Um tumor que se desenvolve nas células de suporte (chamadas gliais) do cérebro ou da medula espinhal, e que apresenta características de astrócitos (um tipo de célula glial). Inclui os seguintes tipos: astrocitoma pilocítico, astrocitoma difuso, astrocitoma anaplásico, xantoastrocitoma pleomórfico, astrocitoma subependimário de células gigantes e glioblastoma.
Introdução
O que você precisa saber de cara
Um tumor que se desenvolve nas células de suporte (chamadas gliais) do cérebro ou da medula espinhal, e que apresenta características de astrócitos (um tipo de célula glial). Inclui os seguintes tipos: astrocitoma pilocítico, astrocitoma difuso, astrocitoma anaplásico, xantoastrocitoma pleomórfico, astrocitoma subependimário de células gigantes e glioblastoma.
Tem tratamento?
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 19 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 33 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
20 genes identificados com associação a esta condição.
GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubM
Cell membraneEndoplasmic reticulum membraneGolgi apparatus membraneNucleus membraneEndosomeEndosome membraneNucleusSecreted
Lung cancer
A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis.
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS) (PubMed:30442762, PubMed:30442766, PubMed:30481304). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes (PubMed:30442762, PubMed:30442766, PubMed:30481304)
Endomembrane systemRecycling endosomeGolgi apparatus
Glioma
Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes.
Receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. NELL2 is an endogenous ligand for ROS1. Upon endogenous stimulation by NELL2, ROS1 activates the intracellular signaling pathway and triggers epididymal epithelial differentiation and subsequent sperm maturation (By similarity). May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including
Cell membrane
Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179)
NucleusCytoplasmCell membrane
Ligand-activated transcription factor that forms obligate heterodimers with the retinoic acid receptor and acts as a key regulator of biological processes, such as adipocyte differentiation, lipid metabolism, glucose homeostasis and beta-oxidation of fatty acids (PubMed:16150867, PubMed:20829347, PubMed:23525231, PubMed:8702406, PubMed:8706692, PubMed:9065481). Activated by lipid ligands: binds peroxisome proliferators, such as hypolipidemic drugs, and fatty acids, such as prostaglandin J2 metab
NucleusCytoplasm
May play a role in photoreceptor function
MembraneCell projection, cilium
Retinitis pigmentosa 86
A form of retinitis pigmentosa, a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP86 is an autosomal recessive form.
Plays a role in intermediary metabolism and energy production (PubMed:19228619, PubMed:22416140). It may tightly associate or interact with the pyruvate dehydrogenase complex (PubMed:19228619, PubMed:22416140)
Mitochondrion
D-2-hydroxyglutaric aciduria 2
A neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features. Both a mild and a severe phenotype exist. The severe phenotype is homogeneous and is characterized by early infantile-onset epileptic encephalopathy and cardiomyopathy. The mild phenotype has a more variable clinical presentation. Diagnosis is based on the presence of an excess of D-2-hydroxyglutaric acid in the urine.
Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity). Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 (PubMed:15494731, PubM
Cell membraneEndosome membraneEarly endosome membraneCell projection, axonCell projection, dendriteCytoplasm, perinuclear regionPostsynaptic density
Developmental and epileptic encephalopathy 58
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE58 is an autosomal dominant condition characterized by onset of refractory seizures in the first days or months of life.
Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase (PubMed:10521434, PubMed:19935646). Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways (PubMed:10521434). May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency (By similarity)
Cytoplasm, cytosolPeroxisome
Glioma
Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes.
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated
Nucleus
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:20949621, PubMed:39809765). Plays an important role in the regulation of cell proliferation (PubMed:22711838, PubMed:23698361). Activates MAPK1/MAPK3 resulting in phosphorylation and ultimately degradation of GJA1 (By similarity). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (PubMed:24623306)
Cell membraneEndomembrane systemCytoplasm, cytosol
Leukemia, acute myelogenous
A subtype of acute leukemia, a cancer of the white blood cells. AML is a malignant disease of bone marrow characterized by maturational arrest of hematopoietic precursors at an early stage of development. Clonal expansion of myeloid blasts occurs in bone marrow, blood, and other tissue. Myelogenous leukemias develop from changes in cells that normally produce neutrophils, basophils, eosinophils and monocytes.
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals (PubMed:1493333, PubMed:36651806, PubMed:7479976). On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription (PubMed:7479976, PubMed:7628694, PubMed:7796813, PubMed:7878466)
CytoplasmNucleus
Ectodermal dysplasia and immunodeficiency 2
A form of ectoderma dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. This form of ectodermal dysplasia is associated with decreased production of pro-inflammatory cytokines and certain interferons, rendering patients susceptible to infection. EDAID2 inheritance is autosomal dominant.
Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:35618207, PubMed:36634798, PubMed:38653238, PubMed:9840937). Acts as a tumor suppressor in many tumor types; induces growth arrest or apop
CytoplasmNucleusNucleus, PML bodyEndoplasmic reticulumMitochondrion matrixCytoplasm, cytoskeleton, microtubule organizing center, centrosome
Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and
CytoplasmCell membraneMitochondrionNucleus
Noonan syndrome 5
A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells.
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (P
CytoplasmCytoplasm, cytoskeleton, microtubule organizing center, centrosomeCytoplasm, cytoskeleton, spindleCytoplasm, cytoskeleton, spindle pole
Filament-forming cytoskeletal GTPase (Probable). Involved in the migration of cortical neurons and the formation of neuron leading processes during embryonic development (By similarity). Plays a role in sperm head formation during spermiogenesis, potentially via facilitating localization of ACTN4 to cell filaments (PubMed:33228246)
CytoplasmCytoplasm, cytoskeletonCell projection, axonCell projection, dendritePerikaryonCytoplasm, perinuclear regionCytoplasmic vesicle, secretory vesicle, acrosome
Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferat
Cell membraneCytoplasmic vesicleEndoplasmic reticulumSecreted
Achondroplasia
A frequent form of short-limb dwarfism. It is characterized by a long, narrow trunk, short extremities, particularly in the proximal (rhizomelic) segments, a large head with frontal bossing, hypoplasia of the midface and a trident configuration of the hands. ACH is an autosomal dominant disease.
Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activati
Cell membraneNucleusCytoplasm, cytosolCytoplasmic vesicle
Pfeiffer syndrome
A syndrome characterized by the association of craniosynostosis, broad and deviated thumbs and big toes, and partial syndactyly of the fingers and toes. Three subtypes are known: mild autosomal dominant form (type 1); cloverleaf skull, elbow ankylosis, early death, sporadic (type 2); craniosynostosis, early demise, sporadic (type 3).
Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues
CytoplasmNucleusCytoplasm, cytoskeleton, microtubule organizing center, centrosomeMidbodyMembrane
Medicamentos e terapias
Mecanismo: Glutathione reductase inhibitor
Mecanismo: FK506-binding protein 1A inhibitor
Mecanismo: Vascular endothelial growth factor A inhibitor
Mecanismo: Dual specificity mitogen-activated protein kinase kinase; MEK1/2 inhibitor
Mecanismo: Tyrosine-protein kinase ABL inhibitor
Mecanismo: Tubulin inhibitor
Mecanismo: Tubulin inhibitor
Mecanismo: Tyrosine-protein kinase ABL inhibitor
Mecanismo: Dual specificity mitogen-activated protein kinase kinase; MEK1/2 inhibitor
Mecanismo: Ribonucleoside-diphosphate reductase RR1 inhibitor
Variantes genéticas (ClinVar)
1,975 variantes patogênicas registradas no ClinVar.
Classificação de variantes (ClinVar)
Distribuição de 13 variantes classificadas pelo ClinVar.
Vias biológicas (Reactome)
177 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Astrocitoma
Selecione um estado ou use sua localização para ver resultados.
Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
🟢 Recrutando agora
4 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.
Outros ensaios clínicos
2.243 ensaios clínicos encontrados, 13 ativos.
Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 5.302
TERT Promoter Methylation in Glioblastoma and its Paradoxical Association with Upregulated Gene Expression.
Este estudo demonstra que, em glioblastomas (uma forma agressiva de astrocitoma), o gene TERT, fundamental para a proliferação do tumor, exibe uma hipermetilação em seu promotor. De forma paradoxal, essa alteração epigenética não silencia o gene, mas sim aumenta sua expressão, impulsionando a patologia da doença. Os achados sugerem que agentes desmetilantes podem ser uma importante estratégia terapêutica para inibir a atividade do TERT e, consequentemente, o crescimento das células cancerígenas.
🇧🇷 traduzidoHigh-Grade Astrocytoma With Piloid Features: An Aggressive Clinicogenomic Entity Distinct From Pilocytic Astrocytoma.
Este estudo identifica o Astrocitoma de Alto Grau com Características Pilóides (HGAP) como uma nova entidade clinicogenômica agressiva, claramente distinta do Astrocitoma Pilocítico (AP) pediátrico e adulto. Para pacientes e médicos, é crucial saber que o HGAP afeta predominantemente adultos, possui perfis genéticos únicos (como deleções CDKN2A/B e mutações NF1/ATRX) e está associado a uma sobrevida significativamente mais curta em comparação com o AP, que geralmente tem um prognóstico mais favorável. Esta distinção ressalta a importância da análise molecular precisa para um diagnóstico correto, orientação prognóstica e para o desenvolvimento de estratégias terapêuticas mais eficazes.
🇧🇷 traduzidoAssociation of CDKN2A/B and MTAP deletions in adult-type diffuse gliomas.
Em gliomas difusos do tipo adulto, a perda de genes CDKN2A/B e MTAP frequentemente ocorre em conjunto, levantando a possibilidade de que o teste de MTAP por imuno-histoquímica (IHC) pudesse indicar o status de CDKN2A/B. No entanto, este estudo revela que, embora a perda de um exemplar de ambos os genes seja comum, a perda completa de CDKN2A/B nem sempre significa a perda completa de MTAP devido a diferentes mecanismos genéticos. Isso significa que o teste de MTAP por IHC não é um substituto totalmente confiável para determinar o status de CDKN2A/B em todos os casos, e a avaliação genômica direta pode ser necessária para uma compreensão precisa e decisões clínicas.
🇧🇷 traduzidoCentral Precocious Puberty and Optic Pathway Glioma in Children with Neurofibromatosis 1: Associations with Tumor Location, Vision, and Treatment.
Em crianças com Neurofibromatose 1 (NF1) e gliomas das vias ópticas (GVOs), pode ocorrer puberdade precoce central (PPC). Este estudo demonstrou que a PPC nesses pacientes está associada a tumores localizados no hipotálamo, uma visão mais comprometida e uma maior probabilidade de o GVO precisar de tratamento. Para pacientes e médicos, isso significa que a PPC é um importante sinal que indica a necessidade de uma avaliação cuidadosa da localização do tumor, do estado da visão e da possível urgência de intervenção terapêutica.
🇧🇷 traduzidoLaser interstitial thermal therapy and adjuvant pembrolizumab in recurrent high-grade astrocytoma: a Phase 1/randomized Phase 2b trial.
Este estudo avaliou uma nova estratégia para o astrocitoma de alto grau recorrente, uma doença de difícil tratamento, combinando a terapia térmica intersticial a laser (LITT) com o imunoterápico pembrolizumab, já que imunoterapias sozinhas mostram pouca eficácia. Os resultados foram muito positivos, com a combinação LITT + pembrolizumab melhorando significativamente a sobrevida global (mediana de 11.8 vs 5.2 meses) e a sobrevida livre de progressão em comparação com a cirurgia sem LITT, levando inclusive à interrupção precoce do estudo por benefício. A terapia foi bem tolerada e sugere que a LITT pode "preparar" o tumor, ativando o sistema imune para que o pembrolizumab seja mais eficaz, oferecendo uma nova e promissora opção para pacientes e médicos.
🇧🇷 traduzidoPublicações recentes
Sudden death from a clinically silent right insular infarct in a patient with prior left insular astrocytoma.
[Features of brain involvement in tuberous sclerosis patients in the Republic of Bashkortostan].
CNS tumor type prevalence according to age group: an analysis of 21,000 cases confirmed by methylation profiling, with a focus on adolescents and young adults.
Gasdermin as a Molecular Signature and Predictor of Adult-Type Diffuse Glioma Severity and Grading.
Microsurgical Resection of Subependymal Giant Cell Astrocytoma: Single-Center Retrospective Analysis and Meta-Analysis.
📚 EuropePMC4.802 artigos no totalmostrando 199
A 57-year-old male with diffuse astrocytoma in the lateral ventricle: case report.
BMC neurologyNested pediatric low-grade glioma cerebral organoid avatars reveal glutamatergic neuron stromal growth dependency.
Genes & developmentThe Causal Role of Circulating Inflammatory Cytokines in Brain Tumors: Insights from Genetic Epidemiology.
Immunological investigationsLessons from Exceptional Responders with High-Grade Brain Tumors Treated with Precision Targeted Therapies.
Journal of immunotherapy and precision oncologyIs maternal smoking during pregnancy associated with childhood brain tumors? A systematic literature review.
Toxicology lettersStereotactic radiosurgery for pilocytic astrocytoma: A single center retrospective study.
Neurosurgical reviewPilocytic astrocytoma surgery via the pineal region in a 9-year-old boy via the infratentorial-supracerebellar approach.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryCase Report: Molecular diagnostics and clinical courses of two adult spinal pilocytic astrocytoma long-term survivors with GTF2I::BRAF fusion.
Frontiers in oncologyT2-FLAIR mismatch sign in nonenhancing astrocytoma, IDH-mutant: impact of tumor area on diagnostic sensitivity.
Journal of neuro-oncologyIdentification of BRAF V600E Mutation in Cerebrospinal Fluid Aids in Diagnosing Leptomeningeal Carcinomatosis Arising From Pleomorphic Xanthoastrocytoma: A Case Report.
Cancer reports (Hoboken, N.J.)Impact of corticosteroid administration on glioblastoma progression before and after adjuvant treatments: recent updates on contradictory findings and mechanistic interactions.
Frontiers in oncologyPD-L1 Expression in Gliomas: A Potential Immunotherapeutic Target in High-grade Tumours.
Prague medical reportPrognostic significance of CDKN2A/B hemizygous deletion in IDH-mutant astrocytomas: a systematic review and meta-analysis.
Brain tumor pathologyThoracic intramedullary spinal cord astrocytoma associated with syringomyelia: a case report of gross total resection.
International journal of surgery case reportsFGFR1:TACC1-Fused Pilocytic Astrocytoma in a Child With Muenke Syndrome: A Case Report.
Pediatric blood & cancerAlexander disease mutations differentially sensitize glial fibrillary acidic protein (GFAP) to posttranslational modifications and network disruption by oxidants.
Redox biologyBRAFV600E-mutated central nervous system tumors benefit from treatment with dabrafenib plus trametinib: Results from the Drug Rediscovery Protocol.
European journal of cancer (Oxford, England : 1990)Exploiting Metabolic Dependencies for Therapeutic Targeting of Brain Cancers.
Cancer lettersVebreltinib for Previously Treated Astrocytoma, IDH-Mutant, Grade 4, and Glioblastoma, IDH Wild-Type with PTPRZ1-MET Fusion Gene: A Multicenter, Phase III Randomized, Open-Label Trial.
Cancer communications (London, England)TERT Promoter Methylation in Glioblastoma and its Paradoxical Association with Upregulated Gene Expression.
Neurology IndiaPrognostic relevance of resection at first recurrence in isocitrate dehydrogenase mutant lower-grade glioma: results from a retrospective, single-center, volumetric analysis.
Journal of neuro-oncologyIdentifying clinically relevant cell state interactions in the tumor microenvironment of IDH-mutant gliomas using CSI-TME.
Molecular systems biologyHigh-Grade Astrocytoma With Piloid Features: An Aggressive Clinicogenomic Entity Distinct From Pilocytic Astrocytoma.
Journal of Korean medical scienceAssociation of CDKN2A/B and MTAP deletions in adult-type diffuse gliomas.
Journal of neuropathology and experimental neurologyHigh-grade gliomas and Lynch syndrome: A retrospective descriptive study with a literature review.
Neuro-oncology practiceTele-cognitive rehabilitation for adult lower-grade glioma: An interim prospective pilot feasibility study.
Neuro-oncology practiceDifferentiating medulloblastoma and pilocytic astrocytoma in children based on multimodal MRI radiomics model.
NeuroradiologyPTPN11-related Noonan syndrome predisposes to multifocal low-grade CNS tumors harboring FGFR1 variants.
Journal of neuro-oncologyClinicopathologic, molecular and tumor immune microenvironment features of mismatch repair-deficient glioblastomas in Lynch syndrome: a multicenter study of 29 cases with therapeutic implications.
Acta neuropathologica communicationsCentral Precocious Puberty and Optic Pathway Glioma in Children with Neurofibromatosis 1: Associations with Tumor Location, Vision, and Treatment.
The Journal of pediatricsPrimary Pediatric Brain Tumors in a Tertiary Referral Center in Iran: A 13-Year Retrospective Analysis.
Archives of Iranian medicineSeizure Presentation of a Grade II Astrocytoma in a Patient With Ollier's Disease: A Case Report and Brief Review.
CureusA multifocal IDH-mutant glioma with differential response to IDH inhibition: Role of quantitative neuroimaging.
Radiology case reportsNuclear and membrane-bound hormone receptors in glioblastoma: Expression, functionality, and therapeutic implications.
Neuro-oncology advancesMultifocal cerebral and orbital neoplastic lesions in a 2-year-old child: a case report and literature review emphasizing diagnostic uncertainty and ethical decision-making.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryDNA copy number patterns reveal prognostic markers and elucidate mechanisms of evolution in IDH-mutant astrocytoma.
Neuro-oncologyProteomics in IDH-mutated diffuse lower-grade glioma: a scoping review.
Neuro-oncology advancesA Systematic Review and Meta-Analysis of Executive Function Outcomes in Pediatric Central Nervous System Tumor Survivors.
Actas espanolas de psiquiatriaLaser interstitial thermal therapy and adjuvant pembrolizumab in recurrent high-grade astrocytoma: a Phase 1/randomized Phase 2b trial.
Nature communicationsAn Evaluation Study of PET Image Quality Factors in Brain Tumor Diagnosis.
Tomography (Ann Arbor, Mich.)Pediatric Pilocytic Astrocytoma, Rich in Oligodendrocyte-Like Cells: A Diagnostic Challenge.
Journal of pediatric hematology/oncologyA Case of IDH-Mutant Astrocytoma Harboring an IDH2 R172_H173delinsSN Variant.
Neuropathology : official journal of the Japanese Society of NeuropathologyFluid Suppression Techniques Combined With Amide Proton Transfer-Weighted Imaging for the Evaluation of Adult-Type Diffuse Gliomas.
Korean journal of radiologyManagement of glioblastoma intramedullary spinal cord metastasis with advanced intraoperative techniques: a case series and systematic review.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of AustralasiaThe expression pattern and prognostic relevance of p120-catenin, COL4A2 and SOX10 in glioma.
Frontiers in oncologySingle-cell RNA sequencing suggests different progenitor lineages between IDH mutant and IDHwt glioma.
Neuro-oncology advancesPlacental small extracellular vesicles as modulators of bisphenol A-induced oxidative stress and mitochondrial activation in human astrocytoma cells (U-373 MG).
American journal of physiology. Cell physiologyCross face nerve grafting for reinnervation of nasal and tongue mucosa following trigeminal nerve injury.
JPRAS openSurgical Management of Optic Pathway-Hypothalamic Gliomas: Institutional Experience and Systematic Review.
Operative neurosurgery (Hagerstown, Md.)CATNON conclusion: Closure on Concurrent Chemotherapy in IDHmt Grade 3 Astrocytoma.
Neuro-oncologyRCBVmax from DSC Perfusion MRI as a Supportive Imaging Biomarker for Differentiating IDH-Mutant Astrocytomas and Oligodendroglioma.
Clinical neuroradiologyTransfer Learning Strategies for Pathological Foundation Models: A Systematic Evaluation in Brain Tumor Classification.
Pathology internationalIvosidenib treatment in IDH-mutant WHO grade 4 astrocytomas: illustrative case.
Journal of neurosurgery. Case lessonsClinical profiles of tuberous sclerosis complex: A regionally based survey.
Brain & developmentPilocytic astrocytoma in pediatric and adult patients: a single-center analysis of 650 cases.
Virchows Archiv : an international journal of pathologySpontaneous contrast enhancement fluctuation in adult pilocytic astrocytoma.
RadiologiaMolecular and clinical prognostic factors in isocitrate dehydrogenase-mutant astrocytomas: Insights into biomarker-driven stratification.
Journal of neuropathology and experimental neurology18F-DOPA PET Silence in High-grade Glioma Subtype F: A Distinct Metabolic Phenotype.
Clinical nuclear medicineRedundancy in Growth Factor Receptor Signaling in Adult Astrocytoma Resistance to Small-Molecule Tyrosine Kinase Inhibitors.
International journal of molecular sciencesLong-term administration of the mutant IDH inhibitor DS-1001b suppresses the growth of IDH1-mutant glioma in vitro and in mouse xenograft models and alters epigenetic profiles.
Acta neuropathologicaImpact of prenatal sirolimus on cardiac rhabdomyomas and brain tubers.
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and GynecologySynchronous diagnosis of multicentric glioma with distinct isocitrate dehydrogenase molecular profiles: a case report.
CNS oncology[Overall survival prediction scale for patients with grade 4 brain astrocytoma].
Zhurnal voprosy neirokhirurgii imeni N. N. BurdenkoFourth ventricular pilocytic astrocytoma mimicking an arachnoid cyst: A case report and review of literature.
Surgical neurology internationalEloquent glioma resection assisted by brain connectomics: A new tool for awake neurosurgery.
Surgical neurology internationalA case report on the diagnosis and treatment of a glioneuronal tumor with ATRX alteration, kinase fusion, and anaplastic features.
Frontiers in oncologyCase Report: Novel ASAP1::BRAF fusion in a young adult with low-grade temporal lobe glioma.
Frontiers in oncologyClinical predictors of overall survival in pediatric patients with intramedullary spinal tumors: an analysis of the SEER database.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryThe Utility of Cystathionine Assessment using proton MR Spectroscopy for the Preoperative Differential Diagnosis of Adult-Type Diffuse Gliomas.
AJNR. American journal of neuroradiologyA genomically-tailored multi-agent precision medicine clinical trial for adults with recurrent glioblastoma.
Clinical cancer research : an official journal of the American Association for Cancer ResearchMagnetic resonance imaging findings of dysembryoplastic neuroepithelial tumors and low-grade astrocytomas.
Journal of the Chinese Medical Association : JCMAExtracellular vesicles-mediated communication between glioblastoma and astrocytes promotes pro-tumorigenic activation.
Medical oncology (Northwood, London, England)The Role of b-value Diffusion-weighted Imaging in Differentiating High-grade and Low-grade Brain Tumors: A Comprehensive Study with Standard b-value DWI.
Advanced biomedical researchNeuro-Ophthalmic Manifestations of Suprasellar Pilomyxoid Astrocytoma.
Neuro-ophthalmology (Aeolus Press)Heterogeneous DNA methylation and gene expression patterns underly metabolic plasticity in canine astrocytoma-derived stem-like cells.
Frontiers in oncologyEmerging minimally invasive laser and light-based therapies for glioblastoma: a systematic review.
Frontiers in oncologyIntegrated Molecular Diagnosis Paving the Way for Therapeutic Success in Recurrent Astrocytoma Treatment.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology18F-DOPA-PET and advanced MRI improve treatment response assessment in IDH1/2-mutant gliomas treated with IDH inhibitors.
Clinical cancer research : an official journal of the American Association for Cancer ResearchRecurrent distal ventriculoperitoneal shunt migration in an obese patient with high-grade glioma: A case report.
Surgical neurology internationalPediatric intramedullary spinal tumors: Pathological and clinical outcomes in a 96-case single-institution cohort study.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical NeurophysiologyCutting-edge approaches in pet imaging for gliomas: current applications for neurooncologists and the path to theranostic breakthroughs.
European journal of nuclear medicine and molecular imagingAssociation of a diffuse phenotype on MRI with shorter overall survival in patients with astrocytoma CNS WHO grades 2 and 3.
Journal of neurosurgeryStroke-Like Migraine Attacks After Radiation Therapy (SMART) Syndrome: A Case Report and Review of a Rare Delayed Complication of Cranial Irradiation.
Clinical case reportsRetrospective Analysis of Epidemiology of Intracranial and Spinal Tumor in North Western Part of India: 5-Year Observational Study of 1315 Cases.
CureusDiscovery of the MELK-Nucleostemin Axis in Glioblastoma: Implications for p53 Regulation and Tumor Progression.
Journal of microbiology and biotechnologyReasons driving choice and clinical course of patients with CNS WHO grade 3 IDH mutant glioma receiving vorasidenib after surgery: a pilot experience.
Journal of neuro-oncologyLeveraging transcriptomic, DNA methylation, and molecular alteration data to optimize the classification of IDH-mutant gliomas for therapy selection.
Frontiers in oncologyAnti-Neuroinflammatory Potential of Drospirenone in A TLR4-Driven In Vitro Model of Neuropathic Pain.
Cell journalCurrent Pharmacotherapeutic Strategies in Diffuse Gliomas: Focus on Glioblastoma, IDH-Wildtype, and Emerging Targeted Therapies for IDH-Mutant Tumors.
Pharmaceuticals (Basel, Switzerland)From Data to Decision: Integrating Bioinformatics into Glioma Patient Stratification and Immunotherapy Selection.
International journal of molecular sciencesMalignant Progression of Subependymal Giant Cell Astrocytoma-Imitating Fibrous Meningioma in a Child Carrying a Germline <italic>CHEK2</italic> Mutation.
Pathobiology : journal of immunopathology, molecular and cellular biologyPediatric low-grade epilepsy-associated tumors (LEATS): neuroimaging review and genetics update.
Pediatric radiologyTwo-Stage Surgical Management of Intramedullary Holocord Astrocytoma in an Adult: A Case Report and Literature Review.
Current oncology (Toronto, Ont.)A rare early-onset bilateral renal cysts, focal seizures in a 1-year-old male with tuberous sclerosis and No mutation identified.
Oxford medical case reportsFrom Classical to Emerging Biomarkers of Brain and Central Nervous System Tumors. An Evidence-Based Review with a Focus on Gliomas.
Cellular and molecular neurobiologyThe diagnostic value of cortical high-flow sign combined with cystathionine on 1H-MRS for prediction of 1p/19q-codeletion status in IDH-mutant adult-type diffuse glioma.
NeuroradiologyDecoding the intricacy of insular glioma-lenticulostriate artery relationship: Results from a prospective comparative study of pre and postoperative magnetic resonance angiographic evaluation.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of AustralasiaSecondary exophytic glioblastoma of the cerebellopontine angle: a case report and review of the literature.
Frontiers in oncologyGlioma chemotherapeutic resistance is tied to membrane electrophysiological properties and glycosylation.
Bioengineering & translational medicineRadiation-induced sarcoma after glioma resection in patients with Li-Fraumeni syndrome: illustrative cases.
Journal of neurosurgery. Case lessonsDesmoplastic infantile ganglioglioma/astrocytoma: Expanding the molecular and morphological spectrum with a novel BRAF fusion.
Neuro-oncology advancesConsequences of Hypoxic Events, Necrosis, and Microvascular Density, in Astrocytoma IDH-Mutant, CNS WHO Grade 4.
Medical sciences (Basel, Switzerland)Time-intensity Profiles and T1-corrected Arterial Transit Time from Multi-delay Pseudo-continuous ASL with a Variable-TR Scheme for the Characterization of Adult-type Diffuse Glioma.
Clinical neuroradiologyPediatric High-Grade Astrocytoma With Piloid Features: A Comprehensive Literature Review.
Pediatric blood & cancerSpinal deformity following surgery for paediatric intramedullary spinal cord tumours.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryGermline variants in ATM, BRCA2, other cancer predisposition and novel candidate genes are implicated in glioma risk in adult glioma patients with a familial or personal history of tumors.
Acta neuropathologicaAutophagy-Cholesterol Axis Remodeling Supports Malignant Progression and Chemoresistance in Glioma.
bioRxiv : the preprint server for biologyAssociation of CDKN2A/B Homozygous Deletion and Extent of Resection With Survival of Patients With WHO CNS5 Grade 4 Astrocytoma.
Annals of clinical and translational neurologyPhase II Study of Dabrafenib and Trametinib in Patients With Tumors With BRAFV600E Mutations: Updated Results From NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol H.
JCO precision oncologyInterleukin-9 Regulates NF-kB-Mediated Activation of Astrocytes in Multiple Sclerosis Brain.
Neurology(R) neuroimmunology & neuroinflammation[Pilocytic astrocytomas with aggressive clinical course: a single-center experience].
Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko[Differential diagnosis of high-grade astrocytic gliomas based on CD44, SOX2, and CIRBP gene expression analysis].
Zhurnal voprosy neirokhirurgii imeni N. N. BurdenkoExtremely Long-Term Glioblastoma Survival (Ten Years): A Possible Role of Immune Modulation From Pre-existing Diseases.
CureusSpectrum of spinal cord space occupying lesions: An observational perspective from Pakistan.
Pakistan journal of medical sciencesPilocytic Astrocytoma: An institutional perspective over the last decade.
Pakistan journal of medical sciencesSMARCAL1 is a targetable synthetic lethal therapeutic vulnerability in ATRX-deficient gliomas that use Alternative Lengthening of Telomeres.
Neuro-oncologyMolecular Characterization of Adult-Type Lower-Grade Glioma (WHO Grade 1-3) with Targeted Next-Generation Sequencing: A Retrospective, Single-Institution Experience.
Journal of clinical medicineHypoxia-Driven Functional Conversion of CAPE: From Anti-Inflammatory to Pro-Tumorigenic Action in the Human Astrocytoma Cell Line CCF-SSTG1.
Molecules (Basel, Switzerland)Differences in Executive Functioning Between Patients with IDH1-Mutant Oligodendroglioma and Astrocytoma Before and After Surgery.
CancersBehavioral Changes and Refractory Hypertension as the First Manifestations of Anaplastic Astrocytoma: A Case Report.
CureusPermeation of small extracellular vesicles across a human blood-brain barrier transwell model remains below particle detection limits, even under oxygen/glucose deprived conditions.
Tissue barriersT2/FLAIR Mismatch Subregion as an Independent Prognostic Biomarker in IDH-Mutant and 1p/19q Noncodeletion Astrocytoma.
AJNR. American journal of neuroradiologyFluoroscopic C2 selective nerve root block enabled with CT angiogram.
Interventional pain medicineCircumscribed low-grade astrocytoma with a synchronous occipital lesion of uncertain pathology in an adolescent with T-cell lymphoblastic lymphoma.
BMJ case reportsUnsupervised learning of metabolic fingerprints from 3D magnetic resonance spectroscopic imaging enables glioma subtype classification.
Neuro-oncology advancesMultifocal anaplastic astrocytoma mimicking primary central nervous system lymphoma: A case report.
Medicine[Polymorphous low-grade neuroepithelial tumor of the young: a molecular pathological study].
Zhonghua bing li xue za zhi = Chinese journal of pathologyAtraumatic Shoulder Dislocation Revealing a Brain Tumor: A Case Report.
CureusPRE-SURGERY BLOOD CELL RATIOS AND SURVIVAL IN PATIENTS WITH MALIGNANT GLIOMAS.
Experimental oncologyIdentification of aryl hydrocarbon receptor as a functional target that enhances astrocytic ApoE secretion.
Cell chemical biologyA congenital infant-type hemispheric glioma case with EML4::ALK fusion.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryNoninvasive MGMT-promotor methylation prediction in high grade gliomas using conventional MRI and deep learning-based segmentations.
Frontiers in neuroscienceTreatment differences in IDH-wildtype glioma - the impact of surgery and adjuvant therapy.
Journal of neuro-oncologyNew candidate gene mutations in astrocytoma with seizures.
Scientific reportsFunctionalized Carbon Dots from Bio-Based Precursors as Promising Fluorescent Probes for Cancer Cell Imaging.
International journal of molecular sciencesTumefactive Demyelinating Lesion Mimicking Low-Grade Astrocytoma with a T2/FLAIR Mismatch Sign: A Case Report and Review of the Literature.
Diagnostics (Basel, Switzerland)Single-cell and spatial transcriptome sequencing analysis reveals characteristics of a unique subpopulation in high-grade IDH-mutant astrocytoma.
Cellular oncology (Dordrecht, Netherlands)Distinct molecular profiles characterize the spontaneous growth rate of IDHmt low-grade astrocytomas and oligodendrogliomas.
Neuro-oncologyPresenting clinical and radiographic features of diffuse glioma molecular subtypes in accordance with the 2021 CNS5 WHO classification.
Neuro-oncology practiceDabrafenib in pediatric patients with BRAF V600 mutation-positive high-grade glioma: Results from a phase 1/2a single-arm study.
Neuro-oncology practiceUnusual localization of pilocytic astrocytoma at the foramen of Monro mimicking a colloid cyst: a case report and literature review.
Frontiers in oncologyNeoadjuvant PD1 blockade with laser interstitial thermal therapy for recurrent high-grade glioma.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of AustralasiaStaining the Invisible: Immunohistochemistry for Early Detection of Mismatch Repair Deficiency in Pediatric High-Grade Brain Tumors.
Pediatric blood & cancerThe contribution of methylation profiling in neuropathological diagnosis of central nervous system tumors in children, adolescent and young adults.
PathologicaSuprasellar desmoplastic infantile astrocytoma and ganglioglioma: an institutional series report and a clinical summary of this rare tumor.
Frontiers in oncologyCerebellar pilocytic astrocytoma in a patient with autism spectrum disorder and psychotic symptoms: a case report.
BMC psychiatryConcurrent and adjuvant temozolomide for 1p/19q non-co-deleted anaplastic glioma (CATNON; EORTC study 26053-22054): final and exploratory analyses of a randomised, open-label, phase 3 trial.
The Lancet. OncologyStimulating the Human Olfactory Bulb to Evoke Smell Perception: A Case Report from Awake Brain Surgery.
ORL; journal for oto-rhino-laryngology and its related specialtiesDetection of Tumor-Specific Variants in CSF of Children With Brain Tumors, Including Low-Grade and Cytology-Negative Cases.
Pediatric blood & cancerThe Fourth Ventricle, A Rare Location for Subependymal Giant Cell Astrocytoma (SEGA): A Rare Case Report.
Clinical case reportsFunctional analysis of telomere maintenance mechanisms is more informative than immunohistochemistry for ATRX mutation interpretation in Gliomas.
Acta neuropathologica communicationsMicrofluidic biosensors and devices for brain tumor diagnosis and monitoring.
Clinica chimica acta; international journal of clinical chemistryBridging Radiology and Pathology: ATRX Loss and T2-FLAIR Mismatch as Early Diagnostic and Prognostic Markers in Diffuse Gliomas.
JPMA. The Journal of the Pakistan Medical AssociationClinical Implications of Aberrant Retinoblastoma Signaling in Patients With Grade 4 IDH-Mutant Astrocytoma: A Retrospective Cohort Study.
NeurologyBenchmarking nazionale della sopravvivenza per stadio alla diagnosi dei tumori infantili in Italia (BENCHISTA-ITA): protocollo di studio.
Epidemiologia e prevenzionePrognostic Significance of MGMT Promoter Methylation Status in IDH-mutant Glioma.
Neuro-oncologyBiopsy and laser ablation as a treatment strategy for pediatric brain incidentalomas.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryCombined Hamartoma of the Retina and Retinal Pigment Epithelium: A Literature Review and Case Series.
Cureus[Vorasidenib as monotherapy in grade 2 astrocytoma or oligodendroglioma with an IDH1 R132 or IDH2 R172 mutation].
Bulletin du cancerUnpredictable Evolution of Pilocytic Astrocytoma in Adults: A Case Series and Diagnostic Challenges.
The American journal of case reportsDiffuse astrocytoma presenting with parkinsonism and gliomatosis-like infiltration.
The New Zealand medical journalExpression and Functional Role of the P2X7 Receptor in Glioma Models and Tissues: A Systematic Review.
CancersNext-Generation Sequencing Reveals a Diagnostic and Prognostic Role of the TP53 R273C Mutation in Lower-Grade, IDH-Mutant Astrocytomas.
International journal of molecular sciencesFree water elimination tractometry reveals local and remote white matter alterations in diffuse gliomas.
Journal of neuro-oncologySingle cell spatial profiling of the matrisome identifies region-specific adhesion and signaling networks in glioblastoma.
Communications biologyUnexpected [18F] Fluciclovine Uptake in Pilocytic Astrocytoma: A Pediatric Case Report.
Clinical nuclear medicine[Molecular Genetic Analysis of Childhood Brain Tumors].
No shinkei geka. Neurological surgeryPCR-based detection of Epstein-Barr virus in brain tumors of Iraqi patients with grade I-IV astrocytomas.
Human antibodiesPrognostic and predictive determinants in high-grade gliomas: integrating tumor-intrinsic biology with patient and system-level factors.
Frontiers in neurologyHow to predict progression-free survival in patients with grade 2 IDH-mutated diffuse gliomas after surgery: a long-term follow-up analysis.
Frontiers in oncologyAn atypical presentation of a pleomorphic xanthoastrocytoma in a 66-year-old woman, a case report.
Radiology case reportsMismatch Repair Deficiency in Gliomas: A Rare Insight into Microsatellite Instability and Its Diagnostic Implications.
Asian journal of neurosurgeryStereotactic radiosurgery for subependymal giant cell astrocytoma: Multi-institutional retrospective analysis of clinical and radiological outcomes.
Neurosurgical reviewSTELLAR: Phase III, Randomized, Open-Label Study of Eflornithine Plus Lomustine Versus Lomustine Alone in Patients With Recurrent Grade 3 Astrocytoma.
Journal of clinical oncology : official journal of the American Society of Clinical OncologyClinical and molecular characteristics and prognostic factors of diffuse astrocytoma, IDH-wildtype, not elsewhere classified.
Journal of neuro-oncologyDevelopment and validation of a multi-modal MRI-based deep learning framework for differentiation of intraspinal tumors (ISMF-Net).
EClinicalMedicineCase Report: FGFR1 mutation and massive chromosome loss drive malignant transformation of low-grade gliomas.
Frontiers in oncologyIsocitrate Dehydrogenase-Mutant WHO Grade 4 Astrocytoma with BCOR Alteration: Case Report.
Case reports in oncologyWounded Glioma Syndrome: A Case Report With Narrative Review.
CureusDifferential opioid receptor expression and biochemical coupling profiles on glia.
Biochemical pharmacologyEvaluating the functional status of somatostatin receptors by 99mTc-octreotide scan in patients suffering from primary brain tumors.
Revista espanola de medicina nuclear e imagen molecularPrecise diagnosis of pediatric posterior cranial fossa neoplasms based on 2.5D MRI deep learning.
Frontiers in oncologyA prognostic classification system for extent of resection in IDH-mutant grade 2 glioma: an international, multicentre, retrospective cohort study with external validation by the RANO resect group.
The Lancet. OncologyIntraoperative Language mapping in a Japanese-English-French trilingual patient with a left Temporal lobe glioma: a case report.
Brain structure & functionOptical express-biopsy of gliomas using macroscopic fluorescence lifetime imaging.
Biomedical optics expressTen years of pediatric low-grade glioma care in Kenya: Outcomes, progress, and gaps toward achieving global childhood cancer equity.
Neuro-oncology pediatrics[Molecular subtype-driven surgical concepts and clinical application in gliomas].
Zhonghua wai ke za zhi [Chinese journal of surgery]Distinguishing IDH-mutant astrocytomas from IDH-wildtype glioblastomas using qualitative and quantitative MRI features: a WHO CNS5 study.
BMC medical imagingCircumscribed Pilocytic Astrocytoma Including Pilomyxoid and Intermediate Pilomyxoid Variants - A Single Institutional, Retrospective Study.
Indian journal of surgical oncologyPediatric Diffuse Low-Grade Gliomas: Radiology, Symptoms, Treatment, and Molecular Pathways.
Neuroimaging clinics of North AmericaClinical potential of [18F]FET PET in patients with circumscribed astrocytic glioma.
European journal of nuclear medicine and molecular imagingDesigning a web-based platform for dynamic estimation of individualized conditional survival in grade 3 gliomas.
Discover oncologyNeuro-ophthalmic clues affecting the surgical approach to a brain tumor: the case of a craniopharyngioma masquerader.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryGliadel use in a pregnant patient with malignant glioma: a case report.
Frontiers in oncologyImaging features of high-grade astrocytoma with piloid features: A single center case series.
The neuroradiology journalEpidemiological characteristics and prognostic factors of high-grade brainstem glioma for all ages and the establishment of a nomogram.
Translational cancer researchPatient-Reported Outcomes, Neurocognitive Functioning, and Oncologic Results of Pencil-Beam-Scanning Proton Beam Therapy for CNS WHO G2 and G3 IDH1-Mutant Diffuse Adult Glioma: A Single Institution Experience.
International journal of radiation oncology, biology, physicsAdded value of sodium MRI in multiparametric MRI for WHO grade II astrocytoma surveillance during "watchful waiting": initial experience.
Radiologie (Heidelberg, Germany)MRI-based prediction of DNA methylation grade in IDH-mutant astrocytomas using qualitative imaging features and tumor volumetrics.
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- TERT Promoter Methylation in Glioblastoma and its Paradoxical Association with Upregulated Gene Expression.
- High-Grade Astrocytoma With Piloid Features: An Aggressive Clinicogenomic Entity Distinct From Pilocytic Astrocytoma.
- Association of CDKN2A/B and MTAP deletions in adult-type diffuse gliomas.
- Central Precocious Puberty and Optic Pathway Glioma in Children with Neurofibromatosis 1: Associations with Tumor Location, Vision, and Treatment.
- Laser interstitial thermal therapy and adjuvant pembrolizumab in recurrent high-grade astrocytoma: a Phase 1/randomized Phase 2b trial.
- Sudden death from a clinically silent right insular infarct in a patient with prior left insular astrocytoma.
- [Features of brain involvement in tuberous sclerosis patients in the Republic of Bashkortostan].
- CNS tumor type prevalence according to age group: an analysis of 21,000 cases confirmed by methylation profiling, with a focus on adolescents and young adults.
- Gasdermin as a Molecular Signature and Predictor of Adult-Type Diffuse Glioma Severity and Grading.
- Microsurgical Resection of Subependymal Giant Cell Astrocytoma: Single-Center Retrospective Analysis and Meta-Analysis.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:94(Orphanet)
- MONDO:0021636(MONDO)
- GARD:12928(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
- Q177755(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
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