Anomalias congênitas causadas por substâncias medicinais ou drogas de abuso administradas ou tomadas pela mãe, ou às quais ela é exposta inadvertidamente durante a fabricação de tais substâncias. O conceito exclui anomalias resultantes da exposição a produtos químicos não medicinais no ambiente.
Introdução
O que você precisa saber de cara
Anomalias congênitas causadas por substâncias medicinais ou drogas de abuso administradas ou tomadas pela mãe, ou às quais ela é exposta inadvertidamente durante a fabricação de tais substâncias. O conceito exclui anomalias resultantes da exposição a produtos químicos não medicinais no ambiente.
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Entender a doença
Do básico ao detalhe, leia no seu ritmo
Preparando trilha educativa...
Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 83 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 232 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Genética e causas
O que está alterado no DNA e como passa nas famílias
Nenhum gene associado encontrado
Os dados genéticos desta condição ainda estão sendo catalogados.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Embriofetopatia tóxica ou relacionada com fármacos
Selecione um estado ou use sua localização para ver resultados.
Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Pesquisa e ensaios clínicos
Nenhum ensaio clínico registrado para esta condição.
Publicações mais relevantes
Striking the right balance with type I interferon signalling in cancer.
Interferons tipo I (IFNs) são importantes na terapia contra o câncer, pois fortalecem a imunidade antitumoral e melhoram a eficácia de outros tratamentos, mas seu uso é limitado por toxicidade e resultados inconsistentes. Este artigo destaca a complexidade da ação dos IFNs, que podem ter efeitos tanto benéficos quanto prejudiciais no tumor, dependendo de diversos fatores. O objetivo da pesquisa é entender profundamente esses mecanismos para reprogramar a atividade dos IFNs, buscando otimizar as terapias oncológicas e torná-las mais eficazes e com menos efeitos adversos para os pacientes.
🇧🇷 traduzidoThe TCR in CAR T cell therapy: use it or lose it?
A terapia com células CAR T, embora vital para alguns cânceres do sangue, ainda enfrenta desafios como persistência limitada, alto custo e toxicidades, especialmente em tumores sólidos. Este artigo explora o papel do receptor de célula T (TCR) natural nas células CAR T: se removê-lo as tornaria mais universais e acessíveis, ou se mantê-lo é crucial para a durabilidade e eficácia da terapia. Otimizar a decisão sobre o TCR é fundamental para desenvolver tratamentos CAR T mais seguros, duradouros e eficazes, beneficiando diretamente pacientes e médicos ao expandir as opções terapêuticas.
🇧🇷 traduzidomiR-495-3p attenuates cerebral ischemia-reperfusion-induced neuronal inflammation and apoptosis by targeting CCL2 expression.
Este estudo investigou a lesão cerebral por isquemia e reperfusão (CI/RI), comum após eventos como AVC, e descobriu que a molécula miR-495-3p está anormalmente baixa nesse contexto, enquanto a CCL2 está elevada. Aumentar os níveis de miR-495-3p demonstrou reduzir significativamente a inflamação e a morte de neurônios, os principais responsáveis pelo dano cerebral, agindo através da regulação de CCL2. Para pacientes e médicos, estes achados são promissores, pois sugerem que a miR-495-3p pode ser um novo alvo terapêutico para desenvolver medicamentos que protejam o cérebro, diminuam a inflamação e a perda neuronal, e potencialmente melhorem o prognóstico e minimizem sequelas em pessoas que sofrem de lesões cerebrais por isquemia e reperfusão.
🇧🇷 traduzidoDual targeting of PI3Kδ and PPARα enhances antitumor activity via FoxO1 activation in follicular lymphoma.
Para superar a resistência frequentemente observada no tratamento do linfoma folicular (FL) com inibidores de PI3Kδ, este estudo apresenta uma estratégia combinada promissora. A junção de um inibidor de PI3Kδ (linperlisib) com um agonista de PPAR (chiglitazar) demonstrou forte atividade antitumoral em modelos de FL, sendo superior às terapias únicas e com boa tolerabilidade. Além disso, a reativação da proteína FoxO1 é crucial para a eficácia, podendo servir como um importante biomarcador para prever a resposta e orientar futuras avaliações clínicas.
🇧🇷 traduzidoContinuous evolution of a halogenase enzyme with improved solubility and activity for sustainable bioproduction.
A halogenação é fundamental para a estabilidade e função de muitos fármacos, mas os métodos químicos tradicionais são problemáticos e tóxicos. Este estudo apresenta a RebHEvo4, uma enzima halogenase evoluída que permite a produção altamente eficiente e site-específica de compostos halogenados. Para pacientes e médicos, isso significa um avanço significativo na biomanufatura sustentável de medicamentos halogenados, incluindo novos peptídeos antimicrobianos, tornando-os potencialmente mais acessíveis, seguros e eficazes.
🇧🇷 traduzidoPublicações recentes
Design and Biological Evaluation of Novel Biphenyl-Dihydropyrimidinone Derivatives with Selective Anticancer and Non-Genotoxic Profiles.
Discovery of SD-965 as a Potent, Selective, and Efficacious STAT3 PROTAC Degrader.
Self-Assembled Nanomaterials for ER-Targeted Cancer Therapy: From Molecular Design to Therapeutic Applications.
Repurposing Drugs as Bacteroides fragilis BFT-3 Inhibitors in the Animal Infection Model Galleria mellonella.
In silico designing of palbociclib loaded PLGA long-acting intramuscular injection for palliative therapy of HR+/HER2- metastatic breast cancer.
📚 EuropePMCmostrando 199
An update on the pharmacokinetic and pharmacodynamic interactions between antidepressants and antiseizure medications.
Expert opinion on drug metabolism & toxicologyEngineering a Tyrosol-Responsive Dynamic System in Saccharomyces cerevisiae for Adaptive Regulation of Hydroxytyrosol Biosynthesis.
Journal of agricultural and food chemistryPhytochemical-based nanomedicine as a promising therapeutic strategy for erectile dysfunction.
Asian journal of andrologyDHX9 inhibition enhances paclitaxel sensitivity by inducing mitotic failure in ovarian and endometrial cancers.
Molecular cancer therapeuticsHarnessing the gut microbiota in extra-intestinal cancers: from causal evidence to immunotherapy strategies.
ImmunotherapyPhotocaged Chloroquine Derivatives for the Light-Dependent Inhibition of Autophagy in Cancer Stem Cells.
ACS chemical biologyExtracellular Vesicles in Drug Delivery: From Quality Assurance to Therapeutic Application.
International journal of nanomedicineIntranasal Nano-Delivery Systems: Emerging Strategies for Central Nervous System Disease Therapeutics.
International journal of nanomedicineSuccessful Treatment of Acanthamoeba Keratitis Using 0.08% Polyhexamethylene Biguanide Monotherapy: A Report of a Case in Latin America.
CureusInfertility and Hematologic Malignancies in Low-Resource Settings: Challenges and Perspectives.
CureusGeraniol Mitigates Cytarabine-Induced Hepatotoxicity in Mice via PI3K/AKT-Mediated NRF2 Activation.
Journal of biochemical and molecular toxicologyDiscovery of ferulic acid carbamate derivatives as dual-targeting agents of BuChE and Nrf2 for Alzheimer's disease.
Journal of enzyme inhibition and medicinal chemistry[Characteristics and antimicrobial activities of selenium nanoparticles biosynthesized by selenium-tolerant yeast].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology[Optimization of microbial production process of γ-polyglutamic acid and research progress in its application in agriculture].
Sheng wu gong cheng xue bao = Chinese journal of biotechnologyNanoscaffold-based 3D human liver spheroids for predictive hepatotoxicity screening of antimalarial compounds from the global health priority box.
Parasites & vectorsDiabetes mellitus in ECOWAS: an overview of the safety and efficacy of medicinal plants used in traditional medicine practices.
Tropical medicine and healthReal-world data on toxic anterior segment syndrome.
Journal of cataract and refractive surgeryIn Vitro and In Silico DNA Binding Studies of Novel 1,2,3-Triazole-Based Coumarin Compounds.
Chemistry & biodiversityStriking the right balance with type I interferon signalling in cancer.
Nature reviews. CancerEfficacy of Aminocaproic Acid in Preventing Postoperative Hematoma in Breast Cancer Surgery: A Prospective Study.
Journal of surgical oncologyMechanistic Insights into pH-Responsive Drug Release and Antitumor Effects of an Albumin-Pirarubicin Conjugate.
Pharmaceutical researchEmployment status and food insecurity in cancer survivorship: evidence from the medical expenditure panel survey.
Cancer causes & control : CCCAluminium, copper, nickel, lead and zinc in e-liquids from contemporary disposable vapes.
Environmental monitoring and assessmentSource-sink relationships and health risk assessment of heavy metals in farmland soils of a Southwest Karst Industrial cluster: based on PMF and Monte Carlo simulation.
Environmental geochemistry and healthThe TCR in CAR T cell therapy: use it or lose it?
Cancer gene therapymiR-495-3p attenuates cerebral ischemia-reperfusion-induced neuronal inflammation and apoptosis by targeting CCL2 expression.
In vitro cellular & developmental biology. AnimalDual targeting of PI3Kδ and PPARα enhances antitumor activity via FoxO1 activation in follicular lymphoma.
Cell death & diseaseContinuous evolution of a halogenase enzyme with improved solubility and activity for sustainable bioproduction.
Nature communicationsK16F/E22F Mutation Promotes Oligomerization and Alters β-Sheet Topology of Aβ16-22 Peptides: Insights from Molecular Dynamics Simulations.
ACS chemical neuroscienceTrophic magnification and distribution of per-/polyfluoroalkyl substances (PFAS) in an AFFF-impacted aquatic food web.
Environmental toxicology and chemistryA method for embryo-larval development toxicity testing on an endemic and commercially important mussel, Perna canaliculus.
Environmental toxicology and chemistryArbuscular Mycorrhizal Consortium Alleviates Chromium(VI) Stress and Enhances Seed Phytochemicals in Psoralea corylifolia L.
Plant science : an international journal of experimental plant biologyInhibition of voltage-dependent anion channel 1 aggregation protects pancreatic beta-cell mitochondria from glucose toxicity.
International journal of biological macromoleculesOccurrence and Transplacental Transfer of Benzotriazole Ultraviolet Stabilizers in Maternal-Cord Serum and Association with Birth Outcomes.
Environmental pollution (Barking, Essex : 1987)Design of Molecularly Imprinted Nickel Ferrite Photocatalyst and Its Application in Peroxodisulfate-Triggered Phenol Degradation.
Environmental researchMyeloperoxidase in the pathogenesis of sickle cell disease.
Archives of biochemistry and biophysicsSeafood-Based Dietary Cadmium Exposure Triggers Physiological Stress and Gene Dysregulation in Zebrafish.
Environmental toxicology and pharmacologyNuclear and cytoskeletal structural alterations in human alveolar epithelial cells by solvent-extracted organic matter from PM2.5.
Environmental toxicology and pharmacologyMetabolic pathway modulation and oxidative imbalance triggered by decamethylcyclopentasiloxane (D5) in zebrafish embryo.
Environmental toxicology and pharmacologyAcute Oral Toxicity and Hepatic Responses to Paederia foetida Leaf Extract in Wistar Rats.
Journal of ethnopharmacologyDiagnostics for priority bacterial pathogens: global gaps and research needs for curbing antimicrobial resistance in low-resource settings.
The Lancet. MicrobeGambogenic acid suppresses T cell proliferation via inhibition of ERK signaling pathway.
International immunopharmacologyTracking metal-containing particles in wastewater using single-particle ICP-MS.
TalantaPrognostic value of early Epstein-Barr Virus DNA response in patients with locoregionally advanced nasopharyngeal carcinoma.
Oral oncologyCardiac Safety Profiles of First-Generation vs. Second-Generation BTK Inhibitors: A Meta-Analysis.
The oncologistDesign and Biological Evaluation of Novel Biphenyl-Dihydropyrimidinone Derivatives with Selective Anticancer and Non-Genotoxic Profiles.
Biochemistry and cell biology = Biochimie et biologie cellulaireDiscovery of SD-965 as a Potent, Selective, and Efficacious STAT3 PROTAC Degrader.
Journal of medicinal chemistrySelf-Assembled Nanomaterials for ER-Targeted Cancer Therapy: From Molecular Design to Therapeutic Applications.
BiomacromoleculesRepurposing Drugs as Bacteroides fragilis BFT-3 Inhibitors in the Animal Infection Model Galleria mellonella.
Annals of the New York Academy of SciencesIn silico designing of palbociclib loaded PLGA long-acting intramuscular injection for palliative therapy of HR+/HER2- metastatic breast cancer.
The Journal of pharmacy and pharmacologyFrom plant pair to gastroprotection: chemical standardization and in vivo validation of Akebiae Fructus-Hoveniae semen against ethanol-mediated mucosal damage.
The Journal of pharmacy and pharmacologyIdentification of polyphenols as novel neuropilin-1 cendR pocket inhibitors to block SARS-CoV-2 entry and enhance variant resistance.
PloS oneElucidating the potential carcinogenic molecular mechanisms of parabens in head and neck squamous cell carcinoma through network toxicology and molecular docking.
PloS oneThe Regimen of Cladribine, Cytarabine, and Venetoclax (CAV) Induces Apoptosis in Acute Myeloid Leukemia Cells by Enhancing DNA Damage.
Journal of visualized experiments : JoVEGabapentinoids and unexplained death in general practice: Case series and feasibility study arising from a critical incident.
The European journal of general practiceEngineered Protein Nanoparticles Enable Targeted Topical Delivery of Upadacitinib for Enhanced Arthritis Therapy.
ACS applied bio materialsNanozyme-Mediated PROTACs Delivery for Targeted Protein Degradation and Ferroptosis Sensitization in Prostate Cancer.
Angewandte Chemie (International ed. in English)Assessment of chemotherapy dosing and regimen optimization in geriatric oncology patients diagnosed with solid organ malignancies.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy PractitionersL. carnitine modulates oxidative stress, steroidogenic gene disturbance, and testicular histopathology induced by Bisphenol A in male rats.
Veterinary research communicationsStudy of a lipid extract from Eryx snakes in rat adjuvant-induced arthritis under a therapeutic regimen: comparison with methotrexate and leflunomide.
InflammopharmacologyPersistent Financial Burden Among U.S. Cancer Survivors Despite Affordable Care Act Implementation: Implications for Survivorship Financial Education.
Journal of cancer education : the official journal of the American Association for Cancer EducationDiscovery of potent thymidine phosphorylase inhibitors from Euphorbia pulcherrima Willd. ex Klotzsch with experimental validation and computational analysis.
Journal of computer-aided molecular designTime and contamination level dependence of metal bioaccumulation and multibiomarker responses in fish: implications for biomonitoring.
Environmental monitoring and assessmentIn silico ADMET profiling and DNA interaction study of xanthoxylin: assessment of pBR322 DNA protection against oxidative damage.
Journal of biological physicsSenescence as a Central Node in Alzheimer's Disease: Molecular Triggers, Cellular Effectors, and RNA-Based Interventions.
Neurochemical researchQuantitative analysis and method validation of mirogabalin in postmortem blood and urine using liquid chromatography-tandem mass spectrometry.
Forensic toxicologyAssessment of risks to the environment and human health associated with potentially toxic elements in the surface water and sediments in the mining-affected area.
Environmental geochemistry and healthAccumulation of Potentially Toxic Elements and Bioindicator Potential of Necrophagous Flies in Exposed Municipal Wastes.
Archives of environmental contamination and toxicology2g/m2 Ara-c induced more favorable outcome than 1g/m2 Ara-c in CLAG treatment for refractory or relapsed acute myeloid leukemia without increase toxicity: a multicenter propensity score matching analysis.
Annals of hematologyThe respiratory health effects of heated tobacco product aerosols in a primary human airway epithelial cell model.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and TobaccoMajor Missing Source of Alkylated Polycyclic Aromatic Hydrocarbon Emissions from Oil Spill Volatilization.
Environmental science & technologySafety, Distribution, and Pharmacokinetics of Biodegradable P(AAm-co-MAA) Nanogels Following Systemic Administration in Mice.
Journal of biomedical materials research. Part AAssociation of Prophylactic Intravenous Corticosteroid Premedication With Toxicity and Survival in Patients Receiving Enfortumab Vedotin for Locally Advanced or Metastatic Urothelial Carcinoma.
International journal of urology : official journal of the Japanese Urological AssociationAssociation between short-term radiation-induced toxicity and oncological outcomes in high-risk prostate cancer: a retrospective single-centre cohort study.
Acta oncologica (Stockholm, Sweden)Safety and efficacy of echinocandin antifungal agents in Candida albicans endophthalmitis.
Antimicrobial agents and chemotherapyTunable low-rate genomic recombination with Cre-lox in Escherichia coli: a versatile tool for anoxic environmental biosensing and synthetic biology.
Applied and environmental microbiologyOutstanding presence of New Delhi metallo-beta-lactamase in carbapenem-resistant Enterobacterales and exceptionally potent in vitro activity of cefiderocol and aztreonam-avibactam emphasises their immediate access in India.
Transactions of the Royal Society of Tropical Medicine and HygieneSHED-derived exosomes ameliorate age-related osteoporosis by activating mitophagy in senescent bone marrow mesenchymal stem cells.
Nanomedicine (London, England)An Engineered Triple-Functional Nanoplatform for Effective Sepsis Therapy via Macrophage-Targeted Polo-like Kinase 1 Inhibition.
ACS nanoFabrication and sensing performance of a highly sensitive room-temperature NO₂ gas sensor based on few-layer Ti₃C₂ MXene/WO₃ nanoparticle composites.
NanotechnologyFirst Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)ToxPLTC: Peptide Toxicity Prediction by Integrating Pretrained T5 Protein Language Model and Text Convolutional Neural Network.
Journal of chemical information and modelingBiomimetic Nanoplatform for Targeted Glioblastoma Therapy via Concurrently Triggering GPX4/DHODH Mediated Ferroptosis.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)Characterization and hemocompatibility of poly (N-acryloyl-L-tryptophan) nanoparticles as targeting delivery carriers for vinblastine.
Journal of biomaterials applicationsRetention and mobility of phosphogypsum constituents in carbonate aquifer rock materials.
Environmental science. Processes & impactsApplication and mechanistic research of novel therapeutic strategies in cisplatin-resistant small cell lung cancer.
Annals of medicineCase Report: Adjuvant radiation therapy for cardiac intimal sarcoma with long-term disease control.
Frontiers in oncologyExposure to per- and poly-fluoroalkyl substances and associations with embryo quality and adverse pregnancy outcomes: a prospective cohort study.
Frontiers in public healthResearch Progress on Copper Metabolism, Cuprotosis, and Their Regulatory Mechanism in Tumor Diagnosis and Treatment.
Cancer management and researchSmart polymeric nanoparticles for targeted delivery and microenvironment-responsive therapy in pancreatic cancer.
Smart materials in medicineVerbenone-based selenophene derivatives as potential anti-cancer agents: synthesis and biological evaluation in 2D and 3D A549 cell models.
RSC medicinal chemistryHybrid Hydrogels in Pain Management Application: A Comprehensive Review.
Clinical pharmacology : advances and applicationsCadmium Exposure May Induce Potential Brain Tumour Initiation by Regulating SHH, GLI1, BMI1 and P53 in the SHH-GLI1 Cell Signalling Pathway.
Annals of neurosciencesA Comprehensive Review of Nanotechnological Innovations in Cancer: from Molecular Pathways to Clinical Applications.
Journal of CancerIncomplete Ascher's Syndrome Misdiagnosed as Eczema: A Case Report.
Clinical, cosmetic and investigational dermatologyLipid-Engineered Small-Sized Metal-Organic Frameworks for Targeted Delivery of Anlotinib in Lung Cancer Treatment.
International journal of nanomedicineHow Effective are Nanotechnology-Based Therapeutics to Treat Autoimmune Diseases.
International journal of nanomedicineLiposome-Based Drug Delivery for Diabetes: Therapeutic Applications and a Nanomedicine Perspective on Diabetic Complications.
International journal of nanomedicineThermoradiotherapy-Driven Enhancement of Cuproptosis by Copper-Nitroimidazole Based Nanoparticles.
International journal of nanomedicineFilamentous Phage for Therapeutic Applications in Non-Small Cell Lung Cancer and Brain Metastases: Recent Prospect.
International journal of nanomedicineElectron Irradiation Effects on N and Fe3+ Doped Carbon Dots and the Application in Radiotherapy of Lung Cancer.
International journal of nanomedicinepH-Sensitive Long-Circulating Nanoliposomes with CU1 for Effective Against Lung Cancer.
International journal of nanomedicineA Self-Assembling Nanomodulator for Synergistic Therapy of Intracerebral Hemorrhage.
International journal of nanomedicineNanotechnology-Driven Cancer Therapies for Precision Oncology: Advances and Clinical Outlook.
International journal of nanomedicineDistinct immunologic patterns of response and resistance to anti-PD-1/PD-L1-based immunotherapy in patients with soft tissue sarcoma.
Frontiers in immunologyTargeting the oxidative stress-neuroinflammation axis: the mechanism of arctigenin's broad-spectrum analgesia with limited side effects.
Frontiers in immunologyThe impact of chronic comorbidities on cancer immunoediting: challenges and opportunities for immunotherapies.
Frontiers in immunologyReal-world safety profile of T-cell engagers: evidence from multi-database analysis with CAR-T comparisons.
Frontiers in immunologyEfficacy and safety of adding immune checkpoint inhibitors to standard chemotherapy or chemoradiotherapy for advanced or recurrent cervical cancer: a meta-analysis.
Frontiers in immunologyInhibition of DDX5-Mediated G-Quadruplex Unwinding in the β-Catenin 5'-UTR by Magnesium Isoglycyrrhizinate Alleviates Chemotherapy-Induced Intestinal Injury.
Research (Washington, D.C.)Long-Term Control of Giant Retroperitoneal Liposarcoma by Proton Beam Therapy Combined With Hyperthermia: A Case Report and Literature Review.
CureusSynchronous Extensive-Stage Small Cell Lung Cancer and Multiple Myeloma Detected by Marked Hypergammaglobulinemia.
CureusChemotherapy and the Skin: Understanding Dermatologic Side Effects.
CureusCorticosteroid Taper Duration and Relapse Rate in Immune Checkpoint Inhibitor-Induced Pneumonitis: A Meta-Analysis.
CureusDoxycycline-Induced Phototoxicity Localized to Vitiligo-Affected and Sun-Exposed Skin.
CureusAcute Boric Acid Poisoning With Chronic Renal Failure Successfully Treated With Continuous Hemofiltration.
CureusFeasibility study on the impact of mechanical recycling on the extractables profile and toxicologic safety assessment of small-scale polycarbonate bioreactors.
International journal of pharmaceutics: XFunctional roles and mechanisms of NAT10-mediated RNA ac4C modification in normal development and cancer progression.
Frontiers in cell and developmental biologyLineage-Specific Disruption of Hematopoiesis by Oxaliplatin: Mechanisms of Erythropoietin Resistance and Immune Suppression.
Journal of hematology and oncology researchElectro-acupuncture attenuates cyclophosphamide-induced premature ovarian insufficiency in rats through miRNA regulation and TGFβ/Smad pathway modulation.
American journal of translational researchPhytochemical small molecules from Stauntonia chinensis DC as multi-target modulators: molecular mechanisms and therapeutic potential.
American journal of translational researchIsolated immune-mediated enteritis in patients treated with immune checkpoint inhibitor therapy.
Annals of gastroenterologyMulticenter dose de-escalation phase I trial of pressurized intraperitoneal aerosolized chemotherapy (PIPAC) nab-paclitaxel and cisplatin in combination with systemic nab-paclitaxel in recurrent ovarian cancer patients: trial in progress.
Pleura and peritoneumEndocrine Therapy versus Chemotherapy After CDK4/6 Inhibitor Progression in HR+/HER2- Metastatic Breast Cancer: A Multicenter Real-World Study from Turkey.
Breast cancer (Dove Medical Press)Phellinus linteus polysaccharides inhibit castration-resistant prostate cancer progression possibly via dual modulation of PIK3R1 and PGC-1α: a preclinical evaluation.
American journal of cancer researchBiochar and nano-silicon partnership alleviates vanadium toxicity in rice through improving antioxidant defense, nitrogen assimilation and iron plaque formation.
Frontiers in plant scienceCerium oxide nanoparticles enhance rice productivity by modulating nitric oxide signaling, carbon metabolism, and potassium homeostasis under chromium-induced environmental stress.
Frontiers in plant scienceNew progress in the production, oxidative damage, and scavenging mechanisms of reactive oxygen species in plants under abiotic stress.
Frontiers in plant scienceChemotherapy-Induced Toxicities in Pediatric Cancer Patients: A Cross-Sectional Survey Using a Child- and Caregiver-Reported Outcome Tool in Tanzania.
Drug, healthcare and patient safetyThe Hidden Perils of Allopurinol: A Systematic Review of Allopurinol-Induced DRESS (Drug Reaction With Eosinophilia and Systemic Symptoms) Syndrome.
CureusPreliminary insights into intratesticular and intraepididymal administration of eugenol: histological alterations and impact on sperm motility in Wistar rats.
Animal reproductionDual-Biosensor for Five Drugs Detection in Precision Oncology.
BioNanoScienceMassart iron oxide nanoparticles in mechanobiology.
Nanoscale advancesBSA-modified g-C3N4 nanosheets as a sustainable dual-purpose adsorbent for efficient Pb2+ removal and CO2 capture.
Nanoscale advancesTransformation of 3-(4-methoxybenzylidine)-5-(p-tolyl)-2(3H)-furanone into new nitrogen heterocyclic candidates as insecticidal agents with in silico studies.
RSC advancesAdsorptive and photocatalytic strategies for carmoisine removal: mechanisms, material innovations, and environmental implications.
RSC advancesGreen biosynthesis of selenium nanoparticles by Ralstonia insidiosa which demonstrate effectiveness against human cancer cells, Candida species and multidrug-resistant Acinetobacter baumannii.
RSC advancesTwo cases (a decade apart) of severe sulfonylurea-positive hypoglycemia associated with inhaled heroin use.
JCEM case reportsImmunoinformatic insights for design and clinical prospects of pan-RAS cancer vaccine.
Frontiers in medicineImmunoinformatics-driven multi-epitope vaccine design targeting PSMA, STEAP1, and B7H3 for prostate cancer.
Frontiers in medicineDevelopment of Membrane-Targeting Cannabigerol Derivatives as Potent Broad-Spectrum Antibacterial Agents.
Drug design, development and therapyProfiles of neuropsychiatric toxicity associated with different endocrine therapies for breast cancer: a global pharmacovigilance study based on FAERS and VigiAccess.
Frontiers in pharmacologySex-related pharmacokinetic and pharmacological responses to 4F-furanylfentanyl.
Frontiers in pharmacologyPyrimidine nucleoside: inspiration for novel antimicrobial agent.
Frontiers in pharmacologyArtificial intelligence modeling and investigation of metal organic frameworks in drug delivery: modeling of loading capacity and toxicity behavior.
Frontiers in chemistryToxiVerse: A Public Platform for Chemical Toxicity Data Sharing and Customizable Predictive Modeling.
bioRxiv : the preprint server for biologyMarine Algae as Sustainable Platforms for the Green Synthesis of Metal Nanoparticles.
ACS omegaFunctional Effects of Cyclization on Li1 Peptide Activity against Metacyclic Leishmania amazonensis Internalization.
ACS omegaPaper-Based Microfluidics Platform for Enhanced On-Site Electrochemical Detection of Manganese in Water.
ACS omegaThermocatalytic Transformation of Nitriles Utilizing Pristine and Calcined ZnCr Layered Double Hydroxides for the Synthesis of Various Tetrazole- and Kynurenic Acid-Based Drug Candidates.
ACS omegaSafety, Sedative, and Anxiolytic Evaluation of MECS Hard Capsules Using In Silico and In Vivo Approaches.
ACS omegaImpact of age on outcomes after CD19 CAR T-cell therapy for large B-cell lymphomas.
Blood neoplasiaArtificial Intelligence for Predicting Immunotherapy Efficacy in Non-Small Cell Lung Cancer.
Journal of inflammation researchCase Report: Maculopathy following standard dose intracameral cefuroxime injection during ICL surgery.
Frontiers in ophthalmologyRevolutionizing Food Safety: A Systematic Review of Nanotechnology-Based Aflatoxin Detection (2010-2023).
Nanotechnology, science and applicationsSublethal Effects of the Insect Growth Regulator Novaluron on the Midgut Integrity and Survival of Adult Honey Bee Apis mellifera Workers.
ACS environmental AuMethodological Challenges in the Application of QSAR Models for Chemical Prioritization and Toxicity Assessment: A Case Study on Aryl Hydrocarbon Receptor Activity in Environmental Pollutant Mixtures.
ACS environmental AuLaboratory-Scale Reuse of Glass/ITO Substrates for Single Junction Perovskite Solar Cells.
ACS sustainable chemistry & engineeringWhen Survival Improves But Quality of Life Does Not: A Model-Based Meta-Analysis of Immune Checkpoint Inhibitors.
medRxiv : the preprint server for health sciencesAn agentic AI system enhances clinical detection of immunotherapy toxicities: a multi-phase validation study.
medRxiv : the preprint server for health sciencesAdvancing pesticide risk assessment: the role of adverse outcome pathways and new approach methodologies - what's next?
Annali dell'Istituto superiore di sanitaBiomonitoring and toxicological assessment of Ochratoxin A and Citrinin in a sex-gender perspective: The OTABioTox Project.
Annali dell'Istituto superiore di sanitaAssessing Source Contributions to Air Quality and Noise in Unconventional Oil Shale Plays.
Research report (Health Effects Institute)Real-time monitoring of microplastic accumulation in fish bodies using transparent goldfish revealed initial attack on the gill.
Toxicology mechanisms and methodsOvercoming barriers, driving progress: Clinical science at IAS 2025.
Journal of the International AIDS SocietyThe Real-World Safety Profile of Temazepam: A 20-Year Pharmacovigilance Analysis Based on the Large-Scale FAERS Database.
CNS neuroscience & therapeuticsDesign and fabrication of plasmonic hedgehog-shaped covalent organic framework nanocomposites for indirect SERS-based ultradetection of water contaminant terbutryn.
NanoscaleROS-activated oral enterosorbent nanogel to block gastrointestinal absorption of lead and cadmium: an in vitro study.
Toxicology mechanisms and methodsAging MPs in aquatic ecosystems: a review on occurrence, interactions, vector effects, and ecotoxicology.
Drug and chemical toxicologyFemtomolar Congener-Selective Detection of Perfluoroalkyl Substances in Water by a Cyclodextrin-Oriented Molecularly Imprinted Transistor Sensor.
Environmental science & technologyRecent Advances in Photoinduced Iron Catalysis for Decarboxylative C-Heteroatom Bonds Formation.
Chemical record (New York, N.Y.)A Targeted Nanozyme for STING Activation Improves BiTEs Therapy Outcomes in Colorectal Cancer.
Small (Weinheim an der Bergstrasse, Germany)Efficacy and Tolerability of Weekly Bortezomib, Lenalidomide, and Dexamethasone Protocols in Transplant-Ineligible Newly Diagnosed Myeloma: An Australian Real-World, Multicenter Study.
Asia-Pacific journal of clinical oncologyAdaptive Pore Deformation in Metal-Organic Framework Nanosheets for Enhanced Enzymatic Catalysis.
Journal of the American Chemical SocietyAutologous stem cell transplant for severe, progressive juvenile systemic sclerosis.
Stem cells translational medicineNanocarriers for potential treatment of sensorineural hearing loss and retinitis in congenital cytomegalovirus.
Nanomedicine (London, England)Combating Misinformation in the Digital Age: A Machine Learning Approach to Protect Community Water Fluoridation and Promote Oral Health Equity.
Journal of public health dentistryPaternal lineage effects of prenatal ethanol exposure: Offspring neuroanatomy and behavior in a multigenerational mouse model of FASD.
Alcohol, clinical & experimental researchFrom bench to bedside: advances in cell therapy for tuberculosis treatment.
Stem cell research & therapyPreclinical efficacy and safety evaluation of human embryonic stem cell-derived functional hepatocytes for a clinical trial in acute liver failure.
Stem cell research & therapyBiomarker-empowered precision navigation of CAR-T cell therapy.
Molecular cancerEfficacy and safety of peptide radionuclide therapy with 177Lu-DOTATATE in Japanese patients with advanced neuroendocrine neoplasm: a multicenter retrospective study (JON2203-N).
Journal of gastroenterologyNumerical modeling of CZTS based heterostructured solar cell for high efficiency PV performance.
Scientific reportsRF-SIRF reveals a replication stress-specific epigenetic code by spatio-temporal mapping of reversed forks.
Nature communicationsIsolated and Combined Exposure to Polystyrene Nanoplastics and a Phthalate Metabolite Mixture Disrupt Antral Follicle Growth and Function of Mice In Vitro.
Toxicological sciences : an official journal of the Society of ToxicologyRecent advances in hierarchically porous metal-organic frameworks mediated enzyme immobilization: progress and perspective.
Critical reviews in biotechnologyAllogeneic hematopoietic stem cell transplantation following T-cell-directed immunotherapy failure in B-cell lymphoma: a real-world case series and systematic literature review.
Leukemia & lymphomaThe Place of Fruits and Herbal Medicines in the Treatment of Diabetes in Pregnancy: Two Sides of the Coin.
The journal of obstetrics and gynaecology researchSurvival advantage of reduced-toxicity conditioning in haploidentical hematopoietic cell transplantation for severe aplastic anemia patients with pre-transplant comorbidities.
Transplantation and cellular therapyRates and Outcomes of Cardiovascular Complications in Critically Ill Blood or Marrow Transplant Patients: A Retrospective Cohort Study.
Transplantation and cellular therapyCancer Therapy and the Kidney.
Kidney internationalAdaptive responses of Brassica juncea vs. Sorghum bicolor to increasing toxicity of potentially toxic elements in soil.
Environmental pollution (Barking, Essex : 1987)Is a Linear Low-density Polyethylene passive sampler suitable for long-term monitoring of Polycyclic Aromatic Hydrocarbons in seawater? A case study of Masan Bay with bioavailability assessment.
Environmental pollution (Barking, Essex : 1987)Fluorene‑9‑bisphenol‑associated endoplasmic reticulum stress linked to oxidative stress, apoptosis and autophagy in SH‑SY5Y cells.
ToxicologyThiamethoxam removal by a corn husk biochar/ferric xanthan/okra mucilage hybrid biocomposite: Kinetic and thermodynamic evaluation.
International journal of biological macromoleculesSpray-dried lignocellulosic microparticles as bio-based carriers for nutrient release of monoammonium phosphate.
International journal of biological macromoleculesStudy on chitosan/carrageenan core-shell nanoparticles for oral co-administration of insulin/exenatide enhance insulin secretion in type 2 diabetes.
International journal of biological macromoleculesAcetate-based biological platforms: Bridging carbon dioxide utilization and high-value bioproduct production in oleaginous yeasts.
Bioresource technologyEfficient anaerobic metformin biodegradation driven by a Cross-Feeding Consortium: Novel Pathways, Enzymes, and toxicity dynamics.
Bioresource technologyAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
Ainda não temos associações cadastradas para Embriofetopatia tóxica ou relacionada com fármacos.
É de uma associação que acompanha esta doença? Fale com a gente →
Comunidades
Grupos ativos de quem convive com esta doença aqui no Raras
Ainda não existe comunidade no Raras para Embriofetopatia tóxica ou relacionada com fármacos
Pacientes, familiares e cuidadores se organizam em comunidades pra compartilhar experiências, fazer perguntas e se apoiar. Você pode ser o primeiro.
Tire suas dúvidas
Perguntas, dicas e experiências compartilhadas aqui na página
Participe da discussão
Faça login para postar dúvidas, compartilhar experiências e interagir com especialistas.
Fazer loginDoenças relacionadas
Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico
Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Striking the right balance with type I interferon signalling in cancer.
- The TCR in CAR T cell therapy: use it or lose it?
- miR-495-3p attenuates cerebral ischemia-reperfusion-induced neuronal inflammation and apoptosis by targeting CCL2 expression.
- Dual targeting of PI3Kδ and PPARα enhances antitumor activity via FoxO1 activation in follicular lymphoma.
- Continuous evolution of a halogenase enzyme with improved solubility and activity for sustainable bioproduction.
- Design and Biological Evaluation of Novel Biphenyl-Dihydropyrimidinone Derivatives with Selective Anticancer and Non-Genotoxic Profiles.
- Discovery of SD-965 as a Potent, Selective, and Efficacious STAT3 PROTAC Degrader.
- Self-Assembled Nanomaterials for ER-Targeted Cancer Therapy: From Molecular Design to Therapeutic Applications.
- Repurposing Drugs as Bacteroides fragilis BFT-3 Inhibitors in the Animal Infection Model Galleria mellonella.
- In silico designing of palbociclib loaded PLGA long-acting intramuscular injection for palliative therapy of HR+/HER2- metastatic breast cancer.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:251529(Orphanet)
- MONDO:0016677(MONDO)
- Artigo Wikipedia(Wikipedia)
- Q5308960(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar