A enterocolite necrosante (ECN) é uma doença devastadora que afeta principalmente o intestino de bebês prematuros. A parede do intestino é invadida por bactérias, que causam infecção local e inflamação que pode destruir a parede do intestino (intestino). Essa destruição da parede intestinal pode levar à perfuração do intestino e ao derramamento de fezes no abdômen do bebê, o que pode resultar em uma infecção avassaladora e morte.
Introdução
O que você precisa saber de cara
A enterocolite necrosante (ECN) é uma doença devastadora que afeta principalmente o intestino de bebês prematuros. A parede do intestino é invadida por bactérias, que causam infecção local e inflamação que pode destruir a parede do intestino (intestino). Essa destruição da parede intestinal pode levar à perfuração do intestino e ao derramamento de fezes no abdômen do bebê, o que pode resultar em uma infecção avassaladora e morte.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Entender a doença
Do básico ao detalhe, leia no seu ritmo
Preparando trilha educativa...
Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 20 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 34 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Genética e causas
O que está alterado no DNA e como passa nas famílias
Nenhum gene associado encontrado
Os dados genéticos desta condição ainda estão sendo catalogados.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Enterocolite necrotizante
Selecione um estado ou use sua localização para ver resultados.
Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
🟢 Recrutando agora
11 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.
Outros ensaios clínicos
237 ensaios clínicos encontrados, 27 ativos.
Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 5.507
CD177⁺ neutrophil-platelet aggregates contribute to thromboinflammation via NETs in necrotizing enterocolitis.
Este estudo revela que a Enterocolite Necrosante (NEC) em prematuros é impulsionada por um processo de "tromboinflamação" intestinal, onde agregados específicos de neutrófilos CD177+ e plaquetas (NPAs) são os principais causadores de lesão. Os níveis elevados desses agregados (CD177+ NPAs) podem servir como importantes biomarcadores para diagnosticar e monitorizar a gravidade da doença. Adicionalmente, o tratamento com heparina de baixo peso molecular (LMWH) mostrou potencial para prevenir a formação desses agregados e reduzir a gravidade da NEC em modelos experimentais, apontando para novas estratégias de tratamento e prevenção.
🇧🇷 traduzidoImpact of a Structured Brain Care Bundle on Severe Germinal Matrix Hemorrhage-Intraventricular Hemorrhage in Very Preterm Neonates: A Retrospective Cohort Study.
Este estudo demonstrou que a implementação de um "Pacote de Cuidados Cerebrais" (BCB) estruturado em unidades neonatais para bebês muito prematuros reduziu significativamente a hemorragia intraventricular grave (GMH-IVH) – caindo de 15% para 5% – e também diminuiu acentuadamente a sepse de início tardio. Estes resultados são importantes para médicos e pais, pois sugerem que a adoção de BCBs é uma estratégia eficaz para proteger o desenvolvimento neurológico e a saúde geral de recém-nascidos vulneráveis.
🇧🇷 traduzidoRole of melatonin for prevention of necrotizing enterocolitis in preterm infants: a randomized controlled trial.
Este estudo demonstrou que a administração de melatonina por via oral pode reduzir significativamente a incidência de enterocolite necrosante (NEC) e a mortalidade em bebês prematuros com intolerância alimentar. A terapia também acelerou o alcance da alimentação enteral completa e diminuiu marcadores inflamatórios. Isso sugere que a melatonina é uma opção de tratamento prática, acessível e potencialmente vital para melhorar os desfechos desses pacientes.
🇧🇷 traduzidoLoss of polarity by Cdc42 depletion and oncogenic Kras activation in the mouse intestinal epithelia leads to a necrotizing enterocolitis (NEC)-like disease.
Este estudo em camundongos sugere que a perda da polaridade celular, combinada com a ativação do gene Kras oncogênico, pode ser uma causa fundamental para o desenvolvimento de uma doença semelhante à enterocolite necrosante (NEC), caracterizada por inflamação e morte celular grave no intestino. Mais importante para pacientes e médicos, a pesquisa identificou que a supressão de vias de sinalização específicas (como YAP, IL-1 e TNFα) ou da morte celular por necroptose conseguiu reverter essa patologia intestinal, abrindo portas para novas abordagens terapêuticas para a NEC.
🇧🇷 traduzidoClostridia from preterm infants metabolize human milk oligosaccharides to suppress pathobionts and modulate intestinal function in organoids.
Focando na proteção de bebês prematuros contra a enterocolite necrosante (ECN), este estudo revela que um tipo específico de bactéria, *Clostridium perfringens* (sem a toxina perfringolisina O), isolada de prematuros, também metaboliza os oligossacarídeos do leite humano (HMOs). Ao fazer isso, essas bactérias produzem metabólitos benéficos, promovem o crescimento de bactérias saudáveis e inibem patógenos, além de reduzir a inflamação intestinal. Isso sugere um novo e promissor mecanismo pelo qual certas cepas de *Clostridia* podem contribuir significativamente para proteger a saúde intestinal de bebês prematuros e prevenir a ECN.
🇧🇷 traduzidoPublicações recentes
Research progress on the role of bile acid metabolism in intestinal epithelial cell injury in necrotizing enterocolitis.
Emerging role of non-coding RNAs as biomarkers and therapeutic targets in preterm infants with necrotizing enterocolitis.
🥉 Relato de casoAntenatal Bartter Syndrome Type 4a: Ibuprofen Treatment for a Challenging Case of Very Low Birth Weight Infant.
When probiotics guidelines differ: a practical guide for clinicians and researchers.
Xanthan gum intake modifies the colon microbiota profile and causes mild colon inflammation in rats.
📚 EuropePMC4.363 artigos no totalmostrando 198
Rethinking probiotic delivery: new hope for preventing necrotizing enterocolitis.
Expert opinion on drug deliveryTrends in Survival and Short-Term Outcomes Among Preterm Infants Less Than 32 Weeks From 2016 to 2022: A Retrospective Cohort Study at a Tertiary Medical Center in the UAE.
CureusCD177⁺ neutrophil-platelet aggregates contribute to thromboinflammation via NETs in necrotizing enterocolitis.
Nature communicationsImpact of a Structured Brain Care Bundle on Severe Germinal Matrix Hemorrhage-Intraventricular Hemorrhage in Very Preterm Neonates: A Retrospective Cohort Study.
Pediatric neurologyPredicting the Risk of Reoperative Intervention for Adhesive Bowel Obstruction in Neonates: The Neonatal Adhesion Risk Score (NARS).
Journal of pediatric surgeryThe role of mesencephalic astrocyte-derived neurotrophic factor in digestive diseases.
Annals of medicineRole of melatonin for prevention of necrotizing enterocolitis in preterm infants: a randomized controlled trial.
Journal of tropical pediatricsLoss of polarity by Cdc42 depletion and oncogenic Kras activation in the mouse intestinal epithelia leads to a necrotizing enterocolitis (NEC)-like disease.
Nature communicationsClostridia from preterm infants metabolize human milk oligosaccharides to suppress pathobionts and modulate intestinal function in organoids.
Nature microbiologyThe role of myeloid cells in the pathogenesis of necrotizing enterocolitis; a scoping review.
Frontiers in pediatricsShort Antibiotic Treatment for Coagulase-negative Staphylococcal Sepsis in Premature Infants: A Multicenter Noninferiority Study.
The Pediatric infectious disease journalAmino acid-based formula and feeding outcomes in preterm infants with recurrent intolerance: A propensity score-matched study.
Nutrition (Burbank, Los Angeles County, Calif.)A Novel Rapid 3D Tissue-Clearing and Staining Approach for Enteric Neurovascular Imaging and Pathology Applications.
Diagnostics (Basel, Switzerland)Identification of the expression of tRNA-derived small RNAs associated with necrotizing enterocolitis.
Pediatric researchImproving preoperative enteral feeding for newborns with congenital heart disease.
Journal of perinatology : official journal of the California Perinatal AssociationAssociation between risk-adjusted mortality and severe morbidity in very low birth weight infants: a multicenter study from the NEOCOSUR network.
Journal of perinatology : official journal of the California Perinatal AssociationThe impact of Assisted Reproductive Technology on the neonatal prognosis of newborns < 29 weeks gestational age: a retrospective case-control study.
Journal of gynecology obstetrics and human reproductionSingle-center experience with pediatric short bowel syndrome: clinical outcomes based on etiology and anatomical type in a retrospective cohort study.
Annals of surgical treatment and researchApplications of artificial intelligence in pediatric general surgery: a systematic review.
Translational pediatricsRisk factors and prevalence of retinopathy of prematurity in very low birth weight preterm infants: a systematic review and meta-analysis.
Translational pediatricsA Prospective-Retrospective Observational Cohort Study of Short-Term Health Outcomes of Preterm Very Low Birth Weight Infants Receiving Oropharyngeal Administration of Own Mother's Colostrum.
Current therapeutic research, clinical and experimentalEarly Diagnosis of Atypical Necrotizing Enterocolitis in Preterm Infants Using Point-of-Care Liver Ultrasound for Portal Venous Gas.
Journal of clinical ultrasound : JCUMesenchymal stromal cell therapy restores intestinal integrity and attentuates inflammation in a preterm piglet model of necrotizing enterocolitis.
Pediatric surgery internationalHigh-Frequency Oscillation vs Mechanical Ventilation for Neonatal Acute Respiratory Distress Syndrome: A Randomized Clinical Trial.
JAMA network openPrevalence, perinatal risk factors and clinical outcomes of respiratory Ureaplasma species colonization in hospitalized preterm infants.
Frontiers in pediatricsThe role of bovine colostrum in feeding intolerance in preterm neonates: a systematic review and meta-analysis of randomized controlled trials.
Frontiers in nutritionFortification of human milk for feeding preterm infants: What is the ideal strategy?
Seminars in fetal & neonatal medicineDeficiency of interleukin-40 prevents intestinal damage in experimental necrotizing enterocolitis by inhibiting NETosis.
Cell communication and signaling : CCSClinical exposure thresholds associated with retinopathy of prematurity in preterm infants born at high altitude.
Respiratory physiology & neurobiologyNegative pressure wound therapy (NPWT) in the open abdomen in a preterm newborn with necrotizing enterocolitis: case report.
Italian journal of pediatricsDecrease in healthcare-associated infection rates in preterm infants-longitudinal data from 15 years of nationwide surveillance in Germany.
Infection control and hospital epidemiologyEvaluation of the prognostic nutritional index in preterm infants: A retrospective study examining its relationship with retinopathy of prematurity and clinical risk factors.
Journal of neonatal-perinatal medicineNecrotizing Enterocolitis in Term Neonates: A Retrospective Chart Review from Children's Medical Center, Tehran (2020-2023).
Archives of Iranian medicineSepsis in neonates with necrotizing enterocolitis: outcomes and predictive model.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical MicrobiologyThe high-risk minority: undetected preterm SGA disproportionately contributes to adverse outcomes in a Chinese cohort.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal ObstetriciansImpact of feeding strategies during red blood cell transfusion on cerebral and splanchnic oxygenation in preterm infants: Randomized pilot study.
Journal of neonatal-perinatal medicineImpact of timing from last dose of dexamethasone administration to delivery, different steroid courses, and fetal number on preterm neonatal outcomes.
PloS onePlanned mode of delivery and neonatal outcomes in pregnancies complicated by late-onset fetal growth restriction: a retrospective cohort study.
Archives of gynecology and obstetricsNeonatal Mortality in Low-Birth-Weight Infants in Southern Ethiopia: A Multicenter Cohort Study With Multilevel Analysis.
Sage open pediatrics[Clinical significance of neutrophil chemokines in intestinal tissue and related receptor expression in peripheral blood in neonatal necrotizing enterocolitis].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics[Ultrasound diagnosis of necrotizing enterocolitis in neonates].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatricsDoes Necrotizing Enterocolitis Severity and Timing, Rather than Necrotizing Enterocolitis Itself, Drive Shunt Failure in Premature Infants with Posthemorrhagic Hydrocephalus?
The Journal of pediatricsEarly lung ultrasound score combined with umbilical cord-blood procalcitonin improves 1-year prognostic stratification in preterm neonates with respiratory distress syndrome.
Frontiers in pediatricsThe Angel in the Marble: Antibiotic Duration in the Neonatal Intensive Care Unit.
Antibiotics (Basel, Switzerland)Hematologic Inflammatory Indices Predict Mortality in Surgical Necrotizing Enterocolitis Among Premature Infants.
Children (Basel, Switzerland)NEC-Associated Bronchopulmonary Dysplasia and the Gut-Lung Axis in Preterm Infants.
American journal of perinatologyThe Role of APOL1 in Necrotizing Enterocolitis and Its Promise as a Diagnostic Biomarker.
Mediators of inflammationNEC-Net: A hybrid transformer for necrotizing enterocolitis diagnosis by lesion segmentation on abdominal X-rays.
Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging SocietyBalancing therapeutic benefits and hidden risks of proton pump inhibitors in pediatric practice: a narrative review and update.
Clinical and experimental pediatricsTranscriptome, metabolome, and inflammatory and oxidative properties of Clostridium butyricum CB1002 clinical strain and its isogenic mutant Δhbd.
Applied and environmental microbiologyRisk factors of necrotizing enterocolitis in very low birth weight infants: a meta-analysis.
Frontiers in pediatricsAngiogenic factors and fetal Doppler for predicting adverse pregnancy outcome in early-onset small fetuses with and without pre-eclampsia.
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and GynecologyLive biotherapeutic product IBP-9414 (L. reuteri) in very low birth weight infants: the Connection Study.
Pediatric researchMethodological framework for the surveillance of healthcare-associated infections in high-risk infants: the NeoIPC surveillance core module protocol.
Antimicrobial resistance and infection controlNecrotizing Enterocolitis in Preterm Infants: An Inflammatory Condition at the Crossroads of Intestinal Immaturity, Dysbiosis, and Nutrition.
International journal of pediatricsOutcomes and complications of invasive versus non-invasive respiratory support in extremely preterm infants: a retrospective study.
BMC pediatricsAssociation between initial empirical antibiotic therapy and necrotizing enterocolitis in very preterm infants at different risk for early-onset sepsis: a multicenter cohort study.
BMC pregnancy and childbirthACR Appropriateness Criteria® Abdominal Pain-Child.
Journal of the American College of Radiology : JACRSurgical site infections in neonates: A contemporary review.
Seminars in pediatric surgeryBiomarkers for feeding intolerance in infants with complex heart defects undergoing palliation surgery.
Journal of pediatric gastroenterology and nutritionNeonatal Sepsis from 2014 to 2024: The Resurgence of Gram-Negative Rods.
The Journal of pediatricsEffects of specialized proresolving mediators on gut epithelial barrier in early life.
The Journal of pharmacology and experimental therapeuticsAutomatic versus manual control of oxygen and neonatal clinical outcomes in extremely preterm infants: a multicentre, parallel-group, randomised, controlled, superiority trial.
The Lancet. Child & adolescent healthEffectiveness of Ibuprofen Arginine, Ibuprofen Lysine, and Indomethacin for Patent Ductus Arteriosus Closure in Neonates.
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAGRapid Detection of Inter-alpha Inhibitor Proteins in Neonatal Sepsis and Necrotizing Enterocolitis.
medRxiv : the preprint server for health sciencesTemporal trends in heart rate characteristic index preceding necrotizing enterocolitis in preterm infants.
Journal of neonatal-perinatal medicine[Use of teduglutide in short bowel syndrome in infants, children and adolescents: Position paper of the working group "Chronic intestinal failure" of the Society for Paediatric Gastroenterology and Nutrition (GPGE)].
Zeitschrift fur GastroenterologieEnteral feeding during cyclooxygenase inhibitor treatment for patent ductus arteriosus: A systematic review.
Pediatrics international : official journal of the Japan Pediatric SocietySpontaneous duodenal perforation in a neonate: A case report.
Radiology case reportsThe RNA-binding protein Imp1 promotes a Spdef transcriptional program and mucus fucosylation during necrotizing enterocolitis.
bioRxiv : the preprint server for biologyIncidence and outcome of major perinatal comorbidities of all hospitalized neonates requiring intensive and critical care: a livebirth population-based survey.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal ObstetriciansThe impact of the severity of placental insufficiency on rates of necrotizing enterocolitis in early-onset fetal growth restriction (reply to letter to the editor).
American journal of obstetrics and gynecologyApgar Score Plus Umbilical Artery pH and Adverse Neonatal Outcomes in Very Preterm Infants.
JAMA network openNecrotizing enterocolitis in a patient with Microvillous Inclusion Disease: A case report.
Intestinal Failure (New York, N.Y.)Cytomegalovirus-induced severe enterocolitis associated with ANCA-associated vasculitis and diffuse alveolar haemorrhage in a child: a diagnostic and therapeutic dilemma.
BMC pediatricsTime-dependent Amino Acid Crosstalk Shapes Macrophage Responses in Necrotizing Enterocolitis.
Cellular and molecular gastroenterology and hepatologyFirst-in-human pilot study of broadband optical spectroscopy (BOS) as noninvasive surveillance for necrotizing enterocolitis (NEC).
Journal of pediatric surgeryNavigating the United States FDA advisory: Probiotics in Preterm Infants.
Journal of perinatology : official journal of the California Perinatal AssociationInvestigate the effects of donor breast milk and formula milk on metabolites in preterm infants through non-targeted metabolomics.
BMC nutritionImpact of different hemodynamic states of patent ductus arteriosus on cerebral, mesenteric, and renal perfusion in preterm infants: a doppler ultrasound analysis.
BMC pediatricsShort-chain fructooligosaccharides protect against intestinal injury in NEC by restoring AKT/GSK-3β signaling.
Journal of pediatric surgeryPerinatal and Maternal Outcomes by Indication for Delivery in the Second Trimester.
American journal of perinatologyEfficacy and safety of Kangaroo mother care vs. conventional care during hospitalization for preterm and/or low birth weight infants: a meta-analysis with trial sequential analysis of randomized controlled trials.
Frontiers in medicinem6A epigenetic signature in necrotizing enterocolitis: insights from murine to neonatal studies.
Frontiers in immunologyThe futile search for biomarkers for necrotizing enterocolitis.
Pediatric researchBeyond survival: growth trajectories in necrotizing enterocolitis.
Pediatric researchOsmolality of fortified human milk with contemporary human milk fortifiers.
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral NutritionThe impact of AMniotic FluId on the development and microBIal colonization of the prEterm intestinal tract (AMFIBIE): study protocol for a multicenter prospective cohort study.
Frontiers in pediatricsNecrotising enterocolitis biomarkers: a systematic review.
Frontiers in pediatricsPartially hydrolyzed formula with high sn-2 palmitic acid on eosinophils and outcomes in preterm infants: PRIOR secondary analysis.
Frontiers in pharmacologyHistopathologic and Genomic Characterization of a Novel Caprine Astrovirus Identified in a Boer Goat Kid in Illinois, United States.
VirusesPost-Surgical Gut Microbiota Alterations in Pediatric Patients with Intestinal Disorders.
Journal of clinical medicineMachine Learning-Based Prediction of Surgical Intervention in Preterm Infants with Necrotizing Enterocolitis: A Retrospective Cohort Study.
Children (Basel, Switzerland)Local Peritoneal Cytokine Response IL-1β, IL-6, TNF-α in a Standardized Neonatal Rat Model of Necrotizing Enterocolitis.
International journal of molecular sciencesNeonatal Sepsis as Organ Dysfunction: Prognostic Accuracy and Clinical Utility of the nSOFA in the NICU-A Systematic Review.
Diagnostics (Basel, Switzerland)Identifying the risk factors of autism spectrum disorders in infants born preterm: a systematic review and meta-analysis.
European child & adolescent psychiatryComplications of Interventional Versus Surgical Closure of Patent Ductus Arteriosus in Very Preterm Infants-A Retrospective Analysis.
Journal of cardiovascular development and diseaseTransfusion of blood products and neonatal outcomes in preterm infants: A retrospective cohort study.
TransfusionTHE INAPRES (Indonesia Preeclampsia Study): impact of eclampsia on maternal and perinatal outcomes among women with preeclampsia: findings from a National Multicenter Cohort.
AJOG global reportsAntibiofilm Activity of Phenyllactic Acid Against Cronobacter sakazakii Biofilms: Insights Into Food-Contact Surface and Membrane Integrity.
Journal of food scienceTherapeutic potential and translational challenges of extracellular vesicles in neonatal medicine.
Bioengineering & translational medicineMolecular and Chromatin Accessibility Programs Underlying Epithelial Injury and Impaired Regeneration in Neonatal Necrotizing Enterocolitis.
Cellular and molecular gastroenterology and hepatologyPatterns of Neonatal and Neurodevelopmental Comorbidities in Neonates of <29 Weeks' Gestation.
NeonatologyEffects of extensive protein hydrolysate in supporting intestinal barrier function in vitro.
Pediatric researchFood and Drug Administration Expert Panel on Infant Formula "Operation Stork Speed" June 2025: Part 3, Marketing of Infant Formulas, Breastfeeding Support, Hypoallergenic Formulas, and Nutrition for Preterm Infants.
Advances in nutrition (Bethesda, Md.)Quantitative assessment of neonatal health using dried blood spot metabolite profiles and deep learning.
Science translational medicineCase Report: genotype-phenotype correlations in FLNA mutations: insights from a case of multisystem dysfunction.
Frontiers in geneticsRisk for pediatric intensive care utilization in children born before 30 weeks of gestation: a single-center study.
European journal of pediatricsIdentification of key mitochondria-related genes in necrotizing enterocolitis using single-cell hdWGCNA and experimental verification.
Pediatric researchOverview of extracellular vesicles as biomarkers and therapeutic tools in pediatric diseases: focus on the gut-lung axis.
Extracellular vesicles and circulating nucleic acidsPlatelet-to-C-reactive protein ratio stratifies surgical risk and mortality in necrotizing enterocolitis neonates with portal venous gas.
Frontiers in pediatricsSurgical decision-making strategies in preterm neonates with necrotizing enterocolitis: A randomized controlled clinical trial.
Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia PediatricaNecrotizing Enterocolitis and Shunt Survival in Premature Infants with Posthemorrhagic Hydrocephalus: A Hydrocephalus Clinical Research Network Study.
The Journal of pediatricsIntravenous Immunoglobulin Administration Induces Severe Anemia and Cross-Matching Incompatibility in Neonates.
Clinical laboratoryAssociation of anemia and necrotizing enterocolitis in neonates: Systematic review and meta-analysis of transfusion thresholds, erythropoietin trials, and observational studies.
Journal of neonatal-perinatal medicineDeep learning feature-based model on abdominal radiography outperforms experts for early necrotizing enterocolitis diagnosis in neonates.
European radiologyFor infants with surgical necrotizing enterocolitis, does primary anastomosis or stoma formation provide shorter parenteral nutrition?
Journal of perinatology : official journal of the California Perinatal AssociationPerioperative Monitoring of Regional Oxygen Saturation in Congenital Heart Disease: Systematic Review of Literature up to 2023.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care SocietiesDeciphering immune cell interaction aberrations in necrotizing enterocolitis: the regulatory role of DHRS7.
Frontiers in immunologyPromoting Human Milk and Breastfeeding for the Very Low Birth Weight Infant: Clinical Report.
PediatricsResource utilization and surgical risk in pediatric pneumatosis intestinalis.
Journal of pediatric surgeryTranscriptional stratification of necrotizing enterocolitis identifies distinct disease subtypes.
Scientific reportsNutritional management of neonates who undergo major surgery for gastrointestinal disorders: a joint position paper of the Italian Society of Neonatology (SIN), the Italian Society of Pediatric Surgery (SICP), and the Italian Society of Pediatric Nutrition (SINUPE).
Italian journal of pediatricsDeciphering the TLR4 and NLRP3 Inflammasome Crosstalk for Therapeutic Restoration of Intestinal and Systemic Immunity.
Digestive diseases and sciencesALAS2 Prevents Neonatal Necrotizing Enterocolitis by Improving Ferroptosis in Intestinal Epithelial Cells Through Inhibition of Oxidative Stress.
Mediators of inflammationNecrotizing enterocolitis following a single very low dose of octreotide in a patient with congenital hyperinsulinism: a case successfully managed with 18F-DOPA PET/CT-guided surgery.
Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric EndocrinologyDisruption of bile acid homeostasis potentiates Paneth cell ablation by activating the intestinal Farnesoid X receptor in necrotizing enterocolitis.
NPJ biofilms and microbiomesGeneral movements and neurodevelopmental outcomes at 2 years of age in infants born very preterm.
Developmental medicine and child neurologySepsis Associated Necrotizing Enterocolitis (SA-NEC) in Preterm Infants: Risk Factors and Clinical Outcomes.
Indian journal of pediatricsBeneficial Effects and Factors Associated With Provision of Breast Milk at Neonatal Intensive Care Unit Discharge to Very Low Birth Weight Infants: A Nationwide Cohort Study in Korea.
Journal of Korean medical scienceCluster-randomized evaluation of neonatal intensive care unit quality improvement interventions in extremely preterm infants: secondary analysis of the INTACT trial.
BMC pediatricsAnticoagulant Therapy in Neonatal Acute Infectious Peritonitis Based on the TAT, PIC, t-PAIC, and sTM: A New Case Series.
TH open : companion journal to thrombosis and haemostasisProphylactic antibiotics to prevent postcesarean infection: which antimicrobial, when, how, and why?
American journal of obstetrics and gynecologyGut Microbiota and Short-Chain Fatty Acids in the Pathogenesis of Necrotizing Enterocolitis in Very Preterm Infants.
Acta naturaeSuccinate Promotes M1 Polarization of Intestinal Macrophages in Mice With Necrotizing Enterocolitis Through the PI3K/AKT Pathway.
Pediatric discoveryEffect of Oral Colostrum Administration Duration on Clinical Outcomes in Preterm Infants: A Randomized Controlled Trial.
Breastfeeding medicine : the official journal of the Academy of Breastfeeding MedicineL-cystine alleviates necrotizing enterocolitis by regulating ferroptosis and Th17 cell differentiation via the IL-6/STAT3 pathway.
Communications biologyLongitudinal Fecal Short-Chain Fatty Acid Trajectories in Preterm Infants with Early-Onset Neonatal Sepsis: A Pilot Study.
Life (Basel, Switzerland)Proinflammatory state and metabolic dysregulation linking delayed feeding progression to extrauterine restricted head growth in extremely preterm infants.
BMC medicineEvaluating the Safety of Gastrointestinal Contrast Agents in Pediatric Patients: A Retrospective Study.
CureusBringing Imaging to the Bedside: The Growing Impact of Point-of-Care Ultrasound in Pediatric and Neonatal Intensive Care.
CureusImpact of three mammalian milk-derived fortifiers on morbidity and mortality in preterm infants: a systematic review and network meta-analysis.
International breastfeeding journalGut microbiota composition in preterm infants with and without necrotizing enterocolitis: a systematic review and narrative synthesis.
Access microbiologyGolden hour(s) quality improvement protocols and their effect on outcomes in preterm infants ≤ 32 weeks of gestation: a scoping review.
BMC pediatricsProbiotic supplementation in very low birth weight infants: A single center experience in safety, tolerability, and necrotizing enterocolitis.
Journal of perinatology : official journal of the California Perinatal AssociationLactiplantibacillus plantarum JY039 Ameliorates Necrotizing Enterocolitis via Intestinal Stem Cell Regeneration.
Journal of agricultural and food chemistryRemote ischemic conditioning in necrotizing enterocolitis: an extended phase I safety study.
Pediatric surgery internationalInterorgan Communication-Pulmonary Vein Stenosis in Children-A Review of Epidemiology, Pathophysiology, and Current Management Principles.
Comprehensive PhysiologyImpact of bronchopulmonary dysplasia, brain injury, necrotizing enterocolitis, retinopathy of prematurity and sepsis on neurodevelopmental outcomes in premature infants.
Journal of perinatology : official journal of the California Perinatal AssociationExperience with physiological based cord clamping is associated with increased effect size: a post-hoc analysis of the ABC3 trial.
ResuscitationPrediction of Language Development in Neonates Born at Less than 32 Weeks of Gestation.
The Journal of pediatricsIncrease in Necrotizing Enterocolitis with Cessation of Bifidobacteriumlongum ssp. infantis Administration in Very Low Birthweight Infants: A Single Center Retrospective Cohort Study.
The Journal of pediatricsNecrotizing enterocolitis in a neonate with severe congenital pulmonary valve stenosis complicated by a postoperative right atrial thrombus: a case report.
Frontiers in pediatricsGastroschisis: diagnosis, prognosis and treatment options.
Frontiers in pediatricsDevelopment of a predictive model for severe adverse outcomes following surgery for neonatal necrotizing enterocolitis: a nomogram study based on postoperative intestinal failure beyond 42 days and death.
Frontiers in pediatricsGrowth outcome trends after necrotizing enterocolitis in preterm infants across changes in nutritional practices.
Pediatric researchProbiotics and the intestinal tight junction barrier function.
Frontiers in cell and developmental biologyNew biomarkers to predict the need for surgery of necrotizing enterocolitis: a study based on abdominal X-ray radiomics and machine learning.
Biomedical engineering onlineInpatient morbidities and medical technology use at 2 years among extremely preterm infants.
Pediatric researchCardiorespiratory signatures of necrotizing enterocolitis: a 4-NICU study of very low birth weight infants.
Pediatric research[Efficacy and safety of ibuprofen for the treatment of patent ductus arteriosus in preterm infants of different postnatal ages].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics[Consistency and risk factor analysis of 2 growth chart in the diagnosis of extrauterine growth restriction in preterm infants with a gestational age at birth of less than 32 weeks].
Zhonghua er ke za zhi = Chinese journal of pediatricsComparisons of fecal microbiota and cytokines in preterm infants preceding necrotizing enterocolitis and feeding intolerance: An observational study.
MedicineSARS-CoV-2 infection during pregnancy and necrotizing enterocolitis: case report and review of the literature.
Italian journal of pediatricsAssociation of antenatal dexamethasone administration timing with outcomes in preterm infants in a low- and middle-income country.
Frontiers in medicineNeonatal Multimorbidity is a Poor Predictor of Health and Developmental Outcomes after Preterm Birth.
The Journal of pediatricsAssociation between Infant Birth Size Classification and Development of Morbidities in the Neonatal Intensive Care Unit: A Cohort Study.
NeonatologyWhole-genome sequencing-based typing methods for Clostridium butyricum strains from clinical, animal, plant, and environmental sources.
Microbiology spectrumElevated DUOX2 levels correlate with necrotizing enterocolitis development.
Frontiers in cellular and infection microbiologyEfficacy of lung surfactant combined with budesonide in improving bronchopulmonary dysplasia and growth of very low birth weight infants.
Frontiers in pediatrics[Risk factors and prognosis of first extubation failure in neonates undergoing invasive mechanical ventilation].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciencesThe impact of early stoma closure on infants after surgery for necrotizing enterocolitis (NEC): real-world data analysis.
Updates in surgeryRisk Factors Associated with Postnatal Growth Velocity in Preterm Infants in a Tertiary Hospital in Northeast Mexico.
Journal of clinical medicineEpidemiological Characteristics of Pediatric Patients with Intestinal Failure in Spain: Data from the REPAFI Registry.
NutrientsNecessity of enterostomy at the initial operation in neonatal intestinal perforation: A nationwide matched study in Japan.
Journal of pediatric surgeryDistinguishing Intraventricular Hemorrhage From Infectious Etiologies in Febrile Late Preterm Neonates: Case Studies in Antibiotic Stewardship.
CureusElevated day-2 hemoglobin P₅₀ and risk of necrotizing enterocolitis in preterm infants: a pilot study.
Pediatric surgery internationalLow lymphozyte pool, colon perforation and hydrocephalus as clinical features in an infant with a postzygotic PIK3CA variant.
Frontiers in pediatricsThe role of abdominal ultrasound in surgical decision making for necrotizing enterocolitis.
Journal of neonatal-perinatal medicineInterpretation of clinical variables in the use of artificial intelligence-based decision support for surgical necrotizing enterocolitis: A prospective study.
Journal of pediatric surgeryDevelopment of qPCR-PMAxx™ and ddPCR-PMAxx™ methods for quantitative detection of viable but not culturable Cronobacter sakazakii on stainless steel surfaces after desiccation and exposure to commercial disinfectant.
Food microbiologyEosinophil ETosis in severe non-IgE-mediated gastrointestinal food allergy, a neonatal necrotizing enterocolitis: A case report.
Asia Pacific allergyOutcomes of primary intestinal anastomosis versus stoma in necrotizing enterocolitis: A systematic review and meta-analysis.
Surgery in practice and scienceNeonatal blood transfusion practices in India: a nationwide survey of clinicians.
Frontiers in pediatricsGenetic disorders and associated morbidity, mortality, and congenital anomalies in preterm infants born at less than 34 weeks of gestation.
BMC pediatricsGut microbiota in necrotizing enterocolitis: a bibliometric and visualization analysis.
Pediatric researchIntraperitoneal rescue stem cell therapy in experimental NEC mitigates intestinal, pulmonary, and neuroinflammatory injury in mice.
Pediatric researchFlash nano-encapsulation of probiotics: Bolstering environmental resistance and intestinal colonization to prevent necrotizing enterocolitis.
Journal of controlled release : official journal of the Controlled Release SocietyRapid Isolation of Human Breast Milk-Derived Extracellular Vesicles.
Journal of visualized experiments : JoVEHematocrit in the first 2 hours of life and short-term outcomes in very preterm infants: A secondary analysis from a prospective cohort study.
PloS oneFlow-Driver-Generated Synchronized Nasal Intermittent Positive-Pressure Ventilation Versus Biphasic Positive Airway Pressure After Extubation in Preterm Infants.
Pediatric pulmonologyThe Glutamine Metabolic Switch Influences the Response of Neonatal Intestinal Macrophages to Breast Milk.
Cellular and molecular gastroenterology and hepatologySerum intestinal fatty acid binding protein is elevated during feeding advancement in necrotizing enterocolitis.
Pediatric researchDoes genetic susceptibility play a role in necrotizing enterocolitis?
Pediatric researchIL-27Ra promotes the progression of neonatal necrotizing enterocolitis.
Scientific reportsPrenatal exposure to air pollutants and neonatal necrotizing enterocolitis: Identifying critical gestational windows in Southern China.
Environmental research[Benefits and risks of antenatal corticosteroids].
Gynecologie, obstetrique, fertilite & senologieL.Fermentum CECT5716 and B.Breve CECT7263 on premature infants morbidities: a randomized clinical trial.
Pediatric researchAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
Ainda não temos associações cadastradas para Enterocolite necrotizante.
É de uma associação que acompanha esta doença? Fale com a gente →
Comunidades
Grupos ativos de quem convive com esta doença aqui no Raras
Ainda não existe comunidade no Raras para Enterocolite necrotizante
Pacientes, familiares e cuidadores se organizam em comunidades pra compartilhar experiências, fazer perguntas e se apoiar. Você pode ser o primeiro.
Tire suas dúvidas
Perguntas, dicas e experiências compartilhadas aqui na página
Participe da discussão
Faça login para postar dúvidas, compartilhar experiências e interagir com especialistas.
Fazer loginDoenças relacionadas
Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico
Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- CD177⁺ neutrophil-platelet aggregates contribute to thromboinflammation via NETs in necrotizing enterocolitis.
- Impact of a Structured Brain Care Bundle on Severe Germinal Matrix Hemorrhage-Intraventricular Hemorrhage in Very Preterm Neonates: A Retrospective Cohort Study.
- Role of melatonin for prevention of necrotizing enterocolitis in preterm infants: a randomized controlled trial.
- Loss of polarity by Cdc42 depletion and oncogenic Kras activation in the mouse intestinal epithelia leads to a necrotizing enterocolitis (NEC)-like disease.
- Clostridia from preterm infants metabolize human milk oligosaccharides to suppress pathobionts and modulate intestinal function in organoids.
- Research progress on the role of bile acid metabolism in intestinal epithelial cell injury in necrotizing enterocolitis.
- Emerging role of non-coding RNAs as biomarkers and therapeutic targets in preterm infants with necrotizing enterocolitis.
- Antenatal Bartter Syndrome Type 4a: Ibuprofen Treatment for a Challenging Case of Very Low Birth Weight Infant.
- When probiotics guidelines differ: a practical guide for clinicians and researchers.
- Xanthan gum intake modifies the colon microbiota profile and causes mild colon inflammation in rats.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:391673(Orphanet)
- MONDO:0005313(MONDO)
- GARD:9767(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
- Q10859678(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
