Necrose avascular da cabeça do fêmur, forma familiar

EMPHASYS Cup Positioning in THA With Non-Invasive Navigation (Velys Hip Navigation (VHN))

NCT06631638

Early Feasibility Study of Cartilage Defect Repair

NCT06823089

Influence of Antiseptic Washes on Wound Healing Complications After THA

NCT07104084

Alendronate for Osteonecrosis in Adults With Sickle Cell Disease

NCT06016634

DEXA Bone Density Analysis of the CoreHip® Prosthesis System

NCT06632301

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NCT06631638 · EMPHASYS Cup Positioning in THA With Non-Invasive Navigation…Recrutando

NCT06823089 · Early Feasibility Study of Cartilage Defect RepairRecrutando

NCT07104084 · Influence of Antiseptic Washes on Wound Healing Complication…Recrutando

NCT06016634 · Alendronate for Osteonecrosis in Adults With Sickle Cell Dis…Recrutando

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NCT06632301 · DEXA Bone Density Analysis of the CoreHip® Prosthesis SystemEm breve

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Timeline de publicações

196 papers (10 anos)

#1

Familial Cases of Legg-Calvé-Perthes Disease-Hemostatic and Molecular Markers.

International journal of molecular sciences2026 Feb 26

Legg-Calvé-Perthes disease (LCPD) is a rare disease caused by avascular necrosis of the femoral head. Although its etiology is still not fully understood, evidence suggests that heritable prothrombotic and inflammatory factors, as well as environmental factors, may be implicated in its onset and progress. The objective of this study is to describe the genetic, biochemical, and environmental factors that may be associated with the etiology of LCPD. This study was conducted in three families and included seven related patients with an LCPD diagnosis. We evaluated the following gene alterations using real-time PCR: MTHFR, CBS, COL1A1, COL2A1, PT, FVL, FVIII, FIX, PAI-1, eNOS, IL-23R, TNF-α, RANNK, RANNK-L, OPG and IL-6. Additionally, we assessed fourteen thrombophilia-associated biochemical markers, as well as environmental factors that may be associated with the etiology of LCPD in family cases. The results show different hemostatic alterations in every individual analyzed, presenting out-of-range values in one or more parameters. Concentrations of hemoglobin and fibrinogen and the FIX activity percentage showed statistically significant differences (p < 0.001) when compared with healthy controls. All patients presented at least one mutated allele for the MTFHR (rs1801133), IL-23R (rs1569922) and OPG (rs2073618) polymorphisms, as well as isolated cases with other genetic variants. Our results show environmental elements from every family, and hemostatic and inflammatory disorders, may be involved in the development of LCPD. Furthermore, genetic variants could contribute to the onset of the disease. This study highlights the multifactorial nature of this pathology, involving various environmental, genetic, inflammatory, and prothrombotic factors in three families that included seven patients diagnosed with LCPD.

#2

Total Hip Arthroplasty in Lubumbashi (DR Congo), Outcomes in a Resource-Limited Setting.

Journal of orthopaedic case reports2026 Mar

Total hip arthroplasty (THA) is well established in high-income countries but remains challenging in sub-Saharan Africa due to limited implant availability, inadequate infrastructure, and financial constraints. This study presents a 7 year experience of THA in Lubumbashi, Democratic Republic of Congo, focusing on both clinical outcomes and the strategies developed to overcome local challenges. We retrospectively analyzed 60 THAs performed on 58 patients (mean age 53.8 years) between 2017 and 2024 at Medpark Clinic. The main indication was femoral head osteonecrosis (71.6%), including 11 cases in patients with sickle cell disease. All procedures used a transgluteal approach, with implant choice adapted to bone quality and availability. Rehabilitation emphasized early mobilization despite limited physiotherapy resources. At a mean follow-up of 4.5 years, functional outcomes improved markedly, with the Postel-Merle d'Aubigné score rising from 6.4 preoperatively to 16.2 at six months. Excellent or good results were achieved in 90.7% of cases. Complications occurred in 17.2% of patients, including dislocations (6.6%), infections (6.6%), periprosthetic fractures (3.3%), aseptic loosening (3.3%), one pulmonary embolism (1.6 %), and two deaths (3.3%). Barriers included high implant costs and irregular supply, addressed through long-term supplier partnerships and flexible payment plans. Infection control limitations were mitigated by strict asepsis protocols, povidone-iodine lavage, and selective use of antibiotic-loaded cement. In the absence of formal rehabilitation centers, structured patient and family education with early weight-bearing protocols facilitated recovery. Socioeconomic barriers were partially alleviated by forfait-based pricing and community financing mechanisms. Despite significant structural and economic constraints, THA can be safely and effectively implemented in resource-limited African settings when supported by careful surgical planning, tailored implant strategies, strict infection control, and innovative solutions to financial and logistical barriers.

#3

Severe Radiographic Legg-Calvé-Perthes Disease With Favorable Long-Term Functional Outcomes Following Conservative Management: A Case Report.

Cureus2026 Feb

Legg-Calvé-Perthes disease (LCPD) is a pediatric disorder characterized by avascular necrosis of the femoral head, with prognosis largely determined by the extent of epiphyseal involvement. Severe radiographic classifications are typically associated with poor long-term outcomes and often prompt surgical intervention. We present a case of a male patient diagnosed with unilateral LCPD at age three with extensive femoral head involvement by age six (Catterall Group 4, Salter-Thompson Group B, Herring Group C) who was managed non-operatively over two decades. Treatment consisted of physiotherapy, activity modification, and pain management without surgical intervention. Despite marked femoral head deformity and residual limitations in hip range of motion, the patient achieved high functional capacity, including participation in National Collegiate Athletic Association (NCAA) Division I athletics, and he maintains independence in activities of daily living as a young adult. This case highlights the potential for favorable functional outcomes with conservative management in carefully selected patients with poor-prognosis LCPD and underscores the importance of individualized treatment planning.

#4

A Novel Multisite Peripheral Nerve Stimulation Approach for Chronic Hip Pain in Avascular Necrosis: A Case Report.

Pain medicine case reports2026 Feb

Avascular necrosis (AVN) is a progressive disease, commonly leading to joint collapse and severe pain. Peripheral nerve stimulation (PNS) to the lumbar plexus and articular nerves innervating the hip can be a viable option for treatment of hip pain in patients who are not eligible for surgery. A patient with AVN-induced hip pain received bilateral lumbar plexus PNS at the level of L2, resulting in a > 90% relief of bilateral posterolateral aspects of the hip and 50% to 60% reduction in overall hip pain, respectively, at his 2-week follow-up. He subsequently underwent PNS placement to the articular branches of the femoral nerves bilaterally, resulting in improved coverage of the anterior groin leading to a 75% reduction in overall bilateral hip pain. Our case supports the utility of PNS to the lumbar plexus and articular nerve branches innervating the hip joint as a safe and novel treatment for chronic hip pain, despite limited evidence available for lumbar plexus neuromodulation.

#5

Factors That Increase the Risk of Prosthetic Joint Infection Within 90 Days After THA and TKA: A Nationwide Population-based Study.

Clinical orthopaedics and related research2026 Jan 01

Prosthetic joint infection (PJI) after THA and TKA is a serious complication. Although previous studies have identified risk factors for overall and late-onset PJI, limited research has focused specifically on infections occurring within the immediate 90-day postoperative period, a time frame critical for assessing surgical quality and early recovery outcomes. What patient and clinical factors are associated with the development of PJI within 90 days after primary THA or TKA? This was a retrospective, controlled study drawn from a longitudinally maintained, large, national database (the Taiwan National Health Insurance Research Database [NHIRD]). The NHIRD, covering > 99% of the population, provides comprehensive data for reliably identifying and tracking postoperative complications such as PJIs. Patients who underwent THA or TKA between January 2016 and December 2017 were identified. Only patients with complete follow-up data for at least 90 days after surgery, based on insurance records, were eligible for inclusion. The primary outcome was PJI within 90 days, defined as the presence of an ICD-10-Clinical Modification (CM) diagnosis code for PJI recorded in claims within 90 days of the index THA or TKA procedure. A total of 13,442 patients who underwent THA and 40,245 patients who underwent TKA were included. The PJI rate within 90 days was 0.61% (82 of 13,442) for THA and 0.58% (232 of 40,245) for TKA. Cox regression analyses were used to estimate associations between potential demographic and clinical factors and the risk of PJI within 90 days. After adjusting for age, sex, diabetes, and other clinically relevant factors, we found that the adjusted HR (aHR) for PJI within 90 days after THA was higher among patients who were male (aHR 2.49 [95% confidence interval (CI) 1.38 to 4.48]; p < 0.01), had a longer length of stay (aHR 1.06 [95% CI 1.04 to 1.09]; p < 0.01), had diabetes mellitus (aHR 3.72 [95% CI 2.21 to 6.26]; p < 0.01), had hepatitis B infection (aHR 2.44 [95% CI 1.11 to 5.36]; p = 0.03), and had hepatitis C infection (aHR 2.76 [95% CI 1.14 to 6.66]; p = 0.02). A preoperative diagnosis of osteoarthritis or avascular necrosis of the femoral head was associated with a reduced risk of PJI within 90 days after THA, compared with other etiologies (aHR 0.48 [95% CI 0.27 to 0.87] and aHR 0.43 [95% CI 0.22 to 0.84]; both p = 0.01). The aHR for PJI within 90 days after TKA was higher for patients who were younger than 65 years (aHR 1.57 [95% CI 1.18 to 2.08]; p < 0.01), male (aHR 2.05 [95% CI 1.55 to 2.71]; p < 0.01), had a longer length of stay (aHR 1.09 [95% CI 1.08 to 1.11]; p < 0.01), had osteoporosis (aHR 1.44 [95% CI 1.08 to 1.92]; p = 0.01), and had chronic kidney disease (aHR 1.50 [95% CI 1.06 to 2.11]; p = 0.02). The aHR was lower for patients who had bilateral TKA (aHR 0.31 [95% CI 0.12 to 0.84]; p = 0.02) compared with those who had unilateral TKA only. Male sex, diabetes, hepatitis C, osteoporosis, chronic kidney disease, and younger age after TKA were associated with a higher risk of PJI within 90 days. The findings indicate that surgeons may enhance perioperative infection prevention efforts in these high-risk patients by optimizing glycemic control, improving perioperative medical management, minimizing surgical time and blood loss when possible, and ensuring rigorous postoperative wound surveillance. Future large-scale observational studies are needed to refine individualized risk prediction and assess the effectiveness of targeted preventive strategies in real-world clinical practice. Level III, therapeutic study.

Publicações recentes

The role of gender in patients with developmental dysplasia of the hip treated with closed reduction and spica cast immobilization: does it affect prognosis?

J Pediatr Orthop B2026 Mar 16

Proportion of Avascular Necrosis of Femoral Head in Coronavirus Disease 19 Patients.

Ann Afr Med2026 Jan 1

Effects of PRP injection combined with intersecting femoral head decompression versus combined with multiple core decompression in the treatment of avascular necrosis of femoral head-a single-center retrospective cohort study.

BMC Musculoskelet Disord2025 May 2

Hip arthroscope-assisted percutaneous reduction and fixation of displaced subcapital femoral neck fracture.

Front Surg2025

Clinical analysis of Ganz approach in the treatment of Pipkin type IV fracture: a retrospective review.

BMC Musculoskelet Disord2025 Apr 8

Ver todas no PubMed

📚 EuropePMCmostrando 120

International journal of molecular sciences

Familial Cases of Legg-Calvé-Perthes Disease-Hemostatic and Molecular Markers.

Journal of orthopaedic case reports

Total Hip Arthroplasty in Lubumbashi (DR Congo), Outcomes in a Resource-Limited Setting.

Severe Radiographic Legg-Calvé-Perthes Disease With Favorable Long-Term Functional Outcomes Following Conservative Management: A Case Report.

Pain medicine case reports

A Novel Multisite Peripheral Nerve Stimulation Approach for Chronic Hip Pain in Avascular Necrosis: A Case Report.

Exploring the alteration of gut microbiota in the rats with steroid-induce osteonecrosis of the femoral head.

BMC microbiology

Silent Avascular Necrosis of the Femoral Head in Severe Hemophilia A: A Case Report.

Factors That Increase the Risk of Prosthetic Joint Infection Within 90 Days After THA and TKA: A Nationwide Population-based Study.

Clinical Implications of HbD-Punjab and HbS co-Inheritance - A Rare Case in South India.

Hemoglobin

Incidence and Risk Factors for Nontraumatic Osteonecrosis of the Femoral Head in Kidney Transplant Recipients: A Comparison of Two Eras (1985-2000 and 2001-2024).

Clinical transplantation

Decreased serum and local GPX4 and SLC7A11 expression correlates with disease severity in non-traumatic osteonecrosis of the femoral head.

BMC musculoskeletal disorders

A rare cause for osteonecrosis of femoral head and peripheral nerve damage of a child with depression.

Targeted transarterial embolization of the femoral head: development of a minimally invasive approach to model Legg-Calvé-Perthes disease in piglets.

PloS one

Microcytosis Merits Evaluation: A Case Report of Hemoglobin S With Hereditary Persistence of Fetal Hemoglobin (HbS-HPFH Syndrome).

International journal of surgery case reports

Neglected obturator hip dislocation with associated avascular necrosis of the femoral head in adolescent, a rare case report.

Orthopadie (Heidelberg, Germany)

Thrombophilia, hypofibrinolysis and osteonecrosis.

Healing beyond bone: a qualitative study of the core decompression experience of physically active patients with stage II hip avascular necrosis.

Longitudinal Improvement of Quality of Life in Children With Legg-Calve-Perthes Disease Treated With Proximal Femoral Varus Osteotomy.

BMC musculoskeletal disorders

Clinical outcomes of open reduction and internal fixation combined with sartorius muscle iliac bone graft transplantation for displaced femoral neck fractures in middle-aged and young adults: a retrospective analysis of 24 cases.

Inhibition of sympathetic tone via hypothalamic descending pathway propagates glucocorticoid-induced endothelial impairment and osteonecrosis of the femoral head.

Bone research

Low Rate of AVN and Complications in Unstable SCFE With Epiphyseal-metaphyseal Discontinuity After Treatment With a Modified Dunn Procedure.

Indian journal of orthopaedics

Augmentation of Autologous Platelet-Rich Plasma in Hip Salvage in Stages I and II of Avascular Necrosis: Randomized Blinded Trial Comparing 3 Surgical Techniques in 82 Patients.

How Is Variability in Femoral and Acetabular Version Associated With Presentation Among Young Adults With Hip Pain?

Advances in the Pathogenesis of Steroid-Associated Osteonecrosis of the Femoral Head.

Biomolecules

International journal of surgery case reports

Brucellosis-induced bilateral avascular necrosis of the hip joints in a middle-aged Iranian woman with refractory intolerance to medications: A case report.

Clinical consensus recommendations for the non-surgical treatment of children with Perthes' disease in the UK.

The bone & joint journal

Predictors of Persistent Limp Following Proximal Femoral Varus Osteotomy for Perthes Disease.

Pathogenic Gene Variants Identified in Patients Presenting With Perthes or Perthes-like Hip Disorder.

Hip international : the journal of clinical and experimental research on hip pathology and therapy

Incidence of avascular necrosis of native femur following hip transposition surgery for periacetabular malignancies: a single-centre experience.

Elucidating the role of the GC/GR/GLUT1 axis in steroid-induced osteonecrosis of the femoral head: A proteomic approach.

Bone

Insight into Steroid-Induced ONFH: The Molecular Mechanism and Function of Epigenetic Modification in Mesenchymal Stem Cells.

Biomolecules

Orthopedic research and reviews

Management of Garden-I and II Femoral Neck Fractures: Perspectives on Primary Arthroplasty.

Is Subcapital Realignment for Slipped Capital Femoral Epiphysis a Reproducible Technique? Midterm Results.

Naunyn-Schmiedeberg's archives of pharmacology

EGFL6 activates the ERK signaling to improve angiogenesis and osteogenesis of BMSCs in patients with steroid-induced osteonecrosis of the femoral head.

Bilateral Avascular Necrosis of the Femoral Heads Secondary to Familial Hyperlipidemia.

"Waiting for the best day of your life". A qualitative interview study of patients' and clinicians' experiences of Perthes' disease.

Bone & joint open

The quality of online information on Legg-Calvé-Perthes disease: can we do better?

CORR Insights®: Does Adjunction of Autologous Osteoblastic Cells Improve the Results of Core Decompression in Early-stage Femoral Head Osteonecrosis? A Double-blind, Randomized Trial.

Molecular biology reports

Runx2 overexpression promotes bone repair of osteonecrosis of the femoral head (ONFH).

Orthopaedic journal of sports medicine

Puncture Capsulotomy Technique for Hip Arthroscopy: Midterm Functional Outcomes.

CORR Insights®: Does Flexion Varus Osteotomy Improve Radiographic Findings Compared With Patients Treated in a Brace for Late-onset Legg-Calvé-Perthes Disease?

CORR Insights®: Is There an Association Between Femoral Head Collapse and Acetabular Coverage in Patients With Osteonecrosis?

Does Flexion Varus Osteotomy Improve Radiographic Findings Compared With Patients Treated in a Brace for Late-onset Legg-Calvé-Perthes Disease?

Revisiting prediction of collapse in hip osteonecrosis with artificial intelligence and machine learning: a new approach for quantifying and ranking the contribution and association of factors for collapse.

Development of acetabular retroversion in LCPD hips-an observational radiographic study from early stage to healing.

mRNA expression profiling of the cancellous bone in patients with idiopathic osteonecrosis of the femoral head by whole-transcriptome sequencing.

Management of Patients With Legg-Calvé-Perthes Disease at a Single Center in Jeddah, Saudi Arabia.

Acta orthopaedica et traumatologica turcica

Radiographical and clinical results of a new conservative treatment algorithm in Legg-Calvè-Perthes disease: A retrospective study.

Medecine tropicale et sante internationale

[Hip necrosis. A severe complication after intragluteal injection of quinine salt in Bangui, Central African Republic].

Journal of pediatric orthopedics. Part B

Quality of YouTube videos for three common pediatric hip conditions: developmental hip dysplasia, slipped capital femoral epiphysis and Legg-Calve-Perthes disease.

Comparative effectiveness of treatment modalities in severe Legg‑Calvé‑Perthes disease: Systematic review and network meta‑analysis of observational studies.

CORR Insights®: Moderate Weightbearing Restrictions Are Associated with Worse Depressive Symptoms and Anxiety in Children Aged 5 to 7 Years with Perthes Disease.

Orthopaedic journal of sports medicine

Safety of Intra-articular Hip Corticosteroid Injections: A Matched-Pair Cohort Study.

Progressive lateralization and constant hip geometry in children with DDH, NDH, and LCPD following hip reconstructive surgery: a cohort study of 73 patients with a mean follow-up of 4.9 years.

Moderate Weightbearing Restrictions Are Associated with Worse Depressive Symptoms and Anxiety in Children Aged 5 to 7 Years with Perthes Disease.

The Iowa orthopaedic journal

Ligamentum Teres Transfer During Medial Open Reduction in Patients with Developmental Dysplasia of the Hip.

A Modeling Study of a Patient-specific Safe Zone for THA: Calculation, Validation, and Key Factors Based on Standing and Sitting Sagittal Pelvic Tilt.

British journal of sports medicine

Primary cam morphology; bump, burden or bog-standard? A concept analysis.

Mapping and Crosswalk of the Oxford Hip Score and Different Versions of the Hip Disability and Osteoarthritis Outcome Score.

A novel mutation of COL2A1 in a large Chinese family with avascular necrosis of the femoral head.

BMC medical genomics

Puerarin facilitates osteogenesis in steroid-induced necrosis of rabbit femoral head and osteogenesis of steroid-induced osteocytes via miR-34a upregulation.

Cytokine

CORR Insights®: Weightbearing and Activity Restriction Treatments and Quality of Life in Patients with Perthes Disease.

Annals of the New York Academy of Sciences

Resveratrol prevents steroid-induced osteonecrosis of the femoral head via miR-146a modulation.

Results after spica cast immobilization following hip reconstruction in 95 cases: is there a need for alternative techniques?

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde

Namaqualand hip dysplasia in South Africa: The molecular determinant elucidated.

Journal of family medicine and primary care

Clinical profile of osteonecrosis in systemic lupus erythematosus - Experience from a tertiary care centre in South India.

The Journal of the American Academy of Orthopaedic Surgeons

Demographics and Clinical Presentation of Early-Stage Legg-Calvé-Perthes Disease: A Prospective, Multicenter, International Study.

CORR Insights®: High Pelvic Incidence Is Associated with Disease Progression in Nontraumatic Osteonecrosis of the Femoral Head.

High Pelvic Incidence Is Associated with Disease Progression in Nontraumatic Osteonecrosis of the Femoral Head.

Annals of palliative medicine

H subtype vascular endothelial cells in human femoral head: an experimental verification.

Genetic testing and molecular biomarkers

Association Between Genetic Polymorphisms of CR2 Gene and the Risk of Steroid-Induced Osteonecrosis of the Femoral Head in the Chinese Han Male Population.

Tübingen hip flexion splints for developmental dysplasia of the hip in infants aged 0-6 months.

BMC pediatrics

The outcomes of Perthes' disease.

The bone & joint journal

Long-term Anticoagulation Prevents Progression of Stages I and II Primary Osteonecrosis of the Hip in Patients With Familial Thrombophilia.

Orthopedics

BioMed research international

The Use of Platelet-Rich Plasma for the Treatment of Osteonecrosis of the Femoral Head: A Systematic Review.

Osteonecrosis of the femoral head due to brucellosis: a case report.

BMC infectious diseases

Journal of pediatric orthopedics. Part B

Influence of passive smoking on the onset of Legg-Calvè-Perthes disease: a systematic review and meta-analysis.

The Cochrane database of systematic reviews

Probiotics for maintenance of remission in ulcerative colitis.

Evaluating the association between avascular necrosis of femoral head and oral corticosteroids use in Taiwan.

Did Osteoblastic Cell Therapy Improve the Prognosis of Pre-fracture Osteonecrosis of the Femoral Head? A Randomized, Controlled Trial.

BMC musculoskeletal disorders

Supercapsular percutaneously-assisted total hip (SuperPath) versus posterolateral total hip arthroplasty in bilateral osteonecrosis of the femoral head: a pilot clinical trial.

Does An Augmented Reality-based Portable Navigation System Improve the Accuracy of Acetabular Component Orientation During THA? A Randomized Controlled Trial.

CORR Insights®: Isolated Trochanteric Descent and Greater Trochanteric Apophyseodesis Are Not Effective in the Treatment of Post-Perthes Deformity.

Free vascularized iliac bone flap based on deep circumflex iliac vessels graft for the treatment of osteonecrosis of femoral head.

Isolated Trochanteric Descent and Greater Trochanteric Apophyseodesis Are Not Effective in the Treatment of Post-Perthes Deformity.

Developmental dysplasia of the hip: update of management.

EFORT open reviews

5-Azacytidine and trichostatin A enhance the osteogenic differentiation of bone marrow mesenchymal stem cells isolated from steroid-induced avascular necrosis of the femoral head in rabbit.

Journal of biosciences

Canadian journal of surgery. Journal canadien de chirurgie

Long-term outcomes of total hip arthroplasty in patients younger than 55 years: a systematic review of the contemporary literature.

Relationship of α2-Macroglobulin with Steroid-Induced Femoral Head Necrosis: A Chinese Population-Based Association Study in Southeast China.

Orthopaedic surgery

Cell biology international

OGR1 mediates the inhibitory effects of acidic environment on proliferation and angiogenesis of endothelial progenitor cells.

Does Extracorporeal Irradiation and Reimplantation After Acetabular Resections Result in Adequate Hip Function? A Preliminary Report.

Real-World Database Examining the Association Between Avascular Necrosis of the Femoral Head and Diabetes in Taiwan.

Diabetes care

CORR Insights®: What are the Demographics and Epidemiology of Legg-Calvé-Perthes Disease in a Large Southern California Integrated Health System?

Patient safety in surgery

Predictors of femoral shortening for pediatric developmental hip dysplasia surgery: an observational study in 435 patients.

The clinical application of a novel method of internal fixation for femoral neck fractures-dynamic locking compression system.

Clinical value of 3D printing guide plate in core decompression plus porous bioceramics rod placement for the treatment of early osteonecrosis of the femoral head.

The role of autophagy in steroid necrosis of the femoral head: a comprehensive research review.

Journal of surgical orthopaedic advances

Pediatric Orthopaedic Consults From Chiropractic Care.

Molecular medicine reports

COL2A1 mutation (c.3508G>A) leads to avascular necrosis of the femoral head in a Chinese family: A case report.

Radiological analysis of cystic lesion in osteonecrosis of the femoral head.

Is Legg-Calvé-Perthes Disease a Local Manifestation of a Systemic Condition?

Health technology assessment (Winchester, England)

Timing of surgical intervention for developmental dysplasia of the hip: a randomised controlled trial (Hip 'Op).

The Israel Medical Association journal : IMAJ

Exploring the Association between Legg-Calvé-Perthes Disease and Attention Deficit Hyperactivity Disorder in Children.

The use of anticoagulants for prevention and treatment of osteonecrosis of the femoral head: A systematic review.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

Hyper-immunoglobulin E-like syndrome in a patient with multiple genetic mutations.

American journal of medical genetics. Part A

Two cases of Legg-Perthes and intellectual disability in Tricho-Rhino-Phalangeal syndrome type 1 associated with novel TRPS1 mutations.

Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology

Management and radiographic outcomes of femoral head fractures.

Mediators of inflammation

Hip Osteonecrosis Is Associated with Increased Plasma IL-33 Level.

Molecular medicine reports

Genome-wide association scans for idiopathic osteonecrosis of the femoral head in a Korean population.

Single-nucleotide polymorphisms of MMP2 in MMP/TIMP pathways associated with the risk of alcohol-induced osteonecrosis of the femoral head in Chinese males: A case-control study.

Bone marrow transplantation

Focused extracorporeal shock wave for osteonecrosis of the femoral head with leukemia after allo-HSCT: a case series.

Comparative analysis of gene expression profiles of hip articular cartilage between non-traumatic necrosis and osteoarthritis.

Gene

Journal of medical genetics

Gain-of-function mutation in TRPV4 identified in patients with osteonecrosis of the femoral head.

Arthritis research & therapy

Comparative analysis of gene expression profiles in normal hip human cartilage and cartilage from patients with necrosis of the femoral head.

A Twin Study of Perthes Disease.

Pediatrics

Annals of Ibadan postgraduate medicine

ADDICTION OR PSEUDOADDICTION IN SICKLE CELL DISEASE PATIENTS: TIME TO DECIDE - A CASE SERIES.

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

Imaging and histopathological aspects in aseptic osteonecrosis of the femoral head.

Prevalence of Nontraumatic Osteonecrosis of the Femoral Head and its Associated Risk Factors in the Chinese Population: Results from a Nationally Representative Survey.

Chinese medical journal

Pitfalls in Diagnosing Neuraminidase Deficiency: Psychosomatics and Normal Sialic Acid Excretion.

JIMD reports

Osteonecrosis After Femoral Neck Fractures in Children and Adolescents: Analysis of Risk Factors.

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[Buschke-Ollendorff syndrome in two generations imitated Calvé-Legg-Perthes disease].

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Doenças relacionadas

Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico

Ordenadas pelo número de sintomas em comum.

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Displasia epifisária múltipla, tipo 1

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