Raras
Buscar doenças, sintomas, genes...
Embriofetopatia tóxica ou relacionada com fármacos
ORPHA:251529CID-10 · O35.5CID-11 · LD2F.0DOENÇA RARA

Anomalias congênitas causadas por substâncias medicinais ou drogas de abuso administradas ou tomadas pela mãe, ou às quais ela é exposta inadvertidamente durante a fabricação de tais substâncias. O conceito exclui anomalias resultantes da exposição a produtos químicos não medicinais no ambiente.

Mantido por Agente Raras·Colaborar como especialista →

Introdução

O que você precisa saber de cara

📋

Anomalias congênitas causadas por substâncias medicinais ou drogas de abuso administradas ou tomadas pela mãe, ou às quais ela é exposta inadvertidamente durante a fabricação de tais substâncias. O conceito exclui anomalias resultantes da exposição a produtos químicos não medicinais no ambiente.

🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: O35.5
Você se identifica com essa condição?
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

😀
Face
30 sintomas
🦴
Ossos e articulações
30 sintomas
👁️
Olhos
15 sintomas
🧠
Neurológico
14 sintomas
❤️
Coração
13 sintomas
👂
Ouvidos
11 sintomas

+ 83 sintomas em outras categorias

Características mais comuns

Holoprosencefalia
Reflexos tendíneos reduzidos
Fenda palatina mediana
Nariz bífido
Fenda facial
Polidactilia do pé
232sintomas
Sem dados (232)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 232 características clínicas mais associadas, ordenadas por frequência.

HoloprosencefaliaHoloprosencephaly
Reflexos tendíneos reduzidosReduced tendon reflexes
Fenda palatina medianaMedian cleft palate
Nariz bífidoBifid nose
Fenda facialFacial cleft

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1
Últimos 10 anos200publicações
Pico2026197 papers
Linha do tempo
2025Hoje · 2026
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Embriofetopatia tóxica ou relacionada com fármacos

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

Pesquisa e ensaios clínicos

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Publicações mais relevantes

Timeline de publicações
0 papers (10 anos)
#1

Striking the right balance with type I interferon signalling in cancer.

Nature reviews. Cancer2026 Mar 23

Interferons tipo I (IFNs) são importantes na terapia contra o câncer, pois fortalecem a imunidade antitumoral e melhoram a eficácia de outros tratamentos, mas seu uso é limitado por toxicidade e resultados inconsistentes. Este artigo destaca a complexidade da ação dos IFNs, que podem ter efeitos tanto benéficos quanto prejudiciais no tumor, dependendo de diversos fatores. O objetivo da pesquisa é entender profundamente esses mecanismos para reprogramar a atividade dos IFNs, buscando otimizar as terapias oncológicas e torná-las mais eficazes e com menos efeitos adversos para os pacientes.

🇧🇷 traduzido
#2

The TCR in CAR T cell therapy: use it or lose it?

Cancer gene therapy2026 Mar 24

A terapia com células CAR T, embora vital para alguns cânceres do sangue, ainda enfrenta desafios como persistência limitada, alto custo e toxicidades, especialmente em tumores sólidos. Este artigo explora o papel do receptor de célula T (TCR) natural nas células CAR T: se removê-lo as tornaria mais universais e acessíveis, ou se mantê-lo é crucial para a durabilidade e eficácia da terapia. Otimizar a decisão sobre o TCR é fundamental para desenvolver tratamentos CAR T mais seguros, duradouros e eficazes, beneficiando diretamente pacientes e médicos ao expandir as opções terapêuticas.

🇧🇷 traduzido
#3

miR-495-3p attenuates cerebral ischemia-reperfusion-induced neuronal inflammation and apoptosis by targeting CCL2 expression.

In vitro cellular & developmental biology. Animal2026 Mar 23

Este estudo investigou a lesão cerebral por isquemia e reperfusão (CI/RI), comum após eventos como AVC, e descobriu que a molécula miR-495-3p está anormalmente baixa nesse contexto, enquanto a CCL2 está elevada. Aumentar os níveis de miR-495-3p demonstrou reduzir significativamente a inflamação e a morte de neurônios, os principais responsáveis pelo dano cerebral, agindo através da regulação de CCL2. Para pacientes e médicos, estes achados são promissores, pois sugerem que a miR-495-3p pode ser um novo alvo terapêutico para desenvolver medicamentos que protejam o cérebro, diminuam a inflamação e a perda neuronal, e potencialmente melhorem o prognóstico e minimizem sequelas em pessoas que sofrem de lesões cerebrais por isquemia e reperfusão.

🇧🇷 traduzido
#4

Dual targeting of PI3Kδ and PPARα enhances antitumor activity via FoxO1 activation in follicular lymphoma.

Cell death & disease2026 Mar 23

Para superar a resistência frequentemente observada no tratamento do linfoma folicular (FL) com inibidores de PI3Kδ, este estudo apresenta uma estratégia combinada promissora. A junção de um inibidor de PI3Kδ (linperlisib) com um agonista de PPAR (chiglitazar) demonstrou forte atividade antitumoral em modelos de FL, sendo superior às terapias únicas e com boa tolerabilidade. Além disso, a reativação da proteína FoxO1 é crucial para a eficácia, podendo servir como um importante biomarcador para prever a resposta e orientar futuras avaliações clínicas.

🇧🇷 traduzido
#5

Continuous evolution of a halogenase enzyme with improved solubility and activity for sustainable bioproduction.

Nature communications2026 Mar 24

A halogenação é fundamental para a estabilidade e função de muitos fármacos, mas os métodos químicos tradicionais são problemáticos e tóxicos. Este estudo apresenta a RebHEvo4, uma enzima halogenase evoluída que permite a produção altamente eficiente e site-específica de compostos halogenados. Para pacientes e médicos, isso significa um avanço significativo na biomanufatura sustentável de medicamentos halogenados, incluindo novos peptídeos antimicrobianos, tornando-os potencialmente mais acessíveis, seguros e eficazes.

🇧🇷 traduzido

Publicações recentes

📚 EuropePMCmostrando 199

2026

An update on the pharmacokinetic and pharmacodynamic interactions between antidepressants and antiseizure medications.

Expert opinion on drug metabolism & toxicology
2026

Engineering a Tyrosol-Responsive Dynamic System in Saccharomyces cerevisiae for Adaptive Regulation of Hydroxytyrosol Biosynthesis.

Journal of agricultural and food chemistry
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Phytochemical-based nanomedicine as a promising therapeutic strategy for erectile dysfunction.

Asian journal of andrology
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Molecular cancer therapeutics
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Harnessing the gut microbiota in extra-intestinal cancers: from causal evidence to immunotherapy strategies.

Immunotherapy
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Photocaged Chloroquine Derivatives for the Light-Dependent Inhibition of Autophagy in Cancer Stem Cells.

ACS chemical biology
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Extracellular Vesicles in Drug Delivery: From Quality Assurance to Therapeutic Application.

International journal of nanomedicine
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Intranasal Nano-Delivery Systems: Emerging Strategies for Central Nervous System Disease Therapeutics.

International journal of nanomedicine
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Successful Treatment of Acanthamoeba Keratitis Using 0.08% Polyhexamethylene Biguanide Monotherapy: A Report of a Case in Latin America.

Cureus
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Infertility and Hematologic Malignancies in Low-Resource Settings: Challenges and Perspectives.

Cureus
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Geraniol Mitigates Cytarabine-Induced Hepatotoxicity in Mice via PI3K/AKT-Mediated NRF2 Activation.

Journal of biochemical and molecular toxicology
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Discovery of ferulic acid carbamate derivatives as dual-targeting agents of BuChE and Nrf2 for Alzheimer's disease.

Journal of enzyme inhibition and medicinal chemistry
2026

[Characteristics and antimicrobial activities of selenium nanoparticles biosynthesized by selenium-tolerant yeast].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology
2026

[Optimization of microbial production process of γ-polyglutamic acid and research progress in its application in agriculture].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology
2026

Nanoscaffold-based 3D human liver spheroids for predictive hepatotoxicity screening of antimalarial compounds from the global health priority box.

Parasites & vectors
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Diabetes mellitus in ECOWAS: an overview of the safety and efficacy of medicinal plants used in traditional medicine practices.

Tropical medicine and health
2026

Real-world data on toxic anterior segment syndrome.

Journal of cataract and refractive surgery
2026

In Vitro and In Silico DNA Binding Studies of Novel 1,2,3-Triazole-Based Coumarin Compounds.

Chemistry & biodiversity
2026

Striking the right balance with type I interferon signalling in cancer.

Nature reviews. Cancer
2026

Efficacy of Aminocaproic Acid in Preventing Postoperative Hematoma in Breast Cancer Surgery: A Prospective Study.

Journal of surgical oncology
2026

Mechanistic Insights into pH-Responsive Drug Release and Antitumor Effects of an Albumin-Pirarubicin Conjugate.

Pharmaceutical research
2026

Employment status and food insecurity in cancer survivorship: evidence from the medical expenditure panel survey.

Cancer causes & control : CCC
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Aluminium, copper, nickel, lead and zinc in e-liquids from contemporary disposable vapes.

Environmental monitoring and assessment
2026

Source-sink relationships and health risk assessment of heavy metals in farmland soils of a Southwest Karst Industrial cluster: based on PMF and Monte Carlo simulation.

Environmental geochemistry and health
2026

The TCR in CAR T cell therapy: use it or lose it?

Cancer gene therapy
2026

miR-495-3p attenuates cerebral ischemia-reperfusion-induced neuronal inflammation and apoptosis by targeting CCL2 expression.

In vitro cellular & developmental biology. Animal
2026

Dual targeting of PI3Kδ and PPARα enhances antitumor activity via FoxO1 activation in follicular lymphoma.

Cell death & disease
2026

Continuous evolution of a halogenase enzyme with improved solubility and activity for sustainable bioproduction.

Nature communications
2026

K16F/E22F Mutation Promotes Oligomerization and Alters β-Sheet Topology of Aβ16-22 Peptides: Insights from Molecular Dynamics Simulations.

ACS chemical neuroscience
2026

Trophic magnification and distribution of per-/polyfluoroalkyl substances (PFAS) in an AFFF-impacted aquatic food web.

Environmental toxicology and chemistry
2026

A method for embryo-larval development toxicity testing on an endemic and commercially important mussel, Perna canaliculus.

Environmental toxicology and chemistry
2026

Arbuscular Mycorrhizal Consortium Alleviates Chromium(VI) Stress and Enhances Seed Phytochemicals in Psoralea corylifolia L.

Plant science : an international journal of experimental plant biology
2026

Inhibition of voltage-dependent anion channel 1 aggregation protects pancreatic beta-cell mitochondria from glucose toxicity.

International journal of biological macromolecules
2026

Occurrence and Transplacental Transfer of Benzotriazole Ultraviolet Stabilizers in Maternal-Cord Serum and Association with Birth Outcomes.

Environmental pollution (Barking, Essex : 1987)
2026

Design of Molecularly Imprinted Nickel Ferrite Photocatalyst and Its Application in Peroxodisulfate-Triggered Phenol Degradation.

Environmental research
2026

Myeloperoxidase in the pathogenesis of sickle cell disease.

Archives of biochemistry and biophysics
2026

Seafood-Based Dietary Cadmium Exposure Triggers Physiological Stress and Gene Dysregulation in Zebrafish.

Environmental toxicology and pharmacology
2026

Nuclear and cytoskeletal structural alterations in human alveolar epithelial cells by solvent-extracted organic matter from PM2.5.

Environmental toxicology and pharmacology
2026

Metabolic pathway modulation and oxidative imbalance triggered by decamethylcyclopentasiloxane (D5) in zebrafish embryo.

Environmental toxicology and pharmacology
2026

Acute Oral Toxicity and Hepatic Responses to Paederia foetida Leaf Extract in Wistar Rats.

Journal of ethnopharmacology
2026

Diagnostics for priority bacterial pathogens: global gaps and research needs for curbing antimicrobial resistance in low-resource settings.

The Lancet. Microbe
2026

Gambogenic acid suppresses T cell proliferation via inhibition of ERK signaling pathway.

International immunopharmacology
2026

Tracking metal-containing particles in wastewater using single-particle ICP-MS.

Talanta
2026

Prognostic value of early Epstein-Barr Virus DNA response in patients with locoregionally advanced nasopharyngeal carcinoma.

Oral oncology
2026

Cardiac Safety Profiles of First-Generation vs. Second-Generation BTK Inhibitors: A Meta-Analysis.

The oncologist
2026

Design and Biological Evaluation of Novel Biphenyl-Dihydropyrimidinone Derivatives with Selective Anticancer and Non-Genotoxic Profiles.

Biochemistry and cell biology = Biochimie et biologie cellulaire
2026

Discovery of SD-965 as a Potent, Selective, and Efficacious STAT3 PROTAC Degrader.

Journal of medicinal chemistry
2026

Self-Assembled Nanomaterials for ER-Targeted Cancer Therapy: From Molecular Design to Therapeutic Applications.

Biomacromolecules
2026

Repurposing Drugs as Bacteroides fragilis BFT-3 Inhibitors in the Animal Infection Model Galleria mellonella.

Annals of the New York Academy of Sciences
2026

In silico designing of palbociclib loaded PLGA long-acting intramuscular injection for palliative therapy of HR+/HER2- metastatic breast cancer.

The Journal of pharmacy and pharmacology
2026

From plant pair to gastroprotection: chemical standardization and in vivo validation of Akebiae Fructus-Hoveniae semen against ethanol-mediated mucosal damage.

The Journal of pharmacy and pharmacology
2026

Identification of polyphenols as novel neuropilin-1 cendR pocket inhibitors to block SARS-CoV-2 entry and enhance variant resistance.

PloS one
2026

Elucidating the potential carcinogenic molecular mechanisms of parabens in head and neck squamous cell carcinoma through network toxicology and molecular docking.

PloS one
2026

The Regimen of Cladribine, Cytarabine, and Venetoclax (CAV) Induces Apoptosis in Acute Myeloid Leukemia Cells by Enhancing DNA Damage.

Journal of visualized experiments : JoVE
2026

Gabapentinoids and unexplained death in general practice: Case series and feasibility study arising from a critical incident.

The European journal of general practice
2026

Engineered Protein Nanoparticles Enable Targeted Topical Delivery of Upadacitinib for Enhanced Arthritis Therapy.

ACS applied bio materials
2026

Nanozyme-Mediated PROTACs Delivery for Targeted Protein Degradation and Ferroptosis Sensitization in Prostate Cancer.

Angewandte Chemie (International ed. in English)
2026

Assessment of chemotherapy dosing and regimen optimization in geriatric oncology patients diagnosed with solid organ malignancies.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners
2026

L. carnitine modulates oxidative stress, steroidogenic gene disturbance, and testicular histopathology induced by Bisphenol A in male rats.

Veterinary research communications
2026

Study of a lipid extract from Eryx snakes in rat adjuvant-induced arthritis under a therapeutic regimen: comparison with methotrexate and leflunomide.

Inflammopharmacology
2026

Persistent Financial Burden Among U.S. Cancer Survivors Despite Affordable Care Act Implementation: Implications for Survivorship Financial Education.

Journal of cancer education : the official journal of the American Association for Cancer Education
2026

Discovery of potent thymidine phosphorylase inhibitors from Euphorbia pulcherrima Willd. ex Klotzsch with experimental validation and computational analysis.

Journal of computer-aided molecular design
2026

Time and contamination level dependence of metal bioaccumulation and multibiomarker responses in fish: implications for biomonitoring.

Environmental monitoring and assessment
2026

In silico ADMET profiling and DNA interaction study of xanthoxylin: assessment of pBR322 DNA protection against oxidative damage.

Journal of biological physics
2026

Senescence as a Central Node in Alzheimer's Disease: Molecular Triggers, Cellular Effectors, and RNA-Based Interventions.

Neurochemical research
2026

Quantitative analysis and method validation of mirogabalin in postmortem blood and urine using liquid chromatography-tandem mass spectrometry.

Forensic toxicology
2026

Assessment of risks to the environment and human health associated with potentially toxic elements in the surface water and sediments in the mining-affected area.

Environmental geochemistry and health
2026

Accumulation of Potentially Toxic Elements and Bioindicator Potential of Necrophagous Flies in Exposed Municipal Wastes.

Archives of environmental contamination and toxicology
2026

2g/m2 Ara-c induced more favorable outcome than 1g/m2 Ara-c in CLAG treatment for refractory or relapsed acute myeloid leukemia without increase toxicity: a multicenter propensity score matching analysis.

Annals of hematology
2026

The respiratory health effects of heated tobacco product aerosols in a primary human airway epithelial cell model.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
2026

Major Missing Source of Alkylated Polycyclic Aromatic Hydrocarbon Emissions from Oil Spill Volatilization.

Environmental science & technology
2026

Safety, Distribution, and Pharmacokinetics of Biodegradable P(AAm-co-MAA) Nanogels Following Systemic Administration in Mice.

Journal of biomedical materials research. Part A
2026

Association of Prophylactic Intravenous Corticosteroid Premedication With Toxicity and Survival in Patients Receiving Enfortumab Vedotin for Locally Advanced or Metastatic Urothelial Carcinoma.

International journal of urology : official journal of the Japanese Urological Association
2026

Association between short-term radiation-induced toxicity and oncological outcomes in high-risk prostate cancer: a retrospective single-centre cohort study.

Acta oncologica (Stockholm, Sweden)
2026

Safety and efficacy of echinocandin antifungal agents in Candida albicans endophthalmitis.

Antimicrobial agents and chemotherapy
2026

Tunable low-rate genomic recombination with Cre-lox in Escherichia coli: a versatile tool for anoxic environmental biosensing and synthetic biology.

Applied and environmental microbiology
2026

Outstanding presence of New Delhi metallo-beta-lactamase in carbapenem-resistant Enterobacterales and exceptionally potent in vitro activity of cefiderocol and aztreonam-avibactam emphasises their immediate access in India.

Transactions of the Royal Society of Tropical Medicine and Hygiene
2026

SHED-derived exosomes ameliorate age-related osteoporosis by activating mitophagy in senescent bone marrow mesenchymal stem cells.

Nanomedicine (London, England)
2026

An Engineered Triple-Functional Nanoplatform for Effective Sepsis Therapy via Macrophage-Targeted Polo-like Kinase 1 Inhibition.

ACS nano
2026

Fabrication and sensing performance of a highly sensitive room-temperature NO₂ gas sensor based on few-layer Ti₃C₂ MXene/WO₃ nanoparticle composites.

Nanotechnology
2026

First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
2026

ToxPLTC: Peptide Toxicity Prediction by Integrating Pretrained T5 Protein Language Model and Text Convolutional Neural Network.

Journal of chemical information and modeling
2026

Biomimetic Nanoplatform for Targeted Glioblastoma Therapy via Concurrently Triggering GPX4/DHODH Mediated Ferroptosis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
2026

Characterization and hemocompatibility of poly (N-acryloyl-L-tryptophan) nanoparticles as targeting delivery carriers for vinblastine.

Journal of biomaterials applications
2026

Retention and mobility of phosphogypsum constituents in carbonate aquifer rock materials.

Environmental science. Processes & impacts
2026

Application and mechanistic research of novel therapeutic strategies in cisplatin-resistant small cell lung cancer.

Annals of medicine
2026

Case Report: Adjuvant radiation therapy for cardiac intimal sarcoma with long-term disease control.

Frontiers in oncology
2026

Exposure to per- and poly-fluoroalkyl substances and associations with embryo quality and adverse pregnancy outcomes: a prospective cohort study.

Frontiers in public health
2026

Research Progress on Copper Metabolism, Cuprotosis, and Their Regulatory Mechanism in Tumor Diagnosis and Treatment.

Cancer management and research
2025

Smart polymeric nanoparticles for targeted delivery and microenvironment-responsive therapy in pancreatic cancer.

Smart materials in medicine
2026

Verbenone-based selenophene derivatives as potential anti-cancer agents: synthesis and biological evaluation in 2D and 3D A549 cell models.

RSC medicinal chemistry
2026

Hybrid Hydrogels in Pain Management Application: A Comprehensive Review.

Clinical pharmacology : advances and applications
2026

Cadmium Exposure May Induce Potential Brain Tumour Initiation by Regulating SHH, GLI1, BMI1 and P53 in the SHH-GLI1 Cell Signalling Pathway.

Annals of neurosciences
2026

A Comprehensive Review of Nanotechnological Innovations in Cancer: from Molecular Pathways to Clinical Applications.

Journal of Cancer
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Incomplete Ascher's Syndrome Misdiagnosed as Eczema: A Case Report.

Clinical, cosmetic and investigational dermatology
2026

Lipid-Engineered Small-Sized Metal-Organic Frameworks for Targeted Delivery of Anlotinib in Lung Cancer Treatment.

International journal of nanomedicine
2026

How Effective are Nanotechnology-Based Therapeutics to Treat Autoimmune Diseases.

International journal of nanomedicine
2026

Liposome-Based Drug Delivery for Diabetes: Therapeutic Applications and a Nanomedicine Perspective on Diabetic Complications.

International journal of nanomedicine
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Thermoradiotherapy-Driven Enhancement of Cuproptosis by Copper-Nitroimidazole Based Nanoparticles.

International journal of nanomedicine
2026

Filamentous Phage for Therapeutic Applications in Non-Small Cell Lung Cancer and Brain Metastases: Recent Prospect.

International journal of nanomedicine
2026

Electron Irradiation Effects on N and Fe3+ Doped Carbon Dots and the Application in Radiotherapy of Lung Cancer.

International journal of nanomedicine
2026

pH-Sensitive Long-Circulating Nanoliposomes with CU1 for Effective Against Lung Cancer.

International journal of nanomedicine
2026

A Self-Assembling Nanomodulator for Synergistic Therapy of Intracerebral Hemorrhage.

International journal of nanomedicine
2026

Nanotechnology-Driven Cancer Therapies for Precision Oncology: Advances and Clinical Outlook.

International journal of nanomedicine
2026

Distinct immunologic patterns of response and resistance to anti-PD-1/PD-L1-based immunotherapy in patients with soft tissue sarcoma.

Frontiers in immunology
2026

Targeting the oxidative stress-neuroinflammation axis: the mechanism of arctigenin's broad-spectrum analgesia with limited side effects.

Frontiers in immunology
2026

The impact of chronic comorbidities on cancer immunoediting: challenges and opportunities for immunotherapies.

Frontiers in immunology
2026

Real-world safety profile of T-cell engagers: evidence from multi-database analysis with CAR-T comparisons.

Frontiers in immunology
2026

Efficacy and safety of adding immune checkpoint inhibitors to standard chemotherapy or chemoradiotherapy for advanced or recurrent cervical cancer: a meta-analysis.

Frontiers in immunology
2026

Inhibition of DDX5-Mediated G-Quadruplex Unwinding in the β-Catenin 5'-UTR by Magnesium Isoglycyrrhizinate Alleviates Chemotherapy-Induced Intestinal Injury.

Research (Washington, D.C.)
2026

Long-Term Control of Giant Retroperitoneal Liposarcoma by Proton Beam Therapy Combined With Hyperthermia: A Case Report and Literature Review.

Cureus
2026

Synchronous Extensive-Stage Small Cell Lung Cancer and Multiple Myeloma Detected by Marked Hypergammaglobulinemia.

Cureus
2026

Chemotherapy and the Skin: Understanding Dermatologic Side Effects.

Cureus
2026

Corticosteroid Taper Duration and Relapse Rate in Immune Checkpoint Inhibitor-Induced Pneumonitis: A Meta-Analysis.

Cureus
2026

Doxycycline-Induced Phototoxicity Localized to Vitiligo-Affected and Sun-Exposed Skin.

Cureus
2026

Acute Boric Acid Poisoning With Chronic Renal Failure Successfully Treated With Continuous Hemofiltration.

Cureus
2026

Feasibility study on the impact of mechanical recycling on the extractables profile and toxicologic safety assessment of small-scale polycarbonate bioreactors.

International journal of pharmaceutics: X
2026

Functional roles and mechanisms of NAT10-mediated RNA ac4C modification in normal development and cancer progression.

Frontiers in cell and developmental biology
2026

Lineage-Specific Disruption of Hematopoiesis by Oxaliplatin: Mechanisms of Erythropoietin Resistance and Immune Suppression.

Journal of hematology and oncology research
2026

Electro-acupuncture attenuates cyclophosphamide-induced premature ovarian insufficiency in rats through miRNA regulation and TGFβ/Smad pathway modulation.

American journal of translational research
2026

Phytochemical small molecules from Stauntonia chinensis DC as multi-target modulators: molecular mechanisms and therapeutic potential.

American journal of translational research
2026

Isolated immune-mediated enteritis in patients treated with immune checkpoint inhibitor therapy.

Annals of gastroenterology
2026

Multicenter dose de-escalation phase I trial of pressurized intraperitoneal aerosolized chemotherapy (PIPAC) nab-paclitaxel and cisplatin in combination with systemic nab-paclitaxel in recurrent ovarian cancer patients: trial in progress.

Pleura and peritoneum
2026

Endocrine Therapy versus Chemotherapy After CDK4/6 Inhibitor Progression in HR+/HER2- Metastatic Breast Cancer: A Multicenter Real-World Study from Turkey.

Breast cancer (Dove Medical Press)
2026

Phellinus linteus polysaccharides inhibit castration-resistant prostate cancer progression possibly via dual modulation of PIK3R1 and PGC-1α: a preclinical evaluation.

American journal of cancer research
2026

Biochar and nano-silicon partnership alleviates vanadium toxicity in rice through improving antioxidant defense, nitrogen assimilation and iron plaque formation.

Frontiers in plant science
2026

Cerium oxide nanoparticles enhance rice productivity by modulating nitric oxide signaling, carbon metabolism, and potassium homeostasis under chromium-induced environmental stress.

Frontiers in plant science
2026

New progress in the production, oxidative damage, and scavenging mechanisms of reactive oxygen species in plants under abiotic stress.

Frontiers in plant science
2026

Chemotherapy-Induced Toxicities in Pediatric Cancer Patients: A Cross-Sectional Survey Using a Child- and Caregiver-Reported Outcome Tool in Tanzania.

Drug, healthcare and patient safety
2026

The Hidden Perils of Allopurinol: A Systematic Review of Allopurinol-Induced DRESS (Drug Reaction With Eosinophilia and Systemic Symptoms) Syndrome.

Cureus
2026

Preliminary insights into intratesticular and intraepididymal administration of eugenol: histological alterations and impact on sperm motility in Wistar rats.

Animal reproduction
2026

Dual-Biosensor for Five Drugs Detection in Precision Oncology.

BioNanoScience
2026

Massart iron oxide nanoparticles in mechanobiology.

Nanoscale advances
2026

BSA-modified g-C3N4 nanosheets as a sustainable dual-purpose adsorbent for efficient Pb2+ removal and CO2 capture.

Nanoscale advances
2026

Transformation of 3-(4-methoxybenzylidine)-5-(p-tolyl)-2(3H)-furanone into new nitrogen heterocyclic candidates as insecticidal agents with in silico studies.

RSC advances
2026

Adsorptive and photocatalytic strategies for carmoisine removal: mechanisms, material innovations, and environmental implications.

RSC advances
2026

Green biosynthesis of selenium nanoparticles by Ralstonia insidiosa which demonstrate effectiveness against human cancer cells, Candida species and multidrug-resistant Acinetobacter baumannii.

RSC advances
2026

Two cases (a decade apart) of severe sulfonylurea-positive hypoglycemia associated with inhaled heroin use.

JCEM case reports
2026

Immunoinformatic insights for design and clinical prospects of pan-RAS cancer vaccine.

Frontiers in medicine
2026

Immunoinformatics-driven multi-epitope vaccine design targeting PSMA, STEAP1, and B7H3 for prostate cancer.

Frontiers in medicine
2026

Development of Membrane-Targeting Cannabigerol Derivatives as Potent Broad-Spectrum Antibacterial Agents.

Drug design, development and therapy
2026

Profiles of neuropsychiatric toxicity associated with different endocrine therapies for breast cancer: a global pharmacovigilance study based on FAERS and VigiAccess.

Frontiers in pharmacology
2026

Sex-related pharmacokinetic and pharmacological responses to 4F-furanylfentanyl.

Frontiers in pharmacology
2026

Pyrimidine nucleoside: inspiration for novel antimicrobial agent.

Frontiers in pharmacology
2026

Artificial intelligence modeling and investigation of metal organic frameworks in drug delivery: modeling of loading capacity and toxicity behavior.

Frontiers in chemistry
2026

ToxiVerse: A Public Platform for Chemical Toxicity Data Sharing and Customizable Predictive Modeling.

bioRxiv : the preprint server for biology
2026

Marine Algae as Sustainable Platforms for the Green Synthesis of Metal Nanoparticles.

ACS omega
2026

Functional Effects of Cyclization on Li1 Peptide Activity against Metacyclic Leishmania amazonensis Internalization.

ACS omega
2026

Paper-Based Microfluidics Platform for Enhanced On-Site Electrochemical Detection of Manganese in Water.

ACS omega
2026

Thermocatalytic Transformation of Nitriles Utilizing Pristine and Calcined ZnCr Layered Double Hydroxides for the Synthesis of Various Tetrazole- and Kynurenic Acid-Based Drug Candidates.

ACS omega
2026

Safety, Sedative, and Anxiolytic Evaluation of MECS Hard Capsules Using In Silico and In Vivo Approaches.

ACS omega
2026

Impact of age on outcomes after CD19 CAR T-cell therapy for large B-cell lymphomas.

Blood neoplasia
2026

Artificial Intelligence for Predicting Immunotherapy Efficacy in Non-Small Cell Lung Cancer.

Journal of inflammation research
2026

Case Report: Maculopathy following standard dose intracameral cefuroxime injection during ICL surgery.

Frontiers in ophthalmology
2026

Revolutionizing Food Safety: A Systematic Review of Nanotechnology-Based Aflatoxin Detection (2010-2023).

Nanotechnology, science and applications
2026

Sublethal Effects of the Insect Growth Regulator Novaluron on the Midgut Integrity and Survival of Adult Honey Bee Apis mellifera Workers.

ACS environmental Au
2026

Methodological Challenges in the Application of QSAR Models for Chemical Prioritization and Toxicity Assessment: A Case Study on Aryl Hydrocarbon Receptor Activity in Environmental Pollutant Mixtures.

ACS environmental Au
2025

Laboratory-Scale Reuse of Glass/ITO Substrates for Single Junction Perovskite Solar Cells.

ACS sustainable chemistry & engineering
2026

When Survival Improves But Quality of Life Does Not: A Model-Based Meta-Analysis of Immune Checkpoint Inhibitors.

medRxiv : the preprint server for health sciences
2026

An agentic AI system enhances clinical detection of immunotherapy toxicities: a multi-phase validation study.

medRxiv : the preprint server for health sciences
2026

Advancing pesticide risk assessment: the role of adverse outcome pathways and new approach methodologies - what's next?

Annali dell'Istituto superiore di sanita
2026

Biomonitoring and toxicological assessment of Ochratoxin A and Citrinin in a sex-gender perspective: The OTABioTox Project.

Annali dell'Istituto superiore di sanita
2025

Assessing Source Contributions to Air Quality and Noise in Unconventional Oil Shale Plays.

Research report (Health Effects Institute)
2026

Real-time monitoring of microplastic accumulation in fish bodies using transparent goldfish revealed initial attack on the gill.

Toxicology mechanisms and methods
2026

Overcoming barriers, driving progress: Clinical science at IAS 2025.

Journal of the International AIDS Society
2026

The Real-World Safety Profile of Temazepam: A 20-Year Pharmacovigilance Analysis Based on the Large-Scale FAERS Database.

CNS neuroscience & therapeutics
2026

Design and fabrication of plasmonic hedgehog-shaped covalent organic framework nanocomposites for indirect SERS-based ultradetection of water contaminant terbutryn.

Nanoscale
2026

ROS-activated oral enterosorbent nanogel to block gastrointestinal absorption of lead and cadmium: an in vitro study.

Toxicology mechanisms and methods
2026

Aging MPs in aquatic ecosystems: a review on occurrence, interactions, vector effects, and ecotoxicology.

Drug and chemical toxicology
2026

Femtomolar Congener-Selective Detection of Perfluoroalkyl Substances in Water by a Cyclodextrin-Oriented Molecularly Imprinted Transistor Sensor.

Environmental science & technology
2026

Recent Advances in Photoinduced Iron Catalysis for Decarboxylative C-Heteroatom Bonds Formation.

Chemical record (New York, N.Y.)
2026

A Targeted Nanozyme for STING Activation Improves BiTEs Therapy Outcomes in Colorectal Cancer.

Small (Weinheim an der Bergstrasse, Germany)
2026

Efficacy and Tolerability of Weekly Bortezomib, Lenalidomide, and Dexamethasone Protocols in Transplant-Ineligible Newly Diagnosed Myeloma: An Australian Real-World, Multicenter Study.

Asia-Pacific journal of clinical oncology
2026

Adaptive Pore Deformation in Metal-Organic Framework Nanosheets for Enhanced Enzymatic Catalysis.

Journal of the American Chemical Society
2026

Autologous stem cell transplant for severe, progressive juvenile systemic sclerosis.

Stem cells translational medicine
2026

Nanocarriers for potential treatment of sensorineural hearing loss and retinitis in congenital cytomegalovirus.

Nanomedicine (London, England)
2026

Combating Misinformation in the Digital Age: A Machine Learning Approach to Protect Community Water Fluoridation and Promote Oral Health Equity.

Journal of public health dentistry
2026

Paternal lineage effects of prenatal ethanol exposure: Offspring neuroanatomy and behavior in a multigenerational mouse model of FASD.

Alcohol, clinical & experimental research
2026

From bench to bedside: advances in cell therapy for tuberculosis treatment.

Stem cell research & therapy
2026

Preclinical efficacy and safety evaluation of human embryonic stem cell-derived functional hepatocytes for a clinical trial in acute liver failure.

Stem cell research & therapy
2026

Biomarker-empowered precision navigation of CAR-T cell therapy.

Molecular cancer
2026

Efficacy and safety of peptide radionuclide therapy with 177Lu-DOTATATE in Japanese patients with advanced neuroendocrine neoplasm: a multicenter retrospective study (JON2203-N).

Journal of gastroenterology
2026

Numerical modeling of CZTS based heterostructured solar cell for high efficiency PV performance.

Scientific reports
2026

RF-SIRF reveals a replication stress-specific epigenetic code by spatio-temporal mapping of reversed forks.

Nature communications
2026

Isolated and Combined Exposure to Polystyrene Nanoplastics and a Phthalate Metabolite Mixture Disrupt Antral Follicle Growth and Function of Mice In Vitro.

Toxicological sciences : an official journal of the Society of Toxicology
2026

Recent advances in hierarchically porous metal-organic frameworks mediated enzyme immobilization: progress and perspective.

Critical reviews in biotechnology
2026

Allogeneic hematopoietic stem cell transplantation following T-cell-directed immunotherapy failure in B-cell lymphoma: a real-world case series and systematic literature review.

Leukemia & lymphoma
2026

The Place of Fruits and Herbal Medicines in the Treatment of Diabetes in Pregnancy: Two Sides of the Coin.

The journal of obstetrics and gynaecology research
2026

Survival advantage of reduced-toxicity conditioning in haploidentical hematopoietic cell transplantation for severe aplastic anemia patients with pre-transplant comorbidities.

Transplantation and cellular therapy
2026

Rates and Outcomes of Cardiovascular Complications in Critically Ill Blood or Marrow Transplant Patients: A Retrospective Cohort Study.

Transplantation and cellular therapy
2026

Cancer Therapy and the Kidney.

Kidney international
2026

Adaptive responses of Brassica juncea vs. Sorghum bicolor to increasing toxicity of potentially toxic elements in soil.

Environmental pollution (Barking, Essex : 1987)
2026

Is a Linear Low-density Polyethylene passive sampler suitable for long-term monitoring of Polycyclic Aromatic Hydrocarbons in seawater? A case study of Masan Bay with bioavailability assessment.

Environmental pollution (Barking, Essex : 1987)
2026

Fluorene‑9‑bisphenol‑associated endoplasmic reticulum stress linked to oxidative stress, apoptosis and autophagy in SH‑SY5Y cells.

Toxicology
2026

Thiamethoxam removal by a corn husk biochar/ferric xanthan/okra mucilage hybrid biocomposite: Kinetic and thermodynamic evaluation.

International journal of biological macromolecules
2026

Spray-dried lignocellulosic microparticles as bio-based carriers for nutrient release of monoammonium phosphate.

International journal of biological macromolecules
2026

Study on chitosan/carrageenan core-shell nanoparticles for oral co-administration of insulin/exenatide enhance insulin secretion in type 2 diabetes.

International journal of biological macromolecules
2026

Acetate-based biological platforms: Bridging carbon dioxide utilization and high-value bioproduct production in oleaginous yeasts.

Bioresource technology
2026

Efficient anaerobic metformin biodegradation driven by a Cross-Feeding Consortium: Novel Pathways, Enzymes, and toxicity dynamics.

Bioresource technology

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Striking the right balance with type I interferon signalling in cancer.
    Nature reviews. Cancer· 2026· PMID 41872684mais citado
  2. The TCR in CAR T cell therapy: use it or lose it?
    Cancer gene therapy· 2026· PMID 41872464mais citado
  3. miR-495-3p attenuates cerebral ischemia-reperfusion-induced neuronal inflammation and apoptosis by targeting CCL2 expression.
    In vitro cellular & developmental biology. Animal· 2026· PMID 41872391mais citado
  4. Dual targeting of PI3Kδ and PPARα enhances antitumor activity via FoxO1 activation in follicular lymphoma.
    Cell death & disease· 2026· PMID 41872189mais citado
  5. Continuous evolution of a halogenase enzyme with improved solubility and activity for sustainable bioproduction.
    Nature communications· 2026· PMID 41872188mais citado
  6. Design and Biological Evaluation of Novel Biphenyl-Dihydropyrimidinone Derivatives with Selective Anticancer and Non-Genotoxic Profiles.
    Biochem Cell Biol· 2026· PMID 41871376recente
  7. Discovery of SD-965 as a Potent, Selective, and Efficacious STAT3 PROTAC Degrader.
    J Med Chem· 2026· PMID 41871272recente
  8. Self-Assembled Nanomaterials for ER-Targeted Cancer Therapy: From Molecular Design to Therapeutic Applications.
    Biomacromolecules· 2026· PMID 41871185recente
  9. Repurposing Drugs as Bacteroides fragilis BFT-3 Inhibitors in the Animal Infection Model Galleria mellonella.
    Ann N Y Acad Sci· 2026· PMID 41871160recente
  10. In silico designing of palbociclib loaded PLGA long-acting intramuscular injection for palliative therapy of HR+/HER2- metastatic breast cancer.
    J Pharm Pharmacol· 2026· PMID 41871123recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:251529(Orphanet)
  2. MONDO:0016677(MONDO)
  3. Artigo Wikipedia(Wikipedia)
  4. Q5308960(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

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O35.5 · Assistência prestada à mãe por lesão fetal (suspeitada) causada por drogas
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