Raras
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Enterocolite necrotizante
ORPHA:391673CID-10 · P77CID-11 · KB88DOENÇA RARA

A enterocolite necrosante (ECN) é uma doença devastadora que afeta principalmente o intestino de bebês prematuros. A parede do intestino é invadida por bactérias, que causam infecção local e inflamação que pode destruir a parede do intestino (intestino). Essa destruição da parede intestinal pode levar à perfuração do intestino e ao derramamento de fezes no abdômen do bebê, o que pode resultar em uma infecção avassaladora e morte.

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Introdução

O que você precisa saber de cara

📋

A enterocolite necrosante (ECN) é uma doença devastadora que afeta principalmente o intestino de bebês prematuros. A parede do intestino é invadida por bactérias, que causam infecção local e inflamação que pode destruir a parede do intestino (intestino). Essa destruição da parede intestinal pode levar à perfuração do intestino e ao derramamento de fezes no abdômen do bebê, o que pode resultar em uma infecção avassaladora e morte.

Pesquisas ativas
27 ensaios
237 total registrados no ClinicalTrials.gov
Publicações científicas
10.131 artigos
Último publicado: 2026

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
1-5 / 10 000
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
45.0
Worldwide
Início
Neonatal
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: P77
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Entender a doença

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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🫃
Digestivo
7 sintomas
❤️
Coração
3 sintomas
🩸
Sangue
3 sintomas
🫁
Pulmão
1 sintomas

+ 20 sintomas em outras categorias

Características mais comuns

90%prev.
Nascimento prematuro
Muito frequente (99-80%)
55%prev.
Diarreia sanguinolenta
Frequente (79-30%)
55%prev.
Pequeno para a idade gestacional
Frequente (79-30%)
55%prev.
Leucocitose
Frequente (79-30%)
55%prev.
Cianose
Frequente (79-30%)
55%prev.
Diarreia
Frequente (79-30%)
34sintomas
Muito frequente (1)
Frequente (12)
Ocasional (21)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 34 características clínicas mais associadas, ordenadas por frequência.

Nascimento prematuroPremature birth
Muito frequente (99-80%)90%
Diarreia sanguinolentaBloody diarrhea
Frequente (79-30%)55%
Pequeno para a idade gestacionalSmall for gestational age
Frequente (79-30%)55%
LeucocitoseLeukocytosis
Frequente (79-30%)55%
CianoseCyanosis
Frequente (79-30%)55%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico10.131PubMed
Últimos 10 anos200publicações
Pico2026134 papers
Linha do tempo
2026Hoje · 2026🧪 1993Primeiro ensaio clínico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
Aprovado2
2Fase 22
·Pré-clínico16
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 20 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Enterocolite necrotizante

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

11 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

Outros ensaios clínicos

237 ensaios clínicos encontrados, 27 ativos.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

🥉Melhor nível de evidência: Relato de caso
Timeline de publicações
5.507 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 5.507

#1

CD177⁺ neutrophil-platelet aggregates contribute to thromboinflammation via NETs in necrotizing enterocolitis.

Nature communications2026 Mar 19

Este estudo revela que a Enterocolite Necrosante (NEC) em prematuros é impulsionada por um processo de "tromboinflamação" intestinal, onde agregados específicos de neutrófilos CD177+ e plaquetas (NPAs) são os principais causadores de lesão. Os níveis elevados desses agregados (CD177+ NPAs) podem servir como importantes biomarcadores para diagnosticar e monitorizar a gravidade da doença. Adicionalmente, o tratamento com heparina de baixo peso molecular (LMWH) mostrou potencial para prevenir a formação desses agregados e reduzir a gravidade da NEC em modelos experimentais, apontando para novas estratégias de tratamento e prevenção.

🇧🇷 traduzido
#2

Impact of a Structured Brain Care Bundle on Severe Germinal Matrix Hemorrhage-Intraventricular Hemorrhage in Very Preterm Neonates: A Retrospective Cohort Study.

Pediatric neurology2026 Feb 23

Este estudo demonstrou que a implementação de um "Pacote de Cuidados Cerebrais" (BCB) estruturado em unidades neonatais para bebês muito prematuros reduziu significativamente a hemorragia intraventricular grave (GMH-IVH) – caindo de 15% para 5% – e também diminuiu acentuadamente a sepse de início tardio. Estes resultados são importantes para médicos e pais, pois sugerem que a adoção de BCBs é uma estratégia eficaz para proteger o desenvolvimento neurológico e a saúde geral de recém-nascidos vulneráveis.

🇧🇷 traduzido
#3

Role of melatonin for prevention of necrotizing enterocolitis in preterm infants: a randomized controlled trial.

Journal of tropical pediatrics2026 Feb 09

Este estudo demonstrou que a administração de melatonina por via oral pode reduzir significativamente a incidência de enterocolite necrosante (NEC) e a mortalidade em bebês prematuros com intolerância alimentar. A terapia também acelerou o alcance da alimentação enteral completa e diminuiu marcadores inflamatórios. Isso sugere que a melatonina é uma opção de tratamento prática, acessível e potencialmente vital para melhorar os desfechos desses pacientes.

🇧🇷 traduzido
#4

Loss of polarity by Cdc42 depletion and oncogenic Kras activation in the mouse intestinal epithelia leads to a necrotizing enterocolitis (NEC)-like disease.

Nature communications2026 Mar 18

Este estudo em camundongos sugere que a perda da polaridade celular, combinada com a ativação do gene Kras oncogênico, pode ser uma causa fundamental para o desenvolvimento de uma doença semelhante à enterocolite necrosante (NEC), caracterizada por inflamação e morte celular grave no intestino. Mais importante para pacientes e médicos, a pesquisa identificou que a supressão de vias de sinalização específicas (como YAP, IL-1 e TNFα) ou da morte celular por necroptose conseguiu reverter essa patologia intestinal, abrindo portas para novas abordagens terapêuticas para a NEC.

🇧🇷 traduzido
#5

Clostridia from preterm infants metabolize human milk oligosaccharides to suppress pathobionts and modulate intestinal function in organoids.

Nature microbiology2026 Mar 16

Focando na proteção de bebês prematuros contra a enterocolite necrosante (ECN), este estudo revela que um tipo específico de bactéria, *Clostridium perfringens* (sem a toxina perfringolisina O), isolada de prematuros, também metaboliza os oligossacarídeos do leite humano (HMOs). Ao fazer isso, essas bactérias produzem metabólitos benéficos, promovem o crescimento de bactérias saudáveis e inibem patógenos, além de reduzir a inflamação intestinal. Isso sugere um novo e promissor mecanismo pelo qual certas cepas de *Clostridia* podem contribuir significativamente para proteger a saúde intestinal de bebês prematuros e prevenir a ECN.

🇧🇷 traduzido

Publicações recentes

Ver todas no PubMed

📚 EuropePMC4.363 artigos no totalmostrando 198

2026

Rethinking probiotic delivery: new hope for preventing necrotizing enterocolitis.

Expert opinion on drug delivery
2026

Trends in Survival and Short-Term Outcomes Among Preterm Infants Less Than 32 Weeks From 2016 to 2022: A Retrospective Cohort Study at a Tertiary Medical Center in the UAE.

Cureus
2026

CD177⁺ neutrophil-platelet aggregates contribute to thromboinflammation via NETs in necrotizing enterocolitis.

Nature communications
2026

Impact of a Structured Brain Care Bundle on Severe Germinal Matrix Hemorrhage-Intraventricular Hemorrhage in Very Preterm Neonates: A Retrospective Cohort Study.

Pediatric neurology
2026

Predicting the Risk of Reoperative Intervention for Adhesive Bowel Obstruction in Neonates: The Neonatal Adhesion Risk Score (NARS).

Journal of pediatric surgery
2026

The role of mesencephalic astrocyte-derived neurotrophic factor in digestive diseases.

Annals of medicine
2026

Role of melatonin for prevention of necrotizing enterocolitis in preterm infants: a randomized controlled trial.

Journal of tropical pediatrics
2026

Loss of polarity by Cdc42 depletion and oncogenic Kras activation in the mouse intestinal epithelia leads to a necrotizing enterocolitis (NEC)-like disease.

Nature communications
2026

Clostridia from preterm infants metabolize human milk oligosaccharides to suppress pathobionts and modulate intestinal function in organoids.

Nature microbiology
2026

The role of myeloid cells in the pathogenesis of necrotizing enterocolitis; a scoping review.

Frontiers in pediatrics
2026

Short Antibiotic Treatment for Coagulase-negative Staphylococcal Sepsis in Premature Infants: A Multicenter Noninferiority Study.

The Pediatric infectious disease journal
2026

Amino acid-based formula and feeding outcomes in preterm infants with recurrent intolerance: A propensity score-matched study.

Nutrition (Burbank, Los Angeles County, Calif.)
2026

A Novel Rapid 3D Tissue-Clearing and Staining Approach for Enteric Neurovascular Imaging and Pathology Applications.

Diagnostics (Basel, Switzerland)
2026

Identification of the expression of tRNA-derived small RNAs associated with necrotizing enterocolitis.

Pediatric research
2026

Improving preoperative enteral feeding for newborns with congenital heart disease.

Journal of perinatology : official journal of the California Perinatal Association
2026

Association between risk-adjusted mortality and severe morbidity in very low birth weight infants: a multicenter study from the NEOCOSUR network.

Journal of perinatology : official journal of the California Perinatal Association
2026

The impact of Assisted Reproductive Technology on the neonatal prognosis of newborns < 29 weeks gestational age: a retrospective case-control study.

Journal of gynecology obstetrics and human reproduction
2026

Single-center experience with pediatric short bowel syndrome: clinical outcomes based on etiology and anatomical type in a retrospective cohort study.

Annals of surgical treatment and research
2026

Applications of artificial intelligence in pediatric general surgery: a systematic review.

Translational pediatrics
2026

Risk factors and prevalence of retinopathy of prematurity in very low birth weight preterm infants: a systematic review and meta-analysis.

Translational pediatrics
2026

A Prospective-Retrospective Observational Cohort Study of Short-Term Health Outcomes of Preterm Very Low Birth Weight Infants Receiving Oropharyngeal Administration of Own Mother's Colostrum.

Current therapeutic research, clinical and experimental
2026

Early Diagnosis of Atypical Necrotizing Enterocolitis in Preterm Infants Using Point-of-Care Liver Ultrasound for Portal Venous Gas.

Journal of clinical ultrasound : JCU
2026

Mesenchymal stromal cell therapy restores intestinal integrity and attentuates inflammation in a preterm piglet model of necrotizing enterocolitis.

Pediatric surgery international
2026

High-Frequency Oscillation vs Mechanical Ventilation for Neonatal Acute Respiratory Distress Syndrome: A Randomized Clinical Trial.

JAMA network open
2026

Prevalence, perinatal risk factors and clinical outcomes of respiratory Ureaplasma species colonization in hospitalized preterm infants.

Frontiers in pediatrics
2025

The role of bovine colostrum in feeding intolerance in preterm neonates: a systematic review and meta-analysis of randomized controlled trials.

Frontiers in nutrition
2026

Fortification of human milk for feeding preterm infants: What is the ideal strategy?

Seminars in fetal &amp; neonatal medicine
2026

Deficiency of interleukin-40 prevents intestinal damage in experimental necrotizing enterocolitis by inhibiting NETosis.

Cell communication and signaling : CCS
2026

Clinical exposure thresholds associated with retinopathy of prematurity in preterm infants born at high altitude.

Respiratory physiology &amp; neurobiology
2026

Negative pressure wound therapy (NPWT) in the open abdomen in a preterm newborn with necrotizing enterocolitis: case report.

Italian journal of pediatrics
2026

Decrease in healthcare-associated infection rates in preterm infants-longitudinal data from 15 years of nationwide surveillance in Germany.

Infection control and hospital epidemiology
2026

Evaluation of the prognostic nutritional index in preterm infants: A retrospective study examining its relationship with retinopathy of prematurity and clinical risk factors.

Journal of neonatal-perinatal medicine
2025

Necrotizing Enterocolitis in Term Neonates: A Retrospective Chart Review from Children's Medical Center, Tehran (2020-2023).

Archives of Iranian medicine
2026

Sepsis in neonates with necrotizing enterocolitis: outcomes and predictive model.

European journal of clinical microbiology &amp; infectious diseases : official publication of the European Society of Clinical Microbiology
2026

The high-risk minority: undetected preterm SGA disproportionately contributes to adverse outcomes in a Chinese cohort.

The journal of maternal-fetal &amp; neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
2026

Impact of feeding strategies during red blood cell transfusion on cerebral and splanchnic oxygenation in preterm infants: Randomized pilot study.

Journal of neonatal-perinatal medicine
2026

Impact of timing from last dose of dexamethasone administration to delivery, different steroid courses, and fetal number on preterm neonatal outcomes.

PloS one
2026

Planned mode of delivery and neonatal outcomes in pregnancies complicated by late-onset fetal growth restriction: a retrospective cohort study.

Archives of gynecology and obstetrics
2026

Neonatal Mortality in Low-Birth-Weight Infants in Southern Ethiopia: A Multicenter Cohort Study With Multilevel Analysis.

Sage open pediatrics
2026

[Clinical significance of neutrophil chemokines in intestinal tissue and related receptor expression in peripheral blood in neonatal necrotizing enterocolitis].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
2026

[Ultrasound diagnosis of necrotizing enterocolitis in neonates].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
2026

Does Necrotizing Enterocolitis Severity and Timing, Rather than Necrotizing Enterocolitis Itself, Drive Shunt Failure in Premature Infants with Posthemorrhagic Hydrocephalus?

The Journal of pediatrics
2026

Early lung ultrasound score combined with umbilical cord-blood procalcitonin improves 1-year prognostic stratification in preterm neonates with respiratory distress syndrome.

Frontiers in pediatrics
2026

The Angel in the Marble: Antibiotic Duration in the Neonatal Intensive Care Unit.

Antibiotics (Basel, Switzerland)
2026

Hematologic Inflammatory Indices Predict Mortality in Surgical Necrotizing Enterocolitis Among Premature Infants.

Children (Basel, Switzerland)
2026

NEC-Associated Bronchopulmonary Dysplasia and the Gut-Lung Axis in Preterm Infants.

American journal of perinatology
2026

The Role of APOL1 in Necrotizing Enterocolitis and Its Promise as a Diagnostic Biomarker.

Mediators of inflammation
2026

NEC-Net: A hybrid transformer for necrotizing enterocolitis diagnosis by lesion segmentation on abdominal X-rays.

Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
2026

Balancing therapeutic benefits and hidden risks of proton pump inhibitors in pediatric practice: a narrative review and update.

Clinical and experimental pediatrics
2026

Transcriptome, metabolome, and inflammatory and oxidative properties of Clostridium butyricum CB1002 clinical strain and its isogenic mutant Δhbd.

Applied and environmental microbiology
2026

Risk factors of necrotizing enterocolitis in very low birth weight infants: a meta-analysis.

Frontiers in pediatrics
2026

Angiogenic factors and fetal Doppler for predicting adverse pregnancy outcome in early-onset small fetuses with and without pre-eclampsia.

Ultrasound in obstetrics &amp; gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
2026

Live biotherapeutic product IBP-9414 (L. reuteri) in very low birth weight infants: the Connection Study.

Pediatric research
2026

Methodological framework for the surveillance of healthcare-associated infections in high-risk infants: the NeoIPC surveillance core module protocol.

Antimicrobial resistance and infection control
2026

Necrotizing Enterocolitis in Preterm Infants: An Inflammatory Condition at the Crossroads of Intestinal Immaturity, Dysbiosis, and Nutrition.

International journal of pediatrics
2026

Outcomes and complications of invasive versus non-invasive respiratory support in extremely preterm infants: a retrospective study.

BMC pediatrics
2026

Association between initial empirical antibiotic therapy and necrotizing enterocolitis in very preterm infants at different risk for early-onset sepsis: a multicenter cohort study.

BMC pregnancy and childbirth
2026

ACR Appropriateness Criteria® Abdominal Pain-Child.

Journal of the American College of Radiology : JACR
2026

Surgical site infections in neonates: A contemporary review.

Seminars in pediatric surgery
2026

Biomarkers for feeding intolerance in infants with complex heart defects undergoing palliation surgery.

Journal of pediatric gastroenterology and nutrition
2026

Neonatal Sepsis from 2014 to 2024: The Resurgence of Gram-Negative Rods.

The Journal of pediatrics
2026

Effects of specialized proresolving mediators on gut epithelial barrier in early life.

The Journal of pharmacology and experimental therapeutics
2026

Automatic versus manual control of oxygen and neonatal clinical outcomes in extremely preterm infants: a multicentre, parallel-group, randomised, controlled, superiority trial.

The Lancet. Child &amp; adolescent health
2026

Effectiveness of Ibuprofen Arginine, Ibuprofen Lysine, and Indomethacin for Patent Ductus Arteriosus Closure in Neonates.

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
2026

Rapid Detection of Inter-alpha Inhibitor Proteins in Neonatal Sepsis and Necrotizing Enterocolitis.

medRxiv : the preprint server for health sciences
2026

Temporal trends in heart rate characteristic index preceding necrotizing enterocolitis in preterm infants.

Journal of neonatal-perinatal medicine
2026

[Use of teduglutide in short bowel syndrome in infants, children and adolescents: Position paper of the working group "Chronic intestinal failure" of the Society for Paediatric Gastroenterology and Nutrition (GPGE)].

Zeitschrift fur Gastroenterologie
2026

Enteral feeding during cyclooxygenase inhibitor treatment for patent ductus arteriosus: A systematic review.

Pediatrics international : official journal of the Japan Pediatric Society
2026

Spontaneous duodenal perforation in a neonate: A case report.

Radiology case reports
2026

The RNA-binding protein Imp1 promotes a Spdef transcriptional program and mucus fucosylation during necrotizing enterocolitis.

bioRxiv : the preprint server for biology
2026

Incidence and outcome of major perinatal comorbidities of all hospitalized neonates requiring intensive and critical care: a livebirth population-based survey.

The journal of maternal-fetal &amp; neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
2026

The impact of the severity of placental insufficiency on rates of necrotizing enterocolitis in early-onset fetal growth restriction (reply to letter to the editor).

American journal of obstetrics and gynecology
2026

Apgar Score Plus Umbilical Artery pH and Adverse Neonatal Outcomes in Very Preterm Infants.

JAMA network open
2024

Necrotizing enterocolitis in a patient with Microvillous Inclusion Disease: A case report.

Intestinal Failure (New York, N.Y.)
2026

Cytomegalovirus-induced severe enterocolitis associated with ANCA-associated vasculitis and diffuse alveolar haemorrhage in a child: a diagnostic and therapeutic dilemma.

BMC pediatrics
2026

Time-dependent Amino Acid Crosstalk Shapes Macrophage Responses in Necrotizing Enterocolitis.

Cellular and molecular gastroenterology and hepatology
2026

First-in-human pilot study of broadband optical spectroscopy (BOS) as noninvasive surveillance for necrotizing enterocolitis (NEC).

Journal of pediatric surgery
2026

Navigating the United States FDA advisory: Probiotics in Preterm Infants.

Journal of perinatology : official journal of the California Perinatal Association
2026

Investigate the effects of donor breast milk and formula milk on metabolites in preterm infants through non-targeted metabolomics.

BMC nutrition
2026

Impact of different hemodynamic states of patent ductus arteriosus on cerebral, mesenteric, and renal perfusion in preterm infants: a doppler ultrasound analysis.

BMC pediatrics
2026

Short-chain fructooligosaccharides protect against intestinal injury in NEC by restoring AKT/GSK-3β signaling.

Journal of pediatric surgery
2026

Perinatal and Maternal Outcomes by Indication for Delivery in the Second Trimester.

American journal of perinatology
2025

Efficacy and safety of Kangaroo mother care vs. conventional care during hospitalization for preterm and/or low birth weight infants: a meta-analysis with trial sequential analysis of randomized controlled trials.

Frontiers in medicine
2025

m6A epigenetic signature in necrotizing enterocolitis: insights from murine to neonatal studies.

Frontiers in immunology
2026

The futile search for biomarkers for necrotizing enterocolitis.

Pediatric research
2026

Beyond survival: growth trajectories in necrotizing enterocolitis.

Pediatric research
2026

Osmolality of fortified human milk with contemporary human milk fortifiers.

Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
2025

The impact of AMniotic FluId on the development and microBIal colonization of the prEterm intestinal tract (AMFIBIE): study protocol for a multicenter prospective cohort study.

Frontiers in pediatrics
2025

Necrotising enterocolitis biomarkers: a systematic review.

Frontiers in pediatrics
2025

Partially hydrolyzed formula with high sn-2 palmitic acid on eosinophils and outcomes in preterm infants: PRIOR secondary analysis.

Frontiers in pharmacology
2026

Histopathologic and Genomic Characterization of a Novel Caprine Astrovirus Identified in a Boer Goat Kid in Illinois, United States.

Viruses
2026

Post-Surgical Gut Microbiota Alterations in Pediatric Patients with Intestinal Disorders.

Journal of clinical medicine
2025

Machine Learning-Based Prediction of Surgical Intervention in Preterm Infants with Necrotizing Enterocolitis: A Retrospective Cohort Study.

Children (Basel, Switzerland)
2026

Local Peritoneal Cytokine Response IL-1β, IL-6, TNF-α in a Standardized Neonatal Rat Model of Necrotizing Enterocolitis.

International journal of molecular sciences
2026

Neonatal Sepsis as Organ Dysfunction: Prognostic Accuracy and Clinical Utility of the nSOFA in the NICU-A Systematic Review.

Diagnostics (Basel, Switzerland)
2026

Identifying the risk factors of autism spectrum disorders in infants born preterm: a systematic review and meta-analysis.

European child &amp; adolescent psychiatry
2025

Complications of Interventional Versus Surgical Closure of Patent Ductus Arteriosus in Very Preterm Infants-A Retrospective Analysis.

Journal of cardiovascular development and disease
2026

Transfusion of blood products and neonatal outcomes in preterm infants: A retrospective cohort study.

Transfusion
2026

THE INAPRES (Indonesia Preeclampsia Study): impact of eclampsia on maternal and perinatal outcomes among women with preeclampsia: findings from a National Multicenter Cohort.

AJOG global reports
2026

Antibiofilm Activity of Phenyllactic Acid Against Cronobacter sakazakii Biofilms: Insights Into Food-Contact Surface and Membrane Integrity.

Journal of food science
2026

Therapeutic potential and translational challenges of extracellular vesicles in neonatal medicine.

Bioengineering &amp; translational medicine
2026

Molecular and Chromatin Accessibility Programs Underlying Epithelial Injury and Impaired Regeneration in Neonatal Necrotizing Enterocolitis.

Cellular and molecular gastroenterology and hepatology
2026

Patterns of Neonatal and Neurodevelopmental Comorbidities in Neonates of &lt;29 Weeks' Gestation.

Neonatology
2026

Effects of extensive protein hydrolysate in supporting intestinal barrier function in vitro.

Pediatric research
2026

Food and Drug Administration Expert Panel on Infant Formula "Operation Stork Speed" June 2025: Part 3, Marketing of Infant Formulas, Breastfeeding Support, Hypoallergenic Formulas, and Nutrition for Preterm Infants.

Advances in nutrition (Bethesda, Md.)
2026

Quantitative assessment of neonatal health using dried blood spot metabolite profiles and deep learning.

Science translational medicine
2025

Case Report: genotype-phenotype correlations in FLNA mutations: insights from a case of multisystem dysfunction.

Frontiers in genetics
2026

Risk for pediatric intensive care utilization in children born before 30 weeks of gestation: a single-center study.

European journal of pediatrics
2026

Identification of key mitochondria-related genes in necrotizing enterocolitis using single-cell hdWGCNA and experimental verification.

Pediatric research
2025

Overview of extracellular vesicles as biomarkers and therapeutic tools in pediatric diseases: focus on the gut-lung axis.

Extracellular vesicles and circulating nucleic acids
2025

Platelet-to-C-reactive protein ratio stratifies surgical risk and mortality in necrotizing enterocolitis neonates with portal venous gas.

Frontiers in pediatrics
2026

Surgical decision-making strategies in preterm neonates with necrotizing enterocolitis: A randomized controlled clinical trial.

Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica
2026

Necrotizing Enterocolitis and Shunt Survival in Premature Infants with Posthemorrhagic Hydrocephalus: A Hydrocephalus Clinical Research Network Study.

The Journal of pediatrics
2026

Intravenous Immunoglobulin Administration Induces Severe Anemia and Cross-Matching Incompatibility in Neonates.

Clinical laboratory
2026

Association of anemia and necrotizing enterocolitis in neonates: Systematic review and meta-analysis of transfusion thresholds, erythropoietin trials, and observational studies.

Journal of neonatal-perinatal medicine
2026

Deep learning feature-based model on abdominal radiography outperforms experts for early necrotizing enterocolitis diagnosis in neonates.

European radiology
2026

For infants with surgical necrotizing enterocolitis, does primary anastomosis or stoma formation provide shorter parenteral nutrition?

Journal of perinatology : official journal of the California Perinatal Association
2026

Perioperative Monitoring of Regional Oxygen Saturation in Congenital Heart Disease: Systematic Review of Literature up to 2023.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2025

Deciphering immune cell interaction aberrations in necrotizing enterocolitis: the regulatory role of DHRS7.

Frontiers in immunology
2026

Promoting Human Milk and Breastfeeding for the Very Low Birth Weight Infant: Clinical Report.

Pediatrics
2026

Resource utilization and surgical risk in pediatric pneumatosis intestinalis.

Journal of pediatric surgery
2026

Transcriptional stratification of necrotizing enterocolitis identifies distinct disease subtypes.

Scientific reports
2026

Nutritional management of neonates who undergo major surgery for gastrointestinal disorders: a joint position paper of the Italian Society of Neonatology (SIN), the Italian Society of Pediatric Surgery (SICP), and the Italian Society of Pediatric Nutrition (SINUPE).

Italian journal of pediatrics
2026

Deciphering the TLR4 and NLRP3 Inflammasome Crosstalk for Therapeutic Restoration of Intestinal and Systemic Immunity.

Digestive diseases and sciences
2026

ALAS2 Prevents Neonatal Necrotizing Enterocolitis by Improving Ferroptosis in Intestinal Epithelial Cells Through Inhibition of Oxidative Stress.

Mediators of inflammation
2026

Necrotizing enterocolitis following a single very low dose of octreotide in a patient with congenital hyperinsulinism: a case successfully managed with 18F-DOPA PET/CT-guided surgery.

Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology
2026

Disruption of bile acid homeostasis potentiates Paneth cell ablation by activating the intestinal Farnesoid X receptor in necrotizing enterocolitis.

NPJ biofilms and microbiomes
2026

General movements and neurodevelopmental outcomes at 2 years of age in infants born very preterm.

Developmental medicine and child neurology
2026

Sepsis Associated Necrotizing Enterocolitis (SA-NEC) in Preterm Infants: Risk Factors and Clinical Outcomes.

Indian journal of pediatrics
2026

Beneficial Effects and Factors Associated With Provision of Breast Milk at Neonatal Intensive Care Unit Discharge to Very Low Birth Weight Infants: A Nationwide Cohort Study in Korea.

Journal of Korean medical science
2026

Cluster-randomized evaluation of neonatal intensive care unit quality improvement interventions in extremely preterm infants: secondary analysis of the INTACT trial.

BMC pediatrics
2025

Anticoagulant Therapy in Neonatal Acute Infectious Peritonitis Based on the TAT, PIC, t-PAIC, and sTM: A New Case Series.

TH open : companion journal to thrombosis and haemostasis
2026

Prophylactic antibiotics to prevent postcesarean infection: which antimicrobial, when, how, and why?

American journal of obstetrics and gynecology
2025

Gut Microbiota and Short-Chain Fatty Acids in the Pathogenesis of Necrotizing Enterocolitis in Very Preterm Infants.

Acta naturae
2025

Succinate Promotes M1 Polarization of Intestinal Macrophages in Mice With Necrotizing Enterocolitis Through the PI3K/AKT Pathway.

Pediatric discovery
2026

Effect of Oral Colostrum Administration Duration on Clinical Outcomes in Preterm Infants: A Randomized Controlled Trial.

Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine
2025

L-cystine alleviates necrotizing enterocolitis by regulating ferroptosis and Th17 cell differentiation via the IL-6/STAT3 pathway.

Communications biology
2025

Longitudinal Fecal Short-Chain Fatty Acid Trajectories in Preterm Infants with Early-Onset Neonatal Sepsis: A Pilot Study.

Life (Basel, Switzerland)
2025

Proinflammatory state and metabolic dysregulation linking delayed feeding progression to extrauterine restricted head growth in extremely preterm infants.

BMC medicine
2025

Evaluating the Safety of Gastrointestinal Contrast Agents in Pediatric Patients: A Retrospective Study.

Cureus
2025

Bringing Imaging to the Bedside: The Growing Impact of Point-of-Care Ultrasound in Pediatric and Neonatal Intensive Care.

Cureus
2025

Impact of three mammalian milk-derived fortifiers on morbidity and mortality in preterm infants: a systematic review and network meta-analysis.

International breastfeeding journal
2025

Gut microbiota composition in preterm infants with and without necrotizing enterocolitis: a systematic review and narrative synthesis.

Access microbiology
2025

Golden hour(s) quality improvement protocols and their effect on outcomes in preterm infants ≤ 32 weeks of gestation: a scoping review.

BMC pediatrics
2026

Probiotic supplementation in very low birth weight infants: A single center experience in safety, tolerability, and necrotizing enterocolitis.

Journal of perinatology : official journal of the California Perinatal Association
2026

Lactiplantibacillus plantarum JY039 Ameliorates Necrotizing Enterocolitis via Intestinal Stem Cell Regeneration.

Journal of agricultural and food chemistry
2025

Remote ischemic conditioning in necrotizing enterocolitis: an extended phase I safety study.

Pediatric surgery international
2025

Interorgan Communication-Pulmonary Vein Stenosis in Children-A Review of Epidemiology, Pathophysiology, and Current Management Principles.

Comprehensive Physiology
2025

Impact of bronchopulmonary dysplasia, brain injury, necrotizing enterocolitis, retinopathy of prematurity and sepsis on neurodevelopmental outcomes in premature infants.

Journal of perinatology : official journal of the California Perinatal Association
2026

Experience with physiological based cord clamping is associated with increased effect size: a post-hoc analysis of the ABC3 trial.

Resuscitation
2026

Prediction of Language Development in Neonates Born at Less than 32 Weeks of Gestation.

The Journal of pediatrics
2025

Increase in Necrotizing Enterocolitis with Cessation of Bifidobacteriumlongum ssp. infantis Administration in Very Low Birthweight Infants: A Single Center Retrospective Cohort Study.

The Journal of pediatrics
2025

Necrotizing enterocolitis in a neonate with severe congenital pulmonary valve stenosis complicated by a postoperative right atrial thrombus: a case report.

Frontiers in pediatrics
2025

Gastroschisis: diagnosis, prognosis and treatment options.

Frontiers in pediatrics
2025

Development of a predictive model for severe adverse outcomes following surgery for neonatal necrotizing enterocolitis: a nomogram study based on postoperative intestinal failure beyond 42 days and death.

Frontiers in pediatrics
2025

Growth outcome trends after necrotizing enterocolitis in preterm infants across changes in nutritional practices.

Pediatric research
2025

Probiotics and the intestinal tight junction barrier function.

Frontiers in cell and developmental biology
2025

New biomarkers to predict the need for surgery of necrotizing enterocolitis: a study based on abdominal X-ray radiomics and machine learning.

Biomedical engineering online
2025

Inpatient morbidities and medical technology use at 2 years among extremely preterm infants.

Pediatric research
2025

Cardiorespiratory signatures of necrotizing enterocolitis: a 4-NICU study of very low birth weight infants.

Pediatric research
2025

[Efficacy and safety of ibuprofen for the treatment of patent ductus arteriosus in preterm infants of different postnatal ages].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
2026

[Consistency and risk factor analysis of 2 growth chart in the diagnosis of extrauterine growth restriction in preterm infants with a gestational age at birth of less than 32 weeks].

Zhonghua er ke za zhi = Chinese journal of pediatrics
2025

Comparisons of fecal microbiota and cytokines in preterm infants preceding necrotizing enterocolitis and feeding intolerance: An observational study.

Medicine
2025

SARS-CoV-2 infection during pregnancy and necrotizing enterocolitis: case report and review of the literature.

Italian journal of pediatrics
2025

Association of antenatal dexamethasone administration timing with outcomes in preterm infants in a low- and middle-income country.

Frontiers in medicine
2026

Neonatal Multimorbidity is a Poor Predictor of Health and Developmental Outcomes after Preterm Birth.

The Journal of pediatrics
2026

Association between Infant Birth Size Classification and Development of Morbidities in the Neonatal Intensive Care Unit: A Cohort Study.

Neonatology
2026

Whole-genome sequencing-based typing methods for Clostridium butyricum strains from clinical, animal, plant, and environmental sources.

Microbiology spectrum
2025

Elevated DUOX2 levels correlate with necrotizing enterocolitis development.

Frontiers in cellular and infection microbiology
2025

Efficacy of lung surfactant combined with budesonide in improving bronchopulmonary dysplasia and growth of very low birth weight infants.

Frontiers in pediatrics
2025

[Risk factors and prognosis of first extubation failure in neonates undergoing invasive mechanical ventilation].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
2025

The impact of early stoma closure on infants after surgery for necrotizing enterocolitis (NEC): real-world data analysis.

Updates in surgery
2025

Risk Factors Associated with Postnatal Growth Velocity in Preterm Infants in a Tertiary Hospital in Northeast Mexico.

Journal of clinical medicine
2025

Epidemiological Characteristics of Pediatric Patients with Intestinal Failure in Spain: Data from the REPAFI Registry.

Nutrients
2026

Necessity of enterostomy at the initial operation in neonatal intestinal perforation: A nationwide matched study in Japan.

Journal of pediatric surgery
2025

Distinguishing Intraventricular Hemorrhage From Infectious Etiologies in Febrile Late Preterm Neonates: Case Studies in Antibiotic Stewardship.

Cureus
2025

Elevated day-2 hemoglobin P₅₀ and risk of necrotizing enterocolitis in preterm infants: a pilot study.

Pediatric surgery international
2025

Low lymphozyte pool, colon perforation and hydrocephalus as clinical features in an infant with a postzygotic PIK3CA variant.

Frontiers in pediatrics
2025

The role of abdominal ultrasound in surgical decision making for necrotizing enterocolitis.

Journal of neonatal-perinatal medicine
2026

Interpretation of clinical variables in the use of artificial intelligence-based decision support for surgical necrotizing enterocolitis: A prospective study.

Journal of pediatric surgery
2026

Development of qPCR-PMAxx™ and ddPCR-PMAxx™ methods for quantitative detection of viable but not culturable Cronobacter sakazakii on stainless steel surfaces after desiccation and exposure to commercial disinfectant.

Food microbiology
2025

Eosinophil ETosis in severe non-IgE-mediated gastrointestinal food allergy, a neonatal necrotizing enterocolitis: A case report.

Asia Pacific allergy
2025

Outcomes of primary intestinal anastomosis versus stoma in necrotizing enterocolitis: A systematic review and meta-analysis.

Surgery in practice and science
2025

Neonatal blood transfusion practices in India: a nationwide survey of clinicians.

Frontiers in pediatrics
2025

Genetic disorders and associated morbidity, mortality, and congenital anomalies in preterm infants born at less than 34 weeks of gestation.

BMC pediatrics
2025

Gut microbiota in necrotizing enterocolitis: a bibliometric and visualization analysis.

Pediatric research
2025

Intraperitoneal rescue stem cell therapy in experimental NEC mitigates intestinal, pulmonary, and neuroinflammatory injury in mice.

Pediatric research
2026

Flash nano-encapsulation of probiotics: Bolstering environmental resistance and intestinal colonization to prevent necrotizing enterocolitis.

Journal of controlled release : official journal of the Controlled Release Society
2025

Rapid Isolation of Human Breast Milk-Derived Extracellular Vesicles.

Journal of visualized experiments : JoVE
2025

Hematocrit in the first 2 hours of life and short-term outcomes in very preterm infants: A secondary analysis from a prospective cohort study.

PloS one
2025

Flow-Driver-Generated Synchronized Nasal Intermittent Positive-Pressure Ventilation Versus Biphasic Positive Airway Pressure After Extubation in Preterm Infants.

Pediatric pulmonology
2026

The Glutamine Metabolic Switch Influences the Response of Neonatal Intestinal Macrophages to Breast Milk.

Cellular and molecular gastroenterology and hepatology
2025

Serum intestinal fatty acid binding protein is elevated during feeding advancement in necrotizing enterocolitis.

Pediatric research
2025

Does genetic susceptibility play a role in necrotizing enterocolitis?

Pediatric research
2025

IL-27Ra promotes the progression of neonatal necrotizing enterocolitis.

Scientific reports
2026

Prenatal exposure to air pollutants and neonatal necrotizing enterocolitis: Identifying critical gestational windows in Southern China.

Environmental research
2025

[Benefits and risks of antenatal corticosteroids].

Gynecologie, obstetrique, fertilite &amp; senologie
2025

L.Fermentum CECT5716 and B.Breve CECT7263 on premature infants morbidities: a randomized clinical trial.

Pediatric research
Ver todos os 4.363 no EuropePMC

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. CD177&#x207a; neutrophil-platelet aggregates contribute to thromboinflammation via NETs in necrotizing enterocolitis.
    Nature communications· 2026· PMID 41857007mais citado
  2. Impact of a Structured Brain Care Bundle on Severe Germinal Matrix Hemorrhage-Intraventricular Hemorrhage in Very Preterm Neonates: A Retrospective Cohort Study.
    Pediatric neurology· 2026· PMID 41855703mais citado
  3. Role of melatonin for prevention of necrotizing enterocolitis in preterm infants: a randomized controlled trial.
    Journal of tropical pediatrics· 2026· PMID 41847903mais citado
  4. Loss of polarity by Cdc42 depletion and oncogenic Kras activation in the mouse intestinal epithelia leads to a necrotizing enterocolitis (NEC)-like disease.
    Nature communications· 2026· PMID 41844631mais citado
  5. Clostridia from preterm infants metabolize human milk oligosaccharides to suppress pathobionts and modulate intestinal function in organoids.
    Nature microbiology· 2026· PMID 41840217mais citado
  6. Research progress on the role of bile acid metabolism in intestinal epithelial cell injury in necrotizing enterocolitis.
    Front Pediatr· 2026· PMID 41993903recente
  7. Emerging role of non-coding RNAs as biomarkers and therapeutic targets in preterm infants with necrotizing enterocolitis.
    Pediatr Res· 2026· PMID 41991624recente
  8. Antenatal Bartter Syndrome Type 4a: Ibuprofen Treatment for a Challenging Case of Very Low Birth Weight Infant.
    Pediatr Int· 2026· PMID 41988811recente
  9. When probiotics guidelines differ: a practical guide for clinicians and researchers.
    Gut Microbes· 2026· PMID 41986915recente
  10. Xanthan gum intake modifies the colon microbiota profile and causes mild colon inflammation in rats.
    PLoS One· 2026· PMID 41984887recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:391673(Orphanet)
  2. MONDO:0005313(MONDO)
  3. GARD:9767(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Artigo Wikipedia(Wikipedia)
  6. Q10859678(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Enterocolite necrotizante
Compêndio · Raras BR

Enterocolite necrotizante

ORPHA:391673 · MONDO:0005313
Prevalência
1-5 / 10 000
Herança
Not applicable
CID-10
P77 · Enterocolite necrotizante do feto e do recém-nascido
CID-11
Ensaios
27 ativos
Início
Neonatal
Prevalência
45.0 (Worldwide)
MedGen
UMLS
C0520459
Repurposing
8 candidatos
clidiniumacetylcholine receptor antagonist
hyoscyaminebacterial DNA inhibitor
hydrocortisone-phosphatephosphodiesterase inhibitor
+5 outros
EuropePMC
Wikidata
Wikipedia
Papers 10a
Evidência
🥉 Relato de caso
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