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Tetanus Severity Score for Prediction of Mortality in Manifest Tetanus

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Concurrent Versus Sequential Administration of Tdap and RSV Vaccines in Pregnancy

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Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective

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Clinical Trial of the Adsorbed Acellular Pertussis (Tricomponent) DTaP-Haemophilus Influenzae Type b (Conjugate)-ACYW135 Group Meningococcal (Conjugate) Combined Vaccine

NCT07203755

NCT07512167 · Tetanus Severity Score for Prediction of Mortality in Manife…Recrutando

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NCT07097012 · Concurrent Versus Sequential Administration of Tdap and RSV …Recrutando

PHASE4

NCT07358910 · Risk Assessment of Community Spread of Multiple Endemic Infe…Recrutando

NCT07107932 · A Registry： Siltartoxatug Injection for Tetanus Prophylaxis …Recrutando

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NCT07149454 · Clinical Trial to Evaluate the Safety, Tolerability, Pharmac…Por convite

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401 ensaios clínicos encontrados, 23 ativos.

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Publicações mais relevantes

Timeline de publicações

5.510 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 5.510

#1

Caregiver and healthcare professional perspectives on drivers of routine immunisation uptake in East New Britain, Papua New Guinea: a qualitative study.

BMJ public health2026

Immunisation coverage varies across Papua New Guinea (PNG), with 40% of children in East New Britain Province (ENBP) classified as zero-dose (children missing diphtheria-tetanus-pertussis vaccine first dose (DTP1)) and 55% as under-immunised (missing DTP3) in 2023. This study aimed to understand routine childhood immunisation enablers and barriers in areas of ENBP reported to have highly variable DTP1, DTP3 and measles-rubella first-dose (MR1) coverage. Qualitative in-depth semi-structured interviews were conducted face-to-face with caregivers of children aged 9-23 months and healthcare professionals in Gazelle and Kokopo districts. Local research officers conducted interviews in Tok Pisin and English. Data were thematically analysed and mapped across the six UNICEF Journey to Health and Immunisation framework stages. 33 caregivers and 28 healthcare professionals were interviewed. Despite finding that a high proportion of caregivers' children had received DTP, DTP3 and MR1, participants identified a myriad of contextual caregiver and healthcare professional enablers and barriers to routine immunisation. Caregiver enablers included support provided by families and community-based services; barriers included limited immunisation knowledge, financial and travel challenges, and limited availability of healthcare professionals. Healthcare professional enablers included increased operational funds and working with community leaders, while barriers were focused on service delivery including costs, non-functioning aid posts and vaccine stockouts. Strategies suggested by participants for improving vaccine uptake included developing tailored immunisation communication materials, engaging community members to support routine immunisation promotion activities, and strengthening coordination between communities and healthcare professionals. This study highlights the challenge of identifying and including zero-dose children and their caregivers in research but still provides useful contextual focus points to enhance and inform tailored strategies to strengthen immunisation service delivery. These include strategies that improve bidirectional coordination and communication between healthcare professionals, community and religious leaders about routine immunisation, increase immunisation knowledge and strengthen community-based services for vaccine delivery.

#2

Diphtheria and pertussis outbreaks in the Americas: a scoping review of epidemiology, vaccination trends and control strategies, 2013-2024.

BMJ public health2026

To describe the themes identified in the epidemiology of diphtheria and pertussis outbreaks in the Americas (2013-2024), with a particular focus on vaccination coverage, trends and control strategies. Scoping review. Systematic searches were conducted in PubMed and Embase (2024), supplemented by a search of Latin American and Caribbean Health Sciences Literature (LILACS) in December 2025. Regional case data and vaccination coverage were sourced from the Pan American Health Organization (PAHO)/WHO and UNICEF electronic joint reporting form (eJRF). The study reviewed literature and health reports focusing on diphtheria and pertussis outbreaks and vaccination coverage. Thematic analysis identified themes in the literature on the epidemiology and control strategies of diphtheria and pertussis as well as outbreak reporting and mortality. The retrospective regional data analysis encompassed aggregated eJRF data (2013-2024) on cases and on diphtheria-pertussis-containing vaccination coverage. Of 82 articles identified across 14 countries, 28 met the inclusion criteria. Diphtheria cases peaked in 2017-2018 and have been on an upward trend since. Pertussis cases surged to 66 184 in 2024, with 10 countries reporting high numbers and 17 having their third dose of the vaccine against diphtheria, tetanus and pertussis (DTP3) coverage below 90%. Outbreaks are often linked to low DTP3, inconsistent vaccination coverage, gaps in maternal and booster doses, inadequate surveillance and socioeconomic disparities. However, two countries with high DTP3 coverage (eg, the USA, Canada) still experienced pertussis outbreaks, showing the disease's complexity. Experts recommend scaling up vaccination and strengthening surveillance to address these challenges. Diphtheria and pertussis are resurging in the Americas. The growing number of 'zero-dose' children and socioeconomic disparities in vulnerable communities are exacerbating the problem. A comprehensive approach is recommended, prioritising increased vaccination efforts, strengthened surveillance and ensuring equitable access to healthcare services.

#3

Global patterns and disparities in maternal and child health: a panel analysis of global health observatory and world development indicators data, 2000-2023.

BMJ open2026 Mar 23

This study aims to evaluate global trends in maternal and child health-related indicators in the Millennium Development Goals (MDG) and Sustainable Development Goal (SDG) eras, examine whether these associations differ across regions and income groups and assess their impact on life expectancy (LE) at birth. We conducted a country-level panel analysis using data from 2000 to 2023 obtained from the Global Health Observatory and the World Development Indicator database. All WHO Member States with available data were included. Data on under-five mortality rate (U5MR), maternal mortality ratio (MMR), neonatal mortality rate (NMR), skilled birth attendance, ratio of nurses and midwives, total fertility rate (TFR), LE, prevalence of anaemia and hypertension in women aged 15-49 years, diphtheria tetanus toxoid and pertussis (DTP3) vaccine coverage, gross domestic product and government health expenditure as a percentage of GDP were collected, cleaned and prepared for analysis. Missing values (<10%) were imputed using linear interpolation and 5-year mean methods. Descriptive statistics and panel regression analyses were conducted to examine associations between maternal and child health indicators and LE. In addition, Joinpoint regression models were applied to assess temporal trends and estimate annual percent changes (APCs) during the MDG and SDG eras. All statistical analyses were performed using Stata MP version 17.0. Sensitivity analyses were conducted to evaluate the robustness of the findings. Trends in LE and maternal and child health indicators and maternal and child-related factors associated with LE. Maternal and child health improved substantially, with faster progress during the MDG era (2000-2015) compared with the SDG era (2015-2023). The MMR declined by 130.30 (100 in MDG vs 30.30 in SDG) deaths per 100 000 live births overall, from 327.60 (95% UI: 308.80-348.60) in 2000 to 197.30 (95% UI: 174.50-234.00) in 2023. Similarly, U5MR declined by 39.95 (28 in the MDG vs 11.95 in the SDG era) deaths, from 76.67 (95% UI: 75.70-77.86) to 36.72 (95% UI: 34.66-41.09) deaths per 1000 live births. The NMR decreased by 13.38 per 1000 live births, from 30.71 (95% UI: 29.91-31.58) to 17.33 (95% UI: 16.25-19.41) deaths, and LE increased by 6.6 years, from 66.77 (95% UI: 66.23-67.18) to 73.33 (95% UI: 72.73-73.93) globally. Fixed-effects regression results showed that higher U5MR (β=-0.0697, 95% CI -0.080 to -0.060, p<0.001), MMR (β=-0.0118, 95% CI -0.020 to -0.010, p<0.001), TFR (β=-0.0258, 95% CI -0.040 to -0.020, p<0.001) and prevalence of anaemia (β=-0.0223, 95% CI -0.030 to -0.010, p<0.001) were associated with reduced LE, whereas skilled birth attendance (β=0.0417, 95% CI 0.030 to 0.050, p<0.001), DPT3 coverage (β=0.0425, 95% CI 0.030 to 0.050, p<0.001) and GDP (β=0.0041, 95% CI 0.001 to 0.010, p=0.01) were associated with increased LE. Despite progress in maternal and child health, gaps remain, particularly in low-income and lower-middle-income countries. Strengthening and retaining the health workforce, expanding access to immunisation and family planning services and improving early detection and management of hypertension and anaemia among women are critical to sustaining gains and accelerating improvements in LE.

#4

Understanding adverse events following immunisation: evidence of vaccine safety and coincidental events from 3 years of surveillance.

BMJ paediatrics open2026 Mar 23

Periodic vaccine safety checks are a crucial component of any country's pharmacovigilance system. Unwanted reactions following childhood vaccination are unacceptable to the public, making rapid safety checks and alerts essential for maintaining public confidence. The study evaluates the safety of childhood vaccines in the paediatric population through active surveillance and explores various predictors for the development of adverse event following immunisation (AEFI) based on population characteristics. A cohort event monitoring study was designed to identify AEFIs in children receiving at least one childhood vaccine under the Universal Immunisation Programme (UIP) at the study site. Both active surveillance (via telephone follow-up calls) and passive surveillance (from healthcare workers) were included. Potential predictors of AEFIs were evaluated using the χ2 test, and relative risk was calculated. The study estimated an AEFI incidence rate of 10.37%, with 3.47% (1.27 events/1000 doses) being serious reactions requiring hospitalisation. The highest incidence was with the Pentavac vaccine (diphtheria, tetanus, pertussis, hepatitis B, Hib) at 19.21% (218 events/1000 doses), while the lowest incidence was observed with the oral polio vaccine at 0.13% (1.32 events/1000 doses). Most reported Adevrse Events were solicited (34.83 events/1000 doses), while unsolicited events accounted for 1.69/1000 doses. The most common reaction was fever (23.75 events/1000 doses), followed by pain at injection site (4.98 events/1000 doses). One death following Pentavac vaccination was reported but later deemed coincidental. Overall, 90.62% of the reactions were vaccine product-related, 4.76% coincidental, 2.70% immunisation error-related and 0.39% were indeterminate. Predictors of AEFIs included paediatric population, delayed immunisation, nutritional deficiencies and comorbid status of the child and children from affluent families. Childhood vaccines included in the UIP have shown a favourable safety profile. Serious reactions are infrequent, emphasising the need for thorough investigation and clear communication to differentiate them from coincidental reactions, which can occur more frequently in this age group.

#5

Optimising DTwP-containing vaccine infant immunisation schedules in Uganda and Nepal (OptImms): two open-label, non-inferiority, randomised controlled trials.

The Lancet. Infectious diseases2026 Mar 19

Few data are available comparing the WHO diphtheria-tetanus-pertussis (DTP)-containing vaccine schedule with reduced-dose or delayed three-dose schedules in infants. We aimed to identify an alternative schedule that is non-inferior or superior to the WHO schedule in maintaining early pertussis antibody levels before booster, while creating space for integration of new vaccines. In two parallel, open-label, randomised, non-inferiority trials in Uganda and Nepal, healthy infants aged 42-50 days were randomised in a 4:4:4:3:3 ratio via an online system to five diphtheria-tetanus-whole-cell pertussis-Haemophilus influenzae type b-hepatitis B (DTwP-Hib-HepB) vaccination schedules (WHO schedule [ages 6, 10, and 14 weeks]; reduced two-dose schedules at ages 6 and 14 weeks or ages 2 and 4 months; or delayed three-dose schedules at ages 2, 3, and 4 months or ages 2, 4, and 6 months), using site-stratified block randomisation with a block size of 18. The primary outcome was the pre-booster IgG antibody response against pertussis antigens (pertussis toxin; filamentous haemagglutinin [FHA]; pertactin; fimbriae 2 and 3 [Fim 2 and 3]). Antibody responses during and 1 month after the primary series were assessed as secondary endpoints. The two-dose schedules were compared with the WHO schedule as primary analyses, and the exploratory analyses were to compare delayed three-dose schedules with the WHO schedule. All these analyses were conducted in the per-protocol population. For the primary endpoint, non-inferiority margins for geometric mean ratios (GMRs) between two-dose and WHO schedules were calculated for each pertussis antigen separately as 35% of the standard deviation of the geometric mean concentrations of the WHO group, and non-inferiority was concluded if the lower bound of the 95% CI of the GMR exceeded the non-inferiority margin. A non-inferiority margin of 0·67 was used for all other non-inferiority comparisons. The trials were registered with ISRCTN (Uganda [ISRCTN60356654] and Nepal [ISRCTN12240140]) and are complete. Between Oct 1, 2021, and July 12, 2022 (Uganda) and Dec 5, 2021, and Feb 26, 2023 (Nepal), 956 infants were recruited per country and randomly allocated across the five study groups; pre-booster analyses were conducted in 876 participants in Uganda and 851 participants in Nepal. Two-dose schedules at ages 6 and 14 weeks and ages 2 and 4 months did not meet non-inferiority criteria for pertussis antibodies pre-booster, except FHA (non-inferiority margin 0·59) in Nepal (6 and 14 weeks GMR 0·83 [95% CI 0·61-1·13]; 2 and 4 months 1·20 [0·88-1·64]). Delayed three-dose schedules at ages 2, 3, and 4 months and ages 2, 4, and 6 months produced similar or higher post-primary series and pre-booster responses compared with the WHO schedule, but the WHO schedule achieved higher antibody responses against all pertussis antigens, except FHA in Nepal, at age 3 months. The WHO DTP schedule is the preferred schedule in high-pertussis-burden settings, as it elicits the greatest antibody responses in the first 3 months of life when infants are particularly vulnerable. Although delayed three-dose schedules may be considered in low-risk contexts and in settings with maternal immunisation programmes, early infant protection should guide policy decisions. Gates Foundation.

Publicações recentes

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Hotspot-based integrated serosurveillance of neglected tropical diseases, malaria, and vaccine-preventable diseases in urban Guyana.

Rev Panam Salud Publica2026

Tetanus Surveillance - United States, 2009-2023.

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Long-term trends in childhood mortality following the expansion of vaccination programs: a 60-year analysis from a university hospital in Rio de Janeiro State, Brazil.

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Ver todas no PubMed

📚 EuropePMC13.441 artigos no totalmostrando 197

Caregiver and healthcare professional perspectives on drivers of routine immunisation uptake in East New Britain, Papua New Guinea: a qualitative study.

BMJ public health

Diphtheria and pertussis outbreaks in the Americas: a scoping review of epidemiology, vaccination trends and control strategies, 2013-2024.

BMJ public health

Global patterns and disparities in maternal and child health: a panel analysis of global health observatory and world development indicators data, 2000-2023.

BMJ open

JAAPA : official journal of the American Academy of Physician Assistants

Addressing the crises of declining vaccination rates and measles resurgence by promoting health literacy.

Understanding adverse events following immunisation: evidence of vaccine safety and coincidental events from 3 years of surveillance.

BMJ paediatrics open

The Lancet. Infectious diseases

Optimising DTwP-containing vaccine infant immunisation schedules in Uganda and Nepal (OptImms): two open-label, non-inferiority, randomised controlled trials.

International journal of clinical pharmacy

Global burden shift from infectious to non-communicable neurological disorders in adolescents and young adults (10-24 years): findings from the global burden of disease study 1990-2021.

Prevalence, spatial patterns and determinants of zero-dose vaccination among children aged 12-23 months in Sub-Saharan Africa: A multilevel spatial analysis.

Intrauterine Aluminium Exposure Due to Dietary Content Alters Social Behaviours in Wistar Rat Offsprings.

Annals of neurosciences

Critical care (London, England)

10 years trends and hospitalization outcomes of non-neonatal tetanus: a large-scale multicenter retrospective study in China.

Seroprevalence of diphtheria, tetanus, pertussis among healthcare workers (HCWs) - A cross-sectional study at the National Centre for Infectious Diseases and Tan Tock Seng Hospital, Singapore.

Development and validation of immunological assays for preclinical evaluation of a novel bivalent typhoid conjugate vaccine.

Environmental epidemiology (Philadelphia, Pa.)

Associations of mid-childhood per- and polyfluoroalkyl substances and early childhood metals with mid-childhood antibody titers.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Severe rhabdomyolysis and refractory dysautonomia complicating generalized tetanus in an unvaccinated child: A case report.

Residential differentials in prevalence and factors associated with tetanus toxoid uptake among women of reproductive age in Nigeria: a Multiple Indicator Cluster Survey analysis (MICS 2021).

Allergy and asthma proceedings

Vaccinating patients on biologics for atopic disease: Clinical considerations and evidence-based recommendations.

Costs of managing adverse reactions to hexavalent vaccines: Comparison of DT3aP-HBV-IPV/Hib and DT2aP-HBV-IPV-Hib in France and Spain.

Adherence to Recommended Immunisation Schedules for Patients With Inflammatory Bowel Disease (IBD) on Biologics: A Retrospective Study at Our Lady's Hospital, Navan, Ireland.

The journal of allergy and clinical immunology. In practice

Recommended Vaccines for Immunocompetent Older Adults: Work Group Report of the AAAAI Allergy and Asthma in Older Adults Committee.

Perturbation-induced responses improved seizure forecasting in epileptic rats.

Epilepsia

Effectiveness of the influenza and Tdap vaccination educational module (InTroDuce-Programme) on knowledge and intention for antenatal vaccination: A cluster randomised controlled trial protocol among pregnant women in Malaysian primary care clinics.

European journal of epidemiology

Pregnancy exposure to individual phthalate concentrations and their mixtures in relation to pediatric serum antibody response.

European journal of pediatrics

Evaluation of vaccine immunity against tetanus, hepatitis B, measles, mumps, rubella and varicella, in migrant adolescents aged 13 to 18 years arriving in Geneva in 2023.

Journal of family medicine and primary care

A study on knowledge, attitude and practices (KAP) towards adult immunizations among health care professionals.

Evaluation of IVIG for Prevention of Infections Occurring On-study and Treatment of Infection of Solid Organ Recipients With Secondary Antibody Deficiency: A Phase 2 Randomized Clinical Trial.

Transplantation direct

Veterinary journal (London, England : 1997)

Clinical observations of tetanus toxin plus decoy, Snoretox-1, a novel targeted neuromuscular stimulant, in a pilot study of 6 British bulldogs with BOAS.

Research in veterinary science

Horse immune response of recombinant Lawsonia intracellularis vaccine: Assessing the immunomodulatory impact of probiotic supplementation.

Meningococcal quadrivalent ACYW-TT conjugated vaccine at 6-23 months: phase III study (US/Puerto Rico).

Pediatric research

A flexible antenna immunosensor with AuPt-graphene film for wireless detection of tetanus toxin.

Analytica chimica acta

Associations of serum PFAS with COVID-19 antibody levels among fully vaccinated adults.

Environmental research

Uncommon intraoral source of generalized tetanus: Case report and review of intensive care strategies.

IDCases

JNMA; journal of the Nepal Medical Association

Open Clavicle Fracture: A Case Report.

Mortality and Associated Factors Among Adult Tetanus Patients Admitted at Public Hospitals in Bahir Dar City, Ethiopia: A Cross-Sectional Study.

Health science reports

JNMA; journal of the Nepal Medical Association

Cricothyroidotomy for Can't Intubate, Can't Oxygenate Situation in Emergency Department.

Gastroenterologia y hepatologia

Vaccination recommendations and adherence in inflammatory bowel disease: A physician-patient discordance study.

Botulinum neurotoxins: A distinct subclass of SNARE-Cleaving endopeptidases.

Anaerobe

When Neurology Meets Art History: Tetanus (or Rabies) in a 19th-Century Painting (Neurology and Art).

European neurology

An Atypical Presentation of Guillain-Barré Syndrome: Bilateral Facial Nerve Palsy With Preserved Reflexes.

Factors associated with pertussis infection and suspected cases in the Aseer Region, Saudi Arabia: a retrospective cross-sectional analysis study.

International medical case reports journal

Generalized Tetanus in an Unvaccinated Adolescent: A Case Report on Successful Management in a Resource-Limited Setting.

Geographic disparities and determinants of DTP3 vaccination coverage among children aged 0-59 months in Somalia: a multilevel analysis.

Conflict and health

B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes.

Immunity

Mayo Clinic proceedings. Innovations, quality & outcomes

Antenatal Care and Perinatal Mortality in Low- and Middle-Income Countries: Insights for Maternal and Newborn Health System.

Medicina (Kaunas, Lithuania)

Tetanus Control in the United States and Global Disaster Settings: Public Health Disparities and Prevention Strategies.

Bayesian spatiotemporal modelling of neonatal, infant and under-5 mortality (2000-2022) in 41 Asian countries: a population-level observational study.

BMJ open

Evaluation of the MenACWY Vaccination Catch-Up Campaign Among Adolescents in Madrid: Coverage, Trends, and Determinants.

Timeliness of Routine Vaccination, Catch-Up Completion, and Immune Function in Chinese Children with Special Healthcare Needs: A Retrospective Cohort Study.

Safety and health-related quality of life following maternal respiratory syncytial virus (RSV) and diphtheria-tetanus-acellular pertussis (DTaP) vaccinations.

Seroepidemiological study of pertussis in Henan Province, China, and prediction of the effectiveness of a new immunization strategy.

Biosafety and health

Transplant infectious disease : an official journal of the Transplantation Society

Impact of CD19 CAR T-Cell Therapy on Pathogen-Specific Antibody Titers in Lymphoma Patients.

Communicable diseases intelligence (2018)

Annual Immunisation Coverage Report 2023.

bioRxiv : the preprint server for biology

Prefrontal-medullary circuitry is necessary for sex-specific responses to metabolic stress in rats.

Chinese journal of traumatology = Zhonghua chuang shang za zhi

Global burden, trends, and projections of tetanus for 2050: Based on the 2021 Global Burden of Disease Study.

Trends and recovery of routine childhood immunization before, during, and after the COVID-19 pandemic in Ethiopia: A five-year trend analysis.

Biosensors & bioelectronics

Gold/vertical-graphene-based dual-channel electrochemical immunosensor for point-of-care testing of tetanus toxin in blood.

A Potential Case of Tetanus-Diphtheria Vaccine-Induced Immune Thrombocytopenia.

Frontiers in cellular and infection microbiology

Diphtheria-tetanus-acellular pertussis vaccine safety in children under 7 years: a post-marketing analysis of the U.S. vaccine adverse event reporting system.

Tetanus infection in an 11-year-old male with full infant vaccination history: a rare case report.

BMC pediatrics

Association of parental vaccination readiness and descriptive norms with childhood vaccination status.

An observational, cohort, multi-centre, open label phase IV extension study comparing IPV immune responses to preschool dTaP-IPV booster vaccines in children whose mothers received or did not receive an IPV-containing pertussis vaccine during pregnancy in England.

Economic evaluation of national immunization program vaccines in China: a systematic review.

Health economics review

Generation of a SV2A knockout human embryonic stem cell line by CRISPR/Cas9 system.

Stem cell research

Frontiers in cellular and infection microbiology

Risk signal assessment of Tdap vaccine use alone by pregnant women: An updated pharmacoepidemiological study.

Zhonghua er ke za zhi = Chinese journal of pediatrics

[Clinical characteristics and outcomes of pertussis encephalopathy in 17 children].

PLOS global public health

Timeliness of vaccine administration among children in urban informal settlements in Nairobi, Kenya.

Journal of orthopaedic case reports

The Clean Pass: Upper Limb Impalement with Complete Neurovascular Preservation.

The American journal of tropical medicine and hygiene

Intrathecal Human Tetanus Immunoglobulin for Post-Neonatal Tetanus in Resource-Limited Settings: An Old Idea with New Evidence.

The American journal of tropical medicine and hygiene

Effectiveness of Intrathecal Tetanus Immunoglobulin in Postneonatal Tetanus: A Retrospective Comparative Study (TIG-TET Study).

Journal of Korean medical science

Pertussis Outbreak Investigation in a Korean Middle School: Insights on Tdap and Td Vaccination.

Clinical and experimental vaccine research

Knowledge, attitudes and practices towards immunization among adult population in a tertiary care hospital-exploratory survey.

Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit

Ten-year analysis of the epidemiologic characteristics of whooping cough in Kyrgyzstan.

Factors associated with tetanus, diphtheria and pertussis (Tdap) vaccination acceptance among pregnant women: a cross-sectional study.

BMC infectious diseases

Disparities and barriers to life-course vaccination in Ethiopia: Evidence from a household survey.

Journal of the neurological sciences

Opisthotonus: Revisiting a classic movement disorder.

JMIR pediatrics and parenting

Modeling Zero-Dose Children in Ethiopia: A Machine Learning Perspective on Model Performance and Predictor Variables.

Preliminary safety evaluation of a diphtheria, tetanus, acellular component pertussis, Sabin inactivated poliovirus and Haemophilus influenzae type b combination vaccine (DTacP-sIPV/Hib).

Emerging microbes & infections

Safety and immunogenicity of diphtheria, tetanus and pertussis (acellular, three components) combined vaccine, adsorbed after three-dose priming in 2 months age infants: a randomized, blinded, controlled phase III clinical trial in China.

A Glycopeptide Mosaic Vaccine Elicits Robust Antitumor Immunity by Targeting Glycan Heterogeneity.

JACS Au

Penetrating Foot Injury Caused by a Retained Wood Screw: A Case Report.

Insights into vaccination: a cross-sectional study of knowledge, attitudes, and barriers among community pharmacists in Türkiye.

Public health nursing (Boston, Mass.)

Enhancing Adolescent Vaccine Acceptance: A Multi-Component Intervention Study on 13-Year-Old Tetanus-Diphtheria Vaccination.

Portal vein thrombosis as a clinical dilemma in Echis carinatus envenomation: a case report and review of the literature.

Thrombosis journal

Co-administration of recombinant zoster vaccine with other recommended vaccines among older adults in the United States of America.

Preventive medicine

Infectious diseases and therapy

Immunogenicity and Safety of Quadrivalent Meningococcal Conjugate Vaccine (MenACYW-TT) in Potential Hajj/Umrah Pilgrims Aged ≥ 56 Years: A Phase III, Open-Label Study.

Liver Safety Assessment of an Indonesian Hexavalent Vaccine Candidate Through Histopathology and ALT/AST Evaluation in Rats and Rabbits.

Alternative Childhood Vaccination Schedules in Israel: A Mixed-Methods Study on Prevalence, Patterns, and Public Health Implications.

Trends in Women's Empowerment and Their Association with Childhood Vaccination in Cambodia: Evidence from Demographic and Health Surveys (2010-2022).

Preclinical Study on Sabin Strain-Based DTaP-sIPV/Hib Pentavalent Vaccine: Evaluation of Repeated-Dose Toxicity and Immunogenicity.

Complete Neutralization of Tetanus Neurotoxin by Alpaca-Derived Trivalent Nanobodies Aimed at Veterinary Medical Applications.

Veterinary sciences

Severe Generalized Tetanus in a Chimpanzee (Pan troglodytes) Under Human Care: A Case Report from the Republic of Congo.

Veterinary sciences

The Journal of infectious diseases

The effect of pertussis vaccination during pregnancy on the binding epitopes and avidity of anti-pertussis toxin IgG antibodies in infants and their mothers.

Infant Immunity after Maternal Nipocalimab in Severe Hemolytic Disease of the Fetus and Newborn.

NEJM evidence

Tropical medicine and infectious disease

Finding the Gaps: Integrated Serosurveillance and Spatial Clustering of Vaccine Preventable Diseases in Samoa, 2018-2019.

Advances in Clostridial Neurotoxins: Passage of the Intestinal Barrier and Targeting of Specific Neuronal Cells.

Toxins

The Lancet. Infectious diseases

Safety and immunogenicity of a conjugate vaccine candidate against Salmonella enterica serovars Typhi and Paratyphi A in healthy adults in Europe: a phase 1 randomised controlled trial.

Descriptive epidemiology of animal-induced injuries in Sandun Town, Hangzhou, China.

Responses to Tetanus and Meningococcal Vaccines in Patients with Alopecia Areata Treated with Ritlecitinib.

Dermatology and therapy

Journal of the American Medical Directors Association

The Prevalence and Impact of Vaccination Programs: Differences Between Nursing Homes and Assisted Living Communities.

PLOS global public health

The role of the media in the coverage of childhood vaccination in children under two years of age in Peru, ENDES 2021-2024.

Health care analysis : HCA : journal of health philosophy and policy

From School-Based Immunization to Family Health Centers: the Impact of a 2020 Policy Change on 13-Year-Old Tetanus-Diphtheria Vaccine Coverage in Turkey.

Annals of African medicine

Coral Fragment Injury Simulating a Sea Urchin Sting: A Rare Case Report from Mauritius in a Tourist.

[Hidden danger: a tare cause of painful muscle spasms after long-lie].

Praxis

Preventive medicine reports

Vaccine delay in routine childhood vaccines in the post-COVID-19 era in Jiangning, Nanjing, China.

Pyramidal neurons proportionately alter cortical interneuron subtypes.

Nature

Impact of a community-led intervention on the uptake of childhood vaccines in Liverpool: a protocol for a synthetic control evaluation.

BMJ open

Emergency response and clinical treatment analysis of a mass wasp sting incident involving 38 tourists: A case report.

Medicine

The impact of social vulnerability on primary vaccine coverage in children with sickle cell disease.

Assessment of health technician students' awareness of dental trauma in Turkey.

BMC medical education

Safety, immunogenicity, and lot consistency of a 13-valent pneumococcal conjugate vaccine in Chinese children aged 2-5 years: A phase III study.

Angewandte Chemie (International ed. in English)

Chemoenzymatic Synthesis of Glycopeptide Library Decodes Sialylation-Dependent Immunodominance to Enable a Potent Multicomponent Antitumor Vaccine.

A rare case of non-wound tetanus mimicking botulism successfully managed in the ICU.

IDCases

Low maternal pertussis protection and quantified infant risk: supporting maternal Tdap vaccination in China.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

Vaccine acceptance in gravid patients in the COVID-19 era.

Archives of gynecology and obstetrics

Improved pertussis vaccine uptake following in-hospital administration among pregnant women living with HIV.

Tetanus in a developing nation: a rare disease in the vaccination era?

BMJ case reports

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Seroprevalence of antibodies against diphtheria, tetanus, and pertussis over a 12-year period in children in Kilifi, Kenya (2009-2021).

Immunological responses to tetanus, diphtheria, pertussis (Tdap) vaccine in Brazilian hematopoietic stem cell transplant recipients.

Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil

Use of Bradford Hill causality criteria in cluster of events attributable to pentavalent vaccine: cohort and case-non-case studies, Brazil, 2020-2022.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

RSVPreF3OA vaccine responses in kidney transplant recipients and dialysis patients versus healthy controls.

Mucosal immune responses to Bordetella pertussis in Gambian infants after maternal and primary vaccination: an immunological substudy of a single-centre, randomised, controlled, double-blind, phase 4 trial.

The Lancet. Microbe

Evaluation of methods to increase the expression of cytokine-induced killer cell chemoattractant cytokines in pancreatic cancer.

Gene therapy

Tetanus Toxoid Vaccine Uptake and Associated Factors Among Reproductive Age Women in Mogadishu, Somalia: A Cross-Sectional Study.

IJID regions

Maternal Vaccine Receipt and Infant Hospital and Emergency Visits for Influenza and Pertussis.

JAMA network open

European journal of immunology

SARS-CoV-2 mRNA Vaccination Leads to Transient Humoral and B Cell Bystander Responses in Adults.

Microbiology and molecular biology reviews : MMBR

The many journeys of botulinum neurotoxins and the bacteria that produce them-evolutionary, geographic, and research-related movements that have contributed to our understanding of a diverse pathogen.

Exploration of factors influencing the insufficient rate of tetanus vaccination among young women in an urban health zone: A cross-sectional study.

Medicine

Social science & medicine (1982)

Social capital and uptake of primary healthcare during protracted displacement: Evidence from four refugee settlements in northern Uganda.

[Vaccination of Older Adults in Portugal: Recommendations from the Geriatrics Study Group of the Portuguese Society of Internal Medicine].

Acta medica portuguesa

Safety and immunogenicity of a 3-dose schedule of a quadrivalent meningococcal tetanus toxoid conjugate vaccine administered concomitantly with routine pediatric vaccines to infants and toddlers: A descriptive randomized study.

Prolonged impairment of immunological memory after anti-CD20 treatment in pediatric idiopathic nephrotic syndrome: an extended follow-up.

Pathogens (Basel, Switzerland)

Vaccinations for Expecting Mothers to Improve Pregnancy Care in Middle Tennessee.

BMC pregnancy and childbirth

Prevalence and risk factors of stillbirths among pregnant women from twelve high-volume birthing facilities of Karachi, Pakistan: a longitudinal cohort study.

Seroprevalence of diphtheria and tetanus antibodies among children and adolescents in high- and low-immunization coverage areas in the Lao People's Democratic Republic.

Assessing vaccination coverage and antibody levels for measles, pertussis, and tetanus in Boende, DR Congo: Implications for maternal and child health.

Revista panamericana de salud publica = Pan American journal of public health

[Risk factors associated with maternal and child pertussis vaccination coverage in MexicoFatores de risco associados à vacinação materno-infantil contra a pertússis no México].

The use of recommended vaccinations among patients with chronic diseases in relation to attitudes toward vaccination and anxiety levels.

BMC infectious diseases

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

[Expert consensus on the application of passive immune preparation for post-exposure prophylaxis against tetanus].

Large differences in MMR and DTaP-IPV vaccination coverage among primary schools by denomination, the Netherlands, 2024.

Pregnant Women and Vaccine Safety in Uganda: Knowledge, Barriers, and Opportunities for Engagement.

Systematic review of mHealth and digital health interventions to improve childhood vaccination uptake in 19 Sub-Saharan African countries.

Ensuring structural integrity of Hib capsular polysaccharide in conjugate vaccine manufacturing by 1H NMR and HPSEC-MALLS/RI.

A 15-year population-based study on incidence and vaccination coverage in pediatric inflammatory bowel disease in Italy.

Pediatric investigation

Impact of pregnancy on longitudinal pertussis antibody responses to Tdap vaccine in Guatemala.

Tropical medicine and health

Clinically diagnosed tetanus in a 58-year-old female with breast fungating mass.

A DC-Sensitive Video/Electrophysiology Monitoring Unit for Long-Term Continuous Study of Seizures and Seizure-Associated Spreading Depolarization in a Rat Model.

eNeuro

Evaluation of anti-tetanus IgG antibody levels and influencing factors in patients undergoing hemodialysis.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

Maternal and infant immunity against Bordetella pertussis, Norway, 2020 to 2023.

Comparison of characteristics and injury patterns between minor and adult patients seeking emergency cosmetic suture for facial lacerations: data from a tertiary plastic surgery hospital in Beijing, China.

Monitoring the SDG immunization indicator: Approaches and challenges.

[Modern approach in management of patients with lower third face lacerated wounds].

Stomatologiia

Revista colombiana de obstetricia y ginecologia

Expert consensus on vaccination as a primary prevention strategy for women of reproductive age, pregnant, or adulthood.

Medicine and science in sports and exercise

Time Required for the Restitution of Extra Initial Force in Fast Motor Units of the Rat Medial Gastrocnemius Muscle.

Tetanus toxoid immunization coverage and its determinants among pregnant women in Somalia: A cross-sectional analysis of the 2020 Demographic and Health Survey.

Annals of clinical epidemiology

Association of age-appropriate vaccination status at 24 months with all-cause hospitalizations: A retrospective cohort study.

Actas dermo-sifiliograficas

Panniculitis Associated With the Diphtheria-Tetanus-Pertussis Vaccine.

Joint diseases and related surgery

High-pressure injection injury with concrete to the hand and forearm.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

Coverage and determinants of maternal RSV vaccination in Japan: A nationwide survey.

Immunity to six vaccine pathogens in HIV positive and HIV negative children in Equatorial Guinea.

Scientific reports

Parental concerns, behaviours, and attitudes associated with childhood vaccinations in Albania: a cross-sectional study.

Italian journal of dermatology and venereology

Pityriasis rubra pilaris triggered by vaccination.

Determinants of quality antenatal care among adolescent girls and women in Sierra leone: insights from the 2019 demographic health survey.

Reproductive health

Decomposition of socioeconomic inequalities in zero-dose children aged 12-23 months in India.

Scientific reports

Accuracy of self-reported vaccination status using surveys in safety-net, integrated and rural health systems in Colorado.

Reporting profile of adverse events following DTaP-IPV/Hib pentavalent vaccine: A 13-year real-world surveillance data analysis.

Real-world utilization and potential clinical and economic value of recombinant zoster vaccine and select preventive services recommended for older adults in the United States.

Geospatial inequalities in zero-dose vaccination and structural determinants: Insights from sub-Saharan Africa (2015-2023).

Estimating diphtheria, acellular pertussis, tetanus vaccine (DTaP) effectiveness in preventing pertussis in children aged three months to six years old in Shenzhen area, China, case control study.

Social and health system factors associated with maternal mortality in Eastern and Western China: Population health estimates using provincial-level data.

PLoS medicine

Trends in childhood routine immunisation and maternal health service access and utilisation in Sokoto State, Nigeria. A quantitative survey.

Scientific reports

A Phase 3 study to assess the safety and immunogenicity of a quadrivalent meningococcal conjugate vaccine (MenACYW-TT) co-administered with routine pediatric vaccines in healthy infants in the USA and Puerto Rico.

Tracking the progress of maternal pertussis vaccination coverage among upper-middle- and high-income countries and territories - a systematic review and modeling study.

EClinicalMedicine

Frontiers in global women's health

Maternal and child health services during the COVID-19 pandemic in India: an interrupted time-series analysis.

Maternal vaccine delivery costs in South Asian settings: estimates from Bangladesh and Nepal.

Immunogenicity and safety of co-purified diphtheria, tetanus and acellular pertussis vaccine in 6-year-old Chinese children.

Nature communications

Profile and management of war casualties in the context of limited resources and conflict in the Eastern Democratic Republic of Congo: a retrospective observational study.

Global epidemiology of vaccine-associated intussusception in children and adolescents, 1968 to 2024: An international pharmacovigilance study.

Medicine

Pharmaceuticals (Basel, Switzerland)

Longitudinal Cohort Event Monitoring of MMR and DT-IPV Vaccination at 9 Years of Age in The Netherlands.

Molecules (Basel, Switzerland)

Simultaneous Quantification of Multiple Analytes in Rat Plasma by UHPLC-MS/MS Following Oral Administration of Gastrodiae Rhizoma Extract for Pharmacokinetic Evaluation.

Emerging microbes & infections

Effectiveness of DTaP-IPV//PRP-T vaccine against pertussis among infants and toddlers in Zhejiang, China: a retrospective cohort study.

ACS biomaterials science & engineering

Biophysical Insights into the Effects of Alkyl Glucoside Surfactant Structural Characteristics on Antigen Stability under Thermal and Mechanical Stress.

Comparison of IgG antibody levels, avidity, and subclass distribution against pertussis toxin in children and adolescents after four-dose primary whole-cell (DTwP) or acellular (DTaP) vaccination, each followed by a single DTaP booster.

Immunology letters

Variations in Routine Childhood Vaccination Gaps: A Decomposition Analysis Across 80 Low- and Middle-Income Countries.

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]

[Evaluation of the protective effect of acellular DPT vaccine for booster immunization in 6-year-old children].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]

[Investigation on awareness of the adjusted DTaP immunization schedule and its influencing factors among immunization service personnel in China in 2025].

Complement-independent pathogenic influences of anti-HMGCR + and anti-SRP + immune-mediated necrotizing myopathy autoantibodies on engineered muscle function.

Skeletal muscle

Pediatric rheumatology online journal

Vaccination coverage, immune responses, and clinical characteristics in children with PFAPA syndrome: a monocentric prospective study.

American journal of obstetrics and gynecology

Effectiveness of 5-pertussis-component tetanus, diphtheria, and acellular pertussis (Tdap5) vaccination in pregnancy at preventing infant pertussis.

Methods in molecular biology (Clifton, N.J.)

Synaptic Silencing with Transactivation of Tetanus Neurotoxin for Pathway-Selective Manipulation.

The Journal of physiology

Optimal neuromuscular performance requires motor neuron phosphagen kinases.

Improving uptake of pediatric vaccines through religious conferences and mobile vaccine clinics in Aceh, Indonesia (TABRIE): study protocol for a stepped wedge cluster randomized controlled trial.

Trials

Utilization of tetanus and diphtheria serology tests in Alberta, Canada: Patterns and implications.

Association between vaccinations and risk of dementia: a systematic review and meta-analysis.

Age and ageing

Journal of controlled release : official journal of the Controlled Release Society

Unveiling the potential of neuron-targeted dendriplexes for siRNA delivery using a PNS-CNS-on-Chip.

Emergency medicine clinics of North America

General Approach to Weakness.

Parental vaccine refusal, non-vaccinated children, and outbreaks of Vaccine-Preventable Diseases (VPDs) in Europe: a systematic review of aetiology and risk.

Tropical medicine and health

Diphtheria outbreak in Somalia: a weekly sitrep on the recent health crisis-2025.

Discovery of protease inhibitors from bacteria as novel adjuvants for oral vaccine formulations.

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