Infecção por Toxoplasma congênita.
Introdução
O que você precisa saber de cara
Infecção por Toxoplasma congênita.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Entender a doença
Do básico ao detalhe, leia no seu ritmo
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 5 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 26 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
Triagem neonatal (Teste do Pezinho)
A triagem neonatal permite diagnóstico precoce e início imediato do tratamento.
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Nenhum gene associado encontrado
Os dados genéticos desta condição ainda estão sendo catalogados.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Toxoplasmose congênita
Centros de Referência SUS
24 centros habilitados pelo SUS para Toxoplasmose congênita
Centros para Toxoplasmose congênita
Detalhes dos centros
Hospital Universitário Prof. Edgard Santos (HUPES)
R. Dr. Augusto Viana, s/n - Canela, Salvador - BA, 40110-060 · CNES 0003808
Serviço de Referência
Hospital Infantil Albert Sabin
R. Tertuliano Sales, 544 - Vila União, Fortaleza - CE, 60410-794 · CNES 2407876
Serviço de Referência
Hospital de Apoio de Brasília (HAB)
AENW 3 Lote A Setor Noroeste - Plano Piloto, Brasília - DF, 70684-831 · CNES 0010456
Serviço de Referência
Hospital Estadual Infantil e Maternidade Alzir Bernardino Alves (HIABA)
Av. Min. Salgado Filho, 918 - Soteco, Vila Velha - ES, 29106-010 · CNES 6631207
Serviço de Referência
Hospital das Clínicas da UFG
Rua 235 QD. 68 Lote Área, Nº 285, s/nº - Setor Leste Universitário, Goiânia - GO, 74605-050 · CNES 2338424
Serviço de Referência
Hospital Universitário da UFJF
R. Catulo Breviglieri, Bairro - s/n - Santa Catarina, Juiz de Fora - MG, 36036-110 · CNES 2297442
Atenção Especializada
Hospital das Clínicas da UFMG
Av. Prof. Alfredo Balena, 110 - Santa Efigênia, Belo Horizonte - MG, 30130-100 · CNES 2280167
Serviço de Referência
Hospital Universitário Julio Müller (HUJM)
R. Luis Philippe Pereira Leite, s/n - Alvorada, Cuiabá - MT, 78048-902 · CNES 2726092
Atenção Especializada
Hospital Universitário João de Barros Barreto
R. dos Mundurucus, 4487 - Guamá, Belém - PA, 66073-000 · CNES 2337878
Serviço de Referência
Hospital Universitário Lauro Wanderley (HULW)
R. Tabeliao Estanislau Eloy, 585 - Castelo Branco, João Pessoa - PB, 58050-585 · CNES 0002470
Atenção Especializada
Instituto de Medicina Integral Prof. Fernando Figueira (IMIP)
R. dos Coelhos, 300 - Boa Vista, Recife - PE, 50070-902 · CNES 0000647
Serviço de Referência
Hospital Pequeno Príncipe
R. Des. Motta, 1070 - Água Verde, Curitiba - PR, 80250-060 · CNES 3143805
Serviço de Referência
Hospital Universitário Regional de Maringá (HUM)
Av. Mandacaru, 1590 - Parque das Laranjeiras, Maringá - PR, 87083-240 · CNES 2216108
Atenção Especializada
Hospital de Clínicas da UFPR
R. Gen. Carneiro, 181 - Alto da Glória, Curitiba - PR, 80060-900 · CNES 2364980
Serviço de Referência
Hospital Universitário Pedro Ernesto (HUPE-UERJ)
Blvd. 28 de Setembro, 77 - Vila Isabel, Rio de Janeiro - RJ, 20551-030 · CNES 2280221
Serviço de Referência
Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira (IFF/Fiocruz)
Av. Rui Barbosa, 716 - Flamengo, Rio de Janeiro - RJ, 22250-020 · CNES 2269988
Serviço de Referência
Hospital São Lucas da PUCRS
Av. Ipiranga, 6690 - Jardim Botânico, Porto Alegre - RS, 90610-000 · CNES 2232928
Serviço de Referência
Hospital de Clínicas de Porto Alegre (HCPA)
Rua Ramiro Barcelos, 2350 Bloco A - Av. Protásio Alves, 211 - Bloco B e C - Santa Cecília, Porto Alegre - RS, 90035-903 · CNES 2237601
Serviço de Referência
Hospital Universitário da UFSC (HU-UFSC)
R. Profa. Maria Flora Pausewang - Trindade, Florianópolis - SC, 88036-800 · CNES 2560356
Serviço de Referência
Hospital das Clínicas da FMUSP
R. Dr. Ovídio Pires de Campos, 225 - Cerqueira César, São Paulo - SP, 05403-010 · CNES 2077485
Serviço de Referência
Hospital de Base de São José do Rio Preto
Av. Brg. Faria Lima, 5544 - Vila Sao Jose, São José do Rio Preto - SP, 15090-000 · CNES 2079798
Atenção Especializada
Hospital de Clínicas da UNICAMP
R. Vital Brasil, 251 - Cidade Universitária, Campinas - SP, 13083-888 · CNES 2748223
Serviço de Referência
Hospital de Clínicas de Ribeirão Preto (HCRP-USP)
R. Ten. Catão Roxo, 3900 - Vila Monte Alegre, Ribeirão Preto - SP, 14015-010 · CNES 2082187
Serviço de Referência
UNIFESP / Hospital São Paulo
R. Napoleão de Barros, 715 - Vila Clementino, São Paulo - SP, 04024-002 · CNES 2688689
Serviço de Referência
Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
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Publicações mais relevantes
Evaluating how demography and temperature increase might alter the burden of congenital Toxoplasmosis in Africa.
The impact of climate change on environmental pathogens is a question whose importance will amplify in coming years. The protozoan parasite and global zoonosis Toxoplasma gondii is one such: empirical evidence indicates that oocyst survival is reduced at high temperatures. Paradoxically, a decline in incidence of T. gondii infections could amplify the burden of this disease, as the most damaging outcome occurs subsequent to first infection during pregnancy, and reductions in the incidence of the infection will increase the average age of first infection. We blend models of infection dynamics rooted in occurrence across the African continent with models of human demography to bound expectations for the future burden of this pathogen, accounting for the effects of changing temperatures. We discuss targeting efforts and approaches for mitigation.
Seroprevalence and Genotype Distribution of Toxoplasma gondii Among Pregnant Women in Northwest Ethiopia: A Cross-Sectional Study.
Toxoplasma gondii (T. gondii) infection poses significant risks during pregnancy, yet data on seroprevalence and genotype diversity in Ethiopia are scarce. This study aimed to determine the seroprevalence, associated risk factors, and genotype distribution of T. gondii among pregnant women in Northwest Ethiopia. A cross-sectional study was conducted among 554 pregnant women attending antenatal care in public hospitals between January 2022 and April 2024. Systematic random sampling was used. ELISA detected T. gondii-specific IgG and IgM antibodies, and PCR-RFLP targeting B1 and SAG2 loci were used for genotyping. Overall seroprevalence was 54.3%, with 6.1% testing IgG-positive only, 9.4% IgM-positive only, and 38.8% positive for both. Cat ownership (AOR = 2.2; 95% CI: 1.4-3.5) and dog ownership (AOR = 4.9; 95% CI: 2.9-8.1) were significantly associated with infection. Among 28 IgM-positive samples, Type II strains predominated (50%), followed by Types I and III (25% each). These findings support targeted screening and pet-handling education to reduce the risk of congenital toxoplasmosis. Further molecular surveillance is recommended to inform public health strategies.
Using dried blood spots to estimate Toxoplasma gondii seroprevalence in pregnant women in Catalonia, Spain, and to serologically diagnose congenital toxoplasmosis.
Recent data on toxoplasmosis seroprevalence in Spain is limited, and pregnancy-screening programs are being discontinued. This study aimed to describe seroprevalence in pregnant women in Catalonia using newborn dried blood samples (DBS) from the Catalonian Newborn Screening (NBS) Program; as well as to assess detection of Toxoplasma gondii antibodies in DBS (Anti-Toxoplasma gondii ELISA (IgG/IgM), Euroimmun Lubeck, Germany) as a NBS tool and for retrospective diagnosis of congenital toxoplasmosis (CT) in cases from the Spanish Research Network of Congenital Toxoplasmosis (REIV-TOXO). A total of 3,231 DBS samples from NBS program (September 2022-August 2023) were randomly selected and analyzed, alongside with 30 DBS from CT confirmed cases. The overall seroprevalence of T. gondii IgG in pregnant women was 15.5% (95%CI: 14.33-16.85), higher in foreign women 22.6%, particularly Latin American (30.3%). Analysis of DBS from CT cases showed concordance in IgG detection but only 3.3% (1/30) were IgM positive despite 37% (10/27) having positive serum IgM at birth. In conclusion, IgG analysis in newborn DBS provides valuable information on pregnant seroprevalence. However, its value for identifying CT cases in retrospective diagnosis or as neonatal screening is poor given the low IgM detection. Thus, prenatal screening remains the most effective approach to identify children at risk.
A safe and efficacious inactivated vaccine aids prevent reproductive failure associated with congenital toxoplasmosis in ovine.
Toxoplasma gondii is an apicomplexan parasite causing reproductive failure in small ruminants. In this study, we evaluated the capacity of an inactivated vaccine to prevent reproductive failure caused by congenital toxoplasmosis in sheep. The vaccine is based on an antigen extract obtained from a low passage T. gondii Type III isolate (TgPigSp1) preserving the ability to spontaneously produce cysts in vitro and following a procedure involving parasite inactivation via hyperosmotic shock and membrane proteins solubilisation. The vaccine prototype, consisting of 40 µg of parasite extract adjuvanted with QuilA®, was evaluated in two different trials using a pregnant ovine model of T. gondii infection based on orally challenging sheep at 90 days of gestation with 10 sporulated oocysts of the heterologous Type II isolate TgShSp1. Two subcutaneous immunizations at days 55 and 76 of pregnancy caused mild and transient local reactions and had no discernible impact on gestation. Vaccination triggered both specific cellular and humoral immune responses. The proportion of viable gestations resulted in 100% (vaccine trial 1) and 78% (vaccine trial 2) in vaccinated/challenged ewes versus 50% in unvaccinated/challenged sheep. This increase in viable gestations was associated with a significant increase of lambs born viable for vaccine trial 1 (62.5%) and a decrease of early foetal losses (i.e. abortion) for vaccine trial 2 (70%), associated with control of T. gondii multiplication in the cotyledons. This inactivated vaccine could be a suitable and practical tool to mitigate economic losses in sheep caused by T. gondii outbreaks.
Comparative IgG-IgM Western Blot in the Diagnosis of Congenital Toxoplasmosis: A Valid Diagnostic Tool.
Congenital toxoplasmosis (CT) results from vertical transmission of Toxoplasma gondii during maternal infection in pregnancy. Early diagnosis in newborns is crucial to initiate timely therapy and prevent long-term sequelae. The IgM Immunosorbent Agglutination Assay (ISAGA) has historically been considered an important diagnostic tool for CT; however, its recent market withdrawal necessitates alternative approaches. We conducted a retrospective observational study at Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, including 44 newborns born to mothers with confirmed toxoplasmosis between 2019 and 2022. Newborns were classified as CT (n = 19) or non-CT (n = 25) based on serological follow-up, comparative Western blot (CWB) and Interferon Gamma Release Assay (IGRA). Sensitivity and specificity of CWB, IgM Chemiluminescent Immunoassay (CLIA), and IgM ISAGA were assessed at birth and at one month. At birth, CWB demonstrated 88.9% sensitivity, significantly higher than IgM CLIA (52.6%) and IgM ISAGA (57.9%). Specificity was 100% at birth and 92% at one month. CWB retained high sensitivity at one month (81.8%). IGRA complemented CWB in confirming or excluding infection in cases with equivocal or false-negative serology. Comparative Western blot thus represents a robust diagnostic alternative for CT, ensuring early detection and timely treatment, particularly in the absence of IgM ISAGA.
Publicações recentes
Congenital Toxoplasmosis With Atypical Neuroimaging: Hydrocephalus and Bilateral Chorioretinitis Without Intracranial Calcifications.
A Transient "Blueberry Muffin" Rash in a Neonate with Acute Myeloid Leukemia: A Case Report and Review of the Literature.
Nephrolithiasis associated with sulfadiazine therapy in an infant with congenital toxoplasmosis: a case report.
A safe and efficacious inactivated vaccine aids prevent reproductive failure associated with congenital toxoplasmosis in ovine.
Evaluating how demography and temperature increase might alter the burden of congenital Toxoplasmosis in Africa.
📚 EuropePMC1.379 artigos no totalmostrando 196
A safe and efficacious inactivated vaccine aids prevent reproductive failure associated with congenital toxoplasmosis in ovine.
Veterinary researchEvaluating how demography and temperature increase might alter the burden of congenital Toxoplasmosis in Africa.
PLoS neglected tropical diseasesSeroprevalence and Genotype Distribution of Toxoplasma gondii Among Pregnant Women in Northwest Ethiopia: A Cross-Sectional Study.
Health science reports[Use of antiparasitic drugs in the prevention of congenital toxoplasmosis: systematic review and meta-analysis].
Medecine tropicale et sante internationaleComparative IgG-IgM Western Blot in the Diagnosis of Congenital Toxoplasmosis: A Valid Diagnostic Tool.
Pathogens (Basel, Switzerland)Maternal, Behavioral, and Environmental Factors Associated with Toxoplasma gondii Infection in Pregnancy in Italy: A Case-Control Study.
Diagnostics (Basel, Switzerland)Cytokines and inflammatory mediators in amniotic fluid as predictive markers of congenital infections.
European journal of obstetrics, gynecology, and reproductive biologySevere congenital toxoplasmosis with isolated central hypothyroidism: A rare case report.
Journal of neonatal-perinatal medicineCongenital toxoplasmosis in Martinique: Clinical features and Caribbean genotypes in a comparative study with mainland France.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious DiseasesPrevalence and Risk Factors for Congenital Toxoplasmosis in Newborns in the Public Health System in the Eastern Region of the Brazilian Amazon, Northern Tocantins State, Brazil: Retrospective Cohort Study.
Tropical medicine and infectious diseaseUsing dried blood spots to estimate Toxoplasma gondii seroprevalence in pregnant women in Catalonia, Spain, and to serologically diagnose congenital toxoplasmosis.
PLoS neglected tropical diseasesFatal Congenital Toxoplasmosis with Progressive Liver Failure and Genomic Characterization of a Novel Isolate from the United States.
MicroorganismsToxoplasma gondii infection inhibits invasion and migration of human extravillous trophoblasts through dysregulation of FOXO1- and FOXO3a-dependent and -independent mechanisms.
Frontiers in cellular and infection microbiologyNovel drug candidates targeting Toxoplasma gondii in maternal-fetal interface models.
Frontiers in pharmacologySeroprevalence and incidence of Toxoplasma gondii infection in pregnant women in the health care area of Santiago de Compostela (NW Spain): 2015-2022.
Enfermedades infecciosas y microbiologia clinica (English ed.)Protein characterization of the IgM triplet involved in the diagnosis of congenital toxoplasmosis.
Parasite (Paris, France)Therapeutic potential of spiramycin-nanoparticles and Aluvia in experimental congenital toxoplasmosis.
Experimental parasitologyThe role of blood nested B1-gene in differentiation of acute toxoplasmosis from chronic infection during pregnancy.
Journal of parasitic diseases : official organ of the Indian Society for ParasitologyCaffeic acid reduces Toxoplasma gondii proliferation in human extravillous trophoblast cells (HTR8/SVneo) through induction of pro-inflammatory cytokines and a death process suggestive of apoptosis.
Microbes and infectionToxoplasmosis in the Era of Targeted Immunotherapy: A Systematic Review of Emerging Cases Linked to Biologics and Small Molecules in Autoimmune Diseases, Oncology and Transplantation.
Pathogens (Basel, Switzerland)Treatment outcomes for gestational toxoplasmosis in India with an emphasis on periconceptional infection in a prospective study.
Scientific reportsSNPs at the IL-2, IL-12, TNF-α and TGF-β1 regulatory gene regions are probably important for Toxoplasma gondii congenital transmission and disease severity in humans.
Microbes and infectionMulticenter performance evaluation of the "quanty TOXO (RH region)" kit (Clonit) for molecular diagnosis of toxoplasmosis.
Journal of clinical microbiologyAdherence to the Colombian guideline on congenital toxoplasmosis.
Biomedica : revista del Instituto Nacional de SaludToxoplasmosis in pregnancy; analysis of maternal seropositivity in a large cohort in Turkey and clinical consequences of neonates.
MedicineThe Prevalence of Toxoplasmosis Antibodies Among Pregnant Women Attending Antenatal Care Services in Urban and Rural Health Facilities in Three Regions of Burkina Faso: A Cross-Sectional Study.
Health science reportsSeroprevalence and associated behavioral factors of Toxoplasma gondii infection among pregnant women in Pokhara Valley, Nepal.
Tropical medicine and healthDifferential Expression of hsa-miR-144-3p and hsa-miR-125b-5p in Gestational Toxoplasmosis.
Parasite immunologyBthTX-II, an Asp49 PLA2 from Bothrops jararacussu, Impairs Toxoplasma gondii Infection: In Vitro and Ex Vivo Approaches.
Pharmaceuticals (Basel, Switzerland)Challenges in Diagnosis of Congenital Toxoplasmosis on Postimplementation of Minas Gerais Screening Program.
The Pediatric infectious disease journalCellular immune response during Toxoplasma gondii infection: deciphering diverse population immune variations.
Trends in parasitologyEstimating the national seroprevalence of Toxoplasma gondii infection in pregnant women, France 2021.
Epidemiology and infectionAssessing the burden of congenital toxoplasmosis in Burundi, 2020.
Acta tropicaToxoplasma gondii seroprevalence and associated factors among pregnant women attending their first antennal care visit in rural Burkina Faso.
Journal of parasitic diseases : official organ of the Indian Society for ParasitologyEfficacy of Heterologous Vaccination Using Virus-Like Particles and Vaccinia Virus Containing MIC8 and AMA1 Proteins of Toxoplasma gondii.
VaccinesEmerging Trends in Toxoplasmosis Seroepidemiology in Childbearing-Aged Women in Croatia, 2015-2024.
Pathogens (Basel, Switzerland)Brazilian Red Propolis and Its Active Constituent 7-O-methylvestitol Impair Early and Late Stages of Toxoplasma gondii Infection in Human Placental Models.
MicroorganismsPrevalence, risk factors, diagnosis and outcomes of Toxoplasma gondii infection in pregnancy: A review.
Parasitology internationalWill we miss specific IgA detection for the diagnosis of congenital toxoplasmosis? A French retrospective monocenter study on 483 infants.
Journal of clinical microbiologyCongenital toxoplasmosis.
Seminars in pediatric neurologyCongenital toxoplasmosis: an observational retrospective study in the Eastern Sicily.
Frontiers in pediatricsPotential bias in the analysis of prenatal treatment for congenital toxoplasmosis.
PLoS neglected tropical diseasesToxoplasma gondii infection risk among pregnant people and congenital toxoplasmosis incidence in Japan.
Epidemiology and infectionPrenylated chalcone analog-mediated Inhibition of Toxoplasma gondii growth in human trophoblast cell line and villous explants.
Scientific reportsToxoplasma gondii seroprevalence, seroconversion rates and genetic variability in humans from Uruguay.
ParasitologyThe effectiveness of congenital toxoplasmosis treatment in minimizing hearing loss: A systematic review.
Science progress[Congenital Toxoplasmosis, What is Important for Israeli Doctors to Know?].
HarefuahBilateral macular colobomata: expanded phenotype of PCARE/C2ORF71.
Ophthalmic geneticsEpidemiological changes in Toxoplasma infection: a 7-year longitudinal study in pregnant women in Lyon, France, 2017-2023.
Parasite (Paris, France)Treatment Protocols for Gestational and Congenital Toxoplasmosis: A Systematic Review and Meta-Analysis.
MicroorganismsIntercellular adhesion molecule (ICAM)-1 is required to control Toxoplasma gondii infection in uterine tissues and establish a successful gestation in a murine model of congenital toxoplasmosis.
PlacentaWaardenburg syndrome: a unique presentation with unilateral choroidal hypopigmentation and bilateral congenital toxoplasmosis scars.
BMJ case reportsRisk of Congenital Toxoplasmosis in Newborns from Mothers with Documented Infection: Experience from Two Referral Centres.
Pathogens (Basel, Switzerland)[CONGENITAL TOXOPLASMOSIS: AWARENESS ENABLES PREVENTION, EARLY TREATMENT, AND IMPROVED OUTCOME].
HarefuahMjTX-II, a Lys49-PLA2 from Bothrops moojeni snake venom, restricts Toxoplasma gondii infection via ROS and VEGF regulation.
Chemico-biological interactionsToxoplasmosis Knowledge and Preventive Behaviours Among Pregnant Women in Jeddah, Saudi Arabia: A Cross-Sectional Study.
Healthcare (Basel, Switzerland)Impact of Experimental Congenital Toxoplasmosis on the Thyroid Gland: Histopathological and Immunobiochemical Indices Assessment.
Acta parasitologicaCongenital toxoplasmosis in infants from chronically infected mothers: report of two cases.
Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao PauloEfficacy of Clindamycin in Preventing Abortion and Vertical Transmission of Toxoplasma gondii (PRU Strain) Infection in Pregnant BALB/c Mice.
Iranian journal of pharmaceutical research : IJPRToxoplasma gondii from Gabonese forest, Central Africa: First report of an African wild strain.
PLoS neglected tropical diseasesTreatment with BKI-1748 after Toxoplasma gondii systemic dissemination in experimentally infected pregnant sheep improves fetal and lamb mortality and morbidity and prevents congenital infection.
Antimicrobial agents and chemotherapyThe Evaluation of Ocular Posterior Segment Findings in 5527 Term Infants Using Smartphone-Based Fundus Imaging.
Journal of ophthalmologyCurrent and Emerging Techniques for Diagnosis of Toxoplasmosis in Pregnancy: A Narrative Review.
Iranian journal of parasitologyCongenital Toxoplasmosis: Fewer Clinical Signs at 3 Years of Age Over the Last 15 Years but Stable Risk of Materno-fetal Transmission.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaGalectin-3 plays a key role in controlling infection by Toxoplasma gondii in human trophoblast cells and human villous explants.
Frontiers in cellular and infection microbiologyClinical characteristics of toxoplasmosis patients in Korea: A retrospective study using health insurance review and assessment service data and electronic medical records.
Parasites, hosts and diseasesSpatial pattern of congenital toxoplasmosis incidence and its relationship with vulnerability and national health indicators in Brazil.
Spatial and spatio-temporal epidemiologyDiseases Caused by and Behaviors Associated with Toxoplasma gondii Infection.
Pathogens (Basel, Switzerland)Increase in Congenital Toxoplasmosis During the COVID-19 Pandemic in the US.
Pathogens (Basel, Switzerland)Seroprevalence of Toxoplasma gondii and Associated Risk Factors in Pregnant Women in Araçatuba, São Paulo, Brazil: A Multi-Level Analysis.
MicroorganismsMolecular Biology for Diagnosis of Congenital and Neonatal Infections in the Cerebrospinal Fluid of Newborns from a Brazilian Tertiary Hospital.
MicroorganismsEfficacy of amniotic fluid, blood and urine samples for the diagnosis of toxoplasmosis in pregnant women candidates for amniocentesis using serological and molecular techniques.
BMC pregnancy and childbirthTeratogenic parasites: disease mechanisms and emerging study models.
Trends in parasitologyClinical outcomes of pediatric patients with congenital toxoplasmosis in a fourthlevel center Introduction. Congenital.
Biomedica : revista del Instituto Nacional de SaludDigital Narratives: The Impact of Instagram® on Mothers of Children with Congenital Toxoplasmosis.
Children (Basel, Switzerland)REIV-TOXO Project: Results from a Spanish cohort of congenital toxoplasmosis (2015-2022). The beneficial effects of prenatal treatment on clinical outcomes of infected newborns.
PLoS neglected tropical diseasesMicrocephaly Resulting From Congenital Toxoplasmosis: What the Radiologist can Expect to See? A Case Report.
Radiology case reportsA Comprehensive Bibliometric Analysis of Research Trends About Congenital Toxoplasmosis.
Turkiye parazitolojii dergisiEnhanced clindamycin delivery using chitosan-coated niosomes to prevent Toxoplasma gondii strain VEG in pregnant mice: an experimental study.
Tropical medicine and healthToxoplasma Gondii in humans, animals and in the environment in Morocco: a literature review.
Gut pathogensInflammatory pathways of Toxoplasmagondii infection in pregnancy.
Travel medicine and infectious diseaseDetection of Congenital Toxoplasmosis and Cytomegalovirus Infections Using Paired Sample Serodiagnosis from Suspected Cases at a Tertiary Teaching Hospital in Malaysia.
The Malaysian journal of medical sciences : MJMSEvaluation of the efficacy of Chitosan nanoparticles based on Rosuvastatin in the treatment of acute toxoplasmosis: An In vitro and In vivo study.
Microbial pathogenesisEvaluation of different cut-off points for IgG avidity and IgM in the diagnosis of acute toxoplasmosis in pregnant women participating in a congenital toxoplasmosis screening program.
Revista do Instituto de Medicina Tropical de Sao PauloInterleukins IL33/ST2 and IL1-β in Intrauterine Growth Restriction and Seropositivity of Anti-Toxoplasma gondii Antibodies.
MicroorganismsOne Health Approach to Toxoplasmosis: Owner and Dog Seropositivity as Spatial Indicators of Risk Areas for Acquired, Gestational and Congenital Transmission.
Tropical medicine and infectious diseaseCCR2-dependent placental migration of inflammatory monocytes suppresses abnormal pregnancies caused by Toxoplasma gondii infection.
International immunologyMedical termination of pregnancy with digoxin in a patient affected by severe congenital toxoplasmosis.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and ObstetricsBiological screening for congenital toxoplasmosis in newborns from Jataí, Goiás, Brazil: a cross-sectional study.
Revista da Escola de Enfermagem da U S PDetection of Toxoplasma gondii infection in buffaloes (Bubalus bubalis) and cattle (Bos taurus) at the Tabriz abattoir, Iran.
Veterinary medicine and scienceKnowledge Gaps and Educational Opportunities in Congenital Toxoplasmosis: A Narrative Review of Brazilian and Global Perspectives.
Tropical medicine and infectious diseaseA Rare Case of Unilateral Fetal Cataract and Coincidental Polydactyly in Congenital Toxoplasmosis.
CureusThe prevention of congenital toxoplasmosis using a combination of Spiramycin and Cotrimoxazole: The long-time experience of a tertiary referral centre.
Tropical medicine & international health : TM & IHMolecular diagnosis of human toxoplasmosis: the state of the art.
Journal of parasitic diseases : official organ of the Indian Society for ParasitologyNovel paradigm enables accurate monthly gestational screening to prevent congenital toxoplasmosis and more.
PLoS neglected tropical diseasesIn defense of children's brain: reshuffling the laboratory toolbox for the diagnosis of congenital toxoplasmosis.
Journal of clinical microbiologyEmploying digital PCR for enhanced detection of perinatal Toxoplasma gondii infection: A cross-sectional surveillance and maternal-infant outcomes study in El Salvador.
PLoS neglected tropical diseasesAnti-Toxoplasma gondii activity of rose hip oil-solid lipid nanoparticles.
Food science & nutritionToxoplasma gondii Infections and Associated Factors in Female Children and Adolescents, Germany.
Emerging infectious diseasesA systematic review and meta-analysis of the validation of serological methods for detecting anti-Toxoplasma gondii antibodies in humans and animals.
Veterinary parasitologyCongenital toxoplasmosis of the brain caused by infection in late pregnancy.
Lancet (London, England)Multicenter evaluation of the Toxoplasma gondii Real-TM (Sacace) kit performance for the molecular diagnosis of toxoplasmosis.
Journal of clinical microbiologyLong-term Ocular Outcomes in Congenital Toxoplasmosis Treated Perinatally.
PediatricsCongenital Toxoplasmosis and Long-term Outcomes.
Turkiye parazitolojii dergisiSystematic Review and Meta-Analysis of Congenital Toxoplasmosis Diagnosis: Advances and Challenges.
Journal of tropical medicineDiagnosis of Congenital Toxoplasmosis: Challenges and Management Outcomes.
CureusChronic Toxoplasma gondii Infection Modulates Hearing Ability across the Adult Life Span.
Life (Basel, Switzerland)A Rare Case of a Subgaleal Hematoma With Global Developmental Delay, Scurvy, and Congenital Toxoplasmosis, Rubella, Cytomegalovirus, Herpes Simplex, and HIV (TORCH) Infection.
CureusGenetic characterization of Toxoplasma gondii from human and chicken isolates from Argentina.
Parasitology researchCongenital toxoplasmosis and auditory disorders: a literature review.
Frontiers in psychologyResults of the REIV-TOXO national survey on prenatal screening for toxoplasmosis in Spain.
Enfermedades infecciosas y microbiologia clinica (English ed.)Could PLATELIA Toxo IgM be the new gold standard for the serological diagnosis of congenital toxoplasmosis: a French multicenter study.
Journal of clinical microbiologyCongenital toxoplasmosis and audiological outcome: from a case series to a suggestion of patient-based schedule.
Frontiers in pediatricsToxoplasma gondii Infection in Pregnancy - Recommendations of the Working Group on Obstetrics and Prenatal Medicine (AGG - Section on Maternal Disorders).
Geburtshilfe und FrauenheilkundeA novel mRNA vaccine, TGGT1_278620 mRNA-LNP, prolongs the survival time in BALB/c mice with acute toxoplasmosis.
Microbiology spectrumReduced neural progenitor cell count and cortical neurogenesis in guinea pigs congenitally infected with Toxoplasma gondii.
Communications biologyToxoplasma gondii IgG avidity for the diagnosis of primary infection in pregnant women: Comparison between chemiluminescent microparticle immunoassay and enzyme-linked immunosorbent assay.
Journal of infection and chemotherapy : official journal of the Japan Society of ChemotherapyComparison of B1 and RE 529 gene targets by real time PCR and LAMP assay for diagnosis of toxoplasmosis in pregnant females.
Indian journal of medical microbiologyRecent and past toxoplasmosis infections, associated factors, and awareness among pregnant women in Nigeria.
SAGE open medicineTrypanosoma cruzi P21 recombinant protein modulates Toxoplasma gondii infection in different experimental models of the human maternal-fetal interface.
Frontiers in immunologyAn Early Treatment With BKI-1748 Exhibits Full Protection Against Abortion and Congenital Infection in Sheep Experimentally Infected With Toxoplasma gondii.
The Journal of infectious diseasesSeroepidemiology of toxoplasmosis in pregnant women and detection of infection acquired during pregnancy in Cotonou, Benin.
Parasite (Paris, France)Gestational toxoplasmosis treatment changes the child's prognosis: A cohort study in southern Brazil.
PLoS neglected tropical diseasesToxoplasmosis Screening during Pregnancy in a Romanian Infectious Diseases Tertiary Center: Results of a 15 Years Follow-Up Program.
MicroorganismsBuilding Programs to Eradicate Toxoplasmosis Part III: Epidemiology and Risk Factors.
Current pediatrics reportsReal-time PCR in the diagnosis of congenital toxoplasmosis.
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesToxoplasma gondii Induces Pyroptosis in Human Placental Trophoblast and Amniotic Cells by Inducing ROS Production and Activation of Cathepsin B and NLRP1/NLRP3/NLRC4/AIM2 Inflammasome.
The American journal of pathologyContribution of serology in congenital toxoplasmosis diagnosis: results from a 10-year French retrospective study.
Journal of clinical microbiologyRottlerin impairs early and late steps of Toxoplasma gondii infection in human trophoblast cells and villous explants.
Chemico-biological interactionsBoth C57BL/KsJ (H2d haplotype) and CB10-H2 (H2b haplotype) mice are highly susceptible to congenital toxoplasmosis.
Acta tropicaAuthor Correction: Congenital toxoplasmosis among hospitalized infants in Poland in the years 2007-2021: study based on the national hospital registry.
Scientific reportsNew Allele-Specific Oligonucleotide (ASO) amplifications for Toxoplasma gondii rop18 allele typing: Analysis of 86 human congenital infections in Brazil.
Acta tropicaMaternal Toxoplasma gondii infection affects proliferation, differentiation and cell cycle regulation of retinal neural progenitor cells in mouse embryo.
Frontiers in cellular neuroscienceQuantitative Risk Assessment of Oocyst Versus Bradyzoite Foodborne Transmission of Toxoplasma gondii in Brazil.
Pathogens (Basel, Switzerland)Seroprevalence of Toxoplasma gondii and associated risk factors for infection in the Netherlands: third cross-sectional national study.
Epidemiology and infectionUnspecific congenital toxoplasmosis in a two-month-old baby.
Acta bio-medica : Atenei ParmensisCongenital toxoplasmosis among hospitalized infants in Poland in the years 2007-2021: study based on the national hospital registry.
Scientific reportsSimultaneous seroprevalence of Toxoplasma gondii and rubella virus infections in pregnant women in Dakar (Senegal).
Tropical parasitologyCongenital Toxoplasmosis Diagnosis: Current Approaches and New Insights.
Acta parasitologicaIgM triplet in neonatal diagnosis by immunoblotting and its potential use as a diagnostic marker for congenital toxoplasmosis.
Parasite (Paris, France)[Seroprevalence and risk factors for congenital toxoplasmosis in the northeastern region of ColombiaSoroprevalência e fatores de risco associados à toxoplasmose gestacional no nordeste da Colômbia].
Revista CuidarteMaternal anti-Toxoplasma gondii antibodies IgG2, IgG3 and IgG1 are markers of vertical transmission and clinical evolution of toxoplasmosis in the offspring.
Acta tropicaNanoparticles as a Delivery System of Antigens for the Development of an Effective Vaccine against Toxoplasma gondii.
VaccinesPolyalthic acid and oleoresin from Copaifera trapezifolia Hayne reduce Toxoplasma gondii growth in human villous explants, even triggering an anti-inflammatory profile.
Experimental parasitologySerological diagnosis of toxoplasmosis in pregnancy: comparison between a manual commercial ELISA assay and the automated VIDAS® kit.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical MicrobiologySeroprevalence and risk factors of Toxoplasmosis among HIV infected women of child-bearing age attending care and treatment clinics in Dar es Salaam, Tanzania.
African health sciencesUpregulation of IL-33, CCL2, and CXCL16 levels in Brazilian pregnant women infected by Toxoplasma gondii.
Acta tropicaTemporal trend, spatial analysis and spatiotemporal clusters of infant mortality associated with congenital toxoplasmosis in Brazil: Time series from 2000 to 2020.
Tropical medicine & international health : TM & IHInfection of Mouse Neural Progenitor Cells by Toxoplasma gondii Reduces Proliferation, Migration, and Neuronal Differentiation in Vitro.
The American journal of pathologyBiallelic variants in TUBGCP6 result in microcephaly and chorioretinopathy 1: Report of four cases and a literature review.
American journal of medical genetics. Part AFirst description of congenital toxoplasmosis after maternal coinfection with Toxoplasma gondii and severe acute respiratory syndrome coronavirus 2: a case report.
Journal of medical case reportsRisk factors for recurrences and visual impairment in patients with ocular toxoplasmosis: A systematic review and meta-analysis.
PloS oneBuilding Programs to Eradicate Toxoplasmosis Part II: Education.
Current pediatrics reportsA large-scale study on the seroprevalence of Toxoplasma gondii infection in humans in Iran.
Folia parasitologicaToxoplasma gondii infections in pediatric neurosurgery.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryMaternal and congenital toxoplasmosis in Mayotte: Prevalence, incidence and management.
PLoS neglected tropical diseasesEstablishment of a murine model of congenital toxoplasmosis and validation of a qPCR assay to assess the parasite load in maternal and fetal tissues.
Frontiers in microbiology[Ocular manifestations of congenital toxoplasmosis].
Journal francais d'ophtalmologieBjussuLAAO-II, an l-amino acid oxidase from Bothrops jararacussu snake venom, impairs Toxoplasma gondii infection in human trophoblast cells and villous explants from the third trimester of pregnancy.
Microbes and infectionLeaf hydroalcoholic extract and oleoresin from Copaifera multijuga control Toxoplasma gondii infection in human trophoblast cells and placental explants from third-trimester pregnancy.
Frontiers in cellular and infection microbiologyToxoplasmosis: A Timeless Challenge for Pregnancy.
Tropical medicine and infectious diseaseToxoplasmosis Infection during Pregnancy.
Tropical medicine and infectious diseaseComparison of the prevalence of risk factors for Toxoplasma Gondii infection among pregnant women in rural and urban areas in Poland.
Przeglad epidemiologicznyCongenital toxoplasmosis with severe neurological disease in a referral hospital in Peru.
Revista peruana de medicina experimental y salud publicaEvaluation of the acceptability of point of care diagnostic test for prenatal toxoplasmosis (translational research phase III).
Journal of infection and public healthToxoplasma gondii infection in HIV-infected pregnant women: epidemiology and risks of mother-to-child transmission.
The Pan African medical journalImaging of Congenital/Childhood Central Nervous System Infections.
Neuroimaging clinics of North AmericaIs the incidence of congenital toxoplasmosis declining?
Trends in parasitologyA Systematic Review to Evaluate a Possible Association Between Congenital Toxoplasmosis and Preterm Labor.
The Pediatric infectious disease journalIdentification and multilocus genotyping of Toxoplasma gondii isolates from congenital infection in north of Iran.
Parasitology researchPresence of Toxoplasma gondii tissue cysts in human semen: Toxoplasmosis as a potential sexually transmissible infection.
The Journal of infectionEstimation of the morbidity and mortality of congenital Chagas disease: A systematic review and meta-analysis.
PLoS neglected tropical diseasesPrevention of congenital toxoplasmosis in France using prenatal screening: A decision-analytic economic model.
PloS oneDiagnostic accuracy of adjusted low IgG avidity index to predict acute Toxoplasma gondii infection in the first trimester of pregnancy.
Folia parasitologicaLong-Term Outcomes in Children with Congenital Toxoplasmosis-A Systematic Review.
Pathogens (Basel, Switzerland)Curcumin modulates neurogliogenesis and purinergic receptor expression in neural precursor cells infected with Toxoplasma gondii.
Parasitology researchThe epidemiology and disease burden of congenital TORCH infections among hospitalized children in China: A national cross-sectional study.
PLoS neglected tropical diseasesExploring the association between precipitation and population cases of ocular toxoplasmosis in Colombia.
PLoS neglected tropical diseases[Ocular toxoplasmosis in infants 0 to 12 months of age with congenital toxoplasmosis].
Revista chilena de infectologia : organo oficial de la Sociedad Chilena de InfectologiaAssociation of Proton Pump Inhibitor/Histamine-2 Blocker Use and Ocular Toxoplasmosis: Findings from a Large US National Database.
Ophthalmology. RetinaIsolation and characterization of Toxoplasma gondii isolates from human congenital toxoplasmosis cases reveal a new virulent genotype in São Paulo, Brazil.
Parasitology researchBuilding Programs to Eradicate Toxoplasmosis Part I: Introduction and Overview.
Current pediatrics reportsBuilding Programs to Eradicate Toxoplasmosis Part IV: Understanding and Development of Public Health Strategies and Advances "Take a Village".
Current pediatrics reportsVertical transmission and pathological findings in the mother, the placenta and the offspring, during first and last thirds of gestation in a mouse model of congenital toxoplasmosis.
Parasitology internationalCongenital Toxoplasmosis: The State of the Art.
Frontiers in pediatricsDiscordant Congenital Toxoplasmosis and Cytomegalovirus Infection in Dichorionic Diamniotic Twins.
The Pediatric infectious disease journalSpontaneous abortion among Toxoplasma gondii IgG seropositive women: Molecular detection, genotype identification, and serological assessment with conventional ELISA and avidity ELISA.
The journal of obstetrics and gynaecology researchCongenital Co-infections Among HIV-Exposed Infants Born to Mothers on Antiretroviral Treatment in the United States.
Frontiers in pediatricsCongenital toxoplasmosis: Should we still care about screening?
Food and waterborne parasitologySpecific antibody titer decay in neonates prenatally exposed to Toxoplasma gondii and their mothers.
Italian journal of pediatricsDiagnosis of Congenital Toxoplasmosis: No Benefit of IgA Antibody Detection by Platelia ELISA in a Tricentric Evaluation.
Journal of clinical microbiologyDiagnosis of Congenital Toxoplasmosis: Performance of Four IgG and IgM Automated Assays at Birth in a Tricentric Evaluation.
Journal of clinical microbiologyTNFα rs1799964 TT genotype may be a susceptibility factor for vertical transmission of Toxoplasma gondii and clinical signs in newborns from pregnant women with acute toxoplasmosis.
Molecular biology reportsAnalysis of Preventable Risk Factors for Toxoplasma gondii Infection in Pregnant Women: Case-Control Study.
Journal of clinical medicineSpyramicine and Trimethoprim-Sulfamethoxazole Combination to Prevent Mother-To-Fetus Transmission of Toxoplasma gondii Infection in Pregnant Women: A 28-Years Single-center Experience.
The Pediatric infectious disease journalCongenital ocular toxoplasmosis in consecutive siblings.
Arquivos brasileiros de oftalmologiaAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Evaluating how demography and temperature increase might alter the burden of congenital Toxoplasmosis in Africa.
- Seroprevalence and Genotype Distribution of Toxoplasma gondii Among Pregnant Women in Northwest Ethiopia: A Cross-Sectional Study.
- Using dried blood spots to estimate Toxoplasma gondii seroprevalence in pregnant women in Catalonia, Spain, and to serologically diagnose congenital toxoplasmosis.
- A safe and efficacious inactivated vaccine aids prevent reproductive failure associated with congenital toxoplasmosis in ovine.
- Comparative IgG-IgM Western Blot in the Diagnosis of Congenital Toxoplasmosis: A Valid Diagnostic Tool.
- Congenital Toxoplasmosis With Atypical Neuroimaging: Hydrocephalus and Bilateral Chorioretinitis Without Intracranial Calcifications.
- A Transient "Blueberry Muffin" Rash in a Neonate with Acute Myeloid Leukemia: A Case Report and Review of the Literature.
- Nephrolithiasis associated with sulfadiazine therapy in an infant with congenital toxoplasmosis: a case report.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:858(Orphanet)
- MONDO:0005715(MONDO)
- GARD:18708(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Q5413808(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
