Raras
Buscar doenças, sintomas, genes...
Síndrome pediátrica de dificuldade respiratória aguda
ORPHA:685082CID-11 · CB00DOENÇA RARA

Síndrome do Desconforto Respiratório Agudo (SDRA) que ocorre em crianças e inclui a presença de novas manchas (visíveis em exames, como raio-x, em um ou ambos os pulmões) que indicam uma doença aguda do tecido pulmonar. Há também acúmulo de líquido nos pulmões (edema) que não pode ser totalmente explicado por excesso de fluidos no corpo ou por problemas no coração. Essa síndrome pode aparecer como uma nova doença pulmonar aguda em crianças que já possuem doenças pulmonares crônicas e/ou doenças cardíacas. Doenças pulmonares que surgem no período próximo ao nascimento (perinatal) são excluídas.

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Introdução

O que você precisa saber de cara

📋

Síndrome do Desconforto Respiratório Agudo (SDRA) que ocorre em crianças e inclui a presença de novas manchas (visíveis em exames, como raio-x, em um ou ambos os pulmões) que indicam uma doença aguda do tecido pulmonar. Há também acúmulo de líquido nos pulmões (edema) que não pode ser totalmente explicado por excesso de fluidos no corpo ou por problemas no coração. Essa síndrome pode aparecer como uma nova doença pulmonar aguda em crianças que já possuem doenças pulmonares crônicas e/ou doenças cardíacas. Doenças pulmonares que surgem no período próximo ao nascimento (perinatal) são excluídas.

Pesquisas ativas
11 ensaios
30 total registrados no ClinicalTrials.gov
Publicações científicas
449 artigos
Último publicado: 2026 Mar 23
🏥
SUS: Sem cobertura SUSScore: 0%
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🫁
Pulmão
7 sintomas
❤️
Coração
5 sintomas
😀
Face
1 sintomas

+ 11 sintomas em outras categorias

Características mais comuns

90%prev.
Hipoxemia
Muito frequente (99-80%)
55%prev.
Cianose
Frequente (79-30%)
55%prev.
Morfologia anormal do tórax
Frequente (79-30%)
55%prev.
Edema pulmonar
Frequente (79-30%)
55%prev.
Nascimento prematuro
Frequente (79-30%)
55%prev.
Insuficiência respiratória
Frequente (79-30%)
24sintomas
Muito frequente (1)
Frequente (8)
Ocasional (6)
Muito raro (1)
Sem dados (8)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 24 características clínicas mais associadas, ordenadas por frequência.

HipoxemiaHypoxemia
Muito frequente (99-80%)90%
CianoseCyanosis
Frequente (79-30%)55%
Morfologia anormal do tóraxAbnormal thorax morphology
Frequente (79-30%)55%
Edema pulmonarPulmonary edema
Frequente (79-30%)55%
Nascimento prematuroPremature birth
Frequente (79-30%)55%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico449PubMed
Últimos 10 anos200publicações
Pico202359 papers
Linha do tempo
2026Hoje · 2026🧪 2001Primeiro ensaio clínico📈 2023Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

Genes associados

3 genes identificados com associação a esta condição.

SFTPCSurfactant protein CMajor susceptibility factor inTolerante
FUNÇÃO

Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces

LOCALIZAÇÃO

Secreted, extracellular space, surface film

VIAS BIOLÓGICAS (3)
Surfactant metabolismDefective CSF2RB causes SMDP5Defective CSF2RA causes SMDP4
MECANISMO DE DOENÇA

Pulmonary surfactant metabolism dysfunction 2

A rare disease associated with progressive respiratory insufficiency and lung disease with a variable clinical course, due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.

EXPRESSÃO TECIDUAL(Tecido-específico)
Pulmão
1746.9 TPM
Brain Spinal cord cervical c-1
7.3 TPM
Brain Putamen basal ganglia
4.0 TPM
Brain Caudate basal ganglia
3.7 TPM
Córtex cerebral
3.5 TPM
OUTRAS DOENÇAS (5)
surfactant metabolism dysfunction, pulmonary, 2idiopathic pulmonary fibrosisSFTPC-related interstitial lung diseasepediatric acute respiratory distress syndrome
HGNC:10802UniProt:P11686
ABCA3Phospholipid-transporting ATPase ABCA3Candidate gene tested inTolerante
FUNÇÃO

Catalyzes the ATP-dependent transport of phospholipids such as phosphatidylcholine and phosphoglycerol from the cytoplasm into the lumen side of lamellar bodies, in turn participates in the lamellar bodies biogenesis and homeostasis of pulmonary surfactant (PubMed:16959783, PubMed:17574245, PubMed:27177387, PubMed:28887056, PubMed:31473345). Transports preferentially phosphatidylcholine containing short acyl chains (PubMed:27177387). In addition plays a role as an efflux transporter of miltefosi

LOCALIZAÇÃO

Endosome, multivesicular body membraneCytoplasmic vesicle membraneLate endosome membraneLysosome membrane

VIAS BIOLÓGICAS (2)
Surfactant metabolismABC transporters in lipid homeostasis
MECANISMO DE DOENÇA

Pulmonary surfactant metabolism dysfunction 3

A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.

INTERAÇÕES PROTEICAS (4)
OUTRAS DOENÇAS (4)
interstitial lung disease due to ABCA3 deficiencysurfactant metabolism dysfunction, pulmonary, 1idiopathic pulmonary fibrosispediatric acute respiratory distress syndrome
HGNC:33UniProt:Q99758
SFTPBPulmonary surfactant-associated protein BMajor susceptibility factor inTolerante
FUNÇÃO

Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter

LOCALIZAÇÃO

Secreted, extracellular space, surface film

VIAS BIOLÓGICAS (3)
Surfactant metabolismDefective CSF2RB causes SMDP5Defective CSF2RA causes SMDP4
MECANISMO DE DOENÇA

Pulmonary surfactant metabolism dysfunction 1

A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.

EXPRESSÃO TECIDUAL(Tecido-específico)
Pulmão
3425.7 TPM
Tireoide
37.6 TPM
Rim - Córtex
1.1 TPM
Cerebelo
0.5 TPM
Testículo
0.5 TPM
OUTRAS DOENÇAS (2)
surfactant metabolism dysfunction, pulmonary, 1pediatric acute respiratory distress syndrome
HGNC:10801UniProt:P07988

Variantes genéticas (ClinVar)

430 variantes patogênicas registradas no ClinVar.

🧬 SFTPB: NM_000542.5(SFTPB):c.439C>T (p.Gln147Ter) ()
🧬 SFTPB: NM_000542.5(SFTPB):c.1029_1031dup (p.Pro344_Gln345insPro) ()
🧬 SFTPB: GRCh37/hg19 2p11.2(chr2:85860694-85917890)x1 ()
🧬 SFTPB: NM_000542.5(SFTPB):c.195+1G>A ()
🧬 SFTPB: NM_000542.5(SFTPB):c.195+4A>G ()
Ver todas no ClinVar

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
Aprovado2
2Fase 22
·Pré-clínico16
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 20 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Síndrome pediátrica de dificuldade respiratória aguda

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Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

9 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

Outros ensaios clínicos

30 ensaios clínicos encontrados, 11 ativos.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
423 papers (10 anos)
#1

Prognostic significance of serum apelin-13 and galectin-3 concentrations as potential indicators of severity and mortality in pediatric acute respiratory distress syndrome.

The Turkish journal of pediatrics2026 Feb 27

The predictive and prognostic significance of apelin and galectin-3 as biomarkers in pediatric acute respiratory distress syndrome (PARDS) and lung injury has remained limited. This study examined the association between serum apelin-13 and galectin-3 levels, PARDS severity, and patient outcomes. The study included children aged 1 month to 18 years diagnosed with PARDS on admission to a pediatric intensive care unit, alongside age- and sex-matched outpatient controls. PARDS was diagnosed and classified by severity according to Second Pediatric Acute Lung Injury Consensus Conference (PALICC-2) guidelines, based on oxygenation indices for non-invasive and invasive ventilation. Exclusion criteria included prior transplants, chronic lung disease, cyanotic congenital heart disease, prolonged ventilation, and other major conditions. After informed parental consent, 3 mL of peripheral venous blood was collected from all participants. Serum samples for apelin-13 and galectin-3 were stored at -80°C and analyzed using commercial enzyme-linked immunosorbent assay (ELISA) kits. Demographic, clinical, and laboratory data were systematically recorded for analysis. The study and control groups were comparable in age and gender. Patients had significantly lower hemoglobin, hematocrit, red blood cell, calcium, and phosphorus levels, and higher neutrophil counts, C-reactive protein, and liver enzymes. Apelin-13 levels did not differ significantly between groups, wheras median galectin-3 levels were significantly higher in patients (p=0.003). Apelin-13 levels were significantly lower and galectin-3 levels significantly higher with increasing PARDS severity. Severe PARDS was associated with lower PaO2/FiO2 ratios, arterial pH, and higher ventilator pressures. Mortality was 36.4% in severe and 22.7% in moderate PARDS. Serum galectin-3 level was the sole independent predictor of mortality (OR: 1.20, 95% CI 1.02-1.39, p=0.02). Although the apelin/APJ system's role in acute lung injury is known, its diagnostic and prognostic value in PARDS requires further study. Galectin-3 levels correlate with disease severity and outcomes, highlighting the need for larger, age- and phenotype-homogenized studies to confirm its role as an independent mortality predictor.

#2

Burden and outcomes of pediatric acute respiratory distress syndrome among children with sepsis: a cohort study.

Frontiers in pediatrics2026

To determine the prevalence, clinical characteristics, outcomes, and mortality risk factors of pediatric acute respiratory distress syndrome (PARDS) among children with sepsis, and to compare pulmonary and extrapulmonary PARDS phenotypes. This retrospective cohort study analyzed children aged 0-14 years with Phoenix-defined sepsis admitted to a tertiary pediatric intensive care unit between 2015 and 2023. PARDS was defined according to PALICC-2 criteria. Demographics, illness severity, microbiology, organ support requirements, and clinical outcomes were compared between children with and without PARDS and between pulmonary and extrapulmonary phenotypes. Multivariable logistic regression models were used to identify independent predictors of mortality. Among 279 children with Phoenix-defined sepsis, 161 (57.7%) developed PARDS. Children with PARDS were younger, had higher PELOD-2 and Phoenix severity scores, and required significantly more mechanical ventilation, vasoactive support, and renal replacement therapy compared with those without PARDS. Mortality was substantially higher in the PARDS cohort (36.6% vs. 7.6%). Model-estimated mortality probability increased stepwise with worsening PARDS severity and was highest among children with both septic shock and severe PARDS. Pulmonary PARDS accounted for two-thirds of cases, whereas extrapulmonary PARDS demonstrated a higher inflammatory burden and more bacterial infections. In adjusted analyses, the presence of PARDS, higher PELOD-2 score, and greater cumulative fluid balance were independently associated with mortality. PARDS is a common and common complication associated with high risk of pediatric sepsis, associated with severe organ dysfunction, increased support requirements, and markedly elevated mortality. These findings underscore the need for multicenter validation to confirm the epidemiology and risk factors of sepsis-associated PARDS and to guide earlier recognition and management approaches for this high-risk population.

#3

Overexpression of IL-8 augments the susceptibility to a hyperinflammatory phenotype in pediatric acute respiratory distress syndrome and correlates with adverse outcomes: a retrospective two-center study conducted in northwest China.

Frontiers in pediatrics2026

The prognosis of acute respiratory distress syndrome (ARDS) varies with inflammatory responses. ARDS patients with a hyperinflammatory phenotype usually have worse alveolar epithelial injury and vascular endothelial injury than those carrying a hypoinflammatory phenotype. Activated neutrophils recruited and migrated in the lung tissue are responsible for stimulating the progression of ARDS. Interleukin-8 (IL-8), as an inflammatory factor, further aggravates lung damage in ARDS. This was a retrospective study involving 135 ARDS children admitted in two pediatric hospitals in northwest China. They were either classified into mild, moderate and severe groups based on the oxygenation index (OI) or oxygenation saturation index (OSI) within 4-h invasive mechanical ventilation on admission, or the survival and non-survival groups based on the 28-day mortality. Demographic and clinical data were analyzed. Risk factors for the prognosis of PARDS were identified by logistic regression. The correlation of IL-8 level with the identified risk factors was analyzed. Prognostic potential of IL-8 was determined by plotting the receiver operating characteristic (ROC) curves. IL-8, RAGE, Ang-2, ICAM-1 and SP-D were independent risk factors for the mortality of PARDS. They were significantly higher in the non-survival group than the survival group, showing a potential in predicting mortality in PARDS, especially in the combination (P < 0.05). IL-8 was positively correlated with RAGE, Ang-2, ICAM-1 and SP-D in children with ARDS (P < 0.05). IL-8 is overexpressed in children with ARDS, showing a prognostic potential particularly in combination with RAGE, Ang-2, ICAM-1 and SP-D in PARDS.

#4

Geographical and racial and/or ethnic disparities in pediatric ARDS mortality in the USA, 2016-2022: a triennial national database retrospective cohort analysis.

Lancet regional health. Americas2026 Feb

Disparities in pediatric critical care outcomes are recognized, but national data describing Pediatric Acute Respiratory Distress Syndrome (PARDS) prevalence, mortality and temporal trends are limited. We described prevalence, and regional and racial/ethnic mortality disparities for algorithm-defined ARDS, a surrogate for PARDS in US children from 2016 to 2022. We performed a retrospective cohort study using the 2016, 2019, and 2022 Kids' Inpatient Database (KID). Algorithm-defined ARDS was identified with an ICD-10 approach requiring acute respiratory failure from pulmonary, sepsis, or shock etiologies requiring invasive mechanical ventilation ≥24 h. The primary outcome was in-hospital mortality. Exposures were US region and Race/Ethnicity, modeled individually and jointly. Mixed-effect logistic regression models, adjusting for income quartile, APR-DRG severity of illness, hospital type, and complex chronic conditions, estimated adjusted mortalities and risk differences. Algorithm-defined ARDS occurred in about 42,000 hospitalizations per year, with prevalence increasing from 0.68% (95% CI 0.67-0.69) in 2016 to 0.75% (0.74-0.75) in 2022. Overall mortality was 12.9% (12.5-13.3) in 2016, 12.5% (12.1-12.9) in 2019, and 13.7% (13.3-14.1) in 2022. In the joint model, relative to Northeastern White children (predicted 10.9%, 95% CI 9.72-12.1), risks were higher for Black children in the South (predicted 14.2%, ARD 3.27%, 1.74-4.79) and West (14.6%, ARD 3.69%, 1.39-6.00); Hispanic children in the West (12.6%, ARD 1.70%, 0.09-3.31), and children of Other race/ethnicity in the South (16.5%, ARD 5.57%, 3.14-7.99) and West (14.0%, ARD 3.11%, 0.96-5.25). Disparities did not meaningfully change from 2016 to 2019, while mortality increased from 2019 to 2022. Algorithm-defined ARDS among hospitalized US children remains common and highly fatal. Persistent regional and racial/ethnic disparities highlight systemic drivers of inequity and the need for targeted interventions. This work was supported by the National Heart, Lung, and Blood Institute, National Institutes of Health (Award K23HL177271, PI: Keim).

#5

Continuous Infusion Versus Intermittent Boluses of Cisatracurium in the Early Management of Pediatric Acute Respiratory Distress Syndrome: A Multicenter, Randomized Controlled Trial.

Archivos de bronconeumologia2026 Feb 15

Pediatric acute respiratory distress syndrome (PARDS) is a critical condition associated with considerable morbidity and mortality. Trials in adults showed controversial results about neuromuscular blocking agents (NMBAs) use in adult acute respiratory distress syndrome. With limited data in PARDS, we sought to compare the outcomes of continuous cisatracurium infusion versus intermittent bolus administration in children with PARDS. This multicenter randomized controlled study was performed on patients with PARDS. Enrolled patients were categorized into: group I: patients treated with intermittent boluses of cisatracurium and group II: patients treated with intravenous infusion of cisatracurium for 24h. The primary outcome was the duration on mechanical ventilator (MV). Additional results included changes in ventilatory parameters, and length of pediatric intensive care unit (PICU) stay. Group II was associated with a significantly higher extubation from MV compared to group I, after accounting for death as a competing event. This association was confined to moderate-to-severe PARDS (subdistribution hazard ratio (SHR) 3.25, 95% CI 1.69-6.25, p<0.001) and not observed in mild PARDS. Similar with earlier PICU discharge, with stronger effect in moderate-to-severe disease (SHR 3.16, 95% CI 1.64-6.11, p<0.001). By day 7, patients with moderate-to-severe PARDS in group II showed lower fraction of inspired oxygen, mean airway pressure, and oxygenation index. In PARDS, cisatracurium infusion was associated with better oxygenation, earlier extubation from MV and shorter PICU stay compared to intermittent boluses, with benefits limited to moderate-to-severe disease. Outcomes were similar in mild PARDS.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC321 artigos no totalmostrando 200

2026

Investigating the role of miR-192-5p as a diagnostic biomarker and the anti-inflammatory function in pediatric acute respiratory distress syndrome.

BMC immunology
2026

Prognostic significance of serum apelin-13 and galectin-3 concentrations as potential indicators of severity and mortality in pediatric acute respiratory distress syndrome.

The Turkish journal of pediatrics
2026

Burden and outcomes of pediatric acute respiratory distress syndrome among children with sepsis: a cohort study.

Frontiers in pediatrics
2026

Continuous Infusion Versus Intermittent Boluses of Cisatracurium in the Early Management of Pediatric Acute Respiratory Distress Syndrome: A Multicenter, Randomized Controlled Trial.

Archivos de bronconeumologia
2025

Prone positioning in pediatric acute respiratory distress syndrome: a systematic review and meta-analysis of randomized controlled trials.

Frontiers in pediatrics
2026

Retrospective Assessment of the Oxygenation Index in Dogs Undergoing Mechanical Ventilation for Primary Pulmonary Parenchymal Disease.

Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)
2026

Overexpression of IL-8 augments the susceptibility to a hyperinflammatory phenotype in pediatric acute respiratory distress syndrome and correlates with adverse outcomes: a retrospective two-center study conducted in northwest China.

Frontiers in pediatrics
2026

Estimation of Transpulmonary Driving Pressure, Strain, and Lung-Specific Elastance Using Volumetric Methods in Invasively Ventilated Children-A Feasibility Study.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2026

Pediatric Acute Respiratory Distress Syndrome Supported With Invasive Mechanical Ventilation: Prevalence per PICU, per Week, in Spain, 2019-2021.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2026

Methylomic Analysis of Nasal Brushings Reveals Two Subgroups in Pediatric Acute Respiratory Distress Syndrome.

Research square
2026

Acute respiratory distress syndrome in the pediatric patient.

Medicina intensiva
2026

Geographical and racial and/or ethnic disparities in pediatric ARDS mortality in the USA, 2016-2022: a triennial national database retrospective cohort analysis.

Lancet regional health. Americas
2026

Risk factors for mortality in children with hypoxemia in resource-constrained settings: a secondary analysis of Global Paediatric Acute Critical Illness Point Prevalence Study (PARITY).

BMC global and public health
2025

Case Report: Successful weaning after 113 days of VV-ECMO in a pediatric patient with severe ARDS following Stevens-Johnson syndrome.

Frontiers in pediatrics
2025

Multi-omics analysis reveals distinct spatial compartmentalization of lung repair niches in pediatric ARDS.

Journal of translational medicine
2025

Inhaled nitric oxide in therapy of pediatric and neonatal acute respiratory distress syndrome: the good, the bad and the ugly.

Expert review of respiratory medicine
2025

Risk assessment of pARDS in severe pneumonia patients based on lung injury prediction scores and serum biomarkers.

Scientific reports
2025

ATS Pediatric Core Curriculum 2024: The Role of the Pediatric Pulmonologist in the Intensive Care Unit.

Pediatric pulmonology
2024

DISTRIBUTION OF RESPIRATORY VIRUSES IN CHILDREN ADMITTED TO PEDIATRIC INTENSIVE CARE UNIT.

Acta clinica Croatica
2025

Pediatric acute respiratory distress syndrome in children with type I - spinal muscular atrophy: a 12-year case series.

European journal of pediatrics
2025

Siblings in the ICU: Keeping Endemic Mycoses on the Differential.

Case reports in pediatrics
2025

Differentiating Lung From Chest Wall Mechanics Is Difficult Without Esophageal Manometry in Children With Acute Respiratory Distress Syndrome.

Critical care medicine
2025

Nutritional Status and Mechanical Ventilation Practices in Pediatric Acute Respiratory Distress Syndrome: A Secondary Analysis of the 2017-2023 PARDSAsia Study.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2025

Yes-associated protein induces age-dependent inflammatory signaling in the pulmonary endothelium.

American journal of physiology. Lung cellular and molecular physiology
2025

Epidemiology, outcomes, and factors associated with mortality in pediatric acute respiratory distress syndrome in hospitalized Thai children: a nationwide retrospective analysis, 2015-2022.

Critical care (London, England)
2025

Pneumonia Requiring Respiratory Support in the PICU: Single-Center Study of Admission Plasma Nucleosome, Histone, and Citrullinated Histone H3 Levels in Relation to Complications.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2025

Pediatric Acute Respiratory Distress Syndrome Updates in the Light of the PALICC-2 Guidelines.

Turkish archives of pediatrics
2025

Global Research Trends in Pediatric Acute Respiratory Distress Syndrome: A Bibliometric Analysis from 2014 To 2024.

Journal of epidemiology and global health
2025

Olfactomedin-4 elevation in pediatric acute respiratory distress syndrome.

American journal of physiology. Lung cellular and molecular physiology
2025

Plasma Soluble Intercellular Adhesion Molecule-1 Has a Central Role in Biomarker Network Analysis and Is Associated With Poor Outcomes in Two Distinct Pediatric Cohorts of Acute Respiratory Distress Syndrome and Acute Respiratory Failure.

Critical care medicine
2025

Clinical Outcomes of Children Meeting the At-Risk for PARDS Criteria Before PICU Admission: A Single-Center Study.

Pediatric pulmonology
2025

Development of an acute lung injury model for drug testing.

Scientific reports
2025

USP7-Mediated ICAM1 Facilitates Lipopolysaccharide-Induced Human Pulmonary Microvascular Endothelial Cell Injury to Accelerate Pediatric Acute Respiratory Distress Syndrome.

The clinical respiratory journal
2025

Tailoring ventilation and respiratory management in pediatric critical care: optimizing care with precision medicine.

Current opinion in pediatrics
2025

Severe Pneumonia and Pediatric Acute Respiratory Distress Syndrome Caused by HCoV NL 63 and Respiratory Syncytial Virus Coinfection With Favorable Outcome.

The Pediatric infectious disease journal
2025

The Prevalence and Outcome of Acute Hypoxemic Respiratory Failure (PANDORA) Study in Mechanically Ventilated Children: Prospective Multicenter Epidemiology in Spain, 2019-2021.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2025

What Is the New Research in Pediatric Acute Respiratory Distress Syndrome Since the 2023 Consensus Conference?

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2025

Efficacy and safety of extracorporeal membrane oxygenation combined with continuous renal replacement therapy in the management of pediatric acute respiratory distress syndrome.

Frontiers in pediatrics
2025

Pediatric Acute Respiratory Distress Syndrome in Bronchiolitis and Lower Airway Infection: What's New?

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2025

Right Atrial Dysfunction Is Prevalent in Pediatric Acute Respiratory Distress Syndrome and Reflects Pulmonary Hypertension and Right Ventricular Dysfunction.

Critical care explorations
2025

Effects of rescue airway pressure release ventilation on mortality in severe pediatric acute respiratory distress syndrome: a retrospective comparative analysis from India.

Acute and critical care
2025

Development and Validation of an Electronic Health Record-Based, Pediatric Acute Respiratory Distress Syndrome Subphenotype Classifier Model.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2025

Acute Respiratory Distress Syndrome in Children With Lower Respiratory Tract Infection Requiring Invasive Mechanical Ventilation: Post Hoc Analysis of the 2019-2020 Bronchiolitis and Codetection Cohort.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2025

"Evaluation of Different Inspiratory Efforts in a Pediatric Model of Healthy Lung and Pediatric Acute Respiratory Distress Syndrome During Optimized Pressure Support Ventilation and Proportional Assist Ventilation Plus (PAV+): A Bench Study.

Pediatric pulmonology
2025

EIT guided evaluation of regional ventilation distributions in neonatal and pediatric ARDS: a prospective feasibility study.

Respiratory research
2025

Inhaled Epoprostenol in Children With Pediatric Acute Respiratory Distress Syndrome: A Single-Center Retrospective Study.

Pediatric pulmonology
2025

Modified lung ultrasound score for improved monitoring of pARDS on ECMO, a case report.

BMC pediatrics
2025

Genuine Deteriorating Signs of Pediatric Acute Respiratory Distress Syndrome.

Critical care medicine
2024

[Can CPAP prevent the progression of pediatric acute respiratory distress syndrome? A decade of experience in a Reference Center].

Andes pediatrica : revista Chilena de pediatria
2025

Esophageal Manometry in Pediatric Acute Respiratory Distress Syndrome: Necessity or Simply a Neighbor of the Pulmonary Artery Catheter?

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2024

Respiratory Syncytial Virus Infections in Pediatric Intensive Care: Association of Sociodemographic Data and Clinical Outcomes with Viral and Bacterial Co-infections.

Turkish archives of pediatrics
2024

Phenotypes based on respiratory drive and effort to identify the risk factors when P0.1 fails to estimate ∆PES in ventilated children.

Critical care (London, England)
2024

RNA Sequencing Analysis of Monocytes Exposed to Airway Fluid From Children With Pediatric Acute Respiratory Distress Syndrome.

Critical care explorations
2024

CIRCULATING HEPARAN SULFATE PROFILES IN PEDIATRIC ACUTE RESPIRATORY DISTRESS SYNDROME.

Shock (Augusta, Ga.)
2024

Impact of the transpulmonary pressure on right ventricle impairment incidence during acute respiratory distress syndrome: a pilot study in adults and children.

Intensive care medicine experimental
2025

Transpulmonary Pressure-Guided Mechanical Ventilation in Severe Acute Respiratory Distress Syndrome in the PICU: Single-Center Retrospective Study in North India, 2018-2021.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2025

MiR-629-5p May serve as a biomarker for pediatric acute respiratory distress syndrome and can regulate the inflammatory response.

Pediatrics and neonatology
2024

The impact of PEEP on mechanical power and driving pressure in children with pediatric acute respiratory distress syndrome.

Pediatric pulmonology
2024

Mechanical Power in Decelerating Flow versus Square Flow Ventilation in Pediatric Acute Respiratory Distress Syndrome.

Anesthesiology
2024

Pneumatocele in focus: EIT's colors of the invisible.

Pediatric pulmonology
2024

The Impact of Increased PEEP on Hemodynamics, Respiratory Mechanics, and Oxygenation in Pediatric ARDS.

Respiratory care
2024

[Prognostic factors of extracorporeal membrane oxygenation in the treatment of severe pediatric acute respiratory distress syndrome].

Zhonghua er ke za zhi = Chinese journal of pediatrics
2024

Lung-Protective Ventilation for Pediatric Acute Respiratory Distress Syndrome: A Nonrandomized Controlled Trial.

Critical care medicine
2024

New Right Ventricular Dysfunction in Pediatric Acute Respiratory Distress Syndrome on Venovenous Extracorporeal Membrane Oxygenation.

ASAIO journal (American Society for Artificial Internal Organs : 1992)
2024

Evaluation of the classifications of severity in acute respiratory distress syndrome in childhood by the Berlin Consensus and the Pediatric Acute Lung Injury Consensus Conference.

Critical care science
2024

Pediatric Acute Respiratory Distress Syndrome Severity and Health-Related Quality of Life Outcomes: Single-Center Retrospective Cohort, 2011-2017.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2024

Protocol for the Prone and Oscillation Pediatric Clinical Trial ( PROSpect ).

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2024

Time to split: biomarker trajectories in pediatric acute respiratory distress syndrome hint at underlying disease.

The Journal of clinical investigation
2024

Time Course of Mechanical Ventilation Driving Pressure Levels in Pediatric Acute Respiratory Distress Syndrome: Outcomes in a Prospective, Multicenter Cohort Study From Colombia, 2018-2022.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2024

Lung behavior during a staircase high-frequency oscillatory ventilation recruitment maneuver.

Intensive care medicine experimental
2024

Biomarker-Based Risk Stratification Tool in Pediatric Acute Respiratory Distress Syndrome: Single-Center, Longitudinal Validation in a 2014-2019 Cohort.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2024

Inflammatory and tissue injury marker dynamics in pediatric acute respiratory distress syndrome.

The Journal of clinical investigation
2024

Definition, Incidence, and Epidemiology of Pediatric Acute Respiratory Distress Syndrome: From the Second Pediatric Acute Lung Injury Consensus Conference: Erratum.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2024

Executive Summary of the Second International Guidelines for the Diagnosis and Management of Pediatric Acute Respiratory Distress Syndrome (PALICC-2): Erratum.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2024

About the Second International Guidelines for the Diagnosis and Management of Pediatric Acute Respiratory Distress Syndrome.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2024

Healthcare Burden and Resource Utilization After Pediatric Acute Respiratory Distress Syndrome: A Secondary Analysis of the Collaborative Pediatric Critical Care Research Network Acute Respiratory Distress Syndrome Study.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2024

Respiratory System Compliance Accurately Assesses the "Baby Lung" in Pediatric Acute Respiratory Distress Syndrome.

American journal of respiratory and critical care medicine
2024

Mechanical power and normalized mechanical power in pediatric acute respiratory distress syndrome.

Frontiers in pediatrics
2024

Use of point-of-care ultrasound (POCUS) to monitor neonatal and pediatric extracorporeal life support.

European journal of pediatrics
2024

Immunocompromised-Associated Pediatric Acute Respiratory Distress Syndrome: Experience From the 2016/2017 Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Prospective Cohort Study.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2024

So, You Say You Want a Revolution? You Tell Me That It's Evolution: Associating Temporal Changes in Pediatric Acute Respiratory Distress Syndrome Plasma Biomarkers With Lung Injury Severity.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2024

Positive end-expiratory pressure in the pediatric intensive care unit.

Paediatric respiratory reviews
2024

Indirect cardiac output assessment in a swine pediatric acute respiratory distress syndrome model.

Respiratory physiology &amp; neurobiology
2023

Lung mechanics in pediatric acute respiratory distress syndrome associated to acute COVID-19 and MIS-C: implications for therapies and outcomes.

Andes pediatrica : revista Chilena de pediatria
2023

[Interpretation of the second edition of pediatric acute respiratory distress syndrome consensus].

Zhonghua er ke za zhi = Chinese journal of pediatrics
2023

Assessment of the Clinical Course of Human Rhinovirus/Enterovirus Infections in Pediatric Intensive Care.

The Pediatric infectious disease journal
2023

Venovenous Versus Venoarterial Extracorporeal Membrane Oxygenation: Pediatric Acute Respiratory Distress Syndrome.

Turkish archives of pediatrics
2023

Surfactant Deficiency Causing Severe Pneumonia in a Child.

Current health sciences journal
2023

Case report: Miliary tuberculosis complicated by pediatric acute respiratory distress syndrome in a 12-year-old girl.

Frontiers in pediatrics
2024

Endothelial Glycocalyx Degradation Patterns in Sepsis-Associated Pediatric Acute Respiratory Distress Syndrome: A Single Center Retrospective Observational Study.

Journal of intensive care medicine
2023

Noninvasive Ventilation in Pediatric Acute Respiratory Distress Syndrome: "Another Dogma Bites the Dust".

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2023

Editor's Choice Articles for September.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2023

Cardiac dysfunction in severe pediatric acute respiratory distress syndrome: the right ventricle in search of the right therapy.

Frontiers in medicine
2023

Pediatric Acute Respiratory Distress Syndrome and Tracheal Injury in a Patient Requiring Extracorporeal Membrane Oxygenation Following Cement Aspiration: A Case Report.

Critical care explorations
2023

Clinical characterization of human bocavirus 1 infection in infants hospitalized in an intensive care unit for severe acute respiratory tract disease.

Diagnostic microbiology and infectious disease
2023

Capnometry after an inspiratory breath hold, PLAT CO2 , as a surrogate for P aCO 2 ${P}_{{\mathrm{aCO}}_{2}}$ in mild to moderate pediatric acute respiratory distress syndrome: A feasibility study.

Pediatric pulmonology
2023

The Modified Clinical Progression Scale for Pediatric Patients: Evaluation as a Severity Metric and Outcome Measure in Severe Acute Viral Respiratory Illness.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2023

Pediatric Acute Respiratory Distress Syndrome in South African PICUs: A Multisite Point-Prevalence Study.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2023

Association between pediatric intensive care mortality and mechanical ventilation settings during extracorporeal membrane oxygenation for pediatric acute respiratory distress syndrome.

European journal of pediatrics
2023

Pediatric acute respiratory distress syndrome in a Moroccan intensive care unit: a retrospective observational study of 23 cases.

The Pan African medical journal
2024

Venovenous Extracorporeal Membrane Oxygenation Initiation for Pediatric Acute Respiratory Distress Syndrome With Cardiovascular Instability is Associated With an Immediate and Sustained Decrease in Vasoactive-Inotropic Scores.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2023

Prevention of Pediatric Acute Respiratory Distress Syndrome: The Holy Grail Remains Elusive.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2023

Association of Interventions With Outcomes in Children At-Risk for Pediatric Acute Respiratory Distress Syndrome: A Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Study.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2023

Editor's Choice Articles for July.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2023

Single cell transcriptomics identifies distinct profiles in pediatric acute respiratory distress syndrome.

Nature communications
2024

Comparison of 16 Pediatric Acute Respiratory Distress Syndrome-Associated Plasma Biomarkers With Changing Lung Injury Severity.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2023

RNA Sequencing Analysis of CD4+ T Cells Exposed to Airway Fluid From Children With Pediatric Acute Respiratory Distress Syndrome.

Critical care explorations
2023

Derivation, Validation, and Clinical Relevance of a Pediatric Sepsis Phenotype With Persistent Hypoxemia, Encephalopathy, and Shock.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2023

Plateau Pressure and Driving Pressure in Volume- and Pressure-Controlled Ventilation: Comparison of Frictional and Viscoelastic Resistive Components in Pediatric Acute Respiratory Distress Syndrome.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2023

Noninvasive Ventilation for Pediatric Acute Respiratory Distress Syndrome: Experience From the 2016/2017 Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Prospective Cohort Study.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2023

Corticosteroids treatment for pediatric acute respiratory syndrome: A critical review.

Saudi medical journal
2023

Sepsis-related pediatric acute respiratory distress syndrome: A multicenter prospective cohort study.

Turkish journal of emergency medicine
2023

Evaluation of Patients with Acute Respiratory Distress Syndrome Followed on Mechanical Ventilator in a Tertiary Pediatric Intensive Care and the Factors That May Be Associated with Death in These Patients.

Turkish archives of pediatrics
2023

Prevalence and Incidence of Pediatric Acute Respiratory Distress Syndrome in a Tertiary Academic PICU in South Africa.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2023

Stratifying Severity of Acute Respiratory Failure Severity in Cyanotic Congenital Heart Disease.

Pediatric cardiology
2023

Identification of a pediatric acute hypoxemic respiratory failure signature in peripheral blood leukocytes at 24 hours post-ICU admission with machine learning.

Frontiers in pediatrics
2023

Association between serum HMGB1 elevation and early pediatric acute respiratory distress syndrome: a retrospective study of pediatric living donor liver transplant recipients with biliary atresia in China.

BMC anesthesiology
2023

Fluid Overload Precedes and Masks Cryptic Kidney Injury in Pediatric Acute Respiratory Distress Syndrome.

Critical care medicine
2023

A Web-Based Platform for the Automatic Stratification of ARDS Severity.

Diagnostics (Basel, Switzerland)
2023

Extracorporeal Membrane Oxygenation Then and Now; Broadening Indications and Availability.

Critical care clinics
2023

Mechanical Power Is Associated With Mortality in Pediatric Acute Respiratory Distress Syndrome.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2023

[Analysis of risk factors of mortality in infants and toddlers with moderate to severe pediatric acute respiratory distress syndrome].

Zhonghua er ke za zhi = Chinese journal of pediatrics
2023

Nutritional Support in Children Meeting the At-Risk for Pediatric Acute Respiratory Distress Syndrome Criteria.

Critical care explorations
2023

The end-tidal alveolar dead space fraction for risk stratification during the first week of invasive mechanical ventilation: an observational cohort study.

Critical care (London, England)
2023

Prone Positioning Improved Ventilation-Perfusion Matching in Severe Pediatric Acute Respiratory Distress Syndrome.

American journal of respiratory and critical care medicine
2023

Comparison of Pediatric Patients With and Without Multisystem Inflammatory Syndrome Associated With COVID-19: Retrospective Cohort From Ecuador.

The Pediatric infectious disease journal
2023

Immunocompromised Children With Acute Respiratory Distress Syndrome Possess a Distinct Circulating Inflammatory Profile.

Critical care explorations
2023

Adult-size interface during non-invasive ventilation for a child with pediatric acute respiratory distress syndrome: Maintaining principle on a different population.

Clinical case reports
2022

PRISM III Score Predicts Short-Term Outcome in Children with ARDS on Conventional and High-Frequency Oscillatory Ventilation.

Children (Basel, Switzerland)
2023

Diagnostic, Management, and Research Considerations for Pediatric Acute Respiratory Distress Syndrome in Resource-Limited Settings: From the Second Pediatric Acute Lung Injury Consensus Conference.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2023

Noninvasive Respiratory Support for Pediatric Acute Respiratory Distress Syndrome: From the Second Pediatric Acute Lung Injury Consensus Conference.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2023

Extracorporeal Membrane Oxygenation in Pediatric Acute Respiratory Distress Syndrome: From the Second Pediatric Acute Lung Injury Consensus Conference.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2023

Monitoring in Pediatric Acute Respiratory Distress Syndrome: From the Second Pediatric Acute Lung Injury Consensus Conference.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2023

Pulmonary Specific Ancillary Treatment for Pediatric Acute Respiratory Distress Syndrome: From the Second Pediatric Acute Lung Injury Consensus Conference.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2023

Definition, Incidence, and Epidemiology of Pediatric Acute Respiratory Distress Syndrome: From the Second Pediatric Acute Lung Injury Consensus Conference.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2023

Methodology of the Second Pediatric Acute Lung Injury Consensus Conference.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2023

Invasive Ventilatory Support in Patients With Pediatric Acute Respiratory Distress Syndrome: From the Second Pediatric Acute Lung Injury Consensus Conference.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2023

Nonpulmonary Treatments for Pediatric Acute Respiratory Distress Syndrome: From the Second Pediatric Acute Lung Injury Consensus Conference.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2023

Outcomes of Children Surviving Pediatric Acute Respiratory Distress Syndrome: From the Second Pediatric Acute Lung Injury Consensus Conference.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2023

Pathobiology, Severity, and Risk Stratification of Pediatric Acute Respiratory Distress Syndrome: From the Second Pediatric Acute Lung Injury Consensus Conference.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2023

Leveraging Clinical Informatics and Data Science to Improve Care and Facilitate Research in Pediatric Acute Respiratory Distress Syndrome: From the Second Pediatric Acute Lung Injury Consensus Conference.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2023

Executive Summary of the Second International Guidelines for the Diagnosis and Management of Pediatric Acute Respiratory Distress Syndrome (PALICC-2).

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2022

Expression Patterns of Airway Fluid Cytokines From Intubated Children With Pediatric Acute Respiratory Distress Syndrome.

Critical care explorations
2023

Pediatric Acute Respiratory Distress Syndrome: Approaches in Mechanical Ventilation.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2022

The longitudinal course of pediatric acute respiratory distress syndrome and its time to resolution: A prospective observational study.

Frontiers in pediatrics
2022

Analysis of predictors of mortality and clinical outcomes of different subphenotypes for moderate-to-severe pediatric acute respiratory distress syndrome: A prospective single-center study.

Frontiers in pediatrics
2023

Alveolar dead space fraction is not associated with early RV systolic dysfunction in pediatric ARDS.

Pediatric pulmonology
2024

Fluid Overload in Pediatric Acute Respiratory Distress Syndrome after Allogeneic Hematopoietic Cell Transplantation.

Journal of pediatric intensive care
2023

Clinical outcomes according to timing to invasive ventilation due to noninvasive ventilation failure in children.

Medicina intensiva
2022

Pediatric Acute Respiratory Distress Syndrome in India: Time for Collaborative Study?

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
2022

Plasma microRNA and metabolic changes associated with pediatric acute respiratory distress syndrome: a prospective cohort study.

Scientific reports
2022

P50 implies adverse clinical outcomes in pediatric acute respiratory distress syndrome by reflecting extrapulmonary organ dysfunction.

Scientific reports
2022

Evolution of multiple omics approaches to define pathophysiology of pediatric acute respiratory distress syndrome.

eLife
2022

Clinical characteristics of pediatric patients with acute respiratory distress syndrome due to COVID-19.

Boletin medico del Hospital Infantil de Mexico
2022

Multi-omic characterization of pediatric ARDS via nasal brushings.

Respiratory research
2022

Challenges Remain to Assess Post-ICU Morbidity and Identify Attributable Risk in Children With Pediatric Acute Respiratory Distress Syndrome.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2022

Nonadherence to appropriate tidal volume and PEEP in children with pARDS at a single center.

Pediatric pulmonology
2022

Lung Recruitment Maneuvers Assessment by Bedside Lung Ultrasound in Pediatric Acute Respiratory Distress Syndrome.

Children (Basel, Switzerland)
2022

Comparison of Global and Regional Compliance-Guided Positive End-Expiratory Pressure Titration on Regional Lung Ventilation in Moderate-to-Severe Pediatric Acute Respiratory Distress Syndrome.

Frontiers in medicine
2022

Pediatric Acute Respiratory Distress Syndrome in COVID-19 Pandemic: Is it the Puzzle of the Century?

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
2022

Effects of microRNA-101-3p on predicting pediatric acute respiratory distress syndrome and its role in human alveolar epithelial cell.

Bioengineered
2022

Assessment of Patient Health-Related Quality of Life and Functional Outcomes in Pediatric Acute Respiratory Distress Syndrome.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2022

Lung Ultrasound in Pediatric Acute Respiratory Distress Syndrome Received Extracorporeal Membrane Oxygenation: A Prospective Cohort Study.

Frontiers in pediatrics
2022

Venovenous vs. Venoarterial Extracorporeal Membrane Oxygenation in Infection-Associated Severe Pediatric Acute Respiratory Distress Syndrome: A Prospective Multicenter Cohort Study.

Frontiers in pediatrics
2022

Acute Respiratory Distress Syndrome Management in Pediatric Intensive Care Units in Turkey: A Prospective Survey.

Turkish archives of pediatrics
2021

Mechanical Ventilation in Pediatric and Neonatal Patients.

Frontiers in physiology
2022

Early Restrictive Fluid Strategy Impairs the Diaphragm Force in Lambs with Acute Respiratory Distress Syndrome.

Anesthesiology
2022

Normalization to Predicted Body Weight May Underestimate Mechanical Energy in Pediatric Acute Respiratory Distress Syndrome.

American journal of respiratory and critical care medicine
2022

The Association Between Alveolar Dead Space Fraction and Mortality in Pediatric Acute Respiratory Distress Syndrome: A Prospective Cohort Study.

Frontiers in pediatrics
2022

High flow nasal cannula in the pediatric intensive care unit.

Expert review of respiratory medicine
2022

Pediatric Acute Respiratory Distress Syndrome-Will We Be Able to Predict It and Eventually Prevent It?

Critical care medicine
2025

Usefulness of implementation of a protective mechanical ventilation bundle during extracorporeal membrane oxygenation for pediatric acute respiratory distress syndrome.

Minerva pediatrics
2021

Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Pediatric Acute Respiratory Distress Syndrome.

Turkish thoracic journal
2022

Early Neuromuscular Blockade in Moderate-to-Severe Pediatric Acute Respiratory Distress Syndrome.

Critical care medicine
2022

Agreement Between Peak Inspiratory Pressure in Decelerating-Flow Ventilation and Plateau Pressure in Square-Flow Ventilation in Pediatric Acute Respiratory Distress Syndrome.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2022

Mechanical power in pediatric acute respiratory distress syndrome: a PARDIE study.

Critical care (London, England)
2022

Nutrition practices and outcomes in patients with pediatric acute respiratory distress syndrome.

JPEN. Journal of parenteral and enteral nutrition
2021

Cluster analysis and profiling of airway fluid metabolites in pediatric acute hypoxemic respiratory failure.

Scientific reports
2022

Advances in the Pharmacological Management of Pediatric Acute Respiratory Distress Syndrome.

Expert opinion on pharmacotherapy
2021

Potential therapeutics in pediatric acute respiratory distress syndrome: what does the immune system have to offer? A narrative review.

Translational pediatrics
2021

Influenza Virus Associated Pediatric Acute Respiratory Distress Syndrome: Clinical Characteristics and Outcomes.

Journal of tropical pediatrics
2021

Correlation Between the Ratio of Oxygen Saturation to Fraction of Inspired Oxygen and the Ratio of Partial Pressure of Oxygen to Fraction of Inspired Oxygen in Detection and Risk Stratification of Pediatric Acute Respiratory Distress Syndrome.

Cureus
2022

Case study: Cinnamon aspiration in a toddler causing severe ARDS requiring surfactant and extracorporeal membrane oxygenation.

Pediatric pulmonology
2022

Beyond the Alveolar Epithelium: Plasma Soluble Receptor for Advanced Glycation End Products Is Associated With Oxygenation Impairment, Mortality, and Extrapulmonary Organ Failure in Children With Acute Respiratory Distress Syndrome.

Critical care medicine
2024

Correlation and Prediction of Oxygen Index from Oxygen Saturation Index in Neonates with Acute Respiratory Failure.

American journal of perinatology
2021

Evaluating the impact of heterogeneity on results of meta analyses evaluating nutritional status and clinical outcomes in pediatric intensive care.

Clinical nutrition (Edinburgh, Scotland)
2021

Acute Hypoxemic Respiratory Failure in Children at the Start of COVID-19 Outbreak: A Nationwide Experience.

Journal of clinical medicine
2022

Fluid overload in children with pediatric acute respiratory distress syndrome: A retrospective cohort study.

Pediatric pulmonology
2022

Oxygenation Defects, Ventilatory Ratio, and Mechanical Power During Severe Pediatric Acute Respiratory Distress Syndrome: Longitudinal Time Sequence Analyses in a Single-Center Retrospective Cohort.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2022

Epidemiology and Outcomes of Critically Ill Children at Risk for Pediatric Acute Respiratory Distress Syndrome: A Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Study.

Critical care medicine
2022

Ventilation Parameters Before Extracorporeal Membrane Oxygenator and In-Hospital Mortality in Children: A Review of the ELSO Registry.

ASAIO journal (American Society for Artificial Internal Organs : 1992)
2021

Adherence to Lung-Protective Ventilation in Pediatric Acute Respiratory Distress Syndrome: Principles Versus Explicit Targets.

Critical care medicine
2021

Income-driven socioeconomic status and presenting illness severity in children with acute respiratory failure.

Research in nursing &amp; health
2021

Questions About Fluid Management in Pediatric Acute Respiratory Distress Syndrome and the Design of Clinical Trials.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2021

First case of low-dose umbilical cord blood therapy for pediatric acute respiratory distress syndrome induced by Pneumocystis carinii pneumonia.

European journal of medical research
2021

Hemadsorption as rescue therapy for patients with multisystem organ failure in pediatric intensive care-Report of two cases reports and review of the literature.

Artificial organs
2021

Recombinant human thrombomodulin for pneumonia-induced severe ARDS complicated by DIC in children: a preliminary study.

Journal of anesthesia
2021

Adherence to Lung-Protective Ventilation Principles in Pediatric Acute Respiratory Distress Syndrome: A Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Study.

Critical care medicine
2021

Large scale cytokine profiling uncovers elevated IL12-p70 and IL-17A in severe pediatric acute respiratory distress syndrome.

Scientific reports
2023

Predictors of Failure of Noninvasive Ventilation in Critically Ill Children.

Journal of pediatric intensive care
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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Prognostic significance of serum apelin-13 and galectin-3 concentrations as potential indicators of severity and mortality in pediatric acute respiratory distress syndrome.
    The Turkish journal of pediatrics· 2026· PMID 41871558mais citado
  2. Burden and outcomes of pediatric acute respiratory distress syndrome among children with sepsis: a cohort study.
    Frontiers in pediatrics· 2026· PMID 41777563mais citado
  3. Overexpression of IL-8 augments the susceptibility to a hyperinflammatory phenotype in pediatric acute respiratory distress syndrome and correlates with adverse outcomes: a retrospective two-center study conducted in northwest China.
    Frontiers in pediatrics· 2026· PMID 41710013mais citado
  4. Geographical and racial and/or ethnic disparities in pediatric ARDS mortality in the USA, 2016-2022: a triennial national database retrospective cohort analysis.
    Lancet regional health. Americas· 2026· PMID 41551924mais citado
  5. Continuous Infusion Versus Intermittent Boluses of Cisatracurium in the Early Management of Pediatric Acute Respiratory Distress Syndrome: A Multicenter, Randomized Controlled Trial.
    Archivos de bronconeumologia· 2026· PMID 41760463mais citado
  6. Positive end-expiratory pressure in pediatric acute respiratory distress syndrome: a narrative review.
    Transl Pediatr· 2026· PMID 41982967recente
  7. Association of peripheral blood lymphocytes and immunoglobulins with disease severity in pediatric acute respiratory distress syndrome: an age-stratified retrospective study.
    BMC Pediatr· 2026· PMID 41981552recente
  8. Re-evaluating early high-frequency oscillatory ventilation in moderate-to-severe pediatric ARDS: evidence from a genetic matching analysis.
    Front Med (Lausanne)· 2026· PMID 41958597recente
  9. Closed-loop synchronization versus conventional synchronization in spontaneously breathing pediatric patients (CHESTSIPP) - a randomized controlled cross-over study.
    Front Med (Lausanne)· 2026· PMID 41958566recente
  10. Ultrasound-guided lung recruitment maneuver in pediatric acute respiratory distress syndrome.
    Sci Rep· 2026· PMID 41942542recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:685082(Orphanet)
  2. MONDO:0100131(MONDO)
  3. Variantes catalogadas(ClinVar)
  4. Busca completa no PubMed(PubMed)
  5. Artigo Wikipedia(Wikipedia)

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