Síndrome é um conjunto de sinais e sintomas que define as manifestações clínicas de uma ou várias doenças ou condições clínicas, independentemente da etiologia que as diferencia. Por exemplo, a Síndrome de Raynaud pode ser uma manifestação de várias patologias ou mesmo considerado idiopático quando o estudo do paciente não encontra uma causa plausível. Também a Síndrome meníngea pode ser o reflexo de patologias muito diferentes como hemorragia cerebral, meningite purulenta, tuberculose meníngea ou uma simples meningite vírica. Se os sinais são exclusivamente laboratoriais e não clínicos chama-se de síndrome laboratorial para realçar o fato de que não há sinais ou sintomas clínicos que evidenciem doença.
Introdução
O que você precisa saber de cara
Síndrome hipereosinofílico idiopática é uma doença rara caracterizada por eosinofilia persistente e envolvimento multissistêmico, podendo manifestar-se com colite, hipotonia axial, defeitos ventilatórios restritivos e fibrose endocárdica. A trombose venosa é uma complicação frequente.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Entender a doença
Do básico ao detalhe, leia no seu ritmo
Preparando trilha educativa...
Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 36 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 90 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
1 gene identificado com associação a esta condição. Padrão de herança: Not applicable.
Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal dev
Cell membraneCell projection, ciliumGolgi apparatus
Variantes genéticas (ClinVar)
198 variantes patogênicas registradas no ClinVar.
Classificação de variantes (ClinVar)
Distribuição de 170 variantes classificadas pelo ClinVar.
Vias biológicas (Reactome)
13 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Síndrome hipereosinofílico idiopático
Selecione um estado ou use sua localização para ver resultados.
Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
🟢 Recrutando agora
1 pesquisa recrutando participantes. Converse com seu médico sobre a possibilidade de participar.
Outros ensaios clínicos
5 ensaios clínicos encontrados, 1 ativos.
Publicações mais relevantes
Idiopathic Hypereosinophilic Syndrome Presenting as Acute Encephalopathy Secondary to Watershed Ischemic Stroke.
Idiopathic Hypereosinophilic Syndrome in a Child- Rare Disease with Fulminant Clinical Course.
Laboratory Aspects and Diagnostic Challenges in a Case of Hypereosinophilic Syndrome.
Hypereosinophilia is defined by a persistent increase in eosinophil levels and can lead to multi-organ damage with highly variable symptoms. The most common manifestations involve the skin, lungs, and gastrointestinal tract, while cardiac and neurological complications can be particularly severe and sometimes fatal. Within this context, we describe the case of a 35-year-old woman with hypereosinophilic syndrome (HES), whose symptoms began during pregnancy. Three months after giving birth, she contracted SARS-CoV-2, which resolved without complications. However, shortly thereafter, laboratory tests revealed marked leukocytosis accompanied by a rapid clinical deterioration. At admission, the patient displayed severe hypereosinophilia associated with systemic inflammation, liver injury, myocardial necrosis, and multi-organ involvement affecting the kidneys, brain, heart, and lungs. As her neurological condition worsened, she required admission to the intensive care unit, where she unfortunately died four days later. The aim of this case report is to raise awareness among clinicians and laboratory professionals about the crucial role of the laboratory finding in assessing disease severity and guiding the diagnostic challenges of idiopathic syndrome (I-HES). The exclusion of secondary causes confirmed the idiopathic nature of the condition. Finally, the case highlights the importance of early recognition of unexplained eosinophilia and systemic symptoms, as timely intervention may be life-saving in rapidly progressive presentations.
Real-world outcomes after anti-IL-5/anti-IL-5Rα treatment for hypereosinophilic syndrome: Systematic literature review.
Anti-IL-5/anti-IL-5 receptor alpha (anti-IL-5/anti-IL-5Rα) treatments have potential to improve outcomes in hypereosinophilic syndrome (HES), as demonstrated in clinical trials. We sought to understand the real-world outcomes of anti-IL-5/anti-IL-5Rα treatments in patients with HES. This systematic literature review searched English-language articles (November 4, 2015, to October 31, 2023) and conference abstracts (January 1, 2021, to October 31, 2023) from MEDLINE/Embase and select conferences for publications containing outcomes for patients with HES receiving anti-IL-5 (mepolizumab [approved], reslizumab) or anti-IL-5Rα (benralizumab) treatment in the real world. Meta-analyses and clinical trials were excluded. Outcomes included treatment response, blood eosinophil (bEOS) counts, and oral corticosteroid (OCS) receipt. No formal bias assessment was conducted. Five cohort studies (192 participants) and 55 case reports (70 participants) were identified. In cohort studies, median age was 44.0 to 61.8 years; 33.3% to 62.9% were female, and 45.5% to 100% had idiopathic HES. Mean (standard deviation) age in case reports (n = 68/70) was 38.5 (23.7) years; 40.0% (n = 28/70) were female, and 67.2% (n = 39/58) had idiopathic HES. Across 4 cohort studies, most patients had reduced or no HES flares after mepolizumab or benralizumab. In patients from case reports, 13 had HES flares (mepolizumab, n = 12/54; benralizumab, n = 1/13) after anti-IL-5/anti-IL-5Rα initiation. Mean bEOS counts were reduced by 53.0% to 100% across 3 cohort studies and by 95.0% in case reports. Of those receiving benralizumab or mepolizumab, OCS dose was reduced in 49.0% to 100% of patients from cohort studies, and by ≥50% in 29 of 70 patients from case reports. Real-world anti-IL-5/anti-IL-5Rα therapy in HES is associated with fewer flares as well as reductions in bEOS counts and OCS dose, although confirmatory studies in larger populations are needed.
Clinical Utility of 18 F-FDG PET/CT in Patients With Hypereosinophilia : An 11-year Single-center Experience.
Hypereosinophilia (HE) is a rare disease with complex and diverse causes. Therapeutic strategies for HE differ because of its diverse causes, demanding advanced diagnostic tools for accurate assessment. This study evaluated the role of 18 F-fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) in determining the etiology of HE. This retrospective single-center study consecutively included 78 patients with HE who underwent 18 F-FDG PET/CT examinations between 2011 and 2022. The diagnostic value of 18 F-FDG PET/CT in identifying the etiology of HE was assessed. Logistic regression analyses were conducted to determine the clinical and laboratory factors associated with 18 F-FDG PET/CT outcomes. Seventy-eight patients aged 44.58±17.01 years had different conditions: infectious diseases, n=9 [11.54%]; noninfectious inflammatory diseases, n=23 [29.49%]; solid tumors or hematological malignancies, n=16 [20.51%]; lymphocyte-variant HE, n=1 [1.28%]; and idiopathic HE or idiopathic hypereosinophilic syndrome, n=29 [37.18%]. 18 F-FDG PET/CT was used to identify the etiology in 48 patients (61.54%, true positive), whereas secondary causes were ruled out in 21 patients (26.92%), leading to a diagnosis of idiopathic HE. 18 F-FDG PET/CT achieved a diagnostic sensitivity of 92.31%, specificity of 80.77%, and accuracy of 88.46%. The presence of symptoms was positively correlated with true-positive PET/CT results (odds ratio: 2.940, 95% CI: 1.073-8.055), whereas immunoglobulin E level exhibited no association. 18 F-FDG PET/CT showed high sensitivity and accuracy in identifying the etiology of HE, making it a valuable tool for assessing elevated eosinophil counts.
Publicações recentes
Coronary vasospasm in a patient with RUNX1 mutation in eosinophilic leukemia and hypereosinophilic syndrome: A case report.
Idiopathic Hypereosinophilic Syndrome in a Patient with End-Stage Renal Disease.
Aortic Valve Annular Parameters in Idiopathic Hypereosinophilic Syndrome-A Detailed Investigation from the Three-Dimensional Speckle-Tracking Echocardiographic MAGYAR-Path Study.
Idiopathic Hypereosinophilic Syndrome Presenting as Acute Encephalopathy Secondary to Watershed Ischemic Stroke.
Idiopathic Hypereosinophilic Syndrome in a Child- Rare Disease with Fulminant Clinical Course.
📚 EuropePMC419 artigos no totalmostrando 196
Idiopathic Hypereosinophilic Syndrome Presenting as Acute Encephalopathy Secondary to Watershed Ischemic Stroke.
Annals of Indian Academy of NeurologyIdiopathic Hypereosinophilic Syndrome in a Child- Rare Disease with Fulminant Clinical Course.
Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood TransfusionLaboratory Aspects and Diagnostic Challenges in a Case of Hypereosinophilic Syndrome.
CureusFulminant Idiopathic Hypereosinophilic Syndrome Presenting with Cardiac, Neurologic and Haematologic Involvement.
European journal of case reports in internal medicineReal-world outcomes after anti-IL-5/anti-IL-5Rα treatment for hypereosinophilic syndrome: Systematic literature review.
The journal of allergy and clinical immunology. GlobalRefractory erythroderma in idiopathic hypereosinophilic syndrome: A case treated with mepolizumab and abrocitinib.
SAGE open medical case reportsAcute multisystemic thromboembolism manifesting as cerebral infarction, myocardial injury, and quadriparesis: a novel triad of idiopathic hypereosinophilic syndrome.
Frontiers in medicineHypereosinophilic syndrome with pulmonary and hepatic involvement mimicking autoimmune disease.
Oxford medical case reportsClinical Utility of 18 F-FDG PET/CT in Patients With Hypereosinophilia : An 11-year Single-center Experience.
Clinical nuclear medicineIdiopathic hypereosinophilic syndrome complicated by computed tomography-negative cerebral infarction, strangulated intestinal obstruction, and hepatic portal venous gas: a case report of multi-system involvement.
Quantitative imaging in medicine and surgeryIdiopathic hypereosinophilic syndrome associated with multivessel coronary artery ectasia: a case report.
The Pan African medical journalPanuveitis Associated With Idiopathic Hypereosinophilic Syndrome.
Journal of vitreoretinal diseasesIdiopathic hypereosinophilic syndrome: Potential pathologic somatic gene variants identified by exome sequencing.
The journal of allergy and clinical immunology. GlobalIdiopathic hypereosinophilic syndrome in a female Sprague Dawley rat.
Laboratory animalsA Clinical Conundrum in Patients With a Common Clinical Spectrum but Rare Differentials: Hyper-Immunoglobulin E Syndrome and Idiopathic Eosinophilia.
CureusIdiopathic Hypereosinophilic Syndrome Presenting As Eosinophilic Ascites and Pleural Effusion in an Elderly Male: A Rare Clinical Manifestation.
CureusBenralizumab in a Patient With Refractory Eosinophilic Endocarditis.
Journal of medical cases[Efficacy and survival outcomes of patients with lymphocytic variant hypereosinophilic syndrome].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhiEosinophilic lung disease with a tumour lysis-like syndrome.
BMJ case reportsCase Report: Idiopathic hypereosinophilic syndrome presenting with gastrointestinal involvement mimicking IBD: a diagnostic challenge.
Frontiers in medicine[A Case of Idiopathic Hypereosinophilic Syndrome Treated with Mepolizumab].
Acta medica portuguesaClinical and immunological biomarkers in hypereosinophilic syndrome: the second step after diagnostic algorithms.
Frontiers in medicineAn Uncommon Case of Non-Specific Interstitial Pneumonia (NSIP) Associated With Idiopathic Hypereosinophilic Syndrome (HES) Reversed by Mepolizumab.
Respirology case reportsEosinophilia and gastrointestinal symptoms in Immunosuppression: a classic but overlooked diagnosis.
Revista espanola de enfermedades digestivasComplete hematological response with imatinib mesylate in a corticosteroid refractory idiopathic hypereosinophilic syndrome in person living with HIV: A case report.
International journal of STD & AIDSBiologic Agents in Idiopathic Hypereosinophilic Syndrome.
Pharmaceuticals (Basel, Switzerland)Insights from comparison of serum IgG4 between T2-eosinophilic asthma and eosinophilic granulomatosis with polyangiitis/idiopathic hypereosinophilic syndrome.
Clinical and experimental rheumatologyRefractory Idiopathic Hypereosinophilic Syndrome Presenting with Myocarditis and Responding to Imatinib: A Case Report.
Saudi journal of medicine & medical sciences68 Ga-FAPI PET/CT in a Patient With Multiple Aneurysms Due to Idiopathic Hypereosinophilic Syndrome.
Clinical nuclear medicineIdiopathic Hypereosinophilic Syndrome With Cutaneous Manifestations: A Case Report.
CureusPulmonary Arterial Hypertension Associated With Idiopathic Hypereosinophilic Syndrome: Importance of Eosinophilia Control With Steroid Therapy.
CJC openMyocarditis with neurological and dermatological involvement in idiopathic Hypereosinophilic syndrome: Case report.
Radiology case reportsWells' Syndrome Associated With Idiopathic Hypereosinophilic Syndrome in a Child: A Case Report.
Cureus[The evaluation of a patient with eosinophilia].
Nederlands tijdschrift voor geneeskundeFulminant eosinophilic myocarditis and refractory ventricular arrhythmias requiring mechanical circulatory support: a case report.
European heart journal. Case reportsHyper eosinophilic diseases - diagnosis and therapeutic approach - practical position of the Polish working group.
Otolaryngologia polska = The Polish otolaryngologyChronic eosinophilic leukaemia-Not otherwise specified: Clinical features, genomic insight and therapeutic strategies.
British journal of haematologyA Storm of Polyserositis: Unravelling Multisystem Effusions in Hypereosinophilic Syndrome.
CureusMultiple Cerebral Infarcts and Encephalopathy as the First Clinical Manifestations of Hypereosinophilic Syndrome: A Case Report and Narrative Review.
Pulse (Basel, Switzerland)A rare case of PDGFRA-positive chronic eosinophilic leukemia.
Indian journal of pathology & microbiologyA Challenging Case of Idiopathic Hypereosinophilic Syndrome: An Itching in the Brain.
CureusSuccessful novel use of dupilumab for gastrointestinal involvement of idiopathic hypereosinophilic syndrome: case report and review of the literature.
Clinical journal of gastroenterologyProbable idiopathic hypereosinophilic syndrome: A case report of severe multi-organ eosinophilic involvement in a young male presenting with heart failure.
SAGE open medical case reportsDiagnosis of rare Loffler endocarditis by cardiac ultrasound: a case report and literature review.
Medical ultrasonographyA case report of Löffler's endocarditis with right ventricular outflow obstruction in idiopathic hypereosinophilic syndrome: timely surgical intervention is crucial.
European heart journal. Case reportsRadioclinical Profile of Eosinophilic Lung: A Case Series.
CureusAn Unusual Case of Immune Complex-Mediated Membranoproliferative Glomerulonephritis as Renal Manifestation of Idiopathic Hypereosinophilic Syndrome: A Case Report and Literature Review.
Medicines (Basel, Switzerland)Idiopathic hypereosinophilic syndrome presenting with stroke.
Clinical neuropathologyPrognostic factors of idiopathic hypereosinophilic syndrome: A nationwide survey in Japan.
British journal of haematologyCardiac Magnetic Resonance Imaging Used to Determine a Rare Etiology of a Layered Left Ventricular Apical Thrombus.
CureusNot just for lymphoid cells: the role of the noncanonical NF-κB signaling pathway in early and late myelopoiesis with a focus on hypereosinophilic disorders.
Journal of leukocyte biologyMultimodality imaging of eosinophilic myocarditis (loeffler's endocarditis) in a patient with idiopathic hypereosinophilic syndrome.
The international journal of cardiovascular imagingHypereosinophilic syndrome: a rare cause of ST-elevation myocardial infarction and thrombus formation on the aortic valve.
BMJ case reportsConcurrent Challenges in Idiopathic Hypereosinophilic Syndrome Complicating Beta-Thalassemia Major: A Case Report.
CureusWorld Health Organization and International Consensus Classification of eosinophilic disorders: 2024 update on diagnosis, risk stratification, and management.
American journal of hematologyIdiopathic Hypereosinophilic Syndrome in a Professional Athlete.
Annals of clinical and laboratory scienceEosinophilia and wheeze: thinking beyond asthma.
Breathe (Sheffield, England)Co-occurrence of Idiopathic Hypereosinophilic Syndrome in End-Stage Renal Disease Patients Undergoing Maintenance Hemodialysis.
CureusETV6::ABL1-Positive Myeloid Neoplasm: A Case of a Durable Response to Imatinib Mesylate without Additional or Previous Treatment.
International journal of molecular sciencesSevere Idiopathic Hypereosinophilic Syndrome with Eosinophilic Cholecystitis in a Child Treated with Mepolizumab.
Indian journal of pediatricsCase Study: Personalized Oral Low-dose Naltrexone Titration for Pain Management.
International journal of pharmaceutical compoundingAn 85-Year-Old Man with Fever, Dyspnea, and Dry Cough Diagnosed with Idiopathic Hypereosinophilic Syndrome, Successfully Treated with High-Dose Corticosteroids.
The American journal of case reportsA Rare Presentation of Hypereosinophilic Syndrome With Loffler's Endomyocarditis, Encephalopathy, and Multiple Thromboembolic Strokes.
CureusHypereosinophilic Syndrome Endocarditis With Severe Biventricular Failure Complicated by Sepsis: A Challenging Case.
CureusPericardial Effusion and Progressive Bilateral Effusion as Rare Presentations of Idiopathic Hypereosinophilic Syndrome.
CureusSuccessful use of mepolizumab for severe hypereosinophilic vasculitis with c-ANCA positivity in a previously healthy 7-year-old boy.
The journal of allergy and clinical immunology. GlobalLow-dose anti-IL 5 treatment in idiopathic hypereosinophilic syndrome: towards a precision medicine approach for remission maintenance.
Orphanet journal of rare diseasesA case of atypical IgG4-related disease presenting hypereosinophilia, polyneuropathy, and liver dysfunction.
Modern rheumatology case reportsIdiopathic Hypereosinophilic Syndrome Presenting with Recalcitrant Oral and Genital Ulcers Responding Well to Thalidomide.
Indian dermatology online journalIdiopathic hypereosinophilic syndrome presenting as capsular warning syndrome: A case report and literature review.
MedicineIdiopathic hypereosinophilic syndrome presenting as cardiac tamponade and multiorgan dysfunction.
BMJ case reportsIdiopathic hypereosinophilic syndrome with hepatic sinusoidal obstruction syndrome: A case report and literature review.
World journal of gastrointestinal surgeryChronic Oro-Genital Ulcerations as a Presenting Feature of Chronic Eosinophilic Leukemia: A Case Report.
Indian dermatology online journalThe First Definition of Pulmonary Component of Hypereosinophilic Syndrome: Bronchial Casts.
Thoracic research and practiceIdiopathic Hypereosinophilic Syndrome: A Case Report.
CureusCase Report: Off-label treatment of idiopathic hypereosinophilic syndrome with Omalizumab.
Frontiers in pharmacologyHypereosinophilic syndrome with cutaneous manifestations successfully treated with Dupilumab as a sole agent: A case report.
The Australasian journal of dermatologyRevisiting a case of idiopathic hypereosinophilic syndrome with novel molecular techniques identifies a second case of a myeloid/lymphoid neoplasm with a SART3::PDGFRB fusion.
British journal of haematologyCryptococcal Neoformans and Varicella Zoster Meningitis in a Patient With Selective Innate Immunodeficiency: A Case Report.
CureusGiant Coronary Artery Aneurysm with Thrombosis Complicated in a Patient with Idiopathic Hypereosinophilic Syndrome.
Yonsei medical journalIdiopathic Hypereosinophilia: A Multicenter Retrospective Analysis.
Journal of asthma and allergyCerebral watershed infarctions as a presentation of idiopathic hypereosinophilic syndrome: a case report.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical NeurophysiologyThe role of flexible bronchoscopy in the diagnostic pathway of children with unexplained peripheral eosinophilia.
Pediatrics international : official journal of the Japan Pediatric SocietyIntermittent Soft-Tissue Tumor Enlargement in Episodic Angioedema With Eosinophilia Syndrome.
The American Journal of dermatopathologyEosinophilic Myocarditis Presenting as Cardiac Tamponade: A Diagnostic Challenge.
European journal of case reports in internal medicineAnesthetic Management of a Large Right Ventricular Mass due to Idiopathic Hypereosinophilic Syndrome in a Patient Undergoing Cardiac Surgery, a Case Report.
Seminars in cardiothoracic and vascular anesthesiaCase report: Application of non-VKA oral anticoagulants in patient of idiopathic hypereosinophilic syndrome with intracardiac thrombus.
Frontiers in pharmacologyUpdates on eosinophilic disorders.
Virchows Archiv : an international journal of pathologyAcute exacerbation of idiopathic hypereosinophilic syndrome following asymptomatic coronavirus disease 2019: a case report.
Journal of medical case reportsThe Diagnostic Challenge of Eosinophilic Granulomatosis With Polyangiitis Presenting as Acute Eosinophilic Myocarditis: Case Report and Literature Review.
Frontiers in cardiovascular medicineA novel treatment workflow of idiopathic hypereosinophilic syndrome: a single-center retrospective cohort study.
Chinese medical journalRare Case of a Young Male Presented with Abdominal Pain, Solid Colon Tumors, and Eosinophilia, Followed by Tremendous Thromboembolic Complications and Eventually Diagnosed with Idiopathic Hypereosinophilic Syndrome.
Case reports in medicineA Diagnosis of Idiopathic Hypereosinophilic Syndrome With Skin Involvement in a Patient Presenting With Lymphadenopathy and Rash.
CureusTumefactive eosinophil-rich non-granulomatous small vessel vasculitis in the cerebrum in a patient with idiopathic hypereosinophilic syndrome.
Neuropathology : official journal of the Japanese Society of NeuropathologyIdiopathic Hypereosinophilic Syndrome Associated With Pulmonary Hypertension in an Infant.
Journal of pediatric hematology/oncologyHyperleucocytosis as an unusual presentation of hypereosinophilic pneumonitis with acute respiratory distress syndrome.
SAGE open medical case reportsA retrospective cohort study of patients with eosinophilia referred to a tertiary centre.
Danish medical journalThe Neutrophil/Lymphocyte Ratio is an Independent Predictor of All-Cause Mortality in Patients with Idiopathic Hypereosinophilic Syndrome.
Journal of inflammation researchIdiopathic hypereosinophilic syndrome with eosinophilic cellulitis-like cutaneous involvement treated with mepolizumab and dapsone.
JAAD case reportsClinical analysis of hypereosinophilic syndrome first presenting with asthma-like symptoms.
Annals of medicineEosinophilic vasculitis as a manifestation of idiopathic hypereosinophilic syndrome.
The Journal of dermatologyIdiopathic Hypereosinophilic Syndrome Presenting With Embolic Stroke.
CureusA Rare Manifestation of IgG4-Related Disease and Concurrent Idiopathic Hypereosinophilic Syndrome as Extensive Gastrointestinal Lesions: A Case Report.
Inflammatory bowel diseasesEosinophilia characterized by a rare CCT6B mutation and responsive to tyrosine kinase inhibition: Case report and literature review.
Leukemia research reportsIdiopathic hypereosinophilic syndrome presenting as mononeuritis multiplex. Lessons learned after 18-months of follow-up.
NeurologiaAcute Liver Failure Due to Hypereosinophilic Syndrome Accompanied by Duodenal Perforation.
Internal medicine (Tokyo, Japan)World Health Organization-defined eosinophilic disorders: 2022 update on diagnosis, risk stratification, and management.
American journal of hematologyRecurrent prosthetic valve dysfunction in a patient with idiopathic hypereosinophilic syndrome: A case report and literature review.
Journal of cardiac surgeryEosinophilic Myocarditis: When Allergies Attack the Heart!
Cardiology in reviewRenal Involvement as Rare Acute Tubulointerstitial Nephritis in a Patient with Eosinophilic Disorder Treated with Early Add-on Administration of Mepolizumab.
Internal medicine (Tokyo, Japan)Idiopathic hypereosinophilic syndrome with intracardiac atypical linear-shaped and floating thrombus presenting as embolic cerebral infarction.
Journal of cardiology casesInvestigating Febrile Polyserositis: An Unusual Case of Idiopathic Hypereosinophilic Syndrome.
European journal of case reports in internal medicine[Multiple cerebral infarctions in the deep perforator regions in a case of idiopathic hypereosinophilic syndrome].
Rinsho shinkeigaku = Clinical neurologyPurtscher-like retinopathy associated with idiopathic hypereosinophilic syndrome.
Journal francais d'ophtalmologieIdiopathic Hypereosinophilic Syndrome with Multiple Organ Involvement.
Case reports in oncologyIdiopathic hypereosinophilic syndrome in hemodialysis patients: Case reports.
MedicineHypereosinophilic syndrome with multiorgan involvement: an interdisciplinary work-up.
BMJ case reportsFavorable Response to Interferon-α in Infantile-onset Idiopathic Hypereosinophilic Syndrome Complicated by Status Epilepticus During Treatment.
Journal of pediatric hematology/oncologyA systems biology approach for defining the potential molecular framework of idiopathic hypereosinophilic syndrome with cutaneous involvement.
Biochemical and biophysical research communicationsClinical and morphologic spectrum of renal involvement in idiopathic hypereosinophilic syndrome.
Clinical and experimental nephrologyA flare up of idiopathic hypereosinophilic syndrome due to COVID-19.
European heart journalIdiopathic hypereosinophilic syndrome: A rare diagnosis in children.
Clinical case reportsIdiopathic hypereosinophilic syndrome in remission with benralizumab treatment after relapse with mepolizumab.
Respirology case reportsAcute progressive stroke with middle cerebral artery occlusion caused by idiopathic hypereosinophilic syndrome: a case report.
BMC neurologySuccessful treatment of idiopathic hypereosinophilic syndrome with benralizumab in a pediatric patient.
The journal of allergy and clinical immunology. In practiceThe role of eosinophil morphology in distinguishing between reactive eosinophilia and eosinophilia as a feature of a myeloid neoplasm.
British journal of haematologyColon perforation due to cytomegalovirus infection in a patient with idiopathic hypereosinophilic syndrome: a case report.
BMC gastroenterologyIdiopathic hypereosinophilic syndrome associated with rapid progression of cardiac, pulmonary and skin infiltration.
Cardiovascular journal of Africa[Diagnostic workup in front of an hypereosinophilia in 2020].
Annales de biologie cliniqueAn unusual presentation of Idiopathic hypereosinophilic syndrome.
Journal of thrombosis and thrombolysisIdiopathic hypereosinophilic syndrome with formation of multiple liver mass lesions.
Clinical journal of gastroenterologyAscites in a young male: idiopathic FIP1L1-PDGFRA-negative hypereosinophilic syndrome.
JRSM openIdiopathic hypereosinophilic syndrome presenting as monoplegia.
BMJ case reportsIdiopathic hypereosinophilic syndrome with cutaneous necrosis and multiorgan embolism.
JAAD case reportsHypereosinophilic dermatitis: generalised lichenification and gyrate erythema as the sole manifestation of idiopathic hypereosinophilic syndrome.
BMJ case reportsFamilial clustering of hypereosinophilic diseases treated with mepolizumab: a case report from Japan.
European annals of allergy and clinical immunologyLoeffler Endocarditis in Idiopathic Hypereosinophilic Syndrome Demonstrated by Magnetic Resonance Imaging Effectively Treated by Corticosteroids.
Acta Cardiologica SinicaAcute kidney injury secondary to thrombotic microangiopathy associated with idiopathic hypereosinophilic syndrome: a case report and review of the literature.
Journal of medical case reportsSkin-limited idiopathic hypereosinophilic syndrome presenting with retiform purpura.
JAAD case reportsWorld Health Organization-defined eosinophilic disorders: 2019 update on diagnosis, risk stratification, and management.
American journal of hematologyLong-term Follow-up of Severe Eosinophilic Hepatitis: A Rare Presentation of Hypereosinophilic Syndrome.
Rambam Maimonides medical journalTeaching NeuroImages: Multifocal cerebral infarcts as a presentation of idiopathic hypereosinophilic syndrome.
NeurologyA case report of Löffler endocarditis in idiopathic hypereosinophilic syndrome: recovery is possible.
European heart journal. Case reportsIdiopathic Hypereosinophilic Syndrome in an Elderly Female: A Case Report.
The American journal of case reportsIdiopathic hypereosinophilic syndrome presenting with multiple organ damage: A case report.
Medicine[Chronic myeloid leukemia presenting with marked eosinophilia].
[Rinsho ketsueki] The Japanese journal of clinical hematologyIdiopathic hypereosinophilic syndrome with cutaneous involvement: a comparative review of 32 cases.
BMJ case reportsEyelid Swelling and Subconjunctival Infiltration as Ophthalmic Manifestations in a Child with Idiopathic Hypereosinophilic Syndrome.
Korean journal of ophthalmology : KJOAcute pulmonary embolism and deep vein thrombosis secondary to idiopathic hypereosinophilic syndrome.
Respiratory medicine case reportsChurg-Strauss Syndrome Presenting as Acute Necrotizing Eosinophilic Myocarditis: Concise Review of the Literature.
Current hypertension reviewsA multimodality work-up of patients with Hypereosinophilia.
American journal of hematologyIdiopathic hypereosinophilic syndrome with pulmonary hypertension.
Pulmonary circulationDysphonia and dyspnea in idiopathic hypereosinophilic syndrome treated with Mepolizumab.
Respiratory medicine case reportsThe Diagnostic Work-Up of Hypereosinophilia.
Pathobiology : journal of immunopathology, molecular and cellular biology[Hypereosinophilic syndrome associated with cardiac involvement].
The Pan African medical journalA Case of Pulmonary Hypertension Associated with Idiopathic Hypereosinophilic Syndrome.
International heart journalFatal Outcome of Imatinib in a Patient with Idiopathic Hypereosinophilic Syndrome.
Case reports in oncological medicineA young female presenting with heart failure secondary to eosinophilic myocarditis: a case report and review of the literature.
BMC research notesSevere Multi-Organ Failure and Hypereosinophilia: When to Call It "Idiopathic"?
Journal of investigative medicine high impact case reports[Portal vein thrombosis associated with idiopathic hypereosinophilic syndrome].
[Rinsho ketsueki] The Japanese journal of clinical hematology[A case report of idiopathic hypereosinophilic syndrome with pulmonary embolism].
Zhonghua nei ke za zhiThe right atrium in idiopathic hypereosinophilic syndrome : Insights from the 3D speckle tracking echocardiographic MAGYAR-Path Study.
HerzEosinophilic Myocarditis.
The American journal of the medical sciencesIdiopathic hypereosinophilia is clonal disorder? Clonality identified by targeted sequencing.
PloS one[Pediatric idiopathic hypereosinophilic syndrome with pulmonary embolism: a case report and review of literature].
Zhonghua er ke za zhi = Chinese journal of pediatricsWorld Health Organization-defined eosinophilic disorders: 2017 update on diagnosis, risk stratification, and management.
American journal of hematologyIdiopathic hypereosinophilic syndrome with 20 years of diagnostic delay.
Revista brasileira de hematologia e hemoterapiaTherapeutic effect of anti-IL-5 on eosinophilic myocarditis with large pericardial effusion.
BMJ case reportsWhen a death apparently associated to sexual assault is instead a natural death due to idiopathic hypereosinophilic syndrome: The importance of gamma-hydroxybutyric acid analysis in vitreous humor.
Legal medicine (Tokyo, Japan)Bone marrow morphology is a strong discriminator between chronic eosinophilic leukemia, not otherwise specified and reactive idiopathic hypereosinophilic syndrome.
HaematologicaIdiopathic hypereosinophilic syndrome manifesting with eosinophilic cholecystitis and recurrent gastroenteritis.
Annals of hematologyTotal artificial heart implantation for biventricular failure due to eosinophilic myocarditis.
Journal of artificial organs : the official journal of the Japanese Society for Artificial OrgansHypereosinophilic Syndrome After Liver Transplantation: A Case Report and a Review of the Literature.
TransplantationRapid Change in Mental Status in a Patient with Hypereosinophilia.
Case reports in hematologyANCA-Negative Churg-Strauss Syndrome Presenting as Acute Multiple Cerebral Infarcts: A Case Report.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke AssociationIdiopathic hypereosinophilic syndrome resulting in distal aortic thromboembolism in a dog.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)Idiopathic hypereosinophilic syndrome presenting with severe vasculitis successfully treated with imatinib.
World journal of clinical cases[Clinical characteristics and long- term therapeutic effects of 60 patients with idiopathic hypereosinophilic syndrome in a single center].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhiHypereosinophilic Syndrome: Hacettepe Experience.
Journal of pediatric hematology/oncologyIdiopathic hypereosinophilic syndrome presenting as angina pectoris: A case report.
International journal of cardiologyThe significance of early screening with echocardiography in eosinophilic granulomatosis with polyangiitis.
Journal of medical ultrasonics (2001)Idiopathic hypereosinophilic syndrome presenting with hepatitis and achalasia.
Clinical journal of gastroenterologyEosinophilic pleural effusion as a manifestation of idiopathic hypereosinophilic syndrome.
Archivos de bronconeumologiaTargeted next-generation sequencing identifies a subset of idiopathic hypereosinophilic syndrome with features similar to chronic eosinophilic leukemia, not otherwise specified.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, IncAn Unusual Case of Loffler Endomyocarditis after Takotsubo Cardiomyopathy Induced by Deep Neck Infection.
Acta Cardiologica SinicaCardiopulmonary and Gastrointestinal Manifestations of Eosinophil- associated Diseases and Idiopathic Hypereosinophilic Syndromes: Multimodality Imaging Approach.
Radiographics : a review publication of the Radiological Society of North America, IncA Case of Idiopathic Hypereosinophilic Syndrome Causing Mitral Valve Papillary Muscle Rupture.
Case reports in pediatricsWhole-exome sequencing and genome-wide methylation analyses identify novel disease associated mutations and methylation patterns in idiopathic hypereosinophilic syndrome.
OncotargetEndobronchial Involvement in Idiopathic Hypereosinophilic Syndrome.
Journal of bronchology & interventional pulmonologyWorld Health Organization-defined eosinophilic disorders: 2015 update on diagnosis, risk stratification, and management.
American journal of hematologyComparison of two leukocytapheresis protocols in a case of idiopathic hypereosinophilic syndrome.
Journal of clinical apheresisA Rare Case of Aortic Valve Thrombosis in Patient with Idiopathic Hypereosinophilic Syndrome.
Case reports in cardiologyTyrosine Kinase Inhibitors and Therapeutic Antibodies in Advanced Eosinophilic Disorders and Systemic Mastocytosis.
Current hematologic malignancy reportsReversible Severe Eosinophilic Endomyocardial Fibrosis During Pregnancy: A Case Report.
MedicineHypereosinophilic syndrome: an indolent rash with a serious cardiac complication.
Clinical and experimental dermatologyManagement of Hypereosinophilic Syndromes.
Immunology and allergy clinics of North AmericaAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
Ainda não temos associações cadastradas para Síndrome hipereosinofílico idiopático.
É de uma associação que acompanha esta doença? Fale com a gente →
Comunidades
Grupos ativos de quem convive com esta doença aqui no Raras
Ainda não existe comunidade no Raras para Síndrome hipereosinofílico idiopático
Pacientes, familiares e cuidadores se organizam em comunidades pra compartilhar experiências, fazer perguntas e se apoiar. Você pode ser o primeiro.
Tire suas dúvidas
Perguntas, dicas e experiências compartilhadas aqui na página
Participe da discussão
Faça login para postar dúvidas, compartilhar experiências e interagir com especialistas.
Fazer loginDoenças relacionadas
Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico
Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Idiopathic Hypereosinophilic Syndrome Presenting as Acute Encephalopathy Secondary to Watershed Ischemic Stroke.
- Idiopathic Hypereosinophilic Syndrome in a Child- Rare Disease with Fulminant Clinical Course.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion· 2026· PMID 41728149mais citado
- Laboratory Aspects and Diagnostic Challenges in a Case of Hypereosinophilic Syndrome.
- Real-world outcomes after anti-IL-5/anti-IL-5Rα treatment for hypereosinophilic syndrome: Systematic literature review.
- Clinical Utility of 18 F-FDG PET/CT in Patients With Hypereosinophilia : An 11-year Single-center Experience.
- Coronary vasospasm in a patient with RUNX1 mutation in eosinophilic leukemia and hypereosinophilic syndrome: A case report.
- Idiopathic Hypereosinophilic Syndrome in a Patient with End-Stage Renal Disease.
- Aortic Valve Annular Parameters in Idiopathic Hypereosinophilic Syndrome-A Detailed Investigation from the Three-Dimensional Speckle-Tracking Echocardiographic MAGYAR-Path Study.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:3260(Orphanet)
- OMIM OMIM:607685(OMIM)
- MONDO:0011895(MONDO)
- GARD:16625(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
