Neuroblastoma (NB) é o câncer sólido mais comum em crianças, que se desenvolve fora do crânio. É um tipo de câncer infantil agressivo que surge a partir de células especiais chamadas crista neural, que fazem parte do sistema nervoso simpático.
Introdução
O que você precisa saber de cara
Neuroblastoma (NB) é o câncer sólido mais comum em crianças, que se desenvolve fora do crânio. É um tipo de câncer infantil agressivo que surge a partir de células especiais chamadas crista neural, que fazem parte do sistema nervoso simpático.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 13 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 34 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
6 genes identificados com associação a esta condição. Padrão de herança: Not applicable.
E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases (PubMed:15254018, PubMed:21988917, PubMed:22036506, PubMed:37537642, PubMed:38332367). Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion (PubMed:21988917). Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after ce
Golgi apparatus, Golgi stack membraneCytoplasmEndoplasmic reticulum
Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA (PubMed:22118463). Does not act on pri-miR21 (PubMed:22118463). The repression of let-7 expression is required for normal development and contributes to maintain the pluripoten
NucleusNucleus, nucleolusCytoplasm
Positively regulates the transcription of MYCNOS in neuroblastoma cells
Nucleus
Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum-response element
Nucleus
Central hypoventilation syndrome, congenital, 1
An autosomal dominant form of congenital central hypoventilation syndrome, a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia.
May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors
Nucleus
Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system (PubMed:11121404, PubMed:11387242, PubMed:16317043, PubMed:17274988, PubMed:30061385, PubMed:34646012, PubMed:34819673). Also acts as a key thinness protein involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a nega
Cell membrane
Medicamentos aprovados (FDA)
2 medicamentos encontrados nos registros da FDA americana.
Variantes genéticas (ClinVar)
5,074 variantes patogênicas registradas no ClinVar.
Classificação de variantes (ClinVar)
Distribuição de 5,293 variantes classificadas pelo ClinVar.
Vias biológicas (Reactome)
16 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Neuroblastoma
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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
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Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 15.778
Neuroblastoma-associated opsoclonus-myoclonus-ataxia syndrome: an important yet overlooked diagnosis in pediatric ataxia.
Este estudo destaca a Síndrome Opsoclonus-Mioclonus-Ataxia (OMAS) associada ao neuroblastoma em crianças, uma condição neurológica rara, imunomediada e frequentemente subestimada. Para pais e médicos, é vital reconhecer que a ataxia é o sintoma inicial mais comum, frequentemente acompanhada de distúrbios comportamentais e do sono, e que o opsoclonus (movimentos oculares rápidos) pode ser mal interpretado. A detecção precoce da OMAS em crianças pequenas (18-36 meses) é crucial para o diagnóstico oportuno do neuroblastoma subjacente e para um manejo adequado.
🇧🇷 traduzidoLMO1 expression in neuroblastoma cells reprograms tumor-associated macrophages to promote metastasis.
O neuroblastoma é um câncer pediátrico agressivo e frequentemente metastático. Este estudo revela que a proteína LMO1, expressa em células de neuroblastoma, reprograma macrófagos (células imunes) para que estes auxiliem na metástase. Ao induzir as células tumorais a secretar fatores que ativam os macrófagos, LMO1 promove a degradação de tecidos e a migração das células cancerígenas, oferecendo um alvo promissor para novas terapias que visem impedir a disseminação da doença.
🇧🇷 traduzidoThe Efficacy and Safety of Bevacizumab/Irinotecan/Temozolomide (BIT) for Relapsed/Refractory Neuroblastoma: The UK Children's Cancer and Leukaemia Group Experience.
Este estudo nacional britânico confirma a eficácia e tolerabilidade do tratamento BIT (bevacizumabe, irinotecano e temozolomida) para neuroblastoma recidivante ou refratário, uma condição com prognóstico geralmente desfavorável. A terapia demonstrou uma taxa de resposta objetiva de 40,6%, com melhora significativa na sobrevida livre de progressão e sobrevida global, especialmente em pacientes com doença refratária. Embora os efeitos colaterais comuns incluam anemia, febre neutropênica e diarreia, o tratamento foi geralmente bem tolerado, reproduzindo resultados promissores em um cenário de "mundo real".
🇧🇷 traduzidoRetrospective Analysis of Incidence and Etiology of Severe Infections in Children Receiving Therapy for High-Risk Neuroblastoma: A Large Single-Center Experience.
Este estudo mostra que infecções graves são uma complicação muito comum (56.5% dos pacientes) durante o tratamento de neuroblastoma de alto risco, sendo a maioria infecções na corrente sanguínea. Muitas dessas infecções estão associadas a cateteres venosos centrais, ocorrendo até mesmo em pacientes não neutropênicos, o que ressalta a importância do cuidado rigoroso com esses dispositivos. Embora frequentes, a mortalidade relacionada a essas infecções é muito baixa (1.1%), oferecendo uma perspectiva tranquilizadora para pacientes e seus familiares, ao mesmo tempo que destaca a necessidade de otimizar estratégias de prevenção focadas nos cateteres.
🇧🇷 traduzido[Correlation study between tumor location and pathological subtypes of neuroblastic tumors associated with opsoclonus myoclonus ataxia syndrome].
Objective: To analyze the correlation between the location and pathological subtypes of of neuroblastic tumors (NBT) associated with opsoclonus myoclonus ataxia syndrome (OMAS). Methods: A case-control study. Clinical data of 34 pediatric patients diagnosed with NBT complicated by OMAS (NBT-OMAS group), who were hospitalized in the Department of Pediatrics, Peking University First Hospital from January 2007 and December 2022 were collected retrospectively. The control group consisted of 34 age and sex-matched patients with NBT only (NBT-only group) admitted during the same period. Chi-square test or Fisher exact test was used to compare the distribution of tumor locations and pathological subtypes between the two groups. Cramer's V coefficient was applied to analyze the correlation between them. The outcomes of the patients were followed up. Results: The age of patients in the NBT-OMAS group was 18 (12, 28) months, while that of the NBT-only group was 20 (13, 31) months. In the NBT-OMAS group, 28 cases (82%) had tumors located in the paraspinal sympathetic chain and 6 cases (18%) in the adrenal glands. In the NBT-only group, 6 cases (18%) had tumors located in the adrenal glands and 28 cases (82%) in the paraspinal sympathetic chain, with a statistically significant difference between the two groups (χ2=10.69, P<0.01). The distribution of pathological subtypes of tumors in the NBT-OMAS group was as follows: 20 cases (59%) of ganglioneuroblastoma (GNB), 10 cases (29%) of neuroblastoma (NB), 4 cases (12%) of ganglioneuroma (GN). In the NBT-only group, NB was predominant with 21 cases (62%), GNB in 13 cases (38%), and no GN subtype was observed. There was a statistically significant difference between the two groups (χ2=8.59, P<0.01). In the NBT-OMAS group, the pathological subtype of tumors located in the adrenal gland was mainly NB, with 5 cases (5/6). For tumors located paravertebral to the thoracic and lumbar spine, the predominant subtype was GNB, with 8 cases (8/11) and 11 cases (11/13) respectively. As for tumors paravertebral to the sacral spine, the major subtype was NB, with 3 cases (3/4). In the NBT-only group, NB was the pathological subtype in 18 cases of adrenal gland tumors (18/19). For tumors paravertebral to the cervical spine, NB and GNB each accounted for 2 cases respectively (2/4). Tumors located paravertebral to the thoracic spine and paravertebral to the lumbar spine were all GNB for 5 cases (5/5), while those paravertebral to the sacral spine were all NB for 1 case (1/1). The Cramer's V coefficients of the tumor location and pathological subtype in the two groups were 0.65 and 0.81, respectively. The follow-up ended on December 31, 2023. In the NBT-OMAS group, 1 case had tumor recurrence and 1 case died due to tumor progression; both the recurrent and fatal tumors were located in the adrenal glands with the pathological subtype of NB. In the NBT-only group, 11 cases died of tumor progression, among which 8 cases had primary tumor located in the adrenal gland and with the pathological subtype of NB. Conclusions: In children with NBT-OMAS, tumors located in the paravertebral sympathetic chains are significantly more common than those in the adrenal gland, the pathological subtype of tumors was predominantly GNB. The tumor location was correlated with its pathological subtype. 目的: 分析并发眼阵挛肌阵挛共济失调综合征(OMAS)的神经母细胞肿瘤(NBT)肿瘤发生部位与病理亚型的相关性。 方法: 病例对照研究。收集2007年1月至2022年12月在北京大学第一医院儿科住院且明确诊断为NBT并发OMAS的34例患儿(NBT-OMAS组)临床资料,对照组为同期入院、年龄和性别都匹配的单纯NBT患儿34例(单纯NBT组),采用χ2 检验或Fisher确切概率法比较两组肿瘤发生部位、病理亚型的分布情况,通过Cramer′s V系数比较两者的相关性,随访患儿结局。 结果: NBT-OMAS组患儿年龄18(12,28)月龄,单纯NBT组年龄为20(13,31)月龄。NBT-OMAS组肿瘤发生于脊柱旁交感神经链者28例(82%)、肾上腺者6例(18%);单纯NBT组中发生于肾上腺和脊柱旁交感神经链者分别为19例(56%)和15例(44%),两组比较差异有统计学意义(χ2=10.69,P<0.01)。NBT-OMAS组肿瘤病理亚型分布为节细胞神经母细胞瘤(GNB)20例(59%),神经母细胞瘤(NB)10例(29%),节细胞神经瘤(GN)4例(12%);单纯NBT组病理类型主要为NB 21例(62%),GNB 13例(38%),无GN亚型,两组比较差异有统计学意义(χ2=8.59,P<0.01)。NBT-OMAS组中,6例肿瘤位于肾上腺者中5例为NB;11例位于胸椎旁者中8例为GNB;13例位于腰椎旁者中11例为GNB;4例位于骶椎旁者中3例为NB。单纯NBT组中,19例肿瘤位于肾上腺中18例为NB;4例位于颈椎旁者中NB和GNB各占2例;5例位于胸椎旁和5例位于腰椎旁者均为GNB;1例位于骶椎旁者为NB。两组肿瘤所在部位与其病理亚型的Cramer′s V系数分别为0.65、0.81。随访截至2023年12月31日,NBT-OMAS组1例肿瘤复发、1例因肿瘤进展死亡,肿瘤均位于肾上腺且病理亚型为NB;单纯NBT组有11例因肿瘤进展死亡,其中8例原发肿瘤位于肾上腺且病理亚型为NB。 结论: NBT-OMAS患儿肿瘤发生于脊柱旁交感神经链者明显多于肾上腺者;肿瘤病理亚型以GNB者为主;肿瘤发生部位与其病理亚型相关。.
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Cancer geneticsCongenital cervical neuroblastoma presenting with spontaneous tumour lysis syndrome and severe neonatal airway compromise.
BMJ case reportsCAR-NKT cell therapy for tumors: promise and progress.
Pathobiology : journal of immunopathology, molecular and cellular biologyA novel GMP-manufactured medicinal product candidate composed of NK and γδ T cells as adjunct immunotherapy for hematopoietic stem cell transplantation.
Cell transplantationRepetitive Magnetic Stimulation Modulates the Gene Expression of Neurotrophins and their Receptors in Neuroblastoma Cells.
Anticancer researchBilateral proptosis as the first manifestation in a patient with acute myeloid leukemia: Case report.
MedicineDaraxonrasib (RMC-6236) is an effective targeted therapy for RAS -mutant neuroblastoma.
bioRxiv : the preprint server for biologyEnhanced cytotoxic activity of Moringa oleifera-loaded pharmacosomes against neuroblastoma.
Nanoscale advancesmiR-137-5p-Loaded Milk-Derived Small Extracellular Vesicles Modulate Oxidative Stress, Mitochondrial Dysfunction, and Neuroinflammatory Responses in an In Vitro Alzheimer's Disease Model.
PharmaceuticsEnhancement of Cytoskeletal Tension Promotes Amyloid-β Aggregation on the Neuronal Cell Surface.
Molecules (Basel, Switzerland)GD2-Targeted Minibody-Drug Conjugates Match the Potency of IgG-Based ADCs in a Mouse Cancer Model.
International journal of molecular sciencesJurkat T-Cell Antigen-Independent Elimination of PMA-Activated Neuroblastoma Cells Is Triggered by CCL2/CCR2, Depends Upon Lipid Raft LFA1/ICAM1 Immune Synapses, Is Mediated by m-TRAIL and Is Augmented by the TrkAIII Oncoprotein.
International journal of molecular sciencesIn Vitro Anticancer Activity and In Silico Target Profiling of 5-(Piperazin-1-ylsulfonyl)-1,3-oxazole-4-carbonitriles.
International journal of molecular sciencesDiscovery of New Antioxidant Molecules Enhancing the Nrf2-Mediated Pathway: Docking Studies and Biological Evaluation.
International journal of molecular sciencesDifferential Gene Expression in Differentiated Human Neuroblastoma SH-SY5Y Cells in Response to a Cocktail of Monoamine Oxidase Inhibitors.
International journal of molecular sciencesDesign and Synthesis of Caffeine-Based Derivatives with Antioxidant and Neuroprotective Activity: In Vitro Evaluation and SwissADME Profiling.
Antioxidants (Basel, Switzerland)Lipid Peroxidation Products 4-ONE and 4-HNE Modulate Voltage-Gated Sodium Channels in Neuronal Cell Lines and DRG Action Potentials.
Antioxidants (Basel, Switzerland)Exosomes as Specific Vehicles for Delivery of Combination Therapies for Inhibiting Autophagy and Inducing Apoptosis in MYCN-Amplified Neuroblastoma Displaying Gut Dysbiosis: Current Challenges and Future Opportunities.
Brain sciencesNeuroblastoma by Stage at Diagnosis and Other Prognostic Factors: The Results of the BENCHISTA Italian Project-A Population-Based Study.
CancersNeuroblastoma Presenting as a Congenital Renal Mass in a Neonate: A Diagnostic Pitfall.
Children (Basel, Switzerland)Utilizing the Lactate Dehydrogenase-to-Albumin Ratio for Survival Prediction in Patients with Neuroblastoma.
Children (Basel, Switzerland)Established and Emerging Therapies for High-Risk Neuroblastoma.
Paediatric drugsEurycomanone from Eurycoma longifolia Jack roots regulates dopamine secretion via transsynaptic GABA signalling in differentiated SH-SY5Y human neuroblastoma cells: a transcriptomic study.
Molecular biology reportsLoss of HuD Sensitizes Neuroblastoma Cells to Palmitate-Driven Stress-Induced Premature Senescence via PPARα Downregulation and FAO Impairment.
CellsPrimary CNS Neuroblastoma, FOXR2-Activated: Clinicopathological Study of Two Cases With Immunohistochemical Characterization and Literature Review.
Neuropathology : official journal of the Japanese Society of NeuropathologyJumonji domain-containing 6 promotes the expansion of neuroblastoma stem cells by activating the wingless/ integrated pathway.
CytoJournalErastin-induced ferroptosis enhances natural killer cell anti-tumor activity and offers therapeutic potential in neuroblastoma.
Frontiers in immunologyTargeting replication stress in neuroblastoma by exploiting the synergistic potential of second generation RRM2 and CHK1 inhibitors.
Cell death & diseaseComparison of late dental sequelae in survivors of high-risk neuroblastoma treated with myeloablative high-dose chemotherapy and peripheral blood stem cell transplantation.
Oral surgery, oral medicine, oral pathology and oral radiologyInhibiting AP2M1-mediated GluA2 endocytosis by G2CT peptide ameliorates synaptic and memory deficits in Alzheimer's Disease.
NeuropharmacologyMultiplexed biomarkers dynamically detect heterogeneous residual neuroblastoma cell clone activity in the bone marrow niche.
Cancer lettersEfficacy and safety of dinutuximab beta combined with GM-CSF and isotretinoin ± chemotherapy as first-line maintenance treatment for pediatric high-risk neuroblastoma in China.
Frontiers in oncologyEnvironmental Mycotoxins and Brain Health: Protective Role of Bromelain Against Fumonisin B1 in SH-SY5Y Cells.
Environmental toxicologyLong-Term Thyroid Toxicity Burden in Children Who Received Treatment for High-Risk Neuroblastoma.
Thyroid : official journal of the American Thyroid AssociationDevelopment and validation of a clinico-histological factor-based nomogram for survival in sinonasal malignancies.
Scientific reports25-nitro-20-epi-vitamin D analogue with anti-proliferative and cytoprotective properties: Biological and pharmacological evaluation.
Experimental and molecular pathologyHuman herpesvirus 6 and non-human herpesvirus 6 limbic encephalitis in children with allogeneic stem cell transplantation: A case series.
Brain & developmentIdentification of potential clinical markers associated with prognosis of neuroblastoma.
Discover oncologyPrognostic Value of a Semi-Quantitative Score Based on 123I-MIBG SPECT/CT in Pediatric Patients With Stage 4 High-Risk Neuroblastoma After Induction Therapy.
Clinical nuclear medicineAutologous Stem Cell Transplantation for High-Risk Neuroblastoma - A Real-World Evidence from A Tertiary Cancer Care Center in Southern India.
Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood TransfusionInvestigating Microtubule-Associated Protein 2 in the Study of Postoperative Delirium.
Delirium (Bielefeld, Germany)Oleic Acid-Coated Zinc Ferrite Nanocubes: A Promising Nanocarrier for Neuroblastoma Therapy.
ACS omegaSynchronous malignant rhabdoid tumor of the kidney and adrenal neuroblastoma in an infant treated with proton beam therapy: a case report and literature review.
Frontiers in oncologyHypoxia Promotes an Adrenergic to Mesenchymal Transcriptional Program Transition in Neuroblastoma.
Clinical and translational scienceAlternative Translation Initiation in PRKN Delays the Onset of Parkinson's Disease and Offers a Therapeutic Target.
Annals of neurologyCan indocyanine green fluorescence aid operative decision making in neuroblastic tumour surgery? Early experience from a single centre.
Journal of pediatric surgeryAlpha-synuclein overexpression triggers divergent cellular responses and post-translational modifications in SH-SY5Y and ReNcell VM models.
Cellular and molecular life sciences : CMLSTargeted HDAC8 inhibition with non-hydroxamate [1,2,4]triazolo[4,3-a] quinoline compounds.
Scientific reportsLoss of function variants in HPDL impair human cortical development via alterations of mitochondrial function.
Cell death & diseaseREFCOR guidelines for sinus and nasal cavity cancer.
European annals of otorhinolaryngology, head and neck diseasesSuccessful Multimodal Treatment of SMARCA4-Deficient Sinonasal Carcinoma.
Ear, nose, & throat journalPrecision Pediatric Cancer Nanomedicine: Advancing Personalized Nano Therapies to Reduce Non-Communicable Diseases Through AI-Driven 3D-Printed Drugs.
International journal of nanomedicineDifferential inclusion formation of an aggregation-prone protein reveals differences in the proteostasis capacity of neuronal cell lines.
Biochimica et biophysica acta. Molecular cell researchThe immunosuppressive role of HLA-G+ extracellular vesicles in bone marrow of infiltrating tumors: the lesson learned from neuroblastoma and multiple myeloma.
Human immunologyNaxitamab for Relapsed/Refractory Neuroblastoma.
Journal of pediatric hematology/oncology nursingSensitive and rapid DPV detection of urinary homovanillic acid via g-C3N4@nZVI modified carbon paste sensor.
RSC advancesBreast masses in childhood: a single-center experience.
Frontiers in pediatricsThe Prognostic Value of MIBG Metastatic Patterns in Pediatric Patients with High-Risk Stage 4 Neuroblastoma Following Induction Therapy.
Academic radiologyTaxonomic characterization and toxicity assessment of strains of Gambierdiscus belizeanus from Seychelles, southwestern Indian Ocean.
Harmful algaeThe protein phosphatase 2A-B56α complex regulates N-Myc degradation in neuroblastoma.
The Journal of biological chemistry4-MEC potentially triggers CAV1 via the BDNF-TrkB signaling pathway.
Molecular and cellular neurosciencesSynthetic cannabidiol analogues exhibit lower toxicity than cannabidiol and protect against ethanol-induced apoptosis in SH-SY5Y cells.
NeurotoxicologyEvaluation of Long-Term Late Side Effects in High-Risk Neuroblastoma Patients Undergoing Autologous Bone Marrow Transplantation.
Klinische PadiatrieDinutuximab-Associated Neurotoxicity: Incidence, Presentation, Risk Factors, and Nursing Interventions.
Journal of pediatric hematology/oncology nursingBetaine alleviates neuronal impairment in glutamate-injured SH-SY5Y neuroblastoma cells via Nrf2 signaling pathway related ferroptosis.
Journal of neuroimmunologyGD2-directed NAMPT inhibition using antibody-drug conjugates in neuroblastoma.
European journal of medicinal chemistryH3K27ac-Activated lncRNA-DAPK1-IT1 Aggravated Oxidative Stress Damage Induced by Focal Cerebral Ischemia/Reperfusion via the miR-25-3p/HMGB1 Molecular Axis.
Molecular neurobiologyAntitumor effects of STING agonists on nervous system tumors via tumor-intrinsic STING-STAT1-mediated HMGN2 expression.
Cancer biology & medicineEarly Detection of Neuroblastoma Recurrence on 18F mFBG PET.
Clinical nuclear medicineMultifactorial Neuroprotective Potential of γ-Aminobutyric acid-Producing Potential Probiotics Against Stress Induced Neuronal Cell Lines.
Probiotics and antimicrobial proteinsThe gamma delta T/NK cell product GADEKILL as a novel immunotherapeutic tool for neuroblastoma patients: role of B7H6 and BTN2A1 in tumor cell killing.
Frontiers in immunologyImplications of Fatty Acid Metabolism Genes on the Prognostic Landscape of Neuroblastoma: Integration of Genetic and Immune Profiles.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSPProbing the influence of low-level laser therapy on cellular and standard proteins by light emitting diode -induced autofluorescence spectroscopy.
Journal of photochemistry and photobiology. B, BiologyMultiple endocrine neoplasia type 5: emerging evidence and clinical perspectives.
Endocrine-related cancerPersicaria hydropiper attenuates oxidative stress and reactive oxygen species, and inhibits amyloid-β/tau in SH-SY5Y cell lines via multiple pathways of Alzheimer's disease.
Journal of Alzheimer's disease : JADFirst Clinical Application of Repeated Boron Neutron Capture Therapy for Olfactory Neuroblastoma: Achieving Local Control Despite Regional Progression.
CureusSubcytotoxic Exposure to Avobenzone and Ethylhexyl Salicylate Induces microRNA Modulation and Stress-Responsive PI3K/AKT and MAPK Signaling in Differentiated SH-SY5Y Cells.
International journal of molecular sciencesNeuroblastoma in Childhood: Biological Insights, Risk Stratification, and Advances in Multimodal Therapy.
Journal of clinical medicineCharacterization of Clinical Outcomes for Patients with Relapsed High-Risk Neuroblastoma After Autologous Stem Cell Transplant and External Beam Radiotherapy.
CancersDetection and Characterisation of Circulating Tumour Cell Clusters in Neuroblastoma.
CancersYAP1 Enhances Mesenchymal-Type Gene Expression in Human Adrenergic-Type Neuroblastoma Cells.
CancersOrthopedic manifestations as presenting symptoms in children with neuroblastoma: a retrospective case series and clinical review.
Journal of orthopaedic surgery and researchAcetyl-11-keto-β-boswellic acid attenuates tau oligomer-induced neurotoxicity in neuroblastoma cell model.
BMC neuroscienceGender Equity in pediatric surgical care in Central and South Asia: A systematic review and meta-analysis.
Journal of pediatric surgeryCircadian rhythm heterogeneity modulates drug response variations in neuroblastoma models.
Cell reportsMutated FGFR1 is an oncogenic driver and therapeutic target in high-risk neuroblastoma.
The Journal of clinical investigationHistotripsy-initiated immune response synergizes with chemotherapy in a neuroblastoma murine model.
bioRxiv : the preprint server for biologyQuantifying Mechanical Strain-Induced Membrane Damage in Early Neuronal Cells Using an In Vitro Traumatic Brain Injury Model.
Bio-protocolNeuroD1-USP1-MYCN axis drives tumor progression in neuroblastoma.
Journal of translational medicineA phase II trial of naxitamab plus stepped-up dosing of GM-CSF for patients with high-risk neuroblastoma in second or later complete remission.
International journal of cancerSpatially Resolved Sequential Activation of Allosteric DNA for In Vivo Dual-Target Detection within Mitochondria: A Strategy to Visualize of Drug-Resistant Neuroblastoma.
ACS sensorsTherapeutic targeting of cancer stem cell-specific surface glycans and glycoproteins.
Discover oncologyO-GlcNAcylation expression predicts a favorable prognosis and mitigates malignant phenotypes via MYCN suppression in neuroblastoma.
Molecular and cellular pediatricsMed13 is involved in the radial migration and contralateral projection of cortical neurons via PlxnA4.
Communications biologyNeuroprotective and antioxidant properties of Polygala virgata fractions in a 6-hydroxydopamine-induced neurotoxicity model.
Journal of ethnopharmacologyAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Neuroblastoma-associated opsoclonus-myoclonus-ataxia syndrome: an important yet overlooked diagnosis in pediatric ataxia.
- LMO1 expression in neuroblastoma cells reprograms tumor-associated macrophages to promote metastasis.
- The Efficacy and Safety of Bevacizumab/Irinotecan/Temozolomide (BIT) for Relapsed/Refractory Neuroblastoma: The UK Children's Cancer and Leukaemia Group Experience.
- Retrospective Analysis of Incidence and Etiology of Severe Infections in Children Receiving Therapy for High-Risk Neuroblastoma: A Large Single-Center Experience.
- [Correlation study between tumor location and pathological subtypes of neuroblastic tumors associated with opsoclonus myoclonus ataxia syndrome].
- Targeting LY6E Inhibits Neuroblastoma Progression and Suppresses M2 Macrophage Polarization.
- Therapeutically relevant rimonabant exposure drives epigenetic remodeling in neuronal cells and rat brain tissue.
- The Paracrine TAC1-TACR1 Signaling Promotes Endothelial Senescence and Metastatic Progression in Neuroblastoma.
- L-BMAA induces neurotoxicity through AMPK/Akt-TSC1/2-mTOR-mediated mitophagy dysregulation and apoptosis.
- Genetic association analysis of lnc-AMFR-1:1 rs4784659 C > T and neuroblastoma susceptibility in Chinese pediatric patients.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:635(Orphanet)
- MONDO:0005072(MONDO)
- GARD:7185(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
- Q938205(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
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