IVNS1ABP mutation drives cellular senescence in newly identified progeroid neuropathy.

The tight bond between Fanconi anemia and aging.

Fontaine progeroid syndrome into early adolescence: a case report.

Novel POLR3A Gene Mutation Results in Wiedemann-Rautenstrauch Syndrome With Striking Cutis Laxa and Myelofibrosis.

Growth Hormone Response in a Child With a Homozygous TOMM7 Mutation: Novel Therapeutic Insights.

Progeroid Syndrome with Signs of Autophagy Dysfunction in the Naked Mole Rat (Heterocephalus glaber).

Severe cardiac valvular calcification in two Chinese brothers with mandibuloacral dysplasia type A: a case report.

Fontaine progeroid syndrome with neonatal mitochondrial disease.

POLR3A mutations cause nucleolus abnormalities and aberrant telomerase RNA metabolism in induced pluripotent stem cells from Wiedemann-Rautenstrauch premature aging syndrome patient.

Clinical and molecular insights into Wiedemann-Rautenstrauch syndrome: A case report and genetic analysis of the c.2707G>A variant in the POLR3A gene.

Inherited Lipodystrophy Associated With POLD1 and CAVIN1 Mutations: Two Cases From the Indian Subcontinent.

Progeroid features in a patient with Malouf syndrome due to a rare LMNA variant: a case report and review of the literature.

Insights Into Cockayne Syndrome Type B: What Underlies Its Pathogenesis?

A real-world pharmacovigilance assessment and literature review of lymphoma development in lipodystrophy.

Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double-Blind Randomized Crossover Placebo-Controlled Trial.

Founder Pathogenic Variant in LMNA with Diverse Phenotypic Manifestations in Mandibuloacral Dysplasia: Insights from a Turkish Cohort.

CEBPA-associated familial acute myeloid leukemia mimicking Werner syndrome: a case report.

A Case of Penttinen Syndrome With Radiographic Acroosteolysis From Age 3 Years.

A Case of Mandibuloacral Dysplasia Progeroid Syndrome Presented as In Utero Growth Restriction.

Circular RNA Telomerase Reverses Endothelial Senescence in Progeria.

For early diagnosis of young patients with Werner syndrome: Indication for genetic testing.

Less frequent skin ulcers among patients with Werner syndrome treated with pioglitazone: findings from the Japanese Werner Syndrome Registry.

Supplementation with nicotinamide limits accelerated aging in affected individuals with cockayne syndrome and restores antioxidant defenses.

The Ercc1-/Δ mouse model of XFE progeroid syndrome undergoes accelerated retinal degeneration.

Disorganized chromatin hierarchy and stem cell aging in a male patient of atypical laminopathy-based progeria mandibuloacral dysplasia type A.

Validation of metaxin-2 deficient C. elegans as a model for MandibuloAcral Dysplasia associated to mtx-2 (MADaM) syndrome.

Anesthetic management of a patient with mandibular hypoplasia, deafness, progeroid features, lipodystrophy syndrome: a case report.

Bi-Allelic Splicing Variant, c.153-2A > C in TOMM7 Is Associated With Leigh Syndrome.

Lipodystrophic Laminopathies: From Dunnigan Disease to Progeroid Syndromes.

A novel role for CSA in the regulation of nuclear envelope integrity: uncovering a non-canonical function.

James German and the Quest to Understand Human RECQ Helicase Deficiencies.

Prenatal diagnosis of SLC25A24 Fontaine progeroid syndrome: description of the fetal phenotype, genotype and detection of parental mosaicism.

[Wiedemann-Rautenstrauch syndrome. The first description of a clinical case in the Russian Federation].

LEMD2-associated progeroid syndrome: Expanding the phenotype of the nuclear envelopathy caused by a defect in LEMD2 gene.

Case report: A novel splice-site mutation of MTX2 gene caused mandibuloacral dysplasia progeroid syndrome: the first report from China and literature review.

Atypical Progeria Primarily Manifesting as Premature Cardiac Valvular Disease Segregates with LMNA-Gene Variants.

p53 regulates diverse tissue-specific outcomes to endogenous DNA damage in mice.

Immunity in the Progeroid Model of Cockayne Syndrome: Biomarkers of Pathological Aging.

The Genetic Basis of the First Patient with Wiedemann-Rautenstrauch Syndrome in the Russian Federation.

Further delineation of Wiedemann-Rautenstrauch syndrome linked with POLR3A.

A Novel Variant in the WRN Gene Detected in a Case of Early-Onset Severe Insulin Resistance Displaying Some but Not All Hallmarks of Progeroid Werner Syndrome.

Nuclear Abnormalities in LMNA p.(Glu2Lys) Variant Segregating with LMNA-Associated Cardiocutaneous Progeria Syndrome.

The farnesyl transferase inhibitor (FTI) lonafarnib improves nuclear morphology in ZMPSTE24-deficient fibroblasts from patients with the progeroid disorder MAD-B.

Flame-like Calcifications in Werner Syndrome.

The third case of Marbach-Rustad progeroid syndrome caused by a de novo LEMD2 variant.

Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation.

Senescence, regulators of alternative splicing and effects of trametinib treatment in progeroid syndromes.

Caspase 5 depletion is linked to hyper-inflammatory response and progeroid syndrome.

Insights into aging from progeroid syndrome epigenetics.

Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels.

A subtype of laminopathies: Generalized lipodystrophy-associated progeroid syndrome caused by LMNA gene c.29C>T mutation.

Performance evaluation of CMIP6 climate models for selecting a suitable GCM for future precipitation at different places of Tamil Nadu.

Multi-omic analysis of mandibuloacral dysplasia type A patient iPSC-derived MSC senescence reveals miR-311 as a novel biomarker for MSC senescence.

A recurrent homozygous LMNA missense variant p.Thr528Met causes atypical progeroid syndrome characterized by mandibuloacral dysostosis, severe muscular dystrophy, and skeletal deformities.

Different GCMs yet similar outcome: predicting the habitat distribution of Shorea robusta C.F. Gaertn. in the Indian Himalayas using CMIP5 and CMIP6 climate models.

Spectrum of Pediatric to Early Adulthood POLR3A-Associated Movement Disorders.

Case report: Variants in the ERCC4 gene as a rare cause of cerebellar ataxia with chorea.

From cue to meaning: The involvement of POLD1 gene in DNA replication, repair and aging.

A progeroid syndrome caused by a deep intronic variant in TAPT1 is revealed by RNA/SI-NET sequencing.

Progeroid syndrome of De Barsy - a case report and review of ophthalmic literature.

Optical coherence tomography findings in three patients with Werner syndrome.

Adult progeria: a new mutation in the WRN gene.

Case report: Focal segmental glomerulosclerosis in a pediatric atypical progeroid syndrome.

Neuropathology of classic myotonic dystrophy type 1 is characterized by both early initiation of primary age-related tauopathy of the hippocampus and unique 3-repeat tauopathy of the brainstem.

Autosomal recessive progeroid syndrome due to homozygosity for a TOMM7 variant.

A novel MTX2 gene splice site variant resulting in exon skipping, causing the recently described mandibuloacral dysplasia progeroid syndrome.

A Case of Wiedemann-Rautenstrauch Syndrome With Fatal Hyperkalemic Renal Faliure.

Fontaine progeroid syndrome-A case report.

Asprosin, a C-Terminal Cleavage Product of Fibrillin 1 Encoded by the FBN1 Gene, in Health and Disease.

Targeted long-read sequencing identifies missing pathogenic variants in unsolved Werner syndrome cases.

Severe aortic stenosis during leptin replacement therapy in a patient with generalized lipodystrophy-associated progeroid syndrome due to an LMNA variant: A case report.

Successful surgical aortic valve replacement in a patient with progeria.

Post-acute cardiac complications following SARS-CoV-2 infection in partial lipodystrophy due to LMNA gene p.R349W mutation.

A high prevalence of myeloid malignancies in progeria with Werner syndrome is associated with p53 insufficiency.

Werner syndrome in a Lebanese family.

Biallelic CAV1 null variants induce congenital generalized lipodystrophy with achalasia.

A novel homozygous synonymous variant further expands the phenotypic spectrum of POLR3A-related pathologies.

Werner syndrome presenting as early-onset diabetes: A case report.

[Progeroid syndrome: A rare model of accelerated aging in human].

The human ribosomal DNA array is composed of highly homogenized tandem clusters.

Whole-exome sequencing reveals POLR3B variants associated with progeria-related Wiedemann-Rautenstrauch syndrome.

Atypical progeroid syndrome (p.E262K LMNA mutation): a rare cause of short stature and osteoporosis.

Wiedemann-Rautenstrauch syndrome in an Indian patient with biallelic pathogenic variants in POLR3A.

Increased insulin sensitivity and diminished pancreatic beta-cell function in DNA repair deficient Ercc1d/- mice.

Cutaneous and metabolic defects associated with nuclear abnormalities in a transgenic mouse model expressing R527H lamin A mutation causing mandibuloacral dysplasia type A (MADA) syndrome.

SMAD4 mutations and cross-talk between TGF-β/IFNγ signaling accelerate rates of DNA damage and cellular senescence, resulting in a segmental progeroid syndrome-the Myhre syndrome.

Evolving clinical manifestations of mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome: From infancy to adulthood in a 31-year-old woman.

The Ercc1-/Δ mouse model of accelerated senescence and aging for identification and testing of novel senotherapeutic interventions.

Neurodevelopmental regression, severe generalized dystonia, and metabolic acidosis caused by POLR3A mutations.

Severe metabolic disorders coexisting with Werner syndrome: a case report.

Nucleolar disruption, activation of P53 and premature senescence in POLR3A-mutated Wiedemann-Rautenstrauch syndrome fibroblasts.

Novel LMNA mutations in Greek and Myanmar Patients with Progeroid Features and Cardiac Manifestations.

Multisystem Progeroid Syndrome With Lipodystrophy, Cardiomyopathy, and Nephropathy Due to an LMNA p.R349W Variant.

Atypical Progeroid Syndrome and Partial Lipodystrophy Due to LMNA Gene p.R349W Mutation.

A Novel Syndrome With Short Stature, Mandibular Hypoplasia, and Osteoporosis May Be Associated With a PRRT3 Variant.

Pathophysiology of premature aging characteristics in Mendelian progeroid disorders.

Mitochondrial Dysfunction, Oxidative Stress, and Neuroinflammation: Intertwined Roads to Neurodegeneration.

Unique combination and in silico modeling of biallelic POLR3A variants as a cause of Wiedemann-Rautenstrauch syndrome.

Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome.

Is Gorlin-Chaudhry-Moss syndrome associated with aortopathy?

Diseases Caused by Mutations in Mitochondrial Carrier Genes SLC25: A Review.

Fibrillin-1 and fibrillin-1-derived asprosin in adipose tissue function and metabolic disorders.

Looking at New Unexpected Disease Targets in LMNA-Linked Lipodystrophies in the Light of Complex Cardiovascular Phenotypes: Implications for Clinical Practice.

Energy Regulation Mechanism and Therapeutic Potential of Asprosin.

Fibrodysplasia Ossificans Progressiva (FOP): A Segmental Progeroid Syndrome.

Recurrent Femoral Fractures in a Boy with an Atypical Progeroid Syndrome: A Case Report.

A 9-year-old Korean girl with Fontaine progeroid syndrome: a case report with further phenotypical delineation and description of clinical course during long-term follow-up.

Inactivating Mutations in Exonuclease and Polymerase Domains in DNA Polymerase Delta Alter Sensitivities to Inhibitors of dNTP Synthesis.

A case of generalized lipodystrophy-associated progeroid syndrome treated by leptin replacement with short and long-term monitoring of the metabolic and endocrine profiles.

A variant of neonatal progeroid syndrome, or Wiedemann-Rautenstrauch syndrome, is associated with a nonsense variant in POLR3GL.

ATP-based therapy prevents vascular calcification and extends longevity in a mouse model of Hutchinson-Gilford progeria syndrome.

Diffuse, mottled hyperpigmentation and mutations in LMNA gene in a 5-year-old boy, his mother, and his grandmother: Atypical progeroid syndrome.

Growing Old Too Fast: A Rare Case of Werner Syndrome.

Diabetes mellitus coexisted with progeria: a case report of atypical Werner syndrome with novel LMNA mutations and literature review.

Epigenetic signatures of Werner syndrome occur early in life and are distinct from normal epigenetic aging processes.

Special-needs patients in pediatric dentistry: Progeroid syndrome. A case of dental management and oral rehabilitation.

The Shape of Mitochondrial Dysfunction in Down Syndrome.

Accelerated bio-cognitive aging in Down syndrome: State of the art and possible deceleration strategies.

POLR3A Identified as Major Locus for Autosomal Recessive Wiedemann-Rautenstrauch Syndrome: New findings show "compelling evidence" that POLR3A mutations underlie the etiology of autosomal-recessive WRS.

A Transcriptome Study of Progeroid Neurocutaneous Syndrome Reveals POSTN As a New Element in Proline Metabolic Disorder.

Analyses of LMNA-negative juvenile progeroid cases confirms biallelic POLR3A mutations in Wiedemann-Rautenstrauch-like syndrome and expands the phenotypic spectrum of PYCR1 mutations.

Bi-allelic POLR3A Loss-of-Function Variants Cause Autosomal-Recessive Wiedemann-Rautenstrauch Syndrome.

CTC1 mutations in a Brazilian family with progeroid features and recurrent bone fractures.

A rare male patient with Fontaine progeroid syndrome caused by p.R217H de novo mutation in SLC25A24.

Specific combinations of biallelic POLR3A variants cause Wiedemann-Rautenstrauch syndrome.

Modeling Alzheimer's disease in progeria mice. An age-related concept.

Fisetin is a senotherapeutic that extends health and lifespan.

Biallelic WRN Mutations in Newly Identified Japanese Werner Syndrome Patients.

A De Novo POLD1 Mutation Associated With Mandibular Hypoplasia, Deafness, Progeroid Features, and Lipodystrophy Syndrome in a Family With Werner Syndrome.

Involvement of the nuclear structural proteins in aging-related responses of human skin to the environmental stress.

Werner syndrome: a rare mutation.

Outpatient Interventions That May Enhance the Care of a Patient with Co-existing Moyamoya and Down Syndromes.

RECQ helicase disease and related progeroid syndromes: RECQ2018 meeting.

The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates.

Potential association of LMNA-associated generalized lipodystrophy with juvenile dermatomyositis.

A Novel Generalized Lipodystrophy-Associated Progeroid Syndrome Due to Recurrent Heterozygous LMNA p.T10I Mutation.

Definitive diagnosis of mandibular hypoplasia, deafness, progeroid features and lipodystrophy (MDPL) syndrome caused by a recurrent de novo mutation in the POLD1 gene.

ERCC4 variants identified in a cohort of patients with segmental progeroid syndromes.

De Novo Mutations in SLC25A24 Cause a Craniosynostosis Syndrome with Hypertrichosis, Progeroid Appearance, and Mitochondrial Dysfunction.

Molecular spectrum of excision repair cross-complementation group 8 gene defects in Chinese patients with Cockayne syndrome type A.

Identification of HSP90 inhibitors as a novel class of senolytics.

Dysfunction of the MDM2/p53 axis is linked to premature aging.

Uncommon cause of cirrhosis-A case of Werner syndrome with a novel WRN mutation.

Werner syndrome: a model for sarcopenia due to accelerated aging.

Wiedemann-Rautenstrauch Syndrome With Bilateral Tarsal Kink: Three Sutures for Correction.

A novel splice-site mutation of WRN (c.IVS28+2T>C) identified in a consanguineous family with Werner Syndrome.

Recent Trends in WRN Gene Mutation Patterns in Individuals with Werner Syndrome.

Homozygosity for the WRN Helicase-Inactivating Variant, R834C, does not confer a Werner syndrome clinical phenotype.

Expansion of myeloid-derived suppressor cells with aging in the bone marrow of mice through a NF-κB-dependent mechanism.

Accurate Detection of Dysmorphic Nuclei Using Dynamic Programming and Supervised Classification.

Progeroid syndrome patients with ZMPSTE24 deficiency could benefit when treated with rapamycin and dimethylsulfoxide.

SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks.

WRN Mutation Update: Mutation Spectrum, Patient Registries, and Translational Prospects.

Neonatal progeriod syndrome associated with biallelic truncating variants in POLR3A.

Increased susceptibility to oxidative stress- and ultraviolet A-induced apoptosis in fibroblasts in atypical progeroid syndrome/atypical Werner syndrome with LMNA mutation.

Defective DNA repair increases susceptibility to senescence through extension of Chk1-mediated G2 checkpoint activation.

Absence of premature senescence in Werner's syndrome keratinocytes.

Lamin Mutations Accelerate Aging via Defective Export of Mitochondrial mRNAs through Nuclear Envelope Budding.

Retinal features in Mulvihill-Smith syndrome.

A Case of Novel Lamin A/C Mutation Manifesting as Atypical Progeroid Syndrome and Cardiomyopathy.

Asprosin, a Fasting-Induced Glucogenic Protein Hormone.

Werner syndrome: Clinical features, pathogenesis and potential therapeutic interventions.

The Werner syndrome RECQ helicase targets G4 DNA in human cells to modulate transcription.

Potential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disorders.

Ophthalmic manifestations in a case of Wiedemann-Rautenstrauch syndrome.

The effect of RO3201195 and a pyrazolyl ketone P38 MAPK inhibitor library on the proliferation of Werner syndrome cells.

Anesthesia in an Aging Infant: Neonatal Progeroid Syndrome.

Mandibular hypoplasia, deafness, progeroid features and lipodystrophy (MDPL) syndrome in the context of inherited lipodystrophies.

Recurrent De Novo Mutations Affecting Residue Arg138 of Pyrroline-5-Carboxylate Synthase Cause a Progeroid Form of Autosomal-Dominant Cutis Laxa.

A New Homozygous IGF1R Variant Defines a Clinically Recognizable Incomplete Dominant form of SHORT Syndrome.

Muscle wasting in myotonic dystrophies: a model of premature aging.

A Frame-Shift Mutation in CAV1 Is Associated with a Severe Neonatal Progeroid and Lipodystrophy Syndrome.

POLD1 Germline Mutations in Patients Initially Diagnosed with Werner Syndrome.

Genomic diagnosis by whole genome sequencing in a Korean family with atypical progeroid syndrome.

Barrier to Autointegration Factor (BANF1): interwoven roles in nuclear structure, genome integrity, innate immunity, stress responses and progeria.

Whole exome sequencing identifies de novo heterozygous CAV1 mutations associated with a novel neonatal onset lipodystrophy syndrome.

"...Rewritten in the skin": clues to skin biology and aging from inherited disease.