metabolome, and nonalcoholic fatty liver disease in middle-aged and older adults: Association and potential mediation analyses.

Gut microbiome-metabolome dysregulation in systemic sclerosis: a multi-omics study.

Endothelial Dysfunction Contributes to Chondrocyte Senescence Associated With Insulin-Like Growth Factor-Binding Protein-6 in a Spontaneously Hypertensive Rat Model.

Serum Metabolomic Signatures of Dyslipidemia in Narcolepsy Type 1: A Multi-Center Cross-Sectional Study.

Bifidobacterium animalis subsp. lactis Bbm-19 ameliorates insomnia by remodeling the gut microbiota and restoring γ-aminobutyric acid and serotonin signaling.

Epitope-specific antibodies can distinguish between soluble huntingtin exon-1 and its diverse cellular aggregates.

Levan induced the resistance of tomato against Botrytis cinerea and pepper against Phytophthora capsici.

Brusatol inhibits gastric cancer by targeting P4HA2 and supressing glycolysis-driven histone lactylation.

Serum Metabolites and Heart Failure Risk: MESA and RS.

Metabolic Predictors of CAD: Focus on Cystine, Methionine, Proline, and Threonine Circulating Levels-Exploratory Pilot Study.

Integrated multi-omics reveals terpenoid-driven metabolic and transcriptional regulation underlying sweetpotato resistance to black rot disease.

Integrated salivary microbiome and metabolome profiling reveals ecological and functional alterations in severe early childhood caries.

Iron status mediates the causal effects of high-altitude adaptation signals in the HIF-PHD axis on pulmonary vascular and right-heart outcomes.

The effect of SGLT2 inhibitor and HIF-PHI on the podocyte-specific molecules and cytoskeleton of diabetic podocytes.

Dysregulation of argininosuccinate synthase 1, phosphoenolpyruvate carboxykinase 1, and carbonyl reductase 3: Key arginine-proline metabolic mediators in mesangioproliferative glomerulopathies.

Amyloid-motif-dependent tau self-assembly is modulated by isoform sequence context.

Probing tau citrullination in Alzheimer's disease brains and mouse models of tauopathy.

The dihydropyridine LA1011 modulates multiple Hsp90-co-chaperone interactions relevant to Alzheimer's disease.

Structural insights into AVR-Rmg8 recognition mechanisms by the wheat blast resistance gene Rmg8.

Comparative effectiveness of hypoxia-inducible factor prolyl hydroxylase inhibitors versus erythropoiesis-stimulating agents on prognosis in non-dialysis chronic kidney disease: a propensity-matched cohort study.

Oxidative hypoxia drives TGF-β1-induced fibrosis under normoxia.

Plasma amino acid profile in obese children, adolescents, and adults: similarities or differences - a narrative review.

A Thin Film Micro-Extraction Based Salivary Metabolomics and Chemometric Strategy for Rapid Lung Cancer Diagnosis.

Integrated metagenome and metabolome analysis reveals a disease signature of gut microbiota and the key gut microbiota-associated metabolite proline in schizophrenia.

A fly model of SCA36 reveals combinatorial neurotoxicity of hexanucleotide and dipeptide repeats.

Proline transporters balance the salicylic acid-mediated trade-off between regeneration and immunity in plants.

LINC02878/ZNF282/PYCR2 axis promotes proline synthesis and tumor progression in colorectal cancer.

Cntn4 Gene Deficiency Promotes Autism-Like Phenotypes Associated with Gut Microbiota Perturbations and Gut-Brain Axis Metabolomic Alterations in Mice.

Metabolomic Relationships Between Lung Cancer and Alzheimer's Disease Using Serum Nuclear Magnetic Resonance Spectroscopy.

Sustainable approaches to manage fusarium root rot in faba bean.

Phosphorylation of the β2 integrin subunit CD18 contributes to Actinobacillus pleuropneumoniae ApxI-induced cytotoxicity through the downregulation of Akt activity.

The MAB_3513c gene plays a key role in intrinsic resistance of Mycobacterium abscessus to isoniazid and ethionamide.

Integrated Transcriptomic and Physiological and Biochemical Analysis Revealed Response Mechanism of Rice (Oryza sativa L.) to Methylmercury Toxicity Stress.

Unveiling the Structure of PROT and ATB0,+: Unique Members of the Glycine Transporter Subfamily.

Cullin 2 Elevates the Warburg Effect to Accelerate the Development of Hypoxic Pulmonary Hypertension.

Quantification of plasma tau species containing the proline-rich region as a biomarker in Alzheimer's disease.

Systemic and skeletal muscle metabolic signatures associated with early insulin resistance in just-weaned non-obese Goto-Kakizaki diabetic rats.

Immunogenic Streptococcus equi cell surface proteins identified by ORFeome phage display.

An intrabody targeting PHD2 protects mice against acetaminophen-induced liver injury by attenuating ferroptosis.

Effects of a Gain-of-Function Mutation in the Voltage-Gated Sodium Channel Gene, and of Dietary α-Linolenic Acid Supplementation, on Whole-Body Metabolism in Drosophila.

The effects of combined low-dose cadmium and deltamethrin on mitochondrial bioenergetics and metabolism in human lung fibroblasts.

Dual Hyaluronidase Genes hysA and hysAνSaβ Enhance MRSA ST398 Skin Infection.

The P4HA1/HIF1α feedback loop modulates endothelial dysfunction in pulmonary hypertension.

A SARS-CoV-2 Mpro mutation conferring ensitrelvir resistance paradoxically increases nirmatrelvir susceptibility.

Emerging roles of arginine metabolism in skeletal health and disease.

Serum analysis of type 2 diabetes mellitus patients with low, moderate, and high risk of diabetic kidney disease using LC-MS metabolomics approach.

Bacillus subtilis and chitosan nanoparticles enhance potato virus Y (PVY) tolerance in tomato (Solanum lycopersicum L.) via modulation of antioxidants and secondary metabolites.

Multidimensional engineering strategies for strengthening exogenous synthesis of collagens and elastin monomers.

Effect of OmpA of Acinetobacter baumannii on apoptosis in pulmonary epithelial cells and its molecular mechanism.

Improvement of chilling tolerance and postharvest quality in mango fruit by pre-storage dopamine application.

Oral L-Arginine treatment attenuates Cryptococcus neoformans extrapulmonary dissemination and disease progression.

PYCR1 drives lung cancer progression through functional interactions with EGFR and TLR signaling pathways.

Effects of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors on Relationship Between B-Type Natriuretic Peptide and Hemoglobin Levels in Patients With Cardiorenal Anemia Syndrome.

Metabolomic Profiling by UPLC-QTOF/MS Reveals Potential Biomarkers and Metabolic Alterations in Pediatric Septic Shock.

Click-Cyclized Cell Penetrating Peptides Containing Hydrophobic Proline Derivatives for Efficient Intracellular Delivery.

Glutamine metabolism reprogramming promotes bladder cancer progression via PYCR1: a multi-omics and functional validation study.

MT-ATP6 variant as a cause of adult-onset hereditary spastic paraparesis: A case report and literature review.

Ca2+-driven PDIA6 biomolecular condensation ensures proinsulin folding.

Characterizing gut microbiota and fecal metabolites in intervertebral disc degeneration: insights into the gut-disc axis.

The MYO1F interactome reveals ASAP1, CD2AP and SH3KBP1 as novel adaptor proteins in podosomes and phagosomes.

Molecular mechanisms of cold stress-induced lens opacity: An investigation through multi-omics integrative analysis.

Emerging Roles of De Novo Proline Biosynthesis in Human Diseases.

Investigating the conformational landscape of human histidine-rich glycoprotein using amide HDX-MS.

Dietary amino acids and the odds of metabolic dysfunction-associated fatty liver disease (MAFLD) among overweight and obese children and adolescents: a principal component analysis approach.

Physiological responses of Marsol and CA-90 chestnut plants to high temperature and water scarcity co-exposure: a comparative study.

[Ac-SDKP antagonizes lung fibrosis through EGFR/STAT3 pathway in silicosis rats].

Model-Informed Drug Development for Daprodustat Supports the Design of Individualized Dosing Regimens in Chronic Kidney Disease Patients With Anemia.

Loss of arginase 2 disrupts striatum-specific polyamine homeostasis.

Exploring the Causal Relationship Between Blood Metabolites and Chronic Periodontitis: Insights From Genetic Causal Analysis.

Guben-Qushi-Huayu formula and calycosin improve epidermal barrier function in psoriasis by inhibiting small proline-rich protein 1A.

The Interaction of PELP1 With FHL2 Contributes to Ectopic Endometrial Stromal Cell Proliferation, Angiogenesis, and Inflammation in Endometriosis.

Comprehensive analysis of metabolic and molecular alterations in the blood of patients with Sjögren's syndrome based on untargeted metabolomics analysis.

The C-terminal tails of GroEL and its mitochondrial and chloroplastic homologs adopt polyproline II helices.

Unveiling the mechanisms of Inonotus hispidus against polycystic ovary syndrome: An integrated metabolomics and network pharmacology approach in vivo and vitro.

Metabolic reprogramming of hippocampal endothelial cells contributes to blood-brain barrier dysfunction in perioperative neurocognitive disorder.

Biological Peptides, Metabolites and Nanoparticles from Potassium-Solubilizing Bacteria: A Recent Horizon in Antimicrobial and Anti-biofilm Strategies.

Non-invasive hair metabolome analysis reveals GERD and thyroid dysfunction in pulmonary fibrosis patients.

Splicing and frameshift variants in QSER1 may be involved in developmental phenotypes.

Eicosapentaenoic Acid Modulates 3-Chloro-1,2-propanediol Dipalmitate Ester-Induced Disrupted Metabolism: A Dual-Approach Analysis Using Nontargeted Metabolomics and Computational Modeling.

Pharmacological inhibition of SPAK-NKCC1 complex attenuates astrogliosis and restores cerebral blood flow in a mouse model of VCID.

Captopril restores microglial homeostasis and reverses ASD-like phenotype in a model of ASD induced by exposure in utero to anti-caspr2 IgG.

Oxidized angiotensin II peptides as mediators of cell signaling?

Stabilisation of HIF signalling in the mouse epicardium extends embryonic potential and neonatal heart regeneration.

A missense variant in the KH0-domain of FMRP downregulates the protein in a patient with the clinical hallmarks of fragile X syndrome.

Pediococcus acidilactici PA-1 Alleviates Diet-Induced Obesity by Modulating Hepatic Amino Acid Metabolism and Gut Microbiota in Mice.

Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1α oxygen-dependent degradation domain.

Multi-omics data improves one-year mortality prediction in acute heart failure.

Associations between circulating amino acids and hepatic steatosis indices in Iranian adults aged over 50: findings from the Bushehr elderly health (BEH) program.

Metabolic changes in root exudates of plants with different disease severity affect plant resistance by regulating the rhizosphere microbiome.

Paclitaxel resistance-associated metabolic events in ovarian cancer cells.

Role of N,N,N Trimethyl-L-alanyl-L-proline Betaine Levels in the Process of Myocardial Infarction.

Yiai Fuzheng decoction inhibits triple-negative breast cancer by remodeling the immune microenvironment.

Identification of biomarkers in gynecologic cancers: a machine learning approach for metabolomics.

Proline Metabolism in Cancer: Emerging Roles in Redox Homeostasis and Therapeutic Opportunities.

Enhanced Collagen Prolyl 4-Hydroxylase Activity and Expression Promote Cancer Progression via Both Canonical and Non-Canonical Mechanisms.