Doença crônica e autoimune da pele que se manifesta com erupção cutânea vermelha e descamativa, mais frequentemente encontrada no rosto, orelhas e couro cabeludo; essas lesões geralmente levam a cicatrizes permanentes e despigmentação. Os pacientes podem apresentar lesões com ou sem outros sintomas ou anticorpos sugestivos de lúpus eritematoso sistêmico (LES).
Introdução
O que você precisa saber de cara
O **lúpus eritematoso discoide** é uma doença autoimune e de longa duração que atinge a pele, provocando manchas avermelhadas e descamativas no rosto, orelhas e couro cabeludo. Com o passar do tempo, as lesões podem causar cicatrizes permanentes, áreas esbranquiçadas e queda definitiva de cabelo nas regiões inflamadas. O diagnóstico é estabelecido principalmente pela avaliação médica das manchas e pelo resultado de biópsia cutânea com teste de banda lúpica positivo. No Brasil, o Ministério da Saúde disponibiliza o PCDT de lúpus eritematoso sistêmico como documento relacionado, e o SUS entrega opções farmacológicas como azatioprina e ciclosporina.
Doença crônica e autoimune da pele que se manifesta com erupção cutânea vermelha e descamativa, mais frequentemente encontrada no rosto, orelhas e couro cabeludo; essas lesões geralmente levam a cicatrizes permanentes e despigmentação. Os pacientes podem apresentar lesões com ou sem outros sintomas ou anticorpos sugestivos de lúpus eritematoso sistêmico (LES).
Tem tratamento?
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Entender a doença
Do básico ao detalhe, leia no seu ritmo
Preparando trilha educativa...
Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 10 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Genética e causas
O que está alterado no DNA e como passa nas famílias
Nenhum gene associado encontrado
Os dados genéticos desta condição ainda estão sendo catalogados.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Lúpus eritematoso discoide
Selecione um estado ou use sua localização para ver resultados.
Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
Com ensaio aberto em 21 países. O ponto verde marca onde há vaga agora.
🟢 Recrutando agora
4 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.
Outros ensaios clínicos
41 ensaios clínicos encontrados, 11 ativos.
Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 610
Comorbidities in Discoid Lupus: A Systematic Review and Meta-analysis of Prevalence and Association.
Discoid lupus erythematosus (DLE) is a chronic inflammatory scarring alopecia that may be accompanied by a broad range of systemic and extracutaneous comorbidities. However, the prevalence and magnitude of these associations have not been comprehensively quantified. Our objective was to systematically evaluate the prevalence and associated risk of comorbidities in patients with discoid lupus erythematosus. We conducted a systematic review and random-effects meta-analysis in accordance with PRISMA 2020 guidelines, prospectively registered in PROSPERO (CRD420250656067). MEDLINE and Embase were searched from inception to June 2025. Observational studies reporting comorbidities in patients with DLE were included. Pooled prevalence estimates and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using random-effects models. Between-study heterogeneity was assessed using the I2 statistic. Sensitivity analyses excluding small studies (n < 50) were performed for prevalence outcomes, whereas the robustness of association analyses was assessed qualitatively owing to the limited number of contributing studies. Methodological quality was evaluated using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist. In total, 25 studies were included. Pooled prevalence estimates indicated a high frequency of systemic lupus erythematosus (SLE) (22.0%), hypertension (24.3%), depression (38.8%), and hypothyroidism (12.4%) among patients with DLE. Sensitivity analyses showed stable prevalence estimates for SLE and hypertension, with moderate variability for hypothyroidism and depression. Meta-analyses of case-control studies demonstrated significant associations between DLE and cardiovascular disease (OR 3.85, 95% CI 1.67-8.88), hypothyroidism (OR 2.55, 95% CI 1.79-3.61), hypertension (OR 2.22, 95% CI 1.91-2.58), depression (OR 2.21, 95% CI 1.71-2.85), and anxiety (OR 2.40, 95% CI 1.40-4.11). Associations with type 2 diabetes were more modest, while smoking was not significantly associated. Most association analyses were based on a limited number of studies. Patients with discoid lupus erythematosus exhibit a substantial burden of systemic, cardiometabolic, endocrine, and psychiatric comorbidities. While prevalence estimates were generally consistent, associations should be interpreted cautiously owing to limited available evidence. These findings highlight the importance of comprehensive clinical assessment and multidisciplinary management of patients with DLE. The study protocol was prospectively registered in PROSPERO (CRD420250656067).
Implications of Dermatologic Disorders in Facial Cosmetic Surgery: A Systematic Review.
Invasive and minimally invasive cosmetic procedures in patients with autoimmune or inflammatory skin disorders can carry an increased risk of surgical site infection, disease exacerbation, atrophic/hypertrophic scarring, or suboptimal cosmetic results. As facial procedures continue to rise in popularity, increasing complications are being reported in association with underlying dermatologic disease. In this review, we aim to bring attention to these dermatologic conditions and the potential challenges that they pose to the facial plastic surgeon. A comprehensive literature search was conducted across PubMed, Embase, and MEDLINE for articles published before January 2025 describing one or more patients with complications following facial or scalp procedures relating to a pre-existing or underlying dermatologic disorder or systemic condition with dermatologic manifestations. Articles were screened according to PRISMA guidelines, and data extraction included dermatologic disease diagnosis and severity, facial procedure performed, perioperative or postoperative complications, and resolution/treatment. Our search criteria identified 2452 articles; 53 articles met the inclusion criteria. In a total of 469 patients with pre-existing dermatologic conditions, mild-severe complications were reported after blepharoplasty (41/469, 8.7%), rhinoplasty (254/469, 54.2%), rhytidectomy (25/469, 5.3%), hair transplantation (37/469, 7.9%), cosmetic injections (35/469, 7.5%), lasers (15/469, 3.2%), and microneedling (50/469, 10.7%). Dermatologic disorders included acne, atopic dermatitis, frontal fibrosing alopecia, lichen planopilaris, rosacea, and vitiligo; systemic conditions with dermatologic manifestations included Ehlers-Danlos syndrome, sarcoidosis, scleroderma, and systemic or discoid lupus erythematosus. Complications ranged from mild postoperative disease exacerbation to severe hypertrophic scarring, ulcerations, and wound healing defects. The existing literature, while limited to case reports and small case series, demonstrates potential risks following facial procedures in patients with dermatologic disorders. This review highlights the importance of consideration of dermatologic disease in facial surgery planning and decision-making and summarizes effective strategies to minimize any potential risk.
Treatment of discoid lupus erythematosus with crisaborole.
Discoid lupus erythematosus (DLE) is a chronic autoimmune skin disorder that primarily affects sun-exposed areas and may lead to permanent scarring and dyspigmentation if inadequately treated. Therapeutic options for DLE remain limited, and long-term use of topical corticosteroids or calcineurin inhibitors is often constrained by adverse effects, particularly on facial skin. This report aims to describe the clinical response of facial DLE to topical crisaborole treatment. We report the case of a 20-year-old woman with a 7-year history of a persistent erythematous plaque on the nose, previously misdiagnosed and refractory to multiple treatments, including systemic antimalarials and topical agents. Histopathological examination and direct immunofluorescence findings supported a diagnosis of DLE without systemic involvement. The patient was treated with topical crisaborole 2% ointment once daily in combination with hydroxychloroquine. Marked clinical improvement was observed after two months of treatment. Sustained remission was maintained during a seven-month follow-up period with continued crisaborole use and dose reduction of hydroxychloroquine, without recurrence or adverse effects. Crisaborole, a topical phosphodiesterase-4 inhibitor approved for atopic dermatitis, may represent a well-tolerated nonsteroidal therapeutic option for facial DLE, particularly in patients who are unresponsive to or intolerant of conventional treatments. Further studies are needed to clarify its efficacy and long-term safety in DLE.
Association of Autoimmune Diseases With Pancreatic Cancer: A Nationwide Follow-Up Study From Sweden.
The incidence of pancreatic cancer (PC) and autoimmune diseases (ADs) has been increasing worldwide. While certain associations between specific ADs, such as pancreatitis, and PC have long been well confirmed, population-focused research investigating the broader spectrum of ADs and their relationship with PC risk remains limited. We implemented a cohort study based on population data to analyze the relationships between ADs and PC susceptibility. Diagnostic information on 43 ADs was obtained from the Swedish Inpatient Register (1964-2018), while cancer incidence and mortality data were sourced from the National Cancer Registry and Cause of Death Register starting in 1997. Relative cancer risks were quantified using standardized incidence ratios (SIRs) and standardized mortality ratios (SMRs). Within the study's total population of 16.4 million, 1.1 million cases of ADs were identified, and 3257 patients were later diagnosed with PC accounting for 5.42% of all cancer cases in the cohort. The SIRs for PC in patients with ADs were 1.24 (men) and 1.19 (women); 12 ADs were positively correlated with the incidence of PC. The SMRs for PC in patients with ADs were 1.28 (men) and 1.22 (women); 15 ADs were positively correlated with PC mortality. When the follow-up time was less than 1 year, the overall risk of PC in patients with ADs was 3.88; over 10 years, the risk reached 1.12. We have newly discovered the relationship between several ADs and the risk of PC incidence and mortality, including discoid lupus erythematosus, lupoid hepatitis, giant-cell arteritis, and rheumatic fever. The results of this study back the notion that ADs may have a role in promoting the onset of PC.
Pigmented Allergic Salute Sign in an Adult With Dark Skin: Clinical and Dermoscopic Features.
Post-inflammatory hyperpigmentation due to chronic mechanical friction is well recognized in individuals with darker skin types, yet the pigmented variant of the allergic salute sign remains rarely documented. We report a 40-year-old woman with a persistent transverse hyperpigmented band over the nasal dorsum, associated with long-standing allergic rhinitis and recurrent conjunctivitis. She described habitual upward rubbing of the nose due to intense pruritus. Clinical examination revealed a sharply demarcated dark linear band above the nasal tip. Dermoscopy demonstrated a homogeneous dark pseudo-network with prominent follicular openings, consistent with post-inflammatory hyperpigmentation in Fitzpatrick phototype VI skin. Awareness of this presentation is essential to differentiate it from lichen planus pigmentosus or discoid lupus erythematosus. Management focuses on controlling allergic rhinitis, minimizing mechanical friction, and cautious use of depigmenting therapies. This case highlights the pigmented allergic salute sign as a distinctive marker of chronic allergic disease in patients with dark skin. Lupus erythematosus is a multisystem disorder that predominantly affects the skin. There are many types of lupus, including systemic lupus erythematosus (SLE), drug-induced lupus erythematosus, neonatal lupus erythematosus, and cutaneous lupus erythematosus. The most common types of cutaneous lupus erythematosus include acute cutaneous lupus erythematosus, subacute cutaneous lupus erythematosus, and chronic cutaneous lupus erythematosus; discoid lupus erythematosus is a subtype of chronic cutaneous lupus erythematosus. Dr James Gilliam described the most commonly used classification of cutaneous lesions in lupus erythematosus. He distinguished lesions as either specific or nonspecific, based on the presence of interface dermatitis on histopathologic examination. Within the category of specific cutaneous lesions, he subdivided these into acute cutaneous lupus erythematosus, subacute cutaneous lupus erythematosus, and chronic cutaneous erythematosus. Discoid lupus erythematosus is the most common subset of chronic cutaneous lupus erythematosus. Patients may or may not report photosensitivity, but lesions are frequently photodistributed and often exhibit secondary atrophy or scarring. Most patients with discoid lupus erythematosus do not have significant systemic disease. Discoid lupus erythematosus can also occur as a manifestation of SLE in approximately 20% of patients. Other less common variants of chronic cutaneous lupus erythematosus include hypertrophic lupus erythematosus, tumid lupus erythematosus, lupus erythematosus panniculitis (also known as lupus profundus), chilblain lupus erythematosus, oral discoid lupus erythematosus, and discoid lupus erythematosus lesions on the palms and soles.
Publicações recentes
Hair follicle immune privilege in autoimmune and immune-mediated alopecias: paths toward reestablishing immune tolerance.
[Successful management of chronic discoid lupus erythematosus with anifrolumab].
Targeting TYK2 in Cutaneous Autoimmunity: Deucravacitinib-Induced Remission of Discoid Lupus and Psoriasis with Supportive Confocal Microscopy Findings.
Photosensitive symmetric papules of the nasal alae.
Predictors of severity of sequelae in discoid lupus erythematosus: A longitudinal cohort study.
📚 EuropePMC1.062 artigos no totalmostrando 198
Comorbidities in Discoid Lupus: A Systematic Review and Meta-analysis of Prevalence and Association.
Dermatology and therapyImplications of Dermatologic Disorders in Facial Cosmetic Surgery: A Systematic Review.
Annals of plastic surgeryCharacteristics, Management, and Outcomes of Cutaneous Malignancies Arising Within Discoid Lupus Erythematosus: A Systematic Review.
Journal of cutaneous medicine and surgeryTreatment of discoid lupus erythematosus with crisaborole.
The Journal of dermatological treatmentCarrier of a pathogenic LAMB3 variant: Exploring the interface of genetic skin fragility and cutaneous autoimmunity.
JAAD case reportsAssociation of Autoimmune Diseases With Pancreatic Cancer: A Nationwide Follow-Up Study From Sweden.
Cancer medicinePigmented Allergic Salute Sign in an Adult With Dark Skin: Clinical and Dermoscopic Features.
CureusA Diagnostic Pitfall: Lupus Mastitis Presenting Before Diagnosis of Systemic Lupus Erythematosus.
Case reports in rheumatologyLupus Erythematosus Panniculitis Patients With Overlying Discoid Lupus Erythematosus Have Higher Rates of Head and Neck Involvement Than Those Without.
The Journal of dermatologyDermoscopy of Lichen Planus Follicularis Tumidus: A Case Report With Pattern Analysis and Literature Review.
Clinical case reportsIn vivo differentiation of scarring alopecia using line-field confocal optical coherence tomography: a pilot study.
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDGGeneralized verrucous discoid lupus erythematosus.
Journal of the European Academy of Dermatology and Venereology : JEADVA Case Report of Discoid Lupus Erythematosus Mimicking Skin Infection.
Reports (MDPI)Rapid clinical response in refractory discoid lupus erythematosus treated with anifrolumab.
Anais brasileiros de dermatologiaLine Field Confocal Optical Coherence Tomography (LC-OCT) Features of Primary Cicatricial Alopecias.
International journal of dermatologyCheilitis: a comprehensive review and a new clinical classification proposal. Part 1: Isolated cheilitis.
Italian journal of dermatology and venereologyXanthomatous Discoid Lupus Erythematosus: An Unusual Histopathological Variant and Review of Reported Cases.
CureusA Rare Case of Coexistence: Discoid Lupus Erythematosus and Sturge-Weber Syndrome.
Clinical case reportsA Unique Case of Nodular Cutaneous Lupus Mucinosis With Discoid Lupus Erythematosus-Like Changes in a Patient With Systemic Lupus Erythematosus and Sjögren Syndrome.
The Journal of dermatologyCheilitis: a comprehensive review and a new clinical classification proposal. Part 2: Cheilitis associated with dermatological diseases, systemic diseases, or drug reactions.
Italian journal of dermatology and venereologyDiscoid Lupus Erythematosus: A Comparative Evaluation Between Line-Field Confocal Optical Coherence Tomography and Histology in a Multicenter Cross-Sectional Study.
Experimental dermatologyA Sonidegib Experience in the Treatment of Basal Cell Carcinoma with Systemic Lupus Erythematosus: A Case Report.
Clinical, cosmetic and investigational dermatologyRare coexistence of generalized pustular psoriasis and discoid lupus erythematosus with worsening of lupus lesions after bimekizumab therapy: a case report.
European journal of dermatology : EJDTrichoscopic Differentiation in Alopecia: Retrospective Case Series Comparing Lichen Planopilaris, Discoid Lupus Erythematosus, and Alopecia Areata.
JMIR dermatologyImplications of Podoplanin Overexpression in the Malignant Transformation of Oral Potentially Malignant Disorders: A Systematic Review and Meta-Analysis.
CancersIdentification of T cell stress response state (TSTR) and key genes related to T cells in discoid lupus erythematosus.
Scientific reportsDiscoid lupus erythematosus and its progression to systemic lupus erythematosus across age groups: a systematic review.
Journal of medicine and lifeTopical Cyclosporine 5% in Pentravan for Refractory Discoid Lupus Erythematosus: Clinical Remission in a 15 Patients Case Series.
International journal of dermatologyKoebner Phenomenon Induced by Eyeglasses in a Patient With Discoid Lupus Erythematosus.
Case reports in dermatological medicineErbium-doped nonablative fractional laser therapy for postinflammatory hyperpigmentation and atrophic scarring due to discoid lupus erythematosus in a patient with systemic lupus erythematosus.
JAAD case reportsCrosstalk Between Keratinocytes and T Cells in Ulcerative Oral Mucosal Diseases: Mechanisms of Epithelial Dysfunction and Therapeutic Perspectives.
Journal of inflammation researchReview of Promising Off-Label Use of Deucravacitinib.
International journal of molecular sciencesA systematic review of procedural modalities in the treatment of lichen planopilaris, frontal fibrosing alopecia, and discoid lupus erythematosus.
Lasers in medical scienceDyspigmentation and scarring in cutaneous lupus erythematosus.
Lupus science & medicineLong-Term Risk of Dermatoses Following Sulfur Mustard Exposure: A Retrospective Cohort Study.
International journal of dermatologyUnilateral discoid lupus erythematosus: two atypical cases with distinct presentations.
Dermatology online journalTreatment of Cutaneous Lupus Erythematosus: An Evidence-Based Review.
Dermatology (Basel, Switzerland)Micronutrient levels and thyroid functions in scarring alopecias: Do they play a role in disease pathogenesis?
Cutaneous and ocular toxicologyTargeting JAK/STAT signaling: ruxolitinib cream in the management of concurrent vitiligo and discoid lupus erythematosus.
Dermatology reportsEyelid Involvement as a Standalone Ophthalmological Finding of Lupus.
Ophthalmic plastic and reconstructive surgeryComparison of the Efficacy of Intralesional Ascorbic Acid Mesotherapy and Intralesional Tranexamic Acid in Treating Melasma in the Skin of Colour Population.
CureusWolf and the Dagger: A Rare Overlap.
CureusIsotopic Responses Following Herpes Zoster.
Journal of drugs in dermatology : JDDA Rare Case of Lichen Planus/Discoid Lupus Erythematosus Overlap Syndrome and Its Successful Treatment.
Clinical case reportsDiscoid lupus erythematosus with cornoid lamellation.
European journal of dermatology : EJDA Single Centre Cross-Sectional Observational Study on Dermatoscopy of Oral Mucosal Disorders and Histopathological Correlation in Tertiary Care Centre from Central India.
Indian journal of dermatologyDiscoid Lupus Flare with Chondritis Triggered by Eaton Fire Case Report.
Current rheumatology reviewsParry-Romberg Syndrome with Localized Plaque Morphea and Localized Discoid Lupus Erythematosus: A Case Report of a Rare Overlap.
Indian dermatology online journalRecognizing ophiasis pattern in discoid lupus: a rare diagnostic challenge.
Dermatology reportsTrichopathology of Cicatricial Alopecia.
International journal of trichologyTrends and collaborations in discoid lupus erythematosus research: a bibliometric analysis from 2010 to 2024.
Frontiers in medicine[Recent advances in the relationship and mechanistic study of hyperglycemia and oral potentially malignant disorders].
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatologyDemodex Infestation in Discoid Lupus Erythematosus: A Histopathologic Study.
The American Journal of dermatopathologySuccessful use of anifrolumab in refractory cutaneous lupus erythematosus with systemic lupus erythematosus: A case report.
SAGE open medical case reportsA case of vitiligo secondary to discoid lupus erythematosus treated with tofacitinib.
MedicineSkin Biopsy for Diagnosing Discoid Lupus Erythematosus.
Journal of visualized experiments : JoVEC1q monogenic lupus: a case series and review.
Rheumatology advances in practiceImmunohistochemical Expression of Plasmacytoid Dendritic Cell Markers in Cutaneous Lupus Erythematosus Subtypes in Skin of Color.
The American Journal of dermatopathologyThe patterns of recurrence in cutaneous lupus erythematosus: A retrospective analysis of subacute cutaneous lupus erythematosus and discoid lupus erythematosus flares.
Journal of the American Academy of DermatologyOff-label use of biologics and janus kinase (JAK) inhibitors for scarring alopecias: a narrative review.
Archives of dermatological researchOutcomes following single level posterior lumbar fusion in patients with systemic and discoid lupus: A retrospective national database study.
North American Spine Society journalDermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus.
Journal of visualized experiments : JoVEDiscoid Lupus Erythematosus Induced by Teriflunomide in a Patient With Multiple Sclerosis: A Case Report.
International journal of rheumatic diseasesAnifrolumab for refractory discoid lupus: Two case reports of successful outcomes in Saudi Arabia.
MedicineFacial follicular porokeratosis simulating discoid lupus erythematosus in an African American woman.
JAAD case reportsProgressive repigmentation of hypopigmented lesions in discoid lupus erythematosus with anifrolumab: A report of two cases.
LupusAdjunctive anifrolumab for recalcitrant discoid lupus erythematosus in the setting of systemic lupus erythematosus: A case report.
JAAD case reportsScarring Alopecia and Risk of Skin Cancer: A Literature Review.
Skin appendage disordersFrom Prescription to Predicament: A Case of Semaglutide-Induced Discoid Lupus Erythematosus in an Adult Male Patient.
CureusCombination Therapy With Voclosporin and Anifrolumab in Two Patients With Lupus Nephritis and Discoid Lupus Erythematosus.
CureusThe application of direct immunofluorescence in the pathological diagnosis of oral mucosal diseases: Series of 116 cases.
Pathology, research and practiceUse of Deucravacitinib in Cutaneous Lupus Erythematosus: Two Patient Experiences at a Combined Rheumatology-Dermatology Clinic.
International journal of dermatologyFlare of bullous lupus erythematosus in patients treated with anifrolumab for discoid lupus erythematosus: 2 cases.
JAAD case reportsComedonal Plaques With Scarring Alopecia on the Scalp: A Case Report.
CureusEosinophils are rare or absent in discoid lupus erythematosus.
Journal of the American Academy of DermatologySkin and beyond: Demographics, clinical features and systemic involvement of cutaneous lupus erythematosus in Pakistani population.
LupusSpatial Transcriptomics Reveals Differential Inflammatory Pathways in Discoid Lupus Erythematosus and Lichen Planus.
The Journal of investigative dermatologyImaging Findings of Lupus Mastitis: A Systematic Review of Case Studies.
CureusRepresentation of skin of color in patient education materials for discoid lupus erythematosus.
Archives of dermatological researchCan Dermoscopy Be a Useful Follow-Up Tool in Patients with Discoid Lupus Treated with Anifrolumab?
Diagnostics (Basel, Switzerland)Synovitis and its association with elevated circulating interferons and hydroxychloroquine response in discoid lupus erythematosus: a cross-sectional study.
Rheumatology internationalAn uncommon presentation of discoid lupus suggesting systemic evolution.
SAGE open medical case reportsTattoo-induced hypertrophic discoid lupus erythematosus in a patient with vitiligo.
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDGDiscoid lupus erythematosus presenting as an unusual giant plaque on face.
Indian journal of dermatology, venereology and leprologyEvaluating biomarkers in canine cytotoxic interface dermatitis reactions to account for clinical and histopathological similarities and differences.
Frontiers in veterinary scienceClinical and Trichoscopic Patterns of Discoid Lupus Erythematosus of Scalp in Patients with Systemic Lupus Erythematosus: An Observational Study.
Indian journal of dermatologyCase Report: Severe Immune-Related Adverse Event Under Pembrolizumab Therapy for Discoid Lupus Erythematosus-Related Squamous Cell Carcinoma.
International journal of rheumatic diseasesEfficacy, safety and tolerability of drugs for alopecia: a comprehensive review.
Expert opinion on drug metabolism & toxicologyA scientometric study on research trends and characteristics of discoid lupus erythematosus.
Journal of dental sciencesExploring the Therapeutic Landscape: A Narrative Review on Topical and Oral Phosphodiesterase-4 Inhibitors in Dermatology.
PharmaceuticsIn Vivo Characterization of the Inflammatory Infiltrate in Discoid Lupus Erythematosus (DLE) by Line-Field Confocal Optical Coherence Tomography (LC-OCT).
Dermatology practical & conceptualSolitary verrucous plaque on the chin: hypertrophic discoid lupus erythematosus⋆.
Anais brasileiros de dermatologiaEpidemiology of discoid lupus erythematosus among adults in the United States: a cross-sectional analysis.
International journal of dermatologyTreatment of discoid lupus erythematosus scarring alopecia with deucravacitinib: A case report.
SAGE open medical case reportsThe morphological spectrum of cheilitis.
Journal of the American Academy of DermatologyApplication of Ultraviolet-Induced Fluorescence Trichoscopy (UVFT) in Hair and Scalp Diseases.
Dermatology and therapyTreatment of recalcitrant discoid lupus erythematosus with roflumilast 0.3% cream following suboptimal response to anifrolumab and improvement of hypopigmentation.
JAAD case reportsLarge-scale global retrospective study on the interaction between ancestry and risk of comorbid autoimmune diseases in patients with pemphigus.
Scientific reportsSecukinumab-Aggravated Disseminated Discoid Lupus Erythematosus Misdiagnosed as Psoriasis.
CureusRuxolitinib cream for discoid lupus erythematosus: An open-label pilot study of 10 subjects.
Journal of the American Academy of DermatologySpatial Transcriptomics in Inflammatory Skin Diseases Using GeoMx Digital Spatial Profiling: A Practical Guide for Applications in Dermatology.
JID innovations : skin science from molecules to population healthSuccessful treatment of discoid lupus erythematosus with tapinarof 1% cream monotherapy.
JAAD case reportsAcneiform lesions in a 57-year-old woman.
International journal of dermatologyHistopathologic Comparisons of Discoid Lupus Erythematosus and Folliculotropic Mycosis Fungoides in a Series of 43 Cases.
Journal of cutaneous pathologyImatinib associated discoid lupus erythematosus in a patient with chronic myeloid leukemia.
JAAD case reportsOral lichen planus-like lesions in skin of color: a review.
International journal of dermatology[Translated article] Use of Anifrolumab in Systemic Lupus Erythematosus, Cutaneous Lupus Erythematosus, and Other Autoimmune Dermatoses.
Actas dermo-sifiliograficasTrichoscopy of Discoid Lupus Erythematosus in Caucasian Scalp: A Review.
Skin appendage disordersTreatment of discoid lupus with lenalidomide and anifrolumab: Case report and review of the literature.
LupusDiscoid Lupus Erythematosus.
The New England journal of medicineDiagnostic dilemma in pigmented basal cell carcinoma: A case report.
Journal of education and health promotionPerformance of the Systemic Lupus Erythematosus Risk Probability Index (SLERPI) in a cohort of Colombian population.
Clinical rheumatologyCutaneous Squamous Cell Carcinoma Arising Within Discoid Lupus Erythematosus-Utilizing Acitretin and Hydroxychloroquine to Preoperatively Decrease Lupus Burden.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]Comorbidities associated with discoid lupus erythematosus: A case-control study in the All of Us Research Program.
Experimental dermatologyMucosal Cancers Arising in Potentially Malignant Lesions of the Oral Mucosa Are Marjolin Ulcers: New Insights Into Old Concepts.
Dermatology practical & conceptualSurgical Excision Combined with Photodynamic Therapy for Squamous Cell Carcinoma Arising in Lupus Vulgaris.
Clinical, cosmetic and investigational dermatologyResolution of Discoid Lupus Alopecia With Systemic Hydroxychloroquine and Topical Pimecrolimus Combination Therapy.
CureusDistinct Patient Disease Profiles in Discoid Lupus Erythematosus and Subacute Lupus Erythematosus: A Retrospective Study.
Journal of cutaneous medicine and surgeryArea Deprivation and Disease Severity in Adult Patients With Discoid Lupus Erythematosus.
JAMA dermatologyTrichoscopy of Discoid Lupus Erythematosus in the Black Scalp: A Literature Review.
Skin appendage disordersDisseminated Hypertrophic Discoid Lupus Erythematosus in a Patient with Vitiligo: A Case Report and Literature Review.
Clinical, cosmetic and investigational dermatologyLichen Planus of the Lip-Case Series and Review of the Literature.
Medicina (Kaunas, Lithuania)Many faces of cutaneous leishmaniasis.
Postgraduate medical journalImpressive resolution of refractory hypertrophic discoid lupus erythematosus with anifrolumab.
BMJ case reportsDiscoid lupus erythematosus successfully treated with deucravacitinib.
JAAD case reportsEfficacy of topical tacrolimus monotherapy against pediatric discoid lupus erythematosus.
The Journal of dermatologyA benign masquerade of eyelid malignancy: Discoid lupus erythematosus.
Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological SocietyLupus Erythematosus Tumidus as a Distinct Uncommon Subtype of Cutaneous Lupus Erythematosus: A Case Report and Review.
CureusReflectance confocal microscopy in pediatric patients with Sweet's syndrome: a useful method to differentiate from discoid lupus erythematosus.
Archives of dermatological researchDiscoid lupus erythematosus affecting the scalp.
JAAD case reportsHalting the Progression of Cicatricial Alopecia with Injectable Platelet-Rich Fibrin.
International journal of trichologySystemic correlates of cutaneous manifestations of lupus erythematosus.
International journal of dermatologyDermoscopy to differentiate clinically similar inflammatory and neoplastic skin lesions.
Italian journal of dermatology and venereologyThe role of thymic stromal lymphopoietin in cutaneous disorders.
Archives of dermatological researchTrichoscopic Features of Scalp Discoid Lupus Erythematosus versus Lichen Planopilaris: A Systematic Review.
Clinical, cosmetic and investigational dermatologyEfficacy of anifrolumab in long-term intractable alopecia due to discoid lupus erythematosus.
Modern rheumatology case reportsTreatment With Voclosporin and Anifrolumab in a Patient With Lupus Nephritis and Refractory Discoid Lupus Erythematosus: A Case Report and Literature Review.
CureusLinear discoid lupus erythematous simulating en coup de sabre morphea in a female chronic granulomatous disease carrier.
Dermatology online journalScreening of Genes Associated with Immune Infiltration of Discoid Lupus Erythematosus Based on Weighted Gene Co-expression Network Analysis.
Biochemical geneticsOral lesions in adult- and juvenile-onset systemic lupus erythematosus patients: A case series report.
Dental and medical problemsAtorvastatin-induced Lupus Erythematosus Tumidus: A Case Report and Literature Review.
Acta dermatovenerologica Croatica : ADCA gyrate pattern of discoid lupus erythematosus.
The Journal of dermatologyCase report: Cannabinoid therapy for discoid lupus erythematosus in a dog.
Frontiers in veterinary sciencePainful Limb Ulcers: A Case Report on Ulcerative Discoid Lupus Erythematosus.
CureusPapulonodular mucinosis with features of discoid lupus erythematosus.
JAAD case reportsAn impressive case of Rowell syndrome with extensive mucosal involvement successfully treated with anifrolumab.
JAAD case reportsDiscoid Lupus Erythematosus along the Lines of Blaschko in an Adult: A Case Report.
Indian journal of dermatologyTrichoscopic findings of discoid lupus erythematosus.
Journal of the European Academy of Dermatology and Venereology : JEADVSquamous Cell Carcinoma Arising From Discoid Lupus Erythematosus.
Journal of cutaneous medicine and surgeryConcentrated growth factor therapy as cosmetic treatment in discoid lupus erythematosus.
The Journal of dermatologyAtypical Dyschromia in Skin of Color.
Journal of drugs in dermatology : JDDInteresting Mucocutaneous Manifestations in COVID-19 Infection or Vaccination Confirmed by Histopathology: A Case Series.
Case reports in dermatologyThe treatment of primary cicatricial alopecia is challenging.
Journal of the American Academy of DermatologyUncommon manifestation of discoid lupus erythematosus in a human immunodeficiency virus patient.
Indian journal of sexually transmitted diseases and AIDSOptical coherence tomography: Promising imaging technique for the diagnosis of oral mucosal diseases.
Oral diseasesMorphea-like discoid lupus erythematosus in a patient with a history of polyacrylamide gel injection: A case report.
Journal of cosmetic dermatologyPrevalence of Oral Submucous Fibrosis With Other Oral Potentially Malignant Disorders: A Clinical Retrospective Study.
CureusAssociations Between Autoimmune Disease and the Development of Age-Related Macular Degeneration.
Investigative ophthalmology & visual sciencePlasmacytoid Dendritic Cells Are Not Major Producers of Type 1 IFN in Cutaneous Lupus: An In-Depth Immunoprofile of Subacute and Discoid Lupus.
The Journal of investigative dermatologyCase report of canine discoid lupus erythematosus in Guatemala.
Veterinary medicine and scienceCornu Cutaneum: Case Reports of Patients With a Cutaneous Horn Associated With Either a Verruca Vulgaris or an Inverted Follicular Keratosis and a Review of the Etiologies of Cutaneous Horns.
CureusCutaneous Toll-like Receptor 9 Pre-Defines Hydroxychloroquine Dosage in Patients with Both Discoid and Subacute Lupus Erythematosus.
Medicina (Kaunas, Lithuania)Letter re: Lupus erythematosus masquerading as acneiform lesions: two cases and review of the literature.
LupusA Rare Manifestation of Discoid Lupus Erythematosus Solely in the Lower Eyelid of a Young Man.
CureusSubacute cutaneous lupus erythematosus versus discoid lupus erythematosus: A challenging diagnosis.
JAAD case reportsMy-Lupus: A case of anti-transcriptional intermediary factor 1-gamma antibody-positive dermatomyositis overlapping with discoid lupus erythematosus in an adult patient.
JAAD case reportsEfficacy of upadacitinib in a case of resistant lupus erythematosus tumidus.
Journal of the European Academy of Dermatology and Venereology : JEADVAnifrolumab for Adolescent Discoid Lupus Erythematosus.
JAMA network openTreatment of Discoid Lupus Erythematosus with Upadacitinib: A Case Report.
Clinical, cosmetic and investigational dermatologyChange in disease activity needed for meaningful change in cutaneous lupus by patient characteristic: A retrospective analysis of a longitudinal database.
Journal of the American Academy of DermatologyLupus Erythematosus Profundus with Multiple Overlying Cutaneous Ulcerations: A Rare Case.
Clinical, cosmetic and investigational dermatologyRaman spectroscopy and mass spectrometry identifies a unique group of epidermal lipids in active discoid lupus erythematosus.
Scientific reportsA mimicker of inflammatory breast carcinoma: Lupus mastitis and evolving imaging features.
Journal of clinical ultrasound : JCUDiscoid lupus erythematosus of the nail treated with thalidomide.
JAAD case reportsClinical epidemiology of tumid lupus erythematosus: A retrospective review of 179 patients.
Journal of the American Academy of DermatologyThe Role of Lasers in Connective Tissue and Inflammatory Dermatoses: A 10-Year Retrospective Review of 60 Patients in a UK Tertiary Laser Clinic.
Indian dermatology online journalDiscoid lupus erythematosus associated with chronic granulomatous disease.
Dermatology reportsThe Possible Clinical Significance of a Decreased Serum Level of Soluble PD-L1 in Discoid Lupus Erythematosus, but Not in Subacute Cutaneous Lupus Erythematosus-A Pilot Study.
Journal of clinical medicineRisk and prevalence of oral cancer in patients with different types of lupus erythematosus: a systematic review and meta-analysis.
Oral surgery, oral medicine, oral pathology and oral radiologyMisdiagnosed Progressive Multifocal Leukoencephalopathy (PML) in an HIV-Negative Patient With Discoid Lupus: A Case Report.
CureusThe dermatoscope in the hair clinic: Trichoscopy of scarring and nonscarring alopecia.
Journal of the American Academy of DermatologyCross-sectional study to evaluate the utility of elastic tissue staining in primary cicatricial alopecia.
Journal of clinical pathologyEvaluation of the Involvement of Heme Oxygenase-1 Expression in Discoid Lupus Erythematosus Lesions.
Antioxidants (Basel, Switzerland)Alopecia secondary to severe discoid lupus responding to anifrolumab.
International journal of women's dermatologyIncreased risk of depression in patients with discoid lupus erythematosus: a nested, case-control study in the All of Us Research Program.
The British journal of dermatologyDiscoid Lupus Erythematosus of the Palms.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseasesClinical, histological and direct immunofluorescence features in oral mucosal patches striae diseases with malignant potential.
Journal of dental sciencesRole of Anifrolumab in Refractory Cutaneous Manifestations of Lupus Erythematosus: A Case Series and Literature Review.
CureusHistopathologic Spectrum of Alopecias Seen in a Jamaican Setting.
The American Journal of dermatopathologySquamous Cell Carcinoma Arising in Discoid Lupus Erythematosus of the Nail Unit.
Skin appendage disordersIntralesional Certolizumab for Refractory Lupus Pernio.
JAMA dermatologyThe differential panorama of clinical features of lupus erythematosus patients with different onset ages: a cross-sectional multicenter study from China.
Clinical rheumatologyRisk factors of progression from discoid lupus to severe systemic lupus erythematosus: More evidence will be needed: Authors reply.
Journal of the American Academy of DermatologyOcular Discoid Lupus Erythematosus: More Than what Meets The Eye.
Indian dermatology online journalUnusual case of adult-onset cutaneous lupus erythematosus mimicking early mycosis fungoides.
Oxford medical case reportsA Case of Mixed Connective Tissue Disease That Transformed Into Systemic Lupus Erythematosus After a Long Clinical Course.
CureusSarcoidosis Coexisting With Distinct Forms of Alopecia on the Scalp: A Case Series.
The American Journal of dermatopathologyImprovement in mucosal discoid lupus erythematosus with anifrolumab.
Clinical and experimental dermatologyAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
Ainda não temos associações cadastradas para Lúpus eritematoso discoide.
É de uma associação que acompanha esta doença? Fale com a gente →
Doenças relacionadas
Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico
Perguntas frequentes
O que as famílias mais perguntam sobre esta doença — cada resposta com a fonte de onde saiu
Existe um documento oficial para "Lúpus Eritematoso Sistêmico". Ele pode não cobrir esta forma específica da doença — confira no texto do protocolo antes de contar com ele.
É uma doença autoimune crônica da pele que causa erupções avermelhadas e com descamação no rosto, orelhas e couro cabeludo. Essas lesões podem levar ao surgimento de cicatrizes atróficas permanentes e alteração na pigmentação da pele.
Referências
Fontes citadas no texto, publicações do grafo e bases de dados usadas neste verbete
10 publicações do grafo RarasNet (PubMed) · 6 bases de dados. Títulos, periódicos e PMIDs vêm direto da fonte, sem intermediação de IA.
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Citar este verbete
Raras. (s.d.). Lúpus eritematoso discoide. Em Raras — Enciclopédia de Doenças Raras do Brasil. https://raras.org/doenca/lupus-eritematoso-discoide
Formato APA. Conteúdo sob CC BY 4.0 — reuso livre com atribuição.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
Lúpus eritematoso discoide
📋 Origem dos dados
Esta página agrega dados de fontes públicas e oficiais. Dados sobre cobertura no SUS (PCDT, CEAF) são verificados ativamente por agente proativo (ver badge no infobox). Demais dados têm atribuição de fonte + data da última sincronização — clique para abrir o original.
- Doença rara (ontologia)
- fonte: Orphanet
- Identificador unificado
- fonte: MONDO
- Codificação WHO/SUS
- fonte: WHO ICD-10 / DATASUS
- CID-11 (futuro)
- fonte: WHO ICD-11
- NIH/GARD
- fonte: GARD (NIH)
- Indexação biomédica
- fonte: MeSH (NLM)
- Dado público estruturado
- fonte: Wikidata
- Medicamentos aprovados FDA
- fonte: FDA OpenFDA
- Reposicionamento
- fonte: Drug Repurposing Hub
- Ensaios clínicos
- fonte: ClinicalTrials.gov
